Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
Synthetic thermoplastics that are tough, flexible, inert, and resistant to chemicals and electrical current. They are often used as biocompatible materials for prostheses and implants.
A vinyl polymer made from ethylene. It can be branched or linear. Branched or low-density polyethylene is tough and pliable but not to the same degree as linear polyethylene. Linear or high-density polyethylene has a greater hardness and tensile strength. Polyethylene is used in a variety of products, including implants and prostheses.
A generic grouping for dihydric alcohols with the hydroxy groups (-OH) located on different carbon atoms. They are viscous liquids with high boiling points for their molecular weights.
An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.
Agents that are used to stimulate evacuation of the bowels.
A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
A diphenylmethane stimulant laxative used for the treatment of CONSTIPATION and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871)
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The formation of a solid in a solution as a result of a chemical reaction or the aggregation of soluble substances into complexes large enough to fall out of solution.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
Relating to the size of solids.
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Characteristics or attributes of the outer boundaries of objects, including molecules.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Replacement for a hip joint.
Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.
A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887)
Polyester polymers formed from terephthalic acid or its esters and ethylene glycol. They can be formed into tapes, films or pulled into fibers that are pressed into meshes or woven into fabrics.
Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.
The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis.
Agents that produce a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve CONSTIPATION.
Derivatives of propylene glycol (1,2-propanediol). They are used as humectants and solvents in pharmaceutical preparations.
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
Endoscopic examination, therapy or surgery of the luminal surface of the colon.
Chemical compounds derived from acids by the elimination of a molecule of water.
The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)
The plan and delineation of prostheses in general or a specific prosthesis.
Magnesium oxide (MgO). An inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses.
The protoplasm and plasma membrane of plant, fungal, bacterial or archaeon cells without the CELL WALL.
A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.
The sum of the weight of all the atoms in a molecule.
The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.
Dissolution of bone that particularly involves the removal or loss of calcium.
A polyester used for absorbable sutures & surgical mesh, especially in ophthalmic surgery. 2-Hydroxy-propanoic acid polymer with polymerized hydroxyacetic acid, which forms 3,6-dimethyl-1,4-dioxane-dione polymer with 1,4-dioxane-2,5-dione copolymer of molecular weight about 80,000 daltons.
Chemical analysis based on the phenomenon whereby light, passing through a medium with dispersed particles of a different refractive index from that of the medium, is attenuated in intensity by scattering. In turbidimetry, the intensity of light transmitted through the medium, the unscattered light, is measured. In nephelometry, the intensity of the scattered light is measured, usually, but not necessarily, at right angles to the incident light beam.
The chemical and physical integrity of a pharmaceutical product.
Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
A network of cross-linked hydrophilic macromolecules used in biomedical applications.
Formation of a firm impassable mass of stool in the RECTUM or distal COLON.
Strongly cationic polymer that binds to certain proteins; used as a marker in immunology, to precipitate and purify enzymes and lipids. Synonyms: aziridine polymer; Epamine; Epomine; ethylenimine polymer; Montrek; PEI; Polymin(e).
A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)
Specific alloys not less than 85% chromium and nickel or cobalt, with traces of either nickel or cobalt, molybdenum, and other substances. They are used in partial dentures, orthopedic implants, etc.
Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.
Enzymes that activate one or more COMPLEMENT PROTEINS in the complement system leading to the formation of the COMPLEMENT MEMBRANE ATTACK COMPLEX, an important response in host defense. They are enzymes in the various COMPLEMENT ACTIVATION pathways.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Nanometer-sized, hollow, spherically-shaped objects that can be utilized to encapsulate small amounts of pharmaceuticals, enzymes, or other catalysts (Glossary of Biotechnology and Nanobiotechnology, 4th ed).
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)
Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.
The rate dynamics in chemical or physical systems.
Tendency of fluids (e.g., water) to move from the less concentrated to the more concentrated side of a semipermeable membrane.
The pressure required to prevent the passage of solvent through a semipermeable membrane that separates a pure solvent from a solution of the solvent and solute or that separates different concentrations of a solution. It is proportional to the osmolality of the solution.
Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.
Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.
The branch of medicine concerned with the application of NANOTECHNOLOGY to the prevention and treatment of disease. It involves the monitoring, repair, construction, and control of human biological systems at the molecular level, using engineered nanodevices and NANOSTRUCTURES. (From Freitas Jr., Nanomedicine, vol 1, 1999).
A carrier or inert medium used as a solvent (or diluent) in which the medicinally active agent is formulated and or administered. (Dictionary of Pharmacy, 1986)
Substances that provide protection against the harmful effects of freezing temperatures.
Tree-like, highly branched, polymeric compounds. They grow three-dimensionally by the addition of shells of branched molecules to a central core. The overall globular shape and presence of cavities gives potential as drug carriers and CONTRAST AGENTS.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.
A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice for central nervous system depression.
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids.
Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.
A ubiquitous sodium salt that is commonly used to season food.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.
Substances used to cause adherence of tissue to tissue or tissue to non-tissue surfaces, as for prostheses.
The part of the pelvis that comprises the pelvic socket where the head of FEMUR joins to form HIP JOINT (acetabulofemoral joint).
A cellulose of varied carboxyl content retaining the fibrous structure. It is commonly used as a local hemostatic and as a matrix for normal blood coagulation.
A series of steps taken in order to conduct research.
Elements of limited time intervals, contributing to particular results or situations.
The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Replacement of the hip joint.
Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.
A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
An oxide of aluminum, occurring in nature as various minerals such as bauxite, corundum, etc. It is used as an adsorbent, desiccating agent, and catalyst, and in the manufacture of dental cements and refractories.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Substances that are used in place of blood, for example, as an alternative to BLOOD TRANSFUSIONS after blood loss to restore BLOOD VOLUME and oxygen-carrying capacity to the blood circulation, or to perfuse isolated organs.
Uptake of substances through the lining of the INTESTINES.
A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Preparations of Cassia senna and C. angustifolia (see SENNA PLANT). They contain sennosides, which are anthraquinone type CATHARTICS and are used in many different preparations as laxatives.
Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
An abnormally low volume of blood circulating through the body. It may result in hypovolemic shock (see SHOCK).
A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.
A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794)
A group of compounds that are monomethyl derivatives of pyridines. (From Dorland, 28th ed)
A subclass of IMIDES with the general structure of pyrrolidinedione. They are prepared by the distillation of ammonium succinate. They are sweet-tasting compounds that are used as chemical intermediates and plant growth stimulants.
The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
A poly(dimethylsiloxane) which is a polymer of 200-350 units of dimethylsiloxane, along with added silica gel. It is used as an antiflatulent, surfactant, and ointment base.
A peptide which is a homopolymer of lysine.
Spherical particles of nanometer dimensions.
Catalyze the joining of preformed ribonucleotides or deoxyribonucleotides in phosphodiester linkage during genetic processes. EC 6.5.1.
The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.
Replacement for a knee joint.
Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.
Inorganic salts of phosphoric acid.
A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.
Passage of food (sometimes in the form of a test meal) through the gastrointestinal tract as measured in minutes or hours. The rate of passage through the intestine is an indicator of small bowel function.
Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.
Proteins prepared by recombinant DNA technology.
A plant genus of the family FABACEAE.
Hard or soft soluble containers used for the oral administration of medicine.
The hemispheric articular surface at the upper extremity of the thigh bone. (Stedman, 26th ed)
Uptake of substances through the SKIN.
A biocompatible polymer used as a surgical suture material.
Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.
The thermodynamic interaction between a substance and WATER.
Zirconium. A rather rare metallic element, atomic number 40, atomic weight 91.22, symbol Zr. (From Dorland, 28th ed)
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Rounded objects made of coral, teflon, or alloplastic polymer and covered with sclera, and which are implanted in the orbit following enucleation. An artificial eye (EYE, ARTIFICIAL) is usually attached to the anterior of the orbital implant for cosmetic purposes.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
Biological activities and function of the whole organism in human, animal, microorgansims, and plants, and of the biosphere.
Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.
Chemical reaction in which monomeric components are combined to form POLYMERS (e.g., POLYMETHYLMETHACRYLATE).
Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.
A method of separation of two or more substances by repeated distribution between two immiscible liquid phases that move past each other in opposite directions. It is a form of liquid-liquid chromatography. (Stedman, 25th ed)
Liquids transforming into solids by the removal of heat.
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
Materials incorporated mechanically in plastics (usually PVC) to increase flexibility, workability or distensibility; due to the non-chemical inclusion, plasticizers leach out from the plastic and are found in body fluids and the general environment.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
Regulatory genes which encode a cyclic AMP receptor protein required for L-arabinose utilization in E. coli. It is an example of positive control or regulation of gene expression in the bacterial operon.
Process of using a rotating machine to generate centrifugal force to separate substances of different densities, remove moisture, or simulate gravitational effects. It employs a large motor-driven apparatus with a long arm, at the end of which human and animal subjects, biological specimens, or equipment can be revolved and rotated at various speeds to study gravitational effects. (From Websters, 10th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
The joint that is formed by the articulation of the head of FEMUR and the ACETABULUM of the PELVIS.
A cell line derived from cultured tumor cells.
Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.
Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used for dehydrating pharmaceutical and food products.
Established cell cultures that have the potential to propagate indefinitely.
A solution or compound that is introduced into the RECTUM with the purpose of cleansing the COLON or for diagnostic procedures.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
A family of marine mollusks in the class BIVALVIA, commonly known as oysters. They have a rough irregular shell closed by a single adductor muscle.
Injections made into a vein for therapeutic or experimental purposes.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
SURFACE-ACTIVE AGENTS that induce a dispersion of undissolved material throughout a liquid.
A genus of PICORNAVIRIDAE causing infectious hepatitis naturally in humans and experimentally in other primates. It is transmitted through fecal contamination of food or water. HEPATITIS A VIRUS is the type species.
4-carbon straight chain aliphatic hydrocarbons substituted with two hydroxyl groups. The hydroxyl groups cannot be on the same carbon atom.
An inorganic compound that occurs in nature as the mineral brucite. It acts as an antacid with cathartic effects.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
Poly-2-methylpropenoic acids. Used in the manufacture of methacrylate resins and plastics in the form of pellets and granules, as absorbent for biological materials and as filters; also as biological membranes and as hydrogens. Synonyms: methylacrylate polymer; poly(methylacrylate); acrylic acid methyl ester polymer.
An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.
Products made by baking or firing nonmetallic minerals (clay and similar materials). In making dental restorations or parts of restorations the material is fused porcelain. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Boucher's Clinical Dental Terminology, 4th ed)
A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Sulfuric acid diammonium salt. It is used in CHEMICAL FRACTIONATION of proteins.

Stabilization of poly-L-lysine/DNA polyplexes for in vivo gene delivery to the liver. (1/6763)

We are developing a self-assembling non-viral in vivo gene delivery vehicle based on poly-l-lysine and plasmid DNA. We have characterized poly-l-lysines of different chain lengths for DNA condensation and strength of DNA binding. Poly-l-lysine chains >20 residues bound DNA efficiently in physiological saline, while shorter chains did not. Attachment of asialoorosomucoid to PLL increased the PLL chain length required for efficient DNA binding in saline and for efficient DNA condensation. By electron microscopy, poly-l-lysine/DNA polyplexes appeared as toroids 25-50 nm in diameter or rods 40-80 nm long; conjugation of asialoorosomucoid to the polylysine component increased the size of resulting polyplexes to 50-90 nm. In water, poly-l-lysine and asialoorosomucoid-PLL polyplexes have effective diameters of 46 and 87.6 nm, respectively. Polyplexes containing only poly-l-lysine and DNA aggregated in physiological saline at all charge ratios and aggregated at neutral charge ratios in water. Attachment of asialoorosomucoid lessened, but did not eliminate, the aggregation of PLL polyplexes, and did not result in efficient delivery of polyplexes to hepatocytes. Conjugation of polyethylene glycol to poly-l-lysine sterically stabilized resulting polyplexes at neutral charge ratios by shielding the surfaces. For efficient in vivo gene delivery, polyplexes will need to be sterically stabilized to prevent aggregation and interaction with serum components.  (+info)

Partial purification and properties of porcine thymus lactosylceramide beta-galactosidase. (2/6763)

Porcine thymus lactosylceramide beta-galactosidase was purified by a simple procedure. In the final step of isoelectric focusing the enzyme was separated into two peaks of pI 6.3 (peak I) and 7.0 (peak II), which showed 3,600- and 4,000-fold enhancement of lactosylceramide-hydrolysing activity, respectively. The two peaks had identical mobility on polyacrylamide gel electrophoresis. The apparent molecular weight was 34,000. Neither monosialoganglioside (GM1) nor galactosylceramide was hydrolysed by the purified enzyme fractions. The optimal pH was at 4.6, and sodium taurocholate was essential for the reaction. The apparent Km was 2.3 x 10-5 M. The reaction was stimulated by sodium chloride and linoleic acid, while it was strongly inhibited by Triton X-100 and bovine serum albumin. Galactosylceramide, p-nitrophenyl beta-galactoside, and p-nitrophenol were weak inhibitors. No effects of GM1 and galactose were observed on the hydrolysis of lactosylceramide.  (+info)

Further studies on the mechanism of adrenaline-induced lipolysis in lipid micelles. (3/6763)

Lipase [EC 3.1.1.3] depleted lipid micelles, in which lipolysis was not elicited by adrenaline, were prepared from lipid micelles. When these lipase-depleted lipid micelles incubated with adipose tissue extract containing lipase activity, adrenaline-induced lipolysis was restored to almost the same level as that of native lipid micelles. Adrenaline-induced lipolysis was not restored when the lipase-depleted lipid micelles were homogenized or sonicated. Various tissue extracts from kidney, lung, liver, and pancreas, and post-heparin plasma, which contained lipase activity, restored adrenaline-induced lipolysis in lipase-depleted lipid micelles.  (+info)

A lipid modified ubiquitin is packaged into particles of several enveloped viruses. (4/6763)

An anti-ubiquitin cross-reactive protein which migrates more slowly (6.5 kDa) by SDS-PAGE than ubiquitin was identified in African swine fever virus particles. This protein was extracted into the detergent phase in Triton X-114 phase separations, showing that it is hydrophobic, and was radiolabelled with both [3H]palmitic acid and [32P]orthophosphate. This indicates that the protein has a similar structure to the membrane associated phosphatidyl ubiquitin described in baculovirus particles. A similar molecule was found in vaccinia virus and herpes simplex virus particles, suggesting that it may be a component of uninfected cell membranes, which is incorporated into membrane layers in virions during morphogenesis.  (+info)

Structural and functional consequences of antigenic modulation of red blood cells with methoxypoly(ethylene glycol). (5/6763)

We previously showed that the covalent modification of the red blood cell (RBC) surface with methoxypoly(ethylene glycol) [mPEG; MW approximately 5 kD] could significantly attenuate the immunologic recognition of surface antigens. However, to make these antigenically silent RBC a clinically viable option, the mPEG-modified RBC must maintain normal cellular structure and functions. To this end, mPEG-derivatization was found to have no significant detrimental effects on RBC structure or function at concentrations that effectively blocked antigenic recognition of a variety of RBC antigens. Importantly, RBC lysis, morphology, and hemoglobin oxidation state were unaffected by mPEG-modification. Furthermore, as shown by functional studies of Band 3, a major site of modification, PEG-binding does not affect protein function, as evidenced by normal SO4- flux. Similarly, Na+ and K+ homeostasis were unaffected. The functional aspects of the mPEG-modified RBC were also maintained, as evidenced by normal oxygen binding and cellular deformability. Perhaps most importantly, mPEG-derivatized mouse RBC showed normal in vivo survival ( approximately 50 days) with no sensitization after repeated transfusions. These data further support the hypothesis that the covalent attachment of nonimmunogenic materials (eg, mPEG) to intact RBC may have significant application in transfusion medicine, especially for the chronically transfused and/or allosensitized patient.  (+info)

Enhancement of endocytosis due to aminophospholipid transport across the plasma membrane of living cells. (6/6763)

Formation of intracellular vesicles is initiated by membrane budding. Here we test the hypothesis that the plasma membrane surface area asymmetry could be a driving force for vesicle formation during endocytosis. The inner layer phospholipid number was therefore increased by adding exogenous aminophospholipids to living cells, which were then translocated from the outer to the inner layer of the membrane by the ubiquitous flippase. Addition of either phosphatidylserine or phosphatidylethanolamine led to an enhancement of endocytosis, showing that the observed acceleration does not depend on the lipid polar head group. Conversely, a closely related aminophospholipid that is not recognized by the flippase, lyso-alpha-phosphatidylserine, inhibited endocytosis, and similar results were obtained with a cholesterol derivative that also remains in the plasma membrane outer layer. Thus an increase of lipid concentration in the inner layer enhanced internalization, whereas an increase of the lipid concentration in the outer layer inhibited internalization. These experiments suggest that transient asymmetries in lipid concentration might contribute to the formation of endocytic vesicles.  (+info)

The pharmacokinetics of artemisinin after administration of two different suppositories to healthy Vietnamese subjects. (7/6763)

Eight healthy Vietnamese male subjects received 400 mg artemisinin formulated into fatty suppositories (FS), and six different subjects received 500 mg of artemisinin formulated in polyethylene glycol suppositories (PEGS). Plasma concentrations were measured by high-performance liquid chromatography with electrochemical detection; concentration versus time curves were analyzed with nonparametric methods. No statistically significant differences were found between the two formulations. The maximum concentration (Cmax) was 100 +/- 102 microg/L (mean +/- SD, range = 24-330) microg/L (FS), the pharmacokinetic lag time (Tlag) was 1.3 +/- 1.0 hr (range = 0-3) (FS), and the time of the maximum concentration (Tmax) was 7.1 +/- 2.1 hr (range = 3-10) hr (FS). Because artemisinin is not available for intravenous dosage, absolute bioavailability cannot be assessed. However, compared with a previous study on oral artemisinin in healthy Vietnamese subjects, bioavailability relative to oral administration was estimated to be approximately 30%. We conclude that therapeutic blood concentrations of artemisinin can be reached after rectal dosage. The dose after rectal administration should probably be higher than after oral administration; doubling or tripling the oral dose might be necessary, which would imply a rectal dose of at least 20 mg/kg of body weight given twice a day.  (+info)

Opposite behavior of two isozymes when refolding in the presence of non-ionic detergents. (8/6763)

GroEL has a greater affinity for the mitochondrial isozyme (mAAT) of aspartate aminotransferase than for its cytosolic counterpart (cAAT) (Mattingly JR Jr, Iriarte A, Martinez-Carrion M, 1995, J Biol Chem 270:1138-1148), two proteins that share a high degree of sequence similarity and an almost identical spatial structure. The effect of detergents on the refolding of these large, dimeric isozymes parallels this difference in behavior. The presence of non-ionic detergents such as Triton X-100 or lubrol at concentrations above their critical micelle concentration (CMC) interferes with reactivation of mAAT unfolded in guanidinium chloride but increases the yield of cAAT refolding at low temperatures. The inhibitory effect of detergents on the reactivation of mAAT decreases progressively as the addition of detergents is delayed after starting the refolding reaction. The rate of disappearance of the species with affinity for binding detergents coincides with the slowest of the two rate-limiting steps detected in the refolding pathway of mAAT. Limited proteolysis studies indicate that the overall structure of the detergent-bound mAAT resembles that of the protein in a complex with GroEL. The mAAT folding intermediates trapped in the presence of detergents can resume reactivation either upon dilution of the detergent below its CMC or by adding beta-cyclodextrin. Thus, isolation of otherwise transient productive folding intermediates for further characterization is possible through the use of detergents.  (+info)

Export Data And Price Of Methoxypolyethylene Glycol , www.eximpulse.com Eximpulse Services is the place where you can find the recent and updated Trade intelligence report of Methoxypolyethylene Glycol Export Data. Whole information is based on updated Export shipment data of Indian Customs. All the compilation is done on the basis of All India ports data and has been done on daily basis. This helps you to get all India Methoxypolyethylene Glycol Export data. You can find previous two days Methoxypolyethylene Glycol Export data on Eximpulse Services. Methoxypolyethylene Glycol Export data can be useful in different kind of analysis such as: Export price, Quantity, market scenarios, Price trends, Duty optimization and many more. Some Sample Shipment records for Methoxypolyethylene Glycol Export Data of India are mentioned above. Further for Free sample and pricing of detailed reports contact on [email protected] Data post 2012 as per Notification No.18/2012 - Customs(N.T.) and does not have ...
TY - JOUR. T1 - Accelerated blood clearance phenomenon upon repeated injection of peg-modified pla-nanoparticles. AU - Ishihara, Tsutomu. AU - Takeda, Miho. AU - Sakamoto, Haruka. AU - Kimoto, Ayumi. AU - Kobayashi, Chisa. AU - Takasaki, Naoko. AU - Yuki, Kanae. AU - Tanaka, Ken Ichiro. AU - Takenaga, Mitsuko. AU - Igarashi, Rie. AU - Maeda, Taishi. AU - Yamakawa, Naoki. AU - Okamoto, Yoshinari. AU - Otsuka, Masami. AU - Ishida, Tatsuhiro. AU - Kiwada, Hiroshi. AU - Mizushima, Yutaka. AU - Mizushima, Tohru. PY - 2009/10/1. Y1 - 2009/10/1. N2 - Purpose: We recently developed prostaglandin E1 (PGE 1)-encapsulated nanoparticles, prepared with a poly(lactide) homopolymer (PLA, Mw∈=∈17,500) and monomethoxy poly(ethyleneglycol)- PLA block copolymer (PEG-PLA) (NP-L20). In this study, we tested whether the accelerated blood clearance (ABC) phenomenon is observed with NP-L20 and other PEG-modified PLA-nanoparticles in rats. Methods: The plasma levels of PGE 1 and anti-PEG IgM antibody were determined ...
We have explored the concept of using the bacterial enzyme thiaminase to disrupt energy metabolism in cancer. To optimize the biological and pharmacologic properties of this enzyme, we studied the effects of modifying it with the addition of linear polyethylene glycol chains of various sizes, a common technique that can increase plasma retention time and reduce immunogenicity of foreign proteins. Figure 1 demonstrates that the protein was successfully modified by these PEG chains of various lengths. For most of the subsequent studies we focused on the intermediate, 5k-PEG modified thiaminase enzyme in comparison with native enzyme.. We initially hypothesized that thiaminase worked through an extracellular mechanism of action, by catabolizing extracellular thiamine and causing acute thiamine starvation. Indeed, Fig. 2 shows that both native and 5k-PEG thiaminase are very potent in the catabolism of thiamine, achieving a 100-fold reduction of thiamine in medium at concentrations of 0.0001 ...
Pegylated interferon alpha 2b is used in the treatment of chronic hepatitis b virus (hbv) infection,chronic hepatitis c virus (hcv) infection,multiple myeloma(blood cancer),follicular lymphoma,hairy cell leukemia.get complete information about pegylated interferon alpha 2b including usage, side effects, drug interaction, expert advice along with medicines associated with pegylated interferon alpha 2b at 1mg.com
Find everything you need to know about Mircera (Epoetin Beta And Methoxy Polyethylene Glycol), including what it is used for, warnings, reviews, side effects, and interactions. Learn more about Mircera (Epoetin Beta And Methoxy Polyethylene Glycol) at EverydayHealth.com.
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email protected] Recommended for excipient applications, topical creams, lotions, personal care products, and solid oral dose. Polyethylene Glycol 6. Product Information Table of contents 3 4 6 Introduction. Polyethylene Glycol 8000, NF acts as a lubricant, coating the surfaces in aqueous and non-aqueous environments. It is also used to empty the bowels before a colonoscopy. MiraLAX Laxative Powder for Gentle Constipation Relief, #1 Dr. Polyethylene glycol 6,000. polyethylene glycol standard set mp 400-40000 polyethylene glycol, diglycidyl bisphenol a polymer polyethylene glycol/polyethylene oxide standard readycal set mp 500-2740000. chemBlink provides information about CAS # 9005-08-7, Polyethylene glycol distearate, AM 112, AM 113, Atmer 122, Atmer 123, Atmos 150, Atmul 124, Atmul 67, Atmul P. After a short sample clean-up, carbon-oxygen linkages were partially cleaved with 0. National regulations Germany AwSV/VwVwS Annex reference : Water hazard class (WGK) 1, slightly hazardous to water ...
The present invention provides a long circulating non-pegylated liposomal doxorubicin hydrochloride composition for parenteral administration and a process for its preparation. The circulation time in Swiss albino mice is at least 25 times longer than conventional non-liposomal formulations. The non-pegylated liposomes are stable, exhibit low toxicity and have been found to be efficacious in different tumor models.
Source Text: English CARBOWAX Polyethylene Glycols (PEGs) and CARBOWAX Methoxypolyethylene Glycols (MPEGs) are a family of watersoluble linear polymers formed by the addition reaction of ethylene oxide to an ethylene glycol equivalent. The general formula for polyethylene glycol is: H-(OCH2CH2)n-OH and for methoxypolyethylene glycol: CH3-(OCH2CH2)n-OH where n is the average number of repeating oxyethylene groups. […]. Read More. ...
Page contains details about doxorubicin-loaded phospholipid-polyethylene glycol-modified oxidized single-walled nanotubes . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
heparin drug combination ethyleneglycol monosalicylate escin: combination of aescin, heparin & ethyleneglycol monosalicylate used in topical treatment of edema, hematoma
Under the trade name Mircera, Roche Pharmaceuticals received approval from the U.S. Food and Drug Administration (FDA) in January 2008 to market a continuous erythropoiesis receptor activator (methoxy polyethylene glycol-epoetin beta) for the treatment of anemia in patients with chronic kidney disease, including in those undergoing dialysis.[1] (Patent disputes between Amgen, which owns several patents relating to recombinant EPO variants, and Roche are blocking distribution of Mircera in the U.S. This issue appears to have been resolved since Fresenius Medical dialysis clinics in the US are now administering this drug.) Methoxy polyethylene glycol-epoetin beta had been approved by the European Commission in August 2007, and was made available in Europe at the start of 2008.. In terms of its structure, Mircera is similar to the previous synthetic EPO drugs, except that it is connected to a chemical called polyethylene glycol (PEG), which makes it last longer in the body. According to Roche, the ...
Export Data And Price Of Polyethylene Glycol , www.eximpulse.com Eximpulse Services is the place where you can find the recent and updated Trade intelligence report of Polyethylene Glycol Export Data. Whole information is based on updated Export shipment data of Indian Customs. All the compilation is done on the basis of All India ports data and has been done on daily basis. This helps you to get all India Polyethylene Glycol Export data. You can find previous two days Polyethylene Glycol Export data on Eximpulse Services. Polyethylene Glycol Export data can be useful in different kind of analysis such as: Export price, Quantity, market scenarios, Price trends, Duty optimization and many more. Some Sample Shipment records for Polyethylene Glycol Export Data of India are mentioned above. Further for Free sample and pricing of detailed reports contact on [email protected] Data post 2012 as per Notification No.18/2012 - Customs(N.T.) and does not have names of Indian companies and Foreign ...
Table of Contents for Global Methoxy Polyethylene Glycol (MPEG) Market by Manufacturers, Countries, Type and Application, Forecast to 2022 by Global Info Research Available at market-research-reports.com.
Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Weisberger on methoxy polyethylene glycol epoetin beta dosage: It depends on clinical scenario . Metoprolol for instance is twice per day unless is long acting metoprolol succinate. Digoxin is once per day. The rest of drugs varies.
Cardiotoxicity with rituximab, cyclophosphamide, non-pegylated liposomal doxorubicin, vincristine and prednisolone compared to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone in frontline treatment of patients with diffuse large B-cell lymphoma: A randomised phase-III study from the Austrian Cancer Drug Therapy Working Group [Arbeitsgemeinschaft Medikamentöse Tumortherapie AGMT](NHL-14 ...
Press Release issued Dec 8, 2016: Polyethylene glycol (PEG) is one of the most frequently used non-ionic polymers in polymer-based drug delivery and other bioactivities. Since polyethylene glycol has high aqueous solubility, it is considered for pro-drug conjugation. This appreciative status and use of PEGlycation technology in biotechnological and pharmaceutical applications has led to many progressive steps in the medical field. The existent scientific literature testifies for the various applications of polymers derived from polyethylene glycol (PEGs). The collective experience surrounding this material and relief provided by governing authorities around the world regarding its usage will lead to its increased usage in many medical device applications and drugs, which in turn will expand the market for polyethylene glycol in research and development areas. Better opportunities are predicted for the polyethylene glycol market in a range of applications such as diagnostics areas and drug development,
This is an open-label (all the people know the identity of the intervention), single arm (study will be conducted in a single group) clinical study, to evaluate the safety, tolerability and efficacy of TMC435 along with pegylated interferon alpha-2a (PegIFNα-2a) and ribavirin (RBV) triple therapy in adult chronic hepatitis C (CHC) genotype-1 infected patients who are co-infected with human immunodeficiency virus-type 1 (HIV-1). The study consists of 3 phases, screening phase (Week -6), treatment phase, and a follow-up phase (up to 24 weeks). In the treatment phase, patients will be classified based on their experience with previous hepatitis C virus (HCV) treatment as follows: 1) HCV treatment-naive (patients who never received medication for the treatment of HCV); 2) prior HCV relapsers (patients who received at least 24 weeks of a PegIFNα-2a and RBV-based therapy and relapsed within 1 year after the last medication intake); and 3) prior HCV non-responders (can be further classified as, null ...
This is an open-label (all the people know the identity of the intervention), single arm (study will be conducted in a single group) clinical study, to evaluate the safety, tolerability and efficacy of TMC435 along with pegylated interferon alpha-2a (PegIFNα-2a) and ribavirin (RBV) triple therapy in adult chronic hepatitis C (CHC) genotype-1 infected patients who are co-infected with human immunodeficiency virus-type 1 (HIV-1). The study consists of 3 phases, screening phase (Week -6), treatment phase, and a follow-up phase (up to 24 weeks). In the treatment phase, patients will be classified based on their experience with previous hepatitis C virus (HCV) treatment as follows: 1) HCV treatment-naive (patients who never received medication for the treatment of HCV); 2) prior HCV relapsers (patients who received at least 24 weeks of a PegIFNα-2a and RBV-based therapy and relapsed within 1 year after the last medication intake); and 3) prior HCV non-responders (can be further classified as, null ...
POLYETHYLENE GLYCOLS Explanation Includes polyethylene glycol 200, polyethylene glycol 300, polyethylene glycol 400, polyethylene glycol 600, polyethylene glycol 1000, polyethylene glycol 1500, polyethylene glycol 1540, polyethylene glycol 4000, polyethylene glycol 6000, polyethylene glycol 9000, and polyethylene glycol 10 000.
In the interest of creating readily transfusable blood, we have developed a method of covalently bonding methoxy polyethylene gylcol (mPEG) to the erythrocyte membrane to mask antigens which would otherwise cause immunorejection in unmatched blood tr
Sustained Virological Response to Pegylated Interferon Alfa-2b (PegIntron) with or without Ribavirin Predicts Continued Response through 5 Years Sustained virological response (SVR), or continued undetectable HCV viral load 24 weeks after completion of interferon-based therapy, is widely regarded as a cure for chronic hepatitis C.. As reported at the recent Digestive Disease Week 2008 conference in San Diego, Karen Lindsay and an international team of colleagues conducted a study to confirm whether SVR predicts long-term (, 5 years) HCV clearance in adults treated with pegylated interferon, as has already been demonstrated for conventional interferon.. The present analysis included 567 adult chronic hepatitis C patients from 2 previously published clinical trials (Lindsay et al, Hepatology 2001, 34:395-403; Manns et al, Lancet 2001, 358:958-965) who were treated with pegylated interferon alfa-2b (PegIntron) with or without ribavirin.. Participants completed the initial 24 weeks of follow-up and ...
Cooksley et al 2003 is an open-label trial, which assessed the efficacy and safety of different doses of peginterferon alfa-2a vs. interferon alfa-2a 4.5 MIU for 24 weeks of therapy followed by 24 weeks of treatment-free follow up in 194 interferon-naïve patients with chronic hepatitis B. There was a non-significant higher incidence of serious adverse events in the peginterferon alfa-2a 180μg/week group (8.6%) as compared with interferon 4.5 MIU /three times a week group (4%). The most common causes of SAEs were gastrointestinal disorders and infections. There was no difference in virologic or immunologic outcomes (such as loss of DNA or seroconversion) between peginterferon alfa-2a 180μg/wk and interferon alfa-2a 4.5 MIU group. The basis of choosing 180μg/week dose as the recommended dose is not clear since the efficacy in terms of surrogate outcome measures did not differ among the different peginterferon regimens (90, 180 and 270μg/week) and the number of patients who required dose ...
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TY - JOUR. T1 - Injectable cartilage using polyethylene oxide polymer substrates. AU - Sims, C. Derek. AU - Butler, Peter E.M.. AU - Casanova, Rene. AU - Lee, Betty T.. AU - Randolph, Mark A.. AU - Lee, W. P.Andrew. AU - Vacanti, Charles A.. AU - Yaremchuk, Michael J.. PY - 1996/10. Y1 - 1996/10. N2 - This study demonstrates that polyethylene oxide gels, which are biocompatible and biodegradable synthetic polymers, can be utilized for the encapsulation of isolated chondrocytes and maintenance of three-dimensional spatial support for new tissue development. Chondrocytes isolated from the glenohumeral and humeroradioulnar joints of a calf were added to a 20% polyethylene oxide solution in Hams F-12 medium to generate a final cellular density of 10 x 106/ml. The polymer-chondrocyte constructs were injected through a 22-gauge needle in 500-μl aliquots subcutaneously in 12 nude mice and incubated for 6 and 12 weeks in vivo. Histologic and biochemical analyses including deoxyribonucleic acid and ...
Polyethylene Glycol,Polyethylene glycol,Polyethylene glycol. Polyethylene glycol ( PEG) is a polyether compound with many applications, from industrial
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As not all patients achieve a sustained response with the standard duration of interferon-based therapy, a current focus of research is to identify ways of increasing the post-treatment response rate to peginterferon alfa-2a. Early studies have shown that additional benefits can be obtained by HBeAg-negative patients when the duration of conventional interferon therapy is extended beyond 1 year.6,7 A pilot study highlighted that the advantages of extension therapy initially observed with conventional interferon were also apparent following treatment with peginterferon alfa-2a.8 It is possible that the pattern of HBsAg decline during treatment may help identify patients for whom extended therapy should be ...
The 24-week analysis from this ongoing 48-week phase IIb clinical trial in treatment-naive HCV patients included data from the following five randomized treatment arms, all involving dosing regimens of valopicitabine, administered once-daily, in combination with pegylated interferon alfa-2a (Pegasys) 180 _g per week: (A, n=34) pegylated interferon beginning on day 8 plus valopicitabine ramping from 400 mg to 800 mg beginning at day 29-32, followed by dosing at 800 mg; (B, n=34) valopicitabine 200 mg beginning on day 1 plus pegylated interferon beginning on day 8; (C, n=34) valopicitabine ramping from 400 mg to 800 mg from day 1-6, followed by dosing at 800 mg plus pegylated interferon beginning on day 8; (D, n=36) valopicitabine 800 mg beginning on day 1 plus pegylated interferon beginning on day 8; and (E, n=35) valopicitabine 800 mg plus pegylated interferon, both beginning on day 1 ...
Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for Ethyleneglycol diglycidyl ether (CAS No. 2224-15-9)
Life-threatening and fatal neuropsychiatric reactions may occur with peginterferon alfa-2b use, including suicide, suicidal ideation, homicidal ideation and depression.. Depression was reported by 59% of patients in clinical trials. Post-marketing neuropsychiatric reactions have also been reported, including hallucinations, psychosis, aggression, bipolar mania and encephalopathy. Patients taking peginterferon alfa-2b should be advised to report any of these symptoms to their health care provider, and providers should monitor their patients for these symptoms. Suicidal or homicidal ideation should result in immediate discontinuation of peginterferon alfa-2b.). Additional serious adverse events associated with peginterferon alfa-2b treatment include:. ...
Currently, micro RNA (miRNA) is considered an attractive target for therapeutic intervention. A significant obstacle to the miRNA-based treatments is the efficient delivery of miRNA to the target tissue. We have developed polyethylene glycol-modified liposomes (Bubble liposomes (BLs)) that entrap ul …
Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. ...
TY - JOUR. T1 - Steric stabilization of poly-L-lysine/DNA complexes by the covalent attachment of semitelechelic poly[N-(2-hydroxypropyl)methacrylamide]. AU - Oupicky, David. AU - Howard, Kenneth A.. AU - Koňák, Čestmír. AU - Dash, Philip R.. AU - Ulbrich, Karel. AU - Seymour, Leonard W.. PY - 2000/7/1. Y1 - 2000/7/1. N2 - The concept of steric stabilization was utilized for self-assembling polyelectrolyte poly-L-lysine/DNA (pLL/DNA) complexes using covalent attachment of semitelechelic poly[N-(2-hydroxypropyl)methacrylamide] (pHPMA). We have examined the effect of coating of the complexes with pHPMA on their physicochemical stability, phagocytic uptake in vitro, and biodistribution in vivo. The coated complexes showed stability against aggregation in 0.15 M NaCl and reduced binding of albumin, chosen as a model for the study of the interactions of the complexes with plasma proteins. The presence of coating pHPMA had no effect on the morphology of the complexes as shown by transmission ...
1.Previous studies have indicated that the permeability of polyethyleneglycol across the human intestine is anomalously high in comparison with the permeability of sugars with similar molecular mass. In consequence it has been proposed that two or more distinct mechanisms must exist for the translocation of these classes of molecule or, alternatively, that the molecular parameter determining rate of penetration is each molecules minimum molecular dimension.. 2.The notional hydrogen-bonding capacity of a molecule correlates well with oil-water partition coefficient and also, in a variety of experimental systems, with rate of passive diffusion across biological membranes. A molecules hydrogen-bonding capacity is calculated by inspecting the structural formula and summing the individual theory-derived hydrogen-bonding capacities of the molecules functional groups.. 3.A classic set of intestinal permeability data that includes several ethyleneglycol oligomers and several sugars is re-analysed. A ...
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound ...
Materials and cell culture. 1,2-Dioleoyl-sn-glycero-3-phosphocholine, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, N-hexanoyl-d-erythro-sphingosine (C6), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy polyethylene glycol-2000], N-octanoyl-sphingosine-1-[succinyl(methoxy polyethylene glycol-750)] (PEG(750)-C8), N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-d-erythro-sphingosine (NBD-C6), and N,N-dimethyl-d-erythro-sphingosine (DMSph) were purchased from Avanti Polar Lipids (Alabaster, AL). N-hexanoyl-d-erythro-sphingosine [hexanoyl 6-3H] ([3H]C6) was obtained from ARC (St. Louis, MO). Primary antibodies to caveolin-1 and CD31 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) and BD PharMingen (San Jose, CA), respectively. Horseradish peroxidase-conjugated goat anti-rabbit IgG and rhodamine red-X-conjugated goat anti-rat IgG secondary antibodies were obtained from Santa Cruz Biotechnology and Jackson ImmunoResearch Laboratories, Inc. (West Grove, PA), ...
Protein PEGylation (covalent attachment of poly(ethylene glycol) or PEG to proteins) is an excellent example of a drug delivery system that improves pharmacokinetics and pharmacodynamic properties of therapeutics. However, although PEGylation is clinically proven and attracts both scientific and commercial interest, the technique is associated with many process constraints, in particular related to controlling the number of conjugated PEG chains. A novel, solid-phase PEGylation methodology was attempted to overcome the drawbacks of the commonly used solution-phase methods for preparing PEGylated products. The solid-phase PEGylation methodology involved conjugating protein onto a tethered PEG derivative attached onto a solid matrix, followed by hydrolytic cleavage of the PEG chain from the solid matrix under mild conditions to yield PEGylated protein in free solution. PEGs with molecular weights (MWs) 2000 and 4000 Da were used and a heterobifunctional PEG derivative, α-(β-alanine)-ω-carboxy ...
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Abstract The purpose of this review article is to describe the properties and applications of polyethylene oxide. Polyethylene oxide is a biocompatible polymer, which is marketed as
Recently, a new radioimmunoassay--the polyethylene glycol (PEG) assay--was introduced to measure antibodies to double-stranded (ds) DNA. In this method, polyethylene glycol precipitation of formed 3H-DNA/antiDNA complexes is used instead of the ammonium sulfate precipitation used in the Farr assay. …
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sodium lauryl ether sulfate sles 70%, CAS No. 68585-34-2 Specification sodium lauryl ether sulfate SLES CAS NO. 68585-34-2 C12H26Na2O5S best price Product Name Sodium lauryl ether sulfate Synonyms SODIUM LAURYL ETHER SULFATE;NAXOLATE...
Fabrication and Properties of Polyethylene Glycol-Modified Wood Composite for Energy Storage and Conversion. Yun Li,a Xianjun Li,a,* Dandan Liu,b Xiyi Cheng,a Xia He,a Yiqiang Wu,a Xingong Li,a and Qiongtao Huang c. Green fir wood (Pseudotsuga menziesii) was modified with polyethylene glycol (PEG) to produce wood composites for energy storage and conversion. The PEG-modified wood composites were evaluated based on their dimensional stability, durability, and thermal properties by various analytical methods. The differential scanning calorimetry (DSC) results showed the melting temperature and the latent heat of the phase change material (PCM) composite were 26.74 °C and 73.59 J/g, respectively. Thermal cycling tests and thermogravimetric analysis confirmed the composite exhibited good thermal stability, reliability, and chemical stability. All treated specimens were free from noticeable defects, and the addition of a surface varnish coating prevented PEG from leaching. The PEG-modified ...
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Definition of polyethylene glycol electrolyte for gastrointestinal lavage solution in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is polyethylene glycol electrolyte for gastrointestinal lavage solution? Meaning of polyethylene glycol electrolyte for gastrointestinal lavage solution as a legal term. What does polyethylene glycol electrolyte for gastrointestinal lavage solution mean in law?
TY - JOUR. T1 - Synthesis of silver nanoparticles stabilized by carboxylated methoxypolyethylene glycols. T2 - the role of carboxyl terminal groups in the particle size and morphology. AU - Titkov, Alexander I.. AU - Logutenko, Olga A.. AU - Gerasimov, Evgeny Yu. AU - Shundrina, Inna K.. AU - Karpova, Elena V.. AU - Lyakhov, Nikolay Z.. N1 - Publisher Copyright: © 2019, Springer Nature B.V. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.. PY - 2019/8/15. Y1 - 2019/8/15. N2 - In this work the effect of the synthesis conditions on the size and morphology of the nanoparticles obtained via the reduction of silver ions by benzyl alcohol in the presence of carboxylated methoxypolyethylene glycols with different molecular weights (mPEG-COOH 350, containing a terminal carboxyl group, MW ~ 350 and 2-[2-(2-methoxyethoxy)ethoxy]acetic acid (MEEAA), MW ~ 200) and non-carboxylated mPEG 350 has been studied. The synthesized nanoparticles were characterized by means of X-ray diffraction (XRD), ...
Buy this report (Price 2900 USD for a single-user license) @ https://www.marketgrowthreports.com/purchase/17242744. Major Points from Table of Contents:. 1 Study Coverage. 1.1 Polyvinyl Alcohol Polyethylene Glycol Graft Copolymer Product. 1.2 Key Market Segments in This Study. 1.3 Key Manufacturers Covered. 1.4 Market by Type. 1.4.1 Global Polyvinyl Alcohol Polyethylene Glycol Graft Copolymer Market Size Growth Rate by Type. 1.5 Market by Application. 1.5.1 Global Polyvinyl Alcohol Polyethylene Glycol Graft Copolymer Market Size Growth Rate by Application. 1.6 Study Objectives. 1.7 Years Considered. 2 Executive Summary. 2.1 Global Polyvinyl Alcohol Polyethylene Glycol Graft Copolymer Production. 2.1.1 Global Polyvinyl Alcohol Polyethylene Glycol Graft Copolymer Revenue 2014-2026. 2.1.2 Global Polyvinyl Alcohol Polyethylene Glycol Graft Copolymer Production 2014-2026. 2.1.3 Global Polyvinyl Alcohol Polyethylene Glycol Graft Copolymer Capacity 2014-2026. 2.1.4 Global Polyvinyl Alcohol Polyethylene ...
The purpose of this study is to determine if 24 weeks of treatment with Pegylated Interferon Lambda plus Ribavirin and 12 weeks of treatment with Pegylated Interferon Lambda plus Ribavirin and Daclatasvir will be safe and effective for treatment of hepatitis C compared to 24 weeks of treatment with Pegylated Interferon Alfa-2a plus Ribavirin.. ...
A combination of weekly pegylated interferon (peginterferon) alpha and daily ribavirin represents the standard of care for the treatment of chronic hepatitis C according to current guidelines. It is not established which of the two licensed products (peginterferon alpha-2a or peginterferon alfa-2b) is most effective. We performed a systematic review of head-to-head randomized trials to assess the benefits and harms of the two treatments. We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and LILACS through July 2009. Using standardized forms, two reviewers independently extracted data from each eligible trial report. We statistically combined data using a random effects meta-analysis according to the intention-to-treat principle. We identified 12 randomized clinical trials, including 5,008 patients, that compared peginterferon alpha-2a plus ribavirin versus peginterferon alfa-2b plus ribavirin. Overall, peginterferon alpha-2a significantly increased the number of ...
It is unknown if polyethylene glycol electrolyte solution passes through breast milk. This eMedTV page explains that no studies have been done on using polyethylene glycol electrolyte solution while breastfeeding, and why problems are probably unlikely.
Polyethylene glycol electrolyte solution is a laxative solution that increases the amount of water in the intestinal tract to stimulate bowel movements. This medication also contains potassium, sodium, and other minerals to replace electrolytes that are passed from the body in the stool. Polyethylene glycol electrolyte...
Although HCV-monoinfected patients with an HCV genotype of 1 can expect a 40-45% chance of an SVR using pegylated interferon/ribavirin, HIV/HCV-coinfected patients with genotype-1 are looking at an SVR of 14% (ACTG) to 29% (Apricot). The results in co-infected patients with genotypes 2/3 infections were encouraging with 45% (Ribavic) to 62% (Apricot) SVRs. However, it is important to note that all patients received 48 weeks of therapy. It is likely that, in order to achieve an optimal response, all genotype 2/3 HIV/HCV co-infected patients should receive 48 weeks of treatment with pegylated interferon/ribavirin.. HCV-RNA was associated with treatment outcome in Apricot, but not Ribavic. Analysis, especially for patients with genotype -1 co-infections, by baseline viral loads were not available. It is likely that those with high HCV viral loads (800,000 iu/l) will have poor responses. Although, baseline CD4 counts have been shown to affect response to therapy, patients in both Ribavic and Apricot ...
TY - JOUR. T1 - Adefovir dipivoxil and pegylated interferon alpha for the treatment of chronic hepatitis B. T2 - an updated systematic review and economic evaluation. AU - Shepherd, J. AU - Jones, Jeremy. AU - Baxter, L. AU - Gospodarevskaya, E. AU - Hartwell, D. AU - Harris, P. AU - Price, A. PY - 2009/7. Y1 - 2009/7. N2 - OBJECTIVE: To update and extend a 2006 report on the clinical effectiveness and cost-effectiveness of adefovir dipivoxil (ADV) and pegylated interferon alpha (PEG-alpha) for the treatment of chronic hepatitis B (CHB).DATA SOURCES: Thirteen bibliographic databases were searched including MEDLINE, EMBASE and the Cochrane Library. Searches were run from the beginning of 2005 to September 2007.REVIEW METHODS: For the clinical effectiveness review, randomised controlled trials (RCTs) comparing ADV, PEG-alpha-2a and PEG-alpha-2b with currently licensed treatments for CHB, including non-pegylated interferon alpha (IFN-alpha) and lamivudine (LAM), were included. Outcomes included ...
BACKGROUND: Any benefit of adjuvant interferon alfa-2b for melanoma could depend on dose and duration of treatment. Our aim was to determine whether pegylated interferon alfa-2b can facilitate prolonged exposure while maintaining tolerability. METHODS: 1256 patients with resected stage III melanoma were randomly assigned to observation (n=629) or pegylated interferon alfa-2b (n=627) 6 mug/kg per week for 8 weeks (induction) then 3 mug/kg per week (maintenance) for an intended duration of 5 years. Randomisation was stratified for microscopic (N1) versus macroscopic (N2) nodal involvement, number of positive nodes, ulceration and tumour thickness, sex, and centre. Randomisation was done with a minimisation technique. The primary endpoint was recurrence-free survival. Analyses were done by intention to treat. This study is registered with ClinicalTrials.gov, number NCT00006249. FINDINGS: All randomised patients were included in the primary efficacy analysis. 608 patients in the interferon group and ...
BACKGROUND Data are limited on the efficacy and safety of pegylated interferon plus ribavirin for patients with hepatitis C virus genotype 1 (HCV-1) receiving hemodialysis. OBJECTIVE To compare the efficacy and safety of combination therapy with pegylated interferon plus low-dose ribavirin and pegylated interferon monotherapy for treatment-naive patients with HCV-1 receiving hemodialysis. DESIGN Open-label, randomized, controlled trial. (ClinicalTrials.gov: NCT00491244). SETTING 8 centers in Taiwan. PATIENTS 205 treatment-naive patients with HCV-1 receiving hemodialysis. INTERVENTION 48 weeks of pegylated interferon-α2a, 135 µg weekly, plus ribavirin, 200 mg daily (n = 103), or pegylated interferon-α2a, 135 µg weekly (n = 102). MEASUREMENTS Sustained virologic response rate and adverse event-related withdrawal rate. RESULTS Compared with monotherapy, combination therapy had a greater sustained virologic response rate (64% vs. 33%; relative risk, 1.92 [95% CI, 1.41 to 2.62]; P | 0.001).
Looking for online definition of peginterferon alfa-2a in the Medical Dictionary? peginterferon alfa-2a explanation free. What is peginterferon alfa-2a? Meaning of peginterferon alfa-2a medical term. What does peginterferon alfa-2a mean?
Antibodies against polyethylene glycol (PEG) in healthy subjects raise concerns about the efficacy of pegylated drugs. We evaluated the prevalence of antibodies against PEG among patients with acute lymphoblastic leukemia (ALL) prior to and/or immediately after their first dose of pegylated E.coli asparaginase (PEG-ASNase). Serum samples of 701 children, 673 with primary ALL, 28 with relapsed ALL, and 188 adults with primary ALL were analyzed for anti-PEG IgG and IgM. Measurements in 58 healthy infants served as reference to define cut-points for antibody-positive and -negative samples. Anti-PEG antibodies were detected in ALL patients prior the first PEG-ASNase with a prevalence of 13.9% (anti-PEG IgG) and 29.1% (anti-PEG IgM). After administration of PEG-ASNase the prevalence of anti-PEG antibodies decreased to 4.2% for anti-PEG IgG and to 4.5% for anti-PEG IgM. Pre-existing anti-PEG antibodies did not inhibit PEG-ASNase activity but significantly reduced PEGASNase activity levels in a ...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject-specific sections.
Medscape - Bowel prep dosing for MoviPrep, PlenVu (polyethylene glycol/electrolytes/sodium ascorbate/ascorbic acid), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
TY - JOUR. T1 - Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil®). T2 - Possible role in hypersensitivity reactions. AU - Chanan-Khan, Asher. AU - Szebeni, J.. AU - Savay, S.. AU - Liebes, L.. AU - Rafique, N. M.. AU - Alving, C. R.. AU - Muggia, F. M.. PY - 2003/9/1. Y1 - 2003/9/1. N2 - Background: Pegylated liposomal doxorubicin (Doxil®) has been reported to cause immediate hypersensitivity reactions (HSRs) that cannot be explained as IgE-mediated (type I) allergy. Previous in vitro and animal studies indicated that activation of the complement (C) system might play a causal role in the process, a proposal that has not been tested in humans to date. Patients and methods: Patients with solid tumors (n = 29) treated for the first time with Doxil were evaluated for HSRs and concurrent C activation. HSRs were classified from mild to severe, while C activation was estimated by serial measurement of plasma C terminal complex (SC5b-9) levels. Increases in ...
Synonyms for adenosine deaminase conjugated with polyethylene glycol in Free Thesaurus. Antonyms for adenosine deaminase conjugated with polyethylene glycol. 2 words related to adenosine: biochemistry, nucleoside. What are synonyms for adenosine deaminase conjugated with polyethylene glycol?
Methoxy polyethylene glycol-epoetin beta injection causes the bone marrow to produce red blood cells. If the body does not produce enough red blood cells, severe anemia can occur. This often occurs in people with chronic kidney failure whose kidneys are not working properly. This medicine is available only with your doctors prescription. This product is available in the following dosage forms:. ...
TY - JOUR. T1 - Effect of hemoglobin (Hb) maintenance of subcutaneous (SC) or intravenous (IV) C. E. R. A. (Continuous Erythropoietin Receptor Activator) in chronic kidney disease (CKD) patients not on dialysis. AU - Yuzawa, Yukio. AU - Hotta, Osamu. AU - Suzuki, Hiromichi. AU - Oishi, Tetsuya. AU - Mochizuki, Takahiro. AU - Wakasa, Mikio. AU - Uda, Susumu. AU - Kanno, Yutaka. AU - Horikawa, Kazuhiro. AU - Hara, Soshun. AU - Ichida, Shizunori. AU - Morozumi, Kunio. AU - Shimizu, Hideaki. AU - Tsuyuki, Mikito. AU - Tamai, Hirofumi. AU - Asada, Hiroaki. AU - Naruse, Tomohiko. AU - Inaguma, Daijyo. AU - Suzuki, Satoshi. AU - Kasuga, Hirotake. AU - Ishimura, Eiji. AU - Imai, Enyu. AU - Yamauchi, Atsushi. AU - Saika, Yasushi. AU - Saito, Yoshihiko. AU - Taki, Masafumi. AU - Kawanishi, Hideki. AU - Minakuchi, Jun. AU - Yuasa, Kenji. AU - Miyake, Susumu. AU - Takeda, Kazuhito. AU - Yasunaga, Chikao. AU - Okuda, Seiya. AU - Nakamoto, Masahiko. AU - Saito, Takao. AU - Tsuruya, Kazuhiko. AU - Hirakata, ...
Glycol: any of a class of organic chemicals characterized by having separate two hydroxyl (-OH) groups, contribute to high water solubility, hygroscopicity and reactivity with many organic compounds, on usually linear and aliphatic carbon chain. The general formula is CnH2n(OH)2 or (CH2)n(OH)2. The wider meaning names include diols, dihydric alcohols, and dihydroxy alcohols. Polyethylene glycols and polypropylene glycols are sometimes called polyglycols which are derived by polymerization of ethylene oxide and propylene oxide respectively. Polyethylene glycols are water-soluble at all molecular weights, but polypropylene glycols become increasingly less water-soluble at high molecular weights. Ethylene glycol, HOCH2CH2OH, is the simplest member of the glycol family. Mono-, di- and triethylene glycols are the first three members of a homologous series of dihydroxy alcohols. They are colourless, essentially odourless stable liquids with low viscosities and high boiling points. Ethylene glycol is a ...
Glycol: any of a class of organic chemicals characterized by having separate two hydroxyl (-OH) groups, contribute to high water solubility, hygroscopicity and reactivity with many organic compounds, on usually linear and aliphatic carbon chain. The general formula is CnH2n(OH)2 or (CH2)n(OH)2. The wider meaning names include diols, dihydric alcohols, and dihydroxy alcohols. Polyethylene glycols and polypropylene glycols are sometimes called polyglycols which are derived by polymerization of ethylene oxide and propylene oxide respectively. Polyethylene glycols are water-soluble at all molecular weights, but polypropylene glycols become increasingly less water-soluble at high molecular weights. Ethylene glycol, HOCH2CH2OH, is the simplest member of the glycol family. Mono-, di- and triethylene glycols are the first three members of a homologous series of dihydroxy alcohols. They are colourless, essentially odourless stable liquids with low viscosities and high boiling points. Ethylene glycol is a ...
0034] Suitable non-limiting examples to polyethyleneglycols and polypropyleneglycols are PEG-4, PEG-6, PEG-7, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18, PEG-20, PEG-32, PEG-33, PEG-40, PEG-45, PEG-55, PEG-60, PEG-75, PEG-80, PEG-90, PEG-100, PEG-135, PEG-150, PEG-180, PEG-180, PEG-200, PEG-220, PEG-240, PEG-350, PEG-400, PEG-450, PEG-500, PEG-800, PEG-2M, PEG-5M, PEG-7M, PEG-9M, PEG-14M, PEG-20M, PEG-23M, PEG-25M, PEG-45M, PEG-65M, PEG-90M, PEG-115M, PEG-160M, PEG-180M, PPG-3, PPG-7, PPG-9, PPG-12, PPG-13, PPG-15, PPG-16, PPG-17, PPG-20, PPG-26, PPG-30, PPG-33, PPG-34, PPG-51, PPG-52, and PPG-69. Preferred are PEG-10, PEG-12, PEG-14, PEG-16, PEG-18, PEG-20, PEG-32, PEG-33, PEG-40, PEG-45, PEG-55, PEG-60, PEG-75, PEG-80, PEG-90, PEG-100, PEG-135, PEG-150, PPG-12, PPG-13, PPG-15, PPG-16, PPG-17, PPG-20, PPG-26, PPG-30, PPG-33, PPG-34, PPG-51, PPG-52, and PPG-69. More preferred are PEG-12, PEG-14, PEG-16, PEG-18, PEG-20, PEG-32, PEG-33, PEG-40, PEG-45, PEG-55, PEG-60, PEG-75, PEG-80, ...
TY - JOUR. T1 - Changes in T-cell subsets in HIV-HCV-coinfected patients during pegylated interferon-α2a plus ribavirin treatment. AU - Massanella, Marta. AU - Tural, Cristina. AU - Papagno, Laura. AU - Garcia, Elisabet. AU - Jou, Antoni. AU - Bofill, Margarita. AU - Autran, Brigitte. AU - Clotet, Bonaventura. AU - Blanco, Julià. PY - 2010/1/1. Y1 - 2010/1/1. N2 - Background: We evaluated the effect of different doses of pegylated interferon (PEG-IFN)-α2a/ribavirin (RBV) on several T-cell activation markers in HIV-HCV-coinfected patients and their relationship with changes in plasma HCV RNA. Methods: Frozen peripheral blood mononuclear cells (PBMCs) from 22 patients receiving two different PEG-IFN-α2a schedules were analysed by six-colour flow cytometry. Cell-surface expression of CD38 was quantified. HIV and HCV viral loads, as well as absolute CD4+ and CD8+ T-cell counts, were recorded during the follow up (72 weeks). Results: PEG-IFN-α2a/RBV treatment decreased the absolute numbers of ...
BARCELONA, Spain, Apr 19, 2012 (BUSINESS WIRE) --Gilead Sciences, Inc. (Nasdaq:GILD) today announced interim data from a Phase 2 trial (ATOMIC) examining a 12-week course of treatment with the once-daily nucleotide GS-7977 plus pegylated interferon (Peg-IFN) and ribavirin (RBV) in treatment-naïve patients with genotype 1 chronic hepatitis C virus (HCV) infection. The study found that 90 percent of patients (n=47/52, missing data equals failure analysis) achieved a 12-week sustained virologic response (SVR12), defined as maintaining undetectable viral load (HCV RNA ,25 IU/mL) 12 weeks after the completion of therapy. These findings will be presented today during an oral session at the 47th Annual Meeting of the European Association for the Study of the Liver (International Liver Congress 2012) in Barcelona, Spain. These data suggest that this GS-7977-based regimen could offer most patients with genotype 1 a simple, short, three-month course of treatment with very high cure rates, said Kris ...
Three PEG molecules (PEG-methacrylate, -diacrylate and -dimethacrylate) were incorporated into galactose-based polyacrylate hydrogels and their relative abilities to reduce non-specific protein adsorption in immunoassays were determined. Highly crosslinked hydrogels containing amine-terminated functionalities were formed and used to covalently attach antibodies specific for staphylococcal enterotoxin B (SEB). Patterned arrays of immobilized antibodies in the PEG-modified hydrogels were created with a PDMS template containing micro-channels for use in sandwich immunoassays to detect SEB. Different concentrations of the toxin were applied to the hydrogel arrays, followed with a Cy3-labeled tracer antibody specific for the two toxins. Fluorescence laser scanning confocal microscopy of the tracer molecules provided both qualitative and quantitative measurements on the detection sensitivity and the reduction in non-specific binding as a result of PEG incorporation. Results showed the PEG-modified hydrogel
Comparison of pegylated interferon monotherapy and de novo pegylated interferon plus tenofovir combination therapy in patients with chronic hepatitis B
Under-enrolment of women to randomized clinical trials, including chronic hepatitis C, has long been recognized. The aim of this study was to identify factors predictive of sustained virological response (SVR) to PEG IFN/Ribavirin antiviral therapy in relation to gender and reproductive status of female patients involved. Seven hundred and forty-six treatment-naïve patients (431 men, 315 women) treated with Peg-IFNα-2a (180 μg/week) or Peg-IFNα-2b (1.5 μg/kg/week) plus ribavirin (800-1400 mg/day) for 24 or 48 weeks were studied between 2006 and 2010. Differences in SVR rate, overall and by gender were assessed after adjustment and propensity score matching. SVR was obtained in 44.2% of Peg-IFNα-2a-treated patients and in 51.2% of Peg-IFNα-2b-treated patients (intention-to-treat; P = 0.139). Age, fibrosis stage and genotype 2 and 3 were independently associated with SVR by multivariate analysis. Analysing by gender, the difference in SVR between PEG-IFNα types was not significant in men ...
286578264 - EP 1258560 A1 2002-11-20 - Use of hydrophobically modified polyaminamides with polyethylene glycol esters in paper products - The present invention uses hydrophobically modified polyaminamide with standard wet strength agent to produce a softer and more absorbent paper material. The hydrophobically modified polyaminamide is substantive to cellulosic fibers, thus is able to carry polyethylene glycol esters or ethers, a non-substantive material to cellulosic fiber as stable complexes, into the paper product.[origin: EP1258560A1] The present invention uses hydrophobically modified polyaminamide with standard wet strength agent to produce a softer and more absorbent paper material. The hydrophobically modified polyaminamide is substantive to cellulosic fibers, thus is able to carry polyethylene glycol esters or ethers, a non-substantive material to cellulosic fiber as stable complexes, into the paper product.
TY - JOUR. T1 - Drug Delivery Nanocarriers from a Fully Degradable PEG-Conjugated Polyester with a Reduction-Responsive Backbone. AU - Yameen, Basit. AU - Vilos, Cristian. AU - Choi, Won Il. AU - Whyte, Andrew. AU - Huang, Jining. AU - Pollit, Lori. AU - Farokhzad, Omid C.. PY - 2015/8/1. Y1 - 2015/8/1. N2 - The remarkably high intracellular concentration of reducing agents is an excellent endogenous stimulus for designing nanocarriers programmed for intracellular delivery of therapeutic agents. However, despite their excellent biodegradability profiles, aliphatic polyesters that are fully degradable in response to the intracellular reducing environment are rare. Herein, a reduction-responsive drug delivery nanocarrier derived from a linear polyester bearing disulfide bonds is reported. The reduction-responsive polyester is synthesized via a convenient polycondensation process. After conjugation of terminal carboxylic acid groups of polyester to polyethylene glycol (PEG), the resulting polymer ...
The incorporation of poly(ethylene glycol) (PEG)-conjugated lipids in lipid-based carriers substantially prolongs the circulation lifetime of liposomes. However, the mechanism(s) by which PEG-lipids achieve this have not been fully elucidated. It is believed that PEG-lipids mediate steric stabilization, ultimately reducing surface-surface interactions including the aggregation of liposomes and/or adsorption of plasma proteins. The purpose of the studies described here was to compare the effects of PEG-lipid incorporation in liposomes on protein binding, liposome-liposome aggregation and pharmacokinetics in mice. Cholesterol-free liposomes were chosen because of their increasing importance as liposomal delivery systems and their marked sensitivity to protein binding and aggregation. Specifically, liposomes containing various molecular weight PEG-lipids at a variety of molar proportions were analyzed for in vivo clearance, aggregation state (size exclusion chromatography, quasi-elastic light ...
Peginterferon alfa-2b: Find the most comprehensive real-world treatment information on Peginterferon alfa-2b at PatientsLikeMe. 4 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), amyotrophic lateral sclerosis, epilepsy, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, attention deficit/hyperactivity disorder, bipolar II disorder, asthma, social anxiety disorder, high cholesterol (hypercholesterolemia), irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or psoriasis currently take Peginterferon alfa-2b.
TY - CHAP. T1 - Engineering well-characterized PEG-coated nanoparticles for elucidating biological barriers to drug delivery. AU - Yang,Qi. AU - Lai,Samuel K.. PY - 2017. Y1 - 2017. N2 - Poly(ethylene glycol) (PEG) coatings can substantially reduce nanoparticle uptake and clearance by immune cells as well as nonspecific interactions with the biological environment, thus potentially improving nanoparticle circulation times and biodistribution in target tissues such as tumors. Naturally, the stealth properties of PEG coatings are critically dependent on the density and conformation of surface PEG chains. However, there are significant technical hurdles to both generating sufficiently dense PEG coatings on nanoparticles and precisely characterizing their PEG grafting densities. Here, we describe methods for preparing PEGylated polymeric nanoparticles with precisely tunable PEG coatings without the use of organic solvents, quantifying PEGylation efficiency and density using a standard fluorescence ...
... is the active ingredient of a drug marketed by Hoffmann-La Roche under the brand name ... Methoxy polyethylene glycol-epoetin beta is made from erythropoietin by chemically linking the N-terminal amino group or the ε- ... amino group of any lysine present in the protein with methoxy polyethylene glycol butanoic acid. The average molecular weight ...
... are used to prepare low-molecular-weight polyethylene glycol. Ethylene Propylene glycol Monoethylene glycol Diethylene glycol ... Polyethylene glycol is produced by the interaction of ethylene oxide with water, ethylene glycol, or ethylene glycol oligomers ... Polyethylene glycol, Chemindustry.ru Wikimedia Commons has media related to Poly(ethylene glycol). Wikimedia Commons has media ... Polyethylene oxide, or high-molecular-weight polyethylene glycol, is synthesized by suspension polymerization. It is necessary ...
... or PEG propylene glycol cocoates are chemical compounds produced by the ... PEG-120 Propylene Glycol Stearate, PEG-10 Propylene Glycol, PEG-8 Propylene Glycol Cocoate, and PEG-55 Propylene Glycol Oleate ... Their chemical designation is PEG-8, referring to its polyethylene glycol (PEG) molecular chain length. PEG propylene glycol ... "Final Report on the Safety Assessment of PEG-25 Propylene Glycol Stearate, PEG-75 Propylene Glycol Stearate, ...
... densities and kinematic viscosities of poly(propylene glycol) diglycidyl ether and poly(ethylene glycol) monooleate". The ... "Bulk Modification of Poly(lactide) (PLA) via Copolymerization with Poly(propylene glycol) Diglycidylether (PPGDGE)". Polymers. ... Poly(propylene glycol) diglycidyl ether (PPGDGE) is an organic chemical in the glycidyl ether family. There are a number of ... "Poly(propylene glycol) diglycidyl ether". Sigma Aldrich. Jagtap, Ameya Rajendra; More, Aarti (2022-08-01). "Developments in ...
"Methoxy polyethylene glycol-epoetin beta". Drug Information Portal. U.S. National Library of Medicine. Portal: Medicine ( ... Methoxy polyethylene glycol-epoetin beta (Mircera) Recombinant erythropoietin has a variety of glycosylation patterns giving ...
mono-ethylene glycol, di-ethylene glycol and other poly-ethylene glycols) get unavoidably produced. Thus, in-order to prevent ... Among glycols, ethylene glycol is used as antifreeze, in the production of polyester and polyethylene terephthalate (PET - raw ... Most ethylene oxide is used for synthesis of ethylene glycols, including diethylene glycol and triethylene glycol, that ... Ethylene oxide in presence of water can hydrolyze to ethylene glycol and form polyethylene oxide, which then eventually is ...
Effects of polyethylene glycol". The Journal of Biological Chemistry. 264 (12): 6786-92. doi:10.1016/S0021-9258(18)83498-6. ... Lin HY, Davis PJ, Thacore HR (December 1991). "Production of human interferon-beta by Sendai virus and poly(rI).poly(rC): ... Müthing J (September 1996). "Influenza A and Sendai viruses preferentially bind to fucosylated gangliosides with linear poly-N- ...
"DailyMed - polyethylene glycol 3350 powder, for solution". dailymed.nlm.nih.gov. Retrieved 19 April 2019. "Polyethylene Glycol ... "Polyethylene glycol 3350 Uses, Side Effects & Warnings". Drugs.com. Retrieved 19 April 2019. "The Top 300 of 2020". ClinCalc. ... Macrogol, also known as polyethylene glycol (PEG), is used as a medication to treat constipation in children and adults. It is ... "Polyethylene glycol 3350 Use During Pregnancy". Drugs.com. Retrieved 19 April 2019. Townsend, Courtney M.; Beauchamp, R. Daniel ...
Kawai F, Kimura T, Tani Y, Yamada H, Ueno T, Fukami H (1983). "Identification of reaction-products of polyethylene-glycol ... Other names in common use include polyethylene glycol dehydrogenase, and alkan-1-ol:(acceptor) oxidoreductase. This enzyme ... 1985). "Identification of the prosthetic group and further characterization of a novel enzyme, polyethylene-glycol ...
Conservation included treatment with polyethylene glycol. It was later transferred to Portsmouth where maritime archaeology ...
Fruijtier-Pölloth C (October 2005). "Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic ... Wenande E, Garvey LH (July 2016). "Immediate-type hypersensitivity to polyethylene glycols: a review". Clinical and ... The inclusion of sweet-tasting but toxic diethylene glycol in Chinese-made toothpaste led to a recall in 2007 involving ... The world outcry made Chinese officials ban the practice of using diethylene glycol in toothpaste. Reports have suggested ...
Polyethylene glycol is used to fuse adjacent plasma membranes, but the success rate is low, so a selective medium in which only ... Yang J, Shen MH (2006). Polyethylene glycol-mediated cell fusion. Methods Mol Biol. Vol. 325. pp. 59-66. National Research ...
"BestBETs: Is polyethylene glycol safe and effective for chro..." Retrieved 2007-09-06. Roerig JL, Steffen KJ, Mitchell JE, ... Solutions of polyethylene glycol and electrolytes (sodium chloride, sodium bicarbonate, potassium chloride, and sometimes ... Di Palma JA, Cleveland MV, McGowan J, Herrera JL (2007). "A randomized, multicenter comparison of polyethylene glycol laxative ... "Comparison of a low dose polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation". Gut. ...
Choi, Lewis Siu Leung; Madden, Thomas D.; Webb, Murray S. (1994-09-30). "Polyethylene glycol modified ceramide lipids and ... including the addition of a chemical called polyethylene glycol (PEG) to further increase the LNP's ability to pass into cells ...
... glycol Polyethylene glycol monobutyl ether Polyethylene glycol monomethyl ether Polyethylene oxide Triethylene glycol monobutyl ... Unlike polyethylene glycol based fluids, DOT 5 is hydrophobic. An advantage over other forms of brake fluid is that silicone ... Alkyl ester Aliphatic amine Diethylene glycol Diethylene glycol monoethyl ether Diethylene glycol monomethyl ether Dimethyl ... Any system that has used glycol-based fluid (DOT 3/4/5.1) will contain moisture; glycol fluid disperses the moisture throughout ...
Polyethylene glycols are more commonly used in practical applications. These ligands encapsulate alkali metal cations ( ...
For example, combining lead nitrate and pentaethylene glycol (EO5) in a solution of acetonitrile and methanol followed by slow ... ISBN 978-0-08-037941-8. p. 395 Rogers, Robin D.; Andrew H. Bond; Debra M. Roden (1996). "Structural Chemistry of Poly (ethylene ... glycol). Complexes of Lead(II) Nitrate and Lead(II) Bromide". Inorg. Chem. 35 (24): 6964-6973. doi:10.1021/ic960587b. PMID ...
Immersing flowers in glycerol or polyethylene glycol also lengthens lifespan. 'Bright Bikini' has gained the Royal ...
Cserr HF, Cooper DN, Suri PK, Patlak CS (April 1981). "Efflux of radiolabeled polyethylene glycols and albumin from rat brain ...
Polymers, such as Polyethylene glycol (PEG), Polyallylamine hydrochloride (PAH) coating; dietary fibers, such as chitosan; or ...
"Poly(ethylene glycol) diglycidyl ether (PEGDGE 600)". www.polysciences.com. Retrieved 2020-05-01. Berdasco, Nancy Anne M.; ...
Polyethylene glycol was chosen as the polymer. In 1981 Davis and Abuchowski founded Enzon, Inc., which brought three PEGylated ... In both vaccines, the bubbles are coated with a stabilizing molecule of polyethylene glycol. As of December 2020, there is some ... PEGylation (or pegylation) is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol ( ... Knop, Katrin; Hoogenboom, Richard; Fischer, Dagmar; Schubert, Ulrich S. (23 August 2010). "Poly(ethylene glycol) in Drug ...
If laxatives are used, milk of magnesia or polyethylene glycol are recommended as first-line agents due to their low cost and ... Lee-Robichaud H, Thomas K, Morgan J, Nelson RL (7 July 2010). "Lactulose versus Polyethylene Glycol for Chronic Constipation". ... In cases of chronic constipation, polyethylene glycol appears superior to lactulose. Prokinetics may be used to improve ...
Examples include cellulose, methyl cellulose, polyvinylpyrrolidone and polyethylene glycol. Tablet coatings protect tablet ... sucrose and polyethylene glycol. Dry binders are added to the powder blend, either after a wet granulation step, or as part of ... polyethylene glycol (PEG)... Binders are classified according to their application: Solution binders are dissolved in a solvent ...
Silica nano-particles are dispersed in a solution of polyethylene glycol. The silica particles provide a high-strength material ...
Osmotic laxatives such as polyethylene glycol are preferred. Individuals prone to DIOS tend to be at risk for repeated episodes ...
She developed a range of polyethylene glycol nanoparticles that can be cross-linked using hydrazone and oximes. The choice of ... Maynard has shown it is possible to use the fluorous content of poly(ethylene glycol methyl ether methacrylate), fluorous ... "FDA-approved poly (ethylene glycol)-protein conjugate drugs". Polymer Chemistry. 2 (7): 1442-1448. doi:10.1039/c1py00034a. ...
Kaufmann, Merrill R.; Eckard, Alan N. (1971). "Evaluation of water stress control with polyethylene glycols by analysis of ...
... attached to polyethylene glycol ("PEGylated"). It mimics the structure of erythropoietin, the human glycoprotein which promotes ...
Documented hypersensitivity to polyethylene glycol (PEG) (a very rare allergy) is listed as a contraindication to the COVID-19 ... ALC-0159 is a polyethylene glycol conjugate, i.e., a PEGylated lipid. Pfizer and BioNTech are manufacturing the vaccine in ... polyethylene glycol)-2000]-N,N-ditetradecylacetamide 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) cholesterol dibasic ... A potential role of polyethylene glycol?". Allergy. 76 (6): 1617-1618. doi:10.1111/all.14711. PMID 33320974. S2CID 229284320. " ...
Prune kernel oil - marketed as a gourmet cooking oil Poly vinyl pyrrolidone - Polydextrose - humectant Polyethylene glycol 8000 ... humectant Propylene glycol alginate - thickener, vegetable gum, stabilizer, emulsifier Propylene glycol esters of fatty acids ... preservative Oxidised polyethylene wax - humectant Oxidised starch - thickener, vegetable gum Oxystearin - antioxidant, ... Lactylated fatty acid esters of glycerol and propylene glycol - emulsifier Larch gum - Lard - Latolrubine - color Laurel berry ...
... where the timber went through a seven-year process of impregnation by heated polyethylene glycol (PEG) to enhance dimensional ... undergoing a seven-year process of impregnation by heated polyethylene glycol (PEG). In March 1999, the boat was reassembled ...
... polyethylene glycol is linked to the interferon molecule to make the interferon last longer in the body. Approval for PEGylated ...
... polyethylene glycol, talc, and a distinct color additive (carmine high tint in the 150 mg tablets and iron oxide red in the 200 ...
Ethylene glycol, a liquid, was used to manufacture polyethylene terephthalate resins (PET) for the bottling industry, ... They also developed a novel fixed-bed oxidation process for production of ethylene glycol. Landau and his colleagues licensed ... Ethylene oxide, a gas, was used for synthesis of ethylene glycol. ... where the first production-scale ethylene oxide and ethylene glycol plant was built. Scientific Design was not the first ...
For example, in the synthesis of PET, a small fraction of the ethylene glycol can be replaced by glycerol which has three ... Consider the example of polyethylene terephthalate (PET or "polyester"). The monomers which could be used to create this ... polymer are ethylene glycol and terephthalic acid: HO-CH2-CH2-OH and HOOC-C6H4-COOH In the polymer, there are two structural ...
One approach to antifouling entails coating surfaces with polyethylene glycol (PEG). Growing chains of PEG on surfaces is ... high-density polyethylene and polymethylmethacrylate ("plexiglas") demonstrate a high correlation between their resistance to ...
... sodium picosulphate with magnesium citrate versus sulphate-free polyethylene glycol lavage solution". The American Journal of ...
Weinfeld M, Xing JZ, Lee J, Leadon SA, Cooper PK, Le XC (2001). "Factors influencing the removal of thymine glycol from DNA in ... studied the level of a particular enzyme, Poly ADP ribose polymerase, which is involved in repair of single-strand breaks in ... Bürkle, A; Brabeck, C; Diefenbach, J; Beneke, S (May 2005). "The emerging role of poly(ADP-ribose) polymerase-1 in longevity". ... Muiras ML, Müller M, Schächter F, Bürkle A (1998). "Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines ...
2009). "Prevention of Carbon Nanohorn Agglomeration Using a Conjugate Composed of Comb-Shaped Polyethylene Glycol and a Peptide ...
The addition of polyethylene glycol (PEG) causes fusion without significant aggregation or biochemical disruption. This ... Pannuzzo, Martina; Jong, De; Djurre, H.; Raudino, Antonio; Marrink Siewert, J. (2014). "Simulation of polyethylene glycol and ... A DNA hairpin composed of 5 base pair stem and poly-thymidine loop that is labeled with a donor (Cy3) and an acceptor (Cy5) at ... We separately encapsulated multiple unlabeled poly-adenosine DNA strands in the t-SNARE vesicle. If the two vesicles, both ~100 ...
Frequently, peptide linkers are used, but polyethylene glycol and small molecules linkers also exist. The linkers enable the ...
In August 2019, the first of two new polyethylene plants had begun operating. The second plant and cracker were scheduled to ... Branded as "The Sunshine Project," the complex, made up of 14 facilities, including 10 plants, would produce ethylene glycol, ... In May 2018, citing stronger demand in the co-polymer market, Formosa Plastics announced new expansions in polyethylene and ... Pipoli, Renzo (29 January 2020). "PU: U.S. Gulf Coast polyethylene projects face start-up delays". Business & Industry ...
A soluble initiator O,O′-bis(2-aminoethyl)polyethylene glycol (diaminoPEG) for poly-leucine assembly was utilized to generate a ... these include poly-leucine and poly-alanine. Both poly-L- and poly-D-amino acids are available and cause the opposite ... Furthermore, in biphasic systems the polymer may be immobilized on polystyrene, polyethylene glycol (PEG), or silica gel and ... β-Unsaturated Ketones Using a Soluble Triblock Polyethylene Glycol−Polyamino Acid Catalyst". Org. Lett. 3 (5): 683-6. doi: ...
... polyethylene glycols MeSH D25.720.741.250 - cetomacrogol MeSH D25.720.741.485 - hydrogel MeSH D25.720.741.575 - nonoxynol MeSH ... polyethylenes MeSH D25.720.716.507.500 - polyethylene MeSH D25.720.716.507.600 - polyethyleneimine MeSH D25.720.716.550 - ... Polyethylene terephthalates MeSH D25.720.728.772 - polyglactin 910 MeSH D25.720.728.780 - polyglycolic acid MeSH D25.720.741 - ...
... graft-Poly(ethylene glycol) in Aqueous Glycerol Mixtures" (PDF). Tribology Letters. 37 (3): 541-552. doi:10.1007/s11249-009- ... Group IV - Polyalphaolefins (PAO) Group V - All others not included above, such as naphthenics, polyalkylene glycols (PAG), and ... Nalam, Prathima C.; Clasohm, Jarred N.; Mashaghi, Alireza; Spencer, Nicholas D. (2010). "Macrotribological Studies of Poly(L- ... Synthetic esters Polyalkylene glycols (PAG) Phosphate esters Perfluoropolyether (PFPE) Alkylated naphthalenes (AN) Silicate ...
It cleaves Mono-(2-hydroxyethyl)terephthalic acid, the PET degradation product by PETase, to ethylene glycol and terephthalic ... March 2016). "A bacterium that degrades and assimilates poly(ethylene terephthalate)". Science. 351 (6278): 1196-9. doi:10.1126 ... MHETase hydrolyses the ester bond of MHET forming terephthalic acid and ethylene glycol. Besides its natural substrate MHET the ...
Many razor cartridges include a lubricating strip, made of polyethylene glycol, to function instead of or in supplement to ...
The addition of polyethylene glycol (PEG) causes fusion without significant aggregation or biochemical disruption. This ... The most significant advance in this area was the grafting of polyethylene glycol (PEG) onto the liposome surface to produce " ...
Xi J, Wang X, Li S, Zhou X, Yue L, Fan J, Hao D (November 2006). "Polyethylene glycol fractionation improved detection of low- ... Kim ST, Cho KS, Jang YS, Kang KY (June 2001). "Two-dimensional electrophoretic analysis of rice proteins by polyethylene glycol ... gel electrophoresis with polyethylene glycol, affinity chromatography, and aggregation using DTT, though these methods are more ...
Threose nucleic acid (TNA) has also been proposed as a starting point, as has glycol nucleic acid (GNA), and like PNA, also ... Joyce GF, Visser GM, van Boeckel CA, van Boom JH, Orgel LE, van Westrenen J (1984). "Chiral selection in poly(C)-directed ... Suggestions for 'simple' pre-RNA nucleic acids have included peptide nucleic acid (PNA), threose nucleic acid (TNA) or glycol ...
... s with recombinant DNA are introduced into the media containing animal cells and are fused by polyethylene glycol ( ...
Poly(ether thiourea) shows excellent mechanical robustness (Young's modulus E = 1.4 GPa) due to the dense, non-linear hydrogen- ... ethylene glycol)-appended amphiphilic porphyrin and confirmed its 1D assembly in aqueous media. In addition to this pioneering ... poly(ether thiourea), is notable as it dispelled a long-term preconception that mechanical robustness and self-healing ... affording extended-chain crystalline polyethylene fibers. He was also the first to discover morphology-dependent energy ...
Some more perylene based organic rectifiers with PEG (polyethylene glycol) swallowtails have been synthesized in Mattern's lab ...
Polyethylene glycol and citrates are used for bowel cleansing. Enema Vaginoplasty Hung, Shih-Ya; Chen, Hong-Chang; Chen, ... "A Randomized Trial Comparing the Bowel Cleansing Efficacy of Sodium Picosulfate/Magnesium Citrate and Polyethylene Glycol/ ...
For polyethylene oxide non ionic surfactants the HLB is defined by the Griffin's scale (Equation 1): H L B = 20 × ( M a s s o f ... The reaction is carried out at 130-135 °C. Propylene glycol is removed through distillation under vacuum at above 120 °C. The ... However, a clear numerical correlation is found between the Griffin HLB scale defined for non-ionic poly(ethylene oxide) (PEO) ... Hence, by using the same calculated HLB scale for sucrose fatty acid esters and for polyethylene surfactants, instead of an ...
The rewriteable paper was made by first coating ordinary paper with a layer of polyethylene glycol (PEG) to prevent it reacting ...
Alternatively, the viral vector can be coated with a polymer such as polyethylene glycol, shielding it from antibodies, but ...
Polyethylene Glycol 3350: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Take polyethylene glycol 3350 exactly as directed.. Polyethylene glycol 3350 may be habit-forming. Do not take a larger dose, ... Before taking polyethylene glycol 3350,. *tell your doctor and pharmacist if you are allergic to polyethylene glycol or any ... Polyethylene glycol 3350 is used to treat occasional constipation. Polyethylene glycol 3350 is in a class of medications called ...
Wadhwa, Meenu; Bird, Chris; Dougall, Tom; Rigsby, Peter; Bristow, Adrian; Thorpe, Robin; WHO Expert Committee on Biological Standardization; World Health Organization (‎World Health Organization, 2013)‎ ...
Wadhwa, Meenu; Bird, Chris; Dougall, Tom; Rigsby, Peter; Bristow, Adrian; Thorpe, Robin; WHO Expert Committee on Biological Standardization; World Health Organization (‎World Health Organization, 2013)‎ ...
POLYETHYLENE GLYCOL 3350 (UNII: G2M7P15E5P) (POLYETHYLENE GLYCOL 3350 - UNII:G2M7P15E5P) POLYETHYLENE GLYCOL 3350. 17 g. ... polyethylene glycol 3350 17 GM Powder for Oral Solution. PSN. 2. 876193. polyethylene glycol 3350 17000 MG Powder for Oral ... Polyethylene Glycol 3350 NF (Polyethylene Glycol 3350. Powder For Oral Solution) is a synthetic polyglycol having an average ... Who should NOT take Polyethylene Glycol 3350 NF Polyethylene Glycol 3350 NF should not be used by children. It should not be ...
Polyglykol 4000 PF is a milled PEG excipient grade powder product with a fine particle size distribution, produced under IPEC GMP conditions.
We use poly ethylene glycol 300, not ethylene glycol - big difference. If you use it, put the discs in a bag and fill the bag ... Stabilizing Wood with Polyethylene Glycol. Advice and explanations about using PEG to prevent shrinkage and cracking in heavy ... I checked on the cost of polyethylene glycol 300 and it is more costly than Pentacryl. I need multiple 55 gallon drums at a ... Ive become focused on polyethylene glycol 1000, mentioned positively by many for stabilization wood for turning projects. ( ...
In this research, a novel biodegradable D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide ... Nanoformulation of D-α tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) diblock copolymer for ... It was reported that at low pH values, docetaxel (DTX) was released from D-α-tocopheryl polyethylene glycol 1000-block-poly(β- ... Nanoparticles of poly(lactide-co-glycolide)-d-a-tocopheryl polyethylene glycol 1000 succinate random copolymer for cancer ...
A formulation for preparing Polyethylene Glycol (PEG) Troches with Suspending Agent (Soft Lozenges). Includes ingredients, ... Abstract: A formulation for preparing Polyethylene Glycol (PEG) Troches with Suspending Agent (Soft Lozenges). Includes ...
... b-poly(ethylene glycol)-b-poly(L-lactide) triblock copolymer (PLLA-PEG-PLLA) is a promising candidate for use as a ... b-poly(ethylene glycol)-b-poly(L-lactide) bioplastics: Effects of poly(ethylene glycol) block length and chain extender. J. ... High-molecular-weight poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) triblock copolymer (PLLA-PEG-PLLA) is a ... Srisuwan Y, Baimark Y. Improvement in Thermal Stability of Flexible Poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) ...
Polyethylene glycol 3350 (USP);. Polyethylene glycol (NF);. Polyethylene oxide (NF);. Macrogol;. PEG;. Lutrol E (TN);. Sentry ... Polyethylene Glycol 3350 NF. D03370 Polyethylene glycol 3350 (USP). Rx-to-OTC switch list in the USA [br08315.html]. D03370. ... D03370 Polyethylene glycol 3350 (USP) ,US,. USP drug classification [BR:br08302]. Gastrointestinal Agents. Anti-Constipation ...
Be the first to review "Poly(ethylene glycol) diacrylate" Cancel reply. Your rating *. Rate…. Perfect. Good. Average. Not that ...
Search of: Methoxy polyethylene glycol-epoetin beta AND ESA AND 12 g AND once monthly - Modify Search. Expert Search ...
Miralax (polyethylene glycol) remains in the gut & is not absorbed into the body, so can safely be used in pregnancy.. Created ... Is miralax (polyethylene glycol) safe to use on a one year d for constipation? Senna isnt working!. 1 doctor answer • 1 doctor ... Is miralax (polyethylene glycol) safe during pregnancy? i used it prior to pregnancy, as i have cronic constipation, but i am ... Is it safe to take miralax (polyethylene glycol) and colace twice a day during pregnancy? My body got used to taking it once a ...
... June 1, ... This scaffold is generated from the cryogelation of poly(ethylene glycol) diacrylate to produce a defined elastic modulus for ...
In 2018, Top exporters of Waxes; artificial and prepared, of polyethylene glycol to Italy were Germany ($7,402.43K , 2,357,500 ... HS Code 340420: Waxes; artificial and prepared, of polyethylene glycol. Please note: Exports is gross exports and Imports is ... Waxes; artificial and prepared, of polyethylene glycol. 2018. Italy. 7,402.43. 2,357,500. Kg. ... Waxes; artificial and prepared, of polyethylene glycol. 2018. Italy. 1,961.50. 1,295,000. Kg. ...
... linked via a suitable selective end-modified poly(ethylene glycol), in an effort to obtain a synergistic effect with improved ... Synthesis and Biological Activity of New Mixed HIV-PR Inhibitors Conjugated to Bifunctional High-Molecular Weight Poly(Ethylene ...
Methoxy polyethylene Glycol-epoetin beta (By injection). Methoxy Polyethylene Glycol-Epoetin Beta (meth-OX-ee pol-ee-ETH-i-leen ... Do not use it if you had an allergic reaction to methoxy polyethylene glycol-epoetin beta. How to Use This Medicine: Injectable ...
Your search for ASCORBIC ACID OR CHLORIDE ION OR POLYETHYLENE GLYCOL 3350 OR POTASSIUM CATION OR SODIUM SULFATE ANHYDROUS did ...
title = "Photoreversible chain extension of poly(ethylene glycol)",. abstract = "Coumarin containing poly(ethylene glycol) ... The coumarin modified poly(ethylene glycol) monols and diols were solution cast into films (1 to 15 μm) and chain extended via ... The coumarin modified poly(ethylene glycol) monols and diols were solution cast into films (1 to 15 μm) and chain extended via ... The coumarin modified poly(ethylene glycol) monols and diols were solution cast into films (1 to 15 μm) and chain extended via ...
chemBlink provides samples of SDS for Polyethylene glycol cetyl ether (CAS # 9004-95-9). Visit our website today in order to ... More information of Polyethylene glycol cetyl ether. Suppliers of Polyethylene glycol cetyl ether. ...
Methoxy polyethylene glycol-epoetin beta - Biologic Drug Details. ⮩ Send this page by email. ✉ Email this page to a colleague ... 3) Low Certainty: US Patents for methoxy polyethylene glycol-epoetin beta Derived from Patent Text Search. No patents found ... 1) High Certainty: US Patents for methoxy polyethylene glycol-epoetin beta Derived from Brand-Side Litigation. No patents found ... Recent Clinical Trials for methoxy polyethylene glycol-epoetin beta. Identify potential brand extensions & biosimilar entrants ...
Poly(citric acid)-block-poly(ethylene glycol) copolymers. A. Tavakoli, M. Vosoughi, M. Adeli - 2010. ... Linear-dendritic ABA triblock copolymers containing poly(ethylene glycol) (PEG) as B block and hyperbranched poly(citric acid ... ethylene glycol) (PEG) as B block and hyperbranched poly(citric acid) (PCA) as A blocks for future applications in nanomedicine ... This manuscript investigates the potentials of linear-dendritic ABA triblock copolymers containing poly( ...
"Chlorpyrifos-loaded Silver/Polyethylene Glycol/Chitosan Nanocomposite: Improved Termiticidal Activity against Microcerotermes ... Chlorpyrifos-loaded Silver/Polyethylene Glycol/Chitosan Nanocomposite: Improved Termiticidal Activity against Microcerotermes ... Chlorpyrifos-loaded Silver/Polyethylene Glycol/Chitosan Nanocomposite: Improved Termiticidal Activity against Microcerotermes ... 1399). Chlorpyrifos-loaded Silver/Polyethylene Glycol/Chitosan Nanocomposite: Improved Termiticidal Activity against ...
HILIC separation of polyethylene glycol can be used to determine polyethylene glycol content in various formulations using ELSD ... Polyethylene glycol (PEG) has low toxicity and is used in a variety of products (creams, laxatives, lubricants). When attached ... polyethylene glycol allows a slowed clearance of the carried protein from the blood. This makes for a longer acting medicinal ...
T1 - Poly(L-lysine)-graft-Poly(ethylene glycol) (PLL-g-PEG): A universal aqueous lubricant additive for tribosystem involving ... Poly(L-lysine)-graft-Poly(ethylene glycol) (PLL-g-PEG): A universal aqueous lubricant additive for tribosystem involving ... title = "Poly(L-lysine)-graft-Poly(ethylene glycol) (PLL-g-PEG): A universal aqueous lubricant additive for tribosystem ... Poly(L-lysine)-graft-Poly(ethylene glycol) (PLL-g-PEG): A universal aqueous lubricant additive for tribosystem involving ...
Effect of polyethylene glycol versus lactulose on abdominal pain in children occult constipation: a randomized controlled study ... However, no study has compared effect of poly ethylene glycol (PEG) and lactulose on occult constipation. Materials and methods ... Citar como: Hakimzadeh M, Mottaghi S, Ahmadi M, Javaherizadeh H. Effect of polyethylene glycol versus lactulose on abdominal ... A randomised, double- blind study of polyethylene glycol 4000 and lactulose in the treatment of constipation in children. BMC ...
Methoxy polyethylene glycol-epoetin beta - Searchable synonyms, formulas, resource links, and other chemical information. ... Substance Name: Methoxy polyethylene glycol-epoetin beta. RN: 677324-53-7. UNII: LR3UXN0193. Note. *. A third-generation ... the methoxy-polyethylene glycol polymer chain is integrated via amide bonds between the N-terminal amino group or the e-amino ...
Polyethylene glycol 400 is an ingredient used in a wide variety of medications, and is not an approved medication. ... Polyethylene glycol 400 (45 g/100g) + Polyethylene glycol (55 g/100g). Cream. Topical. Biocellerex, Inc.. 2015-07-14. 2016-01- ... Polyethylene glycol 400 (PEG 400) is a low-molecular-weight grade of polyethylene glycol with a low-level toxicity. It is very ... Polyethylene glycol 400. DrugBank Accession Number. DB11077. Background. Polyethylene glycols (PEGs) are products made of ...
Effect of Various Levels of Available Water on Germination of Polyethylene Glycol (PEG) Pretreated or Untreated Tomato Seeds in ...
  • We use poly ethylene glycol 300, not ethylene glycol - big difference. (woodweb.com)
  • What are your costs of the Poly Ethylene Glycol 1000? (woodweb.com)
  • High-molecular-weight poly(L-lactide)- b -poly(ethylene glycol)- b -poly(L-lactide) triblock copolymer (PLLA-PEG-PLLA) is a promising candidate for use as a biodegradable bioplastic because of its high flexibility. (mdpi.com)
  • This scaffold is generated from the cryogelation of poly(ethylene glycol) diacrylate to produce a defined elastic modulus for prostate tumor growth. (urotoday.com)
  • We have synthesized and evaluated a small set of dual action HIV-Protease inhibitors, consisting of a catalytic site reversible inhibitor conjugated with a dimerization peptidic inhibitor, linked via a suitable selective end-modified poly(ethylene glycol), in an effort to obtain a synergistic effect with improved biological behaviour and more powerful pharmacological features, such as water solubility, cell permeability and bioavailability. (chemie.de)
  • Coumarin containing poly(ethylene glycol) monols and diols were prepared in a telechelic fashion using quantitative end group esterification. (elsevier.com)
  • The chain extended poly(ethylene glycol)s were subsequently converted to their original molecular weight via the photocleavage reaction of the coumarin dimer at 254 nm with less than 2 J·cm -2 . (elsevier.com)
  • Love, Brian J. / Photoreversible chain extension of poly(ethylene glycol) . (elsevier.com)
  • Linear-dendritic ABA triblock copolymers containing poly(ethylene glycol) (PEG) as B block and hyperbranched poly(citric acid) (PCA) as A blocks were synthesized through polycondensation. (fu-berlin.de)
  • From the clinical editor: This manuscript investigates the potentials of linear-dendritic ABA triblock copolymers containing poly(ethylene glycol) (PEG) as B block and hyperbranched poly(citric acid) (PCA) as A blocks for future applications in nanomedicine. (fu-berlin.de)
  • Spencer, Nicholas D. / Poly(L-lysine)-graft-Poly(ethylene glycol) (PLL-g-PEG): A universal aqueous lubricant additive for tribosystem involving thermoplastics . (dtu.dk)
  • Lee, S & Spencer, ND 2008, ' Poly(L-lysine)-graft-Poly(ethylene glycol) (PLL-g-PEG): A universal aqueous lubricant additive for tribosystem involving thermoplastics ', Lubrication Science , vol. 20, no. 1, pp. 21-34. (dtu.dk)
  • However, no study has compared effect of poly ethylene glycol (PEG) and lactulose on occult constipation. (scielo.org.pe)
  • Polyethylene glycols (PEGs) are products made of condensed ethylene oxide and water that can contain various derivatives and have various functions. (drugbank.com)
  • Here we compare the current blockade events caused by flexible linear polymers of ethylene glycol (PEGs) and structurally well-defined tungsten polyoxymetallate nanoparticles in the nanopores formed by Staphylococcus aureus α -hemolysin and Aeromonas hydrophila aerolysin. (nanion.de)
  • A biodegradable poly(ethylene glycol) (PEG)-poly(beta-amino ester) (PBAE)-PEG triblock copolymer was developed that is useful for drug delivery. (elsevier.com)
  • The preparation and characterization of a novel linear D,L-octapeptide-poly(ethylene glycol) conjugate, formulated as biocompatible nanocarrier of hydrophobic drugs, was reported. (elsevier.com)
  • Polyethylene glycol (PEG) is a long chain of ethylene glycol molecules that results in an extremely large molecule. (medscape.com)
  • Polyethylene naphthalate or PEN is a polyester included among naphthalate-2, ethylene glycol and 6-dicarboxylic acid. (historic-kirkwood.com)
  • The test cultures were incubated overnight before being rinsed with PBS and then fixed with 300 uM m-maleimidobenzoyl-N-hydroxysuccinimidyl ester (MBS) in microtubule stabilizing buffer (MTSB) composed of 4% (w/v) polyethylene glycol (PEG) 8000, 100 mM 1,4-piperazinediethanesulfonic acid (PIPES),10 mM ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid (EGTA), pH 6.9 for at least 16h at RT. (cellimagelibrary.org)
  • Pore size of the intercrystalline pathways of MFI zeolite membranes was controlled by adding poly ethylene glycol (PEG) as a polymeric template. (elsevier.com)
  • Synonyms: 1,2-Epoxyethane is used in the manufacture of mono-ethylene glycol. (who.int)
  • Hydroxypropyl-guar (HPG) is used along with polyethylene glycol 400 (PEG) and propylene glycol (PG) as a gelling agent that conforms to abnormalities of the tear film and existing irregularities on the ocular surface 16 . (drugbank.com)
  • PEG provides lubrication and acts as a surfactant by coating the eye and interacting with propylene glycol and other solutions that help to act as surfactants on the eye mucosa 15 . (drugbank.com)
  • The capsule is printed with black pharmaceutical ink which contains following ingredients: black iron oxide, potassium hydroxide, propylene glycol and shellac. (hipaaspace.com)
  • It does not contain propylene glycol, polyethylene glycol, or vegetable glycerin. (treeoflifecannabis.ca)
  • Solubility prediction of paracetamol in water-ethanol-propylene glycol mixtures at 25 and 30 degrees C using practical approaches. (openrepository.com)
  • Solubility prediction of salicylic acid in water-ethanol-propylene glycol mixtures using the Jouyban-Acree model. (openrepository.com)
  • Polyethylene glycol 3350 is used to treat occasional constipation. (medlineplus.gov)
  • Polyethylene glycol 3350 is in a class of medications called osmotic laxatives. (medlineplus.gov)
  • Polyethylene glycol 3350 comes as a powder to be mixed with a liquid and taken by mouth. (medlineplus.gov)
  • Take polyethylene glycol 3350 exactly as directed. (medlineplus.gov)
  • Polyethylene glycol 3350 may be habit-forming. (medlineplus.gov)
  • It may take 2 to 4 days for polyethylene glycol 3350 to produce a bowel movement. (medlineplus.gov)
  • If you are using polyethylene glycol 3350 from a bottle, use the measuring line on the bottle cap to measure a single dose (about 1 heaping tablespoon). (medlineplus.gov)
  • If you are using polyethylene glycol 3350 packets, each packet contains a single dose. (medlineplus.gov)
  • If you become pregnant while taking polyethylene glycol 3350, call your doctor. (medlineplus.gov)
  • Polyethylene glycol 3350 may cause side effects. (medlineplus.gov)
  • Polyethylene Glycol 3350 NF, 17 grams, or placebo for 14 days. (nih.gov)
  • Polyethylene Glycol 3350 NF or placebo for 10 days each. (nih.gov)
  • Polyethylene Glycol 3350 NF may result in electrolyte imbalance and dependence on laxatives. (nih.gov)
  • Polyethylene Glycol 3350 in the Treatment of Chronic Idiopathic Constipation: Post hoc Analysis Using FDA Endpoints. (harvard.edu)
  • Do not use it if you had an allergic reaction to methoxy polyethylene glycol-epoetin beta. (stlukes-stl.com)
  • Methoxy polyethylene glycol-epoetinbeta [MART. (nih.gov)
  • Dr said to take colace, miralax, (polyethylene glycol) or milk of magnesia for constipation. (healthtap.com)
  • Is miralax (polyethylene glycol) safe to use on a one year d for constipation? (healthtap.com)
  • Am 17 weeks pregnant having severe constipation, is miralax (polyethylene glycol) safe to use during pregnancy? (healthtap.com)
  • Polyethylene glycol is an osmotic stool softener used for treatment of occasional constipation. (medscape.com)
  • Comparison of the effectiveness of polyethylene glycol with and without electrolytes in constipation: a systematic review and network meta-analysis. (bvsalud.org)
  • I've become focused on polyethylene glycol 1000, mentioned positively by many for stabilization wood for turning projects. (woodweb.com)
  • In this research, a novel biodegradable D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) (TPGS-b-(PCL-ran-PGA)) nanoparticle (NP) was prepared as a delivery system for small interfering ribonucleic acid (siRNA) molecules targeting HIF-1α in nasopharyngeal carcinoma gene therapy. (dovepress.com)
  • D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) is accredited as a protected pharmaceutical adjuvant with marked antioxidant and anti inflammatory actions. (vlaamseverpleegunie.be)
  • Poly Tetra Methylene Ether Glycol 1800 exports have increased since Q4 of 2021, and Poly Tetra Methylene Ether Glycol 2000 and Poly Tetra Methylene Ether Glycol 1000 exports with higher unit prices have also increased. (chemanalyst.com)
  • Article written by Cal R. Fremling and Donald L. Hemming regarding the use of polyethylene glycol 1000 (here, Carbowax 1000) to preserve small fish, reptiles, and amphibians. (winona.edu)
  • Water, Glycerin, Ethanol, Acacia, Vitamin E (as d-alpha tocopheryl polyethylene glycol 1000 succinate and as natural mixed tocopherols. (myersdetox.com)
  • Consisting of a broad portfolio of polyethylene glycols (PEGs), BASF's portfolio of ethoxylated polymer-solubilizers is known for its versatility across a myriad of dosage forms. (basf.com)
  • Polyethylene glycols (PEGs) are ethoxylated polymer-solubilizers that are readily soluble in water, ethanol, acetone, glycols and chloroform. (basf.com)
  • Is miralax (polyethylene glycol) safe during pregnancy? (healthtap.com)
  • The dr recommended miralax (polyethylene glycol) but we read mixed info. (healthtap.com)
  • Toddler got constipated and started taking Miralax, (polyethylene glycol) but now if she stops taking it she gets constipated right away. (healthtap.com)
  • One of the vital latest and promising cross-linkers is polyethylene glycol diglycidyl ether (PEGDE), utilized by the corporate Matex Lab S.p.A., (Brindisi, Italy) to create the HA dermal filler PEGDE household. (vlaamseverpleegunie.be)
  • PTMEG (Poly Tetra Methylene Ether Glycol) exports reached new highs of 6,710 tonnes in February 2022, up 224 percent on the year and 12.2 percent on the month, as demand recovered, but supply was insufficient outside China. (chemanalyst.com)
  • Since Q4 2021, Poly Tetra Methylene Ether Glycol exports have steadily increased, eventually surpassing imports. (chemanalyst.com)
  • Second, following the Lunar New Year holiday, the price of Poly Tetra Methylene Ether Glycol surged globally as crude oil and natural gas prices rose, especially after March. (chemanalyst.com)
  • The price of Poly Tetra Methylene Ether Glycol has continued to climb in the worldwide market, but the price of Poly Tetra Methylene Ether Glycol in China has decreased, owing to stable costs and dropping demand as the Lunar New Year approaches. (chemanalyst.com)
  • As a result, shipments of Poly Tetra Methylene Ether Glycol from China enjoyed a significant price advantage. (chemanalyst.com)
  • In March, the price of Poly Tetra Methylene Ether Glycol for downstream spandex increased somewhat. (chemanalyst.com)
  • This suggests that demand for Poly Tetra Methylene Ether Glycol will be strong, but downstream purchasers have shown a lack of interest in high-priced Poly Tetra Methylene Ether Glycol. (chemanalyst.com)
  • Since Q4 of 2021, the average export price of Poly Tetra Methylene Ether Glycol has been above USD 6.2-6.6/kg, owing to a shift in export structure. (chemanalyst.com)
  • As per ChemAnalyst, "Poly Tetra Methylene Ether Glycol exports are projected to continue high in Q2 2022, as the price of the commodity in the global market is expected to be high in the short term due to high costs, and domestic Poly Tetra Methylene Ether Glycol facilities will focus more on export after local capacity expanded in China. (chemanalyst.com)
  • Ceteareth-33 is a polyethylene glycol ether of Cetearyl Alcohol (q.v. (ewg.org)
  • The polyethylene glycols are currently considered an essential class of polymers with several applications in industry, medicine, and biology. (growkudos.com)
  • Assess side effects between lactulose and Polyethylene Glycol. (who.int)
  • Assess tolerance between lactulose and Polyethylene Glycol. (who.int)
  • Establish colonoscopy global adenoma detection rate with lactulose and Polyethylene Glycol. (who.int)
  • Establish colonoscopy cecal intubation rate in with lactulose and Polyethylene Glycol. (who.int)
  • Polyethylene glycol (PEG) has low toxicity and is used in a variety of products (creams, laxatives, lubricants). (sielc.com)
  • The panel agreed on 9 recommendations for the management of patients with IBS-C. The panel made a strong recommendation for linaclotide (high certainty) and conditional recommendations for tenapanor, plecanatide, tegaserod, and lubiprostone (moderate certainty), polyethylene glycol laxatives, tricyclic antidepressants, and antispasmodics (low certainty). (bvsalud.org)
  • Solubility of pioglitazone hydrochloride in ethanol, N-methyl pyrrolidone, polyethylene glycols and water mixtures at 298.20 °K. (openrepository.com)
  • tell your doctor and pharmacist if you are allergic to polyethylene glycol or any other medications. (medlineplus.gov)
  • obstruction and patients known to be allergic to polyethylene glycol. (nih.gov)
  • Since the IARC review, three new occupational biomonitoring studies have been conducted: one in a chemical plant manufacturing glycols and glycol ethers from PO and two in PO producing plants. (who.int)
  • A laxative effect is generated because polyethylene glycol is not absorbed and continues to hold water by osmotic action through the small bowel and colon, resulting in mechanical cleansing. (medscape.com)
  • In theory, there is less risk of dehydration or electrolyte imbalance with isotonic polyethylene glycol than with hypertonic sugar solutions. (medscape.com)
  • Promising hydrogels are hyaluronic acid, alginate or agarose as well as synthetic hydrogels based on Polyethylene glycol, Polyvinyl alcohol (PVA) or Polyacrylate. (anton-paar.com)
  • HILIC separation of polyethylene glycol can be used to determine polyethylene glycol content in various formulations using ELSD, RI detection, or LC/MS detection. (sielc.com)
  • This shampoo is free of parabens (which can disrupt the reproductive system), sodium lauryl (an irritant and pollutant), phthalate (a possible carcinogen and hormone disrupter), and butylene glycol (a preservative). (healthytippingpoint.com)
  • Polyethylene glycol is a synthetic chemical that is made in chemical plants. (helenatur.com)
  • The Castrol PG185 high-performance synthetic gas compressor oil is based on poly-alkylene glycol and can be used to lubricate compressors dealing with hydrocarbon and chemical gases. (castrol.com)
  • When attached to various protein medications, polyethylene glycol allows a slowed clearance of the carried protein from the blood. (sielc.com)
  • Polyethylene glycol 400 is an ingredient used in a wide variety of medications, and is not an approved medication. (drugbank.com)
  • Polyethylene glycol 400 (PEG 400) is a low-molecular-weight grade of polyethylene glycol with a low-level toxicity. (drugbank.com)
  • Polyethylene glycol, when free in solution, may also demonstrate attraction to the surfaces of various types of vesicles, cells or macromolecules, leading to polymer adsorption and subsequently either a repulsion or to an attraction, via bridging, of the surfaces or vesicles-again strongly depending on the temperature, molecular weight, and concentration of the polyethylene glycol. (drugbank.com)
  • Low molecular weight polyethylene glycol (such as PEG-400) generally promotes cells or vesicles to adhere (depletion attraction), high molecular weight polyethylene glycol causes them to repel 18 . (drugbank.com)
  • abstract = "Goal: The goal of this study was to estimate the risk of renal injury after the use of 3-L polyethylene glycol (PEG) before outpatient colonoscopy. (elsevier.com)
  • Polyethylene glycol is supplied with a measuring cap marked to contain 17 g of laxative powder when filled to the indicated line. (medscape.com)
  • Butyl poly glycol (also known as BPGL) is a brown liquid with a pungent odour. (solventis.net)
  • 1-Propanol or soap and water were more effective in removing pesticides from skin than polyethylene glycol or D-TAM, but the amount of pesticide recovered from skin was affected by the chemical characteristics of the pesticide (such as water solubility) and the amount of pesticide originally on the skin. (cdc.gov)
  • For untreated wastewater, 1 L was centrifuged for 15 min at 9,000 × g and concentrated with polyethylene glycol (resuspended in 4 mL distilled water). (cdc.gov)
  • For treated wastewater and river water, 1 L was directly concentrated with polyethylene glycol. (cdc.gov)
  • Many cosmetics products are based on Polyethylene glycol. (helenatur.com)