AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Polycythemia VeraPolycythemiaThrombocythemia, EssentialJanus Kinase 2Primary MyelofibrosisMyeloproliferative DisordersPipobromanThrombocytosisErythroid Precursor CellsAloeErythropoietinPhlebotomyReceptors, ThrombopoietinErythropoiesisGranulocytesReceptors, ErythropoietinThrombosisHydroxyureaBloodlettingHematocritMutation, MissenseHematopoiesis, ExtramedullaryErythroid CellsMutationAmino Acid SubstitutionGPI-Linked ProteinsPlatelet CountMegakaryocytesColony-Forming Units AssayBudd-Chiari SyndromeIsoantigensLeukemia, Myeloid, Chronic, Atypical, BCR-ABL NegativeChromosomes, Human, 19-20ThrombopoietinBone MarrowHomozygoteHematopoietic Stem CellsSplenomegaly
Polycythemia Vera
A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
Polycythemia
An increase in the total red cell mass of the blood. (Dorland, 27th ed)
Thrombocythemia, Essential
A clinical syndrome characterized by repeated spontaneous hemorrhages and a remarkable increase in the number of circulating platelets.
Janus Kinase 2
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
Primary Myelofibrosis
A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
Myeloproliferative Disorders
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
Pipobroman
An antineoplastic agent that acts by alkylation.
Thrombocytosis
Increased numbers of platelets in the peripheral blood. (Dorland, 27th ed)
Erythroid Precursor Cells
The cells in the erythroid series derived from MYELOID PROGENITOR CELLS or from the bi-potential MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS which eventually give rise to mature RED BLOOD CELLS. The erythroid progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E); BFU-E differentiate into CFU-E on stimulation by ERYTHROPOIETIN, and then further differentiate into ERYTHROBLASTS when stimulated by other factors.
Aloe
A plant genus of the family Aloeaceae, order Liliales (or Asphodelaceae, Asparagales in APG system) which is used medicinally. It contains anthraquinone glycosides such as aloin-emodin or aloe-emodin (EMODIN).
Erythropoietin
Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.
Phlebotomy
The techniques used to draw blood from a vein for diagnostic purposes or for treatment of certain blood disorders such as erythrocytosis, hemochromatosis, polycythemia vera, and porphyria cutanea tarda.
Receptors, Thrombopoietin
Cell surface receptors that are specific for THROMBOPOIETIN. They signal through interaction with JANUS KINASES such as JANUS KINASE 2.
Erythropoiesis
The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.
Granulocytes
Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.
Receptors, Erythropoietin
Cell surface proteins that bind erythropoietin with high affinity and trigger intracellular changes influencing the behavior of cells.
Thrombosis
Formation and development of a thrombus or blood clot in the blood vessel.
Hydroxyurea
An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Bloodletting
Puncture of a vein to draw blood for therapeutic purposes. Bloodletting therapy has been used in Talmudic and Indian medicine since the medieval time, and was still practiced widely in the 18th and 19th centuries. Its modern counterpart is PHLEBOTOMY.
Hematocrit
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
Mutation, Missense
A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)
Hematopoiesis, Extramedullary
The formation and development of blood cells outside the BONE MARROW, as in the SPLEEN; LIVER; or LYMPH NODES.
Erythroid Cells
The series of cells in the red blood cell lineage at various stages of differentiation.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Amino Acid Substitution
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
GPI-Linked Proteins
A subclass of lipid-linked proteins that contain a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE which holds them to the CELL MEMBRANE.
Platelet Count
The number of PLATELETS per unit volume in a sample of venous BLOOD.
Megakaryocytes
Very large BONE MARROW CELLS which release mature BLOOD PLATELETS.
Colony-Forming Units Assay
A cytologic technique for measuring the functional capacity of stem cells by assaying their activity.
Budd-Chiari Syndrome
A condition in which the hepatic venous outflow is obstructed anywhere from the small HEPATIC VEINS to the junction of the INFERIOR VENA CAVA and the RIGHT ATRIUM. Usually the blockage is extrahepatic and caused by blood clots (THROMBUS) or fibrous webs. Parenchymal FIBROSIS is uncommon.
Isoantigens
Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
A myelodysplastic/myeloproliferative disorder characterized by myelodysplasia associated with bone marrow and peripheral blood patterns similar to CHRONIC MYELOID LEUKEMIA, but cytogenetically lacking a PHILADELPHIA CHROMOSOME or bcr/abl fusion gene (GENES, ABL).
Chromosomes, Human, 19-20
The short, metacentric human chromosomes, called group F in the human chromosome classification. This group consists of chromosome pairs 19 and 20.
Thrombopoietin
A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow MEGAKARYOCYTES and their release of blood platelets. The process is called THROMBOPOIESIS.
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Homozygote
An individual in which both alleles at a given locus are identical.
Hematopoietic Stem Cells
Progenitor cells from which all blood cells derive.
Splenomegaly
Enlargement of the spleen.

Effect of obesity on red cell mass results. (1/454)

Measurement of red cell mass with isotope dilution remains an important diagnostic test in the evaluation of patients with suspected polycythemia vera (PCV). Results and reference ranges are typically expressed in units normalized for body weight (mL/kg). Obesity is common in polycythemic patients, and it is important to know how the various published normative ranges compare across a wide range of body weights. METHODS: We retrospectively reviewed 51 consecutive patients referred for red cell mass determination with 51Cr red blood cell dilution. Results were expressed in milliliters per kilogram (mL/kg) by using the actual patient weight and after adiposity adjustments using ideal body weight, body mass index (BMI) and combinations of height-weight, including body surface area. Results were classified as normal, elevated or PCV. RESULTS: There was a high prevalence of obesity in our population (28/51 [55%] with BMI > 27 kg/m2, BMI range 16.0-54.8 kg/m2). The method used to compensate for obesity had a dramatic effect on the derived red cell mass, the fraction of patients with elevated measurements and the fraction of patients meeting criteria for PCV. Concordance for categorization as normal, elevated or PCV by all methods was only 47.1%. CONCLUSION: Obesity is a common confounding factor in the interpretation of red cell mass measurements. Currently published reference ranges generate inconsistent results when extrapolated to obese patients. Further normative data on obese subjects are needed to determine which method (if any) is optimal.  (+info)

Posttranslational processing of the thrombopoietin receptor is impaired in polycythemia vera. (2/454)

Recently, we demonstrated a marked reduction in the expression of the thrombopoietin receptor, Mpl, in polycythemia vera (PV) platelets and megakaryocytes using an antiserum against the Mpl extracellular domain. To further examine this abnormality, we raised an antibody to the Mpl C-terminus. Immunologic analysis of PV platelets with this antiserum confirmed the reduction in Mpl expression. However, the C-terminal antiserum detected 2 forms of Mpl in PV platelets in contrast to normal platelets, in which a single form of Mpl was detected by both the extracellular domain and C-terminal antisera. Two-dimensional gel electrophoresis studies with isoelectric focusing in the first dimension identified normal platelet Mpl as an 85 to 92 kD protein with an isoelectric point (pI) of 5.5. PV platelets contained an additional 80 to 82 kD Mpl Mpl isoform with a pI of 6.5. Analysis of Mpl expressed by the human megakaryocytic cell line, Dami, showed 2 isoforms similar to those found in PV platelets suggesting a precursor-product relationship. Digestion of Dami cell and normal platelet lysates with neuraminidase converted the more acidic Mpl isoform to the more basic one, indicating that the 2 isoforms differed with respect to posttranslational glycosylation. Furthermore, in contrast to normal platelet Mpl, PV platelet Mpl was susceptible to endoglycosidase H digestion, indicating defective Mpl processing by PV megakaryocytes. The glycosylation defect was specific for Mpl, as 2 other platelet membrane glycoproteins, glycoprotein IIb and multimerin, were processed normally. Importantly, the extent of the PV platelet Mpl glycosylation defect correlated with disease duration and extramedullary hematopoiesis.  (+info)

Nonrandom chromosomal abnormalities in hematologic disorders of man. (3/454)

A nonrandom pattern of chromosomal abnormalities occurs in bone marrow cells obtained from patients with hematologic disorders who have an abnormal karyotype involving a C group chromosome. An additional number 8 chromosome is the most common abnormality, found in more than one-half of the patients studies. An additional number 9 chromosome and the loss of all or part of a number 7 are abnormalities that occur more often than might be expected by chance. It is proposed that specific human chromosomal abnormalities may be related to different specific etiologic agents.  (+info)

Electron microscopic x-ray microanalysis of normal and leukemic human lymphocytes. (4/454)

A comparative study of the elemental content of normal and leukemic cells was undertaken on a few subjects, using electron microscopic x-ray microanalysis. Phosphorus, sulfur, chlorine, calcium, copper, and zinc were detected in intracellular loci. The concentration of some of the above elements appeared to be disease related. In leukemic lymphocytes, the nuclear zinc was significantly lower than that recorded in normal lymphocytes, while the phosphorus was only moderately decreased. This suggests a faulty zinc uptake or binding in leukemic cells. The possible consequences of intracellular zinc deficiency are discussed.  (+info)

Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera. (5/454)

Polycythemia vera (PV) is a clonal stem cell disorder characterized by hyperproliferation of the erythroid, myeloid, and megakaryocytic lineages. Although it has been shown that progenitor cells of patients with PV are hypersensitive to several growth factors, the molecular pathogenesis of this disease remains unknown. To investigate the molecular defects underlying PV, we used subtractive hybridization to isolate complementary DNAs (cDNAs) differentially expressed in patients with PV versus normal controls. We isolated a novel gene, subsequently named PRV-1, which is highly expressed in granulocytes from patients with PV (n = 19), but not detectable in normal control granulocytes (n = 21). Moreover, PRV-1 is not expressed in mononuclear cells from patients with chronic myelogenous leukemia (n = 4) or acute myelogenous leukemia (n = 5) or in granulocytes from patients with essential thrombocythemia (n = 4) or secondary erythrocytosis (n = 4). Northern blot analysis showed that PRV-1 is highly expressed in normal human bone marrow and to a much lesser degree in fetal liver. It is not expressed in a variety of other tissues tested. Although PRV-1 is not expressed in resting granulocytes from normal controls, stimulation of these cells with granulocyte colony-stimulating factor induces PRV-1 expression. The PRV-1 cDNA encodes an open reading frame of 437 amino acids, which contains a signal peptide at the N-terminus and a hydrophobic segment at the C-terminus. In addition, PRV-1 contains 2 cysteine-rich domains homologous to those found in the uPAR/Ly6/CD59/snake toxin-receptor superfamily. We therefore propose that PRV-1 represents a novel hematopoietic receptor. (Blood. 2000;95:2569-2576)  (+info)

Acute myelogenous leukaemia and myelomonocytic blast crisis following polycythemia vera in HIV positive patients: report of cases and review of the literature. (6/454)

BACKGROUND: Acute myelogenous leukaemia (AML) and myeloproliferative diseases are rare in HIV-infected individuals and optimal treatment has not been defined. PATIENTS AND METHODS: We report on the cases of two HIV-infected men, one with AML and one with myeloid blast crisis after polycythaemia vera (PV). A comprehensive review of the available literature will be presented. RESULTS: Patient 1, a 57-year-old bisexual man known to be HIV seropositive for more than four years (CDC-category A1), presented with a pulmonary infiltrate. On admission WBC showed leukocytes 5.6 x 10(9)/l and the differential revealed 80% blasts. A diagnosis of AML FAB M0 was made. Pneumonia resolved under antibiotic treatment and the patient received induction chemotherapy. However, he once more developed multiple pulmonary infiltrates and died of respiratory failure despite broad spectrum antibiotic and antimycotic therapy. Autopsy revealed pulmonary aspergillosis. Patient 2 was a 63-year old HIV-positive hemophiliac (CDC A3) with a 10-year history of PV. On admission his white cell count showed leukocytes 256.6 x 10(9)/l with 82% blasts. Cytochemistry revealed myelomonocytic differentiation. The patient died of tumor lysis syndrome with renal and cardio-pulmonary failure two days later. CONCLUSIONS: This is the first report of an HIV-infected individual with AML M0. The literature describes the cases of 39 HIV+ patients with AML and only one further case with PV. The association of both, myeloproliferative disease and AML with HIV infection is coincidental. However, the proportion of FAB type M4/5 appears to be higher than in the general population. Despite a high risk of treatment associated mortality durable remissions can be achieved in a small proportion of HIV-infected patients with AML.  (+info)

Tumor-like splenic extramedullary hematopoiesis in a patient with myelofibrosis. (7/454)

A 61-year-old woman, who was diagnosed in 1982 as having polycythemia vera, was admitted to our hospital in July 1998 because of a splenic tumor in an enlarged spleen due to myelofibrosis. As it was difficult to identify the etiology of the splenic tumor, partial splenectomy was carried out. The resected tumor proved to be an extremely proliferative lesion as the result of extramedullary hematopoiesis. Since it is difficult to diagnose the etiology of splenic tumor, the collection and analysis of reports of relevant cases may well facilitate diagnosis.  (+info)

Towards a molecular understanding of polycythemia rubra vera. (8/454)

Polycythemia rubra vera (PV) is one of four diseases collectively called the myeloproliferative disorders (MPDs). Each disorder leads to an increased production of one or several hematopoietic cell lineages. MPDs arise from acquired mutations in a pluripotent hematopoietic stem cell. However, the molecular mechanisms leading to the development of these diseases are poorly understood. This review will summarize and evaluate recent advances in our understanding of one particular MPD, PV.  (+info)

Polycythaemia Rubra Vera. PRV information and treatment | PatientPolycythaemia Rubra Vera. PRV information and treatment | Patient
Polycythaemia Rubra Vera (PRV) is known as polycythaemia vera, plethora vera, primary polycythaemia, Osler-Vaquez disease. Polycythaemia rubra vera (PRV) common form.
https://patient.info/doctor/polycythaemia-vera-pro
Polycythemia Vera Pipeline Assessment, Key Companies And Emerging Drugs - Latest News FinancePolycythemia Vera Pipeline Assessment, Key Companies And Emerging Drugs - Latest News Finance
Report Highlights. A better understanding of disease pathogenesis contributing to the development of novel therapeutics for Polycythemia Vera. In the coming years, the Polycythemia Vera market is set to change due to the rising awareness of the disease, and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market. The companies and academics that are working to assess challenges and seek opportunities that could influence Polycythemia Vera R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition.. A detailed portfolio of major pharma players who are involved in fueling the Polycythemia Vera treatment market. Several potential therapies for Polycythemia Vera are under investigation. With the expected launch of these emerging therapies, it is expected that there will be a significant impact on the Polycythemia Vera market size in the coming years. ...
http://news.latestnewsfinance.com/story/261331/polycythemia-vera-pipeline-assessment-key-companies-and-emerging-drugs.html
Polycythemia vera: A case report and discussion on pathogenic mechanisms of increased thrombosis<...
TY - JOUR. T1 - Polycythemia vera. T2 - A case report and discussion on pathogenic mechanisms of increased thrombosis. AU - Gumina, Richard J.. AU - Foley, David A.. AU - Tefferi, Ayalew. AU - Rooke, Thom W.. AU - Shields, Raymond C.. PY - 2002. Y1 - 2002. N2 - Polycythemia vera is a myeloproliferative disorder characterized by increased red cell mass and frequently complicated by venous and arterial thrombosis. The mechanism underlying the increased incidence of thrombotic events remains illusive. Presented in this report are a case of a 77-year-old man diagnosed with polycythemia vera and a review of the current literature on the mechanisms underlying the increased incidence of thrombotic events in polycythemia vera.. AB - Polycythemia vera is a myeloproliferative disorder characterized by increased red cell mass and frequently complicated by venous and arterial thrombosis. The mechanism underlying the increased incidence of thrombotic events remains illusive. Presented in this report are a ...
https://experts.nebraska.edu/en/publications/polycythemia-vera-a-case-report-and-discussion-on-pathogenic-mech
Polycythemia rubra vera definition | Drugs.comPolycythemia rubra vera definition | Drugs.com
Definition of polycythemia rubra vera. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
https://www.drugs.com/dict/polycythemia-rubra-vera.html
Symptom Severity and Clinical Variables of Polycythemia Vera Patients with Splenomegaly, Phlebotomy Requirements and/or...Symptom Severity and Clinical Variables of Polycythemia Vera Patients with Splenomegaly, Phlebotomy Requirements and/or...
Symptom Severity and Clinical Variables of Polycythemia Vera Patients with Splenomegaly, Phlebotomy Requirements and/or Hydroxyurea Use: a Retrospective Evaluation of 1334 Patients ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:799160
JAK2 Exon 12-15 Sequencing, Polycythemia Vera Reflex - Wyoming Medical Center
The Janus kinase 2 gene (JAK2) codes for a tyrosine kinase (JAK2) that is associated with the cytoplasmic portion of a variety of transmembrane cytokine and growth factor receptors important for signal transduction in hematopoietic cells. Signaling via JAK2 activation causes phosphorylation of downstream signal transducers and activators of transcription (STAT) proteins (eg, STAT5) ultimately leading to cell growth and differentiation. The JAK2 V617F is located in exon 14 and present in 50% to 60% of primary myelofibrosis and essential thrombocythemia, and 95% to 98% of polycythemia vera (PV). In the rest of the polycythemia vera cases, over 50 different mutations have been reported within exons 12 through 15 of JAK2 and essentially all of the non-V617F JAK2 mutations have been identified in polycythemia vera. These mutations include point mutations and small insertions or deletions. Several of the exon 12 mutations have been shown to have biologic effects similar to those caused by the V617F ...
http://wyomingmedicalcenter.testcatalog.org/show/JAKXR
Endothelial nitric oxide synthase gene t-786c polymorphism among polycythaemia vera patients in khartoum, 2016 | International...Endothelial nitric oxide synthase gene t-786c polymorphism among polycythaemia vera patients in khartoum, 2016 | International...
Background: A single nucleotide polymorphism (T , C) rs2070744 due to transition of a thymine to a cytosine at T-786C in the promoter region of eNOS was found to reduce the rate of mRNA transcription by 50%, resulting in decreased serum NO levels which can inhibit apoptosis or stimulate tumor proliferation, angiogenesis and metastasis. Objective: To evaluate the association between Nitric Oxide Synthase gene T-786C polymorphism and Polycythemia Vera patients in Sudan. Material and Methods: A total of 40 patients with Polycythemia Vera and 50 control subjects were enrolled this study. DAN extrication samples previously extracted from EDTA Blood collected from SPV and store at- 20C. Analysis of the eNOS¬786T , C promoter polymorphism were carried out by allele ¬specific polymerase chain reaction method (PCR). Results: The present study reported that, molecular analysis showed that, the most frequent genotype in patients was TT 65% (26) followed by TC genotype 25% (10) and the reaming frequency ...
http://ijirr.com/endothelial-nitric-oxide-synthase-gene-t-786c-polymorphism-among-polycythaemia-vera-patients
Current management of polycythemia vera<...
TY - JOUR. T1 - Current management of polycythemia vera. AU - Tefferi, Ayalew. PY - 2002. Y1 - 2002. N2 - Over a century has elapsed since the first description of polycythemia vera (PV), and current treatment recommendations are primarily based on the results of clinical trials that were performed in the late 1960s and early 1970s. Continued identification and appropriate utilization of PV-specific biologic parameters may allow substantial modification of early diagnostic criteria. New cytoreductive treatment agents are increasingly being used without any evidence of superiority over conventional therapy. The role of aspirin is being readdressed by an ongoing controlled study. Transformation of PV into either myelofibrosis with myeloid metaplasia or acute leukemia remains a major complication that may not be influenced by current therapy.. AB - Over a century has elapsed since the first description of polycythemia vera (PV), and current treatment recommendations are primarily based on the ...
https://mayoclinic.pure.elsevier.com/en/publications/current-management-of-polycythemia-vera
Polycythemia - WikipediaPolycythemia - Wikipedia
Primary polycythemias are due to factors intrinsic to red cell precursors. Polycythemia vera (PCV), polycythemia rubra vera (PRV), or erythremia, occurs when excess red blood cells are produced as a result of an abnormality of the bone marrow.[3] Often, excess white blood cells and platelets are also produced. PCV is classified as a myeloproliferative disease. Symptoms include headaches and vertigo, and signs on physical examination include an abnormally enlarged spleen and/or liver. In some cases, affected individuals may have associated conditions including high blood pressure or formation of blood clots. Transformation to acute leukemia is rare. Phlebotomy is the mainstay of treatment. A hallmark of polycythemia is an elevated hematocrit, with Hct , 55% seen in 83% of cases.[4] A somatic (non-hereditary) mutation (V617F) in the JAK2 gene is found in 95% of cases, though also present in other myeloproliferative disorders.[5] Primary familial polycythemia, also known as primary familial and ...
https://en.wikipedia.org/wiki/Polycythemia
Polycythemia - WikipediaPolycythemia - Wikipedia
Primary polycythemias are due to factors intrinsic to red cell precursors. Polycythemia vera (PCV), polycythemia rubra vera (PRV), or erythremia, occurs when excess red blood cells are produced as a result of an abnormality of the bone marrow.[3] Often, excess white blood cells and platelets are also produced. PCV is classified as a myeloproliferative disease. Symptoms include headaches and vertigo, and signs on physical examination include an abnormally enlarged spleen and/or liver. In some cases, affected individuals may have associated conditions including high blood pressure or formation of blood clots. Transformation to acute leukemia is rare. Phlebotomy is the mainstay of treatment. A hallmark of polycythemia is an elevated hematocrit, with Hct , 55% seen in 83% of cases.[4] A somatic (non-hereditary) mutation (V617F) in the JAK2 gene is found in 95% of cases, though also present in other myeloproliferative disorders.[5]. Primary familial polycythemia, also known as primary familial and ...
https://en.m.wikipedia.org/wiki/Erythrocytosis
Polycythemia vera | Multimedia Encyclopedia | Health Information | St. Lukes HospitalPolycythemia vera | Multimedia Encyclopedia | Health Information | St. Lukes Hospital
Kremyanskaya M, Najfeld V, Mascarenhas J, Hoffman R. The polycythemias. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi J, eds. Hematology: Basic Principles and Practice . 6th ed. Philadelphia, PA: Elsevier Saunders; 2013:chap 67. National Cancer Institute: PDQ Chronic Myeloproliferative Neoplasms Treatment: Polycythemia Vera. Bethesda, MD: National Cancer Institute. Date last modified December 3, 2014. Available at: www.cancer.gov/cancertopics/pdq/treatment/myeloproliferative/HealthProfessional/page3. Accessed March 3, 2015.. Tefferi A. Polycythemia vera, essential thrombocythemia, and primary myelofibrosis. In: Goldman L, Schafer AI, eds. Goldmans Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 166. ...
https://www.stlukes-stl.com/health-content/health-ency-multimedia/1/000589.htm
A phase II study of vorinostat (MK-0683) in patients with polycythaemia vera and essential thrombocythaemiaA phase II study of vorinostat (MK-0683) in patients with polycythaemia vera and essential thrombocythaemia
Inhibition of histone deacetylases may be an important target in patients with myeloproliferative neoplasms. This investigator-initiated, non-randomized, open-label phase II multi-centre study included 63 patients (19 essential thrombocythaemia, 44 polycythaemia vera) from 15 centres. The primary objective was to evaluate if vorinostat was followed by a decline in clonal myeloproliferation as defined by European Leukaemia Net. Thirty patients (48%) completed the intervention period (24 weeks of therapy). An intention-to-treat response rate of 35% was identified. Pruritus was resolved [19% to 0% (P=0.06)] and the prevalence of splenomegaly was lowered from 50% to 27% (P=0.03). Sixty-five per cent of the patients experienced a decrease in JAK2 V617F allele burden (P=0.006). Thirty-three patients (52% of patients) discontinued study drug before end of intervention due to adverse events (28 patients) or lack of response (5 patients). In conclusion, vorinostat showed effectiveness by normalizing ...
http://oru.diva-portal.org/smash/record.jsf?pid=diva2:1082116
Impact of JAK2V617F Mutation Burden on Disease Phenotype in Chinese Patients with JAK2V617F-positive Polycythemia Vera (PV) and...Impact of JAK2V617F Mutation Burden on Disease Phenotype in Chinese Patients with JAK2V617F-positive Polycythemia Vera (PV) and...
Abstract. Most patients with polycythemia vera (PV) and half of essential thrombocythemia (ET) possess an activating JAK2V617F mutation. The objective of this study was to better define the effect of JAK2V617F mutant allele burden on clinical phenotypes in Chinese patients, especially thrombosis. By real-time polymerase chain reaction (RT-PCR), the JAK2V617F mutation burden was detected in 170 JAK2V617F-positive patients, including 54 PV and 116 ET. The results showed that JAK2V617F allele burden was higher in PV than in ET (P, 0.001). Higher percentage of patients had JAK2V617F allele burden over 20% in PV than in ET (68.5% VS 26.7%) (P, 0.001). In PV patients, higher JAK2V617F allele burden was observed in female (P, 0.05) and leukocytosis patients (WBC above 10×109/L) (P, 0.001). Meanwhile, ET patients showed increased JAK2V617F allele burden in the group with higher hemoglobin (HGB above 150g/L) (P, 0.05), leukocytosis (WBC above 10×109/L) (P, 0.001), splenomegaly (P, 0.05) and thrombosis ...
http://www.medsci.org/v13p0085
A phase 2 study of momelotinib, a potent JAK1 and JAK2 inhibitor, in patients with polycythemia vera or essential...
TY - JOUR. T1 - A phase 2 study of momelotinib, a potent JAK1 and JAK2 inhibitor, in patients with polycythemia vera or essential thrombocythemia. AU - Verstovsek, Srdan. AU - Courby, Stephane. AU - Griesshammer, Martin. AU - Mesa, Ruben A.. AU - Brachmann, Carrie Baker. AU - Kawashima, Jun. AU - Maltzman, Julia D.. AU - Shao, Lixin. AU - Xin, Yan. AU - Huang, Daniel. AU - Bajel, Ashish. PY - 2017/9/1. Y1 - 2017/9/1. N2 - Momelotinib is a potent inhibitor of JAK1 and JAK2 that demonstrated efficacy in patients with primary and secondary myelofibrosis. This phase 2, open-label, randomized study evaluated the efficacy and safety of oral once-daily momelotinib (100 mg and 200 mg) for the treatment of polycythemia vera (PV) and essential thrombocythemia (ET). The primary endpoint for PV was overall response rate (ORR), defined as the proportion of patients with hematocrit ,45%, white blood cell count ,10 × 109/L, platelet count ≤400 × 109/L, and resolution of palpable splenomegaly, each lasting ...
https://mayoclinic.pure.elsevier.com/en/publications/a-phase-2-study-of-momelotinib-a-potent-jak1-and-jak2-inhibitor-i
Endothelial dysfunction in patients with polycythaemia veraEndothelial dysfunction in patients with polycythaemia vera
Patients with polycythaemia vera (PV) are at increased risk of developing arterial and venous thromboembolic complications. We investigated whether endothelium-dependent, flow-mediated vasodilatation (FMD) is impaired in PV patients without clinical evidence of artery disease as observed in patients...
https://insights.ovid.com/british-haematology/bjha/2001/11/020/endothelial-dysfunction-patients-polycythaemia/21/00002328
Paraplegia due to a paravertebral extramedullary haemopoiesis in a patient with polycythaemia vera | Journal of Clinical...Paraplegia due to a paravertebral extramedullary haemopoiesis in a patient with polycythaemia vera | Journal of Clinical...
In July 1985, a 43-year-old man was found to have polycythaemia vera. The peripheral blood counts were white cell count 14.15×109/l (neutrophils 80%, lymphocytes 14%, monocytes 5%, eosinophils 1%), haemoglobin concentration 24.8 g/dl, haematocrit 0.7, red cell count 8.15×1012/l (neither anisocytosis nor poikilocytosis nor tear-drop poikilocytosis were observed), platelets 234×109/l. As only the erythroid lineage was affected significantly, he was treated with isovolaemic phlebotomy until April 2004. In May 2004, the patient suddenly developed a spastic paraplegia. Nuclear magnetic resonance imaging showed a posterior extradural tumour extending from T3 to T11 … ...
http://jcp.bmj.com/content/60/5/581
Longer Life Foundation : Functional Dissection of Age-Related Differences in Disease Phenotype in Polycythemia VeraLonger Life Foundation : Functional Dissection of Age-Related Differences in Disease Phenotype in Polycythemia Vera
Lay Summary: Polycythemia vera is a chronic blood cancer that can cause severe complications and early death. Differences in clinical features and outcome have been observed in younger (age ≤ 45) versus older (age ≥ 65) patients with PV. We seek to understand the basis for these differences, and propose a series of genetic and functional studies to address these issues. The long term goal of this work is to leverage the findings from this study to improve longevity for patients with PV.. Full Summary: Polycythemia vera (PV) is a chronic myeloproliferative neoplasm (MPN) that is defined by erythrocytosis and associated with thrombotic complications and a propensity for transformation to myelofibrosis (MF) or secondary acute myeloid leukemia (sAML). Overall survival for patients with PV is substantially impaired compared to age-matched controls. Recent studies have identified age-related differences in disease characteristics and clinical outcome in PV, including distinct JAK2 V617F allele ...
http://www.longerlife.org/research/functional-dissection-of-age-related-differences-in-disease-phenotype-in-polycythemia-vera-229
Jakafi® Helps Maintain Blood Cells Levels in Polycythemia Vera - UNM Comprehensive Cancer CenterJakafi® Helps Maintain Blood Cells Levels in Polycythemia Vera - UNM Comprehensive Cancer Center
CancerConnect News: A new drug called Jakafi® (ruxolitinib) appears to help patients with polycythemia vera (PV) maintain hematocrit control more effectively than best available therapy. These findings were presented at the 56th American Hematology Society Annual Meeting and Exposition, December 6-9, 2014, in San Francisco, California.[1]. Polycythemia vera is a slow-growing type of blood cancer that belongs to a group of blood disorders called myeloproliferative neoplasms (MPN). In these disorders, the bone marrow cells that produce blood cells develop and function abnormally. In PV the bone marrow makes too many blood cells, particularly red blood cells. These excess cells thicken the blood and can cause complications, such as a risk of blood clots or bleeding. Without treatment, PV can be life threatening and can eventually progress to more serious blood cancers, such as myelofibrosis or acute leukemia. Effective treatment, however, can significantly decrease risks and complications.. The ...
http://cancer.unm.edu/2014/12/16/jakafi-helps-maintain-blood-cells-levels-in-polycythemia-vera/
Phase III Trial Finds Jakafi Superior to Standard Therapy for Polycythemia Vera - UNM Comprehensive Cancer CenterPhase III Trial Finds Jakafi Superior to Standard Therapy for Polycythemia Vera - UNM Comprehensive Cancer Center
A Phase III trial finds that Jakafi® (ruxolitinib) is more effective than standard therapy for patients with polycythemia vera (PV). These findings were published in the New England Journal of Medicine.. Polycythemia vera is a slow-growing type of blood cancer that belongs to a group of blood disorders called myeloproliferative neoplasms (MPN). In these disorders, the bone marrow cells that produce blood cells develop and function abnormally. In PV the bone marrow makes too many blood cells, particularly red blood cells. These excess cells thicken the blood and can cause complications, such as a risk of blood clots or bleeding. Without treatment, PV can be life threatening and can eventually progress to more serious blood cancers, such as myelofibrosis or acute leukemia. Effective treatment, however, can significantly decrease risks and complications.. The goal of therapy for PV is to reduce the thickness of the blood and prevent bleeding and clotting. Jakafi has proven effective in the therapy ...
http://cancer.unm.edu/2015/02/17/phase-iii-trial-finds-jakafi-superior-to-standard-therapy-for-polycythemia-vera/
Phase III Trial Finds Jakafi Superior to Standard Therapy for Polycythemia VeraPhase III Trial Finds Jakafi Superior to Standard Therapy for Polycythemia Vera
CancerConnect News: A Phase III trial finds that Jakafi® (ruxolitinib) is more effective than standard therapy for patients with polycythemia vera (PV). These findings were published in the New England Journal of Medicine.. Polycythemia vera is a slow-growing type of blood cancer that belongs to a group of blood disorders called myeloproliferative neoplasms (MPN). In these disorders, the bone marrow cells that produce blood cells develop and function abnormally. In PV the bone marrow makes too many blood cells, particularly red blood cells. These excess cells thicken the blood and can cause complications, such as a risk of blood clots or bleeding. Without treatment, PV can be life threatening and can eventually progress to more serious blood cancers, such as myelofibrosis or acute leukemia. Effective treatment, however, can significantly decrease risks and complications.. The goal of therapy for PV is to reduce the thickness of the blood and prevent bleeding and clotting. Jakafi has proven ...
http://news.cancerconnect.com/phase-iii-trial-finds-jakafi-superior-to-standard-therapy-for-polycythemia-vera/
NewYork-Presbyterian Queens - Polycythemia Vera
Polycythemia vera is one type of myeloproliferative disorder (MPD). Bone marrow contains stem cells that have the ability to mature into adult blood cells that enter the circulation, including red blood cells, white blood cells, and platelets. These stem cells are referred to as pluripotent hematopoeitic precursor cells, or PHPC, due to their versatility. Each PHPC can reproduce itself (clone), in addition to producing daughter cells, called blasts.. In MPD, one abnormal PHPC clone has an ability to overgrow and self-renew more effectively then normal PHPC clones. In polycythemia vera, there may be an increase in just the red blood cells, both the red and white blood cells, or in the red and white blood cells and platelets.. The abnormal PHPC clone is the result of mutations to genes in these cells. These mutations are not inherited, but happen during a persons lifetime. Why this happens to a given individual is unknown in most cases.. ...
http://www.nyhq.org/diw/Content.asp?PageID=DIW000107&More=DIW
Novartis announces data show majority of patients with polycythemia vera treated with Jakavi® achieved long-term disease...Novartis announces data show majority of patients with polycythemia vera treated with Jakavi® achieved long-term disease...
Basel, June 13, 2015 - Novartis today announced long-term safety and efficacy results from the pivotal Phase III RESPONSE study evaluating Jakavi® (ruxolitinib) for the treatment of patients with polycythemia vera (PV) who are resistant to or intolerant of hydroxyurea. A preplanned analysis of the study at 18 months demonstrated that 80% of patients with inadequately controlled PV treated with Jakavi experienced a durable response of sustaining hematocrit less than 45% without the use of phlebotomy and reducing spleen size, two key measures of disease control, for at least one year[1]. Findings were presented at the 20th Congress of the European Hematology Association (EHA) in Vienna, Austria.. Polycythemia vera can lead to serious complications if inadequately controlled, and these data demonstrate the ability of Jakavi to provide a durable and comprehensive clinical benefit in this patient population, said lead study investigator Jean-Jacques Kiladjian, MD, PhD, Hôpital Saint-Louis et ...
https://www.novartis.com/news/media-releases/novartis-announces-data-show-majority-patients-polycythemia-vera-treated-jakavi-achieved-long-term-disease-control
Polycythemia Vera in ChildrenPolycythemia Vera in Children
Polycythemia vera is a serious, but very rare blood disorder in children. With polycythemia vera, the bone marrow makes too many red blood cells. The extra cells make the blood too thick. This may lead to blood clots. The clots can decrease the blood supply to organs, tissues, and cells.
http://library.covenanthealth.com/Library/DiseasesConditions/Pediatric/90,P02398
THE ASSOCIATION OF POLYCYTHEMIA VERA AND PEPTIC ULCER* | Annals of Internal Medicine | American College of PhysiciansTHE ASSOCIATION OF POLYCYTHEMIA VERA AND PEPTIC ULCER* | Annals of Internal Medicine | American College of Physicians
Our interest was aroused in the significance of the association of duodenal ulcer and polycythemia vera as a result of observation of a patient who had both diseases. A review of the literature revealed interesting speculations in regard to the association of these conditions because of recent demonstrations of the relation of gastric secretion and hematopoietic function. It seemed reasonable that with the large amount of material available at this clinic some conclusions might be drawn as to the incidence of association of these diseases.. In the available medical textbooks, the gastrointestinal symptoms associated with polycythemia vera are minimized. Osler1 ...
https://annals.org/aim/article-abstract/670833/association-polycythemia-vera-peptic-ulcer
Polycythemia vera CT - wikidocPolycythemia vera CT - wikidoc
There are no CT scan findings associated with polycythemia vera. However, a CT scan may be helpful in the diagnosis of complications of polycythemia vera, which include:[1][2] ...
http://wikidoc.org/index.php/Polycythemia_vera_CT
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. - Centre for Tropical Medicine and Global...
Human myeloproliferative disorders form a range of clonal haematological malignant diseases, the main members of which are polycythaemia vera, essential thrombocythaemia, and idiopathic myelofibrosis. The molecular pathogenesis of these disorders is unknown, but tyrosine kinases have been implicated in several related disorders. We investigated the role of the cytoplasmic tyrosine kinase JAK2 in patients with a myeloproliferative disorder.We obtained DNA samples from patients with polycythaemia vera, essential thrombocythaemia, or idiopathic myelofibrosis. The coding exons of JAK2 were bidirectionally sequenced from peripheral-blood granulocytes, T cells, or both. Allele-specific PCR, molecular cytogenetic studies, microsatellite PCR, Affymetrix single nucleotide polymorphism array analyses, and colony assays were undertaken on subgroups of patients.A single point mutation (Val617Phe) was identified in JAK2 in 71 (97%) of 73 patients with polycythaemia vera, 29 (57%) of 51 with essential
https://www.tropicalmedicine.ox.ac.uk/publications/998683
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. - Centre for Tropical Medicine and Global...
Human myeloproliferative disorders form a range of clonal haematological malignant diseases, the main members of which are polycythaemia vera, essential thrombocythaemia, and idiopathic myelofibrosis. The molecular pathogenesis of these disorders is unknown, but tyrosine kinases have been implicated in several related disorders. We investigated the role of the cytoplasmic tyrosine kinase JAK2 in patients with a myeloproliferative disorder.We obtained DNA samples from patients with polycythaemia vera, essential thrombocythaemia, or idiopathic myelofibrosis. The coding exons of JAK2 were bidirectionally sequenced from peripheral-blood granulocytes, T cells, or both. Allele-specific PCR, molecular cytogenetic studies, microsatellite PCR, Affymetrix single nucleotide polymorphism array analyses, and colony assays were undertaken on subgroups of patients.A single point mutation (Val617Phe) was identified in JAK2 in 71 (97%) of 73 patients with polycythaemia vera, 29 (57%) of 51 with essential
https://www.tropicalmedicine.ox.ac.uk/publications/998683/
types of polycythemiatypes of polycythemia
The most common are polycythemia vera, essential thrombocythemia, primary myelofibrosis, and chronic myelogenous leukemia (CML). The signs and symptoms of PV include: Polycythemia: Types list. Though there is no known cure for the disorder, there are many different types of polycythemia vera treatment to help lower a patients blood cell counts, decrease the viscosity of the blood, and prevent bleeding or clotting. When signs and symptoms are present, theyre the result of the thick blood that occurs with PV. It is most commonly found by doctors in men over 60 years of age. Signs may include: An increase in red blood cells, platelets and white bloods cells A high hematocrit (the proportion of red blood cells in the blood) An increase in hemoglobin concentration (a protein found in red blood cells) Low levels of erythropoietin (a hormone that controls red blood cell production) Additional tests may include: Secondary polycythemia - also called reactive polycythemia - is characterized by excessive ...
https://schoolwebpages.com/who-is-xyp/0c8c34-types-of-polycythemia
Polycythemia veraPolycythemia vera
Kremyanskaya M, Najfeld V, Mascarenhas J, Hoffman R. The polycythemias. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 68. National Cancer Institute website. Chronic myeloproliferative neoplasms treatment (PDQ) -- health professional version. www.cancer.gov/types/myeloproliferative/hp/chronic-treatment-pdq#link/_5. Updated February 1, 2019. Accessed March 1, 2019. Tefferi A. Polycythemia vera, essential thrombocythemia, and primary myelofibrosis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 166. BACK TO TOP Review Date: 1/29/2019 Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.. ...
http://slu.adam.com/content.aspx?productid=617&pid=1&gid=000589
Polycythemia | RxHealthMedPolycythemia | RxHealthMed
The word polycythemia simply means many cells in the blood. There are two forms of this disease: polycythemia vera and secondary polycythemia. Polycythemia vera (also called primary polycythemia) is a rare growth disorder of the bone marrow, occurring when the marrow is overactive and produces more blood cells than the…
https://www.rxhealthmed.ca/condition/polycythemia/
A prospective study of 338 patients with polycythemia vera: the impact of JAK2 (V617F) allele burden and leukocytosis on...A prospective study of 338 patients with polycythemia vera: the impact of JAK2 (V617F) allele burden and leukocytosis on...
We studied the relationship between JAK2 (V617F) mutant allele burden and clinical phenotype, disease progression and survival in patients with polycythemia vera (PV). The percentage of granulocyte mutant alleles was evaluated using a quantitative real-time polymerase chain reaction-based allelic discrimination assay. Of the 338 patients enrolled in this prospective study, 320 (94.7%) carried the JAK2 (V617F) mutation. Direct relationships were found between mutant allele burden and hemoglobin concentration (P=0.001), white blood cell count (P=0.001), spleen size (P=0.001) and age-adjusted bone marrow cellularity (P=0.002), while an inverse relationship was found with platelet count (P,0.001). During the study period, eight patients progressed to post-PV myelofibrosis (MF) (all carrying ,50% mutant alleles), while 10 patients developed acute myeloid leukemia (AML). The mutant allele burden was significantly related to the risk of developing myelofibrosis (P=0.029) and retained its significant ...
https://iris.unipv.it/handle/11571/216302
Serum Vitamin B12 Content and Unsaturated Vitamin B12-Binding Capacity in Myeloproliferative DiseaseValue in Differential...Serum Vitamin B12 Content and Unsaturated Vitamin B12-Binding Capacity in Myeloproliferative DiseaseValue in Differential...
SUMMARY. The serum unsaturated vitamin B12-binding capacity (UBBC) was found to be of value in distinguishing polycythemia vera from other conditions that are accompanied by an elevated hematocrit or an absolute erythrocytosis and as an indicator of disease activity in polycythemia vera. The serum vitamin B12 level was of lesser value. Increased levels of serum vitamin B12 were observed in 36% and increased levels of UBBC in 70% of patients with untreated polycythemia vera and related myeloproliferative disorders, as contrasted with normal serum vitamin B12 levels in 98% and normal UBBC in 87% of cases of spurious (relative) polycythemia and isolated erythrocytosis (secondary and unclassified polycythemia). Serum vitamin B12 and UBBC levels in polycythemia vera treated only with phlebotomy did not differ from values in untreated cases, whereas patients whose erythroid activity had been controlled by myelosuppressive therapy had levels comparable to those in normal subjects. UBBC values were ...
http://annals.org/aim/article-abstract/683580/serum-vitamin-b-12-content-unsaturated-vitamin-b-12-binding
More For Polycythemia Vera Patients | MPNRF BlogMore For Polycythemia Vera Patients | MPNRF Blog
Interested in reading about living with PV, ET or MF? The MPN Research Foundation blog is all about MPN research, patients and treatments. Come learn more!
http://www.mpnresearchfoundation.org/blog/polycythemia-vera
Jerry Spivak LabJerry Spivak Lab
Research in the Jerry Spivak Lab focuses on chronic myeloproliferative disorders, particularly their molecular mechanisms and methods for distinguishing them diagnostically and interventionally. By analyzing gene expression in polycythemia vera stem cells, we have learned that patients with polycythemia vera can be differentiated from those with erythrocytosis and can be diagnosed as having either aggressive or slow-growing disease. We are also studying the roles played by specific molecular markers in the pathogenesis and diagnosis of polycythemia vera.. Research Areas: stem cells, pathogenesis, polycythemia vera, myeloproliferative disorders ...
https://www.hopkinsmedicine.org/research/labs/jerry-spivak-lab
Patients with polycythemia vera have worst impairment of quality of life among patients with newly diagnosed myeloproliferative...Patients with polycythemia vera have worst impairment of quality of life among patients with newly diagnosed myeloproliferative...
The quality of life (QoL) at the time of diagnosis of myeloproliferative neoplasm (MPN) has, to date, not been studied. One hundred and seventy-nine patients with MPN: 80 with essential thrombocythemia (ET), 73 with polycythemia vera (PV), 22 with primary myelofibrosis (PMF) and four with MPN undifferentiated, were included in this study. European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQC30) and the MPN-Symptom Assessment Form (MPN-SAF) were used to evaluate QoL. Fatigue was the most reported symptom in these patients. Patients with PV reported significantly higher mean scores for inactivity, dizziness, cough, itching, depression and lower total QoL compared to patients with ET. Patients with PV had significantly more headache and itching compared to patients with PMF. When the newly diagnosed patients with MPN were compared with a cohort of patients with MPN with mean disease duration of 7.8 years, the differences were most striking for ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:661436
MPD-RC
mpdrc.org: mpdrc, mpd-rc, MPD-RC, polycythemia vera, polycythaemia vera, polycythemia rubra, polycythemia, thrombocytemia vera, thrombocythaemia vera, essential thrombocythemia, thrombocythemia, idiopatic myelofibrosis, primary myelofibrosis, myelofibrosis, myeloproliferative disordes, myeloproliferative, myeloproliferarive disease, myeloproliferative disorders research consortium, hematocrit, platelets, negrisud, negri sud, mario negri, mario negri sud, marionegrisud
http://mpdrc.org/privatearea/login.php
Ruxolitinib and interferon-α2 combination therapy for patients with polycythemia vera or myelofibrosis - Research -...
We report the final two-year end-of-study results from the first clinical trial investigating combination treatment with ruxolitinib and low-dose pegylated interferon-α2 (PEG-IFNα2). The study included 32 patients with polycythemia vera (PV) and 18 with primary- or secondary myelofibrosis (MF); 46 patients were previously intolerant or refractory to PEG-IFNα2. The primary outcome was efficacy, based on hematological parameters, quality of life measurements, and JAK2 V617F allele burden. We used the 2013 ELN and IWG-MRT response criteria, including response in symptoms, splenomegaly, peripheral blood counts, and bone marrow. Of 32 patients with PV, 10 (31%) achieved remission; 3 (9%) achieved complete remission. Of 18 patients with MF, 8 (44%) achieved remission; 5 (28%) achieved complete remission. The cumulative incidence of peripheral blood count remission was 0.85 and 0.75 for patients with PV and MF, respectively. MPN-SAF total symptom score decreased from 22 (95%CI, 16-29) at baseline to ...
https://research.regionh.dk/rigshospitalet/en/publications/ruxolitinib-and-interferon2-combination-therapy-for-patients-with-polycythemia-vera-or-myelofibrosis
A clinical-molecular prognostic model to predict survival in patients with post polycythemia vera and post essential...A clinical-molecular prognostic model to predict survival in patients with post polycythemia vera and post essential...
Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms with variable risk of evolution into post-PV and post-ET myelofibrosis, from now on referred to as secondary myelofibrosis (SMF). No specific tools have been defined for risk stratification in SMF. To develop a prognostic model for predicting survival, we studied 685 JAK2, CALR, and MPL annotated patients with SMF. Median survival of the whole cohort was 9.3 years (95% CI: 8-not reached-NR-). Through penalized Cox regressions we identified negative predictors of survival and according to beta risk coefficients we assigned 2 points to hemoglobin level |11 g/dl, to circulating blasts ⩽3%, and to CALR-unmutated genotype, 1 point to platelet count |150 × 109/l and to constitutional symptoms, and 0.15 points to any year of age. Myelofibrosis Secondary to PV and ET-Prognostic Model (MYSEC-PM) allocated SMF patients into four risk categories with different survival (P|0.0001): low (median survival NR; 133 patients),
https://www.nature.com/articles/leu2017169.epdf?no_publisher_access=1&r3_referer=nature&error=cookies_not_supported&code=f0d3e797-b584-4f8b-87c2-bc59e1328a59
Polycythemia vera | SpringerLinkPolycythemia vera | SpringerLink
Of 113 Patients with polycythemia vera (P. vera) who had been followed for the last 8 years, 30 cases (27%) developed myeloid leukemia with fibrosis of the bone marrow. Core biopsies of the bone...
https://link.springer.com/article/10.1007/BF00430658
Polycythemia vera ultrasound - wikidocPolycythemia vera ultrasound - wikidoc
Abdominal ultrasound may be helpful in the diagnosis of myeloproliferative neoplasm. Findings on abdominal ultrasound suggestive of myeloproliferative neoplasm include splenomegaly, abdominal fluid, and hepatic lesions. Ultrasound of the extremities can assist with diagnosis of deep vein thrombosis, which is commonly associated with high-risk polycythemia vera. ...
http://wikidoc.org/index.php/Polycythemia_vera_ultrasound
Polycythemia vera | Phlebotomy. Cancer: Treatment in Germany, Frankfurt am Main hospitals on BookingHealth.comPolycythemia vera | Phlebotomy. Cancer: Treatment in Germany, Frankfurt am Main hospitals on BookingHealth.com
Polycythemia vera | Phlebotomy. Cancer: Treatment in Frankfurt am Main, Germany ✈. Prices on BookingHealth.com - booking treatment online!
https://bookinghealth.com/programs/treatment/cancer/polycythemia-vera-phlebotomy/germany/frankfurt-am-main
Phlebotomy in polycythemia vera: Costs for treatment #234753 in Germany | BookingHealthPhlebotomy in polycythemia vera: Costs for treatment #234753 in Germany | BookingHealth
Phlebotomy in polycythemia vera (costs for program #234753) ✔ University Hospital Ulm ✔ Department of Hematology, Oncology, Rheumatology ✔ BookingHealth.com
https://bookinghealth.com/university-hospital-ulm/treatment-programs/234753-phlebotomy-in-polycythemia-vera.html
Advanced Polycythemia Vera (PV) | Proactively Identify Clinical Characteristics | Jakafi HCPAdvanced Polycythemia Vera (PV) | Proactively Identify Clinical Characteristics | Jakafi HCP
Advanced polycythemia vera (PV) may occur in a subset of patients with elevated hematocrit levels plus elevated white blood cell counts or disease related symptoms, despite treatment with HU at the maximum tolerated dose and phlebotomy.
https://hcp.jakafi.com/polycythemia-vera/advanced-pv
Polycythemia VeraPolycythemia Vera
Polycythemia vera is a rare blood disorder that occurs more often in men than in women. Its rarely seen in anyone under age 40. PV is usually associated with a gene mutation called JAK2 V617F. The JAK2 gene handles production of a protein that helps make blood cells. About 95 percent of people with PV have this mutation.. Mutations are changes or damage in the bodys DNA. DNA is responsible for all of your physical characteristics, from eye color to fingerprints. The mutation that causes PV can be acquired, which means something has damaged the DNA (instead of being born with it) and passed on within families. More research needs to be done to understand what causes the genetic mutation behind PV.. If you have PV, the genetic mutation causes your bone marrow to produce too many red blood cells. The production of red blood cells within your bone marrow is normally tightly regulated. Having too many red blood cells in your bloodstream can cause the blood to clot and lead to dangerous ...
https://www.aarpmedicareplans.com/health/polycythemia-vera
Diagnosis of Intermediate-Risk Polycythemia VeraDiagnosis of Intermediate-Risk Polycythemia Vera
In this case-based interview, Ruben A. Mesa, MD, discusses the case of a young male patient with polycythemia vera not adequately controlled on phlebotomy and hydroxyurea.
http://www.targetedonc.com/case-based-peer-perspectives/myeloproliferative-neoplasms/mesa-hydroxyurea-resistant/diagnosis-of-intermediate-risk-polycythemia-vera
Inadequately Controlled Polycythemia VeraInadequately Controlled Polycythemia Vera
In this case-based interview, Ruben A. Mesa, MD, discusses the case of a young male patient with polycythemia vera not adequately controlled on phlebotomy and hydroxyurea.
http://www.targetedonc.com/case-based-peer-perspectives/myeloproliferative-neoplasms/mesa-hydroxyurea-resistant/inadequately-controlled-polycythemia-vera
Germline genetic factors influence the outcome of interferon-α therapy in polycythemia vera | Blood | American Society of...Germline genetic factors influence the outcome of interferon-α therapy in polycythemia vera | Blood | American Society of...
Interferon-α (IFNα) therapy can induce both hematologic responses (HR) and molecular responses (MR) in polycythemia vera (PV). Jäger and colleagues investigated
https://ashpublications.org/blood/article/137/3/387/463332/Germline-genetic-factors-influence-the-outcome-of
Phyllis George dies from Polycythemia Vera complications | PV ReporterPhyllis George dies from Polycythemia Vera complications | PV Reporter
Phyllis George, former sportscaster and Miss America, dies at 70 from complications related to polycythemia vera (PV), an uncommon blood cancer.
https://www.pvreporter.com/celebrity-tv-sports-broadcaster-phyllis-george-dies-from-polycythemia-vera-pv-related-complications/
Polycythemia vera - Canadian Cancer SocietyPolycythemia vera - Canadian Cancer Society
Polycythemia vera (PV) develops when the body makes too many red blood cells and sometimes too many white blood cells or platelets. Learn about PV.
https://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/polycythemia-vera/?region=ns
Ask the Expert: Polycythemia Vera, Essential Thrombocythemia and MyelofibrosisAsk the Expert: Polycythemia Vera, Essential Thrombocythemia and Myelofibrosis
Ruben A. Mesa, MD recently participated in the CancerConnect guest moderator series on myeloproliferative neoplasms (MPN). Dr. Mesa answered your questions about polycythemia vera, essential thrombocythemia and myelofibrosis in the MPN Community on CancerConnect. CancerConnect is a safe and private online support community for cancer patients and caregivers.. Dr. Mesa is a Director at UT Health San Antonio Cancer Center. He is committed to improving therapies and quality of life for patients with myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia and myelofibrosis. Join the Conversation and Check out the Q&A with Dr. Mesa. The Q&A session with Dr. Mesa is available on CancerConnect in the MPN support community and can be accessed here or in the discussions below. To maintain the privacy of our members, access to the Q&A will require registration or login.. ...
http://news.cancerconnect.com/have-a-question-about-myeloproliferative-neoplasms-join-us-on-july-23rd/
Mutations profile of polycythemia vera and essential thrombocythemia among Japanese children<...
TY - JOUR. T1 - Mutations profile of polycythemia vera and essential thrombocythemia among Japanese children. AU - Ismael, Olfat. AU - Shimada, Akira. AU - Hama, Asahito. AU - Sakaguchi, Hiroshi. AU - Doisaki, Sayoko. AU - Muramatsu, Hideki. AU - Yoshida, Nao. AU - Ito, Masafumi. AU - Takahashi, Yoshiyuki. AU - Akita, Naohiro. AU - Sunami, Shosuke. AU - Ohtsuka, Yoshitoshi. AU - Asada, Youji. AU - Fujisaki, Hiroyuki. AU - Kojima, Seiji. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2012/9. Y1 - 2012/9. N2 - Background: Acquired somatic mutations of JAK2 have been reported to play a pivotal role in the pathogenesis of BCR-ABL1-negative myeloproliferative neoplasm (MPN). However, the molecular characteristics of childhood MPN remain to be elucidated. Patient and Methods: We investigated a group of pediatric patients diagnosed either with essential thrombocythemia (ET; N=9) or polycythemia vera (PV; N=4) according to WHO criteria (median age=10 years; range 1.5-15 years) ...
https://okayama.pure.elsevier.com/en/publications/mutations-profile-of-polycythemia-vera-and-essential-thrombocythe
A Phase 2/3 Study of Pacritinib in Patients With Primary Myelofibrosis Post Polycythemia Vera Myelofibrosis or Post-Essential...A Phase 2/3 Study of Pacritinib in Patients With Primary Myelofibrosis Post Polycythemia Vera Myelofibrosis or Post-Essential...
Clinical trial for Post-essential Thrombocythemia Myelofibrosis | Post-polycythemia Vera Myelofibrosis | Myelosclerosis with myeloid metaplasia | Myelofibrosis | Post Essential Thrombocythemia Myelofibrosis , A Phase 2/3 Study of Pacritinib in Patients With Primary Myelofibrosis Post Polycythemia Vera Myelofibrosis or Post-Essential Thrombocythemia Myelofibrosis
https://www.centerwatch.com/clinical-trials/listings/119533/primary-myelofibrosis-phase-23-study-pacritinib/?geo_lat=40.7229&geo_lng=-73.8473&radius=10&place=Forest%20Hills
How to Apply for Social Security Disability with Polycythemia VeraHow to Apply for Social Security Disability with Polycythemia Vera
If you suffer from polycythemia vera, which is a serious disease that can result in death, you may be unable to work. In those situations, you may qualify for Social Security disability benefits. The Social Security Administration (SSA) oversees the Social Security Disability Insurance (SSDI) program, which provides monthly benefits to disabled workers. In order to be eligible for SSDI, you have to have worked enough to pay in sufficient taxes to the SSA and to have earned an adequate amount of credits. The monthly benefits paid through SSDI can help relieve the financial stress of being unable to work. In some instances, you may have dependents who are also eligible to receive benefits if you approved. Polycythemia vera is a disorder that impacts the bodys bone marrow. If you suffer from this condition, your body creates too many red blood cells, platelets, and white blood cells. The over-production of red blood cells can cause a variety of symptoms, including some which are life-threatening. ...
https://www.disabilitybenefitscenter.org/social-security-disabling-conditions/polycythemia-vera
Rapid decline of JAK2V617F levels during hydroxyurea treatment in patients with polycythemia vera and essential thrombocythemia...Rapid decline of JAK2V617F levels during hydroxyurea treatment in patients with polycythemia vera and essential thrombocythemia...
In polycythemia vera (PV) and essential thrombocythemia (ET) the discovery of the presence of JAK2V617F mutations indicates that tyrosine kinase activation is a common pathogenetic mechanism in Ph- MPD.1 The main therapeutic goal is to diminish the risk of clinical complications without increasing the risk of the development of myelofibrosis or acute leukemia. Hydroxyurea (HU) is widely used as a first line myelosuppressive therapy for patients with PV and ET.2,3 The control of the thrombocytosis is usually rapid and effective with initial treatment with HU,2 but the effect upon the JAK2V617F allele burden has not been studied. The JAK2V617F expression has been shown to decrease with IFN therapy and in some patients the mutated clone even seems to be eradicated.4 The aim of this study was to investigate the JAK2V617F response of HU treatment in newly diagnosed patients with PV or ET. Nine patients with PV and 9 with ET positive for JAK2V617F with high risk MPD3 and need for myelosuppressive ...
http://www.haematologica.org/content/93/8/1260
Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET...Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET...
The Philadelphia chromosome negative myeloproliferative neoplasms (MPN) are a group of clonal hematological malignancies that are characterized by a chronic course which can be punctuated by a number of disease related events including thrombosis, hemorrhage, pruritis and leukemic transformation. These disorders include Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PM). Recently an acquired somatic mutation in the intracellular kinase, JAK2 (JAK2V617F) has been observed in 95% of patients with PV, 50% of patients with ET and 50% of patients with primary myelofibrosis. At present the chemotherapeutic agent hydroxyurea is the standard of care for high risk patients with PV. Concern exists about prolonged use of this drug leading to leukemia and the inability of hydroxyurea to eliminate the malignant clone.. Interferon (rIFN -2b), is a drug that appears to be non-leukemogenic, and may have a preferential activity on the malignant clone in PV, as suggested by ...
https://clinicaltrials.gov/ct2/show/NCT01259856?term=Polycythemia+Vera&recr=Open&fund=01&rank=1
Paraplegia due to extramedullary hematopoiesis in thalassemia treated successfully with radiation therapy | HaematologicaParaplegia due to extramedullary hematopoiesis in thalassemia treated successfully with radiation therapy | Haematologica
Extramedullary hematopoiesis (EMH) can occur in many disorders including thalassemias, polycythemia rubra vera, myelofibrosis, hemolytic anemia and other hemoglobinopathies. Spinal cord compression due to EMH in thalassemia was first reported by Gatto in 1954.2 It usually has a predilection for the lower thoracic spine where the limited mobility and narrow spinal canal predisposes itself to spinal cord compression.3,6 Most cases present with paraparesis, sensory impairment and occasionally sphincter disturbances. Complete paraplegia has been reported very rarely in thalassemia and occurs more frequently in polycythemia rubra vera and sickle cell anemia.1 The diagnostic procedure of choice is magnetic resonance imaging (MRI) which characteristerically shows an isointense mass with a high spinal intensity rim on T1-weighted images and a hyperintense mass on T2-weighted images.4 The diagnosis is based on strong clinical suspicion in the presence of diffuse bone marrow hyperplasia along with ...
http://www.haematologica.org/content/92/3/e28
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with...Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with...
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis Academic Article ...
http://vivo.med.cornell.edu/display/pubid20244369569
Methylation of SOCS3 in Myeloproliferative Neoplasms and Secondary Erythrocytosis/Thrombocythemia [Turk J Hematol]Methylation of SOCS3 in Myeloproliferative Neoplasms and Secondary Erythrocytosis/Thrombocythemia [Turk J Hematol]
OBJECTIVE: Myeloproliferative neoplasms (MPNs) like essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) are acquired clonal hematopoietic stem cell disorders and originate from a multipotent hematopoietic stem cell. The SOCS1 and SOCS3 genes are negative regulators of the JAK/STAT signal pathway. In this study we investigate the promoter methylation of these genes in the pathogenesis of MPNs and secondary erythrocytosis/thrombocythemia ...
http://www.tjh.com.tr/jvi.aspx?pdir=tjh&plng=eng&un=TJH-98474&look4=
Management of polycythaemia in adults with cyanotic congenital heart disease | HeartManagement of polycythaemia in adults with cyanotic congenital heart disease | Heart
A number of widely held misconceptions result in inappropriate venesection. First, that it is performed to prevent the risk of stroke, therefore secondly, that it should be done routinely to keep the haematocrit , 65% regardless of symptoms, and thirdly that volume replacement is not required.. The idea that hyperviscosity is a risk factor for cerebral arterial thrombosis in adults with cyanotic heart disease has arisen from studies in other patient groups. This, along with the observation that symptoms of reduced cerebral blood flow secondary to hyperviscosity are transiently relieved by venesection, has led to the widespread belief that haematocrit levels in patients with cyanotic heart disease should not be allowed to rise too high.. The risk of vascular occlusion in patients with primary polycythaemia rubra vera relates both to degree of erythrocytosis and to thrombocytosis, and treatment guidelines in this disease recommend venesection to maintain a haematocrit ⩽ 45.2 6Haematologists ...
https://heart.bmj.com/content/79/4/315?ijkey=e495770d6a42e6c29af991da6a3f5b80b999a677&keytype2=tf_ipsecsha
Clinical significance of neutrophil CD177 mRNA expression in Ph-negative chronic myeloproliferative disorders | IRIS UNIPVClinical significance of neutrophil CD177 mRNA expression in Ph-negative chronic myeloproliferative disorders | IRIS UNIPV
The PRV-1 gene has been proposed as a marker of polycythaemia vera (PV). PRV-1 and NB1 are alleles of the polymorphic gene CD177, which belongs to the Ly-6/uPAR superfamily, and their coding regions differ at only four nucleotides. We studied neutrophil CD177 mRNA levels in normal subjects and in 235 patients with Ph-negative chronic myeloproliferative disorders (CMD), including PV, essential thrombocythaemia and myelofibrosis with myeloid metaplasia. Additional disease states were investigated for comparison. Highly variable neutrophil CD177 mRNA levels were observed in normal individuals. Neutrophils isolated from the bone marrow, or from peripheral blood following granulocyte colony-stimulating factor administration showed markedly higher CD177 expression than circulating granulocytes on steady state. Increased neutrophil CD177 mRNA levels were detected in all CMD. Elevated values were also found in reactive conditions and in disorders such as chronic myeloid leukaemia and myelodysplastic ...
https://iris.unipv.it/handle/11571/115818
Diagnostic refinement of chronic myeloproliferative disorders and thrombocytoses of unknown origin by multiple RT-PCR and...
TY - JOUR. T1 - Diagnostic refinement of chronic myeloproliferative disorders and thrombocytoses of unknown origin by multiple RT-PCR and capillary electrophoresis of BCR-ABL rearrangements and JAK2 (V617F) mutation. AU - Ammatuna, Emanuele. AU - Ottone, Tiziana. AU - Zaza, Serena. AU - Lavorgna, Serena. AU - Grillo, Rosa. AU - Curzi, Paola. AU - Panetta, Paola. AU - Federici, Giorgio. AU - Amadori, Sergio. AU - Lo-Coco, Francesco. PY - 2007/5. Y1 - 2007/5. N2 - Detection of genetic markers improves diagnostic refinement of chronic myeloproliferative disorders (CMDs) and is helpful in discriminating reactive conditions mimicking CMDs such as reactive erythrocytosis and thrombocytosis. We set-up a multiplex real-time polymerase chain reaction assay followed by capillary electrophoresis, designed to simultaneously screen the two main genetic lesions associated with CMDs, i.e. the BCR-ABL fusion characteristic of chronic myeloid leukemia and the JAK2 V617F mutation that characterises polycythaemia ...
https://moh-it.pure.elsevier.com/en/publications/diagnostic-refinement-of-chronic-myeloproliferative-disorders-and
Diagnosis and Treatment of Erythrocytosis - touchONCOLOGYDiagnosis and Treatment of Erythrocytosis - touchONCOLOGY
An erythrocytosis arises when the red cell mass is increased. This can be due to a primary intrinsic defect in the erythroid progenitor cells or secondary to erythropoietin production from some source. Primary and secondary causes can be congenital or acquired. Rare, primary congenital defects are due to mutations leading to truncation of the erythropoietin receptor. The main acquired, primary erythrocytosis is polycythaemia vera. Among the congenital secondary causes, a number of defects in the genes in the oxygen-sensing pathway have recently been described, which lead to a secondary erythrocytosis. An extensive list of acquired secondary causes needs to be considered. A number of patients do not have an identifiable cause of erythrocytosis and are therefore described as having idiopathic erythrocytosis. Investigation should commence with careful clinical evaluation. Determination of the erythropoietin level is then a first step to guide the further direction of investigation. In those with ...
https://touchoncology.com/haematology/journal-articles/diagnosis-and-treatment-of-erythrocytosis/
Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulationPhiladelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation
Conclusions:. Essential thrombocythemia, primary myelofibrosis, and polycythemia vera patients exhibited different patterns of cytokine production, as revealed by cytokine network correlations. Together, these findings suggest that augmented cytokine levels are associated with the physiopathology of myeloproliferative neoplasms. ...
http://www.scielo.br/scielo.php?script=sci_abstract&pid=S2531-13792018000200120&lng=pt&nrm=iso
JAK2 V617F mutation is rare in idiopathic erythrocytosis: a di...JAK2 V617F mutation is rare in idiopathic erythrocytosis: a di...
JAK2 V617F mutation is rare in idiopathic erythrocytosis: a difference from polycythemia vera.: A single mutation 1849G|T in the JAK2 gene (V617F) has recently
https://www.mysciencework.com/publication/show/jak2-v617f-mutation-rare-idiopathic-erythrocytosis-difference-from-polycythemia-vera-c5abda75
Contact Us - Aloe Vera Benefits
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The use of Aloe Vera as one of the ingredients for topical male enhancement treatment will enable skin to absorb the other beneficial component easier. New Chapters proven fermentation method delivers Aloe in its truest form, made easily digestible by fermenting with our clinically studied strains of probiotics. USE ALOE VERA AS A FOLIAR SPRAY Aloe Vera Powder Aloe vera powder is made by drying the Aloe leaf and its inner gel-like substance. 11 Best Benefits And Uses Of Aloe Vera Oil. Use in: Food and beverages. Kindly consult you physician before incorporating aloe vera in your diet. Aloe vera shampoo may also help improve blood circulation and keeps you away from stress and mental strain. Aloe vera is best known as being an ingredient in moisturizers and skin care treatments, but it is so much more versatile than that. Aloe Vera Powder Benefits Aloe vera is best known as being an ingredient in moisturizers and skin care treatments, but it is so much more versatile than that. Organic Aloe Vera ...
https://naidy.org.ua/5rb3ac/aloe-vera-powder-benefits-30120e
Post-Polycythemia Vera Myelofibrosis (PPV-MF) - PipelinePost-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline
Press release - ReportsWorldwide - Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline Review, H1 2017 - published on openPR.com
https://www.openpr.com/news/566681/post-polycythemia-vera-myelofibrosis-ppv-mf-pipeline-review-h1-2017.html
Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow...Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow...
An acquired somatic mutation, Jak2V617F, was recently discovered in most patients with polycythemia vera (PV), chronic idiopathic myelofibrosis (CIMF), and essential thrombocythemia (ET). To investigate the role of this mutation in vivo, we transplanted bone marrow (BM) transduced with a retrovirus expressing either Jak2 wild-type (wt) or Jak2V617F into lethally irradiated syngeneic recipient mice. Expression of Jak2V617F, but not Jak2wt, resulted in clinicopathologic features that closely resembled PV in humans. These included striking elevation in hemoglobin level/hematocrit, leukocytosis, megakaryocyte hyperplasia, extramedullary hematopoiesis resulting in splenomegaly, and reticulin fibrosis in the bone marrow. Histopathologic and flow cytometric analyses showed an increase in maturing myeloid lineage progenitors, although megakaryocytes showed decreased polyploidization and staining for acetylcholinesterase. In vitro analysis of primary cells showed constitutive activation of Stat5 and cytokine
https://www.semanticscholar.org/paper/Expression-of-Jak2V617F-causes-a-polycythemia-vera-Wernig-Mercher/771ff99d778d1f925441598c887570ab6284158e
Open Label Study to Evaluate the Activity of Imetelstat in Patients With Essential Thrombocythemia or Polycythemia Vera - Full...Open Label Study to Evaluate the Activity of Imetelstat in Patients With Essential Thrombocythemia or Polycythemia Vera - Full...
For patients with ET: To obtain a preliminary estimate of efficacy of imetelstat, as measured by best hematologic response within the first year of therapy in patients with ET who have failed or are intolerant to at least one prior therapy, or who have refused standard therapy.. For patients with PV: To obtain a preliminary estimate of efficacy of imetelstat, as measured by maintenance of Hct , 45% in men and , 42% in women (or pre-specified Hct count that is tolerable) without phlebotomy or myelosuppressive therapy within the first year of therapy in patients with PV who have failed or are intolerant to at least one prior therapy, or who have refused standard therapy. ...
https://clinicaltrials.gov/ct2/show/NCT01243073?term=McDevitt+AND+polycythemia+vera&rank=1
Busulfan in patients with polycythemia vera or essential thrombocythemia refractory or intolerant to hydroxyurea. | Sigma...Busulfan in patients with polycythemia vera or essential thrombocythemia refractory or intolerant to hydroxyurea. | Sigma...
Sigma-Aldrich offers abstracts and full-text articles by [Alberto Alvarez-Larrán, Luz Martínez-Avilés, Juan Carlos Hernández-Boluda, Francisca Ferrer-Marín, María Luisa Antelo, Carmen Burgaleta, M Isabel Mata, Blanca Xicoy, Alejandra Martínez-Trillos, M Teresa Gómez-Casares, M Antonia Durán, Bárbara Marcote, Agueda Ancochea, Alicia Senín, Anna Angona, Montse Gómez, Vicente Vicente, Francisco Cervantes, Beatriz Bellosillo, Carles Besses].
https://www.sigmaaldrich.com/catalog/papers/24981691
Study With SAR302503 in Patients With Polycythemia Vera or Essential ThrombocythemiaStudy With SAR302503 in Patients With Polycythemia Vera or Essential Thrombocythemia
Primary Objective: - Dose Ranging Phase: To evaluate the efficacy of daily oral doses of 100, 200, and 400 mg SAR302503 in patients with
http://www.knowcancer.com/cancer-trials/NCT01420783/
Chronic Myeloproliferative Disorders
Chronic myeloproliferative disorders are a group of slow-growing blood cancers in which the bone marrow makes too many abnormal red blood cells, white blood cells, or platelets, which accumulate in the blood. The type of myeloproliferative disorder is based on whether too many red blood cells, white blood cells, or platelets are being made. Sometimes the body will make too many of more than one type of blood cell, but usually one type of blood cell is affected more than the others are ...
http://diseaseinfosearch.org/Chronic+Myeloproliferative+Disorders/1624
Elevated Haematocrit in PV with Conventional Treatments | JAKAVIElevated Haematocrit in PV with Conventional Treatments | JAKAVI
Some Polycythemia Vera patients exhibit elevated haematocrit levels despite phlebotomy and/or cytoreductive therapy. Inability to achieve and consistently maintain haematocrit |45% can have serious consequences.
https://www.jakavi.com/en/polycythemia-vera/about-pv/elevated-haematocrit/
Antioxidant, Antibiotic, Antimicrobial, Antifungal, Antiseptic - What Isnt Aloe Vera Good For? | The Hearty SoulAntioxidant, Antibiotic, Antimicrobial, Antifungal, Antiseptic - What Isnt Aloe Vera Good For? | The Hearty Soul
The benefits of adding aloe vera to your diet are easy to see. With so many vital nutrients, this superfood should become a staple in your effort to leading a healthy life.. One popular way to have quick, easy access to this natural wonder is by growing your own aloe vera at home. Aloe vera grows quickly and reproduces at a high rate. For those looking to take an easier route, there are many products like juices and supplements available that can make adding aloe vera to your diet even easier.. When consuming aloe vera, in any form, nutrient content and bioavailability of key ingredients like acemannan is important. Ive actually created an excellent aloe vera supplement called Aloe Fuzionâ„¢, which is made from 100% organic inner leaf aloe vera.. If youre looking for a convenient, natural way to add an incredibly bioavailable form of aloe vera to your diet, you cannot go wrong with Aloe Fuzion.. ...
https://theheartysoul.com/is-it-safe-to-drink-aloe-vera/
Compare Prices on Aloe Vera Extract- Online Shopping/Buy Low Price Aloe Vera Extract at Factory Price | Aliexpress.com |...Compare Prices on Aloe Vera Extract- Online Shopping/Buy Low Price Aloe Vera Extract at Factory Price | Aliexpress.com |...
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Janus kinase 2 mutations in Philadelphia negative chronic myeloproliferative disorders: clinical implications. - Semantic...Janus kinase 2 mutations in Philadelphia negative chronic myeloproliferative disorders: clinical implications. - Semantic...
The chronic myeloproliferative disorders (CMPD) are a group of clinically related diseases characterized by clonal hematopoiesis with increased proliferation of one or more myeloid cell lineages. The identification of JAK2 mutations (JAK2V617F and JAK2 exon 12) in patients with CMPD is of great significance in the understanding of the molecular mechanisms underlined the pathogenesis of the disease contributing also to clinical management of patients. However, the precise pathogenetic contribution of JAK2 mutation is far from being fully elucidated and it is currently under intense investigation. Testing of JAK2 mutations has made the diagnosis of CMPD more precise than ever before, while genotype-phenotype associations have been identified. Furthermore, the discovery of JAK2 mutations facilitated the development of new targeted therapies and clinical trials are currently ongoing.
https://www.semanticscholar.org/paper/Janus-kinase-2-mutations-in-Philadelphia-negative-Panani/659dc7b5492c5a43889fc80791edfb927893223d
Acute embolic cerebral ischemia as an initial presentation of polycythemia vera: a case report | Journal of Medical Case...Acute embolic cerebral ischemia as an initial presentation of polycythemia vera: a case report | Journal of Medical Case...
PV is a myeloproliferative disorder resulting in an elevated absolute red blood cell mass because of uncontrolled red blood cell production. This is typically associated with an increase in WBC and PLT production. The increase in WBCs and PLTs is secondary to an abnormal clone of hematopoietic stem cells with increased sensitivity to different maturation growth factors. PV is overall rare, occurring in 0.6-1.6 persons per million population. The peak incidence of PV is 50-70 years of age. However, PV may occur in persons of all age groups, including young adults and children, albeit rarely [11].. The increased hematocrit of PV is the main determinant of blood viscosity. As the viscosity increases, cerebral blood flow decreases [6, 7]. PLT marginalization with increased contact to vessel walls occurs, along with local effect of a high hematocrit on vessel walls [6, 7]. This fulfils all three components of Virchows triad [12], and is consistent with the thought that many strokes in polycythemic ...
https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-7-131
Essential Thrombocythemia (ET) - MPN Advocacy & Education InternationalEssential Thrombocythemia (ET) - MPN Advocacy & Education International
Education, support, and resources for patients and caregivers with myelofibrosis, polycythemia vera, and essential thrombocythemia.
http://mpnadvocacy.com/understanding-mpns/essential-thrombocythemia/
Aloe Vera - A Natural Medicine for Good HealthAloe Vera - A Natural Medicine for Good Health
What is Aloe Vera? Aloe Vera is a short stem plant with green succulent leaves widely found in the tropical and sub tropical regions of the world. Aloe Vera is the oldest and famous medicinal plant that has been used for thousands of years in various cultures in traditional home remedies. It has excellent anti-bacterial, anti-viral, anti- fungal and anti-inflammatory properties and contains minerals and vitamins. It is used to treat a number of skin ailments and health conditions and is also used in the production of cosmetics like, hair gel, shampoos, body lotion, oil etc. Aloe Vera Oil Aloe Vera Oil is extracted from aloe vera plant. It is used to help recover from wounds and scars. It is also used as a moisturizer that works wonderfully for improving hair and skin conditions. The oil is also used to improve digestive system and help stabilize blood circulation. Aloe Vera oil penetrates into the skin quickly and deeply and heals, thus making the oil a natural choice for base oil in ...
http://greenyatra.blogspot.com/2014/03/aloe-vera-natural-medicine-for-good.html
Ayurvedic Properties and Benefits of Aloe Vera (Kumari) | ONLINE AYURVEDA
Benefits of drinking Aloe Vera Juice-. 1.Maintains good Liver function. Aloe vera juice is an excellent way to keep your liver healthy. Liver functions remain healthy when the body is adequately nourished and hydrated. Aloe vera juice is good for the liver functions because its hydrating and rich in many nutrients.. 2.Removes constipation. Drinking aloe vera juice helps increase the water content in your intestines. Research has shown a relationship between increasing the intestinal water content and the stimulation of peristalsis, which helps you pass stool normally.. 3.Clear skin. Hydrating aloe vera juice may help reduce the frequency and appearance of acne. It may also help to cure skin diseases like psoriasis, rash, and dermatitis.. Aloe vera juice contains antioxidants and vitamins that may help protect, heal your skin.. Important compounds in aloe vera juice have also been shown to neutralize the effects of UV radiation, repair your damaged skin, and help prevent fine lines and wrinkles ...
https://onlineayurveda.org/benefits-of-aloevera/
Aloe Vera Gelly - Produse Aloe vera ForeverAloe Vera Gelly - Produse Aloe vera Forever
În trecut, Aloe vera era întrebuinţată pentru tratarea leziunilor cutanate minore. În multe gospodării, planta crescută în ghiveci era folosită ca prim-ajutor pentru arsuri. De aceea, în esenţă identic cu sucul obţinut direct din frunza de aloe, gelul nostru stabilizat de Aloe vera lubrifiază şi cele mai sensibile epiderme. Aloe Vera Gelly, gel translucid ce conţine agenţi de hidratare şi umectare, a fost special creat pentru aplicare topică în regiunea care necesită calmarea rapidă a unor iritaţii, şi reface hidratarea şi catifelarea iniţială. Aloe Vera Gelly pătrunde rapid în piele şi nu pătează hainele.. Aloe Vera Gelly calmează leziunile cutanate minore. De asemenea, poate fi aplicat pe piele înaintea tratamentelor ultrasonice sau după electroliză.. Hair-styliştii folosesc produsul pentru protecţia scalpului înainte de vopsiri şi ondulaţii permanente. În dulăpiorul din baie, în trusa de prim-ajutor, în bucătărie, în tabără, Aloe Vera Gelly ...
http://produsealoe.ro/produse/aloe-vera-gelly/
Taxifolin be more effective in combination with existing drugs | Inhibitor|Kinase Inhibitors|tyrosine kinase inhibitor
S$90 million upfront, with up to $665 million in potential milestone payments. This followed soon after a deal in which Novartis acquired ex-US rights to INCB18424 - which is in Phase III trials for myelofibrosis - as well as the MET inhibitor INCB28060, for $150 million upfront and up to $1.1 billion in potential milestone payments. JAKs are a family of intracellular non-receptor tyrosine kinases that transduce cytokine-mediated signals via Taxifolin the JAK-STAT pathway. More than 20 clinical trials are currently investigating JAK inhibitors for treating diseases including autoimmune/ inflammatory disorders, cancer and several myeloproliferative disorders (Table 1).. Gain-of-function mutations in JAK2 have been found in a substantial proportion of patients with myeloproliferative disorders, including myelofibrosis, a debilitating disease that currently has no effective medications, as well as in patients with polycythaemia vera and essential thrombocythaemia. The potential causal role of JAK2 ...
https://ainhibitor.com/taxifolin-be-more-effective-in-combination-with-existing-drugs
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Super 8x Aloe Vera Gelly - My Nutritional Solutions
Nutritional Solutions Super 8X Aloe Vera Gelly is the most concentrated Aloe Vera gel developed for topical use. Rich in polysaccharides, daily use of Super 8X Aloe Gelly will promote healthy skin. This superior whole leaf aloe gel will remove oil and impurities from the skin.. Aloe Vera gets its reputation as the burn plant because of its ability to accelerate the healing process. Use Super 8X Aloe Vera Gelly as a dressing for burns and minor skin irritations to control pain and promote healing. Super 8X Aloe Gelly slows the skin aging process by increasing soluble collagen.. To help tighten facial skin, use Super 8X Aloe Gelly as a nighttime dressing. After cleansing your face before bedtime, apply Super 8X Aloe Vera Gelly. You will notice the difference that Super 8X Aloe Gelly make from the very first morning.. Super 8X Aloe Gelly promotes healthy gum tissue by controlling bacteria, which causes gingivitis and other gum diseases. Research has shown that Aloe Vera is effective in ...
https://www.mynutritionalsolutions.com/product/super-8x-aloe-vera-gelly/
Real Aloe, Aloe Vera Gel, 32 fl oz (960 ml) - iHerbReal Aloe, Aloe Vera Gel, 32 fl oz (960 ml) - iHerb
Recent studies show that taking supplements with Aloe Vera will increase the absorption of these supplements by up to 200% versus taking them with water.. RealAloe is one of the only Aloe Vera products on the market today that is 100% grown and bottled in the USA. If you are not drinking RealAloe, ask where your Aloe Vera is grown, processed and bottled. Many Aloe Vera products are made in Mexico, China and Korea.. Real Aloe History. RealAloe has been in the Aloe Vera Business since 1972. We use only fresh organic Aloe leaves grown in the USA. The Aloe Vera used in our products has never been frozen, freeze-dried, or reconstituted from powder. We believe the original method of hand filleting the leaves, allows us to maintain the maximum biological activity and effectiveness from the aloe leaf.. Real Aloe contains over 150 nutrients in a whole food form in trace amounts (parts per million or parts per billion).. RealAloe contains No synthetic nutrients.. Scientists have discovered over 150 ...
https://ph.iherb.com/pr/Real-Aloe-Aloe-Vera-Gel-32-fl-oz-960-ml/29035
Aloe VeraAloe Vera
Report Synopsis. In this report, Future Market Insights offers a 10-year forecast of the global aloe vera extracts market between 2016 and 2026. In terms of value, the market is expected to expand at a CAGR of 7.7%, during the projected period. The study presents insights on market dynamics and trends in all seven regions, which are expected to influence the current nature and future status of the global aloe vera extracts market over the forecast period. Report Description. In this report, Future Market Insights (FMI) analyses the global aloe vera extracts market for the period 2016-2026. The primary objective of the report is to offer updates on the advancements in the global aloe vera extracts market.. Rising disposable income along with increasing number of health-conscious customers are factors expected to expand growth of the global aloe vera extracts market over the forecast period. Besides this, increasing usage of aloe vera gel, capsules and powder for cosmetic and medicinal purposes is ...
https://www.futuremarketinsights.com/reports/aloe-vera-extracts-market
Aloe Vera RemediesAloe Vera Remedies
Aloe Vera Remedies. Aloe Vera has proven to be very effective in healing skin problems such as minor burns, and scratches. But unknown to many, it has been recently discovered that it is very useful in oral care as well.. Aloe Vera aids in the healing of gum problems. Gum diseases like gingivitis or periodontitis can be treated easily with this herb. Gingivitis caused by bacteria building up between the teeth and gums that cause inflammation and bleeding. It has been proven that Aloe Vera greatly reduces the instances of gum bleeding. With it soothing and healing properties, gums tend to stop the restored to health faster.. Periodontitis is the advanced case of gingivitis. Tooth loss apparent if you have periodontitis. Aloe Vera reduces the swelling of the gums, and the soft tissues in it. Once swelling is reduced, bleeding stops.. Aloe Vera is also known to have antifungal benefits. It prevents denture stomatitis, which is the redness and soreness of the mucous membranes covered permanently by ...
http://www.wsmagazine.net/aloe-vera-remedies/
DERMA ICE BURN RELIEF with Aloe Vera,DERMA ICE BURN RELIEF with Aloe Vera Uses,DERMA ICE BURN RELIEF with Aloe Vera side ...
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AloeVera Benefits Shop - Aloe Vera Benefits
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Effect of mutation order on myeloproliferative neoplasms. - Oxford Big Data Institute
BACKGROUND: Cancers result from the accumulation of somatic mutations, and their properties are thought to reflect the sum of these mutations. However, little is known about the effect of the order in which mutations are acquired. METHODS: We determined mutation order in patients with myeloproliferative neoplasms by genotyping hematopoietic colonies or by means of next-generation sequencing. Stem cells and progenitor cells were isolated to study the effect of mutation order on mature and immature hematopoietic cells. RESULTS: The age at which a patient presented with a myeloproliferative neoplasm, acquisition of JAK2 V617F homozygosity, and the balance of immature progenitors were all influenced by mutation order. As compared with patients in whom the TET2 mutation was acquired first (hereafter referred to as TET2-first patients), patients in whom the Janus kinase 2 (JAK2) mutation was acquired first (JAK2-first patients) had a greater likelihood of presenting with polycythemia vera than with
https://www.bdi.ox.ac.uk/publications/623509
Polycythemia veraPolycythemia vera
"Polycythemia vera - MayoClinic.com". Polycythemia vera: Definition. Mayo Clinic. Retrieved 2011-09-03. "What Is Polycythemia ... People with polycythemia vera can be asymptomatic. A classic symptom of polycythemia vera is pruritus or itching, particularly ... JAK2-positive polycythemia vera - diagnosis requires both criteria to be present: JAK2-negative polycythemia vera - diagnosis ... "Polycythemia Vera Follow-up". Retrieved 2011-09-03. "Highlights in Polycythemia Vera From the 2016 EHA Congres". Retrieved 2016 ...
https://en.wikipedia.org/wiki/Polycythemia_vera
Essential thrombocythemiaEssential thrombocythemia
No evidence of polycythemia vera hematocrit < midpoint of normal range or normal red cell mass in presence of normal iron ... Vannucchi, AM (June 2010). "Insights into the pathogenesis and management of thrombosis in polycythemia vera and essential ... Campbell PJ, Green AR (2005). "Management of Polycythemia Vera and Essential Thrombocythemia" (PDF). Hematology. 2005: 201-8. ... polycythemia vera and essential thrombocythemia: 2011 update on diagnosis, risk-stratification, and management". American ...
https://en.wikipedia.org/wiki/Essential_thrombocythemia
GivinostatGivinostat
... including polycythaemia vera. In patients with polycythaemia, the reduction of mutant JAK2 concentrations by givinostat is ... polycythaemia vera. and Duchenne muscular dystrophy. A preclinical study produced early results suggesting the molecule might ... "Treatment options for essential thrombocythemia and polycythemia vera". Expert Review of Hematology. 2 (1): 41-55. doi:10.1586/ ... Givinostat for the treatment of polycythaemia vera" (PDF). European Medicines Agency. "Potential treatment for diastolic ...
https://en.wikipedia.org/wiki/Givinostat
Diffusing capacityDiffusing capacity
Burgess, J. H.; Bishop, J. M. (1963). "Pulmonary Diffusing Capacity and ITS Subdivisions in Polycythemia Vera". Journal of ... polycythemia, left to right intracardiac shunts, due increase in volume of blood exposed to inspired gas. Asthma due to better ... More hemoglobin is present in polycythemia, and so D L C O {\displaystyle D_{L_{CO}}} is elevated. In anemia, the opposite is ...
https://en.wikipedia.org/wiki/Diffusing_capacity
Deep vein thrombosisDeep vein thrombosis
Reikvam H, Tiu RV (April 2012). "Venous thromboembolism in patients with essential thrombocythemia and polycythemia vera". ... polycythemia vera, essential thrombocythemia, intravenous drug use, and smoking. Some risk factors influence the location of ...
https://en.wikipedia.org/wiki/Deep_vein_thrombosis
Mir-339 microRNA precursor familyMir-339 microRNA precursor family
"Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis". Experimental Hematology. 35 (11): 1657-67. ...
https://en.wikipedia.org/wiki/Mir-339_microRNA_precursor_family
Deaths in March 2022Deaths in March 2022
... complications from polycythemia vera. Mun Jong-nam, North Korean diplomat, ambassador to Italy (2017) and Syria (since 2018), ... Vatsala Deshmukh, 92, Indian actress (Toofan Aur Deeya, Ladki Sahyadri Ki, Jal Bin Machhli Nritya Bin Bijli). Vera Gissing, 93 ... Vera Gissing, one of Winton' children, has died aged 93 Retired Supreme Court Justice Eliezer Goldberg has passed away Умер ...
https://en.wikipedia.org/wiki/Deaths_in_March_2022
Acute megakaryoblastic leukemiaAcute megakaryoblastic leukemia
... polycythemia vera, essential thrombocytosis, and primary myelofibrosis. In one review of adult-AMKL, 25% of 49 cases were ... polycythemia vera, essential thrombocytosis, primary myelofibrosis, or mediastinal germ cell tumor. AMKL associated with ...
https://en.wikipedia.org/wiki/Acute_megakaryoblastic_leukemia
Malar flushMalar flush
It can also be associated with lupus, polycythemia vera and homocystinuria. Malar flush is a plum-red discolouration of the ... It can also be associated with other conditions, such as lupus, polycythemia vera and homocystinuria. Malar rash Topol, Eric J ...
https://en.wikipedia.org/wiki/Malar_flush
RanimustineRanimustine
December 1988). "[Therapeutic effect of ranimustine (MCNU) on essential thrombocythemia and polycythemia vera]". Gan To Kagaku ... is a nitrosourea alkylating agent approved in Japan for the treatment of chronic myelogenous leukemia and polycythemia vera. It ...
https://en.wikipedia.org/wiki/Ranimustine
Primary myelofibrosisPrimary myelofibrosis
... can begin with a blood picture similar to that found in polycythemia vera or chronic myeloid leukemia. ... Najean Y, Rain JD (November 1997). "Treatment of polycythemia vera: the use of hydroxyurea and pipobroman in 292 patients under ... November 2010). "Oxidative stress is increased in primary and post-polycythemia vera myelofibrosis". Experimental Hematology. ... such as polycythemia vera, and less commonly, essential thrombocythemia. In these cases, myelofibrosis occurs as a result of ...
https://en.wikipedia.org/wiki/Primary_myelofibrosis
HemorheologyHemorheology
Tefferi A (May 2003). "A contemporary approach to the diagnosis and management of polycythemia vera". Curr. Hematol. Rep. 2 (3 ... When the hematocrit rises to 60 or 70%, which it often does in polycythemia, the blood viscosity can become as great as 10 ...
https://en.wikipedia.org/wiki/Hemorheology
Capillary leak syndromeCapillary leak syndrome
It is often misdiagnosed as polycythemia, polycythemia vera, hyperviscosity syndrome, or sepsis. Most SCLS patients succumb to ...
https://en.wikipedia.org/wiki/Capillary_leak_syndrome
CD177CD177
Pahl HL (2003). "PRV-1 mRNA expression and other molecular markers in polycythemia rubra vera". Curr. Hematol. Rep. 2 (3): 231- ... 2003). "Fluorescence in situ hybridization analysis of the PRV-1 gene in polycythemia vera: implications for its role in ... 2002). "Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia". J. Clin. Oncol. 20 (20): 4249-54. ... which is overexpressed in polycythemia rubra vera". Blood. 95 (8): 2569-76. doi:10.1182/blood.V95.8.2569. PMID 10753836. ...
https://en.wikipedia.org/wiki/CD177
Iron-deficiency anemiaIron-deficiency anemia
Two examples of bleeding disorders are von Willebrand disease and polycythemia vera. The body normally gets the iron it ...
https://en.wikipedia.org/wiki/Iron-deficiency_anemia
ThrombocythemiaThrombocythemia
High platelet counts can occur in patients with polycythemia vera (high red blood cell counts), and is an additional risk ... These include: essential thrombocythemia, chronic myelogenous leukemia, polycythemia vera, and primary myelofibrosis. Extremely ...
https://en.wikipedia.org/wiki/Thrombocythemia
Janus kinase 2Janus kinase 2
Jak2 mutation, when demonstrable, is one of the methods of diagnosing polycythemia vera. Janus kinase 2 has been shown to ... Pargade V, Darnige L, Gaussem P (2006). "[Acquired mutation of JAK2 tyrosine kinase and polycythaemia vera]". Annales de ... Mutations in JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other ...
https://en.wikipedia.org/wiki/Janus_kinase_2
Tet methylcytosine dioxygenase 2Tet methylcytosine dioxygenase 2
May 2009). "TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis". ...
https://en.wikipedia.org/wiki/Tet_methylcytosine_dioxygenase_2
Amaurosis fugaxAmaurosis fugax
"Peripheral arterial occlusion and amaurosis fugax as the first manifestation of polycythemia vera. A case report". Blut. 48 (3 ... Systemic lupus erythematosus Periarteritis nodosa Eosinophilic vasculitis Hyperviscosity syndrome Polycythemia ...
https://en.wikipedia.org/wiki/Amaurosis_fugax
Boogie2988Boogie2988
But I got my official diagnosis today so why not? I do in fact have a type of blood cancer called Polycythemia Vera. It's ... In November 2022, Williams was diagnosed with polycythemia vera, a type of blood cancer. In September 2020, Boogie began ...
https://en.wikipedia.org/wiki/Boogie2988
Erythropoietin receptorErythropoietin receptor
Mutations in Jak2 kinases associated with EpoR can also lead to polycythemia vera. Primary role of EpoR is to promote ... "A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera". Nature. 434 (7037): 1144-8. ...
https://en.wikipedia.org/wiki/Erythropoietin_receptor
Allen C EavesAllen C Eaves
Unregulated proliferation of primitive neoplastic progenitor cells in long-term polycythemia vera marrow cultures. J Clin ... dose-response curves for three classes of erythroid progenitors in normal and in patients with polycythemia vera. Blood 52: ... Hematopoietic stem cells Cellular therapy Bone marrow transplantation Chronic myelogenous leukemia Polycythemia vera Terry Fox ...
https://en.wikipedia.org/wiki/Allen_C_Eaves
OncovirusOncovirus
Production of leukemia and polycythemia vera by means of cancerous nucleoproteins from tissue cultures". Medicina ...
https://en.wikipedia.org/wiki/Oncovirus
Clonal hypereosinophiliaClonal hypereosinophilia
Patients with the polycythemia vera form of the disease have been treated by reducing the circulating red blood cell load by ... polycythemia vera; three cases resembled acute myelogenous leukemia; and one case presented with findings of a combined ... with ETV6-ACSL6 gene fusion in polycythemia vera". Leukemia. 20 (6): 1175-8. doi:10.1038/sj.leu.2404194. PMID 16572202. ...
https://en.wikipedia.org/wiki/Clonal_hypereosinophilia
Will SelfWill Self
Self was diagnosed with the blood disease Polycythaemia vera in 2011. He has described himself as a psychogeographer and modern ...
https://en.wikipedia.org/wiki/Will_Self
ACSL6ACSL6
2006). "t(5;12)(q23-31;p13) with ETV6-ACSL6 gene fusion in polycythemia vera". Leukemia. 20 (6): 1175-8. doi:10.1038/sj.leu. ...
https://en.wikipedia.org/wiki/ACSL6
HydroxycarbamideHydroxycarbamide
... polycythemia vera, and cervical cancer. In sickle-cell disease it increases fetal hemoglobin and decreases the number of ... primarily essential thrombocythemia and polycythemia vera). It has been found to be superior to anagrelide for the control of ...
https://en.wikipedia.org/wiki/Hydroxycarbamide
RuxolitinibRuxolitinib
In polycythaemia vera, the most common side effects include anemia (low red blood cell counts) and thrombocytopenia (low blood ... It is also indicated for the treatment of adults with polycythaemia vera who are resistant to or intolerant of hydroxyurea. ... In 2014, it was approved in polycythemia vera (PCV) when there has been an inadequate response to or intolerance of hydroxyurea ... January 2015). "Ruxolitinib versus standard therapy for the treatment of polycythemia vera". The New England Journal of ...
https://en.wikipedia.org/wiki/Ruxolitinib
BloodBlood
Non-cancerous overproduction of red cells (polycythemia vera) or platelets (essential thrombocytosis) may be premalignant. ... including hemochromatosis and polycythemia. However, bloodletting and leeching were common unvalidated interventions used until ...
https://en.wikipedia.org/wiki/Blood
Chet LemonChet Lemon
In the spring of 1990, Lemon was diagnosed with polycythemia vera, a rare blood disorder. During the 1990 season, he missed 47 ...
https://en.wikipedia.org/wiki/Chet_Lemon
Alkaline phosphataseAlkaline phosphatase
... such as polycythemia vera, essential thrombocytosis, and in primary myelofibrosis. Lower than typical levels are found in ...
https://en.wikipedia.org/wiki/Alkaline_phosphatase
SpleenSpleen
It may be caused by sickle cell anemia, sarcoidosis, malaria, bacterial endocarditis, leukemia, polycythemia vera, pernicious ...
https://en.wikipedia.org/wiki/Spleen
The Talmud: The Steinsaltz EditionThe Talmud: The Steinsaltz Edition
... such as identifying Ursa Major as a star and describing polycythemia vera as a disease causing excessive bleeding from the gums ...
https://en.wikipedia.org/wiki/The_Talmud:_The_Steinsaltz_Edition
2022 in British radio2022 in British radio
Boom Radio presenter David Hamilton reveals on air that he has been diagnosed with polycythaemia vera, a rare form of blood ...
https://en.wikipedia.org/wiki/2022_in_British_radio
MegakaryocyteMegakaryocyte
... major thrombosis and bleeding complications in essential thrombocythaemia and polycythaemia vera". Platelets. 15 (2): 67-84. ...
https://en.wikipedia.org/wiki/Megakaryocyte
ApheresisApheresis
... with symptoms from extreme elevations in platelet count such as those with essential thrombocythemia or polycythemia vera. In ...
https://en.wikipedia.org/wiki/Apheresis
List of skin conditionsList of skin conditions
Polycythemia vera (erythremia) Primary cutaneous follicular lymphoma (follicular center cell lymphoma, follicular center ...
https://en.wikipedia.org/wiki/List_of_skin_conditions
Mosquito bite allergyMosquito bite allergy
... polycythemia vera, chronic myeloid leukemia, chronic lymphocytic leukemia, Hodgkin lymphoma, nasopharyngeal cancer, and renal ...
https://en.wikipedia.org/wiki/Mosquito_bite_allergy
MinnaramMinnaram
Romy, that she shares the same deadly illness as her sister, polycythemia vera. He worries that she must have accidentally ...
https://en.wikipedia.org/wiki/Minnaram
William VainchenkerWilliam Vainchenker
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera », Nature, 2005 apr 28;434(7037), p ... erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera », ...
https://en.wikipedia.org/wiki/William_Vainchenker
Ron MilesRon Miles
He was 58, and suffered from polycythemia vera - a rare blood cancer - prior to his death. Distance for Safety (Prolific, 1987 ...
https://en.wikipedia.org/wiki/Ron_Miles
Adin SteinsaltzAdin Steinsaltz
... such as identifying Ursa Major as a star and describing polycythemia vera as a disease causing excessive bleeding from the gums ...
https://en.wikipedia.org/wiki/Adin_Steinsaltz
ErythromelalgiaErythromelalgia
... polycythemia vera, essential thrombocytosis, hypercholesterolemia, mushroom or mercury poisoning, and some autoimmune disorders ...
https://en.wikipedia.org/wiki/Erythromelalgia
Igor StravinskyIgor Stravinsky
Vera de Bosset Sudeikina (Vera Stravinsky) profile at bbc.co.uk Archived 10 April 2008 at the Wayback Machine. Retrieved 3 ... His case of polycythemia had worsened and his friends had noticed that his movements and speech had slowed. In 1965, Stravinsky ... Stravinsky met Vera de Bosset in Paris in February 1921, while she was married to the painter and stage designer Serge Sudeikin ... Vera arrived in January 1940 and the couple married on 9 March in Bedford, Massachusetts. After a period of travel, the two ...
https://en.wikipedia.org/wiki/Igor_Stravinsky
LestaurtinibLestaurtinib
These include a multi-center Phase II trial involving 37 patients with V617F JAK2 positive polycythemia vera and essential ... January 2014). "Open-label study of oral CEP-701 (lestaurtinib) in patients with polycythaemia vera or essential ... V617F JAK2 positive polycythemia vera and essential thrombocytosis, and refractory neuroblastoma. The most significant effort ...
https://en.wikipedia.org/wiki/Lestaurtinib
Chronic myelogenous leukemiaChronic myelogenous leukemia
August 2007). "Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera ...
https://en.wikipedia.org/wiki/Chronic_myelogenous_leukemia
Janus kinase inhibitorJanus kinase inhibitor
"Momelotinib in Transfusion-Dependent Adults with Primary Myelofibrosis (PMF) or Post-polycythemia Vera or Post-essential ...
https://en.wikipedia.org/wiki/Janus_kinase_inhibitor
Histone deacetylase inhibitorHistone deacetylase inhibitor
Givinostat (ITF2357) is also under investigation for treatment of polycythemia vera (PV), essential thrombocythemia (ET) and ...
https://en.wikipedia.org/wiki/Histone_deacetylase_inhibitor
Medical genetics of JewsMedical genetics of Jews
Kaposi's sarcoma Maple syrup urine disease Mucolipidosis IV Myeloproliferative neoplasms including polycythemia vera and ...
https://en.wikipedia.org/wiki/Medical_genetics_of_Jews
Facies (medical)Facies (medical)
Cushing's syndrome and polycythemia vera Bird facies - Pierre Robin sequence Ashen grey facies - myocardial infarction Gargoyle ...
https://en.wikipedia.org/wiki/Facies_(medical)
ChlorambucilChlorambucil
It can be used for treating some types of non-Hodgkin lymphoma, Waldenström macroglobulinemia, polycythemia vera, trophoblastic ...
https://en.wikipedia.org/wiki/Chlorambucil
ChoreaChorea
... polycythaemia rubra vera, transmissible spongiform encephalopathies, coeliac disease and gluten ataxia. There is no standard ...
https://en.wikipedia.org/wiki/Chorea
Myelophthisic anemiaMyelophthisic anemia
... especially late-stage or spent polycythemia vera), granulomatous diseases, and (lipid) storage diseases. Myelofibrosis can ...
https://en.wikipedia.org/wiki/Myelophthisic_anemia
Polycythemia Vera - Polycythemia Vera | NHLBI, NIHPolycythemia Vera - Polycythemia Vera | NHLBI, NIH
Polycythemia vera is a rare blood cancer that affects the bone marrow and causes the body to make too many red blood cells, ... The definition of polycythemia vera has changed in recent years. Once considered a blood disorder only, polycythemia vera is ... You can also find patient information on polycythemia vera on the National Center for Advancing Translational Sciences website ... For more detailed information on polycythemia vera, the National Cancer Institute provides patient information on its Chronic ...
https://www.nhlbi.nih.gov/health/polycythemia-vera
Polycythemia Vera Differential DiagnosesPolycythemia Vera Differential Diagnoses
Polycythemia vera (PV) is a stem cell disorder characterized as a panhyperplastic, malignant, and neoplastic marrow disorder. ... Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols. Semin Hematol. 1986 Apr. 23( ... The diagnosis and management of polycythemia vera in the era since the Polycythemia Vera Study Group: a survey of American ... encoded search term (Polycythemia Vera) and Polycythemia Vera What to Read Next on Medscape ...
https://www.medscape.com/answers/205114-103558/what-are-the-differential-diagnoses-for-polycythemia-vera
Polycythemia vera: MedlinePlus GeneticsPolycythemia vera: MedlinePlus Genetics
Polycythemia vera is a condition characterized by an increased number of red blood cells in the bloodstream. Explore symptoms, ... polycythemia vera has been found to run in families. In some of these families, the risk of developing polycythemia vera ... medlineplus.gov/genetics/condition/polycythemia-vera/ Polycythemia vera. ... Individuals with polycythemia vera have an increased risk of deep vein thrombosis. (DVT), a type of blood clot that occurs in ...
https://medlineplus.gov/genetics/condition/polycythemia-vera
What is polycythemia vera (PV)?What is polycythemia vera (PV)?
Polycythemia vera (PV) is a stem cell disorder characterized as a panhyperplastic, malignant, and neoplastic marrow disorder. ... Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols. Semin Hematol. 1986 Apr. 23( ... The diagnosis and management of polycythemia vera in the era since the Polycythemia Vera Study Group: a survey of American ... From efficacy to safety: a Polycythemia Vera Study Group report on hydroxyurea in patients with polycythemia vera. Semin ...
https://www.medscape.com/answers/205114-102515/what-is-polycythemia-vera-pv
ATSDR - Polycythemia Vera InvestigationATSDR - Polycythemia Vera Investigation
Update - Polycythemia Vera Research in Pennsylvania-Schuylkill, Luzerne, and Carbon Counties (September 2012) Cdc-pdf. [PDF - ... Determination of accuracy of Polycythemia Vera diagnoses and use of the JAK2V617F test in the diagnostic scheme Cdc-pdf. [PDF ... Updated and expanded study of polycythemia vera and other myeloproliferative neoplasms in the tri-county area Cdc-pdf. [PDF - ... Fact sheet: Geographic study of polycythemia vera occurrence in central Pennsylvania (2001-2007) Cdc-pdf. [PDF - 105 KB] ...
https://www.atsdr.cdc.gov/sites/polycythemia_vera/
Polycythemia Vera Differential DiagnosesPolycythemia Vera Differential Diagnoses
Polycythemia vera (PV) is a stem cell disorder characterized as a panhyperplastic, malignant, and neoplastic marrow disorder. ... Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols. Semin Hematol. 1986 Apr. 23( ... The diagnosis and management of polycythemia vera in the era since the Polycythemia Vera Study Group: a survey of American ... encoded search term (Polycythemia Vera) and Polycythemia Vera What to Read Next on Medscape ...
https://emedicine.medscape.com/article/205114-differential
Polycythemia vera - Symptoms and causes - Mayo ClinicPolycythemia vera - Symptoms and causes - Mayo Clinic
Polycythemia vera (adult). Mayo Clinic. 2019.. *Cuthbert D, et al. Polycythemia vera-associated complications: Pathogenesis, ... Polycythemia vera. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/polycythemia-vera. ... Polycythemia vera (pol-e-sy-THEE-me-uh VEER-uh) is a type of blood cancer. It causes your bone marrow to make too many red ... Polycythemia vera can occur at any age, but its more common in adults between 50 and 75. Men are more likely to get ...
https://www.mayoclinic.org/diseases-conditions/polycythemia-vera/symptoms-causes/syc-20355850
Polycythemia Rubra VeraPolycythemia Rubra Vera
Polycythaemia rubra vera, [M]Polycythaemia vera, [M]Polycythemia rubra vera, [M]Polycythemia vera, polycythemia vera, ... vera, rubra; polycythaemia rubra vera, vera; polycythaemia vera, polycythaemia vera, Erythremie, Polycythaemia vera, Vasquez- ... polycythemia; rubra vera, polycythemia; vera, rubra; polycythemia rubra vera, vera; polycythemia, Polycythemia vera -RETIRED-, ... polycythemia vera (diagnosis), Polycythaemia vera -RETIRED-, Primary polycythemia, Polycythemia Vera [Disease/Finding], Vera, ...
https://fpnotebook.com/HemeOnc/Marrow/PlycythmRbrVr.htm
Polycythemia Vera | Cancer Support CommunityPolycythemia Vera | Cancer Support Community
Polycythemia Vera Polycythemia vera (PV) is a rare type of blood cancer. PV is one of the 3 most common myeloproliferative ... The increase in red blood cells can cause the blood to thicken and clot, causing signs and symptoms of polycythemia vera. In ... Blood tests are used to diagnose polycythemia vera. Signs may include:. *An increase in red blood cells, platelets and white ... The various drugs used to treat polycythemia vera work in different ways, and may have different side effects. Ask for more ...
https://www.cancersupportcommunity.org/polycythemia-vera
Polycythemia Vera | VCA Animal HospitalsPolycythemia Vera | VCA Animal Hospitals
What is polycythemia vera, and what are the symptoms?. Polycythemia vera, or true polycythemia, is a rare disease of dogs and ... Some cases of polycythemia are secondary, or related to another disease.. What causes polycythemia?. Polycythemia can be ... If, however, secondary causes of polycythemia are absent, then the diagnosis is polycythemia vera (true or primary ... If left untreated, polycythemia vera can affect the heart. This disease can develop slowly over many months if it is a primary ...
https://vcahospitals.com/know-your-pet/polycythemia-vera
Polycythemia Vera - Health Library | NewYork-Presbyterian
This increases the risk for dangerous blood clots (thrombosis). The cause of polycythemia vera is a mutation in the blood... ... polycythemia) but also white blood cells and platelets. As numbers of blood cells rise, the blood becomes thicker. ... Polycythemia vera is an abnormal increase in blood cells, primarily red blood cells ( ...
https://www.nyp.org/healthlibrary/definitions/polycythemia-vera
Polycythemia vera - PubMedPolycythemia vera - PubMed
The diagnostic approach to a patient with polycythemia has been greatly simplified by the introduction of new genetic testing ... Polycythemia vera Raffaele Landolfi 1 , Maria Anna Nicolazzi, Angelo Porfidia, Leonardo Di Gennaro ... The treatment of polycythaemia vera: an update in the JAK2 era. Finazzi G, Barbui T. Finazzi G, et al. Intern Emerg Med. 2007 ... Hypercalcemia in a patient with polycythemia vera. Bae EH, Kim HS, Kim MJ, Kang YU, Kim YH, Kim CS, Choi JS, Ma SK, Kim SW. Bae ...
https://pubmed.ncbi.nlm.nih.gov/20237866
Polycythemia Vera | SCUBADOC - Diving Medicine OnlinePolycythemia Vera | SCUBADOC - Diving Medicine Online
What is Polycythemia?. It is a condition in which the body produces too many red blood cells. There are few references to this ... Treated polycythemia with near normal blood counts, a normal sized spleen and none of the side effects of medication should be ... Hydrea (hydroxyurea), a medication used to treat polycythemia, can cause some or all of the following side effects: Nausea, ...
http://scuba-doc.com/polycythemia-vera/
Fast Five Quiz: Polycythemia Vera (Transcript)Fast Five Quiz: Polycythemia Vera (Transcript)
Polycythemia vera is a stem cell disorder associated with bleeding complications. Do you know key information about ... Polycythemia vera (PV) is a stem cell disorder characterized as a panhyperplastic, malignant, and neoplastic marrow disorder. ... Fast Five Quiz: Are You Familiar With Key Aspects of Polycythemia Vera? - Medscape - Apr 04, 2018. ... Fast Five Quiz: Are You Familiar With Key Aspects of Polycythemia Vera? ...
https://reference.medscape.com/viewarticle/894719
Efficacious Intermittent Dosing of a Novel JAK2 Inhibitor in Mouse Models of Polycythemia Vera | PLOS ONEEfficacious Intermittent Dosing of a Novel JAK2 Inhibitor in Mouse Models of Polycythemia Vera | PLOS ONE
A high percentage of patients with the myeloproliferative disorder polycythemia vera (PV) harbor a Val617→Phe activating ... Polycythemia vera (PV) is a disease involving biology for which there is a rich history of study. The discovery of the JAKV617F ... 1. Ma X, Vanasse G, Cartmel B, Wang Y, Selinger HA (2008) Prevalence of polycythemia vera and essential thrombocythemia. Am J ... Polycythemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF) are all conditions that are classified ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037207
Study Confirms Treatment Target in Patients With Polycythemia VeraStudy Confirms Treatment Target in Patients With Polycythemia Vera
Patients with the rare form of blood cancer polycythemia vera whose hematocrit levels hover between 45% and 50% have a four- ... Known as the Cytoreductive Therapy in Polycythemia Vera-or Cyto-PV-trial and conducted at 21 centers in Italy, the study tested ... Patients with the rare form of blood cancer polycythemia vera whose hematocrit levels hover between 45% and 50% have a four- ... To prevent potentially fatal cardiovascular complications in patients with polycythemia vera (PV), hematocrit values should be ...
https://www.onclive.com/view/study-confirms-treatment-target-in-patients-with-polycythemia-vera
Dr. Verstovsek on Benefit of Ruxolitinib in Polycythemia VeraDr. Verstovsek on Benefit of Ruxolitinib in Polycythemia Vera
... discusses the benefit of ruxolitinib in polycythemia vera. ... Verstovsek on Benefit of Ruxolitinib in Polycythemia Vera. . ... in the treatment of patients with polycythemia vera (PV).. Not only has the JAK inhibitor ruxolitinib become the standard of ... discusses the benefit of ruxolitinib in polycythemia vera. ...
https://www.onclive.com/view/dr-verstovsek-on-benefit-of-ruxolitinib-in-polycythemia-vera
Polycythemia vera - About the Disease - Genetic and Rare Diseases Information CenterPolycythemia vera - About the Disease - Genetic and Rare Diseases Information Center
Find symptoms and other information about Polycythemia vera. ... Polycythemia vera. Other Names: PRV; PV; Polycythemia rubra ... vera; Primary polycythemiaPRV; PV; Polycythemia rubra vera; Primary polycythemia. Read More ... Polycythemia vera is a condition characterized by an increased number of red blood cells in the bloodstream (erythrocytosis). ... Currently GARD is able to provide the following information for Polycythemia vera:. *Population Estimate:In the US, there are ...
https://rarediseases.info.nih.gov/diseases/7422/polycythemia-vera
Ruxolitinib: A Targeted Treatment Option for Patients with Polycythemia Vera - Oncology Nurse AdvisorRuxolitinib: A Targeted Treatment Option for Patients with Polycythemia Vera - Oncology Nurse Advisor
This research provides a summary of the pathobiology of polycythemia vera and clinical data associated with ruxolitinib. ... Polycythemia vera is a chronic myeloproliferative neoplasm characterized by an increased red blood count and is known to be ... Ruxolitinib: A Targeted Treatment Option for Patients with Polycythemia Vera Kris Vaddi, Srdan Verstovsek, Jean-Jacques ... Polycythemia vera (PV) is a disorder predominantly characterized by erythrocytosis.1 As opposed to secondary erythrocytoses, PV ...
https://www.oncologynurseadvisor.com/home/cancer-types/leukemia/ruxolitinib-a-targeted-treatment-option-for-patients-with-polycythemia-vera/2/
LOW-PV interim analysis: Ropeginterferon versus phlebotomy in low-risk polycythemia vera - ecancerLOW-PV interim analysis: Ropeginterferon versus phlebotomy in low-risk polycythemia vera - ecancer
The question of my study was to see whether patients at low risk of thrombosis with a polycythemia vera can benefit from ... So we concluded that also in low risk patients with polycythemia vera the addition to standard therapy of ropeginterferon can ... LOW-PV interim analysis: Ropeginterferon versus phlebotomy in low-risk polycythemia vera. ... which is comparing ropeginterferon versus phlebotomy in low-risk patients with polycythemia vera.. Prof Barbui concludes that ...
https://ecancer.org/en/video/9092-low-pv-interim-analysis-ropeginterferon-versus-phlebotomy-in-low-risk-polycythemia-vera
Polycythemia Vera Flashcards by Rachel Martin | BrainscapePolycythemia Vera Flashcards by Rachel Martin | Brainscape
Study Polycythemia Vera flashcards from Rachel Martin's class online, or in Brainscape's iPhone or Android app. ✓ Learn ... Increase in megakaryocytes AND erythroid precursors...(some overla in pathogenesis of P. vera and ET, but not understood). -- ...
https://www.brainscape.com/flashcards/polycythemia-vera-704772/packs/1332039
Signs, Symptoms, and Complications of Polycythemia Vera | Hematology-Oncology Associates of CNYSigns, Symptoms, and Complications of Polycythemia Vera | Hematology-Oncology Associates of CNY
Polycythemia vera (PV) develops slowly. The disease may not cause signs or symptoms for years. When signs and symptoms are ... Signs, Symptoms, and Complications of Polycythemia Vera. Polycythemia vera (PV) develops slowly. The disease may not cause ... Polycythemia Vera Complications. If you have PV, the thickness of your blood and the slowed blood flow can cause serious health ... Polycythemia Vera*Other Names for Polycythemia Vera?. *What Causes Polycythemia Vera?. *Risk Factors of Polycythemia Vera ...
https://www.hoacny.com/patient-resources/blood-disorders/what-polycythemia-vera/signs-symptoms-and-complications
Treatment of polycythemia vera with hydroxyurea - PubMedTreatment of polycythemia vera with hydroxyurea - PubMed
Thirty-six patients with polycythemia vera were treated with hydroxyurea for 12 to 67 months. Nineteen patients were previously ... Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols. Berk PD, Goldberg JD, ... Treatment of polycythemia vera with hydroxyurea R Sharon et al. Cancer. 1986. . ... Anesthesia for polycythemia vera. Sosis MB. Sosis MB. J Clin Anesth. 1990 Jan-Feb;2(1):31-4. doi: 10.1016/0952-8180(90)90046-6. ...
https://www.ncbi.nlm.nih.gov/pubmed/3943010
A Multidisciplinary Investigation of a Polycythemia Vera Cancer Cluster of Unknown OriginA Multidisciplinary Investigation of a Polycythemia Vera Cancer Cluster of Unknown Origin
Determination of accuracy of polycythemia vera diagnoses and use of the JAK2V617F test in the diagnostic scheme Cite ... In 2008, a cluster of polycythemia vera, a rare blood cancer with unknown etiology, was identified in northeast Pennsylvania. A ... Title : Determination of accuracy of polycythemia vera diagnoses and use of the JAK2V617F test in the diagnostic scheme ... Title : A Multidisciplinary Investigation of a Polycythemia Vera Cancer Cluster of Unknown Origin Personal Author(s) : Seaman, ...
https://stacks.cdc.gov/view/cdc/4014
Case of polycythemia vera concurrent with FIP1L1-PDGFRA-positive myeloproliferative neoplasm with eosinophilia - Cancer Genetics
Phase II open label trial of imatinib in polycythemia rubra vera.. Int J Hematol. 2008; 88: 489-494. View in Article *Scopus (5 ... JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis.. N Engl J Med. 2007; 356: 459-468. View in Article * ... Imatinib effect on growth and signal transduction in polycythemia vera.. Exp Hematol. 2007; 35: 931-938. View in Article * ... Hypereosinophilic syndrome associated with polycythemia vera.. Arch Intern Med. 1986; 146: 1440-1441. View in Article *Scopus ( ...
https://www.cancergeneticsjournal.org/article/S2210-7762
Is polycythemia vera related to cancer?Is polycythemia vera related to cancer?
Polycythemia vera is not exactly cancer. It comes under the group of diseases called myeloproliferative disorders. Basically, ... iCliniq / Answers / Internal Medicine / Polycythemia Vera / Is polycythemia vera related to cancer? ... a detailed search for secondary causes should be done before labeling diagnosis as polycythemia vera or primary polycythemia. ... I am a female, 50 years old and want to know whether polycythemia vera is related to cancer or not. I have taken JAK2 mutation ...
https://www.icliniq.com/qa/polycythemia-vera/can-polycythemia-vera-be-related-to-cancer
Polycythemia Vera with High Erythropoietin Level: Case ReportPolycythemia Vera with High Erythropoietin Level: Case Report
... Rami Nassabein1*, Mariam al khatib2, Marie Helen Abbas3, Marie ... 2016) Polycythemia Vera with High Erythropoietin Level: Case Report. Int J Blood Res Disord 3:023. doi.org/10.23937/2469-5696/ ... Polycythemia vera, Erythropoietin, Budd-Chiari syndrome Introduction. In the presence of symptoms, Erythrocytosis, warrants ... Patient was diagnosed with Budd-Chiari syndrome due to Polycythemia Vera on top of chronic liver disease. He was put on aspirin ...
https://clinmedjournals.org/articles/ijbrd/international-journal-of-blood-research-and-disorders-ijbrd-3-023.php
Patterns of presentation and thrombosis outcome in patients with polycythemia vera strictly defined by WHO-criteria and...
Most studies in polycythemia vera (PV) include patients with both remote and most recent diagnostic periods and are therefore ... N2 - Most studies in polycythemia vera (PV) include patients with both remote and most recent diagnostic periods and are ... AB - Most studies in polycythemia vera (PV) include patients with both remote and most recent diagnostic periods and are ... abstract = "Most studies in polycythemia vera (PV) include patients with both remote and most recent diagnostic periods and are ...
https://mayoclinic.pure.elsevier.com/en/publications/patterns-of-presentation-and-thrombosis-outcome-in-patients-with-
PVJAK - Overview: Polycythemia Vera, JAK2 V617F with Reflex to JAK2 Exon 12-15, Sequencing for Erythrocytosis, VariesPVJAK - Overview: Polycythemia Vera, JAK2 V617F with Reflex to JAK2 Exon 12-15, Sequencing for Erythrocytosis, Varies
A positive mutation status is highly suggestive of a myeloid neoplasm and may support a diagnosis of polycythemia vera in the ... Polycythemia Vera, JAK2 V617F with Reflex to JAK2 Exon 12-15, Sequencing for Erythrocytosis, Varies. ... A negative mutation status makes a diagnosis of polycythemia vera highly unlikely, although it does not completely exclude this ... If this test is ordered in the setting of erythrocytosis and suspicion of polycythemia vera, interpretation requires ...
https://www.mayocliniclabs.com/test-catalog/overview/65116
MyelofibrosisNeoplasmsMutationCourse of polycythemia veraPeople with polycythemia veraManagement of polycythemia veraPatientsEssentialTreat Polycythemia VeraJAK2Development of polycythemiaThrombocytosisDiagnosisSecondaryChronicInterferonComplicationsJakafiFamilialDisorderSymptomsMyeloidErythrocytosisPrimaryPolicitemia Vera2022OxygenBoneATSDRHypertension2017ClinicalHemoglobinTherapeuticsDiseaseGeneticPatientBloodStem cell
Myelofibrosis16
  • In a case study published in Case Reports in Hematology , investigators report on the first known case of DM associated with secondary myelofibrosis (MF) following polycythemia vera (PV) . (oncologynurseadvisor.com)
  • There are three main types of MPN: essential thrombocythemia (ET), myelofibrosis (MF) and polycythemia vera (PV). (silence-therapeutics.com)
  • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. (medscape.com)
  • JAK2V617F mutational status and allele burden have little influence on clinical phenotype and prognosis in patients with post-polycythemia vera and post-essential thrombocythemia myelofibrosis. (medscape.com)
  • Find financial assistance programs available for myelofibrosis/polycythemia vera drugs . (conquer-magazine.com)
  • Inrebic is a kinase inhibitor oral medication used for the treatment of adults with intermediate-2 or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis, a type of chronic blood cancer. (conquer-magazine.com)
  • Jakafi is a kinase inhibitor used for the treatment of patients with intermediate- or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis, and post-essential thrombocythemia myelofibrosis. (conquer-magazine.com)
  • Myelofibrosis, polycythemia vera, and essential thrombocythemia are 3 types of myeloproliferative neoplasms (or MPNs), which are rare and chronic blood cancers and have only a few approved treatments. (conquer-magazine.com)
  • MPN Research Foundation has a single goal: to stimulate original research in pursuit of new treatments - and eventually a cure - for polycythemia vera, essential thrombocythemia, and myelofibrosis, known collectively as myeloproliferative neoplasms (MPNs). (mpnresearchfoundation.org)
  • Post-polycythemia vera myelofibrosis (post-PV MF) is a critical hematologic evolution of polycythemia vera (PV). (uthscsa.edu)
  • While the exact cause is unknown, scientists believe that mutations, or changes in certain genes, are thought to be a major cause of what are known as Philadelphia chromosome-negative MPNs, or "classical" MPNs, including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF). (voicesofmpn.com)
  • The JAK2 V617F is present in 95% to 98% of polycythemia vera (PV), and 50% to 60% of primary myelofibrosis (PMF) and essential thrombocythemia (ET). (marshfieldlabs.org)
  • 5 . MPD (myeloproliferative diseases): JAK 2 mutation is now almost mandatory for diagnosis of polycythemia vera, and very useful for diagnosis of myelofibrosis and essential thrombocytosis. (shyamhemoncclinic.com)
  • polycythemia vera, essential thrombocythemia, and primary myelofibrosis, known as classical negative myeloproliferative neoplasms BCR-ABL1 (or Philadelphia chromosome). (bvsalud.org)
  • They recently concluded a study which used two major insurance claims databases to identify nearly 300,000 people with essential thrombocythemia, myelofibrosis, and polycythemia vera in the United States. (mpnfoundation.org)
  • In particular, overactive JAK signalling is linked to the development of cancer-like conditions called myeloproliferative neoplasms (MPNs) - which include polycythemia vera, essential thrombocythemia and primary myelofibrosis - as well as certain acute childhood leukaemias . (edu.au)
Neoplasms3
  • Polycythemia Vera (PV) is one of a group of rare conditions called myeloproliferative neoplasms (MPNs). (silence-therapeutics.com)
  • Attending a learning event designed specifically for patients with myeloproliferative neoplasms (MPNs) like polycythemia vera (PV) can be an informative and empowering experience. (jakafi.com)
  • abstract = "In this cross-sectional study of 45 patients with myeloproliferative neoplasms, we found no evidence of secondary osteoporosis.INTRODUCTION: Patients with essential thrombocythemia (ET) and polycythaemia vera (PV) are at increased risk of fractures but the underlying mechanisms have not been settled. (sdu.dk)
Mutation7
  • JAK2 gene mutations seem to be particularly important for the development of polycythemia vera, as nearly all affected individuals have a mutation in this gene. (medlineplus.gov)
  • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. (medscape.com)
  • JAK2V617F mutation and spontaneous megakaryocytic or erythroid colony formation in patients with essential thrombocythaemia (ET) or polycythaemia vera (PV). (medscape.com)
  • Polycythemia vera is not initiated by JAK2V617F mutation. (medscape.com)
  • Polycythemia vera occurs when a mutation in a gene causes a problem with blood cell production. (largestcharities.com)
  • In polycythemia vera, a mutation occurs in a bone marrow cell, resulting in overproduction of the bone marrow cells. (shoppersdrugmart.ca)
  • Although the exact cause of polycythemia vera is unknown, researchers have found that a specific gene mutation in the JAK2 gene is present in over 90% of cases. (shoppersdrugmart.ca)
Course of polycythemia vera2
  • I. To understand effects of continuous positive airway pressure (CPAP) for obstructive sleep apnea (OSA) on the course of polycythemia vera/essential thrombocythemia (PV/ET). (centerwatch.com)
  • We here present a case of repeat ESI due to Pseudomonas aeruginosa in a PD patient with skin changes in the course of polycythemia vera (PV). (biomedcentral.com)
People with polycythemia vera4
  • Some people with polycythemia vera experience headaches, dizziness, ringing in the ears (tinnitus), impaired vision, or itchy skin. (medlineplus.gov)
  • Although mutations in the TET2 gene have been found in approximately 16 percent of people with polycythemia vera, it is unclear what role these mutations play in the development of the condition. (medlineplus.gov)
  • Most people with polycythemia vera do not have a family history of this disease. (largestcharities.com)
  • In people with polycythemia vera , the bone marrow produces too many blood cells. (largestcharities.com)
Management of polycythemia vera2
  • The diagnosis and management of polycythemia vera in the era since the Polycythemia Vera Study Group: a survey of American Society of Hematology members' practice patterns. (medscape.com)
  • Vannucchi AM. From leeches to personalized medicine: evolving concepts in the management of polycythemia vera. (medscape.com)
Patients19
  • The bone marrow of patients with polycythemia vera (PV),contains normal stem cells but also contains abnormal clonal stem cells that interfere with or suppress normal stem cell growth and maturation. (medscape.com)
  • Median survival in patients with polycythemia vera (PV), which is 1.5-3 years in the absence of therapy, has been extended to approximately 14 years overall, and to 24 years for patients younger than 60 years of age, because of new therapeutic tools. (medscape.com)
  • This early phase I trial studies how well the use of a continuous positive airway pressure (CPAP) machine works in treating obstructive sleep apnea in patients with polycythemia vera or essential thrombocythemia. (centerwatch.com)
  • Obstructive sleep apnea is a condition where a person stops breathing during sleep, and is estimated to affect 30 to 50 percent of patients with polycythemia vera or essential thrombocythemia. (centerwatch.com)
  • Arterial (AT) and venous (VT) thrombotic events are the most common complications in patients with polycythemia vera (PV) and are the leading causes of morbidity and mortality. (elsevier.com)
  • Rusak T, Ciborowski M, Uchimiak-Owieczko A, Piszcz J, Radziwon P, Tomasiak M. Evaluation of hemostatic balance in blood from patients with polycythemia vera by means of thromboelastography: The effect of isovolemic erythrocytapheresis. (medscape.com)
  • INTRODUCTION: Patients with essential thrombocythemia (ET) and polycythaemia vera (PV) are at increased risk of fractures but the underlying mechanisms have not been settled. (sdu.dk)
  • Prescribed for most patients with polycythemia vera. (medscape.com)
  • Thrombocythemia and polycythemia in patients younger than 20 years at diagnosis: clinical and biologic features, treatment, and long-term outcome. (medscape.com)
  • Jakafi is also used for patients with polycythemia vera who cannot use or cannot benefit from treatment with hydroxyurea. (conquer-magazine.com)
  • Although essentially different in clinical presentation - patients with β-thalassemia have an impairment in β-globin synthesis leading to defective erythrocytes and anemia, while patients with Polycythemia vera present with high hemoglobin levels because of excessive red blood cell synthesis - both pathologies may characterized by lasting high erythropoietic activity, i.e. chronic stress erythropoiesis. (qxmd.com)
  • Real-world treatments and thrombotic events in polycythemia vera patients in the USA. (bvsalud.org)
  • Pharmacy Times® interviewed Brady Stein, MD, MHSc, of the Feinberg School of Medicine at Northwestern University, on the implications of the results of his research on further investigation and treatment opportunities for patients with polycythemia vera. (pharmacytimes.com)
  • Pharmacy Times® interviewed Brady Stein, MD, MHSc, of the Feinberg School of Medicine at Northwestern University, on the noteworthy results observed in the study in relation to cause of death among patients with polycythemia vera. (pharmacytimes.com)
  • Pharmacy Times® interviewed Brady Stein, MD, MHSc, of the Feinberg School of Medicine at Northwestern University, on the issues existing around prior data on the causes of death for patients with polycythemia vera (PV) and why it was important to have greater clarity in this area. (pharmacytimes.com)
  • Pharmacy Times® interviewed Brady Stein, MD, MHSc, of the Feinberg School of Medicine at Northwestern University, on the survival estimates for patients with polycythemia vera in the past and the mortality rates among these patients. (pharmacytimes.com)
  • Pharmacy Times® interviewed Brady Stein, MD, MHSc, of the Feinberg School of Medicine at Northwestern University, on what polycythemia vera (PV) is and why it was important to understand mortality and causes of death among patients with PV. (pharmacytimes.com)
  • Pegylated interferon α-2a (PEG-IFN-α-2a) has previously been shown to induce hematologic and molecular responses in patients with polycythemia vera (PV) or essential thrombocythemia (ET). (ashpublications.org)
  • Patients who have polycythemia vera with severe iron deficiency can exhibit leukocytosis and thrombocytosis. (medscape.com)
Essential2
  • Essential thrombocythemia and polycythemia vera: Focus on clinical practice. (mayoclinic.org)
  • The differential diagnosis of CML includes leukemoid reaction, myeloproliferative disorders , essential thrombocythemia , and polycythemia vera with iron deficiency. (medscape.com)
Treat Polycythemia Vera1
  • Alkylating agents and interferon also may be used to treat polycythemia vera. (consultant360.com)
JAK24
  • Mutations in the JAK2 and TET2 genes are associated with polycythemia vera. (medlineplus.gov)
  • Another type of polycythemia, called secondary polycythemia, isn't related to the JAK2 gene. (hoacny.com)
  • In polycythemia vera and ET, it has shown to have long term efficacy, and reduces JAK2 allelic burden. (medscape.com)
  • Las mutaciones somáticas en genes como JAK2, MPL y CARL se comportan como mutaciones drivers iniciadoras, responsables del fenotipo mieloproliferativo. (bvsalud.org)
Development of polycythemia1
  • Low blood oxygen levels ( hypoxia ) due to congenital heart disease also appear to be a factor in the development of polycythemia. (shoppersdrugmart.ca)
Thrombocytosis4
  • Can be used in addition to hydroxyurea for particularly difficult to control thrombocytosis in polycythemia vera. (medscape.com)
  • Are you an adult with polycythemia vera or thrombocytosis? (nih.gov)
  • This study aims to find a new treatment or cure for polycythemia vera and thrombocytosis by locating genes and their changes, or mutations, that may contribute to these disorders. (nih.gov)
  • To participate in this study, you must have polycythemia vera with elevated hemoglobin (higher than 18 in men and 16 in women) or thrombocytosis with an elevated platelet count (higher than 450,000). (nih.gov)
Diagnosis1
  • If the skin is flushed or itchy, particularly after a hot bath, it may indicate a diagnosis of polycythemia. (shoppersdrugmart.ca)
Secondary9
  • Long-term exposure to low oxygen levels causes secondary polycythemia. (hoacny.com)
  • People who have severe heart or lung disease may develop secondary polycythemia. (hoacny.com)
  • For example, working in an underground parking garage or living in a home with a poorly vented fireplace or furnace can raise your risk for secondary polycythemia. (hoacny.com)
  • Sometimes doctors can cure secondary polycythemia-it depends on whether the underlying cause can be stopped, controlled, or cured. (hoacny.com)
  • Erythrocytosis - Causes include secondary polycythemia (an increase in red blood cell [RBC] counts, typically due to chronic hypoxemia), familial erythrocythemia, and relative polycythemia (a benign condition in which RBC numbers are normal but plasma volume is contracted, due to dehydration or to reduced venous compliance). (medscape.com)
  • Secondary polycythemia affects some people as a result of limited oxygen due to smoking or living at high altitudes. (shoppersdrugmart.ca)
  • Secondary polycythemia is different from polycythemia vera in several ways. (shoppersdrugmart.ca)
  • Secondary polycythemia occurs when the body is not getting enough oxygen or as a response to certain drugs or hormones. (shoppersdrugmart.ca)
  • Additional tests will then be done to find out whether it is polycythemia vera or secondary polycythemia. (shoppersdrugmart.ca)
Chronic2
  • (7 days ago) Polycythemia vera is a rare, chronic disorder involving the overproduction of blood cells in the bone marrow (myeloproliferation). (healthzss.com)
  • In the course of his work with Chronic Myeloid Leukemia (CML) he began to study a related blood disease, polycythemia vera (PV). (mpnforum.com)
Interferon2
  • Interferon alfa: effects of long-term treatment for polycythemia vera. (medscape.com)
  • Recombinant interferon-alpha for treatment of polycythaemia vera. (medscape.com)
Complications2
  • Other complications of polycythemia vera include an enlarged spleen (splenomegaly), stomach ulcers, gout (a form of arthritis caused by a buildup of uric acid in the joints), heart disease, and cancer of blood-forming cells (leukemia). (medlineplus.gov)
  • The treatment of polycythemia vera is aimed at reducing the levels of red blood cells and preventing the complications of the disorder especially blood clot formation. (largestcharities.com)
Jakafi2
  • Jakafi is a prescription medicine used to treat adults with polycythemia vera who have already taken a medicine called hydroxyurea (HU) and it did not work well enough or they could not tolerate it. (jakafi.com)
  • Jakafi was originally created for Polycythemia Vera, a slow growing blood disorder. (askmeaboutmyhusbandscancer.com)
Familial1
  • Autosomal dominant inheritance means that one copy of an altered gene in each cell is sufficient to increase the risk of developing polycythemia vera, although the cause of this condition in familial cases is unknown. (medlineplus.gov)
Disorder7
  • Polycythemia vera (PV) is a stem cell disorder characterized as a panhyperplastic, malignant, and neoplastic marrow disorder. (medscape.com)
  • (Just Now) Polycythemia vera is a rare blood disorder in which there is an increase in all blood cells, particularly red blood cells. (healthzss.com)
  • (1 days ago) Polycythemia vera (PV) is a rare blood disorder in which the body makes too many red blood cells. (healthzss.com)
  • Polycythemia vera (PV) is a myeloproliferative disorder of unknown etiology. (revistanefrologia.com)
  • The myeloproliferative disorder, polycythemia vera, and the rare congenital polycythemias represent primary erythrocytosis. (hindawi.com)
  • Polycythemia vera (also called primary polycythemia ) is a rare growth disorder of the bone marrow, occurring when the marrow is overactive and produces more blood cells than the body needs. (shoppersdrugmart.ca)
  • Polycythemia vera is a primary bone marrow disorder. (shoppersdrugmart.ca)
Symptoms3
  • Many of the signs and symptoms of polycythemia vera are related to a shortage of oxygen in body tissues. (medlineplus.gov)
  • Polycythemia vera may be discovered through a blood count done for another reason, even before people have any symptoms. (largestcharities.com)
  • Polycythemia may not cause any symptoms. (shoppersdrugmart.ca)
Myeloid1
  • Polycythemia is characterized by increased cell counts in all cell lines in the myeloid series (ie, red blood cells, white blood cells [preferentially granulocytes], and platelets). (medscape.com)
Erythrocytosis1
  • If this test is ordered in the setting of erythrocytosis and suspicion of polycythemia vera, interpretation requires correlation with a concurrent or recent prior bone marrow evaluation. (marshfieldlabs.org)
Primary1
  • Polycythemia vera (PV) also is known as primary polycythemia. (hoacny.com)
Policitemia Vera1
  • la policitemia vera, la trombocitemia esencial y la mielofibrosis primaria, conocidas como neoplasias mieloproliferativas clásicas BCR-ABL1 (o cromosoma Philadelfia) negativas. (bvsalud.org)
20221
  • Polycythemia Vera Pipeline Insight, 2022 " report by DelveInsight outlines a comprehensive assessment of the present clinical/non-clinical development activities and growth prospects across the Polycythemia Vera Market. (sacramentonews-online.com)
Oxygen1
  • Living for long periods at high altitudes where there's less oxygen may lead to polycythemia. (shoppersdrugmart.ca)
Bone2
  • But in polycythemia vera, your bone marrow makes too many of some of these blood cells. (largestcharities.com)
  • Polycythemia vera, characterized by an abnormal proliferation of bone marrow elements-erythrocytes, leukocytes, and platelets-was diagnosed. (consultant360.com)
ATSDR2
  • The Agency for Toxic Substances and Disease Registry (ATSDR) will update community members on the polycythemia vera (PV) research projects in the tri-county area of Schuylkill, Luzerne, and Carbon Counties, PA on September 20, 2012 in Tamaqua, PA. (cdc.gov)
  • The federal Agency for Toxic Substances and Disease Registry (ATSDR) will hold a public meeting in the Tamaqua Area Auditorium at Tamaqua High School, 500 Penn St, Tamaqua, PA, on Saturday, October 24, 2009 from 10:00 to 11:30 a.m. to update area residents on recent efforts regarding polycythemia vera (PV). (cdc.gov)
Hypertension1
  • Group 5: Pulmonary hypertension caused by other diseases or conditions, including sarcoidosis, polycythemia vera (which can lead to increased blood viscosity and, subsequently, pulmonary hypertension), vasculitis, and other disorders. (medscape.com)
20172
  • EMA started the centralized marketing authorization procedure for Ropeginterferon alfa-2b for treatment of Polycythemia Vera (PV) on Feb 23rd 2017. (aop-health.com)
  • Vienna, March 14th 2017: AOP Orphan Pharmaceuticals AG (AOP Orphan) announced the start of the EMA marketing authorization application procedure (centralized procedure) for the European licensure of Ropeginterferon alfa-2b in Polycythemia Vera (PV) on Feb 23rd 2017. (aop-health.com)
Clinical4
  • Clinical and hematological presentation of children and adolescents with polycythemia vera. (medlineplus.gov)
  • Two clinical phenotypes in polycythemia vera. (medscape.com)
  • The Polycythemia Vera Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. (sacramentonews-online.com)
  • Currently, Protagonist Therapeutics has its Polycythemia Vera drug candidates in the most advanced stage of clinical development. (sacramentonews-online.com)
Hemoglobin2
  • In polycythemia vera used only to control platelet counts, but shows slight decrease in mean hemoglobin and hematocrit while white cell counts maintained. (medscape.com)
  • Polycythemia vera usually produces a high concentration of red blood cells or hemoglobin in the circulating blood, but it's important to note that white blood cell and platelet counts may also be increased. (shoppersdrugmart.ca)
Therapeutics1
  • Globally, more than 10+ key pharma and biotech companies are working on 10+ pipeline drugs in the Polycythemia Vera therapeutics landscape based on different Routes of Administration (RoA), Mechanism of Action (MoA), and molecule types. (sacramentonews-online.com)
Disease1
  • In these families, people seem to inherit an increased risk of polycythemia vera, not the disease itself. (medlineplus.gov)
Genetic1
  • β-Thalassemia and Polycythemia vera are genetic disorders which affect the synthesis of red blood cells, also referred to as erythropoiesis. (qxmd.com)
Patient5
  • Dr Phan Van Trung , who has more than 20 years of experience in the field of Internal Medicine, found the cause of the condition, discovering that the patient had polycythaemia vera. (fvhospital.com)
  • With consultation support from haematology specialists from the Hospital of Haematology and Blood Transfusion in HCM City, the patient underwent intensive tests to diagnose for polycythaemia vera. (fvhospital.com)
  • Here, we present a case of repeat ESI caused by Pseudomonas aeruginosa in a PD patient with polycythemia vera (PV). (biomedcentral.com)
  • Development of Focal Segmental Glomerulosclerosis in a Patient with Polycythemia Vera: can Polycythemia Vera be a cause of Focal Segmental Glomerulosclerosis? (revistanefrologia.com)
  • Tefferi A. Diagnostic approach to the patient with polycythemia. (mayoclinic.org)
Blood10
  • Polycythemia vera is a condition characterized by an increased number of red blood cells in the bloodstream. (medlineplus.gov)
  • (3 days ago) Polycythemia vera (pol-e-sy-THEE-me-uh VEER-uh) is a type of blood cancer. (healthzss.com)
  • (5 days ago) Polycythaemia vera is characterised by the production of too many red blood cells. (healthzss.com)
  • (7 days ago) Paterson New Jersey Hematologist Doctors physician directory - Polycythemia (high red blood cell count) is a condition in which the body's red blood cells are elevated. (healthzss.com)
  • Why can't you donate blood if you have polycythemia vera? (largestcharities.com)
  • Anemia, polycythemia, and white blood cells disorders. (mayoclinic.org)
  • The word polycythemia simply means "many cells in the blood. (shoppersdrugmart.ca)
  • Polycythemia is associated with an increased risk of blood clots (venous thrombosis, stroke, heart attack) and leukemia. (shoppersdrugmart.ca)
  • To reduce the risk of blood clots, treatment with low-dose acetylsalicylic acid* (ASA) is recommended for most people with polycythemia (unless there is a reason they should not take it). (shoppersdrugmart.ca)
  • PTG-300 is an injectable hepcidin mimetic in development for the treatment of polycythemia vera and other blood disorders. (pharmiweb.com)
Stem cell1
  • Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera. (medscape.com)