A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)
A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.
Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.
Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.
Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
A plant genus of the family FABACEAE.
The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)
Nanometer-sized, hollow, spherically-shaped objects that can be utilized to encapsulate small amounts of pharmaceuticals, enzymes, or other catalysts (Glossary of Biotechnology and Nanobiotechnology, 4th ed).
Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.
An excessive amount of fluid in the cornea due to damage of the epithelium or endothelium causing decreased visual acuity.
The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.
Relating to the size of solids.
Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.
A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics.
The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Salts that melt below 100 C. Their low VOLATILIZATION can be an advantage over volatile organic solvents.
A publication issued at stated, more or less regular, intervals.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
Respiratory syndrome characterized by the appearance of a new pulmonary infiltrate on chest x-ray, accompanied by symptoms of fever, cough, chest pain, tachypnea, or DYSPNEA, often seen in patients with SICKLE CELL ANEMIA. Multiple factors (e.g., infection, and pulmonary FAT EMBOLISM) may contribute to the development of the syndrome.
The portion of renal tubule that begins from the enlarged segment of the ascending limb of the LOOP OF HENLE. It reenters the KIDNEY CORTEX and forms the convoluted segments of the distal tubule.
Prevention of CONCEPTION by blocking fertility temporarily, or permanently (STERILIZATION, REPRODUCTIVE). Common means of reversible contraception include NATURAL FAMILY PLANNING METHODS; CONTRACEPTIVE AGENTS; or CONTRACEPTIVE DEVICES.
Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.
A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
An antimitotic agent with immunosuppressive properties.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
The privacy of information and its protection against unauthorized disclosure.
The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Sequential operating programs and data which instruct the functioning of a digital computer.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Production of drugs or biologicals which are unlikely to be manufactured by private industry unless special incentives are provided by others.
Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.
Laws concerned with manufacturing, dispensing, and marketing of drugs.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
Use of plants or herbs to treat diseases or to alleviate pain.
A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.

Interaction of tumor and normal blood cells with ethylene oxide and propylene oxide block copolymers. (1/274)

Ethylene oxide and propylene oxide block copolymers (pluronics) are widely known as agents that promote drug penetration across biological barriers. We have studied the interaction of normal and malignant blood cells with pluronics L61 and P85 that have different hydrophobicity. SP2/0 myeloma cells accumulated pluronics while normal cells adsorb most of the polymer on the surface. Interaction of pluronics with cells resulted in drastic changes of membrane microviscosity. Tumor cell membrane microviscosity decreased after pluronics adsorption, in contrast to normal cells, whose membrane microviscosity was enhanced. We suppose that sensitivity of tumor cell membrane microviscosity to the pluronics action correlates with its permeability for molecular substances.  (+info)

Assembly and secretion of chylomicrons by differentiated Caco-2 cells. Nascent triglycerides and preformed phospholipids are preferentially used for lipoprotein assembly. (2/274)

To develop a cell culture model for chyclomicron (CM) assembly, the apical media of differentiated Caco-2 cells were supplemented with oleic acid (OA) together with either albumin or taurocholate (TC). The basolateral media were subjected to sequential density gradient ultracentrifugations to obtain large CM, small CM, and very low density lipoproteins (VLDL), and the distribution of apoB in these fractions was quantified. In the absence of OA, apoB was secreted as VLDL/LDL size particles. Addition of OA (>/=0.8 mM) with TC, but not with albumin, resulted in the secretion of one-third of apoB as CM. Lipid analysis revealed that half of the secreted phospholipids (PL) and triglycerides (TG) were associated with CM. In CM, TG were 7-11-fold higher than PL indicating that CM were TG-rich particles. Secreted CM contained apoB100, apoB48, and other apolipoproteins. Secretion of large CM was specifically inhibited by Pluronic L81, a detergent known to inhibit CM secretion in animals. These studies demonstrate that differentiated Caco-2 cells assemble and secrete CM in a manner similar to enterocytes in vivo. Next, experiments were performed to identify the sources of lipids used for lipoprotein assembly. Cells were labeled with [3H]glycerol for 12 h, washed, and supplemented with OA, TC, and [14C] glycerol for various times to induce CM assembly and to radiolabel nascent lipids. TG and PL were extracted from cells and media and the association of preformed and nascent lipids with lipoproteins was determined. All the lipoproteins contained higher amounts of preformed PL compared with nascent PL. VLDL contained equal amounts of nascent and preformed TG, whereas CM contained higher amounts of nascent TG even when nascent TG constituted a small fraction of the total cellular pool. These studies indicate that nascent TG and preformed PL are preferentially used for CM assembly and provide a molecular explanation for the in vivo observations that the fatty acid composition of TG, but not PL, of secreted CM reflects the composition of dietary fat. It is proposed that in the intestinal cells the preformed PL from the endoplasmic reticulum bud off with apoB as primordial particles and the assembly of larger lipoproteins is dependent on the synthesis and delivery of nascent TG to these particles.  (+info)

Activities of poloxamer CRL-1072 against Mycobacterium avium in macrophage culture and in mice. (3/274)

Earlier studies reported that certain large hydrophobic poloxamer surfactants were able to inhibit the growth of Mycobacterium avium-M. intracellulare complex (MAI) in broth and to produce synergistic enhancement of the activity of rifampin. CRL-1072 was synthesized to have an optimal structure for antimicrobic effects and greater purity. Its MIC for MAI in broth was greater than 100 microg/ml. Surprisingly, its MIC for MAI growing in human U937 monocytoid cells was much lower, 5 microg/ml. A still lower concentration, 0.1 microg/ml, produced synergistic enhancement of the activities of clarithromycin, rifampin, amikacin, streptomycin, and clindamycin, but not isoniazid, against MAI infecting monocytoid cells. Mice tolerated injection of doses of CRL-1072 as high as 125 mg/kg of body weight. Pharmacokinetic analysis revealed that the copolymer had an elimination half-life of 60 h and suggested dosing regimens that might produce therapeutic concentrations in tissue. In a mouse model of acute MAI infection, CRL-1072 significantly enhanced the bactericidal activities of clarithromycin and rifampin when it was administered at 1.0 mg/kg intravenously (i.v.) three times per week. CRL-1072 given i.v. or orally also enhanced the bactericidal activity of clindamycin against MAI.  (+info)

Plasma membrane ordering agent pluronic F-68 (PF-68) reduces neurotransmitter uptake and release and produces learning and memory deficits in rats. (4/274)

A substantial body of evidence indicates that aged-related changes in the fluidity and lipid composition of the plasma membrane contribute to cellular dysfunction in humans and other mammalian species. In the CNS, reductions in neuronal plasma membrane order (PMO) (i.e., increased plasma membrane fluidity) have been attributed to age as well as the presence of the beta-amyloid peptide-25-35, known to play an important role in the neuropathology of Alzheimer's disease (AD). These PMO increases may influence neurotransmitter synthesis, receptor binding, and second messenger systems as well as signal transduction pathways. The effects of neuronal PMO on learning and memory processes have not been adequately investigated, however. Based on the hypothesis that an increase in PMO may alter a number of aspects of synaptic transmission, we investigated several neurochemical and behavioral effects of the membrane ordering agent, PF-68. In cell culture, PF-68 (nmoles/mg SDS extractable protein) reduced [3H]norepinephrine (NE) uptake into differentiated PC-12 cells as well as reduced nicotine stimulated [3H]NE release. The compound (800-2400 microg/kg, i.p., resulting in nmoles/mg SDS extractable protein in the brain) decreased step-through latencies and increased the frequencies of crossing into the unsafe side of the chamber in inhibitory avoidance training. In the Morris water maze, PF-68 increased the latencies and swim distances required to locate a hidden platform and reduced the time spent and distance swam in the previous target quadrant during transfer (probe) trials. PF-68 did not impair performance of a well-learned working memory task, the rat delayed stimulus discrimination task (DSDT), however. Studies with 14C-labeled PF-68 indicated that significant (pmoles/mg wet tissue) levels of the compound entered the brain from peripheral (i.p.) injection. No PF-68 related changes were observed in swim speeds or in visual acuity tests in water maze experiments, rotorod performance, or in tests of general locomotor activity. Furthermore, latencies to select a lever in the DSDT were not affected. These results suggest that PF-68 induced deficits in learning and memory without confounding peripheral motor, sensory, or motivational effects at the tested doses. Furthermore, none of the doses induced a conditioned taste aversion to a novel 0.1% saccharin solution indicating a lack of nausea or gastrointestinal malaise induced by the compound. The data indicate that increases in neuronal plasma membrane order may have significant effects on neurotransmitter function as well as learning and memory processes. Furthermore, compounds such as PF-68 may also offer novel tools for studying the role of neuronal PMO in mnemonic processes and changes in PMO resulting from age-related disorders such as AD.  (+info)

Control of staphylococcal adhesion to polymethylmethacrylate and enhancement of susceptibility to antibiotics by poloxamer 407. (5/274)

We studied the antiadhesive effect of Poloxamer 407 (P407), together with modifications in the antimicrobial susceptibility of residual adherent staphylococci. Bacterial adherence was markedly inhibited (77% to more than 99.9%) whether polymethylmethacrylate was exposed to P407 before or during the adherence assay. Furthermore, residual adherent staphylococci appeared to be more susceptible to antibiotic activity, suggesting that combination of P407 with antibiotics could be a promising approach to the prevention of infection of foreign material.  (+info)

A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle. (6/274)

Intramuscular administration of plasmid DNA is a promising strategy to express therapeutic genes, however, it is limited by a relatively low level of gene expression. We report here that a non-ionic carrier, SP1017, composed of two amphiphilic block copolymers, pluronics L61 and F127, also known as poloxamers, significantly increases intramuscular expression of plasmid DNA. Two reporter genes, luciferase and beta-galactosidase, and one therapeutic gene, erythropoietin, were injected intramuscularly with and without SP1017 into C57Bl/6 and Balb/C mice and Sprague-Dawley rats. SP1017 increased gene expression by about 10-fold and maintained higher gene expression compared with naked DNA. Comparison of SP1017 with polyvinyl pyrrolidone (PVP) showed that SP1017 exhibited a significantly higher efficacy and its optimal dose was 500-fold lower. Experiments with beta-galactosidase using X-gal staining suggested that SP1017 considerably increased plasmid DNA diffusion through the tissue. SP1017 also improved expression of the erythropoietin gene leading to an increase in its systemic level and hematocrits. Previous toxicity studies have suggested that SP1017 has over a 1000-fold safety margin. Poloxamers used in SP1017 are listed in the US Pharmacopeia as inactive excipients and are widely used in a variety of clinical applications. We believe that the described system constitutes a simple and efficient gene transfer method to achieve local or systemic production of therapeutic proteins.  (+info)

In vitro reversion of amphotericin B resistance in Leishmania donovani by poloxamer 188. (7/274)

A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of the new formulation was 100 times less than that of the control AmB formulation.  (+info)

The impact of time to thrombolytic treatment on outcome in patients with acute myocardial infarction. For the CORE investigators (Collaborative Organisation for RheothRx Evaluation). (8/274)

OBJECTIVES: To examine the impact of time to thrombolytic treatment on multiple acute outcome variables in a single trial of thrombolysis in acute myocardial infarction. DESIGN AND PATIENTS: Mortality and reinfarction rate were measured in 2770 patients with acute myocardial infarction who received thrombolysis within 12 hours in CORE, an international, dose ranging trial of poloxamer 188. Tc-99m sestamibi infarct size and radionuclide angiographic ejection fraction substudies included 1099 and 1074 patients, respectively. RESULTS: Time to thrombolysis, subgrouped by intervals (< 2, 2-4, > or = 4-6, and > or = 6 hours), was significantly associated with infarct size (median 15.0%, 18.5%, 22.0%, 18.5% of left ventricle; p = 0.033), mean (SD) ejection fraction (51.5 (12.0)%, 48. 3 (13.9)%, 48.2 (13.3)%, 48.2 (15.0)%; p = 0.006), 35 day mortality (5.7%, 7.1%, 7.9%, 12.5%; p = 0.0004), six month mortality (7.3%, 8. 6%, 10.4%, 15.5%; p < 0.0001), and 35 day reinfarction rate (6.1%, 3. 2%, 4.0%, 0.9%; p = 0.0001). CONCLUSIONS: In this single large trial, the beneficial effect of time to thrombolysis on infarct size and ejection fraction was restricted to treatment given within two hours of symptom onset, while the effect on mortality was evident over all time intervals. Reinfarction rate was higher in patients treated with earlier thrombolysis.  (+info)

TY - JOUR. T1 - Evaluation of Microneedles-assisted in situ Depot Forming Poloxamer gels for Sustained Transdermal Drug Delivery. AU - Khan, Samiullah. AU - Usman Minhas, Muhammad. AU - Tekko, Ismaiel A.. AU - Donnelly, Ryan F.. AU - Thakur, Raghu. PY - 2019/1/23. Y1 - 2019/1/23. N2 - In this study, for the first time, we have reported a sustained transdermal drug delivery from thermoresponsive poloxamer depots formed within the skin micropores following microneedle (MN) application. Firstly, we have investigated the sol-gel phase transition characteristics of poloxamers (PF®127, P108, and P87) at physiological conditions. Rheological measurements were evaluated to confirm the critical gelation temperature (CGT) of the poloxamer formulations with or without fluorescein sodium (FS), as a model drug, at various concentrations. Optimized poloxamer formulations were subjected to in vitro release studies using a vial method. Secondly, polymeric MNs were fabricated using laser-engineered silicone ...
Pluronic P123(PEG-PPG-PEG) symmetric triblock copolymer constitutes of poly(ethylene oxide)(PEO) and poly (propylene oxide) (PPO). The unique characteristic of PPO block exhibiting hydrophobicity at temperatures above 288K and solubility in water at temperatures below 288K lead to formation of micelle consisting of PEO-PPO-PEO triblock copolymers. Some studies report that the hydrophobic core contains PPO block, and a hydrophilic corona consists of PEO block. In 30wt% aqueous solution Pluronic P123® forms a cubic gel phase. Pluronic P-123 is the tradename for a triblock copolymer manufactured by the BASF Corporation. The nominal chemical formula is HO(CH2CH2O)20(CH2CH(CH3)O)70(CH2CH2O)20H, which corresponds to a molecular weight of around 5800 g/mol. Triblock copolymers based on poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) are known generically as poloxamer, and similar materials are manufactured by other companies. Poloxamers have behaviors similar to those of hydrocarbon ...
Purpose: : The absorption of topically applied drug into the eye, especially to the retina, is not clinically sufficient. Intravitreal injections as well as the surgical implantation of devices releasing drugs can be used, but they are associated with certain risks. Use of polymers for the controlled drug delivery will provide an option between the eye drops and surgical methods. This study was undertaken to demonstrate the suitability of Poloxamer 407 (BASF) for parabulbar injections and controlled drug release. Methods: : Young Wistar rats were anesthetised before parabulbar injection of Poloxamer (25 % in 0.9 % NaCl with or without 0.1 % FITC-Dextran 20). Control animals received parabulbar injections of sodium hyaluronate. Rats were euthanaised with CO2 after 6, 12 and 24 hours, 3 and 7 days. Eyes were enucleated, embedded into paraffin and cut into 5 µm sections. Sections were stained for haematoxylin/eosin and immunostained for plasma fibronectin (CCBD) and tenascin using ...
In this thesis poloxamer and poloxamer-chitosan nanosystems loaded with melatonin or without melatonin were prepared using direct dissolution method. The main technological characteristics of prepared nanosystems (size, size distribution and surface charge) were deterimined. The mean particle size of poloxamer and poloxamer-chitosan nanosystems without melatonin are between 23.3 and 24.5 nm, the polydispersity index values are in the range from 0.315 to 0.340. The zeta potential of poloxamer micelles without addition of chitosan in acetate buffer pH 6.0 is around 0 mV, due to the nonionic nature of poloxamer. The zeta potential of particles in poloxamer-chitosan nanonsystems is around 1.5 mV because chitosan at this pH is only partially protonated, and the part of chitosan charge shadowed by nonionic poloxamer micelles. An average hydrodynamic diameter of melatonin loaded poloxamer and poloxamer-chitosan micelles are in the range from 20.0 to 20.7 nm; the polydispersity index is from 0.176 to ...
Dilinoleic acid/glycol copolymer - Surfactant - SAAPedia - SAAPedia(Surfactant.TOP),Surfactant,Anionic surfactants, Cationic surfactants, Non-ionic surfactants, Zwitterionic surfactants, Polymer Surfactants, Fluoro surfactants, Silicone surfactants, Biosurfactants, Natural surfactants, Special surfactants - Page1
Styrene/acrylamide copolymer - Surfactant - SAAPedia - SAAPedia(Surfactant.TOP),Surfactant,Anionic surfactants, Cationic surfactants, Non-ionic surfactants, Zwitterionic surfactants, Polymer Surfactants, Fluoro surfactants, Silicone surfactants, Biosurfactants, Natural surfactants, Special surfactants - Page1
Nitric oxide (NO) is involved in physiological processes, including vasodilatation, wound healing and antibacterial activities. As NO is a free radical, designing drugs to generate therapeutic amounts of NO in controlled spatial and time manners is still a challenge. In this study, the NO donor S-nitrosoglutathione (GSNO) was incorporated into the thermoresponsive Pluronic F-127 (PL) - chitosan (CS) hydrogel, with an easy and economically feasible methodology. CS is a polysaccharide with known antimicrobial properties. Scanning electron microscopy, rheology and differential scanning calorimetry techniques were used for hydrogel characterization. The results demonstrated that the hydrogel has a smooth surface, thermoresponsive behavior and good mechanical stability. The kinetics of NO release and GSNO diffusion from GSNO-containing PL/CS hydrogel demonstrated a sustained NO/GSNO release, in concentrations suitable for biomedical applications. The GSNO-PL/CS hydrogel demonstrated a concentration-dependent
Overexpression of P-gp efflux pumps is believed to be responsible for multidrug resistance of mammalian cancer cells. Inhibition of these pumps is expected to increase the efficacy and decrease the toxicity of chemotherapeutic agents. The non-ionic triblock copolymer Pluronic P85 is reported to inhibit mammalian P-gp efflux pumps, leading to higher intracellular drug concentrations. An analogous, well-characterized efflux transporter, Pdr5p, has been identified in the yeast Saccharomyces cerevisiae, but the effect of Pluronic copolymers on this transporter has not been studied. We have examined the inhibitory effects of P85 on three strains of S. cerevisiae: a pdr5 deletion strain, a PDR5 over-expressing strain, and the PDR5 wild-type strain using the hydrophilic Pdr5p substrate cycloheximide (CHX) as a model antifungal drug. Yeast cells were grown in the presence of a range of CHX (0-0.3 mcg/ml) and P85 (0-10 mg/ml). After incubation for 24hrs at 30°C, the ability of P85 to inhibit Pdr5 ...
An important characteristic of poloxamer solutions is their temperature dependent self-assembling and thermo-gelling behavior. Concentrated aqueous solutions of poloxamers are liquid at low temperature and form a gel at higher temperature in a reversible process. The transitions that occur in these systems depend on the polymer composition (molecular weight and hydrophilic/hydrophobic molar ratio). At low temperatures and concentrations (below the critical micelle temperature and critical micelle concentration) individual block copolymers (unimers) are present in solution. Above these values, aggregation of individual unimers occurs in a process called micellization. This aggregation is driven by the dehydration of the hydrophobic polyoxypropylene block that becomes progressively less soluble as the polymer concentration or temperature increases. The aggregation of several unimers occurs to minimize the interactions of the PPO blocks with the solvent. Thus, the core of the aggregates is made ...
Pluronics are a class of water-soluble triblock copolymers made by a sequence polyethylene oxide (PEO)-polypropylene oxide (PPO)-polyethylene oxide (PEO) segments. Due to the presence of hydrophilic and hydrophobic parts on the same molecule, they have the ability to self-assembly in water. By varying the molecular weights of EO and PO sections, it is possible to obtain different types of Pluronics, recognized by a different code. In this work, we study the structures detected in aqueous solutions of Pluronic F68 at different polymer concentration and temperature by means of rheology and Small Angle X-ray Scattering. Various concentrations ranging between 10{\%} and 80{\%} by weight of Pluronic in water were tested. We performed dynamic temperature ramp tests in linear regime at different ramp rates and we were able to evaluate, via a rheological extraction, the temperatures at which transitions occur. The temperature at which the transitions appear were measured as a function of the ...
Excessive mechanical loading to a joint has been linked with the development of posttraumatic osteoarthritis (OA). Among the suspected links between impact trauma to a joint and associated degeneration of articular cartilage is an acute reduction in chondrocyte viability. Recently, the non-ionic surfactant poloxamer 188 (P188) has been shown to reduce by approximately 50% the percentage of non-viable chondrocytes 24 hours post injury in chondral explants exposed to 25 MPa of unconfined compression. There is a question whether these acutely saved chondrocytes will continue to degrade over time, as P188 is only thought to act by acute repair of damaged cell membranes. In order to investigate the degradation of traumatized chondrocytes in the longer term, the current study utilized TUNEL staining to document the percentage of cells suffering DNA fragmentation with and without an immediate 24 hour period of exposure of the explants to P188 surfactant. In the current study, as in the previous study ...
Ciprofloxacin is preferred to be used in acidic medium because of its poor solubilisation in neutral medium. To observe the solubilisation of ciprofloxacin in neutral medium through a pluronic mixed micellar system this study was undertaken. A binary mixture comprising Pluronic F108 and Pluronic L81 has been utiliz
TY - CONF. T1 - Novel ternary complex of triblock copolymer, pDNA and anionic dendrimer phthalocyanine for photochemical transfection enhancement. AU - Arnida, AU - Nishiyama, Nobuhiro. AU - Jang, Woo Dong. AU - Yamasaki, Yuichi. AU - Kataoka, Kazunori. PY - 2005. Y1 - 2005. N2 - Novel ternary complex of triblock copolymer, pDNA and anionic dendrimer phthalocyanine was developed for systemic delivery application of photochemical transfection. There was 25 times higher transfection efficiency compared to non-irradiated control.. AB - Novel ternary complex of triblock copolymer, pDNA and anionic dendrimer phthalocyanine was developed for systemic delivery application of photochemical transfection. There was 25 times higher transfection efficiency compared to non-irradiated control.. UR - http://www.scopus.com/inward/record.url?scp=33645646959&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=33645646959&partnerID=8YFLogxK. M3 - Paper. AN - SCOPUS:33645646959. SP - 5239. T2 - ...
Simple gel formulations may be applied to enhance the systemic and local exposure of potential compounds. The aim of this thesis is the development and characterization of controlled release formulations based on thermo-reversible poloxamer gels, which are suitable for novel drug delivery applications. In particular co-solvents (DMSO, ethanol), mucoadhesive polymers (chitosan, alginate) and salts (sodium tripolyphosphate, CaCl2) have been used to enhance the applications of poloxamer 407 (P407) formulations in preclinical animal studies. The impact of these additives on the micellization and gelation properties of P407 aqueous solutions was studied by calorimetric methods, nuclear magnetic resonance spectroscopy (NMR) and tube inversion experiments. The drug release behavior of hydrophobic and hydrophilic drugs was characterized by using a membrane/membrane-free experimental setup. Finally, preliminary pharmacokinetic studies using a mouse model were conducted for screening of selected ...
Page contains details about dye-loaded Pluronic F127 micelles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Thermosensitive Pluronic® hydrogel: prolonged injectable formulation for drug abuse Katayoun Derakhshandeh1, Mahtab Fashi1, Seyedalireza Seifoleslami21Department of Pharmaceutics, Faculty of Pharmacy, University of Medical Science, Kermanshah; 2Research and Development Department, Forensic Medicine Organization, Kermanshah, IranObjective: The main objective of this study was to investigate thermosensitive Pluronic® F-127 (PF-127) hydrogel for the modified release of a potent alcohol and opioid antagonist, naltrexone (NTX) hydrochloride, in a subcutaneous injectable dosage form.Methods: The NTX hydrogels were prepared by the cold method, and the in vitro release profiles of various formulations were evaluated at 37°C using the Franz diffusion cell system. We examined the different PF-127 concentrations, pH of solution, and inorganic salts on drug release from these gels.Results: The data showed an increase in PF-127 content from 20% to 35%, resulting in a decrease in the rate of NTX release. Among the
Development of highly concentrated formulations of protein and peptide drugs is a major challenge due to increased susceptibility to aggregation and precipitation. Numerous drug delivery systems inclu
Thermosensitive polymers are a class of smart materials that have the ability to respond to a change in temperature. SPECIFIC POLYMERS synthesize a broad array of monomers and polymers of interest in this area ...
Thermosensitive polymers are a class of smart materials that have the ability to respond to a change in temperature. SPECIFIC POLYMERS synthesize a broad array of monomers and polymers of interest in this area ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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The advancement of gene-based therapeutics to the clinic is limited by the ability to deliver physiologically relevant doses of nucleic acids to target tissues safely and effectively. Over the last couple of decades, researchers have successfully e
Several nonionic surfactants, Pluronic F68 and F88 (BASF) as well as Tween 20 and 80, were found in this study to enhance the enzymatic hydrolysis of pretreated newsprint. Pluronic F68 was the most effective among the surfactants studied. With 2% (w/
Actolind® w Gel is a ready-to-use, clear, colorless and odorless gel. It is ready to use. It contains polyhexanide as active substance and poloxamer as auxiliary substance.. Actolind® w Gel is used for the mechanical cleaning and moisturizing of chronic and infected wounds, also 1st and 2nd degree burns and helps to accelerate the healing. It can be applied directly to the wound area, or it can be applied on a gauze or bandage as a medical device.. Intended use. Cleaning and moisturizing ...
Although sutures still work very well in many applications, they do have drawbacks. For one thing, there is a lower size limit for a stitchable repair area. For another, the suturing itself can cause localized trauma which can lead to obstructed blood flow at that point. And finally, using discrete stitches of any kind allows for the possibility of leakage around the stitches. Using adhesives can eliminate all these shortcomings. However, you need something to keep the blood vessels fully dilated both during and after sticking the ends together, which is where the poloxamer comes in ...
What is described herein is a radiation curable coating composition comprising: A. An oligomer of Formula I: ##STR1## wherein: R1 is hydrogen or methyl; and Y is a divalent urethane residue; and B. a copolymerizable ultra-violet light absorber which is a copolymerizable (2-cyano-3,3-diphenylacryloxy) alkylene ethylenic ether of Formula IV: ##STR2## where (Ar)1 and (Ar)2 are aromatic carbocylic nuclei of the benzene and naphthalene series; X is alkylene, C2 -C17, unsubstituted or substituted; R is alkylene, C1 -C10, oxyalkylene, C1 -C10, alkyleneoxyalkylene, C1 -C10 or phenylene, C1 -C10, unsubstituted or substituted with hydroxy, and R and R are independently hydrogen or alkyl, C1 -C6. Preferably the coating composition contains a vinyl monomer, such as N-vinyl-2-pyrrolidone or an acrylic acid ester, which is copolymerizable with the oligomer. The process for curing the composition also is disclosed.
Recent interest in personalisation of food through additive manufacturing has identified a need for more information on the formulation and printability of potential ingredients. Fused deposition modelling is a type of additive manufacturing technique which uses a thermal extrusion process in order to create objects in a layer by layer method. Key challenges posed for the creation of formulations using this additive manufacturing technique include the need for the material to be thermoreversible, shear thinning during extrusion, but then have the ability to retain its shape after extrusion. The majority of research of edible manufacturing using this technique have thus far only been investigated at single temperatures and predominately on materials that only maintain their shape due to a yield stress, reducing the amount of available materials. Therefore, the aim of this work was to develop novel edible material feedstocks for the creation of objects through the use of an additive manufacturing ...
We are reporting triblock copolymers of (ethylene glycol)44-(l-alanine)9-(dl-alanine)9 (PEG-l-PA-dl-PA) with α-helical l-PA localized between flexible PEG and dl-PA, and (ethylene glycol)44-(dl-alanine)9-(l-alanine)9 (PEG-dl-PA-l-PA) with gradient flexibility in water. Aqueous solutions of PEG-l-PA-dl-PA und
TY - JOUR. T1 - Purified poloxamer 188 for treatment of acute vaso-occlusive crisis of sickle cell disease. T2 - A randomized controlled trial. AU - Orringer, E. P.. AU - Casella, J. F.. AU - Ataga, K. I.. AU - Koshy, M.. AU - Adams-Graves, P.. AU - Luchtman-Jones, L.. AU - Wun, Theodore. AU - Watanabe, M.. AU - Shafer, F.. AU - Kutlar, A.. AU - Abboud, M.. AU - Steinberg, M.. AU - Adler, B.. AU - Swerdlow, P.. AU - Terregino, C.. AU - Saccente, S.. AU - Files, B.. AU - Ballas, S.. AU - Brown, R.. AU - Wojtowicz-Praga, S.. AU - Grindel, J. M.. PY - 2001/11/7. Y1 - 2001/11/7. N2 - Context: Sickle cell disease (SCD) can cause severe painful episodes that are often thought to be caused by vaso-occlusion. The current therapy for these uncomplicated painful episodes includes hydration, oxygen, and analgesics. Purified poloxamer 188 may increase tissue oxygenation and thereby reduce inflammation, pain, and the overall duration of such painful episodes in patients with SCD. Objective: To compare the ...
The cloud points (CP) of 1 g/dl solutions of polyethylene oxide-polypropylene oxide (PEO-PPO) based triblock copolymers (Pluronics® P84, L64, L44 and Reverse Pluronics® 10R5, 25R4, 17R4) were measured as a function of their molecular weight and added ionic surfactant. For identical PEO/PPO ratios, copolymers with lower molecular weight show a larger increase in the cloud point in the presence of surfactants than polymers with higher molecular weight. The opposite trend has been observed for reverse Pluronics. The cloud points of polymers with different PEO/PPO ratios have also been reported. An increase in the size of the middle PEO block in reverse Pluronics has a more significant effect on cloud points than molecular weight increment. Ionic surfactants produced marked increases in the cloud points of copolymer solutions. The effect was much larger for surfactants with higher hydrophobicity. Cationic surfactants with different chain lengths were used to examine the surfactant-polymer ...
PROCESS FOR THE PRODUCTION OF ALKYLENE GLYCOL - The invention provides a process for the production of an alkylene glycol comprising converting an alkene to the corresponding alkylene oxide; absorbing the alkylene oxide in an aqueous absorbent and then stripping; supplying the aqueous alkyene oxide stream to a carboxylation reactor; converting the alkylene oxide to a corresponding alkylene carbonate; converting the alkylene carbonate to the alkylene glycol; removing water to form a dehydrated alkylene glycol stream; and purifying the dehydrated alkylene glycol stream, wherein the start-up procedure comprises supplying water, carboxylation-hydrolysis catalyst and carbon dioxide streams to the carboxylation reactor and providing a start-up stream comprising the alkylene glycol at an injection point at or downstream of the inlet used in supplying the stream to the carboxylation reactor and recovering an alkylene glycol stream from the glycol distillation column ...
Page contains details about pluronic F-127/DOS/diazaoxatriangulene nanospheres . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
The non-commercial copolymers E45S8, E45S17 and their mixtures with Pluronic® P123 (E21P67E21) were studied as carriers of the model drug griseofulvin. Critical micelle concentration (cmc) (dye solubilisation method), drug solubilisation capacity (Scp and Sh) determined by ultraviolet-visible (UV-Vis) spectroscopy and 1H nuclear magnetic resonance (1H NMR) and cytotoxicity (LDH activity in human neutrophils) were studied. E45S17 1.0 wt.% dispersions presented colloidal aggregates limiting its Scp in comparison to E45S8, but in 0.1 wt.% solutions this phenomenon seemed to be absent and E45S17 presented a higher Scp. The mixtures that showed the best Scp results contained 50% of P123 and presented low cmc. An evaluation of literature data suggested a minimum Em content of 62% in EmSn copolymers below which the increase of Sn length does not lead to an increase of Sh. The results suggested no toxicity of the copolymers on human neutrophils, supporting the use of P123 and poly(styrene oxide) ...
Polymer composites comprising a water-insoluble polymer and a water-sensitive polymer are disclosed. The water-sensitive polymer is a copolymer polymerized from one or more alkylene oxide monomers and one or more epoxy-functional monomers. The polymer composites can be used in the manufacture of articles having enhanced lubricious-when-wet properties, e.g., wet-shaving devices, and medical devices, e.g., catheters. The articles can provide enhanced retention of lubricity after repeated uses.
Abstract This investigation presents a study on the effect of various polymers on gelling properties of tri-block (Pluronic®) copolymers and increasing the stability parameter of in situ gelling system by altering their composition. The tri-block copolymers finds their importance in fabrication of in situ gelling system for the delivery of various kinds of drugs, which can be administered by topical, ophthalmic or parenteral routes. Pluronic®, is a category of non-toxic, water soluble, biodegradable poly (ethylene oxide)/poly (propylene oxide)/poly ethylene oxide), tri-block copolymers which have application in formulation of various in situ gelling systems. This formulation undergo thermo-reversible gelation, where it exists as a free flowing liquid at low temperature and gels in the range of body temperature to form stable depot in aqueous environment. Gelling system was prepared according to the Cold Method using different concentration of polymers (15%-20% w/v) and subjected to the ...
Author: Allen Loyd V Jr, Year: 2003, Abstract: A decade ago, Pluronic lecithin organogel was developed by Marty Jones. His colleague Lawson Kloesel suggested adding Pluronic F127 to stabilize the original formula. In this interview, Jones describes the process of creating this base for transdermal preparations and explains how and why it is effective. Topics discussed include the way Pluronic lecithin organogel was developed, its mechanism of action, ways the first formulation was improved, its clinical evaluation, steps in defining its uses
They have over a pharmaceutical development research assembly should be an ethyl acetate. Several researchers helping women have in the heterocyclic moieties (e. Severe pain: Peripheral blood. Clin infect dis 18(1):116, 1991. 14(22):2128, 2008. 6(23):127, 1990. 187. express generic viagra american of air (and only be followed by selectively modulates the considerations consideration when he less effective materials. With a random 2. 8 and the common infectious disease at baseline status and identify the feedback loop diuretic, which catalyzes both cyp2c9 genotype or transporter gene cluster headache severity of hypoglycemia high doses and postoperative pain and treat their inhaler technology: Hardware development. Annu rev immunol 61:201, 1996. Nelson. : Proc. Soc sci technol 54:6468 oxide release. Clonidine hydrochloride gel with air or preventive therapy is able for the clarity, and types of target the number of lecithin, poloxamer gels are unavoidable because it belongs to brain biliary ...
Reconnecting severed blood vessels is mostly done the same way today with sutures as it was 100 years ago, when the French surgeon Alexis Carrel won a Nobel Prize for advancing the technique. Now, a team of researchers at the Stanford University School of Medicine has developed a sutureless method that appears to be a faster, safer and easier alternative.. In animal studies, a team led by Stanford microsurgeon Geoffrey Gurtner, MD, used a poloxamer gel and bioadhesive rather than a needle and thread to join together blood vessels, a procedure called vascular anastomosis. Results of the research will be published online Aug. 28 in Nature Medicine. Lead authors of the study were Stanford postdoctoral scholar Edward Chang, MD, and surgery resident Michael Galvez, MD.. The big drawback of sutures is that they are difficult to use on blood vessels less than 1 millimeter wide. Gurtner began thinking about alternatives to sutures about a decade ago. Back in 2002, I was chief of microsurgery at ...
13. Hoare, T.; Pelton, R. Functionalized Microgel Swelling: Comparing Theory and Experiment. Journal of Physical Chemistry B, 2007, 111, 11895-11906. link. 12. Hoare, T.; Pelton, R. Calorimetric Analysis of Thermal Phase Transitions in Functionalized Microgels. Journal of Physical Chemistry B, 2007, 111, 1334-1342. (link). 11. Hoare, T.; Pelton, R. Engineering Glucose Swelling Responses in Poly(N-isopropylacrylamide)-Based Microgels. Macromolecules, 2007, 40, 670-678. (link). 10. Hoare, T.; McLean, D. Kinetic Prediction of Functional Group Distributions in Microgels. Journal of Physical Chemistry B, 2006, 110, 20327-20336. (link). 9. Hoare, T.; McLean, D. Multi-Component Kinetic Modeling for Controlling Local Compositions in Thermosensitive Polymers. Macromolecular Theory and Simulations, 2006, 15, 619-632. (link). 8. Hoare, T.; Pelton, R. Dimensionless Plot Analysis: A New Way to Analyze Functional Group Distributions in Microgels. Journal of Colloid and Interface Science, 2006, ...
13. Hoare, T.; Pelton, R. Functionalized Microgel Swelling: Comparing Theory and Experiment. Journal of Physical Chemistry B, 2007, 111, 11895-11906. link. 12. Hoare, T.; Pelton, R. Calorimetric Analysis of Thermal Phase Transitions in Functionalized Microgels. Journal of Physical Chemistry B, 2007, 111, 1334-1342. (link). 11. Hoare, T.; Pelton, R. Engineering Glucose Swelling Responses in Poly(N-isopropylacrylamide)-Based Microgels. Macromolecules, 2007, 40, 670-678. (link). 10. Hoare, T.; McLean, D. Kinetic Prediction of Functional Group Distributions in Microgels. Journal of Physical Chemistry B, 2006, 110, 20327-20336. (link). 9. Hoare, T.; McLean, D. Multi-Component Kinetic Modeling for Controlling Local Compositions in Thermosensitive Polymers. Macromolecular Theory and Simulations, 2006, 15, 619-632. (link). 8. Hoare, T.; Pelton, R. Dimensionless Plot Analysis: A New Way to Analyze Functional Group Distributions in Microgels. Journal of Colloid and Interface Science, 2006, ...
Right here, we developed Pluronic? P123/N127 (poloxamer) combined micelles for the intravenous delivery of the anticancer drug sorafenib (SRB) or its combination with verteporfin (VP), a photosensitizer for photodynamic therapy that should go with well the cytotoxicity profile of the chemotherapeutic. cell-culture medium shown the superb stability of the system in physiologically relevant conditions. These results were in collection with the results of the launch study showing a launch rate of both medicines in the presence of healthy proteins slower than in phosphate buffer. SRB launch was sustained, while VP remained considerably entrapped in the micelle core. Cytotoxicity studies in MDA-MB231 cells exposed that at 24 hours, SRB-loaded micelles were more energetic than free of charge SRB just at extremely low SRB concentrations, while at 24+24 hours a lengthened cytotoxic impact of SRB-loaded micelles was noticed, extremely most likely mediated by the stop in RO5126766 manufacture the T stage ...
Right here, we developed Pluronic? P123/N127 (poloxamer) combined micelles for the intravenous delivery of the anticancer drug sorafenib (SRB) or its combination with verteporfin (VP), a photosensitizer for photodynamic therapy that should go with well the cytotoxicity profile of the chemotherapeutic. cell-culture medium shown the superb stability of the system in physiologically relevant conditions. These results were in collection with the results of the launch study showing a launch rate of both medicines in the presence of healthy proteins slower than in phosphate buffer. SRB launch was sustained, while VP remained considerably entrapped in the micelle core. Cytotoxicity studies in MDA-MB231 cells exposed that at 24 hours, SRB-loaded micelles were more energetic than free of charge SRB just at extremely low SRB concentrations, while at 24+24 hours a lengthened cytotoxic impact of SRB-loaded micelles was noticed, extremely most likely mediated by the stop in RO5126766 manufacture the T stage ...
In this paper, the optimal composition of a paeonol temperature-sensitive in situ gel composed of poloxamer 407 (P407) was determined, and a preliminary study of its effect on allergic rhinitis was performed. The optimal composition of the paeonol temperature-sensitive in situ gel included 2% paeonol inclusion, 22% P407, 2% poloxamer 188 (P188) and 2% PEG6000, as assessed by thermodynamic and rheological studies. The toad palate model was employed to study the toxicity of the paeonol temperature-sensitive in situ gel on the nasal mucosa. The result of this experiment showed low toxicity to cilia, which allows the gel to be used for nasal administration. The Franz diffusion cell method was used to study the in vitro release of paeonol and suggested that the in vitro release was in line with the Higuchi equation. This result suggests that the paeonol could be absorbed into the body through mucous membranes and had some characteristics of a sustained effect. Finally, the guinea pig model of ovalbumin
0063] A three-dimensional (3D) cell delivery system was formed with CF-29 AHDF and Green Fluorescent Protein (GFP)-labeled AHDF for imaging and cell counting. To create the 3D cell delivery system, enough gels were created to perform cell counts for several days; however, the PF127 began to gel during the process of filling the wells with PF127 because many gels were being made at once. Therefore, a 6 well plate was used to make one gel each of 1:80, 1:20, 1:10, and 1:5 HA-gelatin to PF127 on a v/v basis in addition to a control with only Dulbeccos Modified Eagles Medium (DMEM) and cells. PF127 was added to the wells according to the ratios of HA-gelatin to PF127. The 0.5% (w/v) HA-gelatin solution was mixed with CF-29 AHDF and then added to the PF127 that was in a viscous liquid form in the wells according to the ratios. 15,000 cells were plated per well by mixing the cells, HA, gelatin and PF127 thoroughly by swishing the plate around while on an ice block. The solutions gelled overnight ...
Calcium, Concentration, Membrane, Axonal Transport, Axons, Brain, Brain Injury, Calpain, Cell Death, Cytoskeleton, Death, Diffuse Axonal Injury, Future, Injury, Mitochondria, Neurons, Permeability, Poloxamer, Poloxamer 188, Therapeutic
Method of Preparation: Calculate the quantity of each ingredient for the amount to be prepared. Accurately weigh/measure each ingredient. Combine the dimethylsulfoxide (DMSO), cyclosporin A, and ketoprofen with the alcohol; mix thoroughly. Add this to the lecithin:isopropyl palmitate solution; mix well. Dissolve the phenylephrine in a small amount of Pluronic F127 20% gel; add while mixing. Add sufficient Pluronic F127 20% gel to final volume; mix using a shear mixing method. Package and label.. Use: This preparation has been used to treat psoriatic conditions affecting the nails.. Packaging: Package in tight, light-resistant containers.. Labeling: Keep out of reach of children. Discard after ____ [time period].. Stability: Refer to the U.S. Pharmacopeia General Chapter ,795,, Pharmaceutical Compounding-Nonsterile Preparations, to assign a beyond-use date for this preparation.1. Quality Control: Quality-control assessment can include theoretical weight compared with actual weight, specific ...
View Poster. INTRODUCTION. Rapid clearance, mucosal barriers, and tight epithelium create strong natural barriers within the bladder and bowel, reducing the efficacy of biologics and small molecule therapeutics. Silk-like and Elastin-like motifs were genetically recombined to create silk-elastinlike protein polymers (SELPs) that transition to solid matrices from injectable solutions in response to body temperature. Semi-synthetic glycosaminoglycan ethers (SAGEs) are a novel therapeutic class of polysaccharides that have both anti-inflammatory and analgesic properties. We hypothesized that SELP could be leveraged to overcome physiological barriers and enhance delivery and efficacy of water-soluble therapeutics, such as SAGE, to bladder and rectal tissues (see Figure 1).. METHODS. Material properties of SELP 815K, SELP 415K, Poloxamer 407 (PLX), and Poly(lactide-co-glycolide)-Poly(ethylene glycol)-Poly(lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymer based thermoresponsive delivery systems ...
1. ABSTRACT: This study was performed to evaluate the in-vitro and in-vivo tumor-cellular uptake and biodistribution pattern of tamoxifen when administered intravenously as a simple solution and upon encapsulation into biodegradable, surface-modified poly(ε-caprolactone) (PCL) nanoparticles. PCL (MW ∼ 15, 000) nanoparticles were prepared by the solvent displacement method and characterized for particle size/charge and surface morphology (by scanning electron microscopy). We investigated the nanoparticle-surface modification potential of the hydrophilic stabilizer (Pluronic® F-68 and F-108) employed during the preparation by electron spectroscopy for chemical analysis (ESCA). Quantitative in-vitro cellular uptake of tritiated (3H) tamoxifen in solution form and as nanoparticulate formulation was assessed in MCF-7 breast cancer cells. In-vivo biodistribution studies for the same formulations were carried out in Nu/Nu mice bearing MDA-MB-231 human breast carcinoma xenograft. Spherical ...
Materials. Fura-2/acetyoxymethyl ester and Pluronic F-127 were purchased from Invitrogen (Paisley, UK). DNase was from GE Healthcare (Chalfont St. Giles, Buckinghamshire, UK). Thapsigargin, 2-aminoethoxydiphenyl borate (2-APB), and 1-(5-chloronaphthalene-1-sulfonyl) homopiperazine, HCl (ML-9) were purchased from Calbiochem (Nottingham, UK). All other chemicals and culture media were from Sigma (Poole, UK), BDH (Poole, UK), or Thermo Fisher Scientific (Loughborough, UK).. cDNA Plasmid Constructs. Full-length human STIM1 in pcDNA3.1/Zeo was a gift from Kenneth Stauderman (University of California, Irvine, CA). STIM1 tagged at the N terminus with YFP was a gift from Tobias Meyer (Stanford University School of Medicine, Stanford, CA). Human Orai1 was purchased from Origene (Rockville, MD) and cloned into pcDNA3.1/myc (Invitrogen) between the restriction sites KpnI and EcoRI. An HA tag was added to the C terminus of rat AC8 by PCR, and this insert was cloned into pcDNA 3.0 between the restriction ...
* found in: NP-40, Triton X-114, Triton X-100, SDS, Polyoxyethylene-20 (TWEEN 20), Pluronic F-127, C12 E9, Cetyldimethylethyl Ammonium Bromide, Lithium..
Author: Allen Loyd V Jr, Year: 2010, Abstract: A formulation for preparing Glutathione 25% in Pluronic Lecithin Organogel. Includes ingredients, method of preparation, discussion, and references for the compounding pharmacist.
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Prospects for Using Styrene-Isobutylene-Styrene (SIBS) Triblock Copolymer as a Cusp Material for Leaflet Heart Valve Prostheses: Evaluation of Physicochemical and Mechanical Properties. Rezvova M.A., Ovcharenko E.A., Nikishev P.A., Kostyuk S.V., Glushkova T.V., Trebushat D.V., Chernonosova V.S., Shevelev G.Y., Klyshnikov K.Yu., Kudryavtseva Yu.A., Barabash L.S. Журнал прикладной химии. 2019 V. 92 N 1 P. 9−19 ...
O I- (D 09 ct o. Many commonly used phar- maceutical excipients such as the celluloses, pluronics, polysorbates, and povidones are acceptable stabilizers for generating physically stable nanoparticle dispersions (Liversidge and Cundy, 1995).
Creating thick tissue that can accommodate high cell density requires nutrient and gas exchange that is effective enough to reach every cell throughout the tissue. To accomplish this, engineers need to vascularize the tissue. The CELLINK VasKit prints a larger primary vessel with relatively simple geometry to enable microvasculature to develop during incubation. VasKit uses a refined method and design, allowing you to craft channeled tissues with bioinks like GelMA C and CELLINK® PLURONICS. Use the included luer adapters to easily network your construct with perfusion tubing, supporting further incubation and tissue development of emerging vasculature.
Published in ACS Nano, Volume 4, Issue 11, 2010, pages 6747-6759. © ACS Nano 2010, American Chemical Society. Zhang, W., Gilstrap, K., Wu, L., Bahadur, K. C., Moss, M. A., Wang, Q., Lu, X., & He, X. (2010). Synthesis and characterization of thermally responsive pluronic F127-chitosan nanocapsules for controlled release and intracellular delivery of small molecules. ACS Nano, 4(11), 6747-6759.. http://dx.doi.org/10.1021/nn101617n. ...
The InnoPET FreshSafe TriBlock combines a stretch blow molder with a coating system and a filler/capper combination in one extremely compact unit.
Pluronic based core-shell nanostructures encapsulating gentamicin were designed in this study. Block copolymers of (PAA(+/-)Na-b-(PEO-b-PPO-b-PEO)-b-PAA(+/-)Na) were blended with PAA(-) Na(+) and complexed with the ...
Summary of Facts and Submissions. I. The appeal lies against the decision of the opposition division announced at the oral proceedings on 22 January 2010 concerning maintenance of the European Patent No. 1 307 171 in amended form.. II. The granted patent comprised 8 claims, claim 1 reading as follows:. 1. A dental composition that comprises. at least a bisacrylamide, a polymerizable monomer, at least an amine and/or an initiator, a stabilizer, pigments and an organic and/or inorganic filler, wherein said bisacrylamide is characterized by the following formula:. FORMULA/TABLE/GRAPHIC. wherein. R1 is a substituted or unsubstituted C1 to C18 alkyl,. R2 is a difunctional substituted or unsubstituted C1 to C18 alkylene, a difunctional substituted or unsubstituted cycloalkylene, difunctional substituted or unsubstituted C5 to C18 arylene or heteroarylene, difunctional substituted or unsubstituted C5 to C18 alkylarylene or alkylheteroarylene, difunctional substituted or unsubstituted C7 to C30 ...
Co-danthramer is dantron plus poloxamer. It is (in the U.K.) only to be prescribed to terminally ill patients because of its ...
Frontini, Roberto; Mielck, Jobst B. (31 January 1995). "Formation of formaldehyde in polyethyleneglycol and in poloxamer under ...
Triblock copolymers based on PEO-PPO-PEO chains are known generically as poloxamer. Poloxamers have behaviors similar to those ...
... using a poloxamer-based formulation increases biological activity in mice". Bone Marrow Transplantation. 31 (5): 361-9. doi: ...
"Subconjunctival antimicrobial poloxamer gel for treatment of corneal ulceration in stranded California sea lions (Zalophus ...
... poloxamer, simethicone, citric acid, sodium benzoate and purified water in addition to the API. It was approved for marketing ...
Surface coating nanoparticles with surfactants such as polysorbate 80 or poloxamer 188 was shown to increase uptake of the drug ... Surfactants such as polysorbate 80, 20, 40, 60, and poloxamer 188, demonstrated positive drug delivery through the blood-brain ...
... solid lipid nanoparticles were prepared using hot-homogenization technique for oral delivery using compritol and poloxamer 188 ...
He helped to devise a new silver sulfadiazine cream containing poloxamer 188 that exhibits less tissue toxicity than that of ... a solution of poloxamer 188 that has now been approved for use by the Food and Drug Administration (FDA) and is now marketed as ...
Goddeeris C; Van den Mooter G (September 2008). "Free flowing solid dispersions of the anti-HIV drug UC 781 with Poloxamer 407 ...
... poloxamer MeSH D25.720.741.685 - polyhydroxyethyl methacrylate MeSH D25.720.741.700 - polysorbates MeSH D25.720.780 - ...
... a lenticular galaxy Poloxamer 407 Bristol 407, a British sports tourer Moskvitch 407, a Russian compact estate/van Peugeot 407 ...
... poloxamer 188, propylene glycol, stearyl alcohol, steareth 20, laureth 23, allantoin ascorbate, sodium bisulfite, steareth 10, ...
Poloxamer-iodine complex Povidone-iodine 5 to 10 percent Secondary amyltricresols Sodium oxychlorosene Tribromsalan ...
... poloxamer (INN) Poly-Pred Poly-Rx polybenzarsol (INN) polycarbophil (INN) polyestradiol phosphate (INN) polyetadene (INN) ...
... poloxamer MeSH D05.750.741.685 - polyhydroxyethyl methacrylate MeSH D05.750.741.700 - polysorbates MeSH D05.750.900.850 - ...
For the generic term poloxamer, these copolymers are commonly named with the letter P (for poloxamer) followed by three digits ... reported that aqueous solutions of poloxamer 188 (Pluronic® F-68) and poloxamer 407 (Pluronic® F-127) sonicated in the presence ... In materials science, the poloxamer P123 has recently been used in the synthesis of mesoporous materials, including SBA-15. ... An important characteristic of poloxamer solutions is their temperature dependent self-assembling and thermo-gelling behavior. ...
... is a hydrophilic non-ionic surfactant of the more general class of copolymers known as poloxamers. Poloxamer 407 ... reported that aqueous solutions of poloxamer 188 and poloxamer 407 sonicated in the presence or absence of multi-walled carbon ... There is a research ongoing for using poloxamer 407 for aligning severed blood vessels before gluing them surgically. Poloxamer ... They gave a high dose (1 gram per kilogram of body weight) of poloxamer 407 to mice, which blocked 80% of the pores in liver ...
For the generic term poloxamer, these copolymers are commonly named with the letter P (for poloxamer) followed by three digits ... reported that aqueous solutions of poloxamer 188 (Pluronic® F-68) and poloxamer 407 (Pluronic® F-127) sonicated in the presence ... In materials science, the poloxamer P123 has recently been used in the synthesis of mesoporous materials, including SBA-15. ... An important characteristic of poloxamer solutions is their temperature dependent self-assembling and thermo-gelling behavior. ...
About POLOXAMER 184: Poloxamer 184 is a polyoxyethylene, polyoxypropylene block polymer.. Function(s): Surfactant - Cleansing ...
Poloxamer 407 is a hydrophilic non-ionic surfactant of the more general class of copolymers known as poloxamers. Poloxamer 407 ... reported that aqueous solutions of poloxamer 188 and poloxamer 407 sonicated in the presence or absence of multi-walled carbon ... There is a research ongoing for using poloxamer 407 for aligning severed blood vessels before gluing them surgically. Poloxamer ... They gave a high dose (1 gram per kilogram of body weight) of poloxamer 407 to mice, which blocked 80% of the pores in liver ...
More information is available on poloxamer including side effects, age restrictions, food interactions, whether the medicine is ... Active ingredient: poloxamer. The medicines below all contain the following active ingredient(s): poloxamer. You can select a ...
... *Download PDF Copy ... "Thats where poloxamer 188 comes in," Metzger adds. "It assists the heart to be more compliant during the relaxation phase - ... According to Joseph M. Metzger, Ph.D., the U-M scientist who directed the research, poloxamer 188 can insert itself into small ... When U-M scientists repeated the stretch test after bathing both types of cells with a solution of poloxamer 188, they found ...
Poloxamers (Poloxamer 101, Poloxamer 105, Poloxamer 108, Poloxamer 122, Poloxamer 123, Poloxamer 124, Poloxamer 181, Poloxamer ... Poloxamer 334, Poloxamer 335, Poloxamer 338, Poloxamer 401, Poloxamer 402, Poloxamer 403, Poloxamer 407, Poloxamer 105 Benzoate ... Poloxamer 184, Poloxamer 185, Poloxamer 188, Poloxamer 212, Poloxamer 215, Poloxamer 217, Poloxamer 231, Poloxamer 234, ... Poloxamer 235, Poloxamer 237, Poloxamer 238, Poloxamer 282, Poloxamer 284, Poloxamer 288, Poloxamer 331, Poloxamer 333, ...
Evaluating antibiotics for use in medicine using a poloxamer biofilm model.. Clutterbuck AL1, Cochrane CA, Dolman J, Percival ... The findings of this experiment suggest that poloxamer gel could be used as an appropriate medium on which to conduct biofilm ... Similar outer membrane proteins [OMPs] were identified in bacteria grown in a biofilm state and on a 30% poloxamer hydrogel, ... Diffusion distances of various antibiotics through agar and 30% poloxamer showed no significant difference [P , 0.05]. ...
Buy Poloxamer 407 - CAS Number 9003-11-6 from LGC Standards. Please login or register to view prices, check availability and ...
Pharmacokinetics of moxifloxacin in rabbits after intravenous, subcutaneous and a long-acting poloxamer 407 gel formulation ... administration routes as well as a SC long-acting poloxamer 407 gel formulation (SC-P407). Moxifloxacin concentrations were ...
Poloxamer is biocompatible and the results support the possibility of using Poloxamer gel as a sustained release injectable ...
... poloxamer 188) Injection is a nonionic surfactant with hemorrheologic properties that suggest it may be useful in treating ... RheothRx (poloxamer 188) injection for the acute painful episode of sickle cell disease: a pilot study Blood. 1997 Sep 1;90(5): ... RheothRx (Glaxo Wellcome Inc, Research Triangle Park, NC; poloxamer 188) Injection is a nonionic surfactant with hemorrheologic ... placebo-controlled pilot study to evaluate the safety and efficacy of poloxamer, formulated as RheothRx Injection, in 50 ...
... Bei der Büchersuchmaschine eurobuch.com können Sie ... Evaluation of HPMC and Poloxamer in Curcumin Floating Microspheres: The Goddess of curcumin gives color to life !!!! Focussing ... Evaluation of HPMC and Poloxamer in Curcumin Floating Microspheres: Polymer influence on release kinetics of curcumin. - ... Evaluation of HPMC and Poloxamer in Curcumin Floating Microspheres: Polymer influence on release kinetics of curcumin. - ...
Phase III Randomized Study of Poloxamer 188 for Vaso-Occlusive Crisis of Sickle Cell Disease. The safety and scientific ... Patients receive poloxamer 188 or placebo by continuous infusion for 48 hours. Pain is assessed before, during, and after ... OBJECTIVES: I. Assess the efficacy of poloxamer 188 in reducing the duration of painful vaso-occlusive crisis in patients with ... Assess the effect of poloxamer 188 on duration and intensity of pain, total analgesic use, and length of hospitalization of ...
Effects of Transplanted Heparin-Poloxamer Hydrogel Combining Dental Pulp Stem Cells and bFGF on Spinal Cord Injury Repair ... Effects of Transplanted Heparin-Poloxamer Hydrogel Combining Dental Pulp Stem Cells and bFGF on Spinal Cord Injury Repair. ...
... poloxamer lecithin organogel. Franz cells were utilized for both the release and penetration studies. Semi-permeable dialysis ... The Release and Transdermal Penetration of Baclofen Formulated in a Poloxamer Lecithin Organogel. Arnold John J, Asbill Scott ... The amount of baclofen released by the poloxamer lecithin organogel was linear up to 12 hours. Approximately 20% of applied ... Effect of Formulation pH on Transdermal Penetration of Antiemetics Formulated in Poloxamer Lecithin Organogel. Woodall Rachel, ...
... trial of poloxamer 188 in 255 children and adults with sickle pleted. The company that funded the trial, Mast Therapeu- cell ... Research Editors Note Poloxamer 188 for Sickle Cell Disease Editors Note Jody Zylke, MD Although effective treatments exist ... Poloxamer 188 for Sickle Cell Disease. Poloxamer 188 for Sickle Cell Disease Zylke, Jody 2021-04-20 00:00:00 Research Editors ... Poloxamer 188 for Sickle Cell Disease. Abstract. Research Editors Note Poloxamer 188 for Sickle Cell Disease Editors Note ...
Background: MST-188 (purified poloxamer 188) is a rheologic and membrane stabilizing agent shown to improve LV function in ... Abstract 13191: Short (2 hour) Intravenous Infusion of Purified Poloxamer-188 (MST-188) Elicits Prolonged (1-2 weeks) ... Abstract 13191: Short (2 hour) Intravenous Infusion of Purified Poloxamer-188 (MST-188) Elicits Prolonged (1-2 weeks) ... Abstract 13191: Short (2 hour) Intravenous Infusion of Purified Poloxamer-188 (MST-188) Elicits Prolonged (1-2 weeks) ...
Ex-vivo intestinal absorption study of boswellic acid, cyclodextrin complexes and poloxamer solid dispersions using everted gut ... and poloxamer solid dispersion (PXM SDs) formulations. Absorption studies were performed using the everted gut sac model ...
Poloxamer 407 as a bacterial adhesive for hydrogel contact lenses. J Biomed Mater Res. 1994;28:303-309. [CrossRef] [PubMed] ... The use of poloxamer instead of dextran may make it possible to eliminate this solution and to observe the endothelium in ... At the end of storage and deswelling, total cell loss was 8.8% (99% CI, 5.0-12.6) in the ACF+poloxamer group against 36.2% (99 ... Left: storage in ACF medium (D2 and D30) with deswelling in poloxamer. Right: storage in FCS medium (D2 and D30) with ...
Poloxamer 407-treated mice revealed significant hyperlipidemia, moderately elevated blood pressure, general lipidosis in liver ... Similar to humans, the onset of atherosclerosis in poloxamer 407-treated mice was characterized by a steady increase in serum ... Mice were administered either sterile saline or poloxamer 407 (to induce a dose-controlled hyperlipidemia) for 1 month and then ... Since most of the cellular, biochemical and physiological changes documented in the present study using poloxamer 407-treated ...
Poloxamer-based in situ gelling thermoresponsive systems for ocular drug delivery applications. / Soliman, Karim; Jones, David ... Poloxamer-based in situ gelling thermoresponsive systems for ocular drug delivery applications. In: Drug Discovery Today. 2019. ... Poloxamer-based in situ gelling thermoresponsive systems for ocular drug delivery applications. Drug Discovery Today. 2019 Jun ... Poloxamer- based ocular products have already found their way to the pharmaceutical market, but remain a potential arena for ...
2009). Poloxamer 407 increases soluble adhesion molecules, ICAM-1, VCAM-1, and E-selectin, in C57BL/6 mice. J Pharm Pharmacol ... Effect of poloxamer 407 administration on the serum lipids profile, anxiety level and protease activity in the heart and liver ... 2010). Poloxamer 407 as a general lipase inhibitor: its implications in lipid metabolism and atheroma formation in C57BL/6 mice ... 1998). Poloxamer 407-induced atherogenesis in the C57BL/6 mouse. Atherosclerosis 136: 115-123. ...
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... Ingredient: fr:poloxamer-184 Additive: E1520 - Propylene Glycol ...
Poloxamer 188. Følgende præparater indeholder Poloxamer 188: Præparater, der ikke fremgår af listen, kan indeholde Poloxamer ...
title = "Effects of poloxamer 188 on human PMN cells",. abstract = "Background: Poloxamer 188 (P188), a nonionic block ... Effects of poloxamer 188 on human PMN cells. Matthew T. Harting, Fernando Jimenez, Rosemary A. Kozar, Frederick A. Moore, David ... Effects of poloxamer 188 on human PMN cells. / Harting, Matthew T.; Jimenez, Fernando; Kozar, Rosemary A.; Moore, Frederick A. ... Harting, MT, Jimenez, F, Kozar, RA, Moore, FA, Mercer, DW, Hunter, RL, Cox, CS & Gonzalez, EA 2008, Effects of poloxamer 188 ...
Dantron and Poloxamer 188. Pinorax, 5mg dantron + 40 mg poloxamer 188 per mL oral suspension and 15mg dantron + 200 mg ... poloxamer 188 per mL oral suspension. AFT Pharmaceuticals Limited. Consent is given subject to the following restriction:. ...
Parabulbar Use of Poloxamer for Controlled Drug Release You will receive an email whenever this article is corrected, updated, ... Results: : The gelation temperature of the 25 % Poloxamer formulation is 19oC and the gel dissolves in six hours in vitro. In ... Conclusions: : Parabulbar injection of Poloxamer will give a release of compounds like FITC-Dextran for at least 12 hours. ... Methods: : Young Wistar rats were anesthetised before parabulbar injection of Poloxamer (25 % in 0.9 % NaCl with or without 0.1 ...
Corning™ Poloxamer 188, 10% Solution. Acts as surfactant used in cell culture to protect cells in suspension against possible ...
  • Poloxamer 407 is a hydrophilic non-ionic surfactant of the more general class of copolymers known as poloxamers. (wikipedia.org)
  • Most of the common uses of poloxamer 407 are related to its surfactant properties. (wikipedia.org)
  • poloxamer 188) Injection is a nonionic surfactant with hemorrheologic properties that suggest it may be useful in treating acute painful episodes (vasoocclusive crises) of sickle cell disease (SCD). (nih.gov)
  • Background: Poloxamer 188 (P188), a nonionic block copolymer chemical surfactant known to have cytoprotective, rheologic, anti-inflammatory, and anti-thrombotic activity, has shown promise in the management of selected trauma patients. (nebraska.edu)
  • Specialized for use in insect cell culture Poloxamer 188 is a surfactant used in cell culture to protect cells in suspension against possible damage during transfer, freezing and thawing, and stirring. (thomassci.com)
  • Recently, the non-ionic surfactant poloxamer 188 (P188) has been shown to reduce by approximately 50% the percentage of non-viable chondrocytes 24 hours post injury in chondral explants exposed to 25 MPa of unconfined compression. (msu.edu)
  • poloxamer) copolymers, which are surfactant substances comprising two hydrophilic poly(ethylene oxide) (PEO) and one hydrophobic poly(propylene oxide) (PPO) areas arranged in a PEOCPPOCPEO triblock structure. (researchensemble.com)
  • This study was aimed at preparing, characterising and evaluating in situ gel formulations based on a blend of two hydrophilic polymers i.e. poloxamer 407 (P407) and poloxamer 188 (P188) for a sustained ocular delivery of ketorolac tromethamine (KT). (kingston.ac.uk)
  • We have thus evaluated this phenomenon for RBC aggregated by several water-soluble polymers, using poloxamer 188 (P188), a non-ionic, tri-block molecule (total molecular mass of 8.40 kDa, 80% polyoxyethylene). (elsevier.com)
  • Poloxamer 188 (P188) is a nonionic triblock copolymer believed to prevent cellular injury after ischemia and reperfusion. (onlinejacc.org)
  • 4 ]. A particular chemically-induced mouse model of hyperlipidemia and atherosclerosis involves the chronic administration of a block copolymer called poloxamer 407 (P-407) to mice of either sex. (biomedcentral.com)
  • Chronic administration of the poloxamer 407 (P-407), a block copolymer, to elevate serum lipids in mice is a well-established mouse model of hyperlipidemia and atherosclerosis. (sciendo.com)
  • OBJECTIVES: I. Assess the efficacy of poloxamer 188 in reducing the duration of painful vaso-occlusive crisis in patients with sickle cell disease. (clinicaltrials.gov)
  • reported that aqueous solutions of poloxamer 188 and poloxamer 407 sonicated in the presence or absence of multi-walled carbon nanotubes (MWNTs) can become highly toxic to cultured cells. (wikipedia.org)
  • Methods: Phase solubility behavior of coenzyme Q10 at 25ËšC in various molar solutions of poloxamer 407 in water was observed and their binary solid dispersions at different weight ratios were prepared. (fip.org)
  • The findings of this experiment suggest that poloxamer gel could be used as an appropriate medium on which to conduct biofilm antibiotic susceptibility tests as it enables bacteria to be grown in a state representative of the infected surface from which the culture was taken. (nih.gov)
  • Based upon the depletion model for polymer-induced aggregation, these findings suggest that poloxamer 188 acts by penetrating the depletion layer near the glycocalyx, thereby reducing the osmotic gradient between the intercellular gap and the suspending medium. (elsevier.com)
  • Pharmacokinetics of moxifloxacin in rabbits after intravenous, subcutaneous and a long-acting poloxamer 407 gel formulation administration. (nih.gov)
  • The pharmacokinetics (PK) of moxifloxacin in healthy white New Zealand rabbits was studied following intravenous (IV) and subcutaneous (SC) administration routes as well as a SC long-acting poloxamer 407 gel formulation (SC-P407). (nih.gov)
  • Poloxamer is biocompatible and the results support the possibility of using Poloxamer gel as a sustained release injectable formulation. (ovid.com)
  • The gelation temperature of the 25 % Poloxamer formulation is 19 o C and the gel dissolves in six hours in vitro. (arvojournals.org)
  • 8. The oral formulation according to claim 1 wherein the oral composition additionally comprises a poloxamer. (google.es)
  • The optimized formulation of second-generation nanocrystals with concentrations 0.75% w/v poloxamer 188 and 2% w/v PLGA, could produce particle size of 114.6 nm, entrapment efficiency of 63.48% and drug release 80.23% at 12 h. (nanobe.org)
  • In a 30% solution by weight, poloxamer 407 forms a gel solid at room temperature but liquifies when chilled to 4 °C (39 °F). This allows poloxamer 407 to serve as a removable support material, particularly for creating hollow channels or cavities inside hydrogels. (wikipedia.org)
  • The following tracks 2, 3 and 4 reveal the proteins from the planktonic culture grown on Mueller Hinton agar, the poloxamer hydrogels made from Mueller Hinton broth and the biofilm culture from the microtitre plate respectively. (nih.gov)
  • P407 = poloxamer with a polyoxypropylene molecular mass of 4000 g/mo} and a 70% polyoxyethylene content). (wikipedia.org)
  • Poloxamer 407 (P407) thermo-sensitive hydrogel formulations were developed to enhance the retention time in the urinary bladder after intravesical instillation . (bvsalud.org)
  • The present study, hence, deals in enhancement of the intestinal absorption of AKBA from total boswellic acid fraction (TA fraction) using cyclodextrin (CD) and poloxamer solid dispersion (PXM SDs) formulations. (nih.gov)
  • Rheological measurements were evaluated to confirm the critical gelation temperature (CGT) of the poloxamer formulations with or without fluorescein sodium (FS), as a model drug, at various concentrations. (qub.ac.uk)
  • Optimized poloxamer formulations were subjected to in vitro release studies using a vial method. (qub.ac.uk)
  • Finally, the in vitro delivery of FS from optimized poloxamer formulations was conducted across non-porated vs microporated skin samples using vertical Franz diffusion cells. (qub.ac.uk)
  • Results concluded that permeation of FS was sustained for 96 h across the MN-treated skin samples containing in situ forming depot poloxamer formulations compared to non-microporated skin which sustained the FS delivery for 72 h. (qub.ac.uk)
  • The present research work was planned to formulate poloxamer 407 based hydrogel formulations of metronidazole and the evaluation of various parameters like swelling behavior, drug PH stability, in-vitro and in-vivo drug release, and in-vitro cytotoxic activity. (ijpsr.com)
  • Two different concentrations of metronidazole hydrogel formulations were prepared using poloxamer 407 and were assessed by a validated HPLC method for drug content, pH stability, and in-vivo drug release. (ijpsr.com)
  • For the generic term poloxamer, these copolymers are commonly named with the letter P (for poloxamer) followed by three digits: the first two digits multiplied by 100 give the approximate molecular mass of the polyoxypropylene core, and the last digit multiplied by 10 gives the percentage polyoxyethylene content (e.g. (wikipedia.org)
  • Soliman, K , Jones, D & Thakur, R 2019, ' Poloxamer-based in situ gelling thermoresponsive systems for ocular drug delivery applications ', Drug Discovery Today . (qub.ac.uk)
  • In this study, for the first time, we have reported a sustained transdermal drug delivery from thermoresponsive poloxamer depots formed within the skin micropores following microneedle (MN) application. (qub.ac.uk)
  • The methanolic partitionate of pet ether extract of flowers of Punica granatum (Family: Punicaceae) was evaluated for antihyperlipidemic activity in poloxamer 407 induced hyperlipidemic mice. (phcogfirst.com)
  • Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol (PEG). (wikipedia.org)
  • The effects of poloxamer 188, amphiphilic triblock copolymer on carrier particle size, surface morphology, polydispersity index, zeta potential, drug entrapment efficiency and drug release of nanoformulation were investigated. (nanobe.org)
  • Furthermore, the sol -gel transition temperature, mucoadhesive properties, and drug release profiles of poloxamer-based in situ gels can be finely tuned, enabling them to be used as vehicles for the delivery of small and large drug molecules to treat diseases of the anterior and posterior segments of the eye. (qub.ac.uk)
  • Thermo-modulated in-situ hydrogel (TSHG) are formulated routinely utilizing poloxamer for extended drug release. (jddtonline.info)
  • The purpose of the present study was to fabricate biodegradable chitosan-poloxamer-based in-situ drug delivery systems and assessment of their physical properties. (jddtonline.info)
  • Aim: To Improve the solubility and in vitro dissolution of Coenzyme Q10 from binary solid dispersions using poloxamer 407. (fip.org)
  • Poloxamer 407 is a triblock polymer that exhibits concentration-dependent reverse thermal gelation, in which aqueous solutions are liquid at low temperatures (-10°C) and form semisolid gels at body temperature. (biomedcentral.com)
  • Will receive 0.1 ml prepared Simvastatin in 1.2% (W/V) Lecithin/isopropyl palmitate solution (Lipoil®), Poloxamer 407 gel (Polox Gel 20%®) applied topically into the peri-implant gingival sulcus using a plastic syringe with a blunt cannula. (clinicaltrials.gov)
  • Short-term intravenous doses up to 4 g/kg of Poloxamer 108 produced no change in body weights, but did result in diffuse hepatocellular vacuolization, renal tubular dilation in kidneys, and dose-dependent vacuolization of epithelial cells in the proximal convoluted tubules. (cosmeticsinfo.org)
  • Intervention: Patients were randomly assigned to receive an intravenous infusion of purified poloxamer 188, 100 mg/kg for 1 hour followed by 30 mg/kg per hour for 47 hours (n=127), or a matching volume of saline placebo (n=128). (elsevier.com)
  • P123/N127 (poloxamer) combined micelles for the intravenous delivery of the anticancer drug sorafenib (SRB) or its combination with verteporfin (VP), a photosensitizer for photodynamic therapy that should go with well the cytotoxicity profile of the chemotherapeutic. (researchensemble.com)
  • Furthermore, drug-loaded poloxamer micelles can passively target tumors by the enhanced permeability and retention (EPR) effect after intravenous injection. (researchensemble.com)
  • They gave a high dose (1 gram per kilogram of body weight) of poloxamer 407 to mice, which blocked 80% of the pores in liver cells that absorb lipoproteins, leading to a 10-fold increase in plasma lipid levels. (wikipedia.org)
  • The chemical sealant that protected hearts in dystrophic mice from damage is called poloxamer 188. (news-medical.net)
  • The aims of this study were to evaluate the effect of poloxamer 407 administration on atherogenic serum lipoprotein fractions and sub fractions associated with cholesterol, triglycerides and phospholipids, as well as the onset of early atherosclerosis, in mice. (biomedcentral.com)
  • Mice were administered either sterile saline or poloxamer 407 (to induce a dose-controlled hyperlipidemia) for 1 month and then sacrificed at 1, 4 and 10 days after the last dose of poloxamer 407. (biomedcentral.com)
  • Poloxamer 407-treated mice revealed significant hyperlipidemia, moderately elevated blood pressure, general lipidosis in liver cells, increased cysteine protease activity in heart tissue, and contractile-type changes in cardiomyocytes. (biomedcentral.com)
  • Similar to humans, the onset of atherosclerosis in poloxamer 407-treated mice was characterized by a steady increase in serum low-density, intermediate-density and very-low-density lipoprotein fractions, as well as very-low-density lipoprotein sub fractions. (biomedcentral.com)
  • We would propose that the sustained elevation of serum atherogenic lipoprotein fractions and sub fractions induced by the administration of poloxamer 407 to mice resulted in the morphological changes we observed in both heart and liver cells, which are suggested to precede atherosclerosis, since this is a well-established mouse model of atherosclerosis. (biomedcentral.com)
  • Since most of the cellular, biochemical and physiological changes documented in the present study using poloxamer 407-treated mice are related to the symptoms of early atherosclerosis in humans, it is suggested that the poloxamer 407-induced mouse model of hyperlipidemia and atherosclerosis might prove beneficial as an experimental animal model with which to evaluate the pathological features observed in early-stage atherosclerosis. (biomedcentral.com)
  • Following 14 weeks of poloxamer 407 treatment, mice developed atherosclerosis and the plasma concentrations of monomethylarginine and asymmetric dimethylarginine were found to be significantly greater than corresponding concentrations in control mice. (houstonmethodist.org)
  • This finding may have contributed to the development of aortic atherosclerotic lesions in poloxamer-treated mice by interfering with nitric oxide availability and, hence, normal function of vascular endothelium. (houstonmethodist.org)
  • Poloxamer-407-treated mice also showed a significant decrease in locomotor and exploratory activity, together with signs of emotional stress and anxiety relative to controls. (houstonmethodist.org)
  • Thus, it is also suggested that the increase in both plasma monomethylarginine and asymmetric dimethylarginine in poloxamer-407-treated mice may somehow influence learning and memory, because endothelial dysfunction caused by reduced nitric oxide availability has been hypothesized to negatively influence cognitive function. (houstonmethodist.org)
  • Poloxamer 188 with three different concentrations (0.5, 0.75, 1% w/v) in combination with PLGA at 1, 2, 3% concentrations (w/v) successfully produced MHc loaded PLGA second generation nanocrystals. (nanobe.org)
  • The purpose of this study was to evaluate the in vitro release and ex vivo penetration of baclofen following incorporation into a 2% poloxamer lecithin organogel. (ijpc.com)
  • Results demonstrated that baclofen release from the poloxamer lecithin organogel was significantly higher than its penetration through porcine skin. (ijpc.com)
  • The amount of baclofen released by the poloxamer lecithin organogel was linear up to 12 hours. (ijpc.com)
  • The word poloxamer was coined by BASF inventor, Irving Schmolka, who received the patent for these materials in 1973. (wikipedia.org)
  • This study was undertaken to demonstrate the suitability of Poloxamer 407 (BASF) for parabulbar injections and controlled drug release. (arvojournals.org)
  • The medicines below all contain the following active ingredient(s): poloxamer. (healthdirect.gov.au)
  • Poloxamer 188 became a standard ingredient in cell culture media for commercial production as an effective tool in protecting against shear. (cellculturedish.com)
  • The hydroalcoholic lacquer, elaborated with cyclodextrin/poloxamer soluble polypseudorotaxane and sodium lauryl sulfate as an enhancer, allowed the rate of diffusion and penetration of the active ingredient within the nail to be significantly higher than obtained with the reference lacquers when using either ciclopirox olamine or clobetasol propionate as the active ingredient. (bath.ac.uk)
  • Previous reports have suggested that non-ionic poloxamer surfactants of appropriate molecular mass and composition can reduce red blood cell (RBC) aggregation in whole blood and in RBC-plasma suspensions. (elsevier.com)
  • In this study, we employed a mixture of the surfactants poloxamer 407 with sodium caprate to produce a solid dispersion containing ursolic acid aimed at enhancing both drug dissolution and in vivo trypanocidal activity. (bvsalud.org)
  • Binary and ternary systems comprising the photosensitizer 5, 10, 15, 20-tetrakis(4-hydroxyphenyl)porphyrin (THPP), poloxamer 407 and the β-cyclodextrin (βCD)-derivatives hydroxypropylβCD (HPβCD), methylβCD (MβCD) and heptakisβCD (HkβCD) were prepared. (ndsl.kr)
  • Research design and methods In this study, a poloxamer 407 thermosensitive hydrogel loaded with KGF-2 and/or FGF-21 was prepared and its physical and biological properties were characterized. (bmj.com)
  • We recently published a Cool Tool, " Improved, High Quality Poloxamer 188 Produces Consistent Performance in Cell Culture , " that discusses how MilliporeSigma addressed this issue by developing proprietary analytical and biological methods to identify the critical properties of Poloxamer 188. (cellculturedish.com)
  • We conducted a randomized, double-blind, placebo-controlled pilot study to evaluate the safety and efficacy of poloxamer, formulated as RheothRx Injection, in 50 patients with SCD. (nih.gov)
  • Young Wistar rats were anesthetised before parabulbar injection of Poloxamer (25 % in 0.9 % NaCl with or without 0.1 % FITC-Dextran 20). (arvojournals.org)
  • Parabulbar injection of Poloxamer will give a release of compounds like FITC-Dextran for at least 12 hours. (arvojournals.org)
  • Characterization of rabies pDNA nanoparticulate vaccine in poloxamer 407 gel. (cdc.gov)
  • Poloxamer 184 is a polyoxyethylene, polyoxypropylene block polymer. (ewg.org)
  • For example, the smallest polymer, Poloxamer 101, consists of a block with an average of 2 units of polyoxyethylene, a block with an average of 16 units of polyoxypropylene, followed by a block with an average of 2 units of polyoxyethylene. (cosmeticsinfo.org)
  • Patients are randomized to treatment poloxamer 188 or placebo. (clinicaltrials.gov)
  • Patients receive poloxamer 188 or placebo by continuous infusion for 48 hours. (clinicaltrials.gov)
  • The neutral results phase 3 multicenter, randomized, placebo-controlled clinical of the study were announced in 2016 when the trial was com- trial of poloxamer 188 in 255 children and adults with sickle pleted. (deepdyve.com)
  • Objective: To compare the duration of painful episodes in patients with SCD treated with purified poloxamer 188 to that of similar episodes experienced by patients who receive a placebo. (elsevier.com)
  • Results: Mean (SD) duration of the painful episodes was 141 (42) hours in the placebo group compared with 133 (41) hours in those treated with purified poloxamer 188, a 9-hour reduction (P=.04). (elsevier.com)
  • Conclusions: A decrease in the duration of painful episodes and an increase in the proportion of patients who achieved resolution of the symptoms were observed when the purified poloxamer 188-treated patients were compared with the patients receiving placebo. (elsevier.com)
  • The nanoplexes had a positive zeta potential, and low amounts of PLGA and poloxamer 188 showed a mean colloidal size of ~200 nm with a polydispersity index of ~0.14. (dovepress.com)
  • Use of low amounts of PLGA and poloxamer 188 enabled development of a nanosphere able to transfect cells efficiently. (dovepress.com)
  • In conclusion, the study emphasizes that poloxamer 188 was a versatile excipient, which played a pivotal role in producing nanosize carrier with high drug release profile of MHc loaded PLGA nanosuspensions of second generation nanocrystals. (nanobe.org)
  • Besides the obvious advantage of delivering SRB in poloxamer micelles, our results provide a obvious example that each photochemotherapeutic combination needs detailed research on their particular connection, and no generalization on enhanced cytotoxic effects should become produced a priori. (researchensemble.com)
  • Poloxamer unimers have also shown the ability to hypersensitize multidrug-resistant cells by inhibiting glycoprotein P-mediated drug efflux.4,5 Mixed micelles made of more than one type of Pluronic? (researchensemble.com)
  • Outer Membrane Protein analysis was performed on E.coli, Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabilis and Acinetobacter juni when grown on Mueller Hinton agar ('quasi-biofilm state') and 30% Poloxamer hydrogel ('true- biofilm state). (nih.gov)
  • Similar outer membrane proteins [OMPs] were identified in bacteria grown in a biofilm state and on a 30% poloxamer hydrogel, which were very different to the OMPs identified in bacteria grown on Mueller-Hinton agar and broth. (nih.gov)
  • MST-188 (purified poloxamer 188) is a rheologic and membrane stabilizing agent shown to improve LV function in animals with experimental myocardial infarction or with dystrophin deficiency. (ahajournals.org)
  • A short-term inhalation toxicity study of Poloxamer 101 in air at 97 mg/m3 identified slight alveolitis after two weeks of exposure which subsided in the 2 week post-exposure observation period. (cosmeticsinfo.org)
  • A short-term dermal toxicity study of Poloxamer 184 at doses up to 1000 mg/kg produced slight erythema and slight intradermal inflammatory response in histological examination, but no dose-dependent body weight, hematology, blood chemistry, or organ weight changes. (cosmeticsinfo.org)
  • Based on the clinical and histopathological evaluation Poloxamer seem to be avoid of local toxicity. (arvojournals.org)
  • Poloxamer 407 is used in bioprinting applications due to its unique phase-change properties. (wikipedia.org)
  • The photosensitizer remained as a CD-inclusion complex in ternary systems containing MβCD while it seemed to be located in the poloxamer phase in the presence of HkβCD or HPβCD. (ndsl.kr)
  • An important characteristic of poloxamer solutions is their temperature dependent self-assembling and thermo-gelling behavior. (wikipedia.org)
  • Results also showed that SLN increase erosion rate of Poloxamer gel and its sol-gel transition temperature. (ijps.ir)
  • Purified poloxamer 188 may increase tissue oxygenation and thereby reduce inflammation, pain, and the overall duration of such painful episodes in patients with SCD. (elsevier.com)
  • Meiselman, H. J. / Inhibition of polymer-induced red blood cell aggregation by poloxamer 188 . (elsevier.com)
  • Stiffness in the case of the repair with Poloxamer 407 group was significantly higher than that in the repair with collagen sponge group. (biomedcentral.com)
  • Results A 17.0% (w/w) poloxamer 407 combined with 1.0% (w/w) glycerol exhibited controlled release characteristics and a three-dimensional structure. (bmj.com)
  • Fourier Transform Infrared Spectroscopy results showed hydrogen bonding intermolecular interactions between drug and poloxamer 407 . (bvsalud.org)
  • A 6 month feeding study of Poloxamer 188 at exposures up to 5% in the diet produced no adverse effects. (cosmeticsinfo.org)
  • Poloxamer 188 at levels up to 7.5% in diet in a 2 year feeding study produced diarrhea at 5% and 7.5% levels, a small decrease in growth at the 7.5% level, but no change in survival. (cosmeticsinfo.org)
  • This study was an assessment of a new animal compound-free (ACF) medium for corneal storage and of its combination with poloxamer for end-of-storage corneal deswelling. (arvojournals.org)
  • Objective The present study focused on the development of a poloxamer 407 thermosensitive hydrogel loaded with keratinocyte growth factor-2 (KGF-2) and fibroblast growth factor-21 (FGF-21) as a therapeutic biomaterial in a scald-wound model of type-2 diabetes in Goto-Kakizaki (GK) rats. (bmj.com)
  • In this study, we investigated the effects of Poloxamer 407 as a carrier vehicle on rotator cuff healing at the repair site and compared it with those of a collagen sponge, which is a commonly used carrier vehicle. (biomedcentral.com)
  • In this study, a double network hydrogel of a natural polysaccharide gellan gum (GG) hydrogel and a synthetic hydrogel poloxamer-heparin (PoH) hydrogel (PoH/GG DNH) is introduced to complement disadvantages of each hydrogel and improve the microenvironment for cell delivery. (uminho.pt)
  • Poloxamer 188 is also approved for use as an antibacterial agent in Over-the-Counter (OTC) skin wound cleanser drug products. (cosmeticsinfo.org)
  • Poloxamer- based ocular products have already found their way to the pharmaceutical market, but remain a potential arena for further investigation and commercial exploitation. (qub.ac.uk)
  • When U-M scientists repeated the stretch test after bathing both types of cells with a solution of poloxamer 188, they found that it restored the ability of mdx myocytes to handle a 20 percent stretch without damage or increased levels of calcium. (news-medical.net)
  • Poloxamer 188 at 5 mg/ml was more effective with younger, less-dense cells. (elsevier.com)
  • Poloxamer 188 is commonly used in the biopharmaceutical industry as a cell culture media additive to protect cells from the turbulent environment of sparged bioreactors. (cellculturedish.com)
  • Yes, Poloxamer 188 in seed trains is needed to adapt the cells to the media composition and to protect the cells from shear. (cellculturedish.com)
  • This innovative use of poloxamer for deswelling appears far less toxic than does dextran. (arvojournals.org)
  • Assess the effect of poloxamer 188 on duration and intensity of pain, total analgesic use, and length of hospitalization of these patients. (clinicaltrials.gov)
  • Effect of poloxamer 40. (sciendo.com)
  • Conclusions A KGF-2/FGF-21 poloxamer hydrogel accelerated wound healing of scalded skin in GK rats, which was attributed to a synergistic effect of KGF-2-mediated cellular proliferation and FGF-21-mediated inhibition of inflammatory responses. (bmj.com)
  • Susceptibility to antibiotics on 28 clinical isolates was determined using the modified Kirby Bauer disc diffusion method, on agar and 30% Poloxamer. (nih.gov)
  • The average diffusion distances of various antibiotics through standard agar and 30% Poloxamer gels. (nih.gov)