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PolyphenolsPhenolsFlavonoidsTeaCatechinWineBiflavonoidsCamellia sinensisPlant ExtractsPolymersProanthocyanidinsGallic AcidAntioxidantsQuercetinVitisHydrolyzable TanninsTanninsChlorogenic AcidAnticarcinogenic AgentsStilbenesAnthocyaninsCacaoMalusGrape Seed ExtractBiological AvailabilityPhytotherapyBeveragesFruitEllagic AcidRutinPhotiniaPyrogallolFood AnalysisPunicaceaeCurcuminVaccinium macrocarponFlavonolsCaffeic AcidsDietHibiscusBlueberry PlantCrataegusAustriaArthropodsSoilDiet, MediterraneanNutsPlanariansCopyrightWritingLycopersicon esculentumParental ConsentAuthorship
Polyphenols: A large class of organic compounds having more than one PHENOL group.Phenols: Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.Flavonoids: A group of phenyl benzopyrans named for having structures like FLAVONES.Tea: The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.Wine: Fermented juice of fresh grapes or of other fruit or plant products used as a beverage.Biflavonoids: Dimers (homo and hetero) of FLAVONOIDS.Camellia sinensis: Camellia sinensis L. (formerly Thea sinensis) is an evergreen Asiatic shrub of the THEACEAE family. The infusion of leaves of this plant is used as Oriental TEA which contains CAFFEINE; THEOPHYLLINE; and epigallocatechin gallate.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Proanthocyanidins: Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They are structurally similar to ANTHOCYANINS but are the result of a different fork in biosynthetic pathways.Gallic Acid: A colorless or slightly yellow crystalline compound obtained from nutgalls. It is used in photography, pharmaceuticals, and as an analytical reagent.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Quercetin: A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.Vitis: A plant genus in the family VITACEAE, order Rhamnales, subclass Rosidae. It is a woody vine cultivated worldwide. It is best known for grapes, the edible fruit and used to make WINE and raisins.Hydrolyzable Tannins: Polymeric derivatives of GALLIC ACID that are esters of a sugar.Tannins: Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.Chlorogenic Acid: A naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. (From J Chromatogr A 1996;741(2):223-31; Biosci Biotechnol Biochem 1996;60(5):765-68).Anticarcinogenic Agents: Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.Anthocyanins: A group of FLAVONOIDS derived from FLAVONOLS, which lack the ketone oxygen at the 4-position. They are glycosylated versions of cyanidin, pelargonidin or delphinidin. The conjugated bonds result in blue, red, and purple colors in flowers of plants.Cacao: A tree of the family Sterculiaceae (or Byttneriaceae), usually Theobroma cacao, or its seeds, which after fermentation and roasting, yield cocoa and chocolate.Malus: A plant genus in the family ROSACEAE, order Rosales, subclass Rosidae. It is best known as a source of the edible fruit (apple) and is cultivated in temperate climates worldwide.Grape Seed Extract: Exudate from seeds of the grape plant Vitis vinifera, composed of oils and secondary plant metabolites (BIOFLAVONOIDS and polyphenols) credited with important medicinal properties.Biological Availability: The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Beverages: Liquids that are suitable for drinking. (From Merriam Webster Collegiate Dictionary, 10th ed)Fruit: The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.Ellagic Acid: A fused four ring compound occurring free or combined in galls. Isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used in research and as a dye.Rutin: A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.Photinia: A plant genus of the family ROSACEAE. The common names of chokeberry or chokecherry are also used for some species of PRUNUS.Pyrogallol: A trihydroxybenzene or dihydroxy phenol that can be prepared by heating GALLIC ACID.Food Analysis: Measurement and evaluation of the components of substances to be taken as FOOD.Punicaceae: A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida that is a small family with a single genus.Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.Vaccinium macrocarpon: A plant species of the family VACCINIUM known for the sour fruit which is sometimes used for urinary tract infections.Flavonols: A group of 3-hydroxy-4-keto-FLAVONOIDS.Caffeic Acids: A class of phenolic acids related to chlorogenic acid, p-coumaric acid, vanillic acid, etc., which are found in plant tissues. It is involved in plant growth regulation.Diet: Regular course of eating and drinking adopted by a person or animal.Hibiscus: A plant genus of the family MALVACEAE. Members contain CITRIC ACID; MALATES; ANTHOCYANINS; FLAVONOIDS; GLYCOSIDES; DIETARY FIBER; and LIGNANS. Hibiscus sabdariffa is common constituent of HERBAL TEAS. Hibiscus cannabinus is a source of hemp fiber for TEXTILES.Blueberry Plant: Several plant species of the genus VACCINIUM known for the edible blueberry fruit.Crataegus: A genus in the family ROSACEAE of shrubs and small trees native to the North Temperate Zone. It is best known for a traditional medication for the heart.AustriaArthropods: Members of the phylum Arthropoda, composed of organisms having a hard, jointed exoskeleton and paired jointed legs. It includes the class INSECTS and the subclass ARACHNIDA, many species of which are important medically as parasites or as vectors of organisms capable of causing disease in man.Soil: The unconsolidated mineral or organic matter on the surface of the earth that serves as a natural medium for the growth of land plants.Diet, Mediterranean: A diet typical of the Mediterranean region characterized by a pattern high in fruits and vegetables, EDIBLE GRAIN and bread, potatoes, poultry, beans, nuts, olive oil and fish while low in red meat and dairy and moderate in alcohol consumption.Nuts: Botanically, a type of single-seeded fruit in which the pericarp enclosing the seed is a hard woody shell. In common usage the term is used loosely for any hard, oil-rich kernel. Of those commonly eaten, only hazel, filbert, and chestnut are strictly nuts. Walnuts, pecans, almonds, and coconuts are really drupes. Brazil nuts, pistachios, macadamias, and cashews are really seeds with a hard shell derived from the testa rather than the pericarp.Planarians: Nonparasitic free-living flatworms of the class Turbellaria. The most common genera are Dugesia, formerly Planaria, which lives in water, and Bipalium, which lives on land. Geoplana occurs in South America and California.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Writing: The act or practice of literary composition, the occupation of writer, or producing or engaging in literary work as a profession.Lycopersicon esculentum: A plant species of the family SOLANACEAE, native of South America, widely cultivated for their edible, fleshy, usually red fruit.Parental Consent: Informed consent given by a parent on behalf of a minor or otherwise incompetent child.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.

Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. (1/1083)

Identification of common dietary substances capable of affording protection or modulating the onset and severity of arthritis may have important human health implications. An antioxidant-rich polyphenolic fraction isolated from green tea (green tea polyphenols, GTPs) has been shown to possess anti-inflammatory and anticarcinogenic properties in experimental animals. In this study we determined the effect of oral consumption of GTP on collagen-induced arthritis in mice. In three independent experiments mice given GTP in water exhibited significantly reduced incidence of arthritis (33% to 50%) as compared with mice not given GTP in water (84% to 100%). The arthritis index also was significantly lower in GTP-fed animals. Western blot analysis showed a marked reduction in the expression of inflammatory mediators such as cyclooxygenase 2, IFN-gamma, and tumor necrosis factor alpha in arthritic joints of GTP-fed mice. Histologic and immunohistochemical analysis of the arthritic joints in GTP-fed mice demonstrated only marginal joint infiltration by IFN-gamma and tumor necrosis factor alpha-producing cells as opposed to massive cellular infiltration and fully developed pannus in arthritic joints of non-GTP-fed mice. The neutral endopeptidase activity was approximately 7-fold higher in arthritic joints of non-GTP-fed mice in comparison to nonarthritic joints of unimmunized mice whereas it was only 2-fold higher in the arthritic joints of GTP-fed mice. Additionally, total IgG and type II collagen-specific IgG levels were lower in serum and arthritic joints of GTP-fed mice. Taken together our studies suggest that a polyphenolic fraction from green tea that is rich in antioxidants may be useful in the prevention of onset and severity of arthritis.  (+info)

Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3'-digallate. (2/1083)

Previous studies in our laboratory have shown that the major green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), suppressed autophosphorylation of epidermal growth factor (EGF) receptor induced by EGF in human A431 epidermoid carcinoma cells. In this study, we examined the inhibitory effects of black tea polyphenols, including theaflavin (TF-1), a mixture (TF-2) of theaflavin-3-gallate (TF-2a) and theaflavin-3'-gallate (TF-2b), theaflavin-3,3'-digallate (TF-3) and the thearubigin fraction on the autophosphorylation of the EGF and PDGF receptors in A431 cells and mouse NIH3T3 fibroblast cells, respectively. First, we examined the effects of these polyphenols on the proliferation of A431 and NIH3T3 cells. Both EGCG and TF-3 strongly inhibited the proliferation of A431 and NIH3T3 cells more than the other theaflavins did. In cultured cells with pre-treatment of tea polyphenol, TF-3 was stronger than EGCG on the reduction of EGF receptor and PDGF receptor autophosphorylation induced by EGF and PDGF, respectively. Other theaflavins slightly reduced the autophosphorylation of the EGF and PDGF receptors; furthermore, TF-3 could reduce autophosphorylation of the EGF receptor (or PDGF receptor) even with co-treatment with EGF (or PDGF) and TF-3, but EGCG was inactive under these conditions. In addition, TF-3 was stronger than EGCG in blocking EGF binding to its receptor. These results suggest that not only the green tea polyphenol, EGCG, but also the black tea polyphenol, TF-3, have an antiproliferative activity on tumor cells, and the molecular mechanisms of antiproliferation may block the growth factor binding to its receptor and thus suppress mitogenic signal transduction.  (+info)

Prostate cancer chemoprevention by green tea: in vitro and in vivo inhibition of testosterone-mediated induction of ornithine decarboxylase. (3/1083)

Recently, we have shown that ornithine decarboxylase (ODC), a rate-controlling enzyme in the polyamine biosynthetic pathway, is overexpressed in prostate cancer (PCA) and prostatic fluid in humans (R. R. Mohan et al., Clin. Cancer Res., 5: 143-147, 1999). ODC is also characterized as an androgen-responsive gene, and the androgenic stimulation regulates the development and growth of both normal and tumorigenic prostate cells. Thus, chemopreventive approaches aimed toward the modulation of ODC could be effective against PCA. Green tea polyphenols (GTPs) possess strong chemopreventive properties against a variety of animal tumor models and in some human epidemiological studies. At least two epidemiological studies have suggested that people who consume tea regularly may have a decreased risk of PCA. In this study, we investigated the effect of GTPs against testosterone-mediated induction of ODC in human prostate carcinoma cells, LNCaP as an in vitro model, and in Cpb:WU rats and C57BL/6 mice as in vivo models. Treatment of LNCaP cells with testosterone resulted in induction of ODC activity in a dose-dependent manner. Pretreatment of the cells with GTPs resulted in a significant inhibition of testosterone-caused induction of ODC activity in a dose-dependent manner. Similar effects of GTPs were observed in anchorage-independent growth assay of LNCaP cells where pretreatment of the cells with GTP was found to result in dose-dependent inhibition of colony formation. Testosterone treatment of the cells resulted in a significant increase in the level of ODC mRNA, and this increase was almost completely abolished by prior treatment of the cells with GTPs. The administration of testosterone (10 mg/kg body weight, i.p.) to sham-operated and castrated Cpb:WU rats resulted in 2- and 38-fold increases in ODC activity, respectively, in the ventral prostate. Oral feeding of 0.2% GTPs in drinking water for 7 days before testosterone administration resulted in 20 and 54% decreases in testosterone-caused induction of ODC activity in sham-operated and castrated rats, respectively. Similar results were obtained with C57BL/6 mice, where testosterone treatment at similar dosage resulted in a 2-fold increase in ODC activity in the ventral prostate and prior oral feeding with 0.2% GTPs resulted in 40% inhibition in this induction.  (+info)

Histological analysis and ancient DNA amplification of human bone remains found in caius iulius polybius house in pompeii. (4/1083)

Thirteen skeletons found in the Caius Iulius Polybius house, which has been the object of intensive study since its discovery in Pompeii 250 years ago, have provided an opportunity to study either bone diagenesis by histological investigation or ancient DNA by polymerase chain reaction analysis. DNA analysis was done by amplifying both X- and Y-chromosomes amelogenin loci and Y-specific alphoid repeat locus. The von Willebrand factor (vWF) microsatellite locus on chromosome 12 was also analyzed for personal identification in two individuals showing alleles with 10/11 and 12/12 TCTA repeats, respectively. Technical problems were the scarcity of DNA content from osteocytes, DNA molecule fragmentation, microbial contamination which change bone structure, contaminating human DNA which results from mishandling, and frequent presence of Taq DNA polymerase inhibiting molecules like polyphenols and heavy metals. The results suggest that the remains contain endogenous human DNA that can be amplified and analyzed. The amplifiability of DNA corresponds to the bone preservation and dynamics of the burial conditions subsequent to the 79 A.D. eruption.  (+info)

Quinol-glutathione conjugate-induced mutation spectra in the supF gene replicated in human AD293 cells and bacterial MBL50 cells. (5/1083)

Hydroquinone is a nephrocarcinogen in rats but generally tests negative in standard mutagenicity assays. However, 2,3,5-tris-(glutathion-S-yl)hydroquinone, a potent nephrotoxic metabolite of hydroquinone, and 2-bromo-bis-(glutathion-S-yl)hydroquinone, another cytotoxic quinol-glutathione (GSH) conjugate, cause extensive single strand breaks in DNA in a manner that is dependent on the formation of reactive oxygen species. We, therefore, investigated whether quinol-GSH conjugates have the potential to behave as genotoxicants. The shuttle vector pSP189, containing the supF gene, was treated with 2,3,5-tris-(glutathion-S-yl)hydroquinone and replicated in both human AD293 cells and Escherichia coli MBL50 cells. The mutation frequency increased 4.6- and 2.6-fold in human AD293 and bacterial MBL50 cells, respectively. Base substitutions were the major type of mutations, and they occurred predominantly at G:C sites in both cell types. A high frequency of deletions (30%), including < 10- and > 10-bp deletions, were observed in AD293-replicated plasmids. The most common types of mutations in AD293 cells were G:C to A:T transitions (33.8%) and G:C to T:A (29.4%) and G:C to C:G (19.1%) transversions. In MBL50 cells, the major mutations were G:C to T:A (33.8%) and G:C to C:G (31.3%) transversions and G:C to A:T transitions (27.5%). The mutation spectra were similar to those reported for *OH-induced mutations, suggesting that *OH generated from polyphenolic-GSH conjugates not only plays a role in cytotoxicity but also provides a basis for their mutagenicity and carcinogenicity.  (+info)

Dietary supplementation of grape polyphenols to rats ameliorates chronic ethanol-induced changes in hepatic morphology without altering changes in hepatic lipids. (6/1083)

Increase in oxidative stress after chronic ethanol consumption can result in hepatic injury. Because polyphenolic compounds can offer antioxidant protection to the cardiovascular system, this study was designed to investigate whether dietary supplementation of polyphenols from grapes may ameliorate hepatic injury resulting from chronic ethanol consumption. Male Sprague-Dawley rats were administered the following diets for 2 mo: 1) Lieber-DeCarli (L-D) diet with isocaloric amount of maltose instead of ethanol (Basal), 2) the L-D diet with 50g/L ethanol (EtOH); 3) L-D diet with 50 mg/L of grape polyphenols (GP) and 4) ethanol diet with GP (EtOH + GP). Rats given EtOH or EtOH + GP diets had significantly more hepatic triacylglycerols (P < 0.0001) and lipid peroxidation products (P < 0.01) compared with those given the Basal and GP diets. In addition, ethanol ingestion also decreased significantly (P < 0.01) the proportion of 16:0 and increased 18:0 and 18:1 in hepatic phospholipids, suggesting a perturbation of the de novo fatty acid biosynthesis pathways. However, GP supplementation alone and GP added to the ethanol diet did not alter the lipid changes mediated by ethanol except for the levels of 22:6(n-3) which were significantly (P < 0.05) higher in the EtOH + GP group than in the EtOH group. Despite a lack of gross lipid changes, histologic assessment showed significantly (P < 0.05) less hepatic damage in the GP + EtOH group compared with the EtOH group. These results clearly distinguished ethanol-mediated changes in hepatic morphology from the changes in hepatic lipids and further demonstrated the ability of GP to ameliorate hepatic damage resulting from chronic ethanol consumption.  (+info)

Polyphenol tannic acid inhibits hydroxyl radical formation from Fenton reaction by complexing ferrous ions. (7/1083)

Tannic acid (TA), a plant polyphenol, has been described as having antimutagenic, anticarcinogenic and antioxidant activities. Since it is a potent chelator of iron ions, we decided to examine if the antioxidant activity of TA is related to its ability to chelate iron ions. The degradation of 2-deoxyribose induced by 6 microM Fe(II) plus 100 microM H2O2 was inhibited by TA, with an I50 value of 13 microM. Tannic acid was over three orders of magnitude more efficient in protecting against 2-deoxyribose degradation than classical *OH scavengers. The antioxidant potency of TA was inversely proportional to Fe(II) concentration, demonstrating a competition between H2O2 and AT for reaction with Fe(II). On the other hand, the efficiency of TA was nearly unchanged with increasing concentrations of the *OH detector molecule, 2-deoxyribose. These results indicate that the antioxidant activity of TA is mainly due to iron chelation rather than *OH scavenging. TA also inhibited 2-deoxyribose degradation mediated by Fe(III)-EDTA (iron = 50 microM) plus ascorbate. The protective action of TA was significantly higher with 50 microM EDTA than with 500 microM EDTA, suggesting that TA removes Fe(III) from EDTA and forms a complex with iron that cannot induce *OH formation. We also provided evidence that TA forms a stable complex with Fe(II), since excess ferrozine (14 mM) recovered 95-96% of the Fe(II) from 10 microM TA even after a 30-min exposure to 100-500 microM H2O2. Addition of Fe(III) to samples containing TA caused the formation of Fe(II)n-TA, complexes, as determined by ferrozine assays, indicating that TA is also capable of reducing Fe(III) ions. We propose that when Fe(II) is complexed to TA, it is unable to participate in Fenton reactions and mediate *OH formation. The antimutagenic and anticarcinogenic activity of TA, described elsewhere, may be explained (at least in part) by its capacity to prevent Fenton reactions.  (+info)

Red wine inhibits monocyte chemotactic protein-1 expression and modestly reduces neointimal hyperplasia after balloon injury in cholesterol-Fed rabbits. (8/1083)

BACKGROUND: Wine consumption decreases the risk of myocardial infarction. Intimal hyperplasia contributes to restenosis after angioplasty. Local ethanol delivery inhibits intimal hyperplasia after balloon injury in rabbit iliac and pig coronary arteries. The effects of wine consumption on intimal response and monocyte chemotactic protein-1 (MCP-1) expression were studied in cholesterol-fed rabbits. METHODS AND RESULTS: Male rabbits were fed a 2% cholesterol diet together with red wine (12.5% vol, 5 mL/kg body wt per day; n=7), white wine (13.3% vol, 5 mL/kg body wt per day; n=7), or no wine as a control (n=8) for 6 weeks. A balloon injury of the abdominal aorta was performed at the end of the third week. Abdominal aortas were harvested at the end of 6 weeks. Neointimal hyperplasia was measured morphometrically. MCP-1 expression was determined by Northern blot, in situ hybridization, and immunohistochemistry. Rabbits fed red wine had significantly less neointimal hyperplasia than did control rabbits (intima/media area ratio 0.59+/-0.05 [red wine group] versus 0.79+/-0.07 [control group], P<0.05). However, rabbits fed white wine showed a trend (but not significant) toward less intimal response compared with control rabbits (intima/media area ratio 0.65+/-0.04 [white wine group] versus 0.79+/-0.07 [control group], P=0.165). Both red wine and white wine significantly reduced MCP-1 mRNA and protein expression in the aorta. CONCLUSIONS: Long-term consumption of red wine and white wine inhibits MCP-1 expression, and in the small number of animals studied, red wine modestly reduces neointimal hyperplasia. Since red wine exhibits higher antioxidant capacity than does white wine, the decreased intimal response might be partly attributed to its antioxidant effects.  (+info)

Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase<...Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase<...
TY - JOUR. T1 - Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase. AU - Li, Changhong. AU - Allen, Aron. AU - Kwagh, Jae. AU - Doliba, Nicolai M.. AU - Qin, Wei. AU - Najafi, Habiba. AU - Collins, Heather W.. AU - Matschinsky, Franz M.. AU - Stanley, Charles A.. AU - Smith, Thomas J.. PY - 2006/4/14. Y1 - 2006/4/14. N2 - Insulin secretion by pancreatic β-cells is stimulated by glucose, amino acids, and other metabolic fuels. Glutamate dehydrogenase (GDH) has been shown to play a regulatory role in this process. The importance of GDH was underscored by features of hyperinsulinemia/hyperammonemia syndrome, where a dominant mutation causes the loss of inhibition by GTP and ATP. Here we report the effects of green tea polyphenols on GDH and insulin secretion. Of the four compounds tested, epigallocatechin gallate (EGCG) and epicatechin gallate were found to inhibit GDH with nanomolar ED50 values and were therefore found to be as potent as the physiologically ...
Selection of Solvent for Recovery of Polyphenols from Pink Guava Processing Wastes by Membrane TechnologySelection of Solvent for Recovery of Polyphenols from Pink Guava Processing Wastes by Membrane Technology
Pink Guava waste obtained after juice processing still contains large amounts of polyphenols, which act as antioxidants. Our previous study has indicated that pink guava waste obtained after juice processing still contain large amounts of polyphenols, which act as antioxidants. The effect of different solvents, mix concentration between MethanollWater, extraction time and ratio waste/solvent on the yield of e"tracted antioxidants from three sources of pink guava processing wastes to optimize the extraction was investigated . Folin-Ciocalteau method was used to determine the total polyphenols content. Total polyphenols content from 0.03 to 0.12 mg/g and the highest is by using methanol as a solvent. The highest polyphenols content at mix concentration between 60% methanOl/water, concentration of polyphenols increased by increasing extraction time and the highest polyphenols extraction observed when using I g waste/25 ml methanol/water 60% as solvent. Membrane technologies are presented as ...
Impact of dietary polyphenols on human platelet function - A critical review of controlled dietary intervention studies -...Impact of dietary polyphenols on human platelet function - A critical review of controlled dietary intervention studies -...
Cardiovascular disease is a chronic disease influenced by many factors, with activated blood platelets being one of them. Platelets play a central role in the formation of plaques within blood vessels, contributing to early inflammatory events. Consumption of diets rich in plant-based products protects against the development of cardiovascular disease. Polyphenols, which are secondary plant metabolites found in a wide range of foodstuffs and beverages, may be partially responsible for these effects. Their protective properties include inhibitory effects on platelet function in vitro and in vivo. However, the bioavailability of many polyphenols is poor and it is unclear whether sufficient quantities can be obtained by dietary means to exert protective effects. Consequently, this review summarizes 25 well-controlled human intervention studies examining the effect of polyphenol-rich diets on platelet function. These studies report a huge variety of research methods, study designs, and study ...
Polyphenols: Biological Activities, Molecular Targets, and the Effect of Methylation | Bentham SciencePolyphenols: Biological Activities, Molecular Targets, and the Effect of Methylation | Bentham Science
Title: Polyphenols: Biological Activities, Molecular Targets, and the Effect of Methylation. VOLUME: 1 ISSUE: 3. Author(s):K. R. Landis-Piwowar and Q. P. Dou. Affiliation:Karmanos Cancer Institute, 540.01 HWCRC 4100 John R Road, Detroit, Michigan 48201-2013, USA.. Keywords:Proteasome inhibitor, molecular target, natural product, drug discovery, anticancer. Abstract: Polyphenolic compounds are widely distributed in the plant kingdom and the anticancer benefits obtained from their consumption have been studied extensively. However, polyphenols are subject to various biotransformation reactions within the human body including methylation. Likewise, naturally occurring polyphenols may contain O-methylations in place of the hydroxyls of the parent compounds. While some studies suggest that methylations can increase the bioavailability of polyphenols, other studies indicate a decrease in the anticancer benefits of methylated polyphenols. This review will focus on the cellular activities of ...
Abstract 73: Tea Polyphenols Improve the Outcome of CPR in an Asphyxial Rat Model | CirculationAbstract 73: Tea Polyphenols Improve the Outcome of CPR in an Asphyxial Rat Model | Circulation
Introduction: Cerebral ischemia/reperfusion injury following cardiac arrest and cardiopulmonary resuscitation (CPR) has been demonstrated. Oxidant injury plays a critical role in the process. Since tea polyphenols from green tea are efficient free radical and singlet oxygen scavengers. We therefore sought to investigate if tea polyphenols would be effective in a rat model of asphyxial cardiac arrest.. Hypothesis: We hypothesized that tea polyphenols could reduce cerebral ischemia/reperfusion injury and consequently improve the outcome of CPR via counteracted the oxidant injury.. Methods: Male Sprague-Dawley rats, weighing 200-400 g, were induced cardiac arrest by clamping the trachyeal tubes. Cardiac arrest was determined by loss of aortic pulsations and mean aortic pressure , 10mmHg. At the end of 8 min of clamping, mechanical chest compression at a rate of 180/min was performed. Ventilation was started with room air at 70 breaths per min and tidal volume adjusted to 6 ml/kg. Epinephrine was ...
Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL...Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL...
Because polyphenols may have beneficial effects on dyslipidemia, which accelerates atherosclerosis in diabetes, we examined the effect of polyphenols on hepatocellular AMP-activated protein kinase (AMPK) activity and lipid levels, as well as hyperlipidemia and atherogenesis in type 1 diabetic LDL receptor-deficient mice (DMLDLR−/−). In HepG2 hepatocytes, polyphenols, including resveratrol (a major polyphenol in red wine), apigenin, and S17834 (a synthetic polyphenol), increased phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase (ACC), and they increased activity of AMPK with 200 times the potency of metformin. The polyphenols also prevented the lipid accumulation that occurred in HepG2 cells exposed to high glucose, and their ability to do so was mimicked and abrogated, respectively, by overexpression of constitutively active and dominant-negative AMPK mutants. Furthermore, treatment of DMLDLR−/− mice with S17834 prevented the decrease in AMPK and ACC ...
Effect of the intake of liquids rich in polyphenols on blood pressure and fat liver deposition in rats submitted to high-fat...Effect of the intake of liquids rich in polyphenols on blood pressure and fat liver deposition in rats submitted to high-fat...
PALMISCIANO BEDE, Teresa et al. Effect of the intake of liquids rich in polyphenols on blood pressure and fat liver deposition in rats submitted to high-fat diet. Nutr. Hosp. [online]. 2015, vol.31, n.6, pp.2539-2545. ISSN 1699-5198. http://dx.doi.org/10.3305/nh.2015.31.6.8655.. Introduction: seeking better quality of life, the number of studies on functional foods and disease prevention is growing fast. Whole red grape juice (WRGJ) and red wine (RW) stand out, which are rich in polyphenols, showing antioxidant and anti-inflammatory activity. Objective: to evaluate the effect of WRGJ and RW intake and resveratrol solution (RS) on blood pressure and fat liver deposition of rats fed with high-fat diet. Material and Methods: during 60 days, 50 Rattus norvegicus Wistar Albino adults were divided into: control group (CG) - balanced diet, hyperlipidic group (HG), red wine group (RWG), grape juice group (JGG) and resveratrol group (RG) - hyperlipidic diet. Feed and water were offered ad libttum to all ...
p38 Mitogen-Activated Protein Kinase Activates eNOS in Endothelial Cells by an Estrogen Receptor α-Dependent Pathway in...p38 Mitogen-Activated Protein Kinase Activates eNOS in Endothelial Cells by an Estrogen Receptor α-Dependent Pathway in...
In this study we found that ERα plays a key role in mediating the activation of eNOS in response to black tea polyphenols. In particular, we found that ERα is phosphorylated on Ser-118 in response to black tea polyphenol-mediated p38 MAPK activation. This ERα phosphorylation is required for p38 MAPK downstream signaling to Akt and eNOS that mediates black tea polyphenol-induced eNOS activation. We were able to implicate Ser-118 as a critical residue in this process as we observed ERα Ser-118 phosphorylation in response to black tea polyphenols and mutation of this residue abrogated polyphenol-induced eNOS activation in COS cells. This residue also appeared important for the functional association of p38 MAPK with ERα as mutants lacking this site did not associate with p38 MAPK in response to black tea polyphenols. These data suggest a novel adaptor function of ERα that integrates p38 MAPK signaling with downstream targets.. The rapidity of the response to black tea polyphenols suggests a ...
PolyphenolsPolyphenols
... are a diverse group of phytonutrients that determine colours of the fruits and vegetables, and protect the plants from diseases and invasion of external microorganisms. In fact, polyphenols are a part of defense mechanisms of the plants.. Polyphenols are classified into two major groups, flavonoids and phenolic compounds. A subtype of phenolic compounds is lignans, which are one of the major subclasses of phytoestrogens as well.. See "Flavonoids" and "Phenolic Compounds".. ...
Absorption, Distribution, and Elimination of Tea Polyphenols in Rats | Drug Metabolism & DispositionAbsorption, Distribution, and Elimination of Tea Polyphenols in Rats | Drug Metabolism & Disposition
The possible cancer-preventive activity of tea is receiving a great deal of attention. Information on the bioavailability and disposition of tea polyphenols such as EGCG, EGC, and EC is important for understanding the biological effects of tea. To our knowledge, this is the first report on the absorption, distribution, and elimination of EGCG, EGC, and EC in rodents that have been used extensively in the studies of cancer chemoprevention. Although there are similarities in their chemical structures (fig. 1), EGCG, EGC, and EC displayed different pharmacokinetics. When DGT was used as the source of tea polyphenols by i.v. injection, the K12 andK21 (the distribution rate constants between the central compartment and the peripheral compartment) were similar for EGC and EC. But for EGCG, the K12 was 3-fold larger than K21, suggesting that EGCG tends to distribute into the peripheral compartment (table 1). The longert1/2β and smaller CL of EGCG also indicate that EGCG could stay in the body for a ...
Antioxidants | Free Full-Text | Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of...Antioxidants | Free Full-Text | Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of...
Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese
Separation and Purification of Polyphenols from Pericarpium Granati Using Macroporous Resins and Evaluation of its Anti...Separation and Purification of Polyphenols from Pericarpium Granati Using Macroporous Resins and Evaluation of its Anti...
Abstract: Background: The optimal parameters of separation and purification of polyphenols from Pericarpium Granati were determined and the antibacterial activities against S. mutans in vitro were investigated. Methodology: Through comparing the static adsorption/desorption properties of five kinds of tested macroporous resins for polyphenols, HPD-450 resin was selected to investigate optimal purification parameters by dynamic curve experiments. The optimal purification conditions as follows: 9.0 BV of feeding solution at concentration of 3.2 mg mL 1 through the column at 3.0 BV h 1, then for desorption 60% ethanol-aqueous 3.5 BV at 2.0 BV h 1 eluted. The content of polyphenols was increased from 34.9±1.6% to 71.1±3.1% with a recovery yield of 85.5±3.7% according to the optimal parameters. Results: The present study showed that the MIC of purity of polyphenols was 6.25 mg mL 1. The acidogenicity of S. mutans can be significantly inhibited when the concentration was up to or higher than 1.56 ...
Chemopreventive potential of dietary polyphenols. - Surrey Research Insight Open AccessChemopreventive potential of dietary polyphenols. - Surrey Research Insight Open Access
The chemopreventive potential of a wide variety of structurally diverse polyphenols were initially evaluated for their apoptotic-inducing activity, using HCT-8 ileocecal adenocarcinoma cells. Apoptosis was measured by fluorescence microscopy and morphological criteria. (-)-Epigallocatechin-3-gallate (EGCG), theaflavins, curcumin and the grape seed polymer were found to be the most potent inducers of apoptosis, at concentrations physiologically relevant to humans. In contrast to the observation in HCT-8 cancerous cells, polyphenol-induced apoptosis was substantially lower in ICE-6 non-cancerous epithelial cells. The aforementioned "active" apoptotic polyphenols were subsequently assessed for their ability to activate direct and indirect caspases. Activation of downstream caspase- 3 and -7, and upstream caspase-9, in HCT-8 cells, implies that an intrinsic (intracellular) caspase cascade is involved in polyphenol-induced apoptosis. Potential pro-oxidant and/or antioxidant mechanisms and ...
Green tea polyphenols and 1-α-OH-vitamin D |sub|3|/sub| attenuate chronic inflammation-induced myocardial fibrosis in female...Green tea polyphenols and 1-α-OH-vitamin D |sub|3|/sub| attenuate chronic inflammation-induced myocardial fibrosis in female...
Fingerprint Dive into the research topics of Green tea polyphenols and 1-α-OH-vitamin D ,sub,3,/sub, attenuate chronic inflammation-induced myocardial fibrosis in female rats. Together they form a unique fingerprint. ...
Oral administration of copper to rats leads to increased lymphocyte cellular DNA degradation by dietary polyphenols:...Oral administration of copper to rats leads to increased lymphocyte cellular DNA degradation by dietary polyphenols:...
To account for the observed anticancer properties of plant polyphenols, we have earlier proposed a mechanism which involves the mobilization of endogenous copper ions by polyphenols leading to the gen
Figure 6 | Antioxidant, Cytotoxic, and Antiproliferative Activities and Total Polyphenol Contents of the Extracts of...Figure 6 | Antioxidant, Cytotoxic, and Antiproliferative Activities and Total Polyphenol Contents of the Extracts of...
Figure 6: Antioxidant, Cytotoxic, and Antiproliferative Activities and Total Polyphenol Contents of the Extracts of |i|Geissospermum reticulatum|/i| Bark
Green tea polyphenols thwart prostate cancer development at multiple levels | EurekAlert! Science NewsGreen tea polyphenols thwart prostate cancer development at multiple levels | EurekAlert! Science News
The polyphenols present in green tea help prevent the spread of prostate cancer by targeting molecular pathways that shut down the proliferation and spread of tumor cells, as well as inhibiting the growth of tumor nurturing blood vessels, according to research published in the December 1 issue of Cancer Research.
The polyphenol delphinidin induces antioxidant effects in human umbilical vein endothelial cells through activation of...The polyphenol delphinidin induces antioxidant effects in human umbilical vein endothelial cells through activation of...
TY - JOUR. T1 - The polyphenol delphinidin induces antioxidant effects in human umbilical vein endothelial cells through activation of endogenous glutathione: importance of using relevant concentration in in vitro systems. AU - Goszcz, Katarzyna. AU - Duthie, Garry. AU - Stewart, Derek. AU - Megson, Ian. N1 - © 2017, Published by the BMJ Publishing Group Limited.. PY - 2017/4/1. Y1 - 2017/4/1. N2 - Polyphenols are regarded to have a wide range of health-promoting effects. Increased consumption of polyphenol-rich food is known to be associated with numerous cardioprotective effects. Polyphenols have been shown to improve endothelial function, inhibit abnormal platelet aggregation, reduce inflammation and improve plasma lipid profiles. Moreover, polyphenols have been widely recognised as powerful antioxidants. Given that oxidative stress plays a key role in initiation and progression of atherosclerosis, antioxidant therapy with polyphenols has potential. However, the concentrations required to ...
Plant Polyphenols Dont Help Heart Health - AnabolicMinds.comPlant Polyphenols Don't Help Heart Health - AnabolicMinds.com
Research has called into question the role of plant polyphenols in cardiovascular health, by finding that their supposed anti-platelet activities are only relevant at high, and physiologically unattainable, concentrations.
IJMS | Free Full-Text | Modulatory Effects of Polyphenols on Apoptosis Induction: Relevance for Cancer PreventionIJMS | Free Full-Text | Modulatory Effects of Polyphenols on Apoptosis Induction: Relevance for Cancer Prevention
Polyphenols, occurring in fruit and vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products, have been demonstrated to have clear antioxidant properties in vitro, and many of their biological actions have been attributed to their intrinsic reducing capabilities. However, it has become clear that, in complex biological systems, polyphenols exhibit several additional properties which are yet poorly understood. Apoptosis is a genetically controlled and evolutionarily conserved form of cell death of critical importance for the normal embryonic development and for the maintenance of tissue homeostasis in the adult organism. The malfunction of the death machinery may play a primary role in various pathological processes, since too little or too much apoptosis can lead to proliferative or degenerative diseases, respectively. Cancer cells are characterized by a deregulated proliferation, and/or an inability to undergo programmed cell death. A large body of evidence indicates that
Wine Polyphenols Decrease Blood Pressure, Improve NO Vasodilatation, and Induce Gene Expression | HypertensionWine Polyphenols Decrease Blood Pressure, Improve NO Vasodilatation, and Induce Gene Expression | Hypertension
The present study shows that oral administration of RWPC from 2 different sources (ie, Provinol and RWPC1) to the rat modifies hemodynamic parameters and vascular reactivity. In vivo treatment of normotensive rats with RWPC decreased arterial blood pressure without any change in heart rate. In addition, RWPC treatment is associated with changes in the vascular reactivity of the thoracic aorta. RWPC treatment enhanced endothelium-dependent relaxation in response to acetylcholine but also induced increased expression of COX-2 with subsequent increased release of endothelial thromboxane A2 (TXA2), which opposes the NO-induced hyporeactivity of the aorta to norepinephrine, which is consequent on increased iNOS expression.. In previous studies, we reported that RWPCs from both Provinol and RWPC1 were able to produce ex vivo endothelium-dependent relaxation in rat aortic rings as a result of enhanced NO synthesis.11,12 The present study provides evidence that in vivo administration of these 2 sources ...
Top 5 Foods Rich In Polyphenols | BlgrTop 5 Foods Rich In Polyphenols | Blgr
To feel young and look great at any age is the ultimate in anti-aging. It really is possible to attain that fountain of youth if you eat the right foods on a daily basis, drink plenty of refreshing beverages, exercise, and stay as stress-free as possible. There is a myriad of health foods popping up in the market. Most of them are helpful, but if you want to cut to the chase…Just what are the right foods? The ones that are packed with anti-aging molecules that can keep you young forever?. Foods rich in polyphenols can slow down the aging process. And, there are some studies that show that polyphenols may even reverse the effects of aging. Youve heard much about three of these top 5 foods, but theres two more you didnt think about as top health foods. Herea a delicious list of the top 5 foods to keep young.. Green Tea: Drink 2 or 3 cups of green tea daily for maximum health and beauty benefits.. Blueberries: Blueberries help your circulation and help prevent atherosclerosis; they improve ...
A new role for milk: Delivering polyphenols with anti-cance... ( Philadelphia PA December 19 2013 Po...)A new role for milk: Delivering polyphenols with anti-cance... ( Philadelphia PA December 19 2013 Po...)
...Philadelphia PA December 19 2013 Polyphenols found in tea manifest... These results support a new role for milk as an ideal platform for de...The majority of extractable polyphenols in tea are flavan-3-ols commo...In one experiment human colorectal cancer cells (HT-29) were grown fo...,A,new,role,for,milk:,Delivering,polyphenols,with,anti-cancer,activity,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Beneficial effect of a polyphenol-rich diet on cardiovascular risk: a randomised control trial | HeartBeneficial effect of a polyphenol-rich diet on cardiovascular risk: a randomised control trial | Heart
The PPhIT study aimed to extend a previous dietary intervention (FAVRIT) that had been shown to improve microvascular function in hypertensive subjects. This study develops those findings by showing that increasing polyphenol content with the addition of berries and dark chocolate potentially has additional benefits on microvascular function and CVD risk. The ideal combination of polyphenol-rich foods for cardiovascular health remains under debate. It was hypothesised that this diet would provide increased benefits to cardiovascular health and, importantly, given its palatability, be easily adopted by the general public.. The primary endpoint of the PPhIT study was between-group change in maximum FBF response to the endothelium-dependent vasodilator, ACh. Between-group comparison showed that those subjects who received a high-polyphenol diet had a significantly greater improvement in maximum % response to ACh, compared with the low-polyphenol group (p=0.02). This suggests that increasing ...
AMICOR: PolyphenolsAMICOR: Polyphenols
To refresh organic chemistry-challenged minds, polyphenols are characterized by the presence of multiple phenolic rings (ie, benzene rings with hydroxyl groups). They are produced by plants to defend against ultraviolet radiation or pathogens. Polyphenols are responsible for some of the color, flavor, odor, and bitterness of fruits, vegetables, grains, and such beverages as tea and coffee. They function as antioxidants and have been reported to bestow health benefits, including protection from cardiovascular disease, cancer, infections, and a variety of other conditions ...
Polyphenols may slash heart disease riskPolyphenols may slash heart disease risk
Increased intakes of polyphenols may reduce the risk of cardiovascular disease by an impressive 46%, according to the results of the international PREDIMED (Prevencion con Dieta Mediterranea) study.
polyphenols rich foods with no lectins | How To Cure Diabetes Naturallypolyphenols rich foods with no lectins | How To Cure Diabetes Naturally
How to boost your intake of polyphenol antioxidants. polyphenols have wiki how to boost your intake of polyphenol eat and drink polyphenol-rich foods. These
CHEMOPREVENTIVE EFFECT OF HASKAP BERRY POLYPHENOLS AGAINST TOBACCO SPECIFIC NITROSAMINE-INDUCED DNA DAMAGE IN NORMAL LUNG...CHEMOPREVENTIVE EFFECT OF HASKAP BERRY POLYPHENOLS AGAINST TOBACCO SPECIFIC NITROSAMINE-INDUCED DNA DAMAGE IN NORMAL LUNG...
The protective effect of polyphenol-rich haskap berry extracts against tobacco-specific nitrosamine ketone (NNK)-induced DNA damage was studied in vitro. Normal lung epithelial BEAS-2B cells were exposed to NNK, and to its precursor, 4-[(acetoxymethyl) nitrosamino]-1-(3-pyridyl)-1-butanone (NNKOAc), to induce DNA damage. Polyphenols present in haskap berries were extracted using ethanol and water, separately. Quercetin-3-O-glucoside (Q3G) and cyanidin-3-O-glucoside (C3G) were used as the reference compounds. BEAS-2B cells were pre-incubated with non-cytotoxic concentrations of haskap extracts, Q3G, and C3G separately, and investigated for their protective effects against NNK- and NNKOAc-induced DNA damage. Pre-incubation of BEAS-2B cells with haskap extracts, Q3G, and C3G, significantly suppressed the NNK- and NNKOAc-induced DNA strand breaks, and intracellular reactive oxygen species generation. The protective effect of haskap extracts could be related to their polyphenol content and high ...
7 Potential Benefits of Apple Polyphenols - SelfHacked7 Potential Benefits of Apple Polyphenols - SelfHacked
The antioxidant polyphenols in apple skin may reduce inflammation and improve heart & gut health. Read on to discover how apples can help you.
Protein powder comparative amino acid analysis - Page 9 - Vegan Bodybuilding & FitnessProtein powder comparative amino acid analysis - Page 9 - Vegan Bodybuilding & Fitness
A new protein is coming to town and it is something every bodybuilder is going to want to try. The secret to this new protein is something called polyphenols, which are plant extracts that are known to help increase the bodys own fat burning effect. Polyphenols can be found in many plant varieties, but some of the most potent come from tea extracts like green and black tea. These polyphenols are proven to help the body burn more fat calories per workout and to keep burning fat all day long. Unfortunately you need to drink a lot of green tea to get the full fat burning effects or take a green tea supplement three times per day. However, a new protein source is now available that contains natural polyphenols similar to what is found in green tea and is proven in scientific literature to increase the fat burning effect in the bodys mitochondria. This is the holy grail of all protein supplements, to be able to burn fat while promoting lean muscle growth and it is finally available. Lipotropic ...
Polyphenols Antioxidant Glitter is Not Gold for AllPolyphenols' Antioxidant Glitter is Not Gold for All
June 29, 2010. Polyphenols antioxidant health benefits may come at a cost to some people. Penn State researchers found that eating certain polyphenols decreases the amount of iron the body absorbs, which can increase a persons risk for developing iron deficiency. The researchers, led by Dr. Okhee Han, assistant professor of nutritional sciences, studied the effects of eating several polyphenols: grape seed extract and EGCG (epigallocatechin-3-gallate), which is found in green tea.. "Polyphenols have been known to have many beneficial effects for human health, such as preventing or delaying certain types of cancer, enhancing bone metabolism, decreasing risk of heart disease, and improving bone mineral density," says Han. "But so far, not many people have thought about whether or not polyphenols affect nutrient absorption.". The researchers used cells derived from the intestine-where iron absorption takes place-to assess the polyphenols impact. They found that polyphenols bind to iron molecules ...
Pycnogenol joint health benefits illuminated in unique trialPycnogenol joint health benefits illuminated in unique trial
The Wurzburg-based scientists recruited 33 individuals diagnosed with severe osteoarthritis scheduled for knee replacement surgery (arthroplasty). The volunteers were supplemented with 200 mg per day of Pycnogenol or no supplements (control group) for three weeks leading up to their scheduled surgeries, and synovial fluid samples were collected during surgery to detect and measure the presence of polyphenols.. Results showed that the polyphenols found in Pycnogenol including taxifolin, ferulic acid and catechin were distributed throughout the synovial fluid. On the other hand, taxifolin and ferulic acid were not detected in control group serum samples.. "To the best of our knowledge, this is the first study investigating polyphenol concentrations in human synovial fluid samples of patients with osteoarthritis. Similar to the results of serum analysis, mean polyphenol concentrations were similar in the [Pycnogenol] and [control] groups, but taxifolin was only detectable in the [Pycnogenol] group. ...
Barley Malt Treated with Enzymes Increases Polyphenol Content and Antioxidant Activity | Korea ScienceBarley Malt Treated with Enzymes Increases Polyphenol Content and Antioxidant Activity | Korea Science
Barley Malt Treated with Enzymes Increases Polyphenol Content and Antioxidant Activity - Barley malt;Malting period;Enzymatic treatment;Antioxidant;Total polyphenol;
Polyphenols/OPCs - Vegan - Country Life - Swanson Health ProductsPolyphenols/OPCs - Vegan - Country Life - Swanson Health Products
Shop the best Polyphenols/OPCs - Vegan - Country Life products at Swanson Health Products. Trusted since 1969, we offer trusted quality and great value on Polyphenols/OPCs - Vegan - Country Life products.
Polyphenols/OPCs - Seagate - Swanson Health ProductsPolyphenols/OPCs - Seagate - Swanson Health Products
Shop the best Polyphenols/OPCs - Seagate products at Swanson Health Products. Trusted since 1969, we offer trusted quality and great value on Polyphenols/OPCs - Seagate products.
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Experimental studies have reported on the anti-inflammatory properties of polyphenols. However, results from epidemiological investigations have been inconsistent, and especially studies using biomarkers for assessment of polyphenol intake have been scant. We aimed to characterize the association between plasma concentrations of 35 polyphenol compounds and low-grade systemic inflammation state as measured by high-sensitivity C-reactive protein (hsCRP). A cross-sectional data analysis was performed based on 315 participants in the European Prospective Investigation into Cancer and Nutrition cohort with available measurements of plasma polyphenols and hsCRP. In logistic regression analysis the odds and 95% confidence intervals (CI-s) of elevated serum hsCRP (,3 mg/L) were calculated within quartiles and per standard deviation (SD) higher level of plasma polyphenol concentrations. In multivariable-adjusted model, the sum of plasma concentrations of all polyphenols measured (per SD) was associated ...
Antioxidant effect of polyphenols and natural phenols - WikipediaAntioxidant effect of polyphenols and natural phenols - Wikipedia
A polyphenol antioxidant is a type of antioxidant containing a polyphenolic substructure. Numbering over 4,000 distinct species, many of these compounds have antioxidant activity in vitro but are unlikely to have antioxidant roles in vivo. Rather, they may affect cell-to-cell signaling, receptor sensitivity, inflammatory enzyme activity or gene regulation. From about 500 million years ago, freshwater and terrestrial plants slowly optimized the production of "new" endogenous antioxidants, such as ascorbic acid (vitamin C), natural phenols (including flavonoids) and polyphenols, tocopherols, etc.[citation needed] A few of these appeared more recently, in the last 50-200 million years, in fruits and flowers of angiosperm plants. In fact, the angiosperms (the flowering plants), the dominant type of plant today (and most of their antioxidant pigments) evolved during the late Jurassic period. The main source of polyphenols is dietary, since they are found in a wide array of phytochemical-bearing ...
Global Tea Polyphenols Market Size & Share | Industry Report, 2020Global Tea Polyphenols Market Size & Share | Industry Report, 2020
Growing consumer awareness regarding various health benefits offered by tea polyphenols has been acting as one of the major factors driving their market
Effect of a diet enriched in PUFA and polyphenols on the expression of genes involved in lipids metabolism in pigs | Archivio...Effect of a diet enriched in PUFA and polyphenols on the expression of genes involved in lipids metabolism in pigs | Archivio...
The content of saturated, monounsaturated and polyunsaturated fatty acids (FA) in pig muscle is very important not only for the consumers health but also for the pig processing industry. Breed, diet and genetics are the main factors controlling FA composition of pig meat even if molecular processes and genes controlling lipids metabolism are not yet well known. We performed the present study to improve the knowledge of diet influence on the transcription of genes controlling lipids metabolism. The effects on gene expression of a diet enriched in polyunsaturated fatty acids (PUFA) and polyphenols vs. a control diet were compared. The transcription level of 30 genes involved in FA metabolism and fat deposition in pigs was analysed. Two groups of 12 Italian Large White pigs each, balanced for sex, were reared until the average weight of 149 kg (±10.7 kg). The first group (G1) was fed a standard diet while for the second group (G2) the diet was supplemented with linseed and grape extract. Samples ...
Publication : USDA ARSPublication : USDA ARS
DOI: https://doi.org/10.3945/cdn.117.001115 Interpretive Summary: Polyphenols are natural plant products found in fruits, vegetables, coffee, tea, wine and chocolate that might help reduce body weight and body fat. Hispanics/Latinos have high rate of obesity but little is known how polyphenols might relate to their body mass index and body fat. We recruited 442 Hispanics/Latinos into the study at four study sites: Chicago, Illinois; Miami, Florida; Bronx, New York; and San Diego, California. In the study, we measured their body mass index based on weight and height and their body fat using a standard stable isotope dilution method. Their polyphenol intakes were based on the amounts of polyphenols found in their urine samples collected over a 24-hour period. The study showed that for every 50% increase in one of the polyphenols, urolithin A, there was a 0.4-unit decrease in body mass index. For every 50% increase in two of the polyphenols, resveratrol and urolithin A, there was a 1% and 0.4% ...
Polyphenol Metabolome in Human Urine and Its Association With Intake of Polyphenol-Rich Foods Across European Countries - PubMedPolyphenol Metabolome in Human Urine and Its Association With Intake of Polyphenol-Rich Foods Across European Countries - PubMed
Highly diverse food-derived metabolites (the so-called food metabolome) can be characterized in human biospecimens through this powerful metabolomic approach and screened to identify novel biomarkers for dietary exposures, which are ultimately essential to better understand the role of the diet in t …
Plus itPlus it
Recently, squamous cell carcinoma of the head and neck chemoprevention research has made major advances with novel clinical trial designs suited for the purpose, use of biomarkers to identify high-risk patients, and the emergence of numerous molecularly targeted agents and natural dietary compounds. Among many natural compounds, green tea polyphenols, particularly (−)-epigallocatechin-3-gallate (EGCG), possess remarkable potential as chemopreventive agents. EGCG modulates several key molecular signaling pathways at multiple levels and has synergistic or additive effects when combined with many other natural or synthetic compounds. This review will provide an update of the potential of green tea polyphenols, particularly EGCG, for the chemoprevention of squamous cell carcinoma of the head and neck. Cancer Prev Res; 3(8); 900-9. ©2010 AACR. ...
Supplementation With Polyphenol-Rich Foods and Atrial Fibrillation After a Cardiac Surgery - No Study Results Posted -...Supplementation With Polyphenol-Rich Foods and Atrial Fibrillation After a Cardiac Surgery - No Study Results Posted -...
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
Green Tea Polyphenols Induce Differentiation and Proliferation in Epidermal Keratinocytes | Journal of Pharmacology and...Green Tea Polyphenols Induce Differentiation and Proliferation in Epidermal Keratinocytes | Journal of Pharmacology and...
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Green Tea Polyphenols as Acetylcholinesterase Inhibitors for Memory ImprovementGreen Tea Polyphenols as Acetylcholinesterase Inhibitors for Memory Improvement
Life Enhancement Products, an innovative manufacturer of nutritional supplements with unique formulations for memory enhancement, blood sugar maintenance, thyroid support, weight control, gastrointestinal support, and more.
Fanatic Cook: Bucketfuls of PolyphenolsFanatic Cook: Bucketfuls of Polyphenols
Polyphenols is a broad term encompassing lots of more specific plant chemicals (phytochemicals), including the flavonoids (e.g. quercetin), tannins (in tea and wine) and others known to have tremendous anti-cancer, anti-heart-disease, antioxidant, and, at least according to Pliny the Elder, wrinkle-smoothing abilities. So polyphenols is a bucket term, and boy do figs have bucketfuls ...
Apple Polyphenols and Longevity - page 1 - Life ExtensionApple Polyphenols and Longevity - page 1 - Life Extension
Scientists at three different labs have found that the use of apple polyphenols increased the life span of various species by 10 to 12%.
DIGITAL.CSIC: Polyphenols associated with dietary fibre in wine. A wine Polyphenols gap?DIGITAL.CSIC: Polyphenols associated with dietary fibre in wine. A wine Polyphenols gap?
The presence of polyphenolic compounds associated with dietary fibre is a characteristic feature of polyphenol-rich plant foods. It was recently reported that soluble dietary fibre is a common constituent of wine. The objective of this work was to ascertain whether significant amounts of wine polyphenols are associated with dietary fibre. Total phenolics, antioxidant capacity, and HPLC analysis were determined in wines and in corresponding dietary fibre solutions obtained after enzymatic treatments and dialysis. Results showed that 35-60% of total polyphenols in red wine and about 9% in white wine are associated with dietary fibre. These polyphenols are not detected by the usual HPLC analytical techniques and consequently may be ignored in most chemical and biological studies - what we call ,the wine polyphenols gap,. Our findings suggest that a significant part of wine polyphenols are not bioaccesible in the human small intestine and reach the colon along with dietary fibre. © 2006 Elsevier ...
Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and...Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and...
TY - JOUR. T1 - Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. AU - Lee, Hsin Hsueh. AU - Yang, Ling-Ling. AU - Wang, Ching Cheung. AU - Hu, Ssu Yao. AU - Chang, Shwu Fen. AU - Lee, Yi-Hsuan. PY - 2003/10/3. Y1 - 2003/10/3. N2 - Neuronal injury in the central nervous system following ischemic insult is believed to result from glutamate toxicity and glucose deprivation. In this study, polyphenols isolated from Scutellaria baicalensis Georgi, including baicalin, baicalein, and wogonin, were investigated for their neuroprotective effects against glutamate/NMDA (Glu/NMDA) stimulation and glucose deprivation in primary cultured rat brain neurons. Cell death was accessed by lactate dehydrogenase (LDH) release assay for necrosis, and mitochondrial activity was accessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction activity assay. It was found that ...
Hunan NutraMax Inc.公司提供的Green Tea Polyphenols -- 食品、飲料與營養保健品Hunan NutraMax Inc.公司提供的Green Tea Polyphenols -- 食品、飲料與營養保健品
Green Tea Polyphenols are chemical compounds which are found naturally in tea, similar to flavonoids and tannins. This product can reduce the risk of d...
Green Tea Polyphenol Administration Partly Ameliorates Chemotherapy-Induced Side Effects in the Small Intestine of Mice | Herb...Green Tea Polyphenol Administration Partly Ameliorates Chemotherapy-Induced Side Effects in the Small Intestine of Mice | Herb...
The chemotherapy agent irinotecan is highly effective against several types of cancer, but its use is limited due to severe intestinal toxicity. Green tea polyphenols (1 g per liter) used for seven days before and three days after treatment reduced the toxicity. "Green tea polyphenols supplied orally protected against oxidation in our experimental model and could be one approach to reducing the risk of chemotherapy induced side effects in a clinical setting.". The chemotherapeutic agent irinotecan (IT) is highly effective against several types of cancer, although its use is limited due to severe intestinal toxicity. The aim of this study was to evaluate inflammatory and oxidative stress-related processes contributing to small intestinal mucosa damage and to determine the extent to which green tea polyphenols could ameliorate the detrimental effects induced by IT. In Expt. 1, mice were challenged intraperitoneally with IT or saline on 2 consecutive days. For time kinetic measurements, the ...
Polyphenols offer promise for rosacea symptoms : Rosacea Support GroupPolyphenols offer promise for rosacea symptoms : Rosacea Support Group
The Role of Polyphenols in Rosacea Treatment: A Systematic Review. The Journal of Alternative and Complementary Medicine. June 2017, ahead of print. Objectives: Various treatment options are available for the management of rosacea symptoms such as facial erythema, telangiectasia, papules and pustules, burning, stinging, and itching. Botanical therapies are commonly used to treat the symptoms. The objective of this review is to evaluate the use of polyphenols in rosacea treatment.. Design: PubMed, Embase, Biosis, Web of Knowledge, and Scopus databases were systematically searched for clinical studies evaluating polyphenols in the management of rosacea.. Results: Of 814 citations, 6 met the inclusion criteria. The studies evaluated licochalcone (n = 2), silymarin (n = 2), Crysanthellum indicum extract (n = 1), and quassia extract (n = 1). The studies only evaluated topical formations of stated polyphenols. Main results were summarized.. Conclusions: There is evidence that polyphenols may be ...
Comparative effects of selected plant polyphenols, gallic acid and epigallocatechin gallate, on matrix metalloproteinases...Comparative effects of selected plant polyphenols, gallic acid and epigallocatechin gallate, on matrix metalloproteinases...
The aim of the study was to investigate the effect of selected polyphenols: gallic acid (GA) and epigallocatechin gallate (EGCG) on matrix metalloproteinase (MMP-2 and MMP-9) activity in multidrug resistant (MDR) human breast adenocarcinoma cells: MCF7/DOX cells and obtained recently in our laboratory MCF7/DOX500 cells by the permanent selection of MCF7/DOX cells with 500 nM doxorubicin (DOX). The activity of MMP-2 and MMP-9 and the effect of studied polyphenols on these matrix proteases were examined by gelatin zymography assays. We have found that the activity of MMP-2 and MMP-9 significantly increased in resistant MCF7/DOX and MCF7/DOX500 cells whereas they were not detected in sensitive MCF7 cells. It was also observed that GA (30, 60, 100 and 120 µM) and EGCG (5, 10 and 20 µM) caused a comparable concentration-dependent inhibition of MMP-2 and MMP-9 activity in MCF7/DOX and MCF7/DOX500 cells. Control experiments confirmed that examined compounds in these ranges of concentration did not ...
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Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of | The Dr. Rath Health FoundationUrinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of | The Dr. Rath Health Foundation
Sun CL, Yuan JM, Lee MJ, Yang CS, Gao YT, Ross RK, Yu MC. USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA. [email protected] Experimental studies have shown that tea and tea polyphenols have anticarcinogenic properties. There have been no prospective investigations examining the relationship between tea polyphenols and cancer risk using validated biomarkers. In the present study, a nested case-control study design was used to investigate the association between prediagnostic urinary tea polyphenol markers and subsequent risk of gastric and esophageal cancers. One hundred and ninety incident cases of gastric cancer and 42 cases of esophageal cancer occurring in members of the Shanghai Cohort (18 244 men aged 45-64 years at recruitment with up to 12 years of follow-up) were compared with 772 cohort control subjects. The control subjects were individually matched to the index cases by age, ...
Tea | Herb News | Page 4Tea | Herb News | Page 4
Research in stroke-prone spontaneously hypertensive rats demonstrated benefits from both black and green tea polyphenols. Oxidative stress is reportedly involved not only in cardiovascular disease but also in hypertension. Using continuous monitoring of blood pressure, both green tea polyphenols and black tea polyphenols significantly reduced both systolic and diastolic blood pressure compared with controls. "These […]. ...
EduFacts Scientific Write-ups - Polyphenols Bolster Drug Effects in Ocular HypertensionEduFacts Scientific Write-ups - Polyphenols Bolster Drug Effects in Ocular Hypertension
Polyphenols Bolster Drug Effects in Ocular Hypertension Ocular Hypertension and Risk of Glaucoma Ocular hypertension is a leading risk factor for the development of primary open angle glaucoma (POAG), and is the only modifiable risk factor acknowledged at present. Its estimated that 4 to 7% of Americans over 40 years of age have ocular hypertension. The Ocular Hyper-tension Treatment Study (OHTS) clearly showed that lowering IOP is effective in delaying or preventing the onset of POAG in individuals with ocular hypertension. Recent results from a long-term study by the OHTS group indicates that those at high risk of POAG can benefit from early preventive treatment (1). Spurred by previous findings that a combination of polyphenols (anthocyanins and procyanidins) could improve IOP and blood flow in ocular hypertension, the same researchers recently compared the effects of those polyphenols alone and with latanoprost in ocular hypertensive patients with no signs of POAG (2). Study Design The ...
arterial compliancearterial compliance
HESPERIDIN IN ORANGE JUICE IMPROVES HYPERTENSION AND ARTERIAL FUNCTION. Polyphenols are chemical compounds that are found in most of the plant-based foods that we commonly eat. As I discuss in detail in my new book, A Cancer Prevention Guide for the Human Race, some polyphenolic compounds, such as green tea flavonoids, soy-based isoflavones, quercetin, curcumin, and resveratrol, among other polyphenols, may possess important cancer prevention properties. There is also abundant research data suggesting that diets rich in certain natural dietary polyphenols may be associated with a decreased risk of cardiovascular disease, as well.. Hesperidin, which is a flavonoid polyphenol, is found in a variety of plant-based foods, including oranges, orange juice, and other citrus fruits. A newly published prospective, randomized, blinded clinical research study, which appears in the current issue of the American Journal of Clinical Nutrition, offers intriguing evidence that hesperidin may actually decrease ...
Black tea polyphenols reverse epithelial-to-mesenchymal transition and suppress cancer invasion and proteases in human oral...Black tea polyphenols reverse epithelial-to-mesenchymal transition and suppress cancer invasion and proteases in human oral...
Epithelial-to-mesenchymal transition (EMT) in cancer cells is considered to be a prerequisite for acquiring invasive/migratory phenotype and subsequent metastasis. This study provides molecular evidence associated with the antimetastatic effect of black tea polyphenol extracts (BTE), which contain p …
multiwalled carbon nanotubes/tea polyphenols compositemultiwalled carbon nanotubes/tea polyphenols composite
Page contains details about multiwalled carbon nanotubes/tea polyphenols composite . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols | PNASInhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols | PNAS
Limited available options for the treatment of CaP and its increasing incidence have spurred the search for novel preventive approaches for the management of this disease. Chemoprevention by the use of dietary agents or synthetic compounds could be one such strategy that may block the neoplastic inception or delay disease progression (4-6). Because CaP is typically diagnosed in men aged 50 years and older, even a slight delay in the onset and subsequent progression of the disease through the use of chemopreventive agent(s) could have important health benefits. Ideally, the efficacy of such chemopreventive agents should be verified in animal models that emulate human disease before recommending their use for humans. The most notable implication of our work is that oral infusion of a human-achievable dose of green tea results in significant inhibition in development and progression of CaP along with increased survival in an animal model that emulates human disease. These data, therefore, suggest ...
GREENSELECT® PHYTOSOME® - IndenaGREENSELECT® PHYTOSOME® - Indena
Green Tea (Camellia sinensis) extract is extremely rich in biologically active polyphenols, the most representative of which is Epigallocatechin 3-O gallate (EGCG), but it also contains other polyphenols belonging to the same chemical group. When topically applied on the skin in human clinical testing, green tea polyphenols have been reported to prevent UVB induced redness and DNA challenge.. ...
A Cost-Effective Solution To Partially Replace Vitamin E - Agriculture MonthlyA Cost-Effective Solution To Partially Replace Vitamin E - Agriculture Monthly
POLYPHENOLS CAN BE MORE EFFICIENT THAN VITAMIN E IN REDUCING OXIDATIVE PRESSURE. Vitamin E is not unique in its ability to neutralize free radicals. It belongs to a family of antioxidant compounds called polyphenols. Within this very diverse family, there are molecules that have a greater antioxidant capacity per gram than vitamin E.. Furthermore, some polyphenols have improved bioavailability. Thus, the improved activity and availability of some polyphenols result in a more effective antioxidant supply in livestock than vitamin E alone. STUDIES SHOW THAT FEED ADDITIVES CAN SAFELY REPLACE PART OF THE VITAMIN E REQUIREMENTS OF LIVESTOCK. Trouw Nutrition proved the efficacy of specifically selected polyphenols in both swine and poultry using a heat challenge model. Animals were fed either a negative control diet containing NRC-recommended levels of vitamin E, a positive control diet containing industry-standard levels of supplementation (above NRC), or a test diet in which the vitamin E above NRC ...
Green Tea - The Complete Guide • SupplementryGreen Tea - The Complete Guide • Supplementry
How Topical Extracts Have been Developed to Treat Skin Ailments. Green tea has also played a role in skin health by way of topical extracts. The polyphenols mentioned above act as antioxidants inside our body. They also have health benefits when topically applied. These polyphenols prevent inflammation and swelling, protect cartilage between bones, and lesson joint degeneration. Here are the 3 areas in which green tea can help your skin and organs grow and stay healthy.. 1) On-the-Surface Benefits: When applied topically, green tea can help prevent skin cancer by blocking toxic UV rays, and it works effectively in tandem with sunblock. Because of its rejuvenating properties as far as being an antioxidant and anti-inflammatory, it also makes sense that green tea is a great ointment for aging skin. Our trusty polyphenols are at work here too, slowing down the signs of aging by detoxifying.. 2) Healthy Cells: Growing evidence also shows that polyphenols in green tea extract can prevent many types ...
Is Red Wine Bad For Your Teeth? - Smile Makeover of LAIs Red Wine Bad For Your Teeth? - Smile Makeover of LA
Common knowledge teaches that drinking a glass of red wine at dinner is good for your health.. Common knowledge also once taught that the earth was flat.. The polyphenols in red wine were once believed to increase HDL cholesterol and strengthen artery linings. Those findings were based on studies interpreted through the lens of the lipid hypothesis, the dubious low-fat, low-cholesterol theory now in contention by the medical community. One particular polyphenol - resveratrol - reduced inflammation and risk of diabetes in mice. However, the Mayo Clinic pointed out that a human would have to chug 1,000 liters of red wine a day to ingest the same amount administered to the mice.. One study even suggests that red wine can improve oral hygiene. The theory supposes that the antioxidant polyphenols in red wine could half the formation of bacteria in the biofilm on teeth.. Yet the mouth of the recreational wine drinker may turn the color of old bruises, ranging from pale yellow to deep purple.. ...
Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines...Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines...
Background: Few clinical studies have focused on the alcoholindependent cardiovascular effects of the phenolic compounds of red wine (RW). Objective: We aimed to evaluate the effects of ethanol and phenolic compounds of RW on the expression of inflammatory biomarkers related to atherosclerosis in subjects at high risk of cardiovascular disease. Design: Sixty-seven high-risk, male volunteers were included in a randomized, crossover consumption trial. After a washout period, all subjects received RW (30 g alcohol/d), the equivalent amount of dealcoholized red wine (DRW), or gin (30 g alcohol/d) for 4 wk. Before and after each intervention period, 7 cellular and 18 serum inflammatory biomarkers were evaluated. Results: Alcohol increased IL-10 and decreased macrophage-derived chemokine concentrations, whereas the phenolic compounds of RW decreased serum concentrations of intercellular adhesion molecule- 1, E-selectin, and IL-6 and inhibited the expression of lymphocyte function-associated antigen 1 ...
Superfood Series - Pomegranate | The Good CalorieSuperfood Series - Pomegranate | The Good Calorie
Do you believe in the power of food? Or that food can prevent disease and strengthen your heart? One bright red fruit comes to mind when discussing the impact of food on heart health. Pomegranates!. Pomegranates are high in potassium, vitamin C and polyphenols. Potassium helps your body maintain a healthy blood pressure. Vitamin C and polyphenols act as antioxidants and protect your body from stress by preventing inflammation. Antioxidants help your immune system fight off damaging free radicals.. We know that the nutritional components of pomegranate juice are beneficial, but what about studies conducted on regular consumption of pomegranates? The scientific research regarding pomegranates is limited, but the findings are promising. Pomegranate juice has been shown to decrease blood pressure in hypertensive individuals over a 2 week period1. Due to the antioxidants and polyphenols found in the fruit, regular consumption may reduce the risk of developing cardiovascular disease2.. Pomegranates ...
Stilbenes - Healthy Facts | Information about Antioxidant Supplements and Anti-Aging NutritionStilbenes - Healthy Facts | Information about Antioxidant Supplements and Anti-Aging Nutrition
A phenolic acid is a sort of phytochemical known as a polyphenol. Phenolic acids are found in an assortment of plant-based nourishments such as the seeds and skins of products of the soil leaves of vegetables contain the most noteworthy concentration. Phenolic acids are promptly consumed through the dividers of your intestinal tract, and they might be valuable to your wellbeing since they fill in as cancer prevention agents that counteract cell harm because of free-radical oxidation responses. The Polyphenol phenolic acid supplements may likewise work as anti inflammatory in the human body. It strongly supports a role for polyphenols in the prevention of degenerative diseases, particularly cardiovascular diseases and cancers. The antioxidant properties of polyphenols have been widely studied, but it has become clear that the mechanisms of action of polyphenols go beyond the modulation of oxidative stress. Polyphenols are the most abundant antioxidants in the diet. Their total dietary intake ...
Baked blueberries may have altered polyphenol content warn researchersBaked blueberries may have altered polyphenol content warn researchers
Baking blueberries could lead to changes their polyphenol content, and alter the potential health benefits of the superfood, according to new research.
Most recent papers with the keyword Tea polyphenols | Read by QxMDMost recent papers with the keyword Tea polyphenols | Read by QxMD
The physicochemical properties of tea extracts are significantly affected by the extraction method. The aim of this study was to compare the effects of static and dynamic extractions on the concentrations of chemical components and taste quality of green tea extracts. Our results show that extraction of chemical components using static extraction follows a pseudo-second-order reaction, while that of dynamic extraction follows a first-order reaction. The concentrations of the solids, polyphenols, and free amino acids in green tea extract prepared by dynamic extraction were much higher, although the overall yields were not significantly different between the two extraction methods ...
Cancer Prevention by Tea Polyphenols Is Linked to Their Direct Inhibition of Antiapoptotic Bcl-2-Family Proteins | Cancer...Cancer Prevention by Tea Polyphenols Is Linked to Their Direct Inhibition of Antiapoptotic Bcl-2-Family Proteins | Cancer...
We performed NMR binding experiments and docking studies with these polyphenols. In bidimensional heteronuclear NMR titration experiments (13) with 15N-labeled Bcl-xL, theaflavin, theaflavanin, and theaflavin-3′ gallate caused a wide broadening of the resonances (Fig. 3A) ⇓ . This result is typical of tight binding, although a high compound to protein ratio was needed, probably due to the limited solubility of the compounds at concentrations needed for NMR (500 μm). The observed broadening of the protein [15N,1H] resonances is characteristic of binding with intermediate exchange rates in the NMR time scale, representative of low- to submicromolar binders. Mapping of the observed changes in the NMR heteronuclear correlation spectra on titration with these compounds into the three-dimensional structure of Bcl-xL showed that many residues within and surrounding the BH3-binding pocket were affected by the compound binding, although the changes extended to a larger region surrounding this ...
Structure-activity relationships in the hydrophobic interactions of polyphenols with cellulose and collagen - NECTARStructure-activity relationships in the hydrophobic interactions of polyphenols with cellulose and collagen - NECTAR
Polyphenol interactions with both cellulose and collagen in the solid state have been studied by using chromatography on cellulose and by evaluating the hydrothermal stability of the polyphenol treated sheepskin collagen. Twenty-four polyphenolic compounds were studied, including seven glucose-based gallotannins, five polyalcohol-based gallotannins, and twelve ellagitannins. In the cellulose-polyphenols systems, the polyphenols affinity to cellulose is positively correlated with their molecular masses, the number of galloyl groups, and their hydrophobicity (logP). The polyphenol treatment increased the hydrothermal stability of collagen samples, and such effects are also positively correlated with the molecular masses, total number of galloyl groups and the hydrophobicity of polyphenols. Ellagitannins showed much weaker interactions with both biopolymers than gallotannins having similar molecular mass, the same number of galloyl groups, and the same number of phenolic hydroxyl groups. It is ...
Plus itPlus it
4287 Prostate cancer (PCa) is the most common invasive malignancy and a major cause of cancer related deaths in male population in the USA. The existing treatment options have not been effective in the management of PCa, and therefore, novel approaches are urgently required. One approach to control this malignancy is through intervention by chemopreventive agents present in diet and beverages humans consume. Our published data in cell culture and animal studies supported by work from other laboratories as well as epidemiological observations and case control studies suggest that polyphenols present in tea plant Camelia sinensis possess PCa chemopreventive and possibly therapeutic effects. This study was designed to compare prostate tumor inhibitory effects of green tea polyphenols (GTP), water extract of black tea (BTE), and their major constituents epigallocatechin-3-gallate (EGCG) and theaflavins (TF), respectively, in athymic nude mice implanted with PCa cells. We chose CWR22Rν1 cells ...
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Studies show that coffee is an exceptional transport mechanism for chlorogenics, which are absorbed into the blood stream and can improve, measured anti-oxidant levels. The trouble though is that many coffees have few chlorogenics or polyphenols.. Researchers are observing how polyphenols can cut the edge off these forces to improve workouts and speed recovery. Add high polyphenols to the caffeine already in coffee itself and you have the ideal training fuel.. I expected perhaps a 10 percent difference. What I found was truly staggering: Coffee beans with as much as 28,193 mg per kilogram of the key chlorogenics in a roasted coffee.. So much so, that they are called the new red wine for the hundreds of discreet flavors from hazelnut to strawberry jam and banana. Dark roasting can destroy up to 80 percent of CQAs, which are the main polyphenols in coffee; and Brew for maximum.. The Science Behind What Makes Coffee Healthy. Hundreds of journal articles3 have linked coffee drinking to decreases in ...
Patente US4555563 - Imide functional polyphenols; thermosettable compositions containing same ... - Google PatentesPatente US4555563 - Imide functional polyphenols; thermosettable compositions containing same ... - Google Patentes
Imide functional polyphenols are prepared by reacting an excess of a phenol with an unsaturated diimide which is prepared by reacting an unsaturated polycycloaliphatic dicarboxylic acid anhydride with a diamine. These materials are useful in the preparation of castings, coatings, laminates and the like.
Pine Bark Extract, Full Spectrum - East West School of Planetary HerbologyPine Bark Extract, Full Spectrum - East West School of Planetary Herbology
Pine bark contains complex polyphenols that are among the most potent of any plant. Pine polyphenols are powerful antioxidants, giving benefits to the cardiovascular system and the immune system. They are well known for supporting capillary health. Polyphenols are vigorous free radical scavengers that help the body reduce oxidative stress.. ...
Search | International Journal of Horticultural ScienceSearch | International Journal of Horticultural Science
Lavandula species are worldwide grown essential oil producing medicinal plants with considerable economic value. Beside volatile oil, lavender also contains different phenolic compounds which have been less widely studied till now. Cultivation of lavender has become widespread in Hungary in the recent years, however, growers have limit...ed knowledge on the productivity of cultivars available. In our research we were aimed to studying the antioxidant capacity and total polyphenol content of samples collected in two growing areas (Dörgicse and Szomód) from flowers of two L. angustifolia (Hidcote, Munstead) and two L. × intermedia (Grosso, Grappenhall) varieties, during the full blooming period of 2017. Antioxidant capacity of the samples was determined by FRAP assay (Benzie and Strain, 1996), while total polyphenol content (TPC) was measured by a modified method of Singleton and Rossi (1965). According to our results, varieties of L. × intermedia showed higher values of antioxidant ...
Does Dealcoholized Wine Have Health Benefits?Does Dealcoholized Wine Have Health Benefits?
Dealcoholized wine retains the antioxidants found in regular wine, but almost no alcohol. Find out if dealcoholized wine is good for your health.
Antioxidants - A Girl With TeaAntioxidants - A Girl With Tea
The Bottle: The researchers found evidence, that half of the bottled teas they sampled had extremely low levels of antioxidants or polyphenols. So low in fact, that they stated one would need to drink 20 bottles of the stuff to achieve the same health benefit as a single cup of home brewed tea.. But, hang on. Theres more.. I do want to point out that the researchers only sampled six bottles of tea. That means that three of those bottles had small amounts of polyphenols, or little to no health benefit. The other three had a healthy amount of antioxidants.. Here are the actual results: The six teas analyzed contained 81, 43, 40, 13, 4, and 3 milligrams (mg) of polyphenols per 16-ounce bottle.. The Brew: The average cup of home-brewed green or black tea contains about 50 to 150 mg of polyphenols.. Round One Results: As you can see from these results, more research is needed in order to firmly state that bottled teas contain little to no antioxidants. In fact, some bottled teas may well be just as ...
پلی‌فنل - ویکی‌پدیا، دانشنامهٔ آزادپلی‌فنل - ویکی‌پدیا، دانشنامهٔ آزاد
True polyphenols from the tannin and other WBSSH types are routinely biosynthesized in the natural sources from which they derive; their chemical syntheses (using standard "bench" organic chemical methods) were somewhat limited until the first decade of the new millennium because these syntheses involve challenging regioselectivity and stereoselectivity issues.[11] Early work focused on the achiral synthesis of phenolic-related components of polyphenols in the late 70s,[12] and the Nelson and Meyers synthesis of the permethyled derivative of the ubiquitous diphenic acid core of ellagitannins in 1994[13] followed by stereoselective synthesis of more complex permethylated structures such as a (+)-tellimagrandin II derivative by Lipshutz and coworkers in the same year,[14] and Itoh and coworkers synthesis of a permethylated pedunculagin with particular attention to axial symmetry issues in 1996.[15] The total synthesis of a fully unmasked polyphenol, that of the ellagitannin tellimagrandin I, ...
Tea diet really can make you slim? | iondevie.bizTea diet really can make you slim? | iondevie.biz
The World Health Organization has done a survey of the strengths and weaknesses of many kinds of drinks in a lot of country and has confirmed that tea is the best drink. According to contained tea polyphenols, caffeine and LPS which are nearly 300 kinds of components. It can regulate the physiological functions of the human body and play an important role for maintaining healthy and pharmacological effects.. Tea diet can prevent the increase of sterol within a human body and is a treatment of myocardial infarction. Tea polyphenols can also clear the excess free radicals within the body and to inhibit and kill pathogens. Moreover, tea is refreshing, can reduce fatigue and has antibacterial effect, etc. Tea can help uplifting ones energy and improve thinking and memory at the same time. It can eliminate fatigue and increase metabolism. It also helps maintaining the heart, blood vessels and gastrointestinal function as such normal function within the human body. It has a great help for the ...
MRSA Bacteria Resistance And Green Tea Antibacterial ResearchMRSA Bacteria Resistance And Green Tea Antibacterial Research
Research on MRSA bacteria (superbugs) has shown that green tea polyphenols can improve the antibiotic oxycillin effectiveness by 8 to 128-fold.
China High Quality 5% Resveratrol, 25% Polyphenols Grape Skin Extract Photos & Pictures - Made-in-china.comChina High Quality 5% Resveratrol, 25% Polyphenols Grape Skin Extract Photos & Pictures - Made-in-china.com
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Slick Extra Virgin » 2010 » FebruarySlick Extra Virgin » 2010 » February
So despite what appeared to be reported in the summary, storing oils in the fridge was the best option of all those studied.. Ok some would be thinking… so it appears that storing the oil at room temperature is just as good as stroring in the fridge so Ill just leave it in my pantry. Well maybe, but then again maybe not. The polyphenol level of the oil used in the study was a massive 772 mg/kg. This is around 3 times the average polyphenol level of your typical EVOO (Gawel and Rogers 2009). Polyphenols are antioxidants, so in this particular case, the polyphenols are providing a massive amount of protection against oxidation. That particular oil probably could have withstood a nuclear test blast in the Nevada desert in 1952 and still be edible today. Whether an EVOO with a more typical polyphenol level of around 200-250mg/kg would have stood up that well at room temperature is debatable. Thats the risk of doing research using a single oil-particularly an odd one!. The abstract also reported ...
Red wine and resveratrol: Good for your heart? - Mayo ClinicRed wine and resveratrol: Good for your heart? - Mayo Clinic
Red wine, in moderation, has long been thought of as heart healthy. The alcohol and certain substances in red wine called antioxidants may help prevent coronary artery disease, the condition that leads to heart attacks.. Any links between red wine and fewer heart attacks arent completely understood. But part of the benefit might be that antioxidants in red wine may increase levels of high-density lipoprotein (HDL) cholesterol (the "good" cholesterol) and protect against cholesterol buildup.. Doctors dont recommend that you start drinking alcohol for heart benefits, especially if you have a family history of alcohol addiction. Too much alcohol can have many harmful effects on your body.. But if you already enjoy a glass of red wine with your evening meal, drinking it in moderation appears to help your heart.. Antioxidants in red wine called polyphenols may help protect the lining of blood vessels in your heart. A polyphenol called resveratrol is one substance in red wine thats gotten attention ...
Sorghum and millets in human nutritionSorghum and millets in human nutrition
Widely distributed polyphenols in plants are not directly involved in any metabolic process and are therefore considered secondary metabolites. Some polyphenolic compounds have a role as defence chemicals, protecting the plant from predatory attacks of herbivores, pathogenic fungi and parasitic weeds. Polyphenols in the grains also prevent grain losses from premature germination and damage due to mould (Harris and Burns, 1970, 1973). Dreyer, Reese and Jones ( 1981) observed that polyphenols protect seedlings from insect attack.. Phenolic compounds in sorghum can be classified as phenolic acids, flavonoids and condensed polymeric phenols known as tannins. Phenolic acids, free or bound as esters, are concentrated in the outer layers of the grain. They inhibit growth of microorganisms and probably impart resistance against grain mould.. Flavonoids in sorghum, derivatives of the monomeric polyphenol flavan-4-ol, are called anthocyanidins. The two flavonoids identified to be abundant in sorghum ...
Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemiaDietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids | 9780128022153 | VitalSourceNatural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids | 9780128022153 | VitalSource
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The inhibitory effect of cacao liquor crude polyphenols (CLP) on experimental arteriosclerosis with calcification in rat soft...The inhibitory effect of cacao liquor crude polyphenols (CLP) on experimental arteriosclerosis with calcification in rat soft...
TY - JOUR. T1 - The inhibitory effect of cacao liquor crude polyphenols (CLP) on experimental arteriosclerosis with calcification in rat soft tissue.. AU - M., Horiuchi. AU - N, Osakabe. AU - T., Takizawa. AU - Y., Seyama. AU - Osakabe, Naomi. PY - 2001/3/1. Y1 - 2001/3/1. M3 - Article. VL - 47. SP - 208. EP - 212. JO - J. Health Sci.. JF - J. Health Sci.. ER - ...
Green tea could reduce lung cancer risk for smokers and non-smokers | EmaxHealthGreen tea could reduce lung cancer risk for smokers and non-smokers | EmaxHealth
Lung cancer is the leading cause of all cancer deaths in Taiwan," said I-Hsin Lin, M.S., a student at Chung Shan Medical University in Taiwan. "Tea, particularly green tea, has received a great deal of attention because tea polyphenols are strong antioxidants, and tea preparations have shown inhibitory activity against tumorigenesis." Past studies that have been poorly controlled have failed to prove that green tea reduces cancer risk, leading scientists to inconclusive evidence about whether green tea really does reduce cancer risk.. The scientists studied 340 healthy individuals and 170 people with lung cancer. Questionnaires were used to determine smoking status, dietary intake of fruits and vegetables, green tea consumption, cooking habits, and family history of lung cancer. The influence of drinking green tea and reduced risk of lung cancer was found by genotyping of insulin like growth factors IGF1, IGF2 and IGFBP3 that are associated with the development of lung cancer. Among the study ...
Sunflower oilSunflower oil
AzaleinAzalein
Edwin HaslamEdwin Haslam
TanninTannin
Quercetin-3,3-bissulfate 7-sulfotransferaseQuercetin-3,3'-bissulfate 7-sulfotransferase
Primulin (anthocyanin)Primulin (anthocyanin)
AzaleatinAzaleatin
TeaTea
Oxygen radical absorbance capacityOxygen radical absorbance capacity
PhenolsPhenols
NutrientNutrient
Treculia africanaTreculia africana
PhlorotanninPhlorotannin
Olive oil extractionOlive oil extraction
Rubus idaeusRubus idaeus
List of antioxidants in foodList of antioxidants in food
Unfiltered olive oilUnfiltered olive oil
Iris setosaIris setosa
Gambier (extract)Gambier (extract)
CaffeineCaffeine
Joseph H. HulseJoseph H. Hulse
FlavonoidFlavonoid
Aprutino PescareseAprutino Pescarese
AroniaAronia
CatechinCatechin
PhlobaphenePhlobaphene
Fuscospora fuscaFuscospora fusca
Plant secondary metabolismPlant secondary metabolism
Vitis rotundifoliaVitis rotundifolia
OreganoOregano
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PolyphenolsPhenolsFlavonoidsTeaCatechinWineBiflavonoidsCamellia sinensisPlant ExtractsPolymersProanthocyanidinsGallic AcidAntioxidantsQuercetinVitisHydrolyzable TanninsTanninsChlorogenic AcidAnticarcinogenic AgentsStilbenesAnthocyaninsCacaoMalusGrape Seed ExtractBiological AvailabilityPhytotherapyBeveragesFruitEllagic AcidRutinPhotiniaPyrogallolFood AnalysisPunicaceaeCurcuminVaccinium macrocarponFlavonolsCaffeic AcidsDietHibiscusBlueberry PlantCrataegusAustriaArthropodsSoilDiet, MediterraneanNutsPlanariansCopyrightWritingLycopersicon esculentumParental ConsentAuthorship
Polyphenols - Universität InnsbruckPolyphenols - Universität Innsbruck
Polyphenols may slash heart disease riskPolyphenols may slash heart disease risk
Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular DiseasesTea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases
Polyphenols and Insulin Resistance - Full Text View - ClinicalTrials.govPolyphenols and Insulin Resistance - Full Text View - ClinicalTrials.gov
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AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth CareGeographicals
PolyphenolsPhenolsFlavonoidsTeaCatechinWineBiflavonoidsCamellia sinensisPlant ExtractsPolymersProanthocyanidinsGallic AcidAntioxidantsQuercetinVitisHydrolyzable TanninsTanninsChlorogenic AcidAnticarcinogenic AgentsStilbenesAnthocyaninsCacaoMalusGrape Seed ExtractBiological AvailabilityPhytotherapyBeveragesFruitEllagic AcidRutinPhotiniaPyrogallolFood AnalysisPunicaceaeCurcuminVaccinium macrocarponFlavonolsCaffeic AcidsDietHibiscusBlueberry PlantCrataegusAustriaArthropodsSoilDiet, MediterraneanNutsPlanariansCopyrightWritingLycopersicon esculentumParental ConsentAuthorship
DietaryFlavonoidsAntioxidantsPlant polyphenolsResveratrolCompoundsEGCGIntakeAbstractCardiovascularMetabolitesConcentration of polyphenolsQuercetinAntioxidant polyphenolsDiet for 8 weeksBioavailabilityOxidative stressFoods Rich In PolyphenolsEffectsConsumptionAcidsContentBlack tea polyphenolsSupplementationFruitsBerriesOxidaseAbundantEndothelialApple polyphenolOlive PolyphenolsTotal polyphenolsDiseasesRatsExtractableNutraceuticalsIntakes
Dietary11
Flavonoids2
  • They argued that this may be due to a reliance on the USDA (US Department of Agriculture) Flavonoid Database, "which captures only a subgroup of polyphenols (the flavonoids) and therefore do not reflect the wide amount and diversity of polyphenols found in food", ​they said. (nutraingredients-usa.com)
  • Polyphenols are classified into two major groups, flavonoids and phenolic compounds . (caasn.com)
Antioxidants3
  • Such strategies include (a) identifying hallmarks of oxidative damage, such as depletion of intracellular glutathione and lipid peroxidation, (b) classical manipulations, such as polyphenol exposures in the absence and presence of antioxidant enzymes (i.e., catalase and superoxide dismutase) and of antioxidants (e.g., glutathione and N-acetylcysteine) and cotreatments with glutathione depleters, and (c) more recent manipulations, such as divalent cobalt and pyruvate to scavenge ROS. (omicsonline.org)
  • Tea polyphenols, generally found in green tea, oolong tea, and black tea, act as antioxidants and help in the prevention of neurodegenerative diseases such as Alzheimer's, Parkinson's. (grandviewresearch.com)
  • Moreover, polyphenols have been widely recognised as powerful antioxidants. (uhi.ac.uk)
Plant polyphenols1
  • The objective of this con ference was to bring together people with a common interest in plant polyphenols and to promote interdisciplinary interactions that will lead to a bet ter understand ing of the importance of these substances. (saintlukebc.org)
Resveratrol1
  • In HepG2 hepatocytes, polyphenols, including resveratrol (a major polyphenol in red wine), apigenin, and S17834 (a synthetic polyphenol), increased phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase (ACC), and they increased activity of AMPK with 200 times the potency of metformin. (diabetesjournals.org)
Compounds3
  • An article appearing online in advance of the publication of the September, 2009 issue of the Journal of Alzheimer's Disease revealed that regular intake of grape seed polyphenols effectively elevates plasma and brain levels of the compounds. (lifeextension.com)
  • Moreover, a food supplement with a combination of four polyphenol-rich compounds showed significant reduction in PSA growth on treatment vs placebo in the PSA-recurrent population (n = 78) as well as in patients being managed with active surveillance prior to local treatment (n = 121). (ascopost.com)
  • Polyphenols are organic compounds found in fruits and vegetables. (selfhacked.com)
EGCG2
Intake3
Abstract1
Cardiovascular5
  • Increased intakes of polyphenols may reduce the risk of cardiovascular disease by an impressive 46%, according to the results of the international PREDIMED (Prevencion con Dieta Mediterranea) study. (nutraingredients-usa.com)
  • For their new study, the researchers used the Phenol-Explorer ​ database to evaluate the polyphenol intakes of 7,172 participants of the study, and the potential associations with cardiovascular events, including heart attack, stroke or death from cardiovascular causes. (nutraingredients-usa.com)
  • The laboratory investigations discussed above do shed light on why large epidemiological studies show that people who consume polyphenols in the highest quantities are protected against conditions such as cancer, cardiovascular disease, and other conditions that are generated by oxidant stress and inflammation. (lifeextension.com)
  • Conclusions This study has shown that increasing the polyphenol content of the diet via consumption of F&V, berries and dark chocolate results in a significant improvement in an established marker of cardiovascular risk in hypertensive participants. (bmj.com)
  • Tea polyphenols enhance the performance of vitamins and hence are used in the treatment of cardiovascular diseases, cancer, etc. (grandviewresearch.com)
Metabolites3
Concentration of polyphenols1
Quercetin1
  • However, the rise in blood uric acid rather than in its polyphenols such as quercetin was associated with this effect [ 2 ]. (selfhacked.com)
Antioxidant polyphenols1
Diet for 8 weeks1
Bioavailability1
  • Polyphenols are characterised by poor absorption, rapid degradation and extensive metabolism, culminating in poor bioavailability (~1 µM). (uhi.ac.uk)
Oxidative stress3
Foods Rich In Polyphenols1
Effects12
  • Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects. (hindawi.com)
  • The demonstration of the beneficial effects of polyphenols will be sensitized by high-fructose feeding for the last 6 days of the protocol. (clinicaltrials.gov)
  • Polyphenols are believed to protect against the formation of beta-amyloid, a toxic protein that forms in the brains of Alzheimer's disease patients which may be responsible for some the disease's damaging effects. (lifeextension.com)
  • Researchers from the National Institute of Advanced Industrial Science and Technology (AIST), have discovered that wheat polyphenols have effects that improve the rhythm of activity and suppress obesity and glucose intolerance in model mice of diet-induced obesity, in collaboration with Nisshin Seifun Group Inc. (medicalxpress.com)
  • 1 As with the previous experiment with apple polyphenols, activation of sirtuins' calorie restriction-mimicking effects was evident. (lifeextension.com)
  • The antioxidant and anti-inflammatory effects of apple polyphenols improved joint mobility and antioxidant status while reducing inflammation in a small trial on 12 healthy people given dry apple peel powder (4.25 g/day for 12 weeks) [ 3 ]. (selfhacked.com)
  • Taken together, 4 small clinical trials (one of them with negative results) cannot be considered sufficient evidence that apple polyphenols have noticeable antioxidant and anti-inflammatory effects in humans. (selfhacked.com)
  • And, there are some studies that show that polyphenols may even reverse the effects of aging. (blgr.info)
  • Here we report the effects of green tea polyphenols on GDH and insulin secretion. (utmb.edu)
  • The effects on gene expression of a diet enriched in polyunsaturated fatty acids (PUFA) and polyphenols vs. a control diet were compared. (unimore.it)
  • Polyphenols are regarded to have a wide range of health-promoting effects. (uhi.ac.uk)
  • Increased consumption of polyphenol-rich food is known to be associated with numerous cardioprotective effects. (uhi.ac.uk)
Consumption2
  • The consumption of whole-wheat flour, which contains polyphenols, is expected to possibly prevent metabolic disorders such as diabetes, obesity, and the metabolic syndrome. (medicalxpress.com)
  • Glucose tolerance tests to investigate the effect of wheat polyphenols on glucose metabolic function in mice showed that the decline in glucose tolerance that occurred over 10 weeks due to a high-fat, high-sucrose diet had been suppressed by the simultaneous consumption of wheat polyphenols (Fig. 2). (medicalxpress.com)
Acids1
  • Developed with olive oil polyphenols, rich in omega-3 and omega-6 fatty acids, and known to calm redness, irritation and inflammation, this lightweight, hypoallergenic, feel-good formula is ideal for even the most sensitive skin types. (neimanmarcus.com)
Content5
Black tea polyphenols2
Supplementation3
  • 9 weeks of supplementation with polyphenols(D56) and during the last week supplementation with polyphenols associated with a fructose load during the last 6 days (D63). (clinicaltrials.gov)
  • Until 2015, physicians and patients discussing pomegranate and other forms of polyphenol supplementation relied primarily on a 2006 study by Pantuck and his colleagues, which reported treatment with 8 oz of pomegranate juice daily, until disease progression, resulted in lengthening of the mean PSA doubling time from 15 to 54 months in prostate cancer patients who were experiencing PSA recurrence following prostatectomy and/or radiation. (ascopost.com)
  • Partial results show that the diet supplementation with PUFA and polyphenols influences the transcription of genes involved in the long chain FA synthesis and in lipids utilization. (unimore.it)
Fruits1
  • Polyphenols are a diverse group of phytonutrients that determine colours of the fruits and vegetables, and protect the plants from diseases and invasion of external microorganisms. (caasn.com)
Berries1
  • Observational evidence to date indicates that polyphenol-rich foods, in particular berries 3 , 4 and dark chocolate, 5-7 may influence CVD risk. (bmj.com)
Oxidase1
  • In a clinical trial on 62 overweight people, apple polyphenol extract reduced oxidative damage to the blood vessels In test tubes, they inhibited an enzyme that produces free radicals (xanthine oxidase) [ 1 ]. (selfhacked.com)
Abundant1
  • In the proposed study we want to analyse the polyphenol contents of fresh plant material and litter of different stages (overwintered litter and one-year old litter) of plant species abundant on alpine areas. (uibk.ac.at)
Endothelial2
  • The green tea polyphenols contributed to minimizing tumor development by governing the amount of vascular endothelial growth factor (VEGF) in the serum of the prostate cancer mouse model. (eurekalert.org)
  • Polyphenols have been shown to improve endothelial function, inhibit abnormal platelet aggregation, reduce inflammation and improve plasma lipid profiles. (uhi.ac.uk)
Apple polyphenol2
  • 2 When scientists added the unique apple polyphenol phloridzin to yeast cells in culture, they found that treated cultures lived an average of 2.3 generations longer than control cultures. (lifeextension.com)
  • In another trial on 62 overweight people, apple polyphenol extract reduced fasting blood sugar [ 1 ]. (selfhacked.com)
Olive Polyphenols1
  • Skin Soothing Mineral Sunscreen with Olive Polyphenols SPF 40, 2.4 oz. (neimanmarcus.com)
Total polyphenols1
  • Functional beverages were followed by functional food which accounted for over 30% of the total polyphenols consumed globally in 2012. (grandviewresearch.com)
Diseases2
Rats3
Extractable2
Nutraceuticals3
Intakes1
  • Crunching the numbers revealed that the highest overall intakes of polyphenols (an average of 1,170 milligrams per day) were associated with a 46% reduction in the risk of CVD, compared to the lowest overall intakes (an average of 562 mg per day). (nutraingredients-usa.com)
Polyphenols and Insulin Resistance - Full Text View - ClinicalTrials.gov
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Molecules | Free Full-Text | Grape Polyphenols' Effects in Human Cardiovascular Diseases and Diabetes | HTML
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Apple Peel Polyphenols and Their Beneficial Actions on Oxidative Stress and Inflammation
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Estrogen Receptor Alpha as a Key Target of Red Wine Polyphenols Action on the Endothelium
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