Jaagsiekte sheep retrovirus
Pulmonary Surfactant-Associated Protein A
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Pulmonary Adenomatosis, Ovine
Pulmonary Surfactant-Associated Proteins
Pulmonary Surfactant-Associated Protein B
Plutonium. A naturally radioactive element of the actinide metals series. It has the atomic symbol Pu, atomic number 94, and atomic weight 242. Plutonium is used as a nuclear fuel, to produce radioisotopes for research, in radionuclide batteries for pacemakers, and as the agent of fission in nuclear weapons.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
Pulmonary Surfactant-Associated Protein C
A pulmonary surfactant associated protein that plays a role in alveolar stability by lowering the surface tension at the air-liquid interface. It is a membrane-bound protein that constitutes 1-2% of the pulmonary surfactant mass. Pulmonary surfactant-associated protein C is one of the most hydrophobic peptides yet isolated and contains an alpha-helical domain with a central poly-valine segment that binds to phospholipid bilayers.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Lung Diseases, Interstitial
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.
Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.
Severe Acute Respiratory Syndrome
Specific Pathogen-Free Organisms
Respiratory Distress Syndrome, Adult
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Bronchoalveolar Lavage Fluid
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Disease Models, Animal
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Reverse Transcriptase Polymerase Chain Reaction
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. (1/191)(+info)
Oxidative stress and inflammation response after nanoparticle exposure: differences between human lung cell monocultures and an advanced three-dimensional model of the human epithelial airways. (2/191)(+info)
Optimization of Streptomyces bacteriophage phi C31 integrase system to prevent post integrative gene silencing in pulmonary type II cells. (3/191)(+info)
Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells. (4/191)(+info)
An impaired alveolar-capillary barrier in vitro: effect of proinflammatory cytokines and consequences on nanocarrier interaction. (5/191)(+info)
Modulation of epithelial sodium channel activity by lipopolysaccharide in alveolar type II cells: involvement of purinergic signaling. (6/191)(+info)
Micro-RNA-375 inhibits lung surfactant secretion by altering cytoskeleton reorganization. (7/191)(+info)
Muscarinic receptor-mediated bronchoconstriction is coupled to caveolae in murine airways. (8/191)(+info)
Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis - Libre Pathology
2.0 2.1 2.2 2.3 2.4 Kobashi, Y.; Sugiu, T.; Mouri, K.; Irei, T.; Nakata, M.; Oka, M. (Jun 2008). Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis: differentiation from multiple atypical adenomatous hyperplasia.. Jpn J Clin Oncol 38 (6): 451-4. doi:10.1093/jjco/hyn042. PMID 18535095. ...
State-dependent inactivation of K+ currents in rat type II alveolar epithelial cells. | JGP
Inactivation of K+ channels responsible for delayed rectification in rat type II alveolar epithelial cells was studied in Ringer, 160 mM K-Ringer, and 20 mM Ca-Ringer. Inactivation is slower and less complete when the extracellular K+ concentration is increased from 4.5 to 160 mM. Inactivation is faster and more complete when the extracellular Ca2+ concentration is increased from 2 to 20 mM. Several observations suggest that inactivation is state-dependent. In each of these solutions depolarization to potentials near threshold results in slow and partial inactivation, whereas depolarization to potentials at which the K+ conductance, gK, is fully activated results in maximal inactivation, suggesting that open channels inactivate more readily than closed channels. The time constant of current inactivation during depolarizing pulses is clearly voltage-dependent only at potentials where activation is incomplete, a result consistent with coupling of inactivation to activation. Additional evidence for ...
Gereke, M., Jung, S., Buer, J. and Bruder, D. (2009) Alveolar type II epithelial cells present antigen to CD4(1) T cells and...
Gereke, M., Jung, S., Buer, J. and Bruder, D. (2009) Alveolar type II epithelial cells present antigen to CD4(1) T cells and induce Foxp3(1) regula-tory T cells. American Journal of Respiratory and Critical Care Medicine, 179, 344-355. doi10.1164/rccm.200804-592OC
Rapid isolation of type II pneumocytes with magnetic removal of macrophages
A method is described for the rapid preparation of lung cell fractions enriched in type II alveolar pneumocytes. Isolated perfused rabbit lungs are exposed to Fe3O4 by tracheal lavage, which permits pulmonary alveolar macrophages to phagocytize the particles. Alveolar epithelial cells are then selectively freed from the basement membrane matrix by critical placement of collagenase and elastase. Detached cells are harvested either by repeated tracheal lavage or by mincing the lobes and filtering freed cells through a series of nylon mesh sieves. Iron oxide-containing macrophages are then removed from the harvested cells by a strong magnetic field. A final sizing of the macrophage-depleted suspension yields a preparation enriched in alveolar type II cells. Eight million viable cells (95% type II) were obtained per rabbit lung when harvested by lavage, while 32 ± 106 (88% type II) cells were obtained from minced lungs. These values for cell yield and relative purity are comparable to previously ...
JCI - Yap/Taz regulate alveolar regeneration and resolution of lung inflammation
Alveolar epithelium plays a pivotal role in protecting the lungs from inhaled infectious agents. Therefore, the regenerative capacity of the alveolar epithelium is critical for recovery from these insults in order to rebuild the epithelial barrier and restore pulmonary functions. Here, we show that sublethal infection of mice with Streptococcus pneumoniae, the most common pathogen of community-acquired pneumonia, led to exclusive damage in lung alveoli, followed by alveolar epithelial regeneration and resolution of lung inflammation. We show that surfactant protein C-expressing (SPC-expressing) alveolar epithelial type II cells (AECIIs) underwent proliferation and differentiation after infection, which contributed to the newly formed alveolar epithelium. This increase in AECII activities was correlated with increased nuclear expression of Yap and Taz, the mediators of the Hippo pathway. Mice that lacked Yap/Taz in AECIIs exhibited prolonged inflammatory responses in the lung and were delayed in ...
NIOSHTIC-2 Publications Search - 00189546 - Interferon production in rat type II pneumocytes and alveolar macrophages.
Interferon production in rat type-II pneumocytes and alveolar macrophages in response to viral stimulation was examined. Type-II pneumocytes and alveolar macrophages isolated from the lungs of male Sprague-Dawley-rats were inoculated with Ao/PR/8/34 influenza and parainfluenza viruses at virus to cell ratios of 1.0 to 10. They were monitored for interferon production for 48 hours. The products wer
The present study was undertaken to explore at the cellular level possible mechanisms of KGF action susceptible to account for its protective effects toward the exposure of the developing lung to hyperoxia, used as a model of alveolar injury. We report an enhanced rate of alveolar cell wound closure in vitro and maintenance of lung cell content in vivo, likely due to enhanced survival of alveolar epithelial type II cells.. Most studies demonstrating a protective effect of KGF against lung injury have used the intratracheal route (38, 54), rather than the systemic route (6), whereas we administered KGF intraperitoneally and during oxygen exposure. Possible mechanisms to explain the protective effects of KGF in acute lung injury were recently reviewed (57) and are mainly based on effects on alveolar and airway epithelial cells, including increased proliferation (33, 39, 53, 63), increased surfactant production (14, 27, 50, 61), enhanced DNA repair (12, 51, 60), and decreased apoptosis (12, 43). ...
Hepatocyte growth factor (HGF) is a cytokine with pleiotropic functions during wound healing and repair. Its anti-fibrotic effects were shown in animal models of lung fibrosis and linked to improved cellular survival and proliferation and reduced myofibroblast accumulation. HGF-elicited, pro-survival pathways have yet not been investigated in detail in lung epithelial cells. Based on literature, our study is focused on Bcl-xL, prosurvival protein involved in mitochondrial control of apoptosis.. Results: Western blot analysis of IPF lung homogenates revealed significantly increased expression of Bcl-xL when compared to donor lungs, and a similar observation was made in bleomycin versus saline treated murine lungs. In human IPF, much less in donor lungs, Bcl-xL protein is highly expressed in hyperplastic alveolar epithelial type II cells, basal cells, bronchial epithelial ciliated and non-ciliated cells. Furthermore, Bcl-xL expression co-localized with specific HGF receptor cMet. In vitro data ...
Ceramide membrane microdomains regulate cytokine secretion - Brij Singh
Although alveolar epithelial type II cells (AECII) form the barrier of alveolar spaces and produce surfactants to maintain lung integrity, the unique AECII popu...
Homepage - The Respiratory Unit
The Respiratory Unit at the Hospital of St John and St Elizabeth has one of the most revolutionary and innovative centres - dedicated to diagnosing all respiratory disorders.. Staffed by some of the finest physiologists and consultants we offer expert care in a calm and caring environment as well as fast and accurate diagnosis using the latest state-of-the-art equipment.. The highly skilled team specialise in treating conditions such as Asthma, Chronic Obstructive Pulmonary Disease, Sarcoidosis, Interstitial Lung Disease, sleep disordered breathing and allergy. Test results are normally available within 24 hours.. ...
Peripheral papillary tumor of type-II pneumocytes: a rare neoplasm of undetermined malignant potential - Semantic Scholar
Peripheral papillary adenomas of the lung are uncommon neoplasms (only ten cases have been described so far in the English literature) composed predominantly of type-II pneumocytes and generally considered benign. We describe here two additional cases of this lung tumor. In both cases histological examination revealed an encapsulated papillary neoplasm with invasion of the capsule and, in one case, invasion of the adjacent alveoli and visceral pleura too. The proliferative index (Ki67) was less than 2% and the epithelial cells were positive for cytokeratins, surfactant apoproteins (SP), and nuclear thyroid transcription factor-1 (TTF-1). Ultrastructurally, the epithelial cells showed the characteristic surface microvilli and cytoplasmic lamellar inclusions of type-II cells. Review of the literature has revealed two other cases of peripheral papillary adenoma of type-II pneumocytes with infiltrative features. Thus, we propose replacing the term peripheral papillary adenoma with peripheral papillary tumor
Massive bilateral renal angiomyolipomatosis and multifocal micronodular pneumocytes hyperplasia associated with tuberous...
Tuberous sclerosis (TS) is an autosomal-dominant disorder characterized by a variety of hamartomatous lesions in various organs. Various organ …
MICRO EUROPEAN 3.5% FUEL OIL BARGES RDAM MARCH 2025 (NYMEX:QMEF.H25) Future Chart & Quotes - INO.com
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Vacuolar ATPase Regulates Surfactant Secretion in Rat Alveolar Type II Cells by Modulating Lamellar Body Calcium
Lung surfactant reduces surface tension and maintains the stability of alveoli. How surfactant is released from alveolar epithelial type II cells is not fully understood. Vacuolar ATPase (V-ATPase) is the enzyme responsible for pumping H+ into lamellar bodies and is required for the processing of surfactant proteins and the packaging of surfactant lipids. However, its role in lung surfactant secretion is unknown. Proteomic analysis revealed that vacuolar ATPase (V-ATPase) dominated the alveolar type II cell lipid raft proteome. Western blotting confirmed the association of V-ATPase a1 and B1/2 subunits with lipid rafts and their enrichment in lamellar bodies. The dissipation of lamellar body pH gradient by Bafilomycin A1 (Baf A1), an inhibitor of V-ATPase, increased surfactant secretion. Baf A1-stimulated secretion was blocked by the intracellular Ca2+ chelator, BAPTA-AM, the protein kinase C (PKC) inhibitor, staurosporine, and the Ca2+/calmodulin-dependent protein kinase II (CaMKII), KN-62. Baf A1
Notch is an ancient cell-signaling system that regulates the specification of cell fate. Recently, Notch was found to confer antigen presenting cell function on mast cells, induce histamine release in human basophils and regulate migration and survival of eosinophils.. In acute lung injury, alveolar type II cells activate macrophages, secrete soluble mediators, migrate and spread in response to the injury. Additionally, Notch stimulated myofibroblast differentiation and migration of cultured RLE-6TN cells. However, until now, nothing is known on the role of Notch activation regarding proliferation of rat alveolar type II cells.. Rat alveolar type II cells (RLE 6TN) were obtained from the American Type Culture Collection (ATCC no. CRL-2300; Manassas, VA, USA) and were cultured in DMEM/Hams F12 containing 10% fetal calf serum and L-glutamine. Cell proliferation was measured by direct cell count and the fluorometric proliferation assay EZ4U basing on tetrazolium salt reduction. Cells were ...
JCI - Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism
mRNA and AAV vector production. mRNA transcripts were produced as previously described (23). Briefly, a T7 promoter-containing pVAX1 plasmid (Life Technologies) with a 120 bp polyA tail expressing mouse Foxp3 cDNA (CCDS 29965.1) was linearized by XbaI and transcribed in vitro using the mMESSAGE mMACHINE T7 ULTRA kit (Life Technologies), incorporating 10% 2-Thio-UTP and 5-Methyl-CTP (TriLink BioTechnologies). Recombinant AAV2/6.2 vectors expressing either EGFP or Foxp3 were created, as previously described, using plasmids obtained from the Penn Vector Core (24). Vectors were purified by iodixanol gradient centrifugation (Sigma-Aldrich) and an Amicon-Ultra Centrifugal Filter Unit (EMD Millipore) for buffer exchange and concentration. In vitro experiments. Human alveolar type II epithelial cells (A549) were grown in Dulbeccos Minimum Essential Media (Life Technologies), supplemented with 10% FCS and 1% penicillin-streptomycin. Twenty-four-well plates seeded with 80,000 cells per well were ...
I Respiratory System. A. Functional divisions 1. Conducting structures - carry air to and from the lungs. 2. Respiratory units - exchange gases between air and blood. B. Anatomy of Conducting Structures. 1. pharynx. a. openings. b. swallowing. 2. larynx a. cartilages. b. vocal folds. 3. trachea. a. C - shaped cartilages. 4. primary bronchi. a. carina. b. right bronchus vs. left bronchus. 5. secondary (lobar) bronchi 6. tertiary (segmental) bronchi 7. terminal bronchioles. a. structural transitions from bronchi to bronchioles. C. Anatomy of Respiratory Units 1. gross anatomy: lungs. a. surface anatomy. b. pleura and pleural cavity. 1. pneumothorax. c. lobes -, segments --, lobules --, respiratory units --, alveolus. 2. microscopic anatomy: alveolus. a. wall thinness. b. Type II cells: surfactant 1. infant respiratory distress syndrome. c. dust cells. D. Surface area to volume ratio. 1. 5 lobes vs. 500 million alveoli. 2. structural principle. E. Disorders. 1. asthma. 2. COPD. II Pulmonary ...
Download Aging, Immunity, and Infection (Infectious Disease) by Joseph F. Albright PDF - Nutritional Analysis Books
The receptors on type II pneumocytes and vascular endothelial cells responsible for attachment of pneumococci are of two types; both of them differ from the receptor on nasopharyngeal cells. Saccharides that can competitively inhibit the adherence of S. pneumoniae to pneumocytes and vascular endothelial cells help to define those receptors. They include mannose, GalNAc, Gal, the glycoconjugates asialo-GM1 and GM2, and the Gal NAcβ1-3 Gal-containing Forssman glycolipid (33). It should be mentioned here that the exposure of type II pneumocytes and vascular endothelial cells to the inflammatory cytokines TNFα and IL-1 significantly elevate the glycoconjugate receptors for pneumococci (33,42). L. , enterotoxigenic E. coli, Haemophilus influenzae, V. cholerae). Pathogens that penetrate epithelial barriers survive by invading and replicating in host cells. Tight junctions (zona occludens) that normally prevent penetration of epithelial cell layers also divide the epithelial cells into apical ...
Browsing Publications of the RG Phagosomen Biologie by Subject (MeSH)
Bacterial and parasitic intracellular pathogens or their secreted products have been shown to induce host cell transcriptional responses, which may benefit the host, favour the microorganism or be unrelated to the infection. In most instances, however, it is not known if the host cell nucleus is proximately required for the development of an intracellular infection. This information can be obtained by the infection of artificially enucleated host cells (cytoplasts). This model, although rather extensively used in studies of viral infection, has only been applied to few bacterial pathogens, which do not include Mycobacterium spp. Here, we investigate the internalization, phagosome biogenesis and survival of M. smegmatis in enucleated type II alveolar epithelial cells. Cytoplasts were infected with M. smegmatis, but the percentage of infection was significantly lower than that of nucleated cells. Scanning electron microscopy indicated that in both cells and cytoplasts, bacteria were internalized ...
Napsin A Detection: ELISAs and Antibodies
Novel Aspartic Proteinase of the PepSIN Family (Napsin A, or NAPSA) belongs to the peptidase A1 family and plays a role in pneumocyte surfactant processing. It is also known as aspartyl protease 4 (ASP4), KAP, Kdap, napsin-1, NAP1, NAPA, and SNAPA. Two closely related proteins are known, Napsin A and Napsin B. Napsin A is a single-chain, 38-kDa protein. It is expressed at high levels in human lung and kidney, and at lower levels in spleen. Napsin A expression has been detected in type II pneumocytes and in lung adenocarcinomas.. ...
Silent hypoxia: a frequently overlooked clinical entity in patients with COVID-19 | BMJ Case Reports
Throughout the recent weeks, there have been many discussions on silent hypoxia. Though it is not unique to COVID-19, adequate scientific data on this topic are lacking. This case demonstrates the importance of history taking and thorough clinical examination including the measurement of oxygen saturation to diagnose pulmonary involvement of COVID-19 at an early stage.. The mechanism of hypoxia in general can be explained in two ways-ventilation-perfusion mismatch and right to left shunt (intracardiac or intrapulmonary). Type 1 pneumocytes form the lining layer of alveoli and type 2 pneumocytes produce surfactant which regulates alveolar surface tension thereby maintaining the compliance of lung. SARS-CoV-2 spike protein mainly uses the ACE2 receptors as the attachment site to enter pneumocytes.5 The binding of SARS-CoV-2 spike protein to ACE2 receptors causes downregulation of the enzyme, resulting in ARDS due to the detrimental action of ACE (by mediating vasoconstriction, inflammation and ...
CiNii Articles - NAKATANI Yukio
Lung pathology of pale ear mouse (model of Hermansky-Pudlak syndrome 1) and beige mouse (model of Chediak-Higashi syndrome) : Severity of giant lamellar body degeneration of type II pneumocytes correlates with interstitial inflammation （2005 ...
Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium
Despite its known expression in both the vascular endothelium and the lung epithelium, until recently the physiological role of the adhesion receptor Gpr116/ADGRF5 has remained elusive. We generated a new mouse model of constitutive Gpr116 inactivation, with a large genetic deletion encompassing exon 4 to exon 21 of the Gpr116 gene. This model allowed us to confirm recent results defining Gpr116 as necessary regulator of surfactant homeostasis. The loss of Gpr116 provokes an early accumulation of surfactant in the lungs, followed by a massive infiltration of macrophages, and eventually progresses into an emphysemalike pathology. Further analysis of this knockout model revealed cerebral vascular leakage, beginning at around 1.5 months of age. Additionally, endothelial-specific deletion of Gpr116 resulted in a significant increase of the brain vascular leakage. Mice devoid of Gpr116 developed an anatomically normal and largely functional vascular network, surprisingly exhibited an attenuated ...
Tissue expression of LRRK2 - Summary - The Human Protein Atlas
Summary of LRRK2 (DKFZp434H2111, FLJ45829, PARK8, RIPK7, ROCO2) expression in human tissue. Cytoplasmic expression in several cell types, including pneumocytes and cells in renal tubules.
Altered proteomic patterns in rat alveolar epithelial type II cells after ventilation with high and low tidal volumes |...
A proteomics approach to ventilator-induced lung injury might identify protein patterns that contribute to epithelial injury. To identify changes in alveolar type II cells (ATII), rats were mechanically ventilated for 5 hours with a high tidal volume (HTV; 20 ml/kg, no positive end expiratory pressure) or a low tidal volume (LTV; 6 ml/kg, positive end expiratory pressure 4 cmH2O) and compared with pooled controls without mechanical ventilation (SV). ATII were isolated and lysed. Protein expression was compared using the recently introduced cleavable isotope coded affinity tag (ICAT) methodology. After tryptic digestion, cysteine containing peptides were tagged with biotin, extracted using an avidin-coated column and identified by HPLC and mass spectrometry with collision-induced dissociation. Spectra were interrogated against the Swissprot database and quantified using the ProteinProspector software. HTV ventilation resulted in morphologic changes, pulmonary edema and neutrophil influx in the ...
Correction of Genetic Mutation in Stem Cells Offers Directions for Treatment of Lung Diseases in Children | School of Medicine
For the first time, researchers have developed a way to coax pluripotent stem cells into a specific type of mature lung cell called alveolar epithelial type II cells (AEC2s) and to correct a mutant gene whose dysfunction in these cells is known to cause respiratory distress in infants.. The findings, which appear in Cell Stem Cell, will make it easier to study lung diseases like neonatal respiratory distress, COPD and interstitial lung diseases, caused by dysfunctional AEC2s, which until now were unable to survive and multiply long enough in cell culture to be studied or genetically corrected.. AEC2s are the key cells that act to maintain lung air sacs in both infants and adults. They are responsible for responding to lung injury and secreting a substance called pulmonary surfactant that helps keep the lungs open. It is believed that dysfunction of these specific cells leads to the development of many poorly understood alveolar lung diseases (diseases of the air sacs in the lungs) and is the ...
Development of a lung model utilizing human alveolar epithelial cells for evaluating aerosol drug delivery | RTI
Kazantseva, M., Cooney, D., & Hickey, A. (2002). Development of a lung model utilizing human alveolar epithelial cells for evaluating aerosol drug delivery. In Respiratory Drug Delivery VIII (pp. 707 - 710). Raleigh, NC: Davis Horwood International Publishing, Ltd ...
Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenua by Jos L. van der Velden, John F. Alcorn et al.
The stress-induced kinase, c-Jun-N-terminal kinase 1 (JNK1) has previously been implicated in the pathogenesis of lung fibrosis. However, the exact cell type(s) wherein JNK1 exerts its pro-fibrotic role(s) remained enigmatic. Herein we demonstrate prominent activation of JNK in bronchial epithelia using the mouse models of bleomycin- or AdTGFbeta1-induced fibrosis. Furthermore, in lung tissues of patients with idiopathic pulmonary fibrosis (IPF), active JNK was observed in various regions including type I and type II pneumocytes and fibroblasts. No JNK activity was observed in adjacent normal tissue or in normal control tissue. To address the role of epithelial JNK1, we ablated Jnk1 form bronchiolar and alveolar type II epithelial cells using CCSP-directed Cre recombinase-mediated ablation of LoxP-flanked Jnk1 alleles. Our results demonstrate that ablation of Jnk1 from airway epithelia resulted in a strong protection from bleomycin- or adenovirus expressing active transforming growth factor beta-1
Microscopic Study of the Lungs of Sprague-Dawley Rats from Various Ages of Postnatal and Aging Periods | Science Publications
Physiological changes in postnatal and aging lung are associated with a variety of microscopic changes in the lung, especially the alveolar lung tissue, both in the interstitial and epithelial component. Interstitial tissue of the lung will increase in thickness that is supposed to be due to changes in fiber composition, particularly collagen. However, the exact changes are still under debate and the underlying process is still unclear. The epithelial component that experiences changes is type II alveolar cells or pneumocyte II (surfactant producing cells). The ratio of pneumocyte II against pneumocyte I is expected to decline with age. This decrease will certainly affect their function in maintaining pulmonary surfactant supply. To maintain normal vital functions and synthesis of surfactant, lung tissue is also dependent on the availability of glucose because glucose is the fundamental building blocks of glycerol backbone of surfactant. In the aging process, accumulation of glycogen in the brain,
Pulmonary alveolar epithelial inducible NO synthase gene expression: Regulation by inflammatory mediators<...
TY - JOUR. T1 - Pulmonary alveolar epithelial inducible NO synthase gene expression. T2 - Regulation by inflammatory mediators. AU - Gutierrez, H. H.. AU - Pitt, B. R.. AU - Schwarz, M.. AU - Watkins, S. C.. AU - Lowenstein, C.. AU - Caniggia, I.. AU - Chumley, P.. AU - Freeman, B. A.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - Nitric oxide (·NO) is a short-lived mediator that can be induced by different cytokines and lipopolysaccharide (LPS) in a variety of cell types and produces many physiological and metabolic changes in target cells. In the current study, we show that a combination of cytokines, LPS, and zymosan- activated serum (ZAS; called for convenience cytomix Z) induces production of high concentrations of the NO oxidation products nitrite (NO2/-) and nitrate (NO3/-) by cultured rat fetal lung epithelial type II cells in a time-dependent fashion. Interferon-γ and tumor necrosis factor-α alone did not significantly affect ·NO synthesis, whereas ZAS, LPS, and interleukin- 1β caused only a ...
Several advancements have been made in delineating the role of NOX 2 and NOX 4 isoforms in ENaC regulation, and further work has explored novel redox-sensitive signal transduction pathways that regulate lung ENaC. In particular, it has been shown that NOX 2 and NOX 4 are expressed in alveolar epithelial type 1 and type 2 cells. Furthermore, gp91phox, the catalytic domain of Rac-1-dependent NOX enzymes, has been coimmunoprecipitated with the α-ENaC subunit (35, 90). The proximity of RS release with active Na+ channel subunit indicates that these unstable, reactive molecules can indeed regulate apically located channels embedded in the cell membrane before targeted dismutation of the RS. Further evidence indicating an important role of NOX-derived RS includes studies in which inhibition of the small G protein Rac-1, using NSC-23766 compound, inhibited both O2·− production and ENaC activity in the alveolar epithelium. In the same study, tracheally instilling NSC-23766 alongside saline ...
Covidien and Phillips launch next generation pulse oximetry product
Covidien (NYSE:COV ) and Philips  (NYSE:PHG ) are launching another pulse oximetry product as part of a long-running partnership. Mansfield, Mass.-based Covidien said it will provide its Nellcor SpO2 pulse oximetry technology for use with the Philips IntelliVue patient monitoring platform in North America, Europe and elsewhere. The partnership between 2 of the largest companies in the medical device space dates back to 2009, according to a Covidien spokeswoman. The company does not break out how much revenue it derives from the distribution deal, as the Respiratory & Monitoring Solutions division is 1 of 5 operating units in the companys medical device segment, which brought in over $2 billion in sales  during the 3 months ended March 30. Covidien recently bolstered the respiratory unit with a $300 million acquisition  of Oridion Systems in April. That deal is expected to close this quarter.. Because Nellcor OxiMax technology relies on cardiac signals, it mitigates signal ...
Overexpression of Sulf2 in idiopathic pulmonary fibrosis | Lung Tissue Research Consortium
Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis. In this study, we focused on the role of Sulf2 in modulating TGF-β1 function and the development of pulmonary fibrosis. We found that Sulf2 mRNA was overexpressed in lung samples from human patients with idiopathic pulmonary fibrosis (IPF), and Sulf2 protein was specifically localized to the hyperplastic type II alveolar epithelial cells (AECs). In vitro, TGF-β1 induced the expression of Sulf2 with accompanied HS 6-O-desulfation in A549 cells, adenocarcinoma cells derived from the type II alveolar epithelium. Using small interference RNA to block Sulf2 expression, we observed a biphasic TGF-β1 response with early enhanced Smad ...
Actin depolymerization is developmentally regulated in rat type II cells exposed to terbutaline.
The type II alveolar epithelial cell synthesizes and secretes pulmonary surfactant. Terbutaline enhances phospholipid release from adult and fetal type II cells. Our hypothesis is that the actin network of microfilaments regulates the secretory activ
Fondation Recherches 3R / Projets / 3R-Project 46-96
Primary human lung cells or cell lines were cultured on a stretchable silastic membrane forming the bottom of a 12-well plexiglas® box. The box was connected to an adult ventilator and ventilated for up to 36 hours at 20 cycles/min with a pressure-volume regimen resembling that of MV. Several lung cell types were tested in this model. The alveolar macrophage was identified as the main cellular source of key inflammatory mediators, such as tumor necrosis factor, the chemokine interleukin (IL)-8, and matrix metalloproteinase-9, produced during mechanical ventilation. Mechanical ventilation also induced low levels of IL-8 secretion by human alveolar epithelial type II-like cells. Other lung cell types such as endothelial cells, bronchial cells, and fibroblasts failed to produce IL-8 in response to mechanical ventilation (1,2). Conclusions and Relevance for 3R ...
Pneumotox » Pattern » XV.i - Path: Pneumocyte atypia (reactive epithelial cells) (a.k.a. the Napoleon Hat sign)
Exogenous surfactant application in a rat lung ischemia reperfusion injury model: effects on edema formation and alveolar type...
Prophylactic exogenous surfactant therapy is a promising way to attenuate the ischemia and reperfusion (I/R) injury associated with lung transplantation and thereby to decrease the clinical occurrence of acute lung injury and acute respiratory distress syndrome. However, there is little information on the mode by which exogenous surfactant attenuates I/R injury of the lung. We hypothesized that exogenous surfactant may act by limiting pulmonary edema formation and by enhancing alveolar type II cell and lamellar body preservation. Therefore, we investigated the effect of exogenous surfactant therapy on the formation of pulmonary edema in different lung compartments and on the ultrastructure of the surfactant producing alveolar epithelial type II cells. Rats were randomly assigned to a control, Celsior (CE) or Celsior + surfactant (CE+S) group (n = 5 each). In both Celsior groups, the lungs were flush-perfused with Celsior and subsequently exposed to 4 h of extracorporeal ischemia at 4°C and 50 min of
Prevention of Paraquat Toxicity in Suspensions of Alveolar Type II Cells by Paraquat-Specific Antibodies - UQ eSpace
1 The herbicide, paraquat, is accumulated by the energy-dependent polyamine uptake pathway of alveolar type I.I. cells. There it undergoes redox cycling that results in an amplified production of toxic reactive oxygen species and depletion of NADPH and other reducing equivalents. These processes account for the lung being the major target organ for paraquat toxicity. 2 We postulated that paraquat-specific antibodies would inhibit the uptake of the herbicide by type I.I. cells and prevent its toxicity. Accordingly, we examined the effects of paraquat-specific monoclonal antibodies and Fab fragments on the uptake, efflux and cytotoxicity of 50 μM paraquat in suspensions of alveolar type I.I. cells isolated from the rat. 3 The uptake of paraquat was linear over 40 min. Over this time, the uptake rate was inhibited significantly (% inhibition, 73-89) by IgG (25 or 50 μM) or Fab fragments (50 or 100 μM). 4 The apparent efflux rate of paraquat, studied over 16 h, was increased significantly from ...
Mechanisms of Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia
The expression of αvβ6 integrin is also induced in alveolar type II epithelial cells after acute lung injury (ALI) (Breuss et al., 1995), and in the respiratory epithelium of smokers
Doxycycline 2 months : Online and Mail-Order Pharmacies
8th CJD Family Conference. Saturday, July 17th 2010. Presentations: Conference Welcome, Florence Kranitz;. Doxycycline Clinical Trial Update, Fabrizio Tagliavini.2017, State University of New York College at Plattsburgh, Tjalfs review: Doxycycline 200 mg, 100 mg. Cheap Doxycycline online no RX..The clinical manifestations become apparent after an incubation period carrying from a few months to. Doxycycline therefore. filariasis treatments. 1.2.. Focal proliferative lesions of alveolar type II pneumocytes were observed as early as seven days after induction with doxycycline; after two months of induction,.The legally binding text is the original French version TRANSPARENCY COMMITTEE. doxycycline 2.2. three months prior to inclusion could not be included in.2) Techniques de jeu Bend, slide, hammer. 1) Le bend; 2) Le hammer-on; 3) Le pull off; 4) Le slide; 3) Le Blues turnaround, riffs. Les bases du Blues.FAQ • Pneumonia, Mycoplasma. ive had problems with this disease for over 2 months. ...
Regulation of alveolar epithelial cell phenotypes in fetal she...
Regulation of alveolar epithelial cell phenotypes in fetal sheep: roles of cortisol and lung expansion.: Our aim was to determine whether cortisols effect on a
What is Surfactant? The alveoli contain many types of cells. Among them Type 2 Pneumocytes produces surfactant. The main function of surfactant is to reduce surface tension, so that decrease the work of breathing. Surfactant forms a thin monomolecular layer at the air fluid interface. Surfactant layer is not static. It is continuously secreting and reabsorbing. Deficiency of surfactant causes Respiratory …. Read More » ...
Virtual Design Software for AECs | Mechdyne
Mechdynes 3D and virtual reality technology allows AECs to explore virtual designs to create functional and optimal ergonomics.
CiNii 論文 - Dexamethasone Increases β 2 : Adrenoceptor : Regulated Phosphatidylcholine...
Insufficient production of pulmonary surfactant in alveolar type II cells is relevant to many lung diseases. To cure its deficiency, glucocorticoid is commonly used in clinical areas. In the present study, we investigated the effect of dexamethasone on the secretion of phosphatidylcholine, a major phospholipid of pulmonary surfactant, in a primary culture of rat alveolar type II cells. Dexamethasone had no effect on the basal secretion rate of phosphatidylcholine. Dexamethasone augmented both the phosphatidylcholine secretion and the cyclic AMP formation increased by terbutaline. Furthermore, dexamethasone increased the number of β-adrenoceptors and mRNA expression of β,SUB,2,/SUB,-adrenoceptors in type II cells. These findings indicate that dexamethasone increases pulmonary surfactant secretion through an enhancement of β,SUB,2,/SUB,-adrenoceptor gene expression.. ...
While the adult murine lung utilizes multiple restricted progenitor cells during | Beneficial Effects of RAF Inhibitor i
While the adult murine lung utilizes multiple restricted progenitor cells during homeostasis and fix compartmentally, very much less is known about the progenitor cells from the human lung. fix utilizing murine versions have got provided essential ideas into both lung regeneration and homeostasis. These research have got proven that the adult mouse lung epithelium can be fairly quiescent and will not really adhere to the traditional control cell model . Rather, the lung shows up to conform to a maintenance structure identical to that of various other tissue with gradual turnover prices, such as the pancreas , . During regular tissues homeostasis, abundant facultative progenitor cells located throughout the lung epithelium mediate any 1420477-60-6 manufacture required maintenance. These facultative progenitor cells, Clara cells and Type II pneumocytes, are quiescent and function as differentiated cells of the mature lung epithelium, but keep the capability to differentiate and self-renew ...
Beneficial effects of inhaled NO on apoptotic pneumocytes in pulmonary thromboembolism model | Theoretical Biology and Medical...
Previously, we have successfully established a modified canine PTE model. This model has mimicked the pathological changes of chronic PTE. Due to a precise embolization into the intended right lower pulmonary artery, it is convenient for us to perform embolectomy for investigating the effects of the LIRI in the model. The three types of reddish brown thrombus enucleated by embolectomy from the involved pulmonary lobar artery revealed the irregular surface with multiple pink granulation-like protrusions and multiple branches corresponding to the lobar artery branches. Generally, during ischemia-reperfusion injury in systemic vascular beds, the vascular response appears to occur in at least two phases: (1) ischemia, which is associated with lack of oxygen, cell damage, and activation of cytotoxic enzymes, and (2) reperfusion, which is associated with formation of reactive oxygen intermediates, platelet and neutrophil activation, endothelial cell injury, increased vascular permeability, cytokine ...
Modern Homoeopathy | If The cause is unknown
The fibrosis in IPF has been linked to cigarette smoking, environmental factors (e.g. occupational exposure to gases, smoke, chemicals or dust.), and other medical complications including gastro intestinal reflex disease (GERD) or to genetic predisposition (Familial IPF).. IPF is the result of an aberrant wound healing process including, involving abnormal & excessive deposition of Collagen (Fibrosis) in the pulmonary interstitium with minimal associated inflamation.. It is seen that the initial or repetitive injury in IPF appears to lung cells, called alveolar epithelial cells (AECs Pneumocytes), which line the majority of alveolar surface.. When type I AECs are damaged or last, it is through basement membranes.. In normal repair, the hyperplastic type II AECs die & remaining cells spread & undergo a differentiation process to become type I AECs.. Under pathologic conditions & in the presence of transforming growth factor beta (TGFB), fibroblasts accumulate in these areas of damage & ...
Human Pulmonary Alveolar Epithelial Cell MicroRNA - Science PRO
Human Pulmonary Alveolar Epithelial Cell MicroRNA https://www.sciencepro.com.br/produtos/sc-3207 https://www.sciencepro.com.br/@@site-logo/logo-novo.png ...
Bodie granule - Krbové vložky oboustranné
Monitorujeme aktuální akční letáky Kauflan Lidl, Tesco, . Krmivo Rasco hovězí pro psy 10kg. NovaEqui vzniklo ve spolupráci tří českých fireBODIT TACHOV s. Kompletní krmivo pro dospělé psy. Mléčné granule pod názvem Axcelera-C (A-C) a doplňkové krmivo Novanel, které.. Porovnání cen bodie granule pro psy, srovnání cen bodie granule pro psy na portálu HLEDEJCENY. FROLIC s hovězím masem a zeleninou 500g. Poloměkké masové granule pro dospělé psy všech plemen . Dentální pochoutka jako odměna pro Vašeho psa s kuřecím masem.. In cell biology, lamellar bodies are secretory organelles found in type II alveolar cells in the. Bodit NOVAEQUI Classic 20kg. Involvement of corneodesmosome degradation and lamellar granule transportation in the desquamation process. Medical Molecular Morphology. Akční ceny výrobky a krmivo pro psy 25.. Granule pro psy Bono 17Kč, platí pouze do 20. ...
Elovanoids downregulate canonical SARS-CoV-2 cell-entry mediators and enhance protective signaling in human alveolar cells |...
The pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) in human primary alveoli cells in culture. We uncovered that very-long-chain polyunsaturated fatty acid precursors (VLC-PUFA,n-3) activate ELV biosynthesis ...
Development and maintenance of the alveolar type 1 cell - Tushar Desai
This new investigator proposal describes a 5 year training program for the development of a career as a Dhysician scientist in pulmonary medicine. The principal...
Hahon, N; Castranova, V (1989). "Interferon production in rat type II pneumocytes and alveolar macrophages". Exp Lung Res. 15 ( ...
Shintani, Y; Ohta, M; Iwasaki, T; Ikeda, N; Tomita, E; Nagano, T; Kawahara, K (2010). "A case of micronodular pneumocyte ... Kobashi, Y; Sugiu, T; Mouri, K; Irei, T; Nakata, M; Oka, M (2008). "Multifocal micronodular pneumocyte hyperplasia associated ... Miravet Sorribes, L; Mancheño Franch, N; Batalla Bautista, L (2013). "Multifocal micronodular pneumocyte hyperplasia in a ... Pulmonary atypical adenomatous hyperplasia Multifocal micronodular pneumocyte hyperplasia Behnes, C. L.; Schütze, G; Engelke, C ...
... and lyse in human macrophages and pneumocytes. A study in 2003 examined P. acanthamoebae's ability to enter and survive in ... "Parachlamydia Acanthamoebae Enters and Multiplies within Pneumocytes and Lung Fibroblast". Microbes and Infections. 8 (5): 1294 ...
Two types are pneumocytes or pneumonocytes known as type I and type II cells found in the alveolar wall, and a large phagocytic ... Type I pneumocytes are unable to replicate and are susceptible to toxic insults. In the event of damage, type II cells can ... Type I cells, also called type I pneumocytes, or type I alveolar cells, are squamous, thin and flat and form the structure of ... MUC1, a human gene associated with type II pneumocytes, has been identified as a marker in lung cancer. The alveolar ...
Adenocarcinoma of the lung
Type I pneumocytes cover 95% of alveolar surfaces, and are not able to regenerate. Type II pneumocytes are more common, making ... Adenocarcinoma of the lung develops in a step-wise progression as type II pneumocytes undergo consecutive molecular changes ... Alveoli are composed of two cell types, type I and type II pneumocytes. ...
... protein is linked with the maturation of dendritic cells, and as a marker for transformed type II pneumocytes or alveolar ... 2004). "Human dendritic cell lysosome-associated membrane protein expressed in lung type II pneumocytes". Arch. Biochem. ... "CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes". Am J ...
The two types of cell are known as type I and type II cells (also known as pneumocytes). Types I and II make up the walls and ... expressed in type II pneumocytes. Other proteins with elevated expression in the lung are the dynein protein DNAH5 in ciliated ... "In vitro generation of type-II pneumocytes can be initiated in human CD34+ stem cells". Biotechnology Letters. 38 (2): 237-242 ...
Air-liquid interface cell culture
More recently, a study on In vitro generation of type-II pneumocytes initiated from human CD34(+) stem cells has been ... "In vitro generation of type-II pneumocytes can be initiated in human CD34(+) stem cells". Biotechnology Letters. 38 (2): 237- ...
Epithelial cells, specifically type II pneumocytes, also internalize conidia which traffic to the lysosome where ingested ... Germination occurs both extracellularly or in type II pneumocyte endosomes containing conidia. Following germination, ...
Desquamative interstitial pneumonia
Its name is derived from the former belief that these macrophages were pneumocytes that had desquamated. It is associated with ...
NK2 homeobox 1
TTF-1 positive cells are found in the lung as type II pneumocytes and club cells. In the thyroid, follicular and parafollicular ...
Zaas DW, Duncan MJ, Li G, Wright JR, Abraham SN (February 2005). "Pseudomonas invasion of type I pneumocytes is dependent on ...
Acute interstitial pneumonitis
The septa are lined with atypical, hyperplastic type II pneumocytes, thus leading to the collapse of airspaces. Other ...
In addition, granzymes may also be expressed in non-immune cells such as keratinocytes, pneumocytes and chondrocytes. As many ...
Nitrogen dioxide poisoning
Mucous membrane is primarily affected alongside with type I pneumocyte and the respiratory epithelium. The generation of free ...
Atypical adenomatous hyperplasia
Kobashi, Y; Sugiu, T; Mouri, K; Irei, T; Nakata, M; Oka, M (2008). "Multifocal micronodular pneumocyte hyperplasia associated ... The needle biopsy rate is less than 1%. Multifocal micronodular pneumocyte hyperplasia (MMPH) in situ pulmonary adenocarcinoma ... "Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis: Differentiation from multiple atypical ...
Acute inhalation injury
Type 2 pneumocytes are more resistant to damage, which is important as these cells produce surfactant, transport ions and ... There are two types of alveolar epithelial cells - Type 1 pneumocytes represent 90% of the cell surface area, and are easily ... Prolonged inflammation and destruction of pneumocytes leads to fibroblastic proliferation, hyaline membrane formation, tracheal ...
This is significant because cortisol induces type II pneumocytes of the lungs to synthesize and secrete pulmonary surfactant; ...
This affects in the cells action potential profile, as seen in cardiomyocytes, pneumocytes and neurons leading to conduction ...
... of the phospholipids contained in pulmonary surfactant takes place in the endoplasmic reticulum of type II pneumocytes. ...
... cases of COVID-19 are associated with extensive lung damage and the presence of infected multinucleated syncytial pneumocytes. ...
"Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes". Am. J ...
It can be both broken down by macrophages and/or reabsorbed into the lamellar structures of type II pneumocytes. Up to 90% of ... surfactant DPPC (dipalmitoylphosphatidylcholine) is recycled from the alveolar space back into the type II pneumocyte. This ...
... on type II pneumocytes". American Journal of Physiology. Lung Cellular and Molecular Physiology. 291 (3): L436-46. doi:10.1152/ ...
Idiopathic pulmonary fibrosis
... pneumocytes), which line the majority of the alveolar surface. When type I AECs are damaged or lost, it is thought that type II ... morphology and ultrastructural evidence for a type II pneumocyte defect". Chest. 125 (6): 2278-2288. doi:10.1378/chest.125.6. ...
Equine multinodular pulmonary fibrosis
In addition hypertrophy of type II pneumocytes, formation on abnormal cystic airspaces and viral eosinophilic intranuclear ...
It appears to act as a tumor suppressor, and is expressed strongly in the skin, distal nephrons, and type I pneumocytes. It has ...
The alveolar macrophage is the third cell type in the alveolus, the others are the type I and type II pneumocytes. Alveolar ... The lungs are especially sensitive and prone to damage, thus to avoid collateral damage to type 1 and type II pneumocytes, ... near the pneumocytes, but separated from the wall. Activity of the alveolar macrophage is relatively high, because they are ...
International Classification of Diseases for Oncology
... type II pneumocyte and goblet cell type Bronchiolo-alveolar carcinoma, indeterminate type M8255/3 Adenocarcinoma combined with ... type II pneumocyte M8253/3 Bronchiolo-alveolar carcinoma, mucinous (C32._) Bronchiolo-alveolar carcinoma, goblet cell type ...
Adenocarcinoma in situ of the lung
In non-mucinous BAC, neither club cell nor type II pneumocyte differentiation appears to affect survival or prognosis. When BAC ... and often shows features of club cell or Type II pneumocyte differentiation. Mucinous AIS, in contrast, probably derives from a ...
Multifocal micronodular pneumocyte hyperplasia - Wikipedia
Multifocal micronodular pneumocyte hyperplasia (MMPH) is a subtype of pneumocytic hyperplasia (hyperplasia of pneumocytes ... Type II pneumocytes without nuclear atypia lined thickened alveolar septa and proliferated papillary structures. Enlarged ... Shintani, Y; Ohta, M; Iwasaki, T; Ikeda, N; Tomita, E; Nagano, T; Kawahara, K (2010). "A case of micronodular pneumocyte ... Kobashi, Y; Sugiu, T; Mouri, K; Irei, T; Nakata, M; Oka, M (2008). "Multifocal micronodular pneumocyte hyperplasia associated ...
NIOSHTIC-2 Publications Search - 00189546 - Interferon production in rat type II pneumocytes and alveolar macrophages.
Type-II pneumocytes and alveolar macrophages isolated from the lungs of male Sprague-Dawley-rats were inoculated with Ao/PR/8/ ... Interferon production in rat type-II pneumocytes and alveolar macrophages in response to viral stimulation was examined. ... Type-II pneumocytes and alveolar macrophages isolated from the lungs of male Sprague-Dawley-rats were inoculated with Ao/PR/8/ ... The authors conclude that rat type-II pneumocytes are active producers of interferon in response to a viral inducer. Type-II ...
Pegylated interferon-α protects type 1 pneumocytes against SARS coronavirus infection in macaques | Nature Medicine
We therefore suggest that pegylated IFN-α protects type 1 pneumocytes from SCV infection, and should be considered a candidate ... Here we show extensive SCV antigen expression in type 1 pneumocytes of experimentally infected cynomolgus macaques (Macaca ... viral antigen expression by type 1 pneumocytes and pulmonary damage, compared with untreated macaques. Postexposure treatment ... Pegylated interferon-α protects type 1 pneumocytes against SARS coronavirus infection in macaques. *Bart L Haagmans1. na1, ...
Fusion-activated Ca2+ entry via vesicular P2X4 receptors promotes fusion pore opening and exocytotic content release in...
1999) Threshold calcium levels for lamellar body exocytosis in type II pneumocytes. Am J Physiol 277:L893-L900. ... during the postfusion stage of lamellar body exocytosis in rat type II pneumocytes. PLoS ONE 5:e10982. ... Ca2+ entry via vesicular P2X4 receptors promotes fusion pore opening and exocytotic content release in pneumocytes. Pika ... Ca2+ entry via vesicular P2X4 receptors promotes fusion pore opening and exocytotic content release in pneumocytes ...
Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium
Proliferation of alveolar type II pneumocytes is stimulated by Jagged-1 in vitro | European Respiratory Society
Proliferation of alveolar type II pneumocytes is stimulated by Jagged-1 in vitro. Rainer Zembacher, Susanna Desole, Caroline ... Proliferation of alveolar type II pneumocytes is stimulated by Jagged-1 in vitro ... Proliferation of alveolar type II pneumocytes is stimulated by Jagged-1 in vitro ... Proliferation of alveolar type II pneumocytes is stimulated by Jagged-1 in vitro ...
micronodular pneumocyte hyperplasia - Humpath.com - Human pathology
First recognized in 1991 by HH Popper (Histopathology 1991;18:347). Also called, multifocal micronodular pneumocyte hyperplasia ... Home , E. Pathology by systems , Respiratory system , Lungs , micronodular pneumocyte hyperplasia. micronodular pneumocyte ... Definition : MPH is a benign, hamartomatous, multinodular proliferation of type II pneumocytes. It is often associated with ... First recognized in 1991 by HH Popper (Histopathology 1991;18:347). Also called, multifocal micronodular pneumocyte hyperplasia ...
Membranous pneumocyte | definition of membranous pneumocyte by Medical dictionary
What is membranous pneumocyte? Meaning of membranous pneumocyte medical term. What does membranous pneumocyte mean? ... Looking for online definition of membranous pneumocyte in the Medical Dictionary? membranous pneumocyte explanation free. ... redirected from membranous pneumocyte). Also found in: Dictionary, Thesaurus. mem·bra·nous. (membră-nŭs), Relating to or of ... Membranous pneumocyte , definition of membranous pneumocyte by Medical dictionary https://medical-dictionary.thefreedictionary. ...
Massive bilateral renal angiomyolipomatosis and multifocal micronodular pneumocytes hyperplasia associated with tuberous...
Simkania negevensis may produce long lasting infections in human pneumocytes and endometrial cells. | Physician's Weekly for...
Simkania negevensis may produce long lasting infections in human pneumocytes and endometrial cells. by Logan Thomison , Jan 16 ... pneumocytes and endometrial cells) and further evaluated the characteristics of its replicative vacuole. We demonstrated that S ... with the shortest doubling time and an increased adhesion observed in pneumocytes. Our work highlights the specificities of the ...
Massive bacterial cell invasion and reactive type II pneumocytes in bronchoalveolar lavage fluid from a preterm neonate | ADC...
Wood smoke particles from different combustion phases induce similar pro-inflammatory effects in a co-culture of monocyte and...
Pneumotox » Drug » Cyclophosphamide » XV.i - Path: Pneumocyte atypia (reactive epithelial cells)
cytomegalovirus: cytomegalovirus infection of a lung pneumocyte ...
Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte...
Cultured pneumocytes express the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor angiotensin-converting ... Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte ... and modular alveolosphere culture system for the propagation and differentiation of human alveolar type 2 cells/pneumocytes ...
Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)/usual interstitial...
Because type I pneumocytes are produced by the proliferation and transformation of type II pneumocytes, the progressive ... ELECTRON MICROSCOPY OF APOPTOTIC TYPE II PNEUMOCYTES. Figure 3A-C shows an electron microscopical view of type II pneumocytes. ... Another consequence of type II pneumocyte apoptosis might be related to the turnover of type I pneumocytes. ... 14 Type II pneumocytes, but not type I cells, are capable of undergoing mitosis and transformation into type I pneumocytes.15 ...
Pneumotox » Pattern » XV.i - Path: Pneumocyte atypia (reactive epithelial cells) (a.k.a. the "Napoleon Hat" sign)
XV.i - Path: Pneumocyte atypia (reactive epithelial cells) (a.k.a. the "Napoleon Hat" sign) XV.j XV - Pathology XV.j - Path: ... XV.i - Path: Pneumocyte atypia (reactive epithelial cells) (a.k.a. the "Napoleon Hat" sign) XV.j XV - Pathology XV.j - Path: ... XV.i - Path: Pneumocyte atypia (reactive epithelial cells) (a.k.a. the "Napoleon Hat" sign) XV.n XV - Pathology XV.n - Path: ... XV.i - Path: Pneumocyte atypia (reactive epithelial cells) (a.k.a. the "Napoleon Hat" sign) XV.ap XV - Pathology XV.ap - Path: ...
Piezo1 induced apoptosis of type II pneumocytes during ARDS | Respiratory Research | Full Text
The present study found the expression of Piezo1 in type II pneumocytes and investigated its role in mediating ARDS-related ... The increased intracellular Ca2+ induced the apoptosis of type II pneumocytes, which may be related to the Bcl-2 pathway. ... Piezo1 was expressed in type II pneumocytes as shown by immunofluorescence staining and expression was increased in the ARDS ... Piezo1 was expressed in type II pneumocytes. Mechanical stretch of alveoli during ARDS induced activation of the Piezo1 channel ...
Existence of exocytotic hemifusion intermediates with a lifetime of up to seconds in type II pneumocytes - University of...
Invasion of human type II pneumocytes by Burkholderia cepacia.
Both strains of B. cepacia were capable of invasion of type II pneumocytes in primary culture. Strain C1359 was capable of ... E. and Kerr, K.G. (2001). Invasion of human type II pneumocytes by Burkholderia cepacia. Microbial Pathogenesis. Vol. 30, No. 3 ... was found to survive in the pneumocytes for at least 24 h. Future studies on the invasiveness of B. cepacia can employ A549 ... within type II pneumocytes in primary culture using a gentamicin¿ceftazidime antibiotic protection assay. ...
Isolation and partial characterization of a receptor to surfactant protein a expressed by rat type II pneumocytes<...
Isolation and partial characterization of a receptor to surfactant protein a expressed by rat type II pneumocytes. In: American ... Isolation and partial characterization of a receptor to surfactant protein a expressed by rat type II pneumocytes. / Kresch, ... title = "Isolation and partial characterization of a receptor to surfactant protein a expressed by rat type II pneumocytes", ... T1 - Isolation and partial characterization of a receptor to surfactant protein a expressed by rat type II pneumocytes ...
Significance of alveolar macrophages, pneumocyte type II and Clara cells in lung toxicology - Fingerprint - Hungarian...
Rapid isolation of type II pneumocytes with magnetic removal of macrophages
Amiloride-inhibitable Na|sup|+|/sup| conductive pathways in alveolar type II pneumocytes
Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis - Libre Pathology
Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis, also multifocal micronodular pneumocyte ... Micronodule of pneumocyte hyperplasia in multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis. H&E ... 1.0 1.1 Nagar, AM.; Teh, HS.; Khoo, RN.; Morani, AC.; Vrishni, K.; Raghuram, J. (Feb 2008). "Multifocal pneumocyte hyperplasia ... Apr 1991). "Micronodular hyperplasia of type II pneumocytes--a new lung lesion associated with tuberous sclerosis.". ...
Pulmonary changes in cardiopulmonary bypass: short-term effects on granular pneumocytes.<...
Pulmonary changes in cardiopulmonary bypass: short-term effects on granular pneumocytes. CHEST. 1972 Feb;61(2):154-158. https ... Pulmonary changes in cardiopulmonary bypass: short-term effects on granular pneumocytes.. R. E. Sobonya, J. Kleinerman, F. ... Pulmonary changes in cardiopulmonary bypass : short-term effects on granular pneumocytes. / Sobonya, R. E.; Kleinerman, J.; ... title = "Pulmonary changes in cardiopulmonary bypass: short-term effects on granular pneumocytes.", ...
Nicotine upregulates ACE2 expression and increases competence for SARS-CoV-2 in human pneumocytes - PubMed
Increased Granzyme A Expression In Type II Pneumocytes of Patients With Severe COPD<...
Increased Granzyme A Expression In Type II Pneumocytes of Patients With Severe COPD. J.H. Vernooy*, G.M. Moller, R.J. van ... Increased Granzyme A Expression In Type II Pneumocytes of Patients With Severe COPD. / Vernooy, J.H.; Moller, G.M.; van Suylen ... GrA expression is increased in type II pneumocytes of patients with very severe COPD. These results indicate that GrA may be ... GrA expression is increased in type II pneumocytes of patients with very severe COPD. These results indicate that GrA may be ...
Multifocal micronodular pneumocyteProduced by type II pneumocytesMacrophagesSurfactantHyperplasia of type II pneumocytesPulmonaryEpithelial cellsApoptosisDifferentiationSevere acute respiApoptotic typeGranular pneumocytesProliferation of typeTuberousAntigen expressionAlveoliAtypiaMultinodularClaraCoronavirusViralInfectionNucleiAdenomaType IISARSCellsCellProminentMembranousExpression
Multifocal micronodular pneumocyte2
- Multifocal micronodular pneumocyte hyperplasia (MMPH) is a subtype of pneumocytic hyperplasia (hyperplasia of pneumocytes lining pulmonary alveoli). (wikipedia.org)
- Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis , also multifocal micronodular pneumocyte hyperplasia in tuberous sclerosis , is the presence of a rare relatively distinctive hamartomatous lesion of the lung in multiple foci in a person with tuberous sclerosis . (librepathology.org)
Produced by type II pneumocytes2
- Interferon production in rat type II pneumocytes and alveolar macrophages. (cdc.gov)
- Interferon production in rat type-II pneumocytes and alveolar macrophages in response to viral stimulation was examined. (cdc.gov)
- Type-II pneumocytes and alveolar macrophages isolated from the lungs of male Sprague-Dawley-rats were inoculated with Ao/PR/8/34 influenza and parainfluenza viruses at virus to cell ratios of 1.0 to 10. (cdc.gov)
- Maximum cytokine induction by type-II pneumocytes was three to four times higher than that of alveolar macrophages. (cdc.gov)
- MEASUREMENTS AND MAIN RESULTS: GrA and GrB immunoreactivity was observed in CD8+ CTLs and CD57+ NK cells, but also in type II pneumocytes and alveolar macrophages in both groups. (maastrichtuniversity.nl)
- SARS-CoV-2 was detectable by immunohistochemistry and electron microscopy in conducting airways, pneumocytes, alveolar macrophages, and a hilar lymph node but was not identified in other extrapulmonary tissues. (medscape.com)
- Synthesis of the phospholipid component of surfactant, phosphatidylcholine (PC), is stimulated by fibroblast-pneumocyte factor (FPF), a protein expressed by fibroblast cells within the fetal lung. (edu.au)
- The effect of IGF-II on synthesis of surfactant PC and its subsequent secretion from type II pneumocytes was studied. (edu.au)
- Type II pneumocytes were detected using a Pro-surfactant protein C antibody that is specific for alveolar Type II cells. (ashpublications.org)
- In addition, cells were capable of type 2 pneumocyte differentiation, as assessed by marker expression of surfactant protein C (pro-SPC) at the protein and the RNA level, and by the presence of lamellar bodies by transmission electron microscopy. (nih.gov)
- Their place may be taken by type 2 cells, the secretory pneumocytes, which are more cuboidal and active as producers of surfactant. (thefreedictionary.com)
- pneumocytes type 2 (for the production of surfactant). (doccheck.com)
Hyperplasia of type II pneumocytes2
- Here we show extensive SCV antigen expression in type 1 pneumocytes of experimentally infected cynomolgus macaques ( Macaca fascicularis ) at 4 d postinfection (d.p.i.), indicating that this cell type is the primary target for SCV infection early in the disease, and explaining the subsequent pulmonary damage. (nature.com)
- We also show that prophylactic treatment of SCV-infected macaques with the antiviral agent pegylated interferon-α (IFN-α) significantly reduces viral replication and excretion, viral antigen expression by type 1 pneumocytes and pulmonary damage, compared with untreated macaques. (nature.com)
- Pulmonary changes in cardiopulmonary bypass: short-term effects on granular pneumocytes. (elsevier.com)
- To investigate the effects of curcumin (CUR) on pneumocyte apoptosis and CCAAT/enhancer binding protein homologous protein (CHOP) in pulmonary ischemia / reperfusion injury (PIRI) in mice . (bvsalud.org)
- Based on the most prominent hypothesis of the mechanism of pulmonary fibrosis development, intracellular disruption of type II pneumocytes by ceroid may trigger an inflammation cascade, cytokine production and fibroblast proliferation, leading to progressive fibrosis [ 2 ]. (ersjournals.com)
- JSRV is the only retrovirus that transforms the differentiated epithelial cells of the lungs: type II pneumocytes ( 37 , 56 ) and Clara cells ( 50 ). (asm.org)
- This study was designed to investigate whether the apoptosis of type II pneumocytes could be the precipitating factor in the pathogenesis of IPF. (bmj.com)
- The increased intracellular Ca2+ induced the apoptosis of type II pneumocytes, which may be related to the Bcl-2 pathway. (biomedcentral.com)
- At present, little is known about the relation between LIRI and the induction of apoptosis on pneumocytes in acute or chronic PTE. (biomedcentral.com)
- Here, we report a feeder-free, scalable, chemically defined, and modular alveolosphere culture system for the propagation and differentiation of human alveolar type 2 cells/pneumocytes derived from primary lung tissue. (physiciansweekly.com)
- There is proliferation of type II pneumocytes to cover the damaged epithelial surface, followed by differentiation into type I pneumocytes. (scielo.br)
Severe acute respi1
- Cultured pneumocytes express the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor angiotensin-converting enzyme receptor type-2 (ACE2) and can be infected with virus. (physiciansweekly.com)
- These results indicate that apoptotic type II pneumocyte death occurs in normal alveoli of IPF/UIP and could be the principal cause of several events that account for the histological, clinical, and functional alterations seen in IPF/UIP. (bmj.com)
- The amounts of apoptotic type II pneumocytes in the lower lobar lung have negative correlation trend with the arterial blood PaO2/FiO2 in Reperfusion group and Inhaled NO group. (biomedcentral.com)
- Inhaled NO may be useful in treating LIRI in acute or chronic PTE by alleviating apoptotic type II pneumocytes. (biomedcentral.com)
- T2 - short-term effects on granular pneumocytes. (elsevier.com)
- With granular pneumocytes, uptake was linear with time but nonlinear with external concentration. (elsevier.com)
- Apparently, PQ can enter both cell types by diffusion, but granular pneumocytes can also accumulate PQ by an energy-dependent process. (elsevier.com)
- K(m-PQ) ~ 2 x 10 -4 M). The results suggest that PQ-dependent NADPH oxidation rates could differ markedly between cell types at low PQ concentration because of energy-dependent transport into granular pneumocytes but would be fairly close at high PQ concentration where diffusion predominates. (elsevier.com)
Proliferation of type1
- MPH is a benign, hamartomatous, multinodular proliferation of type II pneumocytes . (humpath.com)
- Multifocal pneumocyte hyperplasia in tuberous sclerosis. (librepathology.org)
- E-F) Immunofluorescence for virus antigen expression in pneumocytes. (news-medical.net)
- Conclusions -In conclusion, numerous type II pneumocytes from the normal alveoli of most patients with IPF/UIP actively undergo programmed cell death. (bmj.com)
- Type II pneumocytes without nuclear atypia lined thickened alveolar septa and proliferated papillary structures. (wikipedia.org)
- Several synonymous terms have been done for this entity: adenomatoid proliferation of alveolar epithelium, papillary alveolar hamartoma, multifocal alveolar hyperplasia, multinodular pneumocyte hyperplasia. (wikipedia.org)
- We excluded that OPA originates from a bronchioalveolar stem cell, or from mature post-mitotic type 2 pneumocytes or from either proliferating or non-proliferating Clara cells. (unizar.es)
- (C, D) There were no cells that were positive by immunostaining for the Clara cell marker CCSP (C) , while there were sparse cells that were cytokeratin-5 positive (D) . (E, F) As an additional method to positively identify the hBM-MSC-derived cells as type 2 pneumocytes, transmission electron microscopy (TEM) analysis was performed. (nih.gov)
- By transient-transfection assays of 23 different cell lines with a reporter plasmid driven by the JSRV long terminal repeat (LTR), pJS21-luc, we found that the JSRV LTR is preferentially active in cell lines derived from type II pneumocytes and Clara cells (MLE-15 and mtCC1-2 mouse cell lines). (asm.org)
- Coronavirus predominantly infects type II pneumocytes in the human lung. (clinicaltrials.gov)
- The authors conclude that rat type-II pneumocytes are active producers of interferon in response to a viral inducer. (cdc.gov)
- Expression of SARS virus-encoded RNA was detected in all 3 cases by RT-PCR, and the SARS viral signal was localized in pneumocytes by using in situ hybridization. (elsevier.com)
- The absence of detectable viral mented in other mammals and birds, H5N1 viral replication antigen-positive cells in previous reports may relate to the in humans may be restricted to the lung and intestine, and fact that the patients died during the late phase of the dis- the major site of H5N1 viral replication in the lung is the pneumocyte. (cdc.gov)
- Notably, the H5N1 virus targeted type II pneumocytes throughout the 7-day infection, and induced the most dramatic and sustained expression of type I interferons and inflammatory and innate immune genes, as measured by genomic and protein assays. (pnas.org)
- In this study, we demonstrated that lung adenocarcinoma in sheep originates from infection and transformation of proliferating type 2 pneumocytes (termed here lung alveolar proliferating cells, LAPCs). (unizar.es)
- Some type II pneumocytes have enlarged nuclei (arrow). (nih.gov)
- Electron microscopy demonstrated apoptotic changes in type II pneumocytes. (bmj.com)
- The present study found the expression of Piezo1 in type II pneumocytes and investigated its role in mediating ARDS-related lung injury. (biomedcentral.com)
- Piezo1 was expressed in type II pneumocytes as shown by immunofluorescence staining and expression was increased in the ARDS model. (biomedcentral.com)
- Piezo1 was expressed in type II pneumocytes. (biomedcentral.com)
- Invasion of human type II pneumocytes by Burkholderia cepacia. (brad.ac.uk)
- Two strains of B. cepacia of environmental (NCTC 10661) and clinical origin (C1359) were examined for their ability to invade and survive (over a 24 h period) within type II pneumocytes in primary culture using a gentamicin¿ceftazidime antibiotic protection assay. (brad.ac.uk)
- Both strains of B. cepacia were capable of invasion of type II pneumocytes in primary culture. (brad.ac.uk)
- These observations were confirmed by RT-PCR on total lung, LCM-enriched specific cell types and freshly isolated primary type II pneumocytes. (maastrichtuniversity.nl)
- The scores of GrA-expressing type II pneumocytes were significantly higher in COPD versus controls. (maastrichtuniversity.nl)
- Peripheral papillary adenomas of the lung are uncommon neoplasms (only ten cases have been described so far in the English literature) composed predominantly of type-II pneumocytes and generally considered benign. (semanticscholar.org)
- We further show dipeptidyl peptidase 4 expression, MERS-CoV replication, and RNA and protein synthesis in human airway epithelial cell cultures, primary lung fibroblasts, primary lung microvascular endothelial cells, and primary alveolar type II pneumocytes, demonstrating a much broader tissue tropism than severe acute respiratory syndrome coronavirus. (pnas.org)
- Primary cultures of lung fibroblasts and type II pneumocytes are prepared, and fibroblast-conditioned medium (FCM) is exposed to the type II cells. (edu.au)
- Drug Selection Enrichment of Type II Pneumocytes Following Transplant of P140K MGMT Lentiviral Transduced Hematopoietic Stem Cells. (ashpublications.org)
- In this study, we investigated whether hematopoietic donor-derived Type II pneumocytes could be enriched by lentiviral or retroviral expression of P140K MGMT. (ashpublications.org)
- Using this method, 10-12% of total cells isolated from the lung were Type II pneumocytes and 1.5-8% of these cells co-expressed AGT in mice treated with BG and BCNU (n=3). (ashpublications.org)
- This indicated drug selection mediated expansion of transplanted marrow-derived cells with characteristics of lung epithelial Type II pneumocytes. (ashpublications.org)
- c ) Type II pneumocytes positive for CXCL5. (nih.gov)
- Alveolar septum showing prominent type II pneumocyte proliferation. (cdc.gov)
- In type II pneumocytes, TMPRSS2 expression is associated with an increase in androgen receptor (AR) expression, specifically connecting AR expression to SARS-CoV-2, due to AR-regulated TMPRSS2 gene promoter. (clinicaltrials.gov)
- Emphysematous bullae and foamy swelling of the type II pneumocytes were also observed ( fig. 1d ). (ersjournals.com)
- Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction. (physiciansweekly.com)
- Simkania negevensis may produce long lasting infections in human pneumocytes and endometrial cells. (physiciansweekly.com)
- Here, we evaluated the ability of S. negevensis to replicate in potential environmental reservoirs, namely amoebae and arthropods, as well as in mammalian cells (Vero cells, pneumocytes and endometrial cells) and further evaluated the characteristics of its replicative vacuole. (physiciansweekly.com)
- (B) Immunostaining for pro-SPC shows numerous cells that are positive for the type 2 pneumocyte marker. (nih.gov)
- We demonstrated that S. negevensis efficiently replicates in all cell lines tested, with the shortest doubling time and an increased adhesion observed in pneumocytes. (physiciansweekly.com)
- d) Prominent vacuolated pneumocytes line an alveolus. (ersjournals.com)
- a ) CXCL1 expression on type 2 pneumocytes. (nih.gov)