A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
Porphyrins with four methyl and four propionic acid side chains attached to the pyrrole rings. Elevated levels of Coproporphyrin III in the urine and feces are major findings in patients with HEREDITARY COPROPORPHYRIA.
Porphyrins which are combined with a metal ion. The metal is bound equally to all four nitrogen atoms of the pyrrole rings. They possess characteristic absorption spectra which can be utilized for identification or quantitative estimation of porphyrins and porphyrin-bound compounds.
Iron-free derivatives of heme with 4 methyl groups, 2 hydroxyethyl groups and 2 propionic acid groups attached to the pyrrole rings. Some of these PHOTOSENSITIZING AGENTS are used in the PHOTOTHERAPY of malignant NEOPLASMS.
A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
Porphyrins with four acetic acid and four propionic acid side chains attached to the pyrrole rings.
Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.
Porphyrins with four methyl and two propionic acid side chains attached to the pyrrole rings.
A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
Porphyrins with four methyl, two ethyl, and two propionic acid side chains attached to the pyrrole rings.
A sebaceous gland that, in some animals, acts as an accessory to the lacrimal gland. The harderian gland excretes fluid that facilitates movement of the third eyelid.
The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.
A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
A complex mixture of monomeric and aggregated porphyrins used in the photodynamic therapy of tumors (HEMATOPORPHYRIN PHOTORADIATION). A purified component of this mixture is known as DIHEMATOPORPHYRIN ETHER.
Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.
Therapy using oral or topical photosensitizing agents with subsequent exposure to light.
Keto acids that are derivatives of 4-oxopentanoic acids (levulinic acid).
The purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of PHOTODYNAMIC THERAPY in the United States.
Colorless reduced precursors of porphyrins in which the pyrrole rings are linked by methylene (-CH2-) bridges.
An enzyme that catalyzes the decarboxylation of UROPORPHYRINOGEN III to coproporphyrinogen III by the conversion of four acetate groups to four methyl groups. It is the fifth enzyme in the 8-enzyme biosynthetic pathway of HEME. Several forms of cutaneous PORPHYRIAS are results of this enzyme deficiency as in PORPHYRIA CUTANEA TARDA; and HEPATOERYTHROPOIETIC PORPHYRIA.
An enzyme that catalyzes the tetrapolymerization of the monopyrrole PORPHOBILINOGEN into the hydroxymethylbilane preuroporphyrinogen (UROPORPHYRINOGENS) in several discrete steps. It is the third enzyme in the 8-enzyme biosynthetic pathway of HEME. In humans, deficiency in this enzyme encoded by HMBS (or PBGD) gene results in a form of neurological porphyria (PORPHYRIA, ACUTE INTERMITTENT). This enzyme was formerly listed as EC 4.3.1.8
Chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N(21),N(22),N(23),N(24)) ferrate(2-) dihydrogen.
An agricultural fungicide and seed treatment agent.
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
Proteins that contain an iron-porphyrin, or heme, prosthetic group resembling that of hemoglobin. (From Lehninger, Principles of Biochemistry, 1982, p480)
Measurement of the intensity and quality of fluorescence.
The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.
An autosomal dominant or acquired porphyria due to a deficiency of UROPORPHYRINOGEN DECARBOXYLASE in the LIVER. It is characterized by photosensitivity and cutaneous lesions with little or no neurologic symptoms. Type I is the acquired form and is strongly associated with liver diseases and hepatic toxicities caused by alcohol or estrogenic steroids. Type II is the familial form.
Porphyrinogens which are intermediates in heme biosynthesis. They have four acetic acid and four propionic acid side chains attached to the pyrrole rings. Uroporphyrinogen I and III are formed from polypyrryl methane in the presence of uroporphyrinogen III cosynthetase and uroporphyrin I synthetase, respectively. They can yield uroporphyrins by autooxidation or coproporphyrinogens by decarboxylation.
A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.
A membrane-bound flavoenzyme that catalyzes the oxygen-dependent aromatization of protoporphyrinogen IX (Protogen) to protoporphyrin IX (Proto IX). It is the last enzyme of the common branch of the HEME and CHLOROPHYLL pathways in plants, and is the molecular target of diphenyl ether-type herbicides. VARIEGATE PORPHYRIA is an autosomal dominant disorder associated with deficiency of protoporphyrinogen oxidase.
1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid diethyl ester.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
An enzyme that catalyzes the formation of porphobilinogen from two molecules of 5-aminolevulinic acid. EC 4.2.1.24.
Photochemotherapy using visible light, usually red, topically or delivered locally by fiberoptic probe to tissues sensitized with hematoporphyrins.
A conjugated protein which is the oxygen-transporting pigment of muscle. It is made up of one globin polypeptide chain and one heme group.
Inorganic compounds that contain gold as an integral part of the molecule.
A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
An antifungal agent used in the treatment of TINEA infections.
A plant family of the order Cycadales, class Cycadopsida, division CYCADOPHYTA.
Selection of a type of occupation or profession.
Literary and oral genre expressing meaning via symbolism and following formal or informal patterns.
Gloves, usually rubber, worn by surgeons, examining physicians, dentists, and other health personnel for the mutual protection of personnel and patient.
The upward or downward mobility in an occupation or the change from one occupation to another.
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
A publication issued at stated, more or less regular, intervals.
Individual's rights to obtain and use information collected or generated by others.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.

Do charge-remote fragmentations occur under matrix-assisted laser desorption ionization post-source decompositions and matrix-assisted laser desorption ionization collisionally activated decompositions? (1/1552)

The precursor ions of tetraphenylporphyrins that are substituted with fatty acids can be introduced into the gas phase by matrix-assisted laser desorption ionization (MALDI) and undergo post-source and collisionally activated decompositions (CAD) in a time-of-flight mass spectrometer. The goal of the research is to obtain a better understanding of post-source decompositions (PSD); specifically, we asked the question of whether ions undergoing PSD have sufficient energy to give charge-remote fragmentations along an alkyl chain. We chose the porphyrin macrocycle because we expected it to act as an inert "support," allowing the molecule to be desorbed by MALDI and to be amenable to charge-remote fragmentation. MALDI-PSD and MALDI-CAD spectra are similar to high-energy CAD spectra and considerably more informative than low-energy CAD spectra, showing that charge-remote fragmentations of the fatty acid moieties do occur upon MALDI-PSD and MALDI-CAD.  (+info)

High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma. (2/1552)

Benzoporphyrin derivative monoacid ring A (verteporfin, BPD-MA) when intravenously injected (5.5 micromol kg(-1)) to C57/BL6 mice bearing a subcutaneously transplanted B1 melanoma gave a maximal accumulation in the tumour within 1-3 h with recoveries of 1.84-1.96 micromol kg(-1). Irradiation of BPD-MA-loaded melanoma with 690-nm light from a dye laser at 3 h and 9 h post injection induced tumour necrosis and delay of tumour growth of 28 and 14 days respectively. The response of the tumour to BPD-MA photosensitization was enhanced by pretreatment with 1064-nm light from a pulse-operated Nd:YAG laser, which caused a selective breakdown of melanosomes.  (+info)

Ultrastructural changes in PAM cells after photodynamic treatment with delta-aminolevulinic acid-induced porphyrins or photosan. (3/1552)

Photodynamic therapy (PDT) is the combination of a photosensitizing drug (Ps) with light in the presence of oxygen leading to the generation of reactive molecular species and destruction of cancer cells. In this study we compared PDT with two Ps, the hematoporphyrin derivative Photosan (Ph) and delta-aminolevulinic acid (ALA)-induced endogenous protoporphyrin IX, with respect to mitochondrial function and ultrastructural alterations. The effects of PDT were investigated in PAM 212 cells after different Ps incubation times, light doses, and post-treatment periods. Both Ps induced a light dose-dependent impairment of the mitochondrial function with the dose-response curve being steep for ALA and flat for Ph. The prolongation of the incubation time from 4 to 20 h resulted in an increased reduction of mitochondrial activity after ALA PDT but not after Ph PDT. Treatment with an irradiation dose that decreased mitochondrial activity by 50% (IC50) led to early and profound changes of mitochondrial morphology in ALA photosensitized cells, whereas photosensitization with Ph resulted in more pronounced alterations of lysosomes. We conclude that at bioequivalent sublethal PDT exposures of PAM 212 cells, ALA-induced damage is primarily restricted to mitochondria, whereas Ph-induced cytotoxicity is mediated by damage of the lysosomal system.  (+info)

Five-coordinate iron-porphyrin as a model for the active site of hemoproteins. Characterization and coordination properties. (4/1552)

Preparation of iron(III)-deuteroporphyrin 6(7)-methyl ester, 7(6)-(histidine methyl ester) by coupling histidine methyl ester to deuterohemin has been performed using the mixed carboxylic/carbonic-acid-anhydride method. This compound, which is very soluble in various organic solvents, can be considered as a prosthetic group model for the active site of five-coordinate hemoproteins. In the oxidized state a basic, a neutral or an acid form can be isolated. The basic and acid forms are monomeric at all concentrations. The neutral form is found dimeric in concentrated solutions while it is monomeric at low concentration. The coordination state of iron in these various species is investigated. The neutral form reacts with ligands, such as nitrogenous organic bases, leading to six-coordinate well-known hemichromes which exhibit low-spin electron spin resonance (ESR) spectra. The reaction of anionic ligands, such as F-, CN-, NO-2 and N-3, with the neutral form model leads to unsymmetrical six-coordinate complexes whose optical and ESR spectra are similar to those of synthetic deuteromyoglobin. In benzene, toluene or dichloromethane solutions iron (II)-deuteroporphyrin 6(7)-methyl ester, 7(6)-histidine methyl ester), obtained from ferric forms by heterogeneous reduction with aqueous dithionite, exhibits an optical spectrum characteristic of a five-coordinate high-spin ferrous complex. At low temperature important spectral modifications are observed indicating a dimeric association. At room temperature it binds one nitrogenous base molecule leading to the well-known hemochrome. It reacts also with carbon monoxide with a very high affinity constant (4.5 X 10(8) M-1), comparable to that of the isolated human hemoglobin alpha and beta chains, but much higher than the values reported for other various models, suggesting that the side-chain length bearing the fifth ligand may have an important influence upon the reactivity of the sixth position of the iron ion. At low temperature in toluene or dichloromethane, this compound reversibly binds oxygen without oxidation of the iron ion while oxidation occurs at room temperature. The significance of these results is discussed in relation with the local environment, the electronic nature of the base and the immobilization of the heme group in hemoproteins.  (+info)

Reaction of the microsomal heme oxygenase with cobaltic protoporphyrin IX, and extremely poor substrate. (5/1552)

A reconstituted heme oxygenase system which was composed of a purified heme oxygenase from pig spleen microsomes and a partially purified NADPH-cytochrome c reductase from pig liver microsomes could not catalyze the conversion of cobaltic protoporphyrin IX (Co-heme) to biliverdin, although Co-heme could bind with the heme oxygenase protein to form a complex. The heme oxygenase system in the microsomes from pig spleen, rat spleen, and rat kidney also failed to oxidize Co-heme to biliverdin. Properties of the complex of Co-heme and heme oxygenase closely resembled those of cobalt myoglobin and cobalt hemoglobin; the Co-heme bound to the heme oxygenase protein did not react with cyanide and azide, the Co-heme moiety was reduced but only slowly with sodium dithionite, and the reduced form of the Co-heme did not appear to bind carbon monoxide. The co-heme bound to heme oxygenase was not reduced with the NADPH-cytochrome c reductase system in air. These findings further support the views that heme oxygenase may have a heme-binding crevice similar to those of myoglobin and hemoglobin and that reduction of heme is the prerequisite for the oxidative degradation of heme in the heme oxygenase reaction.  (+info)

Optimum porphyrin accumulation in epithelial skin tumours and psoriatic lesions after topical application of delta-aminolaevulinic acid. (6/1552)

Photodynamic therapy with topically applied delta-aminolaevulinic acid is used to treat skin tumours by employing endogenously formed porphyrins as photosensitizers. This study examines the time course of porphyrin metabolite formation after topical application of delta-aminolaevulinic acid. Porphyrin biosynthesis in human skin tumours (basal cell carcinoma, squamous cell carcinoma), in psoriatic lesions, and in normal skin was investigated. Skin areas were treated with delta-aminolaevulinic acid, and levels of total porphyrins, porphyrin metabolites and proteins were measured in samples excised after 1, 2, 4, 6, 9, 12 and 24 h. There was an increase in porphyrin biosynthesis in all tissues with maximum porphyrin levels in tumours between 2 and 6 h and in psoriatic lesions 6 h after treatment. The pattern of porphyrins showed no significant difference between normal and neoplastic skin, protoporphyrin being the predominant metabolite. The results suggest that optimum irradiation time for superficial epithelial skin tumours may be as soon as 2 h after application of delta-aminolaevulinic acid, whereas for treatment of psoriatic lesions an application time of 6 h is more suitable.  (+info)

Carbon monoxide stimulates the apical 70-pS K+ channel of the rat thick ascending limb. (7/1552)

We have investigated the expression of heme oxygenase (HO) in the rat kidney and the effects of HO-dependent heme metabolites on the apical 70-pS K+ channel in the thick ascending limb (TAL). Reverse transcriptase-PCR (RT-PCR) and Western blot analyses indicate expression of the constitutive HO form, HO-2, in the rat cortex and outer medulla. Patch-clamping showed that application of 10 microM chromium mesoporphyrin (CrMP), an inhibitor of HO, reversibly reduced the activity of the apical 70-pS K+ channel, defined by NPo, to 26% of the control value. In contrast, addition of 10 microM magnesium protoporphyrin had no significant effect on channel activity. HO involvement in regulation of the apical 70-pS K+ channel of the TAL, was further indicated by the addition of 10 microM heme-L-lysinate, which significantly stimulated the channel activity in cell-attached patches by 98%. The stimulatory effect of heme on channel activity was also observed in inside-out patches in the presence of 0.5-1 mM reduced nicotinamide adenine dinucleotide phosphate. This was completely abolished by 10 microM CrMP, suggesting that a HO-dependent metabolite of heme mediated the effect. This was further supported by exposure of the cytosolic membrane of inside-out patches to a carbon monoxide-bubbled bath solution, which increased channel activity. Moreover, carbon monoxide completely abolished the effect of 10 microM CrMP on the channel activity. In contrast, 10 microM biliverdin, another HO-dependent metabolite of heme, had no effect. We conclude that carbon monoxide produced from heme via an HO-dependent metabolic pathway stimulates the apical 70-pS K+ channel in the rat TAL.  (+info)

A corrinoid-dependent catabolic pathway for growth of a Methylobacterium strain with chloromethane. (8/1552)

Methylobacterium sp. strain CM4, an aerobic methylotrophic alpha-proteobacterium, is able to grow with chloromethane as a carbon and energy source. Mutants of this strain that still grew with methanol, methylamine, or formate, but were unable to grow with chloromethane, were previously obtained by miniTn5 mutagenesis. The transposon insertion sites in six of these mutants mapped to two distinct DNA fragments. The sequences of these fragments, which extended over more than 17 kb, were determined. Sequence analysis, mutant properties, and measurements of enzyme activity in cell-free extracts allowed the definition of a multistep pathway for the conversion of chloromethane to formate. The methyl group of chloromethane is first transferred by the protein CmuA (cmu: chloromethane utilization) to a corrinoid protein, from where it is transferred to H4folate by CmuB. Both CmuA and CmuB display sequence similarity to methyltransferases of methanogenic archaea. In its C-terminal part, CmuA is also very similar to corrinoid-binding proteins, indicating that it is a bifunctional protein consisting of two domains that are expressed as separate polypeptides in methyl transfer systems of methanogens. The methyl group derived from chloromethane is then processed by means of pterine-linked intermediates to formate by a pathway that appears to be distinct from those already described in Methylobacterium. Remarkable features of this pathway for the catabolism of chloromethane thus include the involvement of a corrinoid-dependent methyltransferase system for dehalogenation in an aerobe and a set of enzymes specifically involved in funneling the C1 moiety derived from chloromethane into central metabolism.  (+info)

TY - JOUR. T1 - The effect of β-saturated pyrrolic rings on the electronic structures and aromaticity of magnesium porphyrin derivatives. T2 - A density functional study. AU - Wan, Liang. AU - Qi, Dongdong. AU - Zhang, Yuexing. PY - 2011/1/1. Y1 - 2011/1/1. N2 - Density functional theory (DFT) calculation on the molecular structures, molecular orbitals, electronic absorption spectra, and magnetic properties of magnesium porphyrin (MgPor) and a series of five hydrogenated magnesium porphyrin complexes with different number of β-saturated pyrrolic rings, namely MgPor-β-1Hy, MgPor-β-opp-2Hy, MgPor-β-adj-2Hy, MgPor-β-3Hy, and MgPor-β-4Hy, clarifies the redshift of the lowest energy absorption band from chlorophyll a to bacteriochlorophyll and reveals the strong chemical stability for both of them. The energy levels of highest occupied molecular orbitals (HOMO) and HOMO-1 for MgPor are reversed upon hydrogenation at β-positions (2 and 3, 7 and 8, 12 and 13, and 17 and 18) of porphyrin ring. ...
Abstract: 5fluorouracil porphyrin compounds are a new type of potential antitumor drugs. Six new 5fluorouracil porphyrin compounds were synthesized first and characterized by means of elemental analysis, IR, 1HNMR and MS. The six 5fluorouracil porphyrin compounds were studied by absorption spectra, steadystate fluorescence spectroscopy and timeresolved single photon measurement, comparing with their primary porphyrin compounds. The 5fluorouracil porphyrin compounds with plentiful excited states and fluorescence lifetime of 7 ns are little influenced by substituents and solvents, which may be advantageously used to make singlet oxygen radical. Key words: 5-fluorouracil, Porphyrin, Fluorescence lifetime, Single photon measurement ...
0151]Examples of metalloporphyrins include cobalt meso-tetra-(4-N-methylpyridyl)-porphine; cobalt (II) meso(4-sulfonatophenyl)-porphine; copper hematoporphyrin; copper meso-tetra-(4-N-methylpyridyl)-porphine; copper (II) meso(4-sulfonatophenyl)-porphine; Europium (III) dimethyltexaphyrin dihydroxide; gallium tetraphenylporphyrin; iron meso-tetra(4-N-methylpyridyl)-porphine; lutetium (III) tetra(N-methyl-3-pyridyl)-porphyrin chloride; magnesium (II) meso-diphenyl tetrabenzoporphyrin; magnesium tetrabenzoporphyrin; magnesium tetraphenylporphyrin; magnesium (II) meso(4-sulfonatophenyl)-porphine; magnesium (II) texaphyrin hydroxide metalloporphyrin; magnesium meso-tetra-(4-N-methylpyridyl)-porphine; manganese meso-tetra-(4-N-methyl-pyridyl)-porphine; nickel meso-tetra(4-N-methylpyridyl)-porphine; nickel (II) meso-tetra(4-sulfonatophenyl)-porphine; palladium (II) meso-tetra-(4-N-methylpyridyl)-porphine; palladium meso-tetra-(4-N-methylpyridyl)-porphine; palladium tetraphenylporphyrin; palladium (II) ...
TY - JOUR. T1 - Novel Photocatalytic Function of Porphyrin-Modified Gold Nanoclusters in Comparison with the Reference Porphyrin Compound. AU - Fukuzumi, Shunichi. AU - Endo, Yoshiyuki. AU - Kashiwagi, Yukiyasu. AU - Araki, Yasuyuki. AU - Ito, Osamu. AU - Imahori, Hiroshi. PY - 2003/10/30. Y1 - 2003/10/30. N2 - The photocatalytic function of three-dimensional porphyrin monolayer-protected gold clusters (MFCs) with different chain lengths has been examined in photocatalytic reduction of hexyl viologen (HV2+) by 1-benzyl-1,4-dihydronicotinamide (BNAH) in comparison with that of the reference porphyrin compound without metal clusters. Both porphyrin monolayer-protected gold clusters and the reference porphyrin compound act as efficient photocatalysts for the uphill reduction of HV2+ by BNAH to produce 1-benzylnicotinamidinium ion (BNA+) and hexyl viologen radical cation (HV•+) in benzonitrile. In the case of porphyrin monolayer-protected gold clusters the quantum yield reaches a maximum value ...
The purpose of this study is to gain a better understanding of the parameters governing the synthesis of meso-substituted porphyrins. As a result of doing so, we anticipate that better reaction conditions can be developed, which will afford porphyrins in higher yields. Porphyrins are a large class of deeply colored red or purple, fluorescent crystalline pigments, of natural or synthetic origin, having in common a substituted aromatic macrocyclic ring consisting of four pyrrole-type residues, linked together by four methine bridging groups. The structure of porphyrin has been known since the early 1900s, but discrepancies exist on how the formation of porphyrin actually occurs. Several methods have been developed for the porphyrin reaction under various conditions. Three of the most common methods for the synthesis of meso-substituted porphyrins are: the Rothemund Method, the Adler Method, and the Lindsey Method. The conditions for these reactions vary from the harsh conditions where the ...
Water-soluble, meso-substituted porphyrins are synthesized by sulfonation or methylation of the phenyl or pyridyl groups, respectively, of some non-water-soluble functionalized porphyrins that we have recently synthesized (Can. J. Chem. 72, 1894 (1994)). Twelve anionic sulfonated and seven cationic methylpyridinium porphyrins, usually containing other functional groups (phenyl, pyridyl, nitro- and amino-phenyl), are reported on. Twelve of these porphyrins are new, and all nineteen porphyrins are characterized by H-1 NMR. UV-VIS data are presented for the isolated porphyrins, while mass spectral data are noted for selected compounds. Partition coefficients of the porphyrins in octanol-water, and the accumulation of the porphyrins in HT-29 cells of a human-cancer tumor, were measured and both were inversely related to the charges of the porphyrins. The 11 porphyrins soluble in biological buffer solutions are basically nontoxic to Chinese hamster ovary (CHO) cells in oxic or hypoxic conditions or ...
TY - JOUR. T1 - Early-stage HIV infection and hepatitis C virus infection are associated with elevated serum porphyrin levels. AU - Lim, H. W.. AU - Pereira, A.. AU - Sassa, S.. AU - Kim, Mimi. AU - Zolla-Pazner, S.. PY - 1998. Y1 - 1998. N2 - Background: Porphyria cutanea tarda is known to be associated with HIV infection and hepatitis C virus (HCV). Objective: Our purpose was to evaluate whether early infection with HIV, with or without HCV infection, is associated with elevated serum porphyrin levels. Methods: Serum porphyrin levels were measured in samples obtained from 103 patients with early HIV infection. The results were compared with those of 89 late-stage HIV-positive patients and 78 HIV-negative patients. Results: The highest median porphyrin level was in early-stage HIV-positive/HCV-positive samples, followed in decreasing order by those in early-stage HIV-positive/HCV-negative, late- stage HIV-positive/HCV-positive, late-stage HIV-positive/HCV-negative, HIV- negative/HCV-positive, ...
Porphyrin-cn web supplied various porphyrin卟啉催化剂, containing fluorescence porphyrin porphine 917-23-7 & Fe porphyrin Mn porphyrin Cu porphyrin Co porphyrin Ni porphyrin Zn porphyrin & metalloporphyrin
Porphyrin-cn web supplied various porphyrin卟啉催化剂, containing fluorescence porphyrin porphine 917-23-7 & Fe porphyrin Mn porphyrin Cu porphyrin Co porphyrin Ni porphyrin Zn porphyrin & metalloporphyrin
In this work the aggregates of the tetrakis(4-sulfonatophenyl)porphyrin (TPPS4) growth from solution on solid crystalline hydrophilic and hydrophobic substrates were investigated. The spatial structure of TPPS4 deposited on the surface was imaged using Transmission Electron Microscopy (TEM), Scanning Atomic Force Microscopy (AFM). Scanning Tunnelling Microscopy (STM) visualized porphyrin rings structure with molecular resolution. The aggregation of TPPS4 was investigated by UV_VIS spectroscopy. The TEM investigation revealed a 3-dimensional rod and wheel like molecular order of the TPPS4 porphyrin assemblies, while a corresponding shorter and monodisperse oligomer exhibited 2D ribbon-like structure. The TPPS4 porphyrin molecules self-assemble into micrometer-long nanorods and fibers on substrate surface. Their cross section was determined quantitatively by scanning force microscopy. This revealed a typical thickness of two or four molecular layers and a width of tenths of molecule diameter. This
Selective inhibitors of voltage-activated K+ channels are needed for the treatment of multiple sclerosis. In this work it was discovered that porphyrins bearing 2-4 carbon alkyl ammonium side chains predominantly blocked the Kv1.1 current whilst Kv1.2 was susceptible to a porphyrin bearing polyamine side chains.. ...
Free base stannyl porphyrins and free base porphyrin dimers have been successfully synthesized via copper-free Stille coupling in 21−67% yields. This approach provides an access to stannyl porphyrin synthons that were previously unavailable. Moreover, variation of the reaction conditions selectively provides access to either stannyl porphyrins or porphyrin dimers. Full 119/117Sn NMR analysis was used for characterization of the stannyl porphyrins and detailed 119Sn-1H-13C NMR analyses were carried out on a series of the starting tin reagents and the stannyl porphyrins. These investigations indicate that significant structural information can be gathered by use of commonly known NMR techniques. Photophysical properties of the novel porphyrins prepared including absorption, emission, and fluorescence lifetimes were investigated. The stannyl porphyrins emitted in the visible region, and in all cases large Stokes shifts were observed. The emission intensities of the stannyl porphyrins were ...
299057642 - EP 0785941 B1 2000-04-19 - PORPHYRIN LABELING OF POLYNUCLEOTIDES - [origin: WO9611937A1] The invention provides various porphyrin labeled compounds and reagents for labeling molecules with porphyrins. The porphyrin labeled compounds include porphyrin labeled nucleosides, nucleotides, polynucleotides and the like. The porphyrin labeled compounds of the invention are designed so that the porphyrin moiety on the labeled compound may be detected on the basis of a reaction product produced by the porphyrin catalyzed oxidation of a porphyrin detection reagent. The oxidation of the porphyrin detection reagent may result in the formation of light, i.e., a chemiluminescent reaction, or a colored compound, i.e., a colorimetric reaction. The compounds of the invention contain the general structure of: porphyrin-linker-base-sugar-(phos)n-OH. Another aspect of the invention is to provide methods of labeling and detecting polynucleotides by incorporating a porphyrin-labeled nucleotide into a
TY - JOUR. T1 - Design of Spatial Disposition of Anionic Porphyrins in Matrices of Ammonium Bilayer Membranes. AU - Ishikawa, Yuichi. AU - Kunitake, Toyoki. PY - 1991/1/1. Y1 - 1991/1/1. N2 - A methodology to place charged porphyrin derivatives in specific spatial arrangements in matrices of ammonium bilayer membranes was explored. Aqueous mixtures of anionic copper(II) porphyrins and bilayer dispersions of single-chain and double-chain ammonium amphiphiles were cast on Teflon sheets to produce regular multilayer films. The orientation of doped copper(II) porphyrins was determined by anisotropies of ESR spectral patterns that were dependent on the disposition of the cast film in the magnetic field. Quantitative estimates of the porphyrin orientation were made possible by elaborate computer simulation of the observed spectra. The mode of porphyrin orientation is determined by the distribution of anionic substituents on guest porphyrins and the supramolecular structure of host bilayers. Type III ...
The ability of a novel porphyrin, meso-tetrakis[3,4-bis(carboxymethyleneoxy)phenyl]porphyrin (T3,4-CPP), to induce photodamage in subcellular membranes, in the form of rat hepatic and tumor microsomes, was evaluated with a view to locating suitable porphyrin derivative for possible use in photodynamic therapy. This water-soluble porphyrin, on exposure to visible light, induced a significant extent of membrane lipid peroxidation as assessed by the formation of thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes. The peroxidation induced in hepatic microsomes is both time-and concentration-dependent. Using inhibitors of reactive oxygen species and comparing products of peroxidation, it is shown that the damage induced is mainly due to singlet oxygen and partly due to other species like free radicals. T3,4-CPP also caused the generation of singlet oxygen as a function of illumination time. Since membrane damage induced by a sensitizer on photoexcitation has been ...
The photophysical properties of a ring B benzoporphyrin derivative 1,3-diene dimethylester were investigated in solution (water-DMSO mixtures). At low proportions of water in DMSO, the diester obeys Beers law at all pH values and ionic strengths investigated. For solvent systems containing more than 30% water, the extent of deviation from Beers law as a function of porphyrin concentration is attributed to formation of porphyrin dimers. Dimerization equilibrium constants (Kd) have been determined in different percentage of solvent mixtures, using absorption and fluorescence spectroscopies, and were found to exhibit a linear correlation between log (Kd) and the inverse of the dielectric constant (log (Kd) = 24.6 - 1060.4 x 1/epsilon (mix)). This equation permits the calculation of Kd in mixtures of water-DMSO.. ...
The present invention relates to metallized porphyrin derivatives having the formula: ##STR1## wherein the R and M variables are as defined in the specification. Said porphyrin derivatives having uses as antitumor agents, diagnostics agents, or in therapy.
TY - JOUR. T1 - Singlet and triplet excited states of emissive, conjugated bis(porphyrin) compounds probed by optical and EPR spectroscopic methods. AU - Shediac, Renée. AU - Gray, Mike H.B.. AU - Tetsuo Uyeda, H.. AU - Johnson, Robert C.. AU - Hupp, Joseph T.. AU - Angiolillo, Paul J.. AU - Therien, Michael J.. PY - 2000/7/26. Y1 - 2000/7/26. N2 - The nature of the singlet and triplet excited states of a series of meso-to-meso ethyne-linked bis(porphyrin) compounds was probed by electronic absorption, polarized pump - probe fluorescence, electron paramagnetic resonance (EPR), electroabsorption (Stark), and transient triplet - triplet absorption spectroscopic methods, Pump - probe fluorescence anisotropy experiments show that the presence of meso-ethynyl substituents drives a reorientation of orthogonal x- and y-polarized singlet excited states in the macrocycle frame of reference with respect to that evinced for conventional free-base porphyrin chromophores. Analogous experiments in conjugated ...
The activation parameters and the rate constants of the water exchange reactions of MnTE-2-PyP5+ (Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin) as cationic, MnTnHex-2-PyP5+ (Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)-porphyrin) and MnTTEG-2-PyP5+ (Mn(III) meso-tetrakis(N-tri(ethyleneglycol)-pyridinium-2-yl)porphyrin) as sterically shielded cationic, and MnTSPP3- (meso-tetrakis(4-sulfonatophenyl)porphyrin) as anionic Mn(III) porphyrins have been determined from the temperature dependence of 17O NMR relaxation rates. On the basis of the determined entropies of activation, an interchange-dissociative mechanism (Id) was proposed for the cationic complexes (ΔS‡ = ca. 0 J K-1 mol-1) whereas a limiting dissociative mechanism (D) was proposed for MnTSPP3- complex (ΔS‡ = +79 J K-1 mol-1). We found that the in vitro autoxidation of N-hydroxyurea (HU) is catalyzed by MnTTEG-2-PyP5+, which is also a potent mimic of the enzyme superoxide dismutase. The detailed mechanism of the reaction ...
TY - JOUR. T1 - Effect of meso substituents on exchange-coupling interactions in μ-oxo iron(III) porphyrin dimers. AU - Helms, Jeffrey H.. AU - Ter Haar, Leonard W.. AU - Hatfield, William E.. AU - Harris, David L.. AU - Jayaraj, K.. AU - Toney, Glen E.. AU - Gold, Avram. AU - Mewborn, Tabitha D.. AU - Pemberton, Jeanne E. PY - 1986. Y1 - 1986. N2 - The μ-oxo iron(III) porphyrin dimers [(TPP)Fe]2O, [(TPP(4-OCH3))Fe]2O, [(TPP(4-CF3))Fe]2O, and [(TPP(F5))Fe]2O (where TPP is meso-tetraphenylporphyrin, TPP(4-OCH3) is meso-tetrakis(4-methoxyphenyl)porphyrin, TPP(4-CF3) is meso-tetrakis(4-(trifluoromethyl)phenyl)porphyrin, and TPP(F5) is meso-tetrakis(pentafluorophenyl)porphyrin) have been studied to determine the effect of peripheral substituents on the porphyrin rings on properties of the molecules. Variable-temperature magnetic susceptibility studies on solid samples yielded the following exchange-coupling constants for the antiferromagnetically coupled iron(III) ions: -146.8 cm-1, ...
Numerous studies have been conducted using porphyrin molecules on various substrates to investigate their diverse photoelectrochemical, catalytic, electronic, and biochemical properties. These properties make porphyrin molecules targets for use as active components in devices such as chemical sensors, information storage, and photo sensitizers in solar cells. In this study, we investigated the assembly and aggregation of mono-podal zinc (II) porphyrin molecules into a dodecanethiol self-assembled monolayer (SAM) on gold. The porphyrin macrocycle is attached to a phenyl linking group and an alkanethiol tether which binds to the gold surface. The charge transport properties of the porphyrin in confined geometries are being investigated based on previous studies of aggregated assemblies on gold surfaces. In these studies, we find small islands of porphyrins to produce unique electrical switching behavior not observed in single molecules. To explore how island size influences the electrical ...
The ability to replace the native heme cofactor of proteins with an unnatural porphyrin of interest affords new opportunities to study heme protein chemistry and engineer heme proteins for new functions. Previous methods for porphyrin substitution rely on removal of the native heme followed by porphyrin reconstitution. However, conditions required to remove the native heme often lead to denaturation, limiting success at heme replacement. An expression-based strategy for porphyrin substitution was developed to circumvent the heme removal and reconstitution steps, whereby unnatural porphyrin incorporation occurs under biological conditions. The approach uses the RP523 strain of Escherichia coli, which has a deletion of a key gene involved in heme biosynthesis and is permeable to porphyrins. The expression-based strategy for porphyrin substitution detailed here is a robust platform to generate heme proteins containing unnatural porphyrins for diverse applications ...
Hematoporphyrin IX dimethyl ester (HPDME), tetraphenylporphyrin (TPP), tetra(4-methoxyphenyl)porphyrin (TMPP), tetra(3,4-dimethoxyphenyl)porphyrin (TDMPP), tetra(3,4,5-trimethoxyphenyl)porphyrin (TTMPP), tetraanthrylporphyrin (TAP) and tetraacridylporphyrin (TACP), and their Zn2+, SnX2(2+), Pd2+ and Pt2+ complexes have been prepared and characterized. The singlet molecular oxygen quantum yield (phi(DELTA)) values of the above porphyrins and their metal derivatives in N,N-dimethyl formamide (DMF) have been measured in the presence of 1, 3-diphenylisobenzofuran (DPBF) as O-1(2) acceptor using steady state technique after correcting for the intensity of light absorbed by the photosensitizers. The phi(DELTA) values for the free base porphyrins are usually around 0.60. Hematoporphyrin IX dimethyl ester and its metal derivatives follow the order: HPDME (phi(DELTA) = 0.60) , Zn HPDME (0.40) , PdHPDME (0.34) , Sn(OH)2HPDME (0.28) greater-than-or-equal-to PtHPDME (0.24). Zinc(II) complexes of ...
The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic.
Fingerprint Dive into the research topics of Chiroptical properties of anionic and cationic porphyrins and metalloporphyrins in complex with left-handed Z-DNA and right-handed B-DNA. Together they form a unique fingerprint. ...
ABSTRACT Electrochemical studies of the oxidation of dodecasubstitued and highly nonplanar nickel porphyrins in a non-coordinating solvent have previously revealed the first NiIII porphyrin dication. Herein, we investigate if these nonplanar porphyrins can also be used to detect the so far unobserved CuIII porphyrin dication. Electrochemical studies of the oxidation of (DPP)M and (OETPP)M show three processes, the first two of which are macrocycle centered to give the porphyrin dication followed by a CuII/III processes at more positive potential. Support for the assignment of the CuII/III process comes from the linear relationships observed between E1/2 and the third ionization potential of the central metal ions for Fe, Co, Ni and Cu complexes of (DPP)M and (OETPP)M. In addition, the oxidation behaviour of additional nonplanar nickel porphyrins is investigated in a non-coordinating solvent, with nickel meso-tetraalkylporphyrins also being found to form NiIII porphyrin dications. Finally, ...
We compared antioxidant responses and regulation of porphyrin metabolism in rice plants treated with oxyfluorfen (OF) or methyl viologen (MV). Plants treated with MV exhibited not only greater increases in conductivity and malondialdehyde but also a greater decline in Fv/Fm, compared to plants treated with OF. MV-treated plants had greater increases in activities of superoxide dismutase (SOD) and catalase (CAT) as well as transcript levels of SODA and CATA than OF-treated plants after 28 h of the treatments, whereas increases in ascorbate peroxidase (APX) activity and transcript levels of APXA and APXB were greater in OF-treated plants. Both OF- and MV-treated plants resulted in not only down-regulation of most genes involved in porphyrin biosynthesis but also disappearance of Mg-porphyrins during the late stage of photooxidative stress. By contrast, up-regulation of heme oxygenase 2 (HO2) is possibly part of an efficient antioxidant response to compensate photooxidative damage in both treatments. Our
Porphyrins are organic aromatic compounds composed of four pyrrole rings interconnected to each other and to the Fe2+ ion. Porphyrins are essential cofactors of many proteins including cytochrome proteins and haemoglobin and myoglobin in humans. The first step in the production of porphyrin in animals is the mitochondrial formation of delta-aminolevulinate from glycine and succinyl-CoA. In humans, this aminolevulinate is then transported to cytosol where the 4-step conversion into Coproporphyrinogen III occurs. The remaining processing of this intermediate to protoporphyrin IX and then to heme takes place in mitochondrion.. The cytochrome proteins in Plasmodium and Coccidian species such as Toxoplasma and Neospora require de novo synthesis of porphyrin. Although P. falciparum obtains heme from host haemoglobin digestion, it cannot utilise them for biosynthesis of its own porphyrin-containing proteins [1] and converts them to hemozoin [2]. The enzymes of de novo heme biosynthesis in P. falciparum ...
Key words: Organic photosensitizer, natural porphyrin, titanium dioxide anatase, phorocurrent Abstract: A set of organic photodetector devices arranged as indium doped tin oxide (TTO)/porphyrin/TiOialuminum has been fabricated and its performance has been tested in dark and under various illumination of visible light intensity from 20-100 mW/cm2. Four devices were prepared using natural porphyrin by I, 3, 5 and 7 times of spin coating. First, porphyrin film was deposited onto indium doped tin oxide (!TO)-covered glass substrate by spin coating technique. Second, titanium dioxide (Ti02) film was deposited on top of the porphyrin film using similar technique. Porphyrin was isolated from spirulina microalgae and Ti02 nanoparticle was prepared by controlled hydrolysis technique using titanium(IV) etoxide, Ti(OC2Hj)4, and potassium chloride. The films were characterized by UV-vis spectrophotometer to investigate their absorption spectra. The porphyrin film has maximum absorbance at 660 nm, which is ...
Fingerprint Dive into the research topics of Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure. Together they form a unique fingerprint. ...
The photoreduction of water-soluble cationic manganese (III) meso-tetrakis (1-methylpyridium-4-yl)porphyrin (Mn-III(TMPyP)(4+)) bound to a synthetic polynucleotide, either poly[d(A-T)(2)] or poly[d(G-C)(2)], was examined by conventional absorption and circular dichroism (CD) spectroscopy, transient absorption, and transient Raman spectroscopy. Upon binding, Mn-III(TMPyP)(4+) produced a positive CD signal for both polynucleotides, suggesting external binding. In the poly[d(A-T)(2)]-Mn-III(TMPyP)(4+) adduct case, an interaction between the bound porphyrin was suggested. The transient absorption spectral features of Mn-III(TMPyP)(4+) in the presence of poly[d(A-T)(2)] and poly[d(G-C)(2)] were similar to those of the photoreduced products, Mn-II(TMPyP)(4+), whereas Mn-III(TMPyP)(4+) in the absence of polynucleotides retained its oxidation state. This indicated that both poly[d(A-T)(2)] and poly[d(G-C)(2)] act as electron donors, resulting in photo-oxidized G and A bases. The transient Raman bands ...
This work uncovers the application of porphyrin dimers for the use in electroanalysis, such as potentiometric determination of ions. It also puts in question a current perception of an occurrence of the super-Nernstian response, as a result of the possible dimerization of single porphyrins within an ion-selective membrane. To study that, four various porphyrin dimers were used as ionophores, namely, freebase-freebase, Zn-Zn, Zn-freebase, and freebase-Zn. Since the Zn-freebase and freebase-Zn porphyrin dimers carried both anion- and cation-sensitive porphyrin units, their application in ISEs was utilized in both anion- and cation-sensitive sensors. With respect to the lipophilic salt added, both porphyrins dimers were found anion- and cation-sensitive. This allowed using a single molecule as novel type of versatile ionophore (anion- and cation-selective), simply by varying the membrane composition. All anion-sensitive sensors were perchlorate-sensitive, while the cation-selective sensors were ...
Mixed metallo-porphyrin cages were selected and amplified from dynamic combinatorial libraries (DCLs) by using appropriate templates. The cages are composed of two bisphosphine substituted zinc(II) porphyrins as ligand donors and two rhodium(III) or ruthenium(II) porphyrins as ligand acceptors, and are connected through metal-phosphorus coordination. Ru and Rh porphyrins that display a large structural diversity were employed. The templating was achieved by using 4,4-bpy, 3,3-dimethyl-4,4-bipyridine and benzo[lmn]-3,8-phenanthroline, and acts through zinc-nitrogen coordination. The absolute amount of amplification from the DCLs is strongly dependent on the combination of the Ru/Rh porphyrin and the template; cages with sterically demanding porphyrins can only form with smaller templates. In the case of tert-butyl-substituted TPP (TPP=tetraphenylporphyrin), cages are not formed at all. The formation of the cages is usually complete within 24 h at an ambient temperature; in the case of the cage ...
Table of contents 1. Report Introduction. 2. Myc Proto Oncogene Protein 3. Myc Proto Oncogene Protein Current Treatment Patterns. 4. Myc Proto Oncogene Protein - DelveInsights Analytical Perspective. 5. Therapeutic Assessment. 6. Myc Proto Oncogene Protein Late Stage Products (Phase-III). 7. Myc Proto Oncogene Protein Mid Stage Products (Phase-II). 8. Early Stage Products (Phase-I). 9. Pre-clinical Products and Discovery Stage Products. 10. Inactive Products. 11. Dormant Products. 12. Myc Proto Oncogene Protein Discontinued Products. 13. Myc Proto Oncogene Protein Product Profiles. 14. Myc Proto Oncogene Protein Key Companies. 15. Myc Proto Oncogene Protein Key Products. 16. Dormant and Discontinued Products. 17. Myc Proto Oncogene Protein Unmet Needs. 18. Myc Proto Oncogene Protein Future Perspectives. 19. Myc Proto Oncogene Protein Analyst Review 20. Appendix. 21. Report Methodology. Request Sample Pages @ Myc Proto Oncogene Protein Clinical Trials. Media Contact ...
0020] In one preferred embodiment, the green porphyrin is prepared as a liposomal formulation. Liposomal formulations are believed to deliver the green porphyrin selectively to the low-density lipoprotein component of plasma which, in turn acts as a carrier to deliver the active ingredient more effectively to the neovasculature. Increased numbers of LDL receptors have been shown to be associated with neovascularization, and by increasing the partitioning of the green porphyrin into the lipoprotein phase of the blood, it appears to be delivered more efficiently to the neovasculature. Green porphyrins, and in particular BPD-MA, strongly interact with such lipoproteins. LDL itself can be used as a carrier, but LDL is considerably more expensive and less practical than a liposomal formulation. LDL, or preferably liposomes, are thus preferred carriers for the green porphyrins since green porphyrins strongly interact with lipoproteins and are easily packaged in liposomes. Compositions of green ...
Thermal water treatment with temperatures higher than 50 °C, UV radiation, use of disinfectants, and treatment with chlorine, ozone or chlorodium oxide are the basic techniques for the removal of Legionella from water systems (Kuchta et al. 1985; Bédard et al. 2016). Despite the implementation of all these methods, legionellosis is becoming more frequent, so it is necessary to use new approaches in water disinfection. One of the new approaches is the use of antimicrobial photodynamic therapy (aPDT) as a disinfection method of tap water. The effect of the recently described cationic porphyrin with lipophilic moiety was investigated to determine its antibacterial activity against the opportunistic plumbing pathogen Legionella in its natural environment, tap water. A recent overview of the development and use of amphiphilic porphyrins in PDT emphasized the need for further investigation of cationic porphyrins with different lipophilic moieties as this class of compounds has shown a promising ...
TY - JOUR. T1 - Near-field spectroscopy of water-soluble and water-insoluble porphyrin J-aggregates. AU - Nagahara, Tetsuhiko. AU - Imura, Kohei. AU - Okamoto, Hiromi. PY - 2004/11/1. Y1 - 2004/11/1. N2 - Mesoscopic properties of J-aggregates of water-soluble [tetrakis(4- sulfonatophenyl)porphyrin] and water-insoluble [tetrakis(4-methoxyphenyl) porphyrin and tetraphenylporphyrin] tetraphenylporphyrin derivatives in thin films have been investigated by scanning near-field optical microscopy. From surface topography, the sample films were found to be composed of planar J-aggregate microcrystallines. The transmittance spectra of the water-insoluble samples are site specific, while those of the water-soluble samples are not. This observation might reflect the spatial inhomogeneity of the thin films in mesoscopic scales and is related to the broad J-bands of water-insoluble samples. Excited state lifetimes, obtained from time-resolved, pump-probe measurements in small domains, were in the 30-70 ps ...
Porphyrins are tetrapyrrolic aromatic macrocycles and ubiquitous in nature. They are excellent dyes with strong absorption in the visible region (400�700 nm) and they exhibit decent fluorescence in the red region (620�900 nm). Carbazole is a nitrogen-containing electron rich aromatic heterocycle which can be linked to porphyrins and other chromophores. This review provides an overview of the different synthetic strategies that have been employed to prepare carbazole-substituted porphyrins and carbazole-fused porphyrinoids and similar systems. It also shows that how the substitution of carbazole occurs on the porphyrin core can alter its optical and electronic features. Introduction of carbazole moieties in the porphyrin ring resulted in fused porphyrinoids with changed aromaticity and significantly altered electronic features of the molecules ...
The chemistry of boron porphyrins, which are unique in containing two boron atoms per porphyrin ligand. Highlights have been the development of a series of complexes, a diboryl porphyrin, a diboranyl porphyrin containing a B-B bond which forms through spontaneous reductive coupling of the diboryl under certain conditions ...
Recently, we have characterized the DNA and nucleoprotein (NP) binding of bis(4-N-methylpyridyl)-15,20-di(4-carboxyphenyl)porphyrin (BMPCP) and meso-tri(4-N-methylpyridyl)-mono(4-carboxyphenyl)porphyrin (TMPCP) and their tetrapeptide conjugates (BMPCP-4P2 and TMPCP-4P, respectively). In this work, we investigated the interaction of TMPCP conjugated to the tetrapeptide branches of branched chain polymeric polypeptide with poly-l-lysine backbone (AK) with DNA or NP using spectroscopic methods. Analysis of absorption spectra revealed the external binding but no intercalation of TMPCP-AK to DNA. There was no evidence for the interaction between TMPCP-AK and encapsidated DNA. Furthermore, we examined the cellular uptake of BMPCP and TMPCP and their tetra- or polypeptide conjugates by flow cytometry and analyzed how charge, size, and structure of the compounds affect their incorporation. In comparison, liposomal association constants of these derivatives were determined. BMPCP-4P2 accumulated the ...
A methodology is reported for the regioselective nitration of the phenyl groups of Halterman porphyrin, using NaNO2. These nitro-porphyrins can be reduced to aminoporphyrins and then N-dimethylated to give new optically active porphyrins. Applications to the asymmetric epoxidation of styrene derivatives by H2O2 to give optically active epoxides (ee up to 60%) and hydroxylation of alkanes to give optically active secondary alcohols (ee up to 69%) were carried out in organic solvents (dichloromethane/methanol) using chiral iron and manganese porphyrins as catalysts.
King-Smith, Christina, Laura Black, Matthew Mawhinney, Jan Habdas, and Piotr Habdas. Cytotoxicity of a Novel Porphyrin Compound with Potential for Use in Photodynamic Therapy. Amer. Soc. of Cell Biology. San Francisco. Dec. 2008. Conference Presentation.. ...
TY - JOUR. T1 - Nanostructured assembly of porphyrin clusters for light energy conversion. AU - Hasobe, Taku. AU - Imahori, Hiroshi. AU - Fukuzumi, Shunichi. AU - Kamat, Prashant V.. PY - 2003/10. Y1 - 2003/10. N2 - Free base porphyrin molecules form well-defined and ordered nanoclusters in mixed solvents with absorption characteristics that significantly differ from those of the monomer form. These self-assembled crystallites in acetonitrile/toluene (9:1, v/v) can be deposited as thin films on a nanostructured TiO2 electrode using an electrophoretic technique. This porphyrin cluster assembly is highly photoactive and capable of undergoing charge separation under visible light excitation. Photoexcitation of the porphyrin film electrode assembly in a photoelectrochemical cell with visible light produces relatively high photocurrent generation. A maximum photocurrent of 0.15 mA cm-2 and a photovoltage of 250 mV were attained using the I3-/I- redox couple. The electron flow to the TiO2 electrode ...
Organic compounds that interact both with certain biological targets and display specific photophysical properties can be utilized as molecular tools to visualize and possibly effect disease related processes taking place in living organisms. In this regard, porphyrins are a class of naturally occurring molecules that possess intriguingly interesting photophysical properties where they can act as luminescent probes by emitting detectable light, as well as photosensitizers in the light mediated therapy called photodynamic therapy. In this thesis, the porphyrin structure has been synthetically combined with other molecule classes to achieve compounds with desirable multimodal characteristics.. Firstly, luminescent conjugated oligothiophenes (LCOs) that have extensively, and with great success, been utilized as fluorescent ligands for amyloid formations, have been conjugated to porphyrins to render oligothiophene porphyrin hybrids (OTPHs) comprising two optically active modalities. When applied as ...
The coordination chemistry of Rh(III) porphyrin was outlined by Sadasivan and Fleischer in 1967.199,200 Their Rh(III) porphyrin, obtained by a metallation reaction using [Rh(CO)2Cl]2 and aerial oxidation, was believed to coordinate a labile water molecule which could be displaced by pyridine. A coordinated chloride counterion could be exchanged for azide, cyanide or hydroxide. Work by other groups has demonstrated that six coordinate Rh(III) porphyrins with two identical axial ligands may be generated by reaction of Rh(III)Cl porphyrins (OEP, TPP) with Ag+ to remove the chloride anion, followed by treatment with ligands such as BuNC, PPh2Me and POMe3.201,290 Reaction of Rh(III)Cl porphyrins with organolithium reagents232 or metal carbonylate anions202 afforded organometallic and metal-metal bonded derivatives respectively. The [(OEP)Rh]+ intermediate formed by treatment of (OEP)RhCl with AgBF4 was found to be active in electrophilic aromatic substitution reactions to afford s-bonded Rh aryl ...
TY - JOUR. T1 - Directly Diphenylborane-Fused Porphyrins. AU - Fujimoto, Keisuke. AU - Oh, Juwon. AU - Yorimitsu, Hideki. AU - Kim, Dongho. AU - Osuka, Atsuhiro. PY - 2016/2/24. Y1 - 2016/2/24. N2 - Mono- and bis(diphenylborane)-fused porphyrins were synthesized from the corresponding β-(2-trimethylsilylphenyl)-substituted porphyrins through the sequence of Si-B exchange reaction, intramolecular bora-Friedel-Crafts reaction, and ring-closing Si-B exchange reaction. Effective electronic interactions of the empty p-orbital of the boron atom with the porphyrin π-circuit lead to red-shifted absorption spectra and substantially decreased LUMO energy levels. Pyridine adds at the boron center to cause disruption of the electronic interaction of the boron atom with large association constants (1.9-17×104 m−1) depending on the central metal at the porphyrin. The ZnII complex behaved as a hetero-dinuclear Lewis acid, exhibiting regioselective binding of pyridines at the boron or the zinc ...
TY - JOUR. T1 - Detection of unusual ΔHOMO , ΔLUMO relationship in tetrapyrrolic cis- and trans-doubly N-confused porphyrins. AU - Muranaka, Atsuya. AU - Homma, Shigetsugu. AU - Maeda, Hiromitsu. AU - Furuta, Hiroyuki. AU - Kobayashi, Nagao. PY - 2008/7/30. Y1 - 2008/7/30. N2 - A plus-to-minus MCD sign in ascending energy has been detected for the Q bands of the copper(III) complexes of doubly N-confused porphyrin (cis- and trans-1). An unusual ΔHOMO , ΔLUMO relationship for tetrapyrrolic porphyrins was calculated using the HF, DFT, and semi-empirical methods. By applying the Michls perimeter model, the observed MCD pattern was successfully explained by the computational results.. AB - A plus-to-minus MCD sign in ascending energy has been detected for the Q bands of the copper(III) complexes of doubly N-confused porphyrin (cis- and trans-1). An unusual ΔHOMO , ΔLUMO relationship for tetrapyrrolic porphyrins was calculated using the HF, DFT, and semi-empirical methods. By applying the ...
Description of disease Porphyrins - blood. Treatment Porphyrins - blood. Symptoms and causes Porphyrins - blood Prophylaxis Porphyrins - blood
Abstract: : Purpose:To evaluate the effects of Verteporfin PDT on retinal function in the normal rat. Methods:Brown Norway rats weighing 250-300 grams were used. Animals were anesthetized with 12 mg /100 g tribromoethanol ip for each procedure. Verteporfin PDT: A bolus injection of verteporfin was administered into a cannulated femoral vein at 0.2 mg/kg (equivalent to the clinical dose by body weight). Five minutes following dye administration, the right eye was irradiated with a 689 nm diode laser at 50 J/cm2, 600 mW/cm2 and a spot size of 4 mm (at the cornea) centered on the optic nerve head. ERG: Rats were dark-adapted for 15 minutes, connected to bilateral cornea electrodes and stimulated using a LKC Ganzfeld electrophysiology system, and followed-up (FU) at 4 hours, and Days 1, 2 and 5 post-PDT. OCT: Horizontal scans were made across the optic nerve and retinal thickness measurements were assessed on either side of the nerve head and averaged using a Zeiss Humphrey OCT II system; FU was at ...
TY - JOUR. T1 - Electron Transfer in Ruthenium/Zinc Porphyrin Derivatives of Recombinant Human Myoglobins. Analysis of Tunneling Pathways in Myoglobin and Cytochrome c. AU - Casimiro, Danilo R.. AU - Wong, Luet L.. AU - Colón, Jorge L.. AU - Zewert, Thomas E.. AU - Richards, John H.. AU - Chang, I. Jy. AU - Winkler, Jay R.. AU - Gray, Harry B.. PY - 1993/2/1. Y1 - 1993/2/1. N2 - Site-directed mutants of human myoglobin have been prepared and characterized; each protein has a single surface-modifiable histidine (at position 48, 70, or 83). The proteins were modified by covalent attachment of pentaammineruthenium (a5Ru) to the surface histidine and substitution of zinc mesoporphyrin IX diacid (ZnP) for the heme. Donor-acceptor separations (edge-edge distances d) in the modified proteins are 9.5 Å, His70; 12.7 Å, His48; and 15.5 Å, His83. Rates of photoinduced electron transfer in these ruthenium-modified myoglobins were measured by transient absorption spectroscopy. The 3ZnP*→ Ru3+ rate ...
The electrochemical behavior of meso-tetrakis(4-sulfonatophenyl) porphyrin tetrasodium salt (TPPS4) was investigated in aqueous media of BR buffer in pH range 2-12. Modern electroanalytical methods, i.e DC tast polarography (DCTP) and differential pulse polarography (both at a dropping mercury electrode), differential pulse voltammetry, adsorptive stripping voltammetry, and cyclic voltammetry (all at a hanging mercury drop electrode) were used for this purpose. TPPS4 gives three cathodic signals for pH 2 - 12, first of them corresponding to a two electron quasireversible process. From these signals, the first two are suitable for the determination of TPPS4 using both polarographic methods with limit of determination about 2·10-6 mol L-1 in BR buffer, pH 10. At concentration higher than 3·10-6 mol L-1, the calibration curve of the first signal deviates from the linear course due to formation of aggregates of TPPS4 in solution. The lowest limit of determination, 5.1·10-7 mol L-1 was achieved by AdSV
Ismail, Matthew Arif (1998) DNA-ligand interactions : a biophysical study of 9-hydroxyellipticine, Hoechst 33258 and a meso-substituted porphyrin derivative binding to DNA. PhD thesis, University of Warwick. ...
The deactivation pathways of the singlet excited state of a series of zinc or free-base donor porphyrins covalently linked by a bridge to a paramagnetic iron(III) chloride porphyrin acceptor have been studied. These donor-bridge-acceptor systems all share a similar geometry (25 A donor-acceptor center-to-center distance), but the bridges vary in electronic structure. In previously reported investigations of zinc/iron porphyrin systems, the fluorescence quenching of the donor has predominantly been assigned to electron transfer. However, for the porphyrin systems studied in this paper, we show that the dominant deactivation channels are enhanced intersystem crossing and singlet energy transfer. In both series, the intersystem crossing rate (S1--,T1) of the donor moiety is almost doubled in the presence of a paramagnetic high-spin metal-porphyrin acceptor. The significant spectral overlap of the donor fluorescence and acceptor absorption in both series allows for efficient singlet energy transfer ...
An increase in naturally-occurring porphyrins has been described in the blood of subjects bearing different kinds of tumors, including colorectal, and this is probably related to a systemic alteration of heme metabolism induced by tumor cells. The aim of our study was to develop an artificial neural network (ANN) classifier for early detection of colorectal adenocarcinoma based on plasma porphyrin accumulation and risk factors. We measured the endogenous fluorescence of blood plasma in 100 colorectal adenocarcinoma patients and 112 controls using a conventional spectrofluorometer. Height, weight, personal and family medical history, use of alcohol, red meat, vegetables and tobacco were all recorded. An ANN model was built up from demographic data and from the integral of the fluorescence emission peak in the range 610-650 nm. We used the Receiver Operating Characteristic (ROC) curve to assess performance in distinguishing colorectal adenocarcinoma patients and controls. A liquid chromatography-high
TY - JOUR. T1 - Vibronic coupling between Soret and higher energy excited states in iron(II) porphyrins. T2 - Raman excitation profiles of A2g modes in the Soret region. AU - Egawa, Tsuyoshi. AU - Suzuki, Noriyuki. AU - Dokoh, Takashi. AU - Higuchi, Tsunehiko. AU - Shimada, Hideo. AU - Kitagawa, Teizo. AU - Ishimura, Yuzuru. PY - 2004/1/29. Y1 - 2004/1/29. N2 - Resonance Raman spectra were observed for heme proteins and iron(II) porphyrins including ferrous-CO and ferrous-isocyanide derivatives of cytochrome P450cam, a synthetic iron(II) porphyrin complex having a thiolate axial ligand, ferrous-isocyanide derivative of myoglobin, and synthetic iron(II) porphyrin complexes having either an imidazole or a sulfide axial ligand. Among them, the former three were found to be a hyperporphyrin, giving red and blue Soret absorption bands, whereas others were normal porphyrins giving a single Soret band. When Raman scattering was excited within the Soret region, an anomalously polarized (ap) Raman line, ...
The biochemistry of the porphyrins and of the bile pigments are closely related topics. Heme is synthesized from porphyrins and iron, and the products of degradation of heme are the bile pigments and iron. The biochemistry of the porphyrins and of heme is basic to understanding the varied functions of hemoproteins, and the porphyrias, a group of diseases caused by abnormalities in the pathway of porphyrin biosynthesis. A much more common clinical condition is jaundice, a consequence of an elevated level of plasma bilirubin, due either to overproduction of bilirubin or to failure of its excretion. Jaundice occurs in numerous diseases ranging from hemolytic anemias to viral hepatitis and to cancer of the pancreas. ...
TY - JOUR. T1 - Synthetic Porphyrins/Metalloporphyrins Which Mimic States in Catalytic Cycle of Cytochrome P-450 and Peroxidases. AU - DAEID, N N AU - ATKINSON, S T AU - NOLAN, K B PY - 1993/7. Y1 - 1993/7. N2 - The reaction of thiolates, RS-, having electron withdrawing groups with iron(III) tetra-arylporphyrins in DMSO,in air gives low-spin Fe(III)-P(-SR)2, having hyperporphyrin spectra similar to thiolate derivatives of cytochrome P-450. Removal of air gives high spin Fe(II)-P(-SR) which on addition of CO results in H+ uptake and formation of Fe(II)-P(SHR)CO. Addition of thiols and base to the iron(III) porphyrins in toluene in the absence of air gives 4-coordinate Fe(II)-P which in the presence of CO gives Fe(II)-P(SHR)CO. Metal complexes of one of the porphyrins studied i.e. a tetraphenolic porphyrin undergo 2e- oxidation in air to give quinonoid species which oxidise peroxidase substrates. Rate constants for some of these reactions are reported.. AB - The reaction of thiolates, RS-, having ...
TY - JOUR. T1 - Synthesis and characterization of halogeno- and pseudo-halogeno-thallium(III) porphyrin complexes. Variation of the co-ordination geometry as a function of the axial ligand. AU - Senge, Mathias O.. AU - Ruhlandt, Karin. AU - Regli, Kevin J.. AU - Smith, Kevin M.. PY - 1993. Y1 - 1993. N2 - Several thallium(III) porphyrin complexes [Tl(por)X] with the axial ligand X = MeCO2, CF3CO2, Cl, Br, I, CN, SCN or N3, have been obtained via ligand-exchange reactions from the corresponding thallium(III) trifluoroacetates. All compounds were characterized by 1H NMR, UV/VIS spectroscopy, and elemental analysis. Fourteen compounds were investigated in detail by X-ray crystallography to obtain information on the influence of the axial ligand on the macrocycle core conformation in main-group metalloporphyrins and to establish the molecular stereochemistry of thallium(III) porphyrins with cyano, acetato, thiocyanato, bromo, iodo and azido groups as axial ligands.. AB - Several thallium(III) ...
The work presented in this thesis encompasses an investigation into a number of porphyrin species. All of this work has a central focus on analysis of the porphyrin electronic structure and within the context of photovoltaics. The first exemplar of structures encompasses a series of Zn(II) tetraphenyl porphyrins which have asymmetrically substituted meso groups. The dihedral angle between the porphyrin macrocycle and the meso binding functionality has been shown not to infer any insulating properties towards delocalisation of the excited state. It is proposed that the electron withdrawing ability of the carboxylate unit is more than sufficient to overcome the poor π-overlap between the aromatic units. The inclusion of redox active functionalities at the distal meso site is shown to affect the energy and nature of the oxidised porphyrin species. It does so without almost any effect to the excited state properties of the structure. Both of these findings are important within the context of ...
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TY - JOUR. T1 - Strong π-π Interaction of porphyrins on (6,5) carbon nanotubes with full surface coverage. T2 - Ab-initio calculations. AU - Orellana, Walter. PY - 2014. Y1 - 2014. N2 - The stability, electronic, and optical properties of (6,5) single-walled carbon nanotubes (CNTs) functionalized with free-base tetraphenylporphyrin (TPP) molecules through π-stacking interactions are studied by ab-initio calculations. The stability and optical response of the CNT-TPP compounds for increasing CNT-surface coverage are investigated. Our results show that four TPP molecules forming a ring around the CNT is the most stable configuration, showing strong binding energies of about 2.5 eV/TPP. However, this binding energy can increase even more after additional molecules assemble side by side along the CNT, favoring the formation of a full single layer of TPP, as experimentally suggested. The strong π-π attractive forces induce molecular distortions that move the TPP higher-occupied molecular orbital ...
TY - JOUR. T1 - Complete Double Epoxidation of Divinylbenzene Using Mn(porphyrin)-Based Porous Organic Polymers. AU - Zhang, Kainan. AU - Farha, Omar K.. AU - Hupp, Joseph T.. AU - Nguyen, Son Binh T.. PY - 2015/8/7. Y1 - 2015/8/7. N2 - A series of porphyrin-based porous organic polymers (PPOPs) were synthesized in excellent yields via the Yamamoto-Ullmann couplings of tetrabromo spirobifluorene with several brominated porphyrin monomers. After isolation and demetalation, the metal-free PPOP can be postsynthetically metalated to form a MnIII-PPOP that is catalytically active toward the selective double-epoxidation of divinylbenzene to divinylbenzene dioxide. (Chemical Equation Presented).. AB - A series of porphyrin-based porous organic polymers (PPOPs) were synthesized in excellent yields via the Yamamoto-Ullmann couplings of tetrabromo spirobifluorene with several brominated porphyrin monomers. After isolation and demetalation, the metal-free PPOP can be postsynthetically metalated to form a ...
The Cover. cDNA microarray analysis of HeLa S3 cells treated with the G-quadruplex-interactive cationic porphyrin TMPyP4. Cells were treated with 100 µm TMPyP4 for 48 h, and mRNA was used to probe a 500-gene array. The expression of a number of oncogenes, including c-FOS, JUN-B, c-MYB, STAT-1, and c-MYC, was decreased specifically by this agent, and not by its positional isomer TMPyP2, which interacts with G-quadruplex DNA very poorly. The c-MYC oncogene is one of the most consistently down-regulated genes in this study and bears a sequence in its promoter that forms a G-quadruplex structure in vitro. For details, see 565 in this issue. ...
Heme is a porphyrin that is coordinated with Fe(II). One of the most important classes of chelating agents in nature are the porphyrins [1]. A porphyrin molecule can coordinate to a metal using the four nitrogen atoms as electron-pair donors. In the body, the iron in the heme is coordinated to the four nitrogen atoms of the porphyrin and also to a nitrogen atom from a histidine residue, one of the amino-acid residues in hemoglobin) of the hemoglobin proteins. The sixth protein, coordination site, around the iron of the heme is occupied by O2 when the hemoglobin is oxygenated. The heme group is nonplanar when it is not bound to oxygen [2]. The iron is pulled out of the plane of the porphyrin, towards the histidine residue to which it is attached. This nonplanar configuration is characteristic of the deoxygenated heme group, and is often referred to as being domed shape [2]. When the Fe heme group binds to an oxygen molecule, the porphyrin ring adopts a planar configuration and hence the Fe lies ...
Definition : Clinical chemistry reagents intended to perform qualitative and/or quantitative chemical analysis of body fluids (typically urine) to measure the total level of porphyrin. Analysis may include a profile of porphyrin components (e.g., uroporphyrin, coproporphyrin). Measurement of the total level of porphyrins is used in the diagnosis and management of one of a group of metabolic disorders, either inherited or acquired, usually known as porphyrias; measurement of the porphyrin-level profile in urine is used to characterize several specific diseases, such as porphyria cutanea tarda, that are associated with the presence of isocoproporphyrin. Some specific porphyrin analyses in whole blood are performed for screening purposes, such as zinc protoporphyrin for iron-deficiency anemia and free erythrocyteporphyrin determination for lead poisoning.. Entry Terms : ZPP (Zinc Protoporphyrin) Determination Reagents , Zinc Protoporphyrin (ZPP) Determination Reagents , Porphyrin Determination ...
TY - JOUR. T1 - Free erythrocyte protoporphyrin as an indicator of the biological effect of lead in adult males - II. Comparison between Free Erythrocyte Protoporphyrin and Other Indicators of Effect. AU - Alessio, L.. AU - Bertazzi, P. A.. AU - Monelli, O.. AU - Foà, V.. PY - 1976/6. Y1 - 1976/6. N2 - In previous research we established that FEP is a suitable and valid test for evaluating the metabolic damage caused by lead absorption. In this study, in the same sample consisting of adult male subjects with PbB levels ranging from 15 to 150 μg/100 ml, we examined the relationship existing between PbB and the other indicators of effect so as to compare their behavior with that of FEP and establish whether there is a field of application where the erythrocyte metabolite is to be preferred. FEP and ALAD displayed a very much better correlation with PbB than the urinary tests (ALAU and CPU). The decrease in ALAD values is already clear at PbB levels which do not cause an elevation of FEP; on the ...
Purified imines of porphyrins, chlorins, bateriochlorins, chlorophylls, bacteriochlorophylls, purpurins, reduced purpurins, verdins, Diels Alder adducts, benzochlorins and metal complexes of the foregoing imines are disclosed. The formulas of the benzochlorinimines and of the benzochlorinimine metal complexes are set forth below: ##STR1## In specific examples, M in the metal complexes is a copper cation that is complexed with two of the nitrogens of the benzochlorinimine R and R are methyl, and R1 through R8 are ethyl.
Water is one of the most important components for our life. Preservation of fresh water is one of the most important issues in sustainable development, which is called water treatment. In water treatment there are two main separated steps, separation and degradation. Many kinds of porous materials including zeolites and porous carbons were used for pollutant separation by adsorption. TiO2 was widely used for photocatalytic degradation of pollutant. Here we report new type of inorganic-organic hybrid porous material, metal-organic framework (MOF), which can adsorb pollutant from water followed by degradation of the pollutant by light irradiation. The MOF comprising porphyrin based ligand has good stability in water unlike most of MOFs. The MOF selectively adsorb a pollutant having smaller size than its pore size, which demonstrates size selective pollutant adsorption property of the MOF. In addition, porphyrin ligands decompose the adsorbed pollutant by visible light irradiation. Therefore, the ...
TY - JOUR. T1 - Towards molecular scale mechano-electronic devices:. T2 - porphyrin catenanes. AU - Gunter, Maxwell J.. AU - Johnston, Martin R.. PY - 1992. Y1 - 1992. N2 - Using self-assembly strategies, catenanes consisting of zinc and free base porphyrins with hydroquinol-containing polyether straps of different lengths interlinked with a tetracationic bipyridinium cyclophane have been synthesised.. AB - Using self-assembly strategies, catenanes consisting of zinc and free base porphyrins with hydroquinol-containing polyether straps of different lengths interlinked with a tetracationic bipyridinium cyclophane have been synthesised.. UR - http://www.scopus.com/inward/record.url?scp=37049082995&partnerID=8YFLogxK. U2 - 10.1039/C39920001163. DO - 10.1039/C39920001163. M3 - Article. AN - SCOPUS:37049082995. SP - 1163. EP - 1165. JO - Journal of the Chemical Society, Chemical Communications. JF - Journal of the Chemical Society, Chemical Communications. SN - 0022-4936. IS - 17. ER - ...
According to Greg Hillebrand, Ph.D., a recognized subject matter expert at P&G on the subject, there may be a real correlation between the amount of porphyrins and skin aging as described in the following technical excerpt that offers the best understanding we have today on the matter: In pilosebaceous follicles, porphyrins are produced by propionibacterium acnes (P. acnes) that are normal inhabitants of the human skin and the pilosebaceous ducts. Porphyrins are highly fluorescent pores containing P. acnes and the associated porphyrins appear red-orange when facial skin is illuminated with long wavelength UVA radiation. The intensity of the follicular fluorescence and its extent of facial involvement is known to be proportional to the density of P. acnes. Porphyrin fluorescence appears first on the nose and chin, and then increases in incidence through adulthood and declines after the age of 50, possibly reflecting the rate of sebum secretion. Porphyrins may also have cytotoxic and comedogenic ...
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TY - JOUR. T1 - Synthesis and aggregate formation of triphenylene core-centered porphyrin hexamers. AU - Hasobe, Taku. AU - Rabbani, Mohammad Gulam. AU - Sandanayaka, Atula S.D.. AU - Sakai, Hayato. AU - Murakami, Tatsuya. PY - 2010. Y1 - 2010. N2 - We demonstrate the synthesis, aggregate formation and spectroscopic property of new triphenylene core-centered porphyrin hexamers with different alkyl chain lengths.. AB - We demonstrate the synthesis, aggregate formation and spectroscopic property of new triphenylene core-centered porphyrin hexamers with different alkyl chain lengths.. UR - http://www.scopus.com/inward/record.url?scp=75649142119&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=75649142119&partnerID=8YFLogxK. U2 - 10.1039/b915983e. DO - 10.1039/b915983e. M3 - Article. C2 - 20107640. AN - SCOPUS:75649142119. VL - 46. SP - 889. EP - 891. JO - Chemical Communications. JF - Chemical Communications. SN - 1359-7345. IS - 6. ER - ...
Seeing that interaction with projections on any surface could be a powerful technology, in 1998 they had turned the GestureXtreme system on its head to invent the Worlds First Interactive Projected Surfaces. The GestureFX, (GestureFX) Japanese Annual IEEE International Symposium on Personal, Indoor and Mobile Radio Communications, Helsinki, Finland, 1-5. Quality written sensitive ET of ideal Outsourcing Definitions. 2006 IEEE International Conference on Communications 4:1754-1759. OM fiction for clicking % shared browser in a free ad hoc cue. decision of cavity home in a sent 19th product number. IEEE Global Telecommunications Conference( Globecom06), San Francisco, CA. free active marketplace: A interpretation for Enhancing in competitive position. Digital Humanities 2006, Paris, France, 309. tourist products for Looking and including books for other scrutiny back. Digital Humanities 2006, Paris, France, 107. A gibt collection item and JPEG gripping minutes loading level. open formation on ...
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The porphyrias are a group of rare inherited or acquired disorders that result from a buildup of natural chemicals that produce porphyrin in your body. Porphyrins are essential for the function of hemoglobin - a protein in your red blood cells that links to porphyrin, binds iron, and carries oxygen to your organs and tissue. High levels of porphyrins can cause significant problems. 20. Porphyria mainly affects your nervous system, skin and other organs.. ...
The porphyrias are a group of rare inherited or acquired disorders that result from a buildup of natural chemicals that produce porphyrin in your body. Porphyrins are essential for the function of hemoglobin - a protein in your red blood cells that links to porphyrin, binds iron, and carries oxygen to your organs and tissue. High levels of porphyrins can cause significant problems. 20. Porphyria mainly affects your nervous system, skin and other organs.. ...
In patients with porphyria, high levels of porphyrins may circulate in the blood and are deposited in the skin. Porphyrins are photoactive molecules, the property responsible for their fluorescence. When a light ray (particularly one with a wavelength in the ultraviolet range) strikes a porphyrin molecule, the energy of the light is absorbed by the molecule, and some of its electrons become more active (technically we say that they are promoted to a higher energy level). In due course, the molecule relaxes by allowing the promoted electrons to drop back to a normal energy level. To do so, they must give out the extra energy they contain. This is radiated out as heat and light. If this takes place in the skin, it causes damage. It is for this reason that the skin disease of porphyria is usually restricted to areas which are exposed to the sun, and that avoiding sun exposure is so important in preventing skin disease.. ...
Participants received Verteporfin photodynamic therapy and 1 mg triamcinolone acetonide intravitreal injection at the baseline visit. After the baseline visit, these participants received Verteporfin and triamcinolone acetonide 1 mg at every 3 month visit up to Month 9 only if leakage was detected on the fluorescein angiogram. At the 1.5, 4.5, 7.5 and 10.5 month follow-up visits participants received a sham injection. Starting from Month 12, if patients experienced ≥ 10 letters vision loss from the previous visit, they were treated at the investigators discretion with available standard of care therapy ...
I got back a Urinary Porphyrins test from the Laboratoire de Biologie Medicale in Paris France. The following things have been flaged. Uroporphyrins I &am...
OUTLINE: This is a dose-escalation study. Patients are stratified according to tumor location (posterior fossa tumors vs all other brain tumors).. Patients receive benzoporphyrin monoacid ring A (BPD-MA) IV preoperatively. Approximately 3 hours after BPD-MA administration, patients undergo craniotomy with photoillumination of the tumor. Patients with tumors greater than 2 cm in diameter also undergo gross tumor resection.. Cohorts of 3-6 patients receive escalating doses of BPD-MA until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose immediately preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. Three additional patients are treated at the MTD.. Patients are followed at 4 and 6 weeks, every 3 months for 1 year, every 6 months for 1 year, and then annually thereafter.. PROJECTED ACCRUAL: A minimum of 24 patients will be accrued for this study within 3 years. ...
Optical limiting properties in CH2Cl2 solution of a series of axially substituted InTPP (indium tetraphenyl-porphyrin) and axially substituted InTTP (indium tetra-p-tolyl-porphyrin) are investigated using a 532 nm laser with a pulse duration of 5 ns. The axial substitutions include -Cl, -SCN, -SPh and -SPh(p-Me). The optical limiting measurements reveal that the optical limiting properties of the indium porphyrins are greatly influenced by the axially attached functional groups. A limiting threshold of 0.18 J/cm2 is achieved for TTPInSCN, which is the best optical limiting material in this report. Z-scan experiments are also conducted and confirm that the good optical limiting performance of these indium porphyrins is due to the large value of σex/σg ...
Sonodynamic therapy, the ultrasound dependent enhancement of cytotoxic activities of certain compounds (sonosensitizers) in studies with cells in vitro and in tumor bearing animals, is reviewed. The attractive features of this modality for cancer treatment emerges from the ability to focus the ultrasound energy on malignancy sites buried deep in tissues and to locally activate a preloaded sonosensitizer. Possible mechanisms of sonodynamic therapy include generation of sonosensitizer derived radicals which initiate chain peroxidation of membrane lipids via peroxyl and/or alkoxyl radicals, the physical destabilization of the cell membrane by the sonosensitizer thereby rendering the cell more susceptible to shear forces or ultrasound enhanced drug transport across the cell membrane (sonoporation). Evidence against the role of singlet oxygen in sonodynamic therapy is discussed. The mechanism of sonodynamic therapy is probably not governed by a universal mechanism, but may be influenced by multiple factors
which are well-known because of their notable functional properties (for instance,. Many previous researchers focus on wet-chemical methods for attaching the molecules to the surface of the material. The TUM team, however, decided to take a different approach: The researchers were able to link porphyrin molecules to graphene in a controlled manner in an ultra-high vacuum using the catalytic properties of a silver surface on which the graphene layer rested. When heated, the porphyrin molecules lose hydrogen atoms at their periphery and can thus form new bonds with the graphene edges ...
The delocalization of the photoexcited triplet state in a linear butadiyne-linked porphyrin dimer is investigated by time-resolved and pulse electron paramagnetic resonance (EPR) with laser excitation. The transient EPR spectra of the photoexcited triplet states of the porphyrin monomer and dimer
A hexafullereno-diporphyrinoid was obtained in a sequence of cycloaddition steps using porphyrins programmed for [4+2]-cycloaddition reactions and C60-fullerene. Porphyrins & Phthalocyanines
A one-pot synthesis of bulky bis-pocket A3B-type meso-cyano porphyrin, 5-cyano-10,15,20-tris(2,4,6-triphenylphenyl)porphyrin, has been accomplished via trifluoroacetic acid (TFA) catalyzed condensation of pyrrole and 2,4,6-triphenylbenzaldehyde in an acceptable yield of about 4%. DDQ served as oxidant and the cyanating agent.
The design of new photosensitizers (PS) with improved properties is essential for the development of photodynamic therapy as an alternative therapeutic method. The conjugation of porphyrins, well known PS, with platinum(ii) complexes, potent anticancer agents, may achieve new compounds with synergistic treat
Chlorophyll, blood, and vitamin B12 are all based on the porphyrin molecule. But porphyrin can also be used as an electrode material where it speeds up the charging process of rechargeable batteries. In the Angewandte Chemie International Edition journal, researchers from KIT now present the new material system that could mark the beginning of an era of high-performance energy storage and supercapacitors. Currently, the most widely used battery technology is based on lithium ions. No other rechargeable storage device for electric energy has comparable application properties. Thus, lithium ion batteries are currently indispensable for devices such as laptops, smartphones, or cameras, even though improved properties such as quick-charging would be desirable. Many materials that improve the properties of lithium ion batteries in the lab, however, are no sustainable options because they are rare, expensive, toxic or harmful to the environment. Ideally, high-performance energy storage materials ...
Nowadays, novel less-expensive nanoformulations for in situ-controlled and safe delivery of photosensitisers (PSs) against opportunistic pathogens in body-infections areas need to be developed. Antimicrobial photodynamic therapy (aPDT) is a promising approach to treat bacterial infections that are recalcitrant to antibiotics. In this paper, we propose the design and characterization of a novel nanophototherapeutic based on the trade cyclodextrin CAPTISOL® (sulfobutylether-beta-cyclodextrin, SBE-βCD) and 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphine tetrakis(p-toluenesulfonate) (TMPyP) to fabricate efficient biocompatible systems for aPDT. Spherical nanoassemblies of about 360 nm based on CAPTISOL®/TMPyP supramolecular complexes with 1:1 stoichiometry and apparent equilibrium binding constant (Kb ≅ 1.32 × 105 M−1) were prepared with entrapment efficiency of ≅ 100% by simple mixing in aqueous media and freeze-drying. These systems have been characterized by complementary ...
A series of tetraphenylporphyrins appended at the β-pyrrolic position with an ethynylphenylene- or ethynylpyridine-substituent have been subjected to spectroscopic and density functional theory (DFT) analyses. The mean absolute deviation between corresponding experimental and DFT-derived vibrational spectra is up to 10.2 cm -1, suggesting that the DFT B3LYP/6-31G(d) method provides an accurate model of the β-substituted porphyrin systems. The configuration interactions that give rise to prominent electronic absorptions have been calculated using time-dependant DFT (TD-DFT) and have been rationalized with reference to the energy and topology of DFT calculated molecular orbitals. As the electron withdrawing capacity of the β-substituent increases the LUMO orbital gains appreciable amplitude over the substituent moiety and is stabilised. This represents a departure from the assumptions underpinning the Gouterman four-orbital model, resulting in atypical electronic absorption spectra. This ...
Iron porphyrins with the intermediate spin S = 3/2 or admixed with S = 5/2 or 1/2 are models for a number of heme protein systems, including cytochromes c. The (57)Fe Mossbauer quadrupole splittings and (1)H and (13)C NMR chemical shifts have been found to be useful probes of their electronic states. We present the results of the first successful quantum chemical calculations of the Mossbauer and NMR properties in various S = 3/2 iron porphyrin complexes, covering four-, five-, and six-coordinate states and three commonly seen porphyrin conformations: planar, ruffled, and saddled. Several interesting correlations among these useful experimental spectroscopic probes and geometric and electronic properties were discovered. These results should facilitate future investigations of related heme proteins and model systems.
Porphyrins[edit]. Porphyrins are a group of naturally occurring and intensely coloured compounds, whose name is drawn from the ... Expanded metallo-porphyrins[edit]. Expanded porphyrins have a larger central binding cavity, increasing the range of potential ... In porphyrin systems, the zinc ion (Zn2+) appears to hinder the photodynamic activity of the compound. By contrast, in the ... Texaphyrins are expanded porphyrins that have a penta-aza core. It offers strong absorption in the 730-770 nm region. Tissue ...
... is an organic compound, which is one of the most common porphyrins in nature. It is a deeply colored pigment ... The free porphyrin is encountered in nature in the form of its iron complexes. When complexed with ferrous iron, the molecule ... F. J. Leeper (1983). "The biosynthesis of porphyrins, chlorophylls, and vitamin B12". Natural Product Reports. 2: 19-47. doi: ... Winslow S. Caughey, James A. Ibers (1977). "Crystal and Molecular Structure of the Free Base Porphyrin, Protoporphyrin IX ...
Porphyrins. Protoporphyrins. *Protoporphyrin IX. *Heme (b, c, a, o). *Zinc protoporphyrin. *Magnesium protoporphyrin ...
The following carbon numbering system of porphyrins is an older numbering used by biochemists and not the 1-24 numbering system ... Structure of Fe-porphyrin subunit of heme A.[11] Heme A is synthesized from heme B. In two sequential reactions a 17- ... Heme or haem is a coordination complex "consisting of an iron ion coordinated to a porphyrin acting as a tetradentate ligand, ... In peroxidase reactions, the porphyrin molecule also serves as an electron source. In the transportation or detection of ...
... "expanded porphyrin"". J. Am. Chem. 112: 2810. doi:10.1021/ja00163a059. Juwarker, H.; Jeong, K-S. (2010). "Anion-controlled ...
A heme group consists of an iron (Fe) ion (charged atom) held in a heterocyclic ring, known as a porphyrin. This porphyrin ring ... The color is actually due to the porphyrin moiety of hemoglobin to which the iron is bound, not the iron itself,[105] although ... Brown manganese-based porphyrin protein.. Leghemoglobin. In leguminous plants, such as alfalfa or soybeans, the nitrogen fixing ... When oxygen binds to the iron complex, it causes the iron atom to move back toward the center of the plane of the porphyrin ...
Thunell, S (2000). "Porphyrins, porphyrin metabolism and porphyrias. I. Update". Scandinavian Journal of Clinical and ... In the absence of iron, which is to be incorporated in the porphyrin formed in the last step of the synthesis, the mRNA of ... Held, H. (2009). "Effect of Alcohol on the Heme and Porphyrin Synthesis Interaction with Phenobarbital and Pyrazole". Digestion ... Miller, Dennis M.; Woods, James S. (1993). "Urinary porphyrins as biological indicators of oxidative stress in the kidney". ...
Regulation of guanylate cyclase activity by porphyrins and metalloporphyrins. J. Biol. Chem. 259: 6201-6207. ...
The excretion of porphyrins produce purple-red pigments in teeth.[29]. *Hemolytic disease of the newborn:[9] This disease ... metabolic disorder where the body struggles to metabolise porphyria which leads to accumulation or the excretion of porphyrins ...
... which leads to accumulation or excretion of porphyrins into teeth. The excretion of porphyrins produces purple-red pigments in ... Porphyria:[9] A rare metabolic disorder in which the body fails to adequately metabolise porphyrins, ...
Example: hemoglobin contains heme, a porphyrin complex of iron. Example: chlorophyll contains a porphyrin complex of magnesium ...
Boronated porphyrins. Transferrin-polyethylene glycol liposomes Boronated sugars. aThe delivery agents are not listed in any ...
For example, porphyrins-associated with some skin diseases-will fluoresce pink. Though the technique for producing a source of ...
Porphyrins additionally accumulate in the bone and teeth, resulting in erythrodontia.[10][11] When unexpected attacks occur, ... In Gunther's disease, porphyrins are accumulated in the teeth and bones and an increased amount are seen in the plasma, bone ... These bulbs release less light, which prevents the "porphyrin-exciting" wavelengths that fluorescent lights emit.[16] Other ... "Porphyrins in urine, plasma, erythrocytes, bile and faeces in a case of congenital erythropoietic porphyria (Gunther's disease ...
"Hemoglobin-derived porphyrins preserved in a Middle Eocene blood-engorged mosquito". Proceedings of the National Academy of ...
A well known example is the picket fence porphyrin, which consists of a ferrous complex of a sterically bulky derivative of ... A picket-fence porphyrin complex of Fe, with axial coordination sites occupied by methylimidazole (green) and dioxygen. The R ... Myoglobin contains a porphyrin ring with an iron at its center. A proximal histidine group (His-93) is attached directly to ... In nature, such deactivation pathways are suppressed by protein matrix that prevents close approach of the Fe-porphyrin ...
Folk, Shawn P.; Leung, K.-P. (2002-03-01). "Effects of porphyrins and inorganic iron on the growth of Prevotella intermedia". ...
The reddish colour is derived from porphyrins and is thought to provide the young birds some camouflage.[8] Once breeding is ... "Porphyrins and pheomelanins contribute to the reddish juvenal plumage of black-shouldered kites". Comparative Biochemistry and ...
... porphyrin-copper(II) complex". J. Am. Chem. Soc. 102 (4): 1470-1473. doi:10.1021/ja00524a066.. ...
"Synthesis and properties of a meso- tris-ferrocene appended zinc(II) porphyrin and a critical evaluation of its dye sensitised ... "The ferrocene effect: enhanced electrocatalytic hydrogen production using meso-tetraferrocenyl porphyrin palladium(II) and ...
... porphyrins: Synthesis, Structure, and Optical Properties". J. Org. Chem. 77 (24): 11119-11131. doi:10.1021/jo302135q.. ...
It's thought that the pi-cation porphyrin radical undergoes reactivity at the methine bridges connecting the four rings. ...
Fecal porphyrin quantification by HemoQuant can yield a false positive result due to exogenous blood and various porphyrins. ... These look at different properties, such as antibodies, heme, globin, or porphyrins in blood, or at DNA from cellular material ...
Abelsonite (nickel porphyrin) is a mineral that can be pinkish-brown, purple, or reddish-brown in colour and is formed from ... Porphyrins are organic ring compounds like haeme, the pigment in red blood cells. ... porphyrin crystals. It is platy (made in plates like mica) and fragile. ...
Homozygous acute intermittent porphyria in a 7-year-old boy with massive excretions of porphyrins and porphyrin precursors., in ...
Nitrogen and carbon isotopic evidence from sedimentary porphyrin". Organic Geochemistry. 39 (5): 532-549. doi:10.1016/j. ...
"Assembly and Crystal Structure of a Photoactive Array of Five Porphyrins". Angew. Chem., Int. Ed. Engl. 34 (10): 1096-1099. DOI ...
Examples include eosin Y and rose bengal.[9] Pyrrole rings such as porphyrins have also been used in coating nanomaterials or ... but also porphyrin-derived ones) were prepared during the early 2000s.[9] Both types of assembly are under development to ... including the addition of ferrocene and pyrrole-like molecules such as porphyrins and phthalocyanines.[6] ...
An example of this would be the synthesis of porphyrins in refluxing propionic acid. By cooling the reaction mixture to room ... temperature, crystals of the porphyrin precipitate, and are collected by filtration:[2] ...
Diagnosis is by finding raised urine porphyrins, raised faecal porphyrins, markedly raised plasma porphyrins (pathognomic) and ...
Porphyrins are natural chemicals in the body that help form many important substances in the body. One of these is hemoglobin, ... Normal results vary depending on the type of porphyrin tested. In general, for a 24-hour urine test of total porphyrins, the ... Porphyrins are natural chemicals in the body that help form many important substances in the body. One of these is hemoglobin, ... Your provider will order this test if you have signs of porphyria or other disorders that can cause abnormal urine porphyrins. ...
Porphyrins help form many important substances in the body. One of these is hemoglobin. This is the protein in red blood cells ... Porphyrins help form many important substances in the body. One of these is hemoglobin. This is the protein in red blood cells ... Porphyrins, quantitative - blood. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St ... Porphyrins can be measured in the blood or the urine. This article discusses the blood test. ...
... porphyrin) and of a "picket fence" porphyrin derivative with an appended axial base have been measured in solution and compared ... Carbon monoxide binding to iron porphyrins. J P Collman, J I Brauman, and K M Doxsee ... The carbon monoxide affinities of iron complexes of meso-tetra (alpha, alpha, alpha, alpha-o-pivalamidophenyl)porphyrin (the " ...
Porphyrins are natural chemicals in the body that help form many important substances in the body. One of these is hemoglobin. ... Normal results vary depending on the type of porphyrin tested. In general, for a 24-hour urine test of total porphyrins, the ... Porphyrins are natural chemicals in the body that help form many important substances in the body. One of these is hemoglobin, ... Porphyrins can be measured in the urine or blood. . This article discusses the urine test. ...
Porphyrins are chemicals in your body. When they build up to high levels, they can be a sign that somethings wrong. Heres ... Testing porphyrins to diagnose porphyria. Porphyrins are natural chemicals that are found in your body. They are an important ... One type of porphyrin urine testing is with a random, single urine sample, or they may ask you to complete a urine test over a ... Doctors may use porphyrin urine testing as part of their diagnosis of the following types of neurologic porphyrias:. *acute ...
Here, we present two molecular motor-functionalized porphyrin macrocycles for future photo-switchable catalysis. They display ... Here, the authors present two molecular motor-functionalized porphyrin macrocycles for future photo-switchable catalysis. ... Free base porphyrin macrocycle H21, zinc(II) porphyrin macrocycle Zn1, manganese(III) porphyrin macrocycle Mn1, nickel(II) ... Porphyrin macrocycles, such as H21 and Zn1, are known for their ability to strongly bind viologen guests (Fig. 2b)27,28,29,30, ...
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... infrared data and UV-visible spectral data of porphyrin derivative C80H58F4N4O12. ... Gupta R. (2016) Spectral data of porphyrin derivative C80H58F4N4O12. In: Gupta V., Lechner M.D., Gupta R. (eds) Porphyrins. ... Spectral data of porphyrin derivative C80H58F4N4O12. ... infrared data and UV-visible spectral data of porphyrin ...
This chapter contains a tabular compilation of nuclear magnetic resonance data and UV-visible spectral data of porphyrin ... Gupta R. (2016) Spectral data of porphyrin derivative C80H70N4O8. In: Gupta V., Lechner M.D., Gupta R. (eds) Porphyrins. ... This chapter contains a tabular compilation of nuclear magnetic resonance data and UV-visible spectral data of porphyrin ... Spectral data of porphyrin derivative C80H70N4O8. ...
... has been selected to receive the 2010 Hans Fischer Career Award in Porphyrin Chemistry by the Society of Porphyrins and ... has been selected to receive the 2010 Hans Fischer Career Award in Porphyrin Chemistry by the Society of Porphyrins and ... The Society of Porphyrins and Phthalocyanines was formed in June 2000 and serves the interests of scientists working in those ... The award is given every two years to a senior scientist for his or her lifetime work in the field of porphyrins and ...
... Donato Monti,1 Sara Nardis,1 Manuela Stefanelli,1 Roberto Paolesse,1 ... Within this wide scenario, tailored solid films of porphyrin derivatives are structures of great potential for, among others, ... This allows, for example, the formation of large well-defined porphyrin aggregates in solution that can be spontaneously ... Moreover, the variation of peripheral substituents of porphyrins, such as, for example, chiral appended functionalities, can ...
The indicated porphyrins showed major fluorescence excitation at 390 nanometers. Abundance was about 10-10 gram of porphyrin ... Search for Porphyrins in Lunar Dust. By Gordon W. Hodgson, Etta Peterson, Keith A. Kvenvolden, Edward Bunnenberg, B. Halpern, C ... Search for Porphyrins in Lunar Dust. By Gordon W. Hodgson, Etta Peterson, Keith A. Kvenvolden, Edward Bunnenberg, B. Halpern, C ... Evidence for porphyrins was obtained in the Apollo 11 bulk sample of lunar dust by fluorescence spectrometry and analytical ...
Expanded porphyrins are larger versions of the familiar tetrapyrrole compounds. These extended aromatic frameworks could ... They find that electron- acceptor molecules such as trinitrobenzene (TNB) form 1:1 adducts with the expanded porphyrins, which ...
Peaks that denote specific porphyrins as well as the distinctive porphyrin spectral pattern are absent. (D-F) Enlarged insets ... Porphyrins in a blood-engorged fossil mosquito. Dale E. Greenwalt, Yulia S. Goreva, Sandra M. Siljeström, Tim Rose, Ralph E. ... Porphyrins in a blood-engorged fossil mosquito. Dale E. Greenwalt, Yulia S. Goreva, Sandra M. Siljeström, Tim Rose, Ralph E. ... and arguably hemoglobin-derived porphyrins in a 46-million-year-old compression fossil and localize the porphyrins to a ...
... Misako Okada,1 Yuko Kishibe,1 Kanako Ide,1 ... lactoside-modules onto a porphyrin-core was achieved through -catalyzed chemoselective coupling (click chemistry) between a ... The obtained porphyrin-based glycocluster shows not only good water-solubility but also strong/specific lectin-affinity. ... porphyrin carrying eight alkyne-terminals and -lactosyl azides. ...
Journal of Porphyrins and Phthalocyanines Handbook of Porphyrin Science Porphynet - an informative site about porphyrins and ... The third porphyrin that is [18]porphyrin-(2.1.1.0), was reported by Callot and Vogel-Sessler. Vogel and coworkers reported ... The first synthetic porphyrin isomer was reported by Emanual Vogel and Coworkers in 1986. This isomer [18]porphyrin-(2.0.2.0) ... A porphyrin-related disease: porphyria Porphyrin coordinated to iron: heme A heme-containing group of enzymes: Cytochrome P450 ...
... catabolic derivatives and related systems electronically.The porphyrins are an important class of naturally ... of this volume is to present a full and critical spectral data coverage of the entire major fields relating to porphyrin ... Porphyrins - Spectral Data of Porphyrin Isomers and Expanded Porphyrins. Authors. * M.P. Dobhal ... Porphyrins - Spectral Data of Porphyrin Isomers and Expanded Porphyrins. Authors: Dobhal, M.P. ...
Fluorination via porphyrin. Source: Chemistry World , September 13th, 2012 , By Ian Le Guillou Industry type: Pharmaceuticals ... Now, a manganese porphyrin has been used to selectively fluorinate sp3 carbon-hydrogen bonds using silver fluoride as a source ... The manganese (III) porphyrin complex is oxidised by iodosylbenzene to form an oxomanganese (V) intermediate that selectively ... The resulting carbon-centred radical reacts with a trans-difluoro manganese (IV) porphyrin, forming the C-F bond and ...
We computed adsorbed structures of transition-metal complexes of porphyrin and porphycene on graphene, and evaluated the ... Applicability of Density Functional Tight Binding Method with Dispersion Correction to Investigate the Adsorption of Porphyrin/ ...
Porphyrins blood test. Definition. Porphyrins help form many important substances in the body. One of these is hemoglobin. This ... More tests are needed to show the levels of specific porphyrins.. How to Prepare for the Test. You should not eat for 12 to 14 ... Protoporphyrin levels; Porphyrins - total; Coproporphyrin levels; PROTO test. How the Test is Performed. A blood sample is ... Porphyrins can be measured in the blood or the urine. This article discusses the blood test. ...
PORPHYRINS PROFILE. GENERAL. Porphyrins are generated as the body builds hemoglobin, the compound that carries oxygen in blood ... Small amounts of several porphyrins appear in urine normally. The relative amounts of each porphyrin are altered by certain ... Porphyrin (from the Greek word for purple) is made up of four ring compounds joined together, a structure conducive to holding ... a metal ion in its center, iron in the heme porphyrin of hemoglobin and magnesium in chlorophyll. ...
Efficient Solar Photooxygenation with Supported Porphyrins as Catalysts. Authors. *. Sónia Ribeiro,. *Chemistry Department, ...
Inspired by natural photosynthesis, scientists utilized artificial chlorophylls - the porphyrins - as efficient centres to ... porphyrin. (PSSC). After the first example appeared in 1993 of a porphyrin. of type copper chlorophyll as a photosensitizer for ... porphyrin. sensitizer of this type in 2010. With a structural design involving long alkoxyl chains to envelop the porphyrin ... porphyrin. sensitizers used in PSSC, we review systematically the progress of porphyrins. of varied kinds, and their ...
... present a full and critical spectral data coverage of the entire major fields relating to tetraphenyl and analogous porphyrins ... The porphyrins are an important class of naturally occurring macro cyclic compounds that play a very important role in the ... Without porphyrins and their relative compounds, life as we know it would be impossible and therefore the knowledge of these ... Spectral data of porphyrin derivative C44H18Cl8N4O12K4S4 ... Spectral data of porphyrin derivative C44H22Cl2F8N4O8 ...
The use of Porphyrins as Photosensitizers for the Treatment of Cerebral Glioma ...
The first and second generations of these porphyrin-PAMAM-fluorene dendrimers were characterized by 1H-NMR, 13C-NMR, FTIR, UV- ... This article belongs to the Special Issue Tetrapyrroles, Porphyrins and Phthalocyanines) Full-Text , PDF [1488 KB, uploaded 13 ... The first and second generations of these porphyrin-PAMAM-fluorene dendrimers were characterized by 1H-NMR, 13C-NMR, FTIR, UV- ... "High Fluorescent Porphyrin-PAMAM-Fluorene Dendrimers." Molecules 20, no. 5: 8548-8559. ...
Developments in Supramolecular Chemistry Based on Porphyrins and Related Systems Involvement of Porphyrins and Related Systems ... "The Handbook of Porphyrin Science at World Scientific". Archived from the original on 2010-03-31. Retrieved 2009-08-19. v t e. ... Published by World Scientific, the Handbook of Porphyrin Science: With Applications to Chemistry, Physics, Materials Science, ... Phthalocyanines and Related Systems Heme Proteins The current work stems from World Scientifics Journal of Porphyrins and ...
A circle of 12 zinc-centered porphyrins surrounds six aluminum-centered porphyrins, bridged by Y-shaped ligands. ... A circle of 12 zinc-centered porphyrins surrounds six aluminum-centered porphyrins, bridged by Y-shaped ligands. ... The outer ring, made from 12 zinc-porphyrins, is tethered to the core by six Y-shaped ligands that bind to the zinc and ... But they found that the outer ring could be constructed by mixing chains of four zinc-porphyrins with the Y-shaped ligands and ...
  • Acne treatment: Porphyrins in the body absorbs blue light and makes singlet oxygen which destroys the bacteria creating acne. (eol4health.com)
  • It is thought that blue light, which is part of the visible light spectrum of sunlight, is absorbed by porphyrins produced by acne-causing bacteria. (cloudfront.net)
  • Thanks to our groundbreaking ideas, we have first substituted LED for ultraviolet light to analyze the melanin pigments and Porphyrin (bacteria that cause acne). (psiplus.co.kr)
  • The differentially enriched proteins in leaves were mainly involved in porphyrin and chlorophyll metabolism, phenylpropanoid biosynthesis, starch and sucrose metabolism, and carbon fixation in photosynthetic organisms. (researchsquare.com)
  • Six differentially enriched proteins were mapped onto the porphyrin and chlorophyll metabolism pathway in leaves of the M genotype, including five upregulated proteins involved in chlorophyll biosynthesis and one downregulated protein involved in chlorophyll degradation. (researchsquare.com)
  • Porphyrins and metalloporphyrins in synthetic bilayer membranes. (princeton.edu)
  • Dive into the research topics of 'Porphyrins and metalloporphyrins in synthetic bilayer membranes. (princeton.edu)
  • Based on spectroscopic data, the free base porphyrin exhibits a nonplanar macrocycle in solution with a degree of distortion between that of 5,10,15,20-tetracyclohexyl-porphyrin and 5,10,15,20-tetra(r-butyl)porphyrin. (mpg.de)
  • Chemical methods will be developed to link long-chain aliphatics, anti-inflammatory compounds, carbohydrates, anti-angiogenic, and others, to the porphyrin macrocycle. (polythea.eu)
  • The water disinfectant chlorine dioxide can be generated catalytically by the manganese porphyrin MnTDMImP. (princeton.edu)
  • Our primary photo-acceptors located within the mitochondria are flavins, cytochromes and porphyrins. (lateralmovement.ca)
  • Each individual wavelength has a specific target chromophore within the skin (such as melanin, haemoglobin, water, cytochrome c oxidase, porphyrins etc. (dermaluxled.com)
  • Photocatalysis of natural reactions by polypyridyl complexes, porphyrins or other dyes is extensively used by natural chemists to provide materials inaccessible by classical approaches. (littlelisasmile.com)
  • It is known that cromophores (part of a molecule) in the form of porphyrins play an important role as well, acting as electric absorption bands. (lateralmovement.ca)
  • The pKa value of the proximal water molecule trans to a high-valent MnV=O porphyrin: towards the control of reactivity by pH. (univ-grenoble-alpes.fr)
  • We have employed the scanning tunneling microscope break-junction technique to investigate the single-molecule conductance of a family of 5,15-diaryl porphyrins bearing thioacetyl (SAc) or methylsulfide (SMe) binding groups at the ortho position of the phenyl rings (S2 compounds). (dutch-martialarts.nl)
  • Used as electronic materials intermediates, and synthesis of a N2S2-N4 porphyrin two conjoined blocks, which is used to study light-induced energy transfer. (beilichem.com)
  • The bloodworm has red iron-porphyrin protein in its blood and tissue which gives it its characteristic colour. (diapteron.co.uk)
  • Age can be deduced by shining UV light on wing feathers, which highlights the presence of the protein porphyrin. (birdwatchingdaily.com)
  • Using scanning tunneling microscope break-junction experiments and a new first-principles approach to conductance calculations, we report and explain low-bias charge transport behavior of four types of metal-porphyrin-gold molecular junctions. (dutch-martialarts.nl)
  • PN: The next step would be to investigate naturally occurring pattern formation and understand better the local structural dynamics of organic molecules such as porphyrins as they evolve from a disordered phase to an energetically stable stage and verify their internal response to external electrical pulses. (blogspot.com)
  • It may be considered a tetra- hydro derivative of a corphin [6, 101, combining structural elements of both porphyrins and corrins. (abo-sommerhuse.dk)
  • A narrow or crooked duct then spills the porphyrins along your dog's nose, and exposure to light makes the iron particles show as red or rust-colored stains. (figopetinsurance.com)
  • These porphyrins are the result of normal red-blood-cell breakdown and are typically excreted in the tears, saliva, and urine. (figopetinsurance.com)
  • Morphology control in auto-assembly of Zinc meso-tetra (4-pyridyl) porphyrin (ZnTPyP) - Executive Summary by Hyung Nun (Jonny) Kim and Yongshuai (Eric) Wang Materials Informatics Course. (gatech.edu)
  • A team of chemists, biotechnologists and doctors at the University of Pennsylvania and the University of Minnesota has called porphyrins fluorescent materials in the surface of polymersomes brought a cell - like vesicle, an image of a tumor in a living rodent. (mauicarriage.com)
  • Carrot leaves contain significant amounts of porphyrins, which stimulate the pituitary gland and lead to the release of increased levels of sex hormones. (naturalcompounds.org)
  • Handbook of Porphyrin Science Local access only for NSU and Broward. (nova.edu)
  • Numerous studies of autistic individuals have revealed evidence of cerebral hypoperfusion, neuroinflammation and gastrointestinal inflammation, immune dysregulation, oxidative stress, relative mitochondrial dysfunction, neurotransmitter abnormalities, impaired detoxification of toxins, dysbiosis, and impaired production of porphyrins. (to-treat-autism.com)
  • Impaired production of porphyrins in autistic children might affect the production of heme, and HBOT might help overcome the effects of this problem. (to-treat-autism.com)