A large class of organic compounds having more than one PHENOL group.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
A group of phenyl benzopyrans named for having structures like FLAVONES.
The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.
An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
Fermented juice of fresh grapes or of other fruit or plant products used as a beverage.
Dimers (homo and hetero) of FLAVONOIDS.
Camellia sinensis L. (formerly Thea sinensis) is an evergreen Asiatic shrub of the THEACEAE family. The infusion of leaves of this plant is used as Oriental TEA which contains CAFFEINE; THEOPHYLLINE; and epigallocatechin gallate.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They are structurally similar to ANTHOCYANINS but are the result of a different fork in biosynthetic pathways.
A colorless or slightly yellow crystalline compound obtained from nutgalls. It is used in photography, pharmaceuticals, and as an analytical reagent.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.
A plant genus in the family VITACEAE, order Rhamnales, subclass Rosidae. It is a woody vine cultivated worldwide. It is best known for grapes, the edible fruit and used to make WINE and raisins.
Polymeric derivatives of GALLIC ACID that are esters of a sugar.
Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.
A naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. (From J Chromatogr A 1996;741(2):223-31; Biosci Biotechnol Biochem 1996;60(5):765-68).
Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.
Organic compounds that contain 1,2-diphenylethylene as a functional group.
A group of FLAVONOIDS derived from FLAVONOLS, which lack the ketone oxygen at the 4-position. They are glycosylated versions of cyanidin, pelargonidin or delphinidin. The conjugated bonds result in blue, red, and purple colors in flowers of plants.
A tree of the family Sterculiaceae (or Byttneriaceae), usually Theobroma cacao, or its seeds, which after fermentation and roasting, yield cocoa and chocolate.
A plant genus in the family ROSACEAE, order Rosales, subclass Rosidae. It is best known as a source of the edible fruit (apple) and is cultivated in temperate climates worldwide.
Exudate from seeds of the grape plant Vitis vinifera, composed of oils and secondary plant metabolites (BIOFLAVONOIDS and polyphenols) credited with important medicinal properties.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
Use of plants or herbs to treat diseases or to alleviate pain.
Liquids that are suitable for drinking. (From Merriam Webster Collegiate Dictionary, 10th ed)
The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.
A fused four ring compound occurring free or combined in galls. Isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used in research and as a dye.
A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.
A plant genus of the family ROSACEAE. The common names of chokeberry or chokecherry are also used for some species of PRUNUS.
A trihydroxybenzene or dihydroxy phenol that can be prepared by heating GALLIC ACID.
Measurement and evaluation of the components of substances to be taken as FOOD.
A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida that is a small family with a single genus.
A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.
A plant species of the family VACCINIUM known for the sour fruit which is sometimes used for urinary tract infections.
A group of 3-hydroxy-4-keto-FLAVONOIDS.
A class of phenolic acids related to chlorogenic acid, p-coumaric acid, vanillic acid, etc., which are found in plant tissues. It is involved in plant growth regulation.
Regular course of eating and drinking adopted by a person or animal.
A plant genus of the family MALVACEAE. Members contain CITRIC ACID; MALATES; ANTHOCYANINS; FLAVONOIDS; GLYCOSIDES; DIETARY FIBER; and LIGNANS. Hibiscus sabdariffa is common constituent of HERBAL TEAS. Hibiscus cannabinus is a source of hemp fiber for TEXTILES.
Several plant species of the genus VACCINIUM known for the edible blueberry fruit.
A genus in the family ROSACEAE of shrubs and small trees native to the North Temperate Zone. It is best known for a traditional medication for the heart.

Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. (1/1083)

Identification of common dietary substances capable of affording protection or modulating the onset and severity of arthritis may have important human health implications. An antioxidant-rich polyphenolic fraction isolated from green tea (green tea polyphenols, GTPs) has been shown to possess anti-inflammatory and anticarcinogenic properties in experimental animals. In this study we determined the effect of oral consumption of GTP on collagen-induced arthritis in mice. In three independent experiments mice given GTP in water exhibited significantly reduced incidence of arthritis (33% to 50%) as compared with mice not given GTP in water (84% to 100%). The arthritis index also was significantly lower in GTP-fed animals. Western blot analysis showed a marked reduction in the expression of inflammatory mediators such as cyclooxygenase 2, IFN-gamma, and tumor necrosis factor alpha in arthritic joints of GTP-fed mice. Histologic and immunohistochemical analysis of the arthritic joints in GTP-fed mice demonstrated only marginal joint infiltration by IFN-gamma and tumor necrosis factor alpha-producing cells as opposed to massive cellular infiltration and fully developed pannus in arthritic joints of non-GTP-fed mice. The neutral endopeptidase activity was approximately 7-fold higher in arthritic joints of non-GTP-fed mice in comparison to nonarthritic joints of unimmunized mice whereas it was only 2-fold higher in the arthritic joints of GTP-fed mice. Additionally, total IgG and type II collagen-specific IgG levels were lower in serum and arthritic joints of GTP-fed mice. Taken together our studies suggest that a polyphenolic fraction from green tea that is rich in antioxidants may be useful in the prevention of onset and severity of arthritis.  (+info)

Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3'-digallate. (2/1083)

Previous studies in our laboratory have shown that the major green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), suppressed autophosphorylation of epidermal growth factor (EGF) receptor induced by EGF in human A431 epidermoid carcinoma cells. In this study, we examined the inhibitory effects of black tea polyphenols, including theaflavin (TF-1), a mixture (TF-2) of theaflavin-3-gallate (TF-2a) and theaflavin-3'-gallate (TF-2b), theaflavin-3,3'-digallate (TF-3) and the thearubigin fraction on the autophosphorylation of the EGF and PDGF receptors in A431 cells and mouse NIH3T3 fibroblast cells, respectively. First, we examined the effects of these polyphenols on the proliferation of A431 and NIH3T3 cells. Both EGCG and TF-3 strongly inhibited the proliferation of A431 and NIH3T3 cells more than the other theaflavins did. In cultured cells with pre-treatment of tea polyphenol, TF-3 was stronger than EGCG on the reduction of EGF receptor and PDGF receptor autophosphorylation induced by EGF and PDGF, respectively. Other theaflavins slightly reduced the autophosphorylation of the EGF and PDGF receptors; furthermore, TF-3 could reduce autophosphorylation of the EGF receptor (or PDGF receptor) even with co-treatment with EGF (or PDGF) and TF-3, but EGCG was inactive under these conditions. In addition, TF-3 was stronger than EGCG in blocking EGF binding to its receptor. These results suggest that not only the green tea polyphenol, EGCG, but also the black tea polyphenol, TF-3, have an antiproliferative activity on tumor cells, and the molecular mechanisms of antiproliferation may block the growth factor binding to its receptor and thus suppress mitogenic signal transduction.  (+info)

Prostate cancer chemoprevention by green tea: in vitro and in vivo inhibition of testosterone-mediated induction of ornithine decarboxylase. (3/1083)

Recently, we have shown that ornithine decarboxylase (ODC), a rate-controlling enzyme in the polyamine biosynthetic pathway, is overexpressed in prostate cancer (PCA) and prostatic fluid in humans (R. R. Mohan et al., Clin. Cancer Res., 5: 143-147, 1999). ODC is also characterized as an androgen-responsive gene, and the androgenic stimulation regulates the development and growth of both normal and tumorigenic prostate cells. Thus, chemopreventive approaches aimed toward the modulation of ODC could be effective against PCA. Green tea polyphenols (GTPs) possess strong chemopreventive properties against a variety of animal tumor models and in some human epidemiological studies. At least two epidemiological studies have suggested that people who consume tea regularly may have a decreased risk of PCA. In this study, we investigated the effect of GTPs against testosterone-mediated induction of ODC in human prostate carcinoma cells, LNCaP as an in vitro model, and in Cpb:WU rats and C57BL/6 mice as in vivo models. Treatment of LNCaP cells with testosterone resulted in induction of ODC activity in a dose-dependent manner. Pretreatment of the cells with GTPs resulted in a significant inhibition of testosterone-caused induction of ODC activity in a dose-dependent manner. Similar effects of GTPs were observed in anchorage-independent growth assay of LNCaP cells where pretreatment of the cells with GTP was found to result in dose-dependent inhibition of colony formation. Testosterone treatment of the cells resulted in a significant increase in the level of ODC mRNA, and this increase was almost completely abolished by prior treatment of the cells with GTPs. The administration of testosterone (10 mg/kg body weight, i.p.) to sham-operated and castrated Cpb:WU rats resulted in 2- and 38-fold increases in ODC activity, respectively, in the ventral prostate. Oral feeding of 0.2% GTPs in drinking water for 7 days before testosterone administration resulted in 20 and 54% decreases in testosterone-caused induction of ODC activity in sham-operated and castrated rats, respectively. Similar results were obtained with C57BL/6 mice, where testosterone treatment at similar dosage resulted in a 2-fold increase in ODC activity in the ventral prostate and prior oral feeding with 0.2% GTPs resulted in 40% inhibition in this induction.  (+info)

Histological analysis and ancient DNA amplification of human bone remains found in caius iulius polybius house in pompeii. (4/1083)

Thirteen skeletons found in the Caius Iulius Polybius house, which has been the object of intensive study since its discovery in Pompeii 250 years ago, have provided an opportunity to study either bone diagenesis by histological investigation or ancient DNA by polymerase chain reaction analysis. DNA analysis was done by amplifying both X- and Y-chromosomes amelogenin loci and Y-specific alphoid repeat locus. The von Willebrand factor (vWF) microsatellite locus on chromosome 12 was also analyzed for personal identification in two individuals showing alleles with 10/11 and 12/12 TCTA repeats, respectively. Technical problems were the scarcity of DNA content from osteocytes, DNA molecule fragmentation, microbial contamination which change bone structure, contaminating human DNA which results from mishandling, and frequent presence of Taq DNA polymerase inhibiting molecules like polyphenols and heavy metals. The results suggest that the remains contain endogenous human DNA that can be amplified and analyzed. The amplifiability of DNA corresponds to the bone preservation and dynamics of the burial conditions subsequent to the 79 A.D. eruption.  (+info)

Quinol-glutathione conjugate-induced mutation spectra in the supF gene replicated in human AD293 cells and bacterial MBL50 cells. (5/1083)

Hydroquinone is a nephrocarcinogen in rats but generally tests negative in standard mutagenicity assays. However, 2,3,5-tris-(glutathion-S-yl)hydroquinone, a potent nephrotoxic metabolite of hydroquinone, and 2-bromo-bis-(glutathion-S-yl)hydroquinone, another cytotoxic quinol-glutathione (GSH) conjugate, cause extensive single strand breaks in DNA in a manner that is dependent on the formation of reactive oxygen species. We, therefore, investigated whether quinol-GSH conjugates have the potential to behave as genotoxicants. The shuttle vector pSP189, containing the supF gene, was treated with 2,3,5-tris-(glutathion-S-yl)hydroquinone and replicated in both human AD293 cells and Escherichia coli MBL50 cells. The mutation frequency increased 4.6- and 2.6-fold in human AD293 and bacterial MBL50 cells, respectively. Base substitutions were the major type of mutations, and they occurred predominantly at G:C sites in both cell types. A high frequency of deletions (30%), including < 10- and > 10-bp deletions, were observed in AD293-replicated plasmids. The most common types of mutations in AD293 cells were G:C to A:T transitions (33.8%) and G:C to T:A (29.4%) and G:C to C:G (19.1%) transversions. In MBL50 cells, the major mutations were G:C to T:A (33.8%) and G:C to C:G (31.3%) transversions and G:C to A:T transitions (27.5%). The mutation spectra were similar to those reported for *OH-induced mutations, suggesting that *OH generated from polyphenolic-GSH conjugates not only plays a role in cytotoxicity but also provides a basis for their mutagenicity and carcinogenicity.  (+info)

Dietary supplementation of grape polyphenols to rats ameliorates chronic ethanol-induced changes in hepatic morphology without altering changes in hepatic lipids. (6/1083)

Increase in oxidative stress after chronic ethanol consumption can result in hepatic injury. Because polyphenolic compounds can offer antioxidant protection to the cardiovascular system, this study was designed to investigate whether dietary supplementation of polyphenols from grapes may ameliorate hepatic injury resulting from chronic ethanol consumption. Male Sprague-Dawley rats were administered the following diets for 2 mo: 1) Lieber-DeCarli (L-D) diet with isocaloric amount of maltose instead of ethanol (Basal), 2) the L-D diet with 50g/L ethanol (EtOH); 3) L-D diet with 50 mg/L of grape polyphenols (GP) and 4) ethanol diet with GP (EtOH + GP). Rats given EtOH or EtOH + GP diets had significantly more hepatic triacylglycerols (P < 0.0001) and lipid peroxidation products (P < 0.01) compared with those given the Basal and GP diets. In addition, ethanol ingestion also decreased significantly (P < 0.01) the proportion of 16:0 and increased 18:0 and 18:1 in hepatic phospholipids, suggesting a perturbation of the de novo fatty acid biosynthesis pathways. However, GP supplementation alone and GP added to the ethanol diet did not alter the lipid changes mediated by ethanol except for the levels of 22:6(n-3) which were significantly (P < 0.05) higher in the EtOH + GP group than in the EtOH group. Despite a lack of gross lipid changes, histologic assessment showed significantly (P < 0.05) less hepatic damage in the GP + EtOH group compared with the EtOH group. These results clearly distinguished ethanol-mediated changes in hepatic morphology from the changes in hepatic lipids and further demonstrated the ability of GP to ameliorate hepatic damage resulting from chronic ethanol consumption.  (+info)

Polyphenol tannic acid inhibits hydroxyl radical formation from Fenton reaction by complexing ferrous ions. (7/1083)

Tannic acid (TA), a plant polyphenol, has been described as having antimutagenic, anticarcinogenic and antioxidant activities. Since it is a potent chelator of iron ions, we decided to examine if the antioxidant activity of TA is related to its ability to chelate iron ions. The degradation of 2-deoxyribose induced by 6 microM Fe(II) plus 100 microM H2O2 was inhibited by TA, with an I50 value of 13 microM. Tannic acid was over three orders of magnitude more efficient in protecting against 2-deoxyribose degradation than classical *OH scavengers. The antioxidant potency of TA was inversely proportional to Fe(II) concentration, demonstrating a competition between H2O2 and AT for reaction with Fe(II). On the other hand, the efficiency of TA was nearly unchanged with increasing concentrations of the *OH detector molecule, 2-deoxyribose. These results indicate that the antioxidant activity of TA is mainly due to iron chelation rather than *OH scavenging. TA also inhibited 2-deoxyribose degradation mediated by Fe(III)-EDTA (iron = 50 microM) plus ascorbate. The protective action of TA was significantly higher with 50 microM EDTA than with 500 microM EDTA, suggesting that TA removes Fe(III) from EDTA and forms a complex with iron that cannot induce *OH formation. We also provided evidence that TA forms a stable complex with Fe(II), since excess ferrozine (14 mM) recovered 95-96% of the Fe(II) from 10 microM TA even after a 30-min exposure to 100-500 microM H2O2. Addition of Fe(III) to samples containing TA caused the formation of Fe(II)n-TA, complexes, as determined by ferrozine assays, indicating that TA is also capable of reducing Fe(III) ions. We propose that when Fe(II) is complexed to TA, it is unable to participate in Fenton reactions and mediate *OH formation. The antimutagenic and anticarcinogenic activity of TA, described elsewhere, may be explained (at least in part) by its capacity to prevent Fenton reactions.  (+info)

Red wine inhibits monocyte chemotactic protein-1 expression and modestly reduces neointimal hyperplasia after balloon injury in cholesterol-Fed rabbits. (8/1083)

BACKGROUND: Wine consumption decreases the risk of myocardial infarction. Intimal hyperplasia contributes to restenosis after angioplasty. Local ethanol delivery inhibits intimal hyperplasia after balloon injury in rabbit iliac and pig coronary arteries. The effects of wine consumption on intimal response and monocyte chemotactic protein-1 (MCP-1) expression were studied in cholesterol-fed rabbits. METHODS AND RESULTS: Male rabbits were fed a 2% cholesterol diet together with red wine (12.5% vol, 5 mL/kg body wt per day; n=7), white wine (13.3% vol, 5 mL/kg body wt per day; n=7), or no wine as a control (n=8) for 6 weeks. A balloon injury of the abdominal aorta was performed at the end of the third week. Abdominal aortas were harvested at the end of 6 weeks. Neointimal hyperplasia was measured morphometrically. MCP-1 expression was determined by Northern blot, in situ hybridization, and immunohistochemistry. Rabbits fed red wine had significantly less neointimal hyperplasia than did control rabbits (intima/media area ratio 0.59+/-0.05 [red wine group] versus 0.79+/-0.07 [control group], P<0.05). However, rabbits fed white wine showed a trend (but not significant) toward less intimal response compared with control rabbits (intima/media area ratio 0.65+/-0.04 [white wine group] versus 0.79+/-0.07 [control group], P=0.165). Both red wine and white wine significantly reduced MCP-1 mRNA and protein expression in the aorta. CONCLUSIONS: Long-term consumption of red wine and white wine inhibits MCP-1 expression, and in the small number of animals studied, red wine modestly reduces neointimal hyperplasia. Since red wine exhibits higher antioxidant capacity than does white wine, the decreased intimal response might be partly attributed to its antioxidant effects.  (+info)

TY - JOUR. T1 - Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase. AU - Li, Changhong. AU - Allen, Aron. AU - Kwagh, Jae. AU - Doliba, Nicolai M.. AU - Qin, Wei. AU - Najafi, Habiba. AU - Collins, Heather W.. AU - Matschinsky, Franz M.. AU - Stanley, Charles A.. AU - Smith, Thomas J.. PY - 2006/4/14. Y1 - 2006/4/14. N2 - Insulin secretion by pancreatic β-cells is stimulated by glucose, amino acids, and other metabolic fuels. Glutamate dehydrogenase (GDH) has been shown to play a regulatory role in this process. The importance of GDH was underscored by features of hyperinsulinemia/hyperammonemia syndrome, where a dominant mutation causes the loss of inhibition by GTP and ATP. Here we report the effects of green tea polyphenols on GDH and insulin secretion. Of the four compounds tested, epigallocatechin gallate (EGCG) and epicatechin gallate were found to inhibit GDH with nanomolar ED50 values and were therefore found to be as potent as the physiologically ...
Title:Downstream Carcinogenesis Signaling Pathways by Green Tea Polyphenols: A Translational Perspective of Chemoprevention and Treatment for Cancers. VOLUME: 15 ISSUE: 1. Author(s):Guohua Hu, Lei Zhang, Yefei Rong, Xiaoling Ni and Yihong Sun. Affiliation:Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.. Keywords:Cancer, chemoprevention, green tea, polyphenols, treatment.. Abstract:Green tea is one of the most popular beverages around the world. For several decades, numerous epidemiological, preclinical and clinical studies have demonstrated that green tea polyphenols (GTPs), especially epigallocatechin-3-gallate (EGCG) have cancer-preventing effects on various cancers. In this review, we present inhibition of carcinogenesis in different animal models by GTPs or EGCG, including prostate cancer, bladder cancer, breast cancer, intestinal cancer, colon cancer, gastric cancer, lung cancer, oral cancer and skin cancer. In vitro studies showed that ...
Polyphenols are secondary metabolites of plants and are generally involved in defense against ultraviolet radiation or aggression by pathogens. In the last decade, there has been much interest in the potential health benefits of dietary plant polyphenols as antioxidant. Epidemiological studies and associated meta-analyses strongly suggest that long term consumption of diets rich in plant polyphenols offer protection against development of cancers, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases. Here we present knowledge about the biological effects of plant polyphenols in the context of relevance to human health.
Pink Guava waste obtained after juice processing still contains large amounts of polyphenols, which act as antioxidants. Our previous study has indicated that pink guava waste obtained after juice processing still contain large amounts of polyphenols, which act as antioxidants. The effect of different solvents, mix concentration between MethanollWater, extraction time and ratio waste/solvent on the yield of etracted antioxidants from three sources of pink guava processing wastes to optimize the extraction was investigated . Folin-Ciocalteau method was used to determine the total polyphenols content. Total polyphenols content from 0.03 to 0.12 mg/g and the highest is by using methanol as a solvent. The highest polyphenols content at mix concentration between 60% methanOl/water, concentration of polyphenols increased by increasing extraction time and the highest polyphenols extraction observed when using I g waste/25 ml methanol/water 60% as solvent. Membrane technologies are presented as ...
TY - JOUR. T1 - Chemoprevention by lipid-soluble tea polyphenols in diethylnitrosamine/phenobarbital-induced hepatic pre-cancerous lesions. AU - Shen, Ting. AU - Khor, Soo Chin. AU - Zhou, Fan. AU - Duan, Ting. AU - Xu, Yu Ying. AU - Zheng, Yi Fan. AU - Hsu, Stephen. AU - De Stefano, Jamie Ann. AU - Yang, Jun. AU - Xu, Li Hong. AU - Zhu, Xin Qiang. N1 - Publisher Copyright: © 2014, International Institute of Anticancer Research. All rights reserved.. PY - 2014/2/1. Y1 - 2014/2/1. N2 - Background: Green tea polyphenols (GTPs) have been proposed as promising candidates for chemoprevention. However, GTPs levels are maintained relatively low in the blood and are chemically-unstable. Lipid-soluble tea polyphenols (LTPs) are products of modified GTPs with ester linkage with fatty acids. LTPs are lipophilic and expected to provide improved absorption and utilization in the body compared with water-soluble polyphenols. The current study was designed to investigate the chemo-preventive property and the ...
Cardiovascular disease is a chronic disease influenced by many factors, with activated blood platelets being one of them. Platelets play a central role in the formation of plaques within blood vessels, contributing to early inflammatory events. Consumption of diets rich in plant-based products protects against the development of cardiovascular disease. Polyphenols, which are secondary plant metabolites found in a wide range of foodstuffs and beverages, may be partially responsible for these effects. Their protective properties include inhibitory effects on platelet function in vitro and in vivo. However, the bioavailability of many polyphenols is poor and it is unclear whether sufficient quantities can be obtained by dietary means to exert protective effects. Consequently, this review summarizes 25 well-controlled human intervention studies examining the effect of polyphenol-rich diets on platelet function. These studies report a huge variety of research methods, study designs, and study ...
Title: Polyphenols: Biological Activities, Molecular Targets, and the Effect of Methylation. VOLUME: 1 ISSUE: 3. Author(s):K. R. Landis-Piwowar and Q. P. Dou. Affiliation:Karmanos Cancer Institute, 540.01 HWCRC 4100 John R Road, Detroit, Michigan 48201-2013, USA.. Keywords:Proteasome inhibitor, molecular target, natural product, drug discovery, anticancer. Abstract: Polyphenolic compounds are widely distributed in the plant kingdom and the anticancer benefits obtained from their consumption have been studied extensively. However, polyphenols are subject to various biotransformation reactions within the human body including methylation. Likewise, naturally occurring polyphenols may contain O-methylations in place of the hydroxyls of the parent compounds. While some studies suggest that methylations can increase the bioavailability of polyphenols, other studies indicate a decrease in the anticancer benefits of methylated polyphenols. This review will focus on the cellular activities of ...
Introduction: Cerebral ischemia/reperfusion injury following cardiac arrest and cardiopulmonary resuscitation (CPR) has been demonstrated. Oxidant injury plays a critical role in the process. Since tea polyphenols from green tea are efficient free radical and singlet oxygen scavengers. We therefore sought to investigate if tea polyphenols would be effective in a rat model of asphyxial cardiac arrest.. Hypothesis: We hypothesized that tea polyphenols could reduce cerebral ischemia/reperfusion injury and consequently improve the outcome of CPR via counteracted the oxidant injury.. Methods: Male Sprague-Dawley rats, weighing 200-400 g, were induced cardiac arrest by clamping the trachyeal tubes. Cardiac arrest was determined by loss of aortic pulsations and mean aortic pressure , 10mmHg. At the end of 8 min of clamping, mechanical chest compression at a rate of 180/min was performed. Ventilation was started with room air at 70 breaths per min and tidal volume adjusted to 6 ml/kg. Epinephrine was ...
Because polyphenols may have beneficial effects on dyslipidemia, which accelerates atherosclerosis in diabetes, we examined the effect of polyphenols on hepatocellular AMP-activated protein kinase (AMPK) activity and lipid levels, as well as hyperlipidemia and atherogenesis in type 1 diabetic LDL receptor-deficient mice (DMLDLR−/−). In HepG2 hepatocytes, polyphenols, including resveratrol (a major polyphenol in red wine), apigenin, and S17834 (a synthetic polyphenol), increased phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase (ACC), and they increased activity of AMPK with 200 times the potency of metformin. The polyphenols also prevented the lipid accumulation that occurred in HepG2 cells exposed to high glucose, and their ability to do so was mimicked and abrogated, respectively, by overexpression of constitutively active and dominant-negative AMPK mutants. Furthermore, treatment of DMLDLR−/− mice with S17834 prevented the decrease in AMPK and ACC ...
PALMISCIANO BEDE, Teresa et al. Effect of the intake of liquids rich in polyphenols on blood pressure and fat liver deposition in rats submitted to high-fat diet. Nutr. Hosp. [online]. 2015, vol.31, n.6, pp.2539-2545. ISSN 1699-5198. http://dx.doi.org/10.3305/nh.2015.31.6.8655.. Introduction: seeking better quality of life, the number of studies on functional foods and disease prevention is growing fast. Whole red grape juice (WRGJ) and red wine (RW) stand out, which are rich in polyphenols, showing antioxidant and anti-inflammatory activity. Objective: to evaluate the effect of WRGJ and RW intake and resveratrol solution (RS) on blood pressure and fat liver deposition of rats fed with high-fat diet. Material and Methods: during 60 days, 50 Rattus norvegicus Wistar Albino adults were divided into: control group (CG) - balanced diet, hyperlipidic group (HG), red wine group (RWG), grape juice group (JGG) and resveratrol group (RG) - hyperlipidic diet. Feed and water were offered ad libttum to all ...
In this study we found that ERα plays a key role in mediating the activation of eNOS in response to black tea polyphenols. In particular, we found that ERα is phosphorylated on Ser-118 in response to black tea polyphenol-mediated p38 MAPK activation. This ERα phosphorylation is required for p38 MAPK downstream signaling to Akt and eNOS that mediates black tea polyphenol-induced eNOS activation. We were able to implicate Ser-118 as a critical residue in this process as we observed ERα Ser-118 phosphorylation in response to black tea polyphenols and mutation of this residue abrogated polyphenol-induced eNOS activation in COS cells. This residue also appeared important for the functional association of p38 MAPK with ERα as mutants lacking this site did not associate with p38 MAPK in response to black tea polyphenols. These data suggest a novel adaptor function of ERα that integrates p38 MAPK signaling with downstream targets.. The rapidity of the response to black tea polyphenols suggests a ...
Blood lipid,blood viscosity,coagulation time,platelet agglutination rate,lipid hyperoxide and carry lipoprotein level were determined using Transansio automatic biochemical analyzer,automatic rinse spin rheometer and Chrono log 400 platelet agglutinating meter respectively The treatment of 200mg kg -1 d -1 tea polyhenlos could decrease TC,TG,LDL C,apoB 100 and LPO(p0 01) in blood significantly,while HDL C and blood SOD were increased(p0 01) The function of apoA 1,blood visciosity,PtA and HCT were decreased(p0 05) CgT was prolonged. The results implicated that tea polyphenols could adjust blood lipid and possessed the antioxidative activity to lipid,So showed the clinical value
Polyphenols are a diverse group of phytonutrients that determine colours of the fruits and vegetables, and protect the plants from diseases and invasion of external microorganisms. In fact, polyphenols are a part of defense mechanisms of the plants.. Polyphenols are classified into two major groups, flavonoids and phenolic compounds. A subtype of phenolic compounds is lignans, which are one of the major subclasses of phytoestrogens as well.. See Flavonoids and Phenolic Compounds.. ...
The possible cancer-preventive activity of tea is receiving a great deal of attention. Information on the bioavailability and disposition of tea polyphenols such as EGCG, EGC, and EC is important for understanding the biological effects of tea. To our knowledge, this is the first report on the absorption, distribution, and elimination of EGCG, EGC, and EC in rodents that have been used extensively in the studies of cancer chemoprevention. Although there are similarities in their chemical structures (fig. 1), EGCG, EGC, and EC displayed different pharmacokinetics. When DGT was used as the source of tea polyphenols by i.v. injection, the K12 andK21 (the distribution rate constants between the central compartment and the peripheral compartment) were similar for EGC and EC. But for EGCG, the K12 was 3-fold larger than K21, suggesting that EGCG tends to distribute into the peripheral compartment (table 1). The longert1/2β and smaller CL of EGCG also indicate that EGCG could stay in the body for a ...
Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese
Abstract: Background: The optimal parameters of separation and purification of polyphenols from Pericarpium Granati were determined and the antibacterial activities against S. mutans in vitro were investigated. Methodology: Through comparing the static adsorption/desorption properties of five kinds of tested macroporous resins for polyphenols, HPD-450 resin was selected to investigate optimal purification parameters by dynamic curve experiments. The optimal purification conditions as follows: 9.0 BV of feeding solution at concentration of 3.2 mg mL 1 through the column at 3.0 BV h 1, then for desorption 60% ethanol-aqueous 3.5 BV at 2.0 BV h 1 eluted. The content of polyphenols was increased from 34.9±1.6% to 71.1±3.1% with a recovery yield of 85.5±3.7% according to the optimal parameters. Results: The present study showed that the MIC of purity of polyphenols was 6.25 mg mL 1. The acidogenicity of S. mutans can be significantly inhibited when the concentration was up to or higher than 1.56 ...
The chemopreventive potential of a wide variety of structurally diverse polyphenols were initially evaluated for their apoptotic-inducing activity, using HCT-8 ileocecal adenocarcinoma cells. Apoptosis was measured by fluorescence microscopy and morphological criteria. (-)-Epigallocatechin-3-gallate (EGCG), theaflavins, curcumin and the grape seed polymer were found to be the most potent inducers of apoptosis, at concentrations physiologically relevant to humans. In contrast to the observation in HCT-8 cancerous cells, polyphenol-induced apoptosis was substantially lower in ICE-6 non-cancerous epithelial cells. The aforementioned active apoptotic polyphenols were subsequently assessed for their ability to activate direct and indirect caspases. Activation of downstream caspase- 3 and -7, and upstream caspase-9, in HCT-8 cells, implies that an intrinsic (intracellular) caspase cascade is involved in polyphenol-induced apoptosis. Potential pro-oxidant and/or antioxidant mechanisms and ...
Fingerprint Dive into the research topics of Green tea polyphenols and 1-α-OH-vitamin D ,sub,3,/sub, attenuate chronic inflammation-induced myocardial fibrosis in female rats. Together they form a unique fingerprint. ...
To account for the observed anticancer properties of plant polyphenols, we have earlier proposed a mechanism which involves the mobilization of endogenous copper ions by polyphenols leading to the gen
Figure 6: Antioxidant, Cytotoxic, and Antiproliferative Activities and Total Polyphenol Contents of the Extracts of |i|Geissospermum reticulatum|/i| Bark
The polyphenols present in green tea help prevent the spread of prostate cancer by targeting molecular pathways that shut down the proliferation and spread of tumor cells, as well as inhibiting the growth of tumor nurturing blood vessels, according to research published in the December 1 issue of Cancer Research.
TY - JOUR. T1 - The polyphenol delphinidin induces antioxidant effects in human umbilical vein endothelial cells through activation of endogenous glutathione: importance of using relevant concentration in in vitro systems. AU - Goszcz, Katarzyna. AU - Duthie, Garry. AU - Stewart, Derek. AU - Megson, Ian. N1 - © 2017, Published by the BMJ Publishing Group Limited.. PY - 2017/4/1. Y1 - 2017/4/1. N2 - Polyphenols are regarded to have a wide range of health-promoting effects. Increased consumption of polyphenol-rich food is known to be associated with numerous cardioprotective effects. Polyphenols have been shown to improve endothelial function, inhibit abnormal platelet aggregation, reduce inflammation and improve plasma lipid profiles. Moreover, polyphenols have been widely recognised as powerful antioxidants. Given that oxidative stress plays a key role in initiation and progression of atherosclerosis, antioxidant therapy with polyphenols has potential. However, the concentrations required to ...
Research has called into question the role of plant polyphenols in cardiovascular health, by finding that their supposed anti-platelet activities are only relevant at high, and physiologically unattainable, concentrations.
Polyphenols, occurring in fruit and vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products, have been demonstrated to have clear antioxidant properties in vitro, and many of their biological actions have been attributed to their intrinsic reducing capabilities. However, it has become clear that, in complex biological systems, polyphenols exhibit several additional properties which are yet poorly understood. Apoptosis is a genetically controlled and evolutionarily conserved form of cell death of critical importance for the normal embryonic development and for the maintenance of tissue homeostasis in the adult organism. The malfunction of the death machinery may play a primary role in various pathological processes, since too little or too much apoptosis can lead to proliferative or degenerative diseases, respectively. Cancer cells are characterized by a deregulated proliferation, and/or an inability to undergo programmed cell death. A large body of evidence indicates that
The present study shows that oral administration of RWPC from 2 different sources (ie, Provinol and RWPC1) to the rat modifies hemodynamic parameters and vascular reactivity. In vivo treatment of normotensive rats with RWPC decreased arterial blood pressure without any change in heart rate. In addition, RWPC treatment is associated with changes in the vascular reactivity of the thoracic aorta. RWPC treatment enhanced endothelium-dependent relaxation in response to acetylcholine but also induced increased expression of COX-2 with subsequent increased release of endothelial thromboxane A2 (TXA2), which opposes the NO-induced hyporeactivity of the aorta to norepinephrine, which is consequent on increased iNOS expression.. In previous studies, we reported that RWPCs from both Provinol and RWPC1 were able to produce ex vivo endothelium-dependent relaxation in rat aortic rings as a result of enhanced NO synthesis.11,12 The present study provides evidence that in vivo administration of these 2 sources ...
To feel young and look great at any age is the ultimate in anti-aging. It really is possible to attain that fountain of youth if you eat the right foods on a daily basis, drink plenty of refreshing beverages, exercise, and stay as stress-free as possible. There is a myriad of health foods popping up in the market. Most of them are helpful, but if you want to cut to the chase…Just what are the right foods? The ones that are packed with anti-aging molecules that can keep you young forever?. Foods rich in polyphenols can slow down the aging process. And, there are some studies that show that polyphenols may even reverse the effects of aging. Youve heard much about three of these top 5 foods, but theres two more you didnt think about as top health foods. Herea a delicious list of the top 5 foods to keep young.. Green Tea: Drink 2 or 3 cups of green tea daily for maximum health and beauty benefits.. Blueberries: Blueberries help your circulation and help prevent atherosclerosis; they improve ...
A recent study suggests that taking a combination of grape and apple polyphenols may increase the time to exhaustion for athletes by almost 10%. This means they are able to work out longer and therefore get increased benefits from an exercise session. Participants in the study included 48 physically active men with an
...Philadelphia PA December 19 2013 Polyphenols found in tea manifest... These results support a new role for milk as an ideal platform for de...The majority of extractable polyphenols in tea are flavan-3-ols commo...In one experiment human colorectal cancer cells (HT-29) were grown fo...,A,new,role,for,milk:,Delivering,polyphenols,with,anti-cancer,activity,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Fruits, especially berries, and vegetables are good sources of polyphenols. Learn more about polyphenols and their health-promoting properties.
The PPhIT study aimed to extend a previous dietary intervention (FAVRIT) that had been shown to improve microvascular function in hypertensive subjects. This study develops those findings by showing that increasing polyphenol content with the addition of berries and dark chocolate potentially has additional benefits on microvascular function and CVD risk. The ideal combination of polyphenol-rich foods for cardiovascular health remains under debate. It was hypothesised that this diet would provide increased benefits to cardiovascular health and, importantly, given its palatability, be easily adopted by the general public.. The primary endpoint of the PPhIT study was between-group change in maximum FBF response to the endothelium-dependent vasodilator, ACh. Between-group comparison showed that those subjects who received a high-polyphenol diet had a significantly greater improvement in maximum % response to ACh, compared with the low-polyphenol group (p=0.02). This suggests that increasing ...
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00 ...
To refresh organic chemistry-challenged minds, polyphenols are characterized by the presence of multiple phenolic rings (ie, benzene rings with hydroxyl groups). They are produced by plants to defend against ultraviolet radiation or pathogens. Polyphenols are responsible for some of the color, flavor, odor, and bitterness of fruits, vegetables, grains, and such beverages as tea and coffee. They function as antioxidants and have been reported to bestow health benefits, including protection from cardiovascular disease, cancer, infections, and a variety of other conditions ...
REFERENCES. 1. Stea TH, Mansoor MA, Wandel M, Uglem S, FrolichW. Changes in predictors and status of homocysteine in young male adults after a dietary intervention with vegetables, fruits and bread. Eur J Nutr. 2008; 47(4):201-9. http://dx.doi.org/10.1007/s00394008-0714-y [ Links ] 2. Heidemann C, Schulze MB, Franco OH, van DamRM, Mantzoros CS, Hu FB. Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women. Circulation. 2008; 118(3):230-7. http://dx.doi.org/10.1161/CIRCULATIONAHA.108.771881 [ Links ] 3. Hanhineva K, Törrönen R, Bondia-Pons I, PekkinenJ, Kolehmainen M, Mykkänen H, et al. Impact of dietary polyphenols on carbohydrate metabolism. Int J Molecular Sci. 2010; 11(4):1365-402. http://dx.doi.org/10.3390/ijms11041365 [ Links ] 4. Neveu V, Perez-Jiménez J, Vos F, Crespy V, duChaffaut L, Mennen L, et al. Phenol-Explorer: An online comprehensive database on polyphenol contents in foods. Database. 2010. ...
Increased intakes of polyphenols may reduce the risk of cardiovascular disease by an impressive 46%, according to the results of the international PREDIMED (Prevencion con Dieta Mediterranea) study.
How to boost your intake of polyphenol antioxidants. polyphenols have wiki how to boost your intake of polyphenol eat and drink polyphenol-rich foods. These
The protective effect of polyphenol-rich haskap berry extracts against tobacco-specific nitrosamine ketone (NNK)-induced DNA damage was studied in vitro. Normal lung epithelial BEAS-2B cells were exposed to NNK, and to its precursor, 4-[(acetoxymethyl) nitrosamino]-1-(3-pyridyl)-1-butanone (NNKOAc), to induce DNA damage. Polyphenols present in haskap berries were extracted using ethanol and water, separately. Quercetin-3-O-glucoside (Q3G) and cyanidin-3-O-glucoside (C3G) were used as the reference compounds. BEAS-2B cells were pre-incubated with non-cytotoxic concentrations of haskap extracts, Q3G, and C3G separately, and investigated for their protective effects against NNK- and NNKOAc-induced DNA damage. Pre-incubation of BEAS-2B cells with haskap extracts, Q3G, and C3G, significantly suppressed the NNK- and NNKOAc-induced DNA strand breaks, and intracellular reactive oxygen species generation. The protective effect of haskap extracts could be related to their polyphenol content and high ...
The antioxidant polyphenols in apple skin may reduce inflammation and improve heart & gut health. Read on to discover how apples can help you.
A new protein is coming to town and it is something every bodybuilder is going to want to try. The secret to this new protein is something called polyphenols, which are plant extracts that are known to help increase the bodys own fat burning effect. Polyphenols can be found in many plant varieties, but some of the most potent come from tea extracts like green and black tea. These polyphenols are proven to help the body burn more fat calories per workout and to keep burning fat all day long. Unfortunately you need to drink a lot of green tea to get the full fat burning effects or take a green tea supplement three times per day. However, a new protein source is now available that contains natural polyphenols similar to what is found in green tea and is proven in scientific literature to increase the fat burning effect in the bodys mitochondria. This is the holy grail of all protein supplements, to be able to burn fat while promoting lean muscle growth and it is finally available. Lipotropic ...
What foods can help fight the risk of chronic inflammation?. A new study headed by researchers at the University of Liverpools Institute of Ageing and Chronic Disease suggests that polyphenols can help protect against inflammation, cancer and other chronic diseases. Polyphenols are basically micronutrients that act as antioxidants-they are mainly found in diets rich in fruits and veggies.. Of course, the health effects of polyphenols depend on their bioavailability and how much is consumed.. T-lymphocytes (T-cells) are white blood cells that travel the body, looking for infections and cellular abnormalities.. They aid cytokines-molecules that help stimulate the movement of cells towards sites of trauma, infection or inflammation. In essence, cytokines are controlled by (polyphenol-rich) fruit and veggie intake.. The new study, published in the May issue of the British Journal of Nutrition, looks at the effectiveness of various polyphenols in moderating cytokine release. Results showed that ...
June 29, 2010. Polyphenols antioxidant health benefits may come at a cost to some people. Penn State researchers found that eating certain polyphenols decreases the amount of iron the body absorbs, which can increase a persons risk for developing iron deficiency. The researchers, led by Dr. Okhee Han, assistant professor of nutritional sciences, studied the effects of eating several polyphenols: grape seed extract and EGCG (epigallocatechin-3-gallate), which is found in green tea.. Polyphenols have been known to have many beneficial effects for human health, such as preventing or delaying certain types of cancer, enhancing bone metabolism, decreasing risk of heart disease, and improving bone mineral density, says Han. But so far, not many people have thought about whether or not polyphenols affect nutrient absorption.. The researchers used cells derived from the intestine-where iron absorption takes place-to assess the polyphenols impact. They found that polyphenols bind to iron molecules ...
The Wurzburg-based scientists recruited 33 individuals diagnosed with severe osteoarthritis scheduled for knee replacement surgery (arthroplasty). The volunteers were supplemented with 200 mg per day of Pycnogenol or no supplements (control group) for three weeks leading up to their scheduled surgeries, and synovial fluid samples were collected during surgery to detect and measure the presence of polyphenols.. Results showed that the polyphenols found in Pycnogenol including taxifolin, ferulic acid and catechin were distributed throughout the synovial fluid. On the other hand, taxifolin and ferulic acid were not detected in control group serum samples.. To the best of our knowledge, this is the first study investigating polyphenol concentrations in human synovial fluid samples of patients with osteoarthritis. Similar to the results of serum analysis, mean polyphenol concentrations were similar in the [Pycnogenol] and [control] groups, but taxifolin was only detectable in the [Pycnogenol] group. ...
Barley Malt Treated with Enzymes Increases Polyphenol Content and Antioxidant Activity - Barley malt;Malting period;Enzymatic treatment;Antioxidant;Total polyphenol;
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Polyphenols are compounds found in plants, including flavonoids and phenolic acid, that greatly benefit the human body and help fight disease. This MNT Knowledge Center article explains the benefits of polyphenols and which foods contain them. It also looks at the possible risks and considerations for these chemicals.
Experimental studies have reported on the anti-inflammatory properties of polyphenols. However, results from epidemiological investigations have been inconsistent, and especially studies using biomarkers for assessment of polyphenol intake have been scant. We aimed to characterize the association between plasma concentrations of 35 polyphenol compounds and low-grade systemic inflammation state as measured by high-sensitivity C-reactive protein (hsCRP). A cross-sectional data analysis was performed based on 315 participants in the European Prospective Investigation into Cancer and Nutrition cohort with available measurements of plasma polyphenols and hsCRP. In logistic regression analysis the odds and 95% confidence intervals (CI-s) of elevated serum hsCRP (,3 mg/L) were calculated within quartiles and per standard deviation (SD) higher level of plasma polyphenol concentrations. In multivariable-adjusted model, the sum of plasma concentrations of all polyphenols measured (per SD) was associated ...
A polyphenol antioxidant is a type of antioxidant containing a polyphenolic substructure. Numbering over 4,000 distinct species, many of these compounds have antioxidant activity in vitro but are unlikely to have antioxidant roles in vivo. Rather, they may affect cell-to-cell signaling, receptor sensitivity, inflammatory enzyme activity or gene regulation. From about 500 million years ago, freshwater and terrestrial plants slowly optimized the production of new endogenous antioxidants, such as ascorbic acid (vitamin C), natural phenols (including flavonoids) and polyphenols, tocopherols, etc.[citation needed] A few of these appeared more recently, in the last 50-200 million years, in fruits and flowers of angiosperm plants. In fact, the angiosperms (the flowering plants), the dominant type of plant today (and most of their antioxidant pigments) evolved during the late Jurassic period. The main source of polyphenols is dietary, since they are found in a wide array of phytochemical-bearing ...
The presence of polyphenolic compounds associated with dietary fibre is a characteristic feature of polyphenol-rich plant foods. It was recently reported that soluble dietary fibre is a common constituent of wine. The objective of this work was to ascertain whether significant amounts of wine polyphenols are associated with dietary fibre. Total phenolics, antioxidant capacity, and HPLC analysis were determined in wines and in corresponding dietary fibre solutions obtained after enzymatic treatments and dialysis. Results showed that 35-60% of total polyphenols in red wine and about 9% in white wine are associated with dietary fibre. These polyphenols are not detected by the usual HPLC analytical techniques and consequently may be ignored in most chemical and biological studies - what we call ,the wine polyphenols gap,. Our findings suggest that a significant part of wine polyphenols are not bioaccesible in the human small intestine and reach the colon along with dietary fibre. © 2006 Elsevier ...
TY - JOUR. T1 - Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. AU - Lee, Hsin Hsueh. AU - Yang, Ling-Ling. AU - Wang, Ching Cheung. AU - Hu, Ssu Yao. AU - Chang, Shwu Fen. AU - Lee, Yi-Hsuan. PY - 2003/10/3. Y1 - 2003/10/3. N2 - Neuronal injury in the central nervous system following ischemic insult is believed to result from glutamate toxicity and glucose deprivation. In this study, polyphenols isolated from Scutellaria baicalensis Georgi, including baicalin, baicalein, and wogonin, were investigated for their neuroprotective effects against glutamate/NMDA (Glu/NMDA) stimulation and glucose deprivation in primary cultured rat brain neurons. Cell death was accessed by lactate dehydrogenase (LDH) release assay for necrosis, and mitochondrial activity was accessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction activity assay. It was found that ...
Green Tea Polyphenols are chemical compounds which are found naturally in tea, similar to flavonoids and tannins. This product can reduce the risk of d...
The chemotherapy agent irinotecan is highly effective against several types of cancer, but its use is limited due to severe intestinal toxicity. Green tea polyphenols (1 g per liter) used for seven days before and three days after treatment reduced the toxicity. Green tea polyphenols supplied orally protected against oxidation in our experimental model and could be one approach to reducing the risk of chemotherapy induced side effects in a clinical setting.. The chemotherapeutic agent irinotecan (IT) is highly effective against several types of cancer, although its use is limited due to severe intestinal toxicity. The aim of this study was to evaluate inflammatory and oxidative stress-related processes contributing to small intestinal mucosa damage and to determine the extent to which green tea polyphenols could ameliorate the detrimental effects induced by IT. In Expt. 1, mice were challenged intraperitoneally with IT or saline on 2 consecutive days. For time kinetic measurements, the ...
The Role of Polyphenols in Rosacea Treatment: A Systematic Review. The Journal of Alternative and Complementary Medicine. June 2017, ahead of print. Objectives: Various treatment options are available for the management of rosacea symptoms such as facial erythema, telangiectasia, papules and pustules, burning, stinging, and itching. Botanical therapies are commonly used to treat the symptoms. The objective of this review is to evaluate the use of polyphenols in rosacea treatment.. Design: PubMed, Embase, Biosis, Web of Knowledge, and Scopus databases were systematically searched for clinical studies evaluating polyphenols in the management of rosacea.. Results: Of 814 citations, 6 met the inclusion criteria. The studies evaluated licochalcone (n = 2), silymarin (n = 2), Crysanthellum indicum extract (n = 1), and quassia extract (n = 1). The studies only evaluated topical formations of stated polyphenols. Main results were summarized.. Conclusions: There is evidence that polyphenols may be ...
The aim of the study was to investigate the effect of selected polyphenols: gallic acid (GA) and epigallocatechin gallate (EGCG) on matrix metalloproteinase (MMP-2 and MMP-9) activity in multidrug resistant (MDR) human breast adenocarcinoma cells: MCF7/DOX cells and obtained recently in our laboratory MCF7/DOX500 cells by the permanent selection of MCF7/DOX cells with 500 nM doxorubicin (DOX). The activity of MMP-2 and MMP-9 and the effect of studied polyphenols on these matrix proteases were examined by gelatin zymography assays. We have found that the activity of MMP-2 and MMP-9 significantly increased in resistant MCF7/DOX and MCF7/DOX500 cells whereas they were not detected in sensitive MCF7 cells. It was also observed that GA (30, 60, 100 and 120 µM) and EGCG (5, 10 and 20 µM) caused a comparable concentration-dependent inhibition of MMP-2 and MMP-9 activity in MCF7/DOX and MCF7/DOX500 cells. Control experiments confirmed that examined compounds in these ranges of concentration did not ...
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Sun CL, Yuan JM, Lee MJ, Yang CS, Gao YT, Ross RK, Yu MC. USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA. [email protected] Experimental studies have shown that tea and tea polyphenols have anticarcinogenic properties. There have been no prospective investigations examining the relationship between tea polyphenols and cancer risk using validated biomarkers. In the present study, a nested case-control study design was used to investigate the association between prediagnostic urinary tea polyphenol markers and subsequent risk of gastric and esophageal cancers. One hundred and ninety incident cases of gastric cancer and 42 cases of esophageal cancer occurring in members of the Shanghai Cohort (18 244 men aged 45-64 years at recruitment with up to 12 years of follow-up) were compared with 772 cohort control subjects. The control subjects were individually matched to the index cases by age, ...
Since, it is estimated that 6000-8000 polyphenols exist in nature, a fraction have been isolated and studied, so our knowledge of these compounds, and how they interact with other antioxidants, such as those included in the antioxidant network that we discussed previously, is limited. Since all Polyphenol substances are subject to metabolic changes it is difficult to ascertain how these compounds affect our health specifically (Is it the polyphenols or the by product after metabolism that provides the benefit?). We know that Flavonoids alter Vitamin C transport and the function of Ascorbate oxidase,an enzyme that converts Vitamin C to a non vitamin form, but we dont know why, and if this relationship somehow enhances antioxidant function. It was always thought that polyphenols and other antioxidants simply scavenge free radicals as a form of protection against oxidative damage, but it is more the case of interaction of the polyphenolic compounds and their modification of redox status of the ...
The literature showed that Grape Products Containing Polyphenols (GPCP) had anti-oxidant activity. However, the effects of GPCP on different biomarkers of oxidative stress are still controversial. In this regard, this systematic review and meta-analysis aimed to evaluate the effect of Grape Products Containing Polyphenols (GPCP) intake on oxidative stress markers. PubMed, Scopus, Web of Science, and Google Scholar data bases were searched up to August 20, 2020. A random-effects model, weighted mean difference (WMD), and 95% confidence interval (CI) were applied for data analysis. Meta-analysis was conducted over 17 eligible RCTs with a total of 633 participants. The study registration number is CRD42019116696. A significant increase was observed in Total Antioxidant Capacity (TAC) (weighted mean difference (WMD) = 1.524 mmol/L, 95% confidence interval (CI): 0.83, 2.21). Intake of GPCP enhanced Superoxide Dismutase (SOD) (WMD = 0.450 mmol/L, 95% CI: 0.23, 0.66), TAC (WMD = 2.829 mmol/L, 95% CI: 0.13, 5
Research in stroke-prone spontaneously hypertensive rats demonstrated benefits from both black and green tea polyphenols. Oxidative stress is reportedly involved not only in cardiovascular disease but also in hypertension. Using continuous monitoring of blood pressure, both green tea polyphenols and black tea polyphenols significantly reduced both systolic and diastolic blood pressure compared with controls. These […]. ...
In recent decade, Hyperlipidemia related disorders like obesity, hypercholesterolemia and diabetes are considered as the leading killers for mankind. Fundamental nexus between nutrition and health diverting the consumers focus towards plant based natural products as a remedy against various metabolic syndrome. Considering this, present study was conducted to explicate the role of black tea polyphenols such as Theaflavins and thearubigins therapeutic potential to tackle targeted maladies especially oxidative stress related disorders like hypercholesterolemia and diabetes. The mandate of current investigation was to explore the hypoglycemic and hypocholestrolemic perspective of isolated theaflavin and thearubigins through a model feeding trial. For the purpose, theaflavin & thearubigins were isolated from black tea through solvent partition method and utilize to form three types of nutraceutical drinks (theaflavin, thearubigins & theaflavin + thearubigins based) alongside control to be further utilized in
Foods that are richly hued usually have high polyphenol counts - think grapes, berries, exotic spices - all deeply flavored and pigmented, thanks to the action of phenolic compounds. Polyphenols are also associated with bitter and astringent tastes found in foods such as coffee, tea, and certain tree fruits, like olives and pomegranates. * Polyphenols are a category…
Polyphenols Bolster Drug Effects in Ocular Hypertension Ocular Hypertension and Risk of Glaucoma Ocular hypertension is a leading risk factor for the development of primary open angle glaucoma (POAG), and is the only modifiable risk factor acknowledged at present. Its estimated that 4 to 7% of Americans over 40 years of age have ocular hypertension. The Ocular Hyper-tension Treatment Study (OHTS) clearly showed that lowering IOP is effective in delaying or preventing the onset of POAG in individuals with ocular hypertension. Recent results from a long-term study by the OHTS group indicates that those at high risk of POAG can benefit from early preventive treatment (1). Spurred by previous findings that a combination of polyphenols (anthocyanins and procyanidins) could improve IOP and blood flow in ocular hypertension, the same researchers recently compared the effects of those polyphenols alone and with latanoprost in ocular hypertensive patients with no signs of POAG (2). Study Design The ...
HESPERIDIN IN ORANGE JUICE IMPROVES HYPERTENSION AND ARTERIAL FUNCTION. Polyphenols are chemical compounds that are found in most of the plant-based foods that we commonly eat. As I discuss in detail in my new book, A Cancer Prevention Guide for the Human Race, some polyphenolic compounds, such as green tea flavonoids, soy-based isoflavones, quercetin, curcumin, and resveratrol, among other polyphenols, may possess important cancer prevention properties. There is also abundant research data suggesting that diets rich in certain natural dietary polyphenols may be associated with a decreased risk of cardiovascular disease, as well.. Hesperidin, which is a flavonoid polyphenol, is found in a variety of plant-based foods, including oranges, orange juice, and other citrus fruits. A newly published prospective, randomized, blinded clinical research study, which appears in the current issue of the American Journal of Clinical Nutrition, offers intriguing evidence that hesperidin may actually decrease ...
Epithelial-to-mesenchymal transition (EMT) in cancer cells is considered to be a prerequisite for acquiring invasive/migratory phenotype and subsequent metastasis. This study provides molecular evidence associated with the antimetastatic effect of black tea polyphenol extracts (BTE), which contain p …
Page contains details about multiwalled carbon nanotubes/tea polyphenols composite . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Limited available options for the treatment of CaP and its increasing incidence have spurred the search for novel preventive approaches for the management of this disease. Chemoprevention by the use of dietary agents or synthetic compounds could be one such strategy that may block the neoplastic inception or delay disease progression (4-6). Because CaP is typically diagnosed in men aged 50 years and older, even a slight delay in the onset and subsequent progression of the disease through the use of chemopreventive agent(s) could have important health benefits. Ideally, the efficacy of such chemopreventive agents should be verified in animal models that emulate human disease before recommending their use for humans. The most notable implication of our work is that oral infusion of a human-achievable dose of green tea results in significant inhibition in development and progression of CaP along with increased survival in an animal model that emulates human disease. These data, therefore, suggest ...
Green Tea (Camellia sinensis) extract is extremely rich in biologically active polyphenols, the most representative of which is Epigallocatechin 3-O gallate (EGCG), but it also contains other polyphenols belonging to the same chemical group. When topically applied on the skin in human clinical testing, green tea polyphenols have been reported to prevent UVB induced redness and DNA challenge.. ...
POLYPHENOLS CAN BE MORE EFFICIENT THAN VITAMIN E IN REDUCING OXIDATIVE PRESSURE. Vitamin E is not unique in its ability to neutralize free radicals. It belongs to a family of antioxidant compounds called polyphenols. Within this very diverse family, there are molecules that have a greater antioxidant capacity per gram than vitamin E.. Furthermore, some polyphenols have improved bioavailability. Thus, the improved activity and availability of some polyphenols result in a more effective antioxidant supply in livestock than vitamin E alone. STUDIES SHOW THAT FEED ADDITIVES CAN SAFELY REPLACE PART OF THE VITAMIN E REQUIREMENTS OF LIVESTOCK. Trouw Nutrition proved the efficacy of specifically selected polyphenols in both swine and poultry using a heat challenge model. Animals were fed either a negative control diet containing NRC-recommended levels of vitamin E, a positive control diet containing industry-standard levels of supplementation (above NRC), or a test diet in which the vitamin E above NRC ...
How Topical Extracts Have been Developed to Treat Skin Ailments. Green tea has also played a role in skin health by way of topical extracts. The polyphenols mentioned above act as antioxidants inside our body. They also have health benefits when topically applied. These polyphenols prevent inflammation and swelling, protect cartilage between bones, and lesson joint degeneration. Here are the 3 areas in which green tea can help your skin and organs grow and stay healthy.. 1) On-the-Surface Benefits: When applied topically, green tea can help prevent skin cancer by blocking toxic UV rays, and it works effectively in tandem with sunblock. Because of its rejuvenating properties as far as being an antioxidant and anti-inflammatory, it also makes sense that green tea is a great ointment for aging skin. Our trusty polyphenols are at work here too, slowing down the signs of aging by detoxifying.. 2) Healthy Cells: Growing evidence also shows that polyphenols in green tea extract can prevent many types ...
Common knowledge teaches that drinking a glass of red wine at dinner is good for your health.. Common knowledge also once taught that the earth was flat.. The polyphenols in red wine were once believed to increase HDL cholesterol and strengthen artery linings. Those findings were based on studies interpreted through the lens of the lipid hypothesis, the dubious low-fat, low-cholesterol theory now in contention by the medical community. One particular polyphenol - resveratrol - reduced inflammation and risk of diabetes in mice. However, the Mayo Clinic pointed out that a human would have to chug 1,000 liters of red wine a day to ingest the same amount administered to the mice.. One study even suggests that red wine can improve oral hygiene. The theory supposes that the antioxidant polyphenols in red wine could half the formation of bacteria in the biofilm on teeth.. Yet the mouth of the recreational wine drinker may turn the color of old bruises, ranging from pale yellow to deep purple.. ...
Dietitians often recommend green tea, red wine, nuts and fruits (especially berries) for their antioxidant boost! New research has discovered that many wholegrain breakfast cereals, and wholegrain snacks like popcorn and wholegrain crispbreads, have surprisingly large amounts of polyphenols, regarded as great antioxidants.. Researchers investigated the total polyphenol content of around 40 breakfast cereals and 20 snacks and found that wholegrain products have comparable antioxidants per gram to fruits and vegetables. The study revealed higher antioxidant levels than previous studies because the researchers analysed total polyphenol content rather than focusing on free antioxidants, which are not bound to sugar.. Ready to eat, cold breakfast cereals made with oats were found to have the highest antioxidants, followed by corn and wheat. Popcorn was at the top of the snack list, blitzing the competition with as much as five times as many antioxidants as the nearest rival.. Packed with vitamins, ...
Background: Few clinical studies have focused on the alcoholindependent cardiovascular effects of the phenolic compounds of red wine (RW). Objective: We aimed to evaluate the effects of ethanol and phenolic compounds of RW on the expression of inflammatory biomarkers related to atherosclerosis in subjects at high risk of cardiovascular disease. Design: Sixty-seven high-risk, male volunteers were included in a randomized, crossover consumption trial. After a washout period, all subjects received RW (30 g alcohol/d), the equivalent amount of dealcoholized red wine (DRW), or gin (30 g alcohol/d) for 4 wk. Before and after each intervention period, 7 cellular and 18 serum inflammatory biomarkers were evaluated. Results: Alcohol increased IL-10 and decreased macrophage-derived chemokine concentrations, whereas the phenolic compounds of RW decreased serum concentrations of intercellular adhesion molecule- 1, E-selectin, and IL-6 and inhibited the expression of lymphocyte function-associated antigen 1 ...
Do you believe in the power of food? Or that food can prevent disease and strengthen your heart? One bright red fruit comes to mind when discussing the impact of food on heart health. Pomegranates!. Pomegranates are high in potassium, vitamin C and polyphenols. Potassium helps your body maintain a healthy blood pressure. Vitamin C and polyphenols act as antioxidants and protect your body from stress by preventing inflammation. Antioxidants help your immune system fight off damaging free radicals.. We know that the nutritional components of pomegranate juice are beneficial, but what about studies conducted on regular consumption of pomegranates? The scientific research regarding pomegranates is limited, but the findings are promising. Pomegranate juice has been shown to decrease blood pressure in hypertensive individuals over a 2 week period1. Due to the antioxidants and polyphenols found in the fruit, regular consumption may reduce the risk of developing cardiovascular disease2.. Pomegranates ...
A phenolic acid is a sort of phytochemical known as a polyphenol. Phenolic acids are found in an assortment of plant-based nourishments such as the seeds and skins of products of the soil leaves of vegetables contain the most noteworthy concentration. Phenolic acids are promptly consumed through the dividers of your intestinal tract, and they might be valuable to your wellbeing since they fill in as cancer prevention agents that counteract cell harm because of free-radical oxidation responses. The Polyphenol phenolic acid supplements may likewise work as anti inflammatory in the human body. It strongly supports a role for polyphenols in the prevention of degenerative diseases, particularly cardiovascular diseases and cancers. The antioxidant properties of polyphenols have been widely studied, but it has become clear that the mechanisms of action of polyphenols go beyond the modulation of oxidative stress. Polyphenols are the most abundant antioxidants in the diet. Their total dietary intake ...
Baking blueberries could lead to changes their polyphenol content, and alter the potential health benefits of the superfood, according to new research.
The physicochemical properties of tea extracts are significantly affected by the extraction method. The aim of this study was to compare the effects of static and dynamic extractions on the concentrations of chemical components and taste quality of green tea extracts. Our results show that extraction of chemical components using static extraction follows a pseudo-second-order reaction, while that of dynamic extraction follows a first-order reaction. The concentrations of the solids, polyphenols, and free amino acids in green tea extract prepared by dynamic extraction were much higher, although the overall yields were not significantly different between the two extraction methods ...
We performed NMR binding experiments and docking studies with these polyphenols. In bidimensional heteronuclear NMR titration experiments (13) with 15N-labeled Bcl-xL, theaflavin, theaflavanin, and theaflavin-3′ gallate caused a wide broadening of the resonances (Fig. 3A) ⇓ . This result is typical of tight binding, although a high compound to protein ratio was needed, probably due to the limited solubility of the compounds at concentrations needed for NMR (500 μm). The observed broadening of the protein [15N,1H] resonances is characteristic of binding with intermediate exchange rates in the NMR time scale, representative of low- to submicromolar binders. Mapping of the observed changes in the NMR heteronuclear correlation spectra on titration with these compounds into the three-dimensional structure of Bcl-xL showed that many residues within and surrounding the BH3-binding pocket were affected by the compound binding, although the changes extended to a larger region surrounding this ...
Polyphenol interactions with both cellulose and collagen in the solid state have been studied by using chromatography on cellulose and by evaluating the hydrothermal stability of the polyphenol treated sheepskin collagen. Twenty-four polyphenolic compounds were studied, including seven glucose-based gallotannins, five polyalcohol-based gallotannins, and twelve ellagitannins. In the cellulose-polyphenols systems, the polyphenols affinity to cellulose is positively correlated with their molecular masses, the number of galloyl groups, and their hydrophobicity (logP). The polyphenol treatment increased the hydrothermal stability of collagen samples, and such effects are also positively correlated with the molecular masses, total number of galloyl groups and the hydrophobicity of polyphenols. Ellagitannins showed much weaker interactions with both biopolymers than gallotannins having similar molecular mass, the same number of galloyl groups, and the same number of phenolic hydroxyl groups. It is ...
4287 Prostate cancer (PCa) is the most common invasive malignancy and a major cause of cancer related deaths in male population in the USA. The existing treatment options have not been effective in the management of PCa, and therefore, novel approaches are urgently required. One approach to control this malignancy is through intervention by chemopreventive agents present in diet and beverages humans consume. Our published data in cell culture and animal studies supported by work from other laboratories as well as epidemiological observations and case control studies suggest that polyphenols present in tea plant Camelia sinensis possess PCa chemopreventive and possibly therapeutic effects. This study was designed to compare prostate tumor inhibitory effects of green tea polyphenols (GTP), water extract of black tea (BTE), and their major constituents epigallocatechin-3-gallate (EGCG) and theaflavins (TF), respectively, in athymic nude mice implanted with PCa cells. We chose CWR22Rν1 cells ...
Studies show that coffee is an exceptional transport mechanism for chlorogenics, which are absorbed into the blood stream and can improve, measured anti-oxidant levels. The trouble though is that many coffees have few chlorogenics or polyphenols.. Researchers are observing how polyphenols can cut the edge off these forces to improve workouts and speed recovery. Add high polyphenols to the caffeine already in coffee itself and you have the ideal training fuel.. I expected perhaps a 10 percent difference. What I found was truly staggering: Coffee beans with as much as 28,193 mg per kilogram of the key chlorogenics in a roasted coffee.. So much so, that they are called the new red wine for the hundreds of discreet flavors from hazelnut to strawberry jam and banana. Dark roasting can destroy up to 80 percent of CQAs, which are the main polyphenols in coffee; and Brew for maximum.. The Science Behind What Makes Coffee Healthy. Hundreds of journal articles3 have linked coffee drinking to decreases in ...
Imide functional polyphenols are prepared by reacting an excess of a phenol with an unsaturated diimide which is prepared by reacting an unsaturated polycycloaliphatic dicarboxylic acid anhydride with a diamine. These materials are useful in the preparation of castings, coatings, laminates and the like.
Response surface methodology (RSM) modelling was used for estimation of predictive total polyphenols content (TPC), total flavonoid content (TFC) and total tann
Pine bark contains complex polyphenols that are among the most potent of any plant. Pine polyphenols are powerful antioxidants, giving benefits to the cardiovascular system and the immune system. They are well known for supporting capillary health. Polyphenols are vigorous free radical scavengers that help the body reduce oxidative stress.. ...
Lavandula species are worldwide grown essential oil producing medicinal plants with considerable economic value. Beside volatile oil, lavender also contains different phenolic compounds which have been less widely studied till now. Cultivation of lavender has become widespread in Hungary in the recent years, however, growers have limit...ed knowledge on the productivity of cultivars available. In our research we were aimed to studying the antioxidant capacity and total polyphenol content of samples collected in two growing areas (Dörgicse and Szomód) from flowers of two L. angustifolia (Hidcote, Munstead) and two L. × intermedia (Grosso, Grappenhall) varieties, during the full blooming period of 2017. Antioxidant capacity of the samples was determined by FRAP assay (Benzie and Strain, 1996), while total polyphenol content (TPC) was measured by a modified method of Singleton and Rossi (1965). According to our results, varieties of L. × intermedia showed higher values of antioxidant ...
Dealcoholized wine retains the antioxidants found in regular wine, but almost no alcohol. Find out if dealcoholized wine is good for your health.
The Bottle: The researchers found evidence, that half of the bottled teas they sampled had extremely low levels of antioxidants or polyphenols. So low in fact, that they stated one would need to drink 20 bottles of the stuff to achieve the same health benefit as a single cup of home brewed tea.. But, hang on. Theres more.. I do want to point out that the researchers only sampled six bottles of tea. That means that three of those bottles had small amounts of polyphenols, or little to no health benefit. The other three had a healthy amount of antioxidants.. Here are the actual results: The six teas analyzed contained 81, 43, 40, 13, 4, and 3 milligrams (mg) of polyphenols per 16-ounce bottle.. The Brew: The average cup of home-brewed green or black tea contains about 50 to 150 mg of polyphenols.. Round One Results: As you can see from these results, more research is needed in order to firmly state that bottled teas contain little to no antioxidants. In fact, some bottled teas may well be just as ...
True polyphenols from the tannin and other WBSSH types are routinely biosynthesized in the natural sources from which they derive; their chemical syntheses (using standard bench organic chemical methods) were somewhat limited until the first decade of the new millennium because these syntheses involve challenging regioselectivity and stereoselectivity issues.[11] Early work focused on the achiral synthesis of phenolic-related components of polyphenols in the late 70s,[12] and the Nelson and Meyers synthesis of the permethyled derivative of the ubiquitous diphenic acid core of ellagitannins in 1994[13] followed by stereoselective synthesis of more complex permethylated structures such as a (+)-tellimagrandin II derivative by Lipshutz and coworkers in the same year,[14] and Itoh and coworkers synthesis of a permethylated pedunculagin with particular attention to axial symmetry issues in 1996.[15] The total synthesis of a fully unmasked polyphenol, that of the ellagitannin tellimagrandin I, ...
The World Health Organization has done a survey of the strengths and weaknesses of many kinds of drinks in a lot of country and has confirmed that tea is the best drink. According to contained tea polyphenols, caffeine and LPS which are nearly 300 kinds of components. It can regulate the physiological functions of the human body and play an important role for maintaining healthy and pharmacological effects.. Tea diet can prevent the increase of sterol within a human body and is a treatment of myocardial infarction. Tea polyphenols can also clear the excess free radicals within the body and to inhibit and kill pathogens. Moreover, tea is refreshing, can reduce fatigue and has antibacterial effect, etc. Tea can help uplifting ones energy and improve thinking and memory at the same time. It can eliminate fatigue and increase metabolism. It also helps maintaining the heart, blood vessels and gastrointestinal function as such normal function within the human body. It has a great help for the ...
Research on MRSA bacteria (superbugs) has shown that green tea polyphenols can improve the antibiotic oxycillin effectiveness by 8 to 128-fold.
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Wine polyphenols vary with age and variety (Polyphenols on www.guideduvin.com) (in French) ... Natural phenols and polyphenols from cork stoppers[edit]. Extracted cork closure inscribed with "Bottled at origin" in Spanish ... Grape polyphenols[edit]. Vitis vinifera produces many phenolic compounds. There is a varietal effect on the relative ... The phenolic content in wine refers to the phenolic compounds-natural phenol and polyphenols-in wine, which include a large ...
Polyphenols[edit]. The phenolic composition analysis of vinegar shows the presence of numerous flavonoids, phenolic acids and ...
Polyphenols[edit]. In addition to beta-carbolines, caapi is known to contain proanthocyanidins, epicatechin and procyanidin B2 ...
Further information: Health effects of polyphenols. Polyphenols of several classes are widespread in plants, having diverse ... Polyphenols include phytoestrogens (top and middle), mimics of animal estrogen (bottom).[71] ... containing polyphenols called punicalagins, is used as a medicine.[70] ... "The High Polyphenol Content of Grapevine Cultivar Tannat Berries Is Conferred Primarily by Genes That Are Not Shared with the ...
Polyphenols[edit]. Canned capers contain polyphenols, including the flavonoids quercetin (173 mg per 100 g) and kaempferol (131 ...
Polyphenols[edit]. Non-glandular trichomes in the genus Cistus were found to contain presences of ellagitannins, glycosides, ... It contains non-glandular, stellate and dendritic trichomes that have the ability to synthesize and store polyphenols that both ...
Polyphenols[edit]. Vinegar contains numerous flavonoids, phenolic acids, and aldehydes,[3] which vary in content depending on ...
Polyphenol compounds may interact with volatiles and contribute to the aromas in wine.[48] Although wine polyphenols are ... Wine polyphenols vary with age and variety (Polyphenols on www.guideduvin.com) (in French) ... Natural phenols and polyphenols from cork stoppers[edit]. Extracted cork closure inscribed with "Bottled at origin" in Spanish ... Grape polyphenols[edit]. Vitis vinifera produces many phenolic compounds. There is a varietal effect on the relative ...
Harborne, JB (January 1962). "Plant polyphenols. 5. Occurrence of azalein and related pigments in flowers of Plumbago and ...
Quideau, Stéphane (22 September 2009). "Why bother with Polyphenols". Groupe Polyphenols. Archived from the original on 10 ... Plant Polyphenols: 259-280. doi:10.1007/978-1-4615-3476-1_15. ISBN 978-1-4613-6540-2. Plant Polyphenols: Synthesis, Properties ... The most abundant polyphenols are the condensed tannins, found in virtually all families of plants, and comprising up to 50% of ... Polyphenol Ferrell, Katie E.; Thorington, Richard W. (2006). Squirrels: the animal answer guide. Baltimore: Johns Hopkins ...
Liaison-Groupe Polyphenols. 14: 248-257. Biology portal v t e. ...
Primulin Yellow on chemicalregister.com J. B. Harborne; H. S. A. Sherratt (1961). "Plant Polyphenols: 3. Flavonoids in ...
Harborne, J.B. (1962). "Plant polyphenols: 5. Occurrence of azalein and related pigments in flowers of Plumbago and Rhododendro ...
Not like controlled test tube conditions, the fate of polyphenols in vivo shows they are poorly conserved (less than 5%), with ... The increase in antioxidant capacity of blood seen after the consumption of polyphenol-rich (ORAC-rich) foods is not caused ... As interpreted by the Linus Pauling Institute, EFSA and the USDA, dietary polyphenols have little or no direct antioxidant food ... Arts IC, Hollman PC (2005). "Polyphenols and disease risk in epidemiologic studies". Am. J. Clin. Nutr. 81 (1 Suppl): 317S-325S ...
Gross P (1 March 2009). "New Roles for Polyphenols. A 3-Part Report on Current Regulations and the State of Science". ... including a diverse class with non-nutrient status called polyphenols, which remain poorly understood as of 2017. ... whereas those without nutrient status are diverse polyphenols, flavonoids, resveratrol, and lignans - often claimed to have ...
Seasonal variation in polyphenol content of Ascophyllum nodosum (L.) Le Jol. And Fucus vesiculosus (L.)". Journal of ... Ragan, Mark A.; Glombitza, K.-W. (1986). "Phlorotannins, brown algal polyphenols". Prog. Phycol. Res. 4: 129-241. Schoenwaelder ... "Chelation of divalent metal ions by brown algal polyphenols". Marine Chemistry. 7 (3): 265. doi:10.1016/0304-4203(79)90043-4. ...
There is a risk that polyphenol oxidase (PPO) degrades the phenolic content of the sample therefore there is a need to use PPO ... Gutfinger, T. (1981). "Polyphenols in olive oils". Journal of the American Oil Chemists' Society. 58 (11): 966-8. doi:10.1007/ ... F. Favaron, M. Lucchetta, S. Odorizzi, A. T. Pais da Cunha and L. Sella (2009). "The role of grape polyphenols on trans- ... The phenolic unit can be found dimerized or further polymerized, creating a new class of polyphenol. For example, ellagic acid ...
With the three phases oil decanter, a portion of the oil polyphenols is washed out due to the higher quantity of added water ( ... "Polyphenols in olive oils". T. Gutfinger, Journal of the American Oil Chemists' Society, Volume 58, Number 11, 966-968, doi: ... In addition, the chemical content of the polyphenols, antioxidants, and vitamins present in the oil is reduced by higher ... Advantages Higher polyphenol content of oil Low temperature method Automated Low labor Oil/water separation step is not needed ...
Gross, P (2009). "New Roles for Polyphenols. A 3-Part report on Current Regulations & the State of Science". Nutraceuticals ...
Dried raisins are high in polyphenol count.[citation needed] Red wine is high in total polyphenol count which supplies ... Not like controlled test tube conditions, the fate of flavones or polyphenols in vivo shows they are poorly absorbed and poorly ... The increase in antioxidant capacity of blood seen after the consumption of polyphenol-rich (ORAC-rich) foods is not caused ... Flavonoids, a subset of polyphenol antioxidants, are present in many berries, as well as in coffee and tea. Flavones: Apigenin ...
"Polyphenols in olive oils". T. Gutfinger, Journal of the American Oil Chemists' Society, Volume 58, Number 11, 966-968, doi: ... Unfiltered olive oil initially has higher levels of phenolics that form a complex polyphenol-protein complex. This complex ...
Polyphenols[1][2] (noun, pronunciation of the singular /ˌpɒliˈfiːnoʊl/[3] or /ˌpɒliˈfiːnɒl/[4][5]; also known as ... a b Polyphenol on www.merriam-webster.com online dictionary. *^ "Polyphenol definition and meaning , Collins English Dictionary ... Polyphenols are also found in animals. In arthropods such as insects[44] and crustaceans[45] polyphenols play a role in ... Hence, many larger polyphenols are biosynthesized in-situ from smaller polyphenols to nonhydrolyzable tannins and remain ...
PolyphenolsEdit. Further information: Polyphenol. Polyphenols of several classes are widespread in plants. They include the ... Polyphenols include phytoestrogens (top and middle), effective mimics of animal estrogen (bottom).[26] ... Halliwell, B. (2007). "Dietary polyphenols: Good, bad, or indifferent for your health?". Cardiovascular Research. 73 (2): 341- ... while polyphenol extracts from plant materials such as grape seeds are sold for their potential health benefits They have been ...
PolyphenolsEdit. Vinegar contains numerous flavonoids, phenolic acids, and aldehydes,[3] which vary in content depending on the ...
Iwashina, T.; Ootani, S. (1995). "Polyphenols in Iris setosa var. canadensis and their chemotaxonomic comparisons with three ...
Plant Polyphenols: Synthesis, Properties, Significance. Springer Science & Business Media. p. 885. ISBN 978-0-306-44252-0. ...
Plant Polyphenols: Synthesis, Properties, Significance. Richard W. Hemingway, Peter E. Laks, Susan J. Branham (page 263) "28 ... Firstly, in the cell vacuoles where it is complexed with polyphenols. This caffeine probably is released into the mouth parts ... precipitates polyphenols and tannins. This property can be used in a quantitation method. Around thirty plant species are known ... and polyphenols that can form insoluble complexes with caffeine. Products containing caffeine include coffee, tea, soft drinks ...
Caffeine may not be the important component; polyphenols may be more important. Drinking two or more cups of coffee a day is ...
Polyphenols in Cereals and Legumes (1980) and Science, Agriculture, and Food Security (1995) are two other notable books ... Joseph H. Hulse (1980). Polyphenols in Cereals and Legumes. International Development Research Centre. p. 72. ISBN ... Joseph H. Hulse (1980). Polyphenols in Cereals and Legumes. International Development Research Centre. p. 72. ISBN ...
Polyphenols: ≥ 100 p.p.m. Italian products with protected designation of origin Olive oil regulation and adulteration Olive oil ...
This MNT Knowledge Center article explains the benefits of polyphenols and which foods contain them. It also looks at the ... Polyphenols are compounds found in plants, including flavonoids and phenolic acid, that greatly benefit the human body and help ... High-polyphenol foods. Share on Pinterest. Various herbs and spices contain polyphenols, including star anise, peppermint, and ... Polyphenols are a category of chemicals that naturally occur in plants. There are more than 500 unique polyphenols. ...
polyphenols. Decay rate and substrate quality of fine roots and foliage of two tropical tree species in the Luquillo ...
Polyphenol content as key-indicator of plant litter quality and palatability for macro-decomposers. Julia Seeber, Alexander ... In the proposed study we want to analyse the polyphenol contents of fresh plant material and litter of different stages ( ... An important prerequisite for studies dealing with these interactions are the polyphenol contents of various alpine plant ... These two assays are well accepted as the two most frequently used polyphenol measurements. ...
The health benefits of pomegranate have long been associated with the high content of antioxidant polyphenols and Pomella ... supported 20 week clinical trial investigated properties of heart-friendly Mediterranean diet olive and pomegranate polyphenols ...
How Polyphenols enhance probiotic benefits BerryPharma® - the Expert in Berry Extracts , 17-Oct-2017 , Research Study ... Kiwifruit polyphenols may offer prebiotic potential, protect against leaky gut. *. Study: Blackcurrant extract improves ... Acute benefits of polyphenols for Sports Nutrition Fytexia® , 20-Sep-2017 , Clinical Study ... This white paper demonstrates the added value polyphenols can bring to sports nutrition formulas by providing acute clinically ...
How Polyphenols enhance probiotic benefits BerryPharma® - the Expert in Berry Extracts , 17-Oct-2017 , Research Study ... Acute benefits of polyphenols for Sports Nutrition Fytexia® , 20-Sep-2017 , Clinical Study ... This white paper demonstrates the added value polyphenols can bring to sports nutrition formulas by providing acute clinically ... Polyphenol & omega-3 supplement may boost brain health in young kids: Study ...
ENI)Polyphenol-C: a new premium vitamin C for today provides wide-spectrum berry polyphenols ... The health benefits of pomegranate have long been associated with the high content of antioxidant polyphenols and Pomella ... supported 20 week clinical trial investigated properties of heart-friendly Mediterranean diet olive and pomegranate polyphenols ...
The students of the main group ingested the alcohol-free dietary grape polyphenol concentrate Enoant for 20 days at a daily ... Brunner E.Y., Mizin V.I. (2013) Grape Polyphenols Attenuate Psychological Stress. In: Pierce G., Mizin V., Omelchenko A. (eds) ... Mizin VI., Ogay YA (2011) Catastrophe medicine and environmental security: the dietary grape polyphenol concentrate enoant as ... Biologically active properties of polyphenols of the grape and wine). Magarach Viticulture Winemaking 4:25-26Google Scholar ...
Glycoside Polyphenol Flavonol Rhamnose Phloroglucinol S. M. Kirov Kazakh State University, Alma-Ata. Translated from Khimiya ...
This review summarizes the effect of polyphenols on inflammation and cancer; avenanthramides, a unique polyphenol from oats, ... Dietary polyphenols have been shown to have anti-inflammatory and anticancer activity partially through inhibition of NF-kappa ... Dietary polyphenols, inflammation, and cancer.. Guo W1, Kong E, Meydani M. ...
Further, these two polyphenols inhibit growth of pancreatic cancer cell line, Panc02, in vitro. Results suggest that mechanisms ... Resveratrol and quercetin are polyphenols abundant in frequently consumed fruits, vegetables, and red wine. They have many ... Pancreatic Cancer Suppression by Natural Polyphenols. Guoliang Cui. ,1 Yuebo Zhang. ,1 Cindy Liu. ,2 Sheri Skinner. ,2 and Ying ... Pancreatic Cancer Suppression by Natural Polyphenols,. Scholarly Research Exchange,. vol. 2008. ,. Article ID 540872. ,. 6. ...
In the first study, some of the men drank varying amounts of blueberry polyphenols, ranging from the equivalent of 240 grams (3 ... The researchers measured changes in FMD at 0, 1, 2, 4 and 6 hours after the men drank the blueberry polyphenols. They found ... The beneficial effects correlated with levels of blueberry polyphenol metabolites in the blood plasma. In other words, as the ... A second study was conducted to investigate the dose of blueberry polyphenols needed to see beneficial effects. The researchers ...
Topic: Health Related: antioxidant, green tea, matcha, polyphenols. Health Benefits of Pomegranate Juice. August 3, 2006. by ... Topic: Nutrition 101 Related: alcohol, antioxidant, beverages, polyphenols. Green Tea: Health Benefits and How-To. April 1, ... Topic: Health Related: anthocyanins, antioxidant, cholesterol, diabetes, polyphenols, pomegranate, tannins. Primary Sidebar. ... Topic: Health, Nutrition 101 Related: antioxidant, cancer diet, green tea, heart smart, matcha, polyphenols, tea ...
Polyphenols are one family of plant compounds that are abundant in coffee as well as red wine, fruits and fruit juices, tea, ... Polyphenols are a rich source of dietary antioxidants. On average, people consume about 10 times more polyphenols than they do ... Polyphenols are one family of plant compounds that are abundant in coffee as well as red wine, fruits and fruit juices, tea, ... The properties of polyphenols have only been under investigation since the 1990s, but there is increasing evidence that they ...
Polyphenols are a hot topic among functional food proponents due to increasing evidence that they can impact your health in ... Polyphenols can decrease your risk of arterial lesions, which lead to increased risk of heart disease. Polyphenols may also ... A number of polyphenol supplements are currently popular with consumers. Consult your doctor before taking polyphenol ... technologies that bond polyphenols to molecules of phophatidylcholine help to make polyphenols more readily absorbable through ...
The term polyphenol is not well defined, but it is generally agreed that they are natural products "having a polyphenol ... Polyphenols are also found in animals. In arthropods such as insects and crustaceans polyphenols play a role in epicuticle ... The most abundant polyphenols are the condensed tannins, found in virtually all families of plants. Larger polyphenols are ... Hence, many larger polyphenols are biosynthesized in-situ from smaller polyphenols to non-hydrolyzable tannins and remain ...
Polyphenols are plant secondary metabolites derived from the phenylpropanoid and polyketide biosynthetic pathways that feature ... Plant polyphenols are known to interact with proteins in a nonspecific manner, but some plant polyphenols can engage proteins ... 1985) Polyphenol interactions. Part 1. Introduction: some observations on the reversible complexation of polyphenols with ... All vegetable tannins are polyphenols, but plant polyphenols are not all capable of tanning actions. ...
Popcorn is loaded with more antioxidants called polyphenols than vegetables and fruit, researchers from the University of ... Polyphenols amounted to up to 114mg per sweet corn serving. *Polyphenols amounted to up to 160mg per fruit serving (average of ... Vinson and team set out to determine what the total polyphenols in popcorn are.. The researchers found that polyphenols were ... Although low concentrations of free polyphenols had been found in popcorn in previous studies, its total polyphenols content ...
Find patient medical information for APPLE POLYPHENOLS on WebMD including its uses, effectiveness, side effects and safety, ... APPLE POLYPHENOLS Overview Information. Apple polyphenols are chemicals found in apples.. Apple polyphenols are used for ... APPLE POLYPHENOLS Side Effects & Safety. When taken by mouth: Apple polyphenols are POSSIBLY SAFE when taken short-term. Taking ... APPLE POLYPHENOLS Dosing. The appropriate dose of apple polyphenols depends on several factors such as the users age, health, ...
Polyphenol oxidase (PPO; also polyphenol oxidase i, chloroplastic), an enzyme involved in fruit browning, is a tetramer that ... Polyphenol oxidase is an enzyme found throughout the plant and animal kingdoms, including most fruits and vegetables. PPO has ... Plants make use of polyphenol oxidase as one in a suite of chemical defences against parasites. Tyrosine is a key compound of ... In insects, cuticular polyphenol oxidases are present and their products are responsible for desiccation tolerance. Grape ...
The lay press often heralds polyphenols as panacea for all sorts of diseases. The rationale is that their antioxidant activity ... Polyphenols and human health: a prospectus Crit Rev Food Sci Nutr. 2011 Jul;51(6):524-46. doi: 10.1080/10408391003698677. ... The lay press often heralds polyphenols as panacea for all sorts of diseases. The rationale is that their antioxidant activity ... We summarize the recent findings concerning the effects of polyphenols on human health, analyze the current limitations at ...
Tea polyphenols are chemical compounds like flavonoids and tannins that are found naturally in tea. The benefits of polyphenols ... Other polyphenols can also change the color of the tea, making it more reddish or brown depending on how it is handled, and the ... Tea polyphenols are chemical compounds, such as flavanoids and tannins, found naturally in tea. Depending on how the tea is ... Tea polyphenols are known to have some amazing properties that are believed to fight cancer depending on how much of this key ...
Higher levels of healthy polyphenols were found in ketchups made from organically grown tomatoes than from conventional … ...
Purchase Polyphenols: Mechanisms of Action in Human Health and Disease - 2nd Edition. Print Book & E-Book. ISBN 9780128130063, ... Chocolate/Cocoa Polyphenols and Oxidative Stress. JUDITH E ALLGROVE, GLEN DAVISON. 17. An Overview of Dietary Polyphenols and ... Polyphenols: Mechanisms of Action in Human Health and Disease, Second Edition describes the mechanisms of polyphenol ... Polyphenols: Mechanisms of Action in Human Health and Disease 2nd Edition. Write a review ...
G. R. Beecher, B. A. Warden, and H. Merken, "Analysis of tea polyphenols," Proceedings of the Society for Experimental Biology ... Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases. Jun-ichi Suzuki,1 Mitsuaki Isobe,2 Ryuichi ... Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, ... R. Benelli, R. Vene, D. Bisacchi, S. Garbisa, and A. Albini, "Anti-invasive effects of green tea polyphenol epigallocatechin-3- ...
Polyphenols from Ginkgo biloba. Fadi QADAN 1,* , Adolf NAHRSTEDT 2, Mathias SCHMIDT 3 and Kenza MANSOOR 4 ... QADAN, F.; NAHRSTEDT, A.; SCHMIDT, M.; MANSOOR, K. Polyphenols from Ginkgo biloba. Sci. Pharm. 2010, 78, 897-908. ... QADAN F, NAHRSTEDT A, SCHMIDT M, MANSOOR K. Polyphenols from Ginkgo biloba. Scientia Pharmaceutica. 2010; 78(4):897-908. ...
Experimental: Polyphenols 9 weeks of supplementation with polyphenols(D56) and during the last week supplementation with ... Polyphenols and Insulin Resistance (POLYOXRESIST). The safety and scientific validity of this study is the responsibility of ... Drug: polyphenol 2 capsules of 0.5 gram to be taken at the beginning of breakfast and dinner (2g/day) fructose : dose of 3 g/kg ... INFLUENCE OF POLYPHENOLS ON OXIDATIVE STRESS IN HEALTHY INDIVIDUALS WITH HIGH METABOLISM RISK: RELATIONSHIP WITH THE MECHANISMS ...
Focusing on non-extractable polyphenols and carotenoids that are present in the diet, this book will improve our knowledge of ... Polyphenols and carotenoids are abundant in fruits, vegetables, herbs and spices, and beverages, such as tea, cocoa and wine ... The Story of the Introduction of Non-extractable Polyphenols into Polyphenol Research: Origin, Development and Perspectives. F ... Analysis of Non-extractable Polyphenols (NEPP). T. Wu, N. N. M. Phuong, J. Van Camp, G. Smagghe, T. T. Le and K. Raes ...
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects ... Modulation of neurotrophic signaling pathways by polyphenols Drug Des Devel Ther. 2015 Dec 21;10:23-42. doi: 10.2147/DDDT. ... Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects ... Several polyphenols including flavonoids such as baicalein, daidzein, luteolin, and nobiletin as well as nonflavonoid ...
This study is the first to show a role for T cells in polyphenol-mediated protection against an autoimmune disease and could ... Results showed that mice treated orally with apple polyphenols were protected from colitis. Importantly, scientists also found ... In mice lacking T cells, apple polyphenols were unable to protect against colitis or suppress proinflammatory cytokine ... and the other group of mice was given an oral dose of apple polyphenols every day during the course of the disease. ...
  • A study in animals looked at the effect of green tea polyphenols on measures of inflammation after exercise. (medicalnewstoday.com)
  • Green tea polyphenols inhibit the growth of bacteria. (wisegeek.com)
  • In this article, effects of green tea polyphenols (GTP) and black tea polyphenols (BTP) on the molecules and events involved in metastasis are discussed in detail. (bioportfolio.com)
  • Green Tea Polyphenols: Nutraceuticals of Modern Life presents a collection of global findings on the numerous health benefits of green tea polyphenols, confirming their position as healthy functional ingredients. (routledge.com)
  • It then describes the chemical composition and biochemical and physicochemical characteristics, followed by a discussion of the properties of green tea polyphenols, including metabolism, bioavailability, and safety. (routledge.com)
  • The subsequent chapters deal with the numerous health benefits associated with consumption of green tea polyphenols. (routledge.com)
  • It also examines food and nonfood applications of green tea polyphenols, such as extracts, supplements, and skin and hair cosmetic products, demonstrating both therapeutic and functional health benefits. (routledge.com)
  • This book brings together a wide array of data on green tea polyphenols, providing a greater understanding of them and insight into their effects on human health, and their applications and commercial potential. (routledge.com)
  • and Case Western Reserve University, Cleveland, Ohio, documented the role of green tea polyphenols (GTP) in modulating the insulin-like growth factor-1 (IGF-1)-driven molecular pathway in prostate tumor cells in a mouse model for human prostate cancer. (eurekalert.org)
  • The green tea polyphenols contributed to minimizing tumor development by governing the amount of vascular endothelial growth factor (VEGF) in the serum of the prostate cancer mouse model. (eurekalert.org)
  • This review article summarizes the photoprotective effects of some selected polyphenols, such as green tea polyphenols, grape seed proanthocyanidins, resveratrol, silymarin and genistein, on UV-induced skin inflammation, oxidative stress and DNA damage, etc., with a focus on mechanisms underlying the photoprotective effects of these polyphenols. (nih.gov)
  • A recent paper 1 reports that in 4-5-week-old male ICR rats fed a regular chow diet supplemented with 0.2% by weight of green tea polyphenols for 7 days, the animals had improved memory in the step-through latency test after pretreatment with scopolamine. (life-enhancement.com)
  • The authors found that "Chronic administration of TP [green tea polyphenols] significantly increased latency time. (life-enhancement.com)
  • This may be yet another mechanism for beneficial effects from green tea polyphenols. (life-enhancement.com)
  • The students of the main group ingested the alcohol-free dietary grape polyphenol concentrate Enoant for 20 days at a daily dose of 35 ml. (springer.com)
  • Dietary polyphenols, inflammation, and cancer. (nih.gov)
  • Dietary polyphenols have been shown to have anti-inflammatory and anticancer activity partially through inhibition of NF-kappa B activation. (nih.gov)
  • Polyphenols are a rich source of dietary antioxidants. (livestrong.com)
  • Hundreds of polyphenol compounds have been discovered in dietary sources, according to 'Critical Reviews in Food Science and Nutrition. (livestrong.com)
  • Focusing on non-extractable polyphenols and carotenoids that are present in the diet, this book will improve our knowledge of dietary intakes and physiological properties ensuring a better understanding of their potential health effects. (rsc.org)
  • Metabolic Profiling of Dietary Polyphenols and Methylxanthines in Normal and Malignant Mammary Tissues from Breast Cancer Patients. (bioportfolio.com)
  • Dietary polyphenols may protect against breast cancer. (bioportfolio.com)
  • The aim of the Polyphenol Intervention Trial (PPhIT) was to determine if increasing overall polyphenol dietary intake results in improved microvascular function, measured by forearm blood flow (FBF) responses to acetylcholine (Ach), an endothelium-dependent vasodilator ( see page 1371 ). (bmj.com)
  • It is thought that dietary compounds including polyphenols present in plant foods contribute to their protective effect. (eufic.org)
  • However, due to the fact that polyphenols are not an absolute requirement in our diet, and that their health benefits in humans are still debated, there is currently no official dietary recommendation for polyphenol intake. (eufic.org)
  • A wide variety of polyphenols or phytochemicals, most of which are dietary supplements, have been reported to possess substantial skin photoprotective effects. (nih.gov)
  • The main source of polyphenols is dietary, since they are found in a wide array of phytochemical -bearing foods. (wikipedia.org)
  • [1] There is no substantial evidence, however, that dietary polyphenols have an antioxidant effect in vivo. (wikipedia.org)
  • Consuming dietary polyphenols have been evaluated for biological activity in vitro, but there is no evidence from high-quality clinical research as of 2018 that they have effects in vivo. (wikipedia.org)
  • Polyphenols, dietary substances from vegetables, fruits and green tea, bring about a change in the energy metabolism. (innovations-report.com)
  • It is well known that cocoa and dark chocolate possess polyphenols as major constituents whose dietary consumption has been associated to beneficial effects. (frontiersin.org)
  • Mostly, fruits, vegetables, and cereals are considered as major sources of dietary polyphenols, which human beings assume with food. (frontiersin.org)
  • Taken together, all these are general consideration on dietary polyphenols effects and for more details on their chemical structure and functions, readers are referred to Ref. ( 7 , 8 ). (frontiersin.org)
  • whilst] some dietary phenolic compounds, mainly polyphenols, also have been shown to affect human platelet function in vitro and in vivo, said de Roos and her colleagues. (anabolicminds.com)
  • 3 Very recently, these biological properties of polyphenols have been reported after in vivo treatment with either red wine or other dietary sources, such as grape juice. (ahajournals.org)
  • We will obtain urgently-needed data to permit a risk-benefit analysis of the significance of dietary polyphenols in the modulation of colon cancer, and whether there might be justification for dietary modification, the production of supplements and novel foods. (europa.eu)
  • The gut microbiota also manages the bioaccessibility of phenolic metabolites from dietary polyphenols whose multiple beneficial properties have known therapeutic efficacy against depression. (frontiersin.org)
  • Although several potential therapeutic mechanisms of dietary polyphenols toward establishing cognitive resilience to neuropsychiatric disorders have been established, only a handful of studies have systematically identified how the interaction of the gut microbiota with dietary polyphenols can synergistically alleviate the biological signatures of depression. (frontiersin.org)
  • The current review investigates several of these potential mechanisms and how synbiotics, that combine probiotics with dietary polyphenols, may provide a novel therapeutic strategy for depression. (frontiersin.org)
  • Since 2011, AIST has been collaborating with Nisshin Seifun Group Inc. and Oriental Yeast to study novel functionalities of wheat polyphenols contained in whole-wheat flour and wheat bran, dietary ingredients that can be consumed on a regular basis. (medicalxpress.com)
  • Potential Mechanisms of Action of Polyphenols in Diabetes Risk The hypoglycemic effects of dietary polyphenolic compounds may be related to inhibition of carbohydrate digestion by. (syromonoed.com)
  • In contrast, dietary polyphenols have been suggested to exert both beneficial and detrimental effects on glucose and insulin metabolism. (cambridge.org)
  • Recently, we reported that a polyphenol-rich insoluble dietary fibre preparation from carob pulp (carob fibre) resulted in lower postprandial acylated ghrelin levels after a liquid meal challenge test compared with a control meal without supplementation. (cambridge.org)
  • However, the bioavailability of many polyphenols is poor and it is unclear whether sufficient quantities can be obtained by dietary means to exert protective effects. (wiley.com)
  • To assess whether other classes of dietary polyphenols, or their metabolites, also beneficially affect platelet function requires more well-controlled intervention studies as well as the adoption of more uniform methods to assess platelet aggregation and activation. (wiley.com)
  • Polyphenol intake was estimated at baseline using validated center/country-specific dietary questionnaires and the Phenol-Explorer database. (kb.se)
  • Polyphenols are one family of plant compounds that are abundant in coffee as well as red wine, fruits and fruit juices, tea, vegetables, chocolate and legumes. (livestrong.com)
  • Polyphenols are antioxidant compounds derived from plants. (livestrong.com)
  • Such highly impacting physicochemical properties for compounds that are present in numerous plant‐derived foods and beverages continue to date to fuel multidisciplinary investigations on the role of polyphenols in plant biochemistry, physiology and ecology, and on their possible effects and applications in nutrition, food quality and preservation, food supplements, diseases prevention and curation, as well as in cosmetics and new materials. (els.net)
  • Tea polyphenols are chemical compounds, such as flavanoids and tannins , found naturally in tea. (wisegeek.com)
  • As with many natural compounds that appear to have health benefits, it is difficult to isolate and study these polyphenols on their own, and some researchers have suggested that their actions in the body may actually be the result of several compounds working together. (wisegeek.com)
  • Other polyphenols can also change the color of the tea, making it more reddish or brown depending on how it is handled, and the subtle and distinctive flavors of well-processed teas are due in part to these compounds. (wisegeek.com)
  • Polyphenols (/ˌpɒliˈfiːnoʊl, -nɒl/) are a large family of naturally occurring organic compounds characterized by multiples of phenol units. (wikipedia.org)
  • Ellagic acid (M.W. 302, right), a molecule at the core of naturally occurring phenolic compounds of varying sizes, is itself not a polyphenol by the WBSSH definition, but is by the Quideau definition. (wikipedia.org)
  • These residues contain substantial amounts of high value-added products such as carbohydrates, proteins, pectins and bioactive compounds like polyphenols 6 . (nature.com)
  • Grapes contain certain polyphenol compounds, although none has been shown to be an antioxidant in vivo. (wikipedia.org)
  • The content of polyphenol compounds such as total phenols, total flavonoids, condensed tannins and phenolic acids of the sour guava fruits (Psidium araca) was determined. (ebscohost.com)
  • Walnuts are loaded with antioxidant polyphenols, compounds that interact with free radicals to stabilize them and prevent them from wreaking havoc on our cells. (nydailynews.com)
  • The water added during the malaxation in the three-phase processing, the researchers explained, partly strips the oil of its beneficial compounds by sweeping away some of the polyphenols with waste water. (oliveoiltimes.com)
  • Polyphenols are a large class of chemical compounds synthesized by fruits, vegetables, teas, cocoa and other plants that possess certain health benefits. (syromonoed.com)
  • Polyphenols is a water-soluble compounds and type of phytochemical with structural presentation of (high density of phenolic substructure) large multiples of phenol structural units. (worldwidehealth.com)
  • As long suspected, the presence or absence of non-volatile compounds (such as polyphenols) play an important role on our ability to "smell" volatile compounds (like the ones involved in Sauvignon blanc aroma). (ucdavis.edu)
  • This review focuses on the anti-hypertensive action of quercetin, a flavonoid, which is one of the polyphenols characterized as the compounds containing large multiples of phenol structural units, by varying the values of various blood pressure regulatory factors, such as vascular compliance, peripheral vascular resistance, and total blood volume via anti-inflammatory and anti-oxidant actions. (wellnessresources.com)
  • Many of the health benefits associated with polyphenols may be related to their role as antioxidants . (medicalnewstoday.com)
  • Plant polyphenols can act either as protective antioxidants or toxic prooxidants, depending on their specific chemical structure and set of conditions under which they are used. (els.net)
  • Popcorn is loaded with more antioxidants called polyphenols than vegetables and fruit, researchers from the University of Scranton, Pennsylvania, revealed in the 243rd National Meeting & Exposition of the American Chemical Society, in San Diego, California, USA. (medicalnewstoday.com)
  • Apple polyphenols are antioxidants. (webmd.com)
  • Polyphenols are antioxidants, which means that they can reduce the risk of developing coronary artery disease and a number of other health problems. (wisegeek.com)
  • Polyphenols are reactive species toward oxidation, hence their description as antioxidants in vitro. (wikipedia.org)
  • Findings published in the Journal of Leukocyte Biology (https://www.jleukbio.org), confirm oral ingestion of apple polyphenols (antioxidants found in apple peels) can suppress T cell activation to prevent colitis in mice. (medindia.net)
  • Besides, proving that polyphenols also act as antioxidants in the human body is not an easy task as polyphenols undergo changes when they are ingested. (eufic.org)
  • Many epidemiologic studies suggest protection against CVD from moderate intake of alcoholic beverages, especially those rich in antioxidants, such as red wine, which is high in polyphenols (RWPs). (eurekalert.org)
  • This study examined whether intake of red wine polyphenols (RWPs), a rich source of natural antioxidants, prevents ageing-related impairment of vascular function and physical exercise capacity. (eurekalert.org)
  • Previous investigations have shown tea polyphenols also possess antioxidants, natural enzyme inhibitions, and antibacterial properties. (thermofisher.com)
  • Jarrow Bilberry plus Grapeskin Polyphenols (280 mg) - 120 caps contain a synergistic mix of standardized flavonoid antioxidants. (astronutrition.com)
  • Health benefits from polyphenol antioxidants -- substances found in many fruits and vegetables -- may come at a cost to some people. (medicalxpress.com)
  • The antioxidant effect of polyphenols has mainly been studied in vitro, i.e. outside of the human body. (eufic.org)
  • Much of the evidence that supports a protective effect of polyphenols on CVD, cancer and neurodegenerative diseases comes from in vitro studies using human cell cultures and animal studies. (eufic.org)
  • Furthermore, many of the studies investigating the effect of polyphenols on health outcomes use polyphenol-rich foods rather than isolated polyphenols. (eufic.org)
  • 6,7 Another therapeutically relevant effect of polyphenols on the cardiovascular system may be their ability to interact with the pathway leading to the generation of NO from vascular endothelium. (ahajournals.org)
  • 8,9 This pharmacological effect of polyphenols is of importance because NO has vasorelaxant and antiaggregatory properties, and in the longer term, it induces the expression of genes protective of the cardiovascular system. (ahajournals.org)
  • Antihyperglycemic Effect of Polyphenols from Acerola (Malpighia emarginata DC. (nii.ac.jp)
  • The same review also found that flavonoids seem to be the type of polyphenol most often associated with a lower risk for type 2 diabetes. (medicalnewstoday.com)
  • One study compared the intake of flavonoids, a class of polyphenols, with body mass index ( BMI ) and waist circumference. (medicalnewstoday.com)
  • Polyphenols include flavonoids, tannic acid, and ellagitannin, some of which have been used historically as dyes and for tanning garments. (wikipedia.org)
  • Several polyphenols including flavonoids such as baicalein, daidzein, luteolin, and nobiletin as well as nonflavonoid polyphenols such as auraptene, carnosic acid, curcuminoids, and hydroxycinnamic acid derivatives including caffeic acid phentyl ester enhance neuronal survival and promote neurite outgrowth in vitro, a hallmark of neuronal differentiation. (nih.gov)
  • Cocoa, containing high amount of polyphenols and flavonoids has been reported to play an important protective role against the development of CHD. (worldwidehealth.com)
  • No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. (kb.se)
  • Kevin Croft and Cesar Fraga introduce the Food & Function themed collection for the International Conference on Polyphenols and Health (ICPH2019). (rsc.org)
  • The 4th International Conference on Polyphenols and Health. (eufic.org)
  • According to University of California professor Parris M. Kidd, technologies that bond polyphenols to molecules of phophatidylcholine help to make polyphenols more readily absorbable through the lining of your intestine, thus increasing their bioavailability. (livestrong.com)
  • However, individual variations in metabolic pathways, bioavailability, dose, and toxicity are some important factors that can modify the effectiveness of tea polyphenols within the human system. (bioportfolio.com)
  • The poor water solubility and oral bioavailability of many lipophilic polyphenols can be improved through the use of colloidal delivery systems. (bioportfolio.com)
  • The extraction, isolation and identification methods of polyphenols from grape as well as their bioavailability and potential toxicity also are included. (mdpi.com)
  • While some indicate potential health effects of certain specific polyphenols, most studies demonstrate low bioavailability and rapid excretion of polyphenols, indicating their potential roles only in small concentrations in vivo. (wikipedia.org)
  • Bioavailability and bioefficacy of polyphenols in humans. (nii.ac.jp)
  • The clinical success of the applicability of tea polyphenols awaits efficient systemic delivery and bioavailability. (dovepress.com)
  • The beneficial effects correlated with levels of blueberry polyphenol metabolites in the blood plasma. (theepochtimes.com)
  • In other words, as the blueberry polyphenols were broken down by enzymes into various metabolites, endothelium function in the men improved. (theepochtimes.com)
  • Polyphenols are plant secondary metabolites derived from the phenylpropanoid and polyketide biosynthetic pathways that feature more than one phenolic ring in their basic chemical structure. (els.net)
  • Tea polyphenols, the secondary metabolites of the tea leaf , are increasingly being studied for their antimetastatic properties. (bioportfolio.com)
  • Exudate from seeds of the grape plant Vitis vinifera, composed of oils and secondary plant metabolites (BIOFLAVONOIDS and polyphenols) credited with important medicinal properties. (bioportfolio.com)
  • Polyphenols are a huge group of plant metabolites with varying chemical structures. (clinicaltrials.gov)
  • However in the body, polyphenols are quickly and easily converted into polyphenol metabolites. (innovations-report.com)
  • Relevant polyphenol metabolites that are found in humans were also examined. (innovations-report.com)
  • De Boer's research shows that in vivo research with polyphenol metabolites is necessary to study the effects of polyphenols. (innovations-report.com)
  • Since Ceratocystis minor is central to the death of pines infested by southern pine beetles, changes in polyphenols of infected loblolly pine were examined with regard to accumulation of fungal metabolites and changes in concentrations of fungitoxic and fungistatic phloem and xylem constitutents. (usda.gov)
  • Most of the secondary metabolites are consisted of polyphenols. (thefreelibrary.com)
  • Plants produce polyphenols as secondary metabolites to protect themselves and interact with other plants. (thefreelibrary.com)
  • Recent Advances in Polyphenol Research Volume 2 Edited by Santos-Buelga, Escribano-Bailon and Lattanzio Plant phenolics are secondary metabolites that constitute one of the most common and widespread groups of substances in plants. (whsmith.co.uk)
  • Other polyphenols, that is caffeic acid, p-coumaric acid, and ferulic acid, were found in almost all samples, almost all more abundant than fresh kale, representing a precious source of beneficial metabolites. (scirp.org)
  • Polyphenols, which are secondary plant metabolites found in a wide range of foodstuffs and beverages, may be partially responsible for these effects. (wiley.com)
  • A review of studies looked at the impact of cocoa polyphenols on risk factors for heart disease. (medicalnewstoday.com)
  • Combination of Maqui and Cocoa Polyphenols - supplies 350mg of polyphenols. (zonediet.com)
  • Meal replacement that combines Maqui and Cocoa polyphenols - supplies 250mg of polyphenols. (zonediet.com)
  • In particular, cocoa polyphenols induce release of nitric oxide (NO) through activation of endothelial NO synthase which, in turn, accounts for vasodilation and cardioprotective effects. (frontiersin.org)
  • Quite interestingly, following cocoa and dark chocolate ingestion, cocoa polyphenols also modulate intestinal microbiota, thus leading to the growth of bacteria that trigger a tolerogenic anti-inflammatory pathway in the host. (frontiersin.org)
  • With special reference to cocoa, polyphenols are constituents of the beans and their derivatives from the Theobroma cacao tree. (frontiersin.org)
  • Apple polyphenols are chemicals found in apples. (webmd.com)
  • Apple polyphenols are used for obesity , hay fever , high levels of cholesterol or other fats ( lipids ) in the blood ( hyperlipidemia ), and many other conditions, but there is no good scientific evidence to support these uses. (webmd.com)
  • Apple polyphenols also seem to block fat and cholesterol from entering the body and slow the production of fat and cholesterol. (webmd.com)
  • Early research shows that drinking a drink with apple polyphenols reduces runny nose in people with hay fever . (webmd.com)
  • Early research shows that taking apple polyphenols does not seem to improve blood pressure in people with high blood pressure . (webmd.com)
  • Early research shows that drinking a beverage with apple polyphenols can reduce the amount of body fat in adults who are overweight or obese. (webmd.com)
  • Apple polyphenols are POSSIBLY SAFE when taken short-term. (webmd.com)
  • Taking apple polyphenols might cause mild gastrointestinal side effects, such as diarrhea . (webmd.com)
  • Apple polyphenols are POSSIBLY SAFE when used appropriately. (webmd.com)
  • There isn't enough reliable information to know if apple polyphenols are safe to use when pregnant or breast-feeding. (webmd.com)
  • The appropriate dose of apple polyphenols depends on several factors such as the user's age, health, and several other conditions. (webmd.com)
  • At this time there is not enough scientific information to determine an appropriate range of doses for apple polyphenols. (webmd.com)
  • To make this discovery, scientists used a chemically induced model of colitis with Dextran sulfate sodium (DSS), researchers administered an oral placebo to one group of mice, and the other group of mice was given an oral dose of apple polyphenols every day during the course of the disease. (medindia.net)
  • Results showed that mice treated orally with apple polyphenols were protected from colitis. (medindia.net)
  • In mice lacking T cells, apple polyphenols were unable to protect against colitis or suppress proinflammatory cytokine expression, indicating apple polyphenols protect against colitis via the suppression of T cell activation and/or recruitment. (medindia.net)
  • Apple polyphenols are mostly acknowledged for their hypoglycaemic properties, but represent an apple active fraction with many pharmacological functions. (bioportfolio.com)
  • Apple polyphenols could represent a novel nutritional approach in the management and control of blood glucose, especially in type 2 diabetics. (greenmedinfo.com)
  • Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. (nih.gov)
  • Polyphenols are the biggest group of phytochemicals, and many of them have been found in plant-based foods. (ebscohost.com)
  • This review focuses on polyphenols and phytochemicals present in the plant kingdom that have been recently suggested to exert some positive effects on exercise-induced muscle damage and oxidative stress. (intechopen.com)
  • Although the polyphenols in coffee have many potential health benefits, excessive coffee consumption is linked to health risks. (livestrong.com)
  • The most common UV/Vis spectrophotometry assay involves the monitoring of the formation of o-quinones, which are the products of polyphenol oxidase-catalysed reactions, or the consumption of the substrate. (wikipedia.org)
  • 2002). There are many epidemiological studies suggest that consumption of polyphenol-rich foods and beverages is associated with a reduced risk of cardiovascular diseases, stroke and certain types of cancer in which polyphenol is linked to the antioxidant properties (Barros et al. (scribd.com)
  • Some scientists believe that interventions to improve endothelial function (such as the consumption of red wine or other sources of polyphenols) should begin earlier in life to slow down the endothelial dysfunction that occurs with ageing. (eurekalert.org)
  • Other possible effects may result from consumption of foods rich in polyphenols, but are not yet proved scientifically in humans, so are not allowed as health statements by the FDA. (wikipedia.org)
  • The increased consumption of polyphenols has been associated with a reduced risk of cardiovascular disease and potentially cancer and stroke. (vitanetonline.com)
  • There are large differences in consumption of amount and type of polyphenols between North and South with lower risks associated with the Mediterranean diet. (europa.eu)
  • The consumption of whole-wheat flour, which contains polyphenols, is expected to possibly prevent metabolic disorders such as diabetes, obesity, and the metabolic syndrome. (medicalxpress.com)
  • Glucose tolerance tests to investigate the effect of wheat polyphenols on glucose metabolic function in mice showed that the decline in glucose tolerance that occurred over 10 weeks due to a high-fat, high-sucrose diet had been suppressed by the simultaneous consumption of wheat polyphenols (Fig. 2). (medicalxpress.com)
  • The main objective of the BACCHUS project is to develop tools and resources that will facilitate the generation of robust and exploitable scientific evidence that can be used to support claims of a cause and effect relationship between consumption of bioactive peptides and polyphenols, and beneficial physiological effects related to cardiovascular health in humans. (europa.eu)
  • Resveratrol and quercetin are polyphenols abundant in frequently consumed fruits, vegetables, and red wine. (hindawi.com)
  • Effects of red wine and wine polyphenol resveratrol on platelet a. (ingentaconnect.com)
  • This beneficial effect is increasingly attributed to the polyphenol resveratrol, present in red wine. (ingentaconnect.com)
  • Chapters highlight the anti-inflammatory activity of polyphenols on key dendritic cells, how they modulate and suppress inflammation, and how they are inactivated or activated by metabolism in the gut and circulating blood. (elsevier.com)
  • This study is the first to show a role for T cells in polyphenol-mediated protection against an autoimmune disease and could lead to new therapies and treatments for people with disorders related to bowel inflammation, such as ulcerative colitis, Crohn's disease and colitis-associated colorectal cancer. (medindia.net)
  • It is suggested that polyphenols may favorably supplement sunscreens protection, and may be useful for skin diseases associated with solar UV radiation-induced inflammation, oxidative stress and DNA damage. (nih.gov)
  • Zone Polyphenols work to support the body's natural healing response by aiding in the repair of damage caused by diet and exercise-induced inflammation. (zonediet.com)
  • However, the primary investigation into the ability of polyphenols to act as a countermeasure to inflammation and oxidative stress showed no significant benefits. (rssl.com)
  • Developed with olive oil polyphenols, rich in omega-3 and omega-6 fatty acids, and known to calm redness, irritation and inflammation, this lightweight, hypoallergenic, feel-good formula is ideal for even the most sensitive skin types. (neimanmarcus.com)
  • The term 'polyphenol' should be restricted to define structures that display at least two phenolic rings, irrespective of the number of hydroxy groups they each bear. (els.net)
  • Phlorotannins, red‐brown algal polyphenols derived from phenolic oxidative coupling of phloroglucinol. (els.net)
  • Phenolic acid include caffeic acid Lignans are polyphenols derived from phenylalanine found in flax seed and other cereals. (wikipedia.org)
  • The raspberry ellagitannin (M.W. ~2450), on the other hand, with its 14 gallic acid moieties (most in ellagic acid-type components), and more than 40 phenolic hydroxyl groups, meets the criteria of both definitions of a polyphenol. (wikipedia.org)
  • Most polyphenols contain repeating phenolic moieties of pyrocatechol, resorcinol, pyrogallol, and phloroglucinol connected by esters (hydrolyzable tannins) or more stable C-C bonds (nonhydrolyzable condensed tannins). (wikipedia.org)
  • Phenolic acid profiling, antioxidant, and anti-inflammatory activities, and miRNA regulation in the polyphenols of 16 blueberry samples from China. (greenmedinfo.com)
  • After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (p-trend = 0.019) and phenolic acids (p-trend = 0.007) and differentiated TC risk in subjects with BMI ≥ 25 was observed. (kb.se)
  • To determine whether fruit juice rich in polyphenols might increase exercise capacity and memory in healthy sedentary subjects.Both parameters might be improved because of the anti-oxidant. (bioportfolio.com)
  • and vegetables such as broccoli , cabbage , celery , onion and parsley are rich in polyphenols. (wikipedia.org)
  • freshly brewed tea contains a higher amount of polyphenols per serving than do tea drinks that are canned or bottled. (vitanetonline.com)
  • The amount of polyphenols resulted to be higher than that of raw material, fresh kale (0.57 ± 0.03 mg GAE). (scirp.org)
  • Ogay YA, Zagoruyko VA, Bogadelnikov IV et al (2000) Biologicheski aktivnye svojstva polifenolov vinograda i vina (Biologically active properties of polyphenols of the grape and wine). (springer.com)
  • The properties of polyphenols have only been under investigation since the 1990s, but there is increasing evidence that they contribute to many aspects of our overall health. (livestrong.com)
  • Early research shows that taking apple and grape polyphenols can allow athletes to exercise for a little bit longer before getting tired. (webmd.com)
  • The present review discusses the action of grape polyphenols against diseases and the new polyphenol-rich products developed to be used as nutraceuticals. (eurekaselect.com)
  • Grape polyphenols demonstrated effects such as maintenance of endothelial function, increase in antioxidant capacity and protection against LDL oxidation. (eurekaselect.com)
  • Plant-based foods such as vegetables and fruits tend to be high in polyphenols. (medicalnewstoday.com)
  • Chemistry Professor Joe Vinson, Ph.D., explained that popcorn is approximately 4% water, compared to 90% in most fruit and vegetables - meaning that polyphenols are much more diluted in the fruit and veggies. (medicalnewstoday.com)
  • Polyphenols and carotenoids are abundant in fruits, vegetables, herbs and spices, and beverages, such as tea, cocoa and wine providing health-related benefits and antioxidant properties. (rsc.org)
  • Polyphenol oxidase is an enzyme found throughout the plant and animal kingdoms, including most fruits and vegetables. (wikipedia.org)
  • Fruits and vegetables are sources of polyphenols. (eufic.org)
  • This is why fruits, especially berries, and vegetables are good sources of polyphenols. (zonediet.com)
  • Polyphenols are substances of plant origin that occur in numerous fruits and vegetables. (innovations-report.com)
  • Polyphenols are found in fruits and vegetables, as well as cocoa, tea, and chokeberry and have been shown to be a type of chemical that may protect the body against some common health problems as well as certain effects of aging. (vitanetonline.com)
  • Despite the health benefits of polyphenols, only 1 out of 10 adults meets the recommended 5 servings of fruits and vegetables per day. (zonediet.com)
  • Nonetheless, the levels of polyphenols occurring in fruits and vegetables is only between 0.1 and 0.2 percent by weight. (zonediet.com)
  • To give a sense of what 1,000mg of polyphenols per day looks like, it could be approximately 5 ½ cups of broccoli, 1 ½ cups of blueberries, 2 ¼ cups of strawberries or a combination of various fruits and vegetables. (zonediet.com)
  • A good rule of thumb is that consuming 10 servings of vegetables and fruits per day will provide about 1,000mg of polyphenols per day. (zonediet.com)
  • Since most of us fall short on our intake of fruits and vegetables, let alone meet Dr. Sears' recommended 10 servings per day, supplementing with purified polyphenol is a great way to fill in the gaps. (zonediet.com)
  • Where most fruits, vegetables, and juices can be rich in pesticides and heavy metals, no matter which Zone Polyphenol you choose it has the purity and potency you've come to expect from Dr. Sears. (zonediet.com)
  • Purified blend of 18 fruits and vegetables including Maqui Extract - supplies 100mg of polyphenols. (zonediet.com)
  • Purified blend of 17 fruits and vegetables - supplies 90mg of polyphenols. (zonediet.com)
  • In vitro studies have shown that the beneficial effect of fruits, vegetables, or red wine may be in part explained by the presence of polyphenols. (ahajournals.org)
  • Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. (nih.gov)
  • A number of polyphenol supplements are currently popular with consumers. (livestrong.com)
  • Consult your doctor before taking polyphenol supplements. (livestrong.com)
  • Kidd suggests that this process, called phytosome technology, is underutilized, despite proof that it improves the performance of polyphenol supplements. (livestrong.com)
  • As 'The American Journal of Clinical Nutrition' notes, more study is needed to determine the risks of polyphenol supplements, which may include carcinogenic effects, thyroid toxicity, interactions with prescription medications, antinutritional effects and estrogen-like activity. (livestrong.com)
  • Due to their possible health effect, polyphenols are currently sold as nutritional supplements. (innovations-report.com)
  • The research team at the North Carolina Research Campus (NCRC) in Kannapolis report discovery of enhanced polyphenolic absorption via the colon into the blood stream, and increased ketogenesis 14 hours after exercise in athletes that consumed polyphenol supplements. (rssl.com)
  • Overall, the pooled results show that polyphenols are viable supplements to improve performance in athletes. (intechopen.com)
  • We summarize the recent findings concerning the effects of polyphenols on human health, analyze the current limitations at pitfalls, and propose future directions for research. (nih.gov)
  • Polyphenols have proven effective for key health benefits, including bone health, organ health, cardiac and vascular conditions, absorption and metabolism, and cancer and diseases of the immune system. (elsevier.com)
  • Polyphenols have been known to have many beneficial effects for human health, such as preventing or delaying certain types of cancer, enhancing bone metabolism and improving bone mineral density , and decreasing risk of heart disease," said Okhee Han, assistant professor of nutritional sciences. (medicalxpress.com)
  • 1 Polyphenols have been recognised for their antioxidant properties and as they are the most widespread substances with antioxidant potential in our diet, their biological activities are being investigated by many researchers. (eufic.org)
  • Polyphenols protect cells and body chemicals against damage that is caused by free radicals and block the action of enzymes that cancers need for growth, deactivating substances that promote the growth of cancer. (vitanetonline.com)
  • This information suggests that most of the polyphenols in Douglas-fir bark can be used to make water-proof, formaldehyde free, wood adhesive polymers once we understand the molecular structures and reactions of these natural renewable substances. (oregonstate.edu)
  • Polyphenols may also have anticancer effects in certain population subgroups, though the data supporting this is inconclusive. (livestrong.com)
  • The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). (bioportfolio.com)
  • Many studies have shown that tea polyphenols can be extremely beneficial to human health, possessing anti-obesity, antihypertensive, anti-diabetic, antioxidant, anti-inflammatory, and anticancer effects. (vitanetonline.com)
  • In a study of ' Determination of polyphenols in three Capsicum annuum L. (bell pepper) varieties using high-performance liquid chromatography-tandem mass spectrometry: Their contribution to overall antioxidant and anticancer activity. (worldwidehealth.com)
  • posted in PubMed, researchers found that the antioxidant activity and anticancer effect of the polyphenol mixtures of the three fruits were determined. (worldwidehealth.com)
  • Bioactive polyphenol components of cranberry (Vaccinium macrocarpon) are known to have virulence attenuating effects against several cariogenic virulence properties responsible for dental caries pathogenesis. (cranberryinstitute.org)
  • Although low concentrations of free polyphenols had been found in popcorn in previous studies, its total polyphenols content had never been measured. (medicalnewstoday.com)
  • The team also found that popcorn hulls have the highest polyphenols concentrations, as well as being rich in fiber. (medicalnewstoday.com)
  • However, it is unknown whether polyphenols reach human malignant breast tumours in molecular forms and(or) at concentrations likely to act agains. (bioportfolio.com)
  • The aims of the study are to investigate the effect of different sorghum polyphenol concentrations on human iron absorption and to investigate if the negative impact of the polyphenols can be overcome by using NaFeEDTA as iron compound. (clinicaltrials.gov)
  • Forearm blood flow (FBF) dose-response curves (ratio of infused:non-infused with error bars indicating standard error of mean) during saline and increasing concentrations of acetylcholine (Ach) for high-polyphenol and low-polyphenol diet preintervention and postintervention. (bmj.com)
  • Older leaves used to make Oolong and black teas are more oxidized and contain higher concentrations of other polyphenols including theaflavanins and thearubigins. (sigmaaldrich.com)
  • Research has called into question the role of plant polyphenols in cardiovascular health, by finding that their supposed anti-platelet activities are only relevant at high, and physiologically unattainable, concentrations. (anabolicminds.com)
  • All vegetable tannins are polyphenols, but plant polyphenols are not all capable of tanning actions. (els.net)
  • Hence, many larger polyphenols are biosynthesized in-situ from smaller polyphenols to non-hydrolyzable tannins and remain undiscovered in the plant matrix. (wikipedia.org)
  • For instance, in the Indian subcontinent, the pomegranate peel, high in tannins and other polyphenols, or its juice, is employed in the dyeing of non-synthetic fabrics. (wikipedia.org)
  • Polyphenols, especially tannins, were used traditionally for tanning leather and today also as precursors in green chemistry notably to produce plastics or resins by polymerisation with or without the use of formaldehyde or adhesives for particleboards. (wikipedia.org)
  • The most abundant polyphenols are the condensed tannins, found in virtually all families of plants. (wikipedia.org)
  • It is a dry extract of the Carthaginian berry (Punica granatum), which is concentrated in polyphenols, particularly in tannins (punicalagin) and ellagic derivative, and stabilized in a maltitol carrier. (nutritionaloutlook.com)
  • Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects. (hindawi.com)
  • In fact, cocoa and dark chocolate polyphenols exert antioxidant and anti-inflammatory activities switching on some important signaling pathways such as toll-like receptor 4/nuclear factor κB/signal transducer and activator of transcription. (frontiersin.org)
  • Despite their low presence in olive oil of only about five percent, polyphenols have long attracted the attention of scientists due to their strong antioxidant and anti-inflammatory properties and hypoglycemic action. (oliveoiltimes.com)
  • The study published in PLOS One used supplementation with water soluble polyphenols from blueberry and green tea extracts captured onto a polyphenol soy protein complex (PSPC). (rssl.com)
  • Plant extracts known as tea polyphenols (TP) have been used to enhance and preserve food. (thermofisher.com)
  • A new clinical trial published in the journal Nutrients found that a formulation of polyphenol extracts sourced from grape, grapefruit, green tea, guarana, and black carrot, marketed as Fiit-ns by supplier Fytexia, was able to improve body weight and composition in obese participants, along with significantly improving scores in health-related quality of life questionnaires compared to placebo. (nutraceuticalsworld.com)
  • Apple polyphenol extracts might emerge as a promising nutritional ingredient in the management of chronic diseases such as diabetes. (greenmedinfo.com)
  • Li, H.-B. Biological Activities of Polyphenols from Grapes. (mdpi.com)
  • Xia E-Q, Deng G-F, Guo Y-J, Li H-B. Biological Activities of Polyphenols from Grapes. (mdpi.com)
  • Polyphenols are abundant in red grapes and in their derived products, amongst other natural food sources. (eurekaselect.com)
  • Among subjects with lower levels of anxiety, every 25-mg increase in their daily intake of dark chocolate polyphenols reduced the chances of MetS risk by five percent, after adjustment for gender, age, and physical activity levels. (naturalnews.com)
  • A second study was conducted to investigate the dose of blueberry polyphenols needed to see beneficial effects. (theepochtimes.com)
  • It is important to understand that not all polyphenols have identical effects. (livestrong.com)
  • The demonstration of the beneficial effects of polyphenols will be sensitized by high-fructose feeding for the last 6 days of the protocol. (clinicaltrials.gov)
  • In this report, we review the studies on the effects of polyphenols on neuronal survival, growth, proliferation and differentiation, and the signaling pathways involved in these neurotrophic actions. (nih.gov)
  • Finally, the antioxidant activity of polyphenols reflected in the activation of Nrf2 pathway and the consequent upregulation of detoxification enzymes such as heme oxygenase-1 as well as the contribution of these effects to the neurotrophic activity have also been discussed. (nih.gov)
  • In conclusion, a better understanding of the neurotrophic effects of polyphenols and the concomitant modulations of signaling pathways is useful for designing more effective agents for management of neurodegenerative diseases. (nih.gov)
  • Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions. (bioportfolio.com)
  • There is a wealth of published research on the health-promoting effects of green tea and its various components including polyphenols. (routledge.com)
  • Studying and isolating the effects of polyphenols is not as easy task, and more research is needed. (eufic.org)
  • 2012). Molecular mechanisms of the cardiovascular protective effects of polyphenols. (eufic.org)
  • The laboratory studies conducted in animal models suggest that these polyphenols have the ability to protect the skin from the adverse effects of UV radiation, including the risk of skin cancers. (nih.gov)
  • Much research into the health effects of polyphenols is carried out in vitro. (innovations-report.com)
  • This research was carried out with rats to study the mechanisms and effects of a polyphenol-rich diet. (innovations-report.com)
  • A change in the energy regulation might be an important process for the realisation of possible health effects of polyphenols in the food. (innovations-report.com)
  • This will allow the health effects of polyphenols to be accurately described. (innovations-report.com)
  • A mixed picture arises from a study of the effects of polyphenol supplementation during intensive exercise. (rssl.com)
  • Interested in the effects of tea polyphenols preservation in stored yellow croaker samples, Zhao et al. (thermofisher.com)
  • Zhao, Jin (2013) " Effects of tea polyphenols on the post-mortem integrity of large yellow croaker (Pseudosciaena crocea) fillet proteins . (thermofisher.com)
  • However, few studies have reported the cardiovascular effects of RWPCs, inasmuch as it is not known whether a sufficient level of polyphenols can be reached in the circulation after oral administration of RWPCs. (ahajournals.org)
  • A new study categorized the extra virgin olive oils of Greece according to their load of polyphenols and further explored the effects of oleocanthal and oleacein on live organisms. (oliveoiltimes.com)
  • After mapping the extra virgin olive oils of Greece according to their pack of polyphenols, the study was stretched to test the effects of oleocanthal and oleacein in live cells, first by injecting them into human skin fibroblasts and then to a number of flies of the Drosophila strain. (oliveoiltimes.com)
  • Effects of green tea polyphenol on cognitive and acetylcholinesterase activities. (life-enhancement.com)
  • Researchers from the National Institute of Advanced Industrial Science and Technology (AIST), have discovered that wheat polyphenols have effects that improve the rhythm of activity and suppress obesity and glucose intolerance in model mice of diet-induced obesity, in collaboration with Nisshin Seifun Group Inc. (medicalxpress.com)
  • Polyphenols have a large and diverse array of beneficial effects on both plants and animals. (whsmith.co.uk)
  • After ingestion, polyphenols are metabolised and therefore may not be present in the body in the forms they were tested in in vitro studies. (eufic.org)
  • [1] Ingestion of polyphenols occurs by consuming a wide array of plant foods. (wikipedia.org)
  • Further, these two polyphenols inhibit growth of pancreatic cancer cell line, Panc02, in vitro. (hindawi.com)
  • The use of chemopreventive agents, such as plant polyphenols, to inhibit these events in UV-exposed skin is gaining attention. (nih.gov)
  • On average, people consume about 10 times more polyphenols than they do vitamin C. Coffee contains a type of polyphenol called chlorogenic acids, which are esters of quinic and cinnamic acids. (livestrong.com)
  • Some researchers have reported that polyphenols may lower the risk for type 2 diabetes . (medicalnewstoday.com)
  • Researchers have recently identified the positive interactions between polyphenols and intestinal bacteria, leading to classification as a prebiotic function. (nutraingredients.com)
  • The researchers measured changes in FMD at 0, 1, 2, 4 and 6 hours after the men drank the blueberry polyphenols. (theepochtimes.com)
  • Polyphenols are an expanding area of nutritional discovery, but much work needs to be done before researchers fully understand the implications of polyphenol supplement use. (livestrong.com)
  • The researchers found that polyphenols were much more abundant in popcorn than they had expected. (medicalnewstoday.com)
  • The researchers from the University of Athens and the University of Innsbruck, Austria, examined 134 extra virgin olive oils in total, focusing on their antioxidant component, the polyphenols (also called biophenols), and specifically oleocanthal and oleacein. (oliveoiltimes.com)
  • The study revealed, for the first time, that "a mixture of natural citrus polyphenols from bergamot is able to stimulate lipophagy in the liver under hypercaloric stress," according to researchers. (nutritionaloutlook.com)
  • In this study, the researchers used model mice of diet-induced obesity that exhibited a nocturnal shift in activity as well as glucose intolerance and obesity in order to evaluate the functionality of wheat polyphenols. (medicalxpress.com)
  • The aim of this is study is to evaluate the acute effect of grape and pomegranate polyphenols in the modulation of markers of metabolic syndrome. (bioportfolio.com)
  • Read on to learn more about what foods are high in polyphenols, as well as the possible health benefits of consuming them. (medicalnewstoday.com)
  • The health benefits of pomegranate have long been associated with the high content of antioxidant polyphenols and Pomella delivers those benefits in a. (nutraingredients-usa.com)
  • Polyphenols are a hot topic among functional food proponents due to increasing evidence that they can impact your health in positive ways. (livestrong.com)
  • Eating a diet rich in plant material confers a number of health benefits, including the benefits of polyphenols. (wisegeek.com)
  • Polyphenols: Mechanisms of Action in Human Health and Disease, Second Edition describes the mechanisms of polyphenol antioxidant activities and their use in disease prevention. (elsevier.com)
  • Black soybean ( Glycine max L.), a cultivar containing abundant polyphenols in its seed coat such as anthocyanins and flavan-3-ols, has been reported to possess various health benefits toward lifestyle diseases. (rsc.org)
  • Some polyphenols can prevent stress responses, which subsequently prevent stress-related health problems. (rsc.org)
  • To date the European Food Safety Authority, which is scientifically assessing health claims made on food products, has rejected all claims on polyphenols except for olive oil. (eufic.org)
  • International Scientific Forum on Alcohol Research members thought that this was an excellent paper, as it begins to delve into mechanisms by which polyphenols improve health. (eurekalert.org)
  • Polyphenols are nutrients found in plants that are responsible for their health-promoting properties. (zonediet.com)
  • Polyphenols: A concise overview on the chemistry, occurrence, and human health. (semanticscholar.org)
  • Polyphenol-rich diets have been linked to many health benefits. (ebscohost.com)
  • This paper is intended to review the chemistry and biochemistry of polyphenols as related to classification, extraction, separation and analytical methods, their occurrence and biosynthesis in plants, and the biological activities and implications in human health. (ebscohost.com)
  • Yet the scientific basis for the health claims for polyphenols is mostly weak. (innovations-report.com)
  • The Importance of Polyphenols as Functional Food in Health. (thefreelibrary.com)
  • ICPH is the most important international forum to present and discuss the latest trends, topics and developments in the field of polyphenols, food science and health. (rsc.org)
  • It was deduced that integrated cultivation yields olive oils with the highest level of polyphenols, followed by the organic and then conventional cultivation. (oliveoiltimes.com)
  • Some sorghum varieties are known to contain high levels of polyphenols which have an inhibitory effect on iron absorption in humans. (clinicaltrials.gov)
  • No information about the potential enhancing effect of NaFeEDTA in presence of polyphenol is available. (clinicaltrials.gov)
  • Enzyme assays in the presence of polyphenol oxidase inhibitors support the results of the activity staining. (usda.gov)
  • This provides new starting points for further research into the molecular mechanisms of polyphenols. (innovations-report.com)
  • Epidemiological data suggests that a diet high in polyphenol-rich foods, such as berries and dark chocolate, is associated with lower cardiovascular disease risk. (bmj.com)
  • The polyphenols found in tea also appear to suppress the growth of harmful bacteria, while promoting beneficial bacteria in the gut. (wisegeek.com)
  • The present study in rats found that the administration of red wine polyphenols protected against ageing-induced endothelial dysfunction. (eurekalert.org)
  • Modern science has found that edible plants are to be valued for their high vitamin and fiber along with their rich store of polyphenols. (vitanetonline.com)
  • The polyphenols found in cocoa occur in a higher concentration than can be found in any other food. (vitanetonline.com)
  • Polyphenols make up most of the components found in all vegetative organs, fruits and flowers. (thefreelibrary.com)
  • In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. (diigo.com)
  • Extra virgin olive oils from Crete were found to contain the highest polyphenols load. (oliveoiltimes.com)
  • It was found that extra virgins from Crete , and especially from the areas of Lasithi and Heraklion, were the richest in polyphenols. (oliveoiltimes.com)
  • A was found to produce cellulases and polyphenol oxidase. (usda.gov)
  • Penn State nutritional scientists found that eating certain polyphenols decreased the amount of iron the body absorbs, which can increase the risk of developing an iron deficiency. (medicalxpress.com)
  • They used cells from the intestine - where iron absorption takes place - to assess the polyphenols' effect and found that polyphenols bind to iron in the intestinal cells, forming a non-transportable complex. (medicalxpress.com)
  • In multivariable-adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HRQ4 vs. Q1 = 0.99, 95% confidence interval [CI] 0.77-1.29), papillary (HRQ4 vs. Q1 = 1.06, 95% CI 0.80-1.41) or follicular TC (HRQ4 vs. Q1 = 1.10, 95% CI 0.55-2.22) were found. (kb.se)
  • BACKGROUND&OBJECTIVE: Plant polyphenols have been known to exert anti-diabetic action and promote insulin action. (greenmedinfo.com)
  • Unlike vitamins and minerals, polyphenols are not essential nutrients meaning that they are not required by the human body for sustaining life but they can exert beneficial functions. (eufic.org)
  • It is thought that polyphenols may exert a cardio protective effect via several pathways. (eufic.org)
  • A polyphenol antioxidant is a type of antioxidant containing a polyphenolic substructure and studied in vitro . (wikipedia.org)
  • All Zone Polyphenols have the purity and potency you've come to expect from Dr. Sears. (zonediet.com)
  • Several assays were developed to monitor the activity of polyphenol oxidases and to evaluate the inhibition potency of polyphenol oxidase inhibitors. (wikipedia.org)
  • The objectives of this research were to isolate and determine the molecular structures of certain polyphenols in Douglas-fir and red alder barks. (oregonstate.edu)
  • Lignans are a class of polyphenols that occur at their highest levels in virgin olive oil, flaxseed, and whole grain rye flour. (medicalnewstoday.com)
  • Typical compositions contain from about 0.25% to about 10% of a polyphenol preparation obtained from olive oil. (freepatentsonline.com)
  • 1. A method for the treatment of a skin condition selected from the group consisting of eczema, dermatitis, seborrhea, xerosis, rosacea, thermal or radiation burns, and psoriasis, comprising topically applying to affected skin areas a composition containing an effective amount of olive oil polyphenols selected from the group consisting of hydroxytyrosol, oleoeuropeine, and mixtures thereof. (freepatentsonline.com)
  • 2. A method according to claim 1 wherein the olive oil polyphenols are derived from olive oil. (freepatentsonline.com)
  • 4. A method according to claim 1 wherein the composition comprises olive oil enriched with polyphenols. (freepatentsonline.com)
  • 17. A method for the treatment of contact dermatitis comprising topically applying to affected skin areas a composition containing from about 0.1% to about 10% by weight olive oil polyphenols selected from the group consisting of hydroxytyrosol, oleoeuropeine, and mixtures thereof. (freepatentsonline.com)
  • The study was also the first to shed light on the effect of cultivation practices on the polyphenols in olive oil. (oliveoiltimes.com)