Substances that are recognized by the immune system and induce an immune reaction.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Substances elaborated by bacteria that have antigenic activity.
A bifunctional enzyme that catalyzes the synthesis and HYDROLYSIS of CYCLIC ADP-RIBOSE (cADPR) from NAD+ to ADP-RIBOSE. It is a cell surface molecule which is predominantly expressed on LYMPHOID CELLS and MYELOID CELLS.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
Differentiation antigens expressed on B-lymphocytes and B-cell precursors. They are involved in regulation of B-cell proliferation.
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.
Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.
Substances elaborated by viruses that have antigenic activity.
Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. Activation of this receptor results in increased T-cell proliferation, cytokine production and promotion of T-cell survival.
Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Differentiation antigens expressed on pluripotential hematopoietic cells, most human thymocytes, and a major subset of peripheral blood T-lymphocytes. They have been implicated in integrin-mediated cellular adhesion and as signalling receptors on T-cells.
Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein.
Glycoprotein members of the immunoglobulin superfamily which participate in T-cell adhesion and activation. They are expressed on most peripheral T-lymphocytes, natural killer cells, and thymocytes, and function as co-receptors or accessory molecules in the T-cell receptor complex.
Ratio of T-LYMPHOCYTES that express the CD4 ANTIGEN to those that express the CD8 ANTIGEN. This value is commonly assessed in the diagnosis and staging of diseases affecting the IMMUNE SYSTEM including HIV INFECTIONS.
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Glycoproteins expressed on cortical thymocytes and on some dendritic cells and B-cells. Their structure is similar to that of MHC Class I and their function has been postulated as similar also. CD1 antigens are highly specific markers for human LANGERHANS CELLS.
Antibodies produced by a single clone of cells.
The 140 kDa isoform of NCAM (neural cell adhesion molecule) containing a transmembrane domain and short cytoplasmic tail. It is expressed by all lymphocytes mediating non-MHC restricted cytotoxicity and is present on some neural tissues and tumors.
Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function.
A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of their reactivity in normal and malignant myelomonocytic cells is useful in identifying and classifying human leukemias and lymphomas.
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Tetraspanin proteins found at high levels in cells of the lymphoid-myeloid lineage. CD53 antigens may be involved regulating the differentiation of T-LYMPHOCYTES and the activation of B-LYMPHOCYTES.
A cell adhesion protein that was originally identified as a heat stable antigen in mice. It is involved in METASTASIS and is highly expressed in many NEOPLASMS.
Zinc-binding metalloproteases that are members of the type II integral membrane metalloproteases. They are expressed by GRANULOCYTES; MONOCYTES; and their precursors as well as by various non-hematopoietic cells. They release an N-terminal amino acid from a peptide, amide or arylamide.
Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumors of B-cell origin.
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
Substances of fungal origin that have antigenic activity.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The major group of transplantation antigens in the mouse.
A 67-kDa sialic acid binding lectin that is specific for MYELOID CELLS and MONOCYTE-MACROPHAGE PRECURSOR CELLS. This protein is the smallest siglec subtype and contains a single immunoglobulin C2-set domain. It may play a role in intracellular signaling via its interaction with SHP-1 PROTEIN-TYROSINE PHOSPHATASE and SHP-2 PROTEIN-TYROSINE PHOSPHATASE.
Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Glycoproteins found on the membrane or surface of cells.
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
Sites on an antigen that interact with specific antibodies.
A subtype of tetraspanin proteins that play a role in cell adhesion, cell motility, and tumor metastasis. CD9 antigens take part in the process of platelet activation and aggregation, the formation of paranodal junctions in neuronal tissue, and the fusion of sperm with egg.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.
A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.
Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
Established cell cultures that have the potential to propagate indefinitely.
A sialic acid-rich protein and an integral cell membrane mucin. It plays an important role in activation of T-LYMPHOCYTES.
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Oligosaccharide antigenic determinants found principally on NK cells and T-cells. Their role in the immune response is poorly understood.
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS where it plays a role in stimulating the proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES.
A ubiquitously expressed complement receptor that binds COMPLEMENT C3B and COMPLEMENT C4B and serves as a cofactor for their inactivation. CD46 also interacts with a wide variety of pathogens and mediates immune response.
A class of animal lectins that bind to carbohydrate in a calcium-dependent manner. They share a common carbohydrate-binding domain that is structurally distinct from other classes of lectins.
Glycoproteins with a wide distribution on hematopoietic and non-hematopoietic cells and strongly expressed on macrophages. CD58 mediates cell adhesion by binding to CD2; (ANTIGENS, CD2); and this enhances antigen-specific T-cell activation.
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
A ubiquitously expressed membrane glycoprotein. It interacts with a variety of INTEGRINS and mediates responses to EXTRACELLULAR MATRIX PROTEINS.
A CD antigen that contains a conserved I domain which is involved in ligand binding. When combined with CD18 the two subunits form MACROPHAGE-1 ANTIGEN.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
An integrin alpha subunit of approximately 150-kDa molecular weight. It is expressed at high levels on monocytes and combines with CD18 ANTIGEN to form the cell surface receptor INTEGRIN ALPHAXBETA2. The subunit contains a conserved I-domain which is characteristic of several of alpha integrins.
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Progenitor cells from which all blood cells derive.
The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
GPI-linked membrane proteins broadly distributed among hematopoietic and non-hematopoietic cells. CD55 prevents the assembly of C3 CONVERTASE or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.
Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Tetraspanin proteins that are involved in a variety of cellular functions including BASEMENT MEMBRANE assembly, and in the formation of a molecular complexes on the surface of LYMPHOCYTES.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A member of the tumor necrosis factor receptor superfamily that is specific for 4-1BB LIGAND. It is found in a variety of immune cell types including activated T-LYMPHOCYTES; NATURAL KILLER CELLS; and DENDRITIC CELLS. Activation of the receptor on T-LYMPHOCYTES plays a role in their expansion, production of cytokines and survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Proteins prepared by recombinant DNA technology.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
Ubiquitously-expressed tetraspanin proteins that are found in late ENDOSOMES and LYSOSOMES and have been implicated in intracellular transport of proteins.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Tetraspanin proteins found associated with LAMININ-binding INTEGRINS. The CD151 antigens may play a role in the regulation of CELL MOTILITY.
A component of the B-cell antigen receptor that is involved in B-cell antigen receptor heavy chain transport to the PLASMA MEMBRANE. It is expressed almost exclusively in B-LYMPHOCYTES and serves as a useful marker for B-cell NEOPLASMS.
An encapsulated lymphatic organ through which venous blood filters.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. It may play a role in INFLAMMATION and immune regulation.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A class of enzymes involved in the hydrolysis of the N-glycosidic bond of nitrogen-linked sugars.
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
An alpha-integrin subunit found on lymphocytes, granulocytes, macrophages and monocytes. It combines with the integrin beta2 subunit (CD18 ANTIGEN) to form LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.
T-cell receptors composed of CD3-associated alpha and beta polypeptide chains and expressed primarily in CD4+ or CD8+ T-cells. Unlike immunoglobulins, the alpha-beta T-cell receptors recognize antigens only when presented in association with major histocompatibility (MHC) molecules.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
A melanosome-specific protein that plays a role in the expression, stability, trafficking, and processing of GP100 MELANOMA ANTIGEN, which is critical to the formation of Stage II MELANOSOMES. The protein is used as an antigen marker for MELANOMA cells.
A widely distributed cell surface transmembrane glycoprotein that stimulates the synthesis of MATRIX METALLOPROTEINASES. It is found at high levels on the surface of malignant NEOPLASMS and may play a role as a mediator of malignant cell behavior.
A general term for various neoplastic diseases of the lymphoid tissue.
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
Antigens associated with specific proteins of the human adult T-cell immunodeficiency virus (HIV); also called HTLV-III-associated and lymphadenopathy-associated virus (LAV) antigens.
An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
A widely expressed transmembrane glycoprotein that functions as a METASTASIS suppressor protein. It is underexpressed in a variety of human NEOPLASMS.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. Originally identified in the mouse, they are also found in other species including humans, and are expressed on brain neurons and other cells.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. At least six nuclear antigens have been identified.
A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
A cell line derived from cultured tumor cells.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A sex-specific cell surface antigen produced by the sex-determining gene of the Y chromosome in mammals. It causes syngeneic grafts from males to females to be rejected and interacts with somatic elements of the embryologic undifferentiated gonad to produce testicular organogenesis.
A cell adhesion molecule of the immunoglobulin superfamily that is expressed in ENDOTHELIAL CELLS and is involved in INTERCELLULAR JUNCTIONS.
Antigens stimulating the formation of, or combining with heterophile antibodies. They are cross-reacting antigens found in phylogenetically unrelated species.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
Antibodies obtained from a single clone of cells grown in mice or rats.
Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
The hepatitis B antigen within the core of the Dane particle, the infectious hepatitis virion.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
The sum of the weight of all the atoms in a molecule.
Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.
A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
A glycolipid, cross-species antigen that induces production of antisheep hemolysin. It is present on the tissue cells of many species but absent in humans. It is found in many infectious agents.
Elements of limited time intervals, contributing to particular results or situations.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
An inhibitory B7 antigen that has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 PROTEIN. CD274 antigen provides negative signals that control and inhibit T-cell responses and is found at higher than normal levels on tumor cells, suggesting its potential role in TUMOR IMMUNE EVASION.
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.
A melanosome-associated protein that plays a role in the maturation of the MELANOSOME.
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).
CD44 antigen, the main cell surface receptor for HA. Hyaladherin "Link domain signature and profile". PROSITE. December 2004. ... PMID 21937732. Barta E, Deák F, Kiss I (June 1993). "Evolution of the hyaluronan-binding module of link protein". Biochem. J. ... PMID 8318021. Kohda D, Morton CJ, Parkar AA, Hatanaka H, Inagaki FM, Campbell ID, Day AJ (September 1996). "Solution structure ... doi:10.1016/S0092-8674(00)80151-8. PMID 8797823. S2CID 16347386. Brissett NC, Perkins SJ (June 1996). "The protein fold of the ...
44 (10): 1690-9. PMID 14530488. Börjesson PK, Postema EJ, Roos JC, Colnot DR, Marres HA, van Schie MH, Stehle G, de Bree R, ... It is officially described as "immunoglobulin G1 (human-mouse monoclonal BIWA4 γ1-chain anti-human antigen CD44v6), disulfide ... Bivatuzumab (previously BIWA 4) is a humanized monoclonal antibody against CD44 v6. ... PMID 14506195. "Amendments to Previous Lists". WHO Drug Information. 16 (3). 2002. "Recommended INN: List 45" (PDF). WHO Drug ...
PMID 17135256. Thomas SN, Zhu F, Schnaar RL, Alves CS, Konstantopoulos K (Jun 2008). "Carcinoembryonic antigen and CD44 variant ... In humans, the CD44 antigen is encoded by the CD44 gene on Chromosome 11. CD44 has been referred to as HCAM (homing cell ... PMID 7524735. Alves CS, Burdick MM, Thomas SN, Pawar P, Konstantopoulos K (Apr 2008). "The dual role of CD44 as a functional P- ... PMID 19200980. Wang SJ, Wong G, de Heer AM, Xia W, Bourguignon LY (Aug 2009). "CD44 variant isoforms in head and neck squamous ...
PMID 11274010. Thomas SN, Zhu F, Schnaar RL, Alves CS, Konstantopoulos K (Jun 2008). "Carcinoembryonic antigen and CD44 variant ... PMID 10202129. Carcinoembryonic Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) CEA at Lab Tests ... PMID 19581728. Gold P, Freedman SO (March 1965). "DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY ... PMID 7863220. Duffy, Michael J. (April 2001). "Carcinoembryonic Antigen as a Marker for Colorectal Cancer: Is It Clinically ...
PMID 11238599. CD43+antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human SPN genome location ... proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2". J ... PMID 10908570. van den Berg TK, Nath D, Ziltener HJ, et al. (2001). "Cutting edge: CD43 functions as a T cell counterreceptor ... PMID 9616160. Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S (February 1998). "Ezrin/radixin/moesin ( ...
In breast cancer cells expressing CD44 and CD24, DHRS7B expression was observed to be down regulated. CD44 is an antigen found ... PMID 7984417. Honeth G, Bendahl PO, Ringnér M, Saal LH, Gruvberger-Saal SK, Lövgren K, Grabau D, Fernö M, Borg A, Hegardt C ( ... PMID 21959131. S2CID 16509924. Oppermann U, Kavanagh K, Guo K, Ng SS, Lukacik P, Wu X, Dubinina E, Shafqat N, Bray J, Marsden ... PMID 22121220. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S ...
CD44), Duffy (Duffy antigen/chemokine receptor or Fy), Scianna (ERMAP), MN (glycophorin A), Diego(band 3), P1, i, AnWj (CD44) ... PMID 25724378. Arnaud L, Saison C, Helias V, Lucien N, Steschenko D, Giarratana MC, Prehu C, Foliguet B, Montout L, de Brevern ... PMID 28180284. Borg J, Papadopoulos P, Georgitsi M, Gutiérrez L, Grech G, Fanis P, Phylactides M, Verkerk AJ, van der Spek PJ, ... Antigens on RBC membrane, and some of which might overlap with KLF1 mutations causing the fraction of hereditary persistence of ...
PMID 1314815.CS1 maint: multiple names: authors list (link) Maiti, A., Maki, G. & Johnson P. (1998). "TNF-α induction of CD44- ... "Striking similarities between antigen receptor J pieces and sequence in the second chain of the murine CD8 antigen". Nature. ... PMID 1314815.CS1 maint: multiple names: authors list (link) Maiti, A., Maki, G. & Johnson P. (1998). "TNF-α induction of CD44- ... PMID 9794764.CS1 maint: multiple names: authors list (link) Ruffell, B., Poon, G.F.T., Lee, S.S.M., Brown, K.L., Tjew, S-L., ...
PMID 11278857. Lim SH, Kwon SK, Lee MK, Moon J, Jeong DG, Park E, Kim SJ, Park BC, Lee SC, Ryu SE, Yu DY, Chung BH, Kim E, ... FYN has been shown to interact with: ADD2, BCAR1, C-Raf, CBLC, CD36, CD44, CDH1, CHRNA7, CTNND1, CBL, CSF1R, DLG4, Dystroglycan ... "Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular ... PMID 12458214. Chan B, Lanyi A, Song HK, Griesbach J, Simarro-Grande M, Poy F, Howie D, Sumegi J, Terhorst C, Eck MJ (February ...
By modifying CD44 antigens using glycosyltransferase-programmed stereosubstitution (GPS), the HCELL expression on the surfaces ... PMID 26933169. Slovin, S.; et al. (2005). "Special Feature: Glycobiology Of Xenotransplantation And Cancer Part I". Nature. ... PMID 10052355. Hudak, J.; Bertozzi, C. (2014). "Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine". ... PMID 24269151. Sackstein, R. (Jul 2009). "Glycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: engineering ...
Antigen-presenting cells accumulate near high endothelial venules to process soluble antigens. Antigens are also presented on ... PMID 19644499. Campbell, J. J.; Bowman, E. P.; Murphy, K.; Youngman, K. R.; Siani, M. A.; Thompson, D. A.; Wu, L.; Zlotnik, A ... a homologue of CD44. These molecules allow the entry of hematopoietic cells into the lymphatic vessels. During an inflammatory ... PMID 19644499. Mueller, S. N.; Germain, R. N. (2009). "Stromal cell contributions to the homeostasis and functionality of the ...
PMID 16454711. Riberdy JM, Newcomb JR, Surman MJ, Barbosa JA, Cresswell P (December 1992). "HLA-DR molecules from an antigen- ... "The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44". ... PMID 3866610. Claesson L, Peterson PA (June 1983). "Association of human gamma chain with class II transplantation antigens ... HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster ...
PMID 12447971. S2CID 39674808. Gilliam DT, Menon V, Bretz NP, Pruszak J (March 2017). "The CD24 surface antigen in neural ... Buess M, Rajski M, Vogel-Durrer BM, Herrmann R, Rochlitz C (October 2009). "Tumor-endothelial interaction links the CD44(+)/ ... CD24+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... Tissue Antigens. 75 (6): 696-700. doi:10.1111/j.1399-0039.2010.01447.x. PMID 20230526. Honeth G, Bendahl PO, Ringnér M, Saal LH ...
CD44 Carcinoembryonic antigens CEACAM1 CEACAM3 CEACAM4 CEACAM5 CEACAM6 CEACAM7 CEACAM8 CEACAM16 CEACAM18 CEACAM19 CEACAM20 ... PMID 19521399. Royet J, Gupta D, Dziarski R (December 2011). "Peptidoglycan recognition proteins: modulators of the microbiome ... Antigen Antigenicity Immunogen Superantigen Allergen Hapten Epitope Linear Conformational Mimotope Tumor antigen Antigen- ... PMID 22076558. S2CID 5266193. Immunologyat Wikipedia's sister projects Definitions from Wiktionary Media from Wikimedia Commons ...
PMID 12808028. Aziz KA (Aug 2003). "CD44 mediates polymorphonuclear leukocyte motility on hyaluronan". Saudi Medical Journal. ... is a new immunogenic leukemia-associated antigen in acute and chronic myeloid leukemia". Experimental Hematology. 30 (9): 1029- ... RHAMM is less well studied than the main hyaluronan (HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors ... PMID 9533523. Wang Z, Wu Y, Wang H, Zhang Y, Mei L, Fang X, Zhang X, Zhang F, Chen H, Liu Y, Jiang Y, Sun S, Zheng Y, Li N, ...
PMID 16454711.. *Riberdy J.M., Newcomb J.R., Surman M.J., Barbosa J.A., Cresswell P. HLA-DR molecules from an antigen- ... The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44 (англ ... PMID 3866610.. *Claesson L., Peterson P.A. Association of human gamma chain with class II transplantation antigens during ... PMID 24818664. *↑ Shan Z.X., Lin Q.X., Deng C.Y., Tan H.H., Kuang S.J., Xiao D.Z., Zhu J.N., Fu Y.H., Yu X.Y. [Identification ...
PMID 16179429. Muramatsu T, Muramatsu H (2004). "Carbohydrate antigens expressed on stem cells and early embryonic cells". ... CD34 CD44 NCAM (CD56) CD73 CD9 CD90 CDCP1 Circulating anticoagulants protein C (PC) CK19 CLV3 cyclic CMP ECMA-7 EDR1 EEC FGF-4 ... PMID 16914687. van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, ... PMID 10648408. Archived from the original on 1 August 2012. Zhou L, Wei X, Cheng L, Tian J, Jiang JJ (March 2007). "CD133, one ...
PMID 19842219. Ferrandina G, Martinelli E, Petrillo M, Prisco MG, Zannoni G, Sioletic S, Scambia G (July 2009). "CD133 antigen ... CD44, and CD166 in colorectal cancer". Cancer Investigation. 27 (8): 844-50. doi:10.1080/07357900902744502. PMID 19626493. ... PMID 19744348. Li CY, Li BX, Liang Y, Peng RQ, Ding Y, Xu DZ, Zhang X, Pan ZZ, Wan DS, Zeng YX, Zhu XF, Zhang XS (July 2009). " ... PMID 19430532. Wu X, Spitz MR, Lee JJ, Lippman SM, Ye Y, Yang H, Khuri FR, Kim E, Gu J, Lotan R, Hong WK (July 2009). "Novel ...
PMID 20879168. †Hu D, †Ikizawa K, Lu L, Sanchirico ME, Shinohara ML, Cantor H. Analysis of regulatory CD8 cells in mice ... Boyse EA, Old LJ, Stockert E. An approach to the mapping of antigens on the cell surface. Proc Natl Acad Sci USA 1968;60:886. ... Weber GF, Ashkar S, Glimcher MJ, Cantor H. Receptor-ligand interaction between Osteopontin (Eta-1) and CD44. Science 271: 509- ... J Exp Med 145: 1-9. Rao A, Ko WW, Faas SJ, Cantor H. Binding of antigen in the absence of histocompatibility proteins by ...
PMID 2455897. Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE (May 1989). "The CD4 and CD8 antigens are coupled ... PMID 8551220. Taher TE, Smit L, Griffioen AW, Schilder-Tol EJ, Borst J, Pals ST (February 1996). "Signaling through CD44 is ... PMID 8576267. Ilangumaran S, Briol A, Hoessli DC (May 1998). "CD44 selectively associates with active Src family protein ... PMID 11904433. Buffière A, Accogli T, Saint-Paul L, Lucchi G, Uzan B, Ballerini P, Bastie JN, Delva L, Pflumio F, Quéré R ( ...
PMID 7240787. Bruhn HD, Heimburger N (1976). "Factor-VIII-related antigen and cold-insoluble globulin in leukemias and ... PMID 6480605. Jalkanen S, Jalkanen M (February 1992). "Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of ... PMID 7499434. Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 ... PMID 26759148. Lee JC, Jeng YM, Su SY, Wu CT, Tsai KS, Lee CH, Lin CY, Carter JM, Huang JW, Chen SH, Shih SR, Mariño-Enríquez A ...
PMID 23589020. Alexandropoulos, Konstantina; Danzl, Nichole M. (28 March 2012). "Thymic epithelial cells: antigen presenting ... Double negative (DN) T cells, as a progenitors with CD44 and CD25 expression but lack of CD4 and CD8 coreceptor expression, are ... PMID 28226225. Sun, Lina; Li, Hongran; Luo, Haiying; Zhao, Yong (2014). "Thymic Epithelial Cell Development and Its Dysfunction ... PMID 22591984. Sun, Lina; Luo, Haiying; Li, Hongran; Zhao, Yong (15 April 2013). "Thymic epithelial cell development and ...
PMID 21288770. Marusina AI, Ono Y, Merleev AA, Shimoda M, Ogawa H, Wang EA, et al. (February 2017). "+ virtual memory: Antigen- ... They also have intermediate to high expression of CD44. These memory T cells lack lymph node-homing receptors and are thus ... PMID 23947354. Gattinoni L, Lugli E, Ji Y, Pos Z, Paulos CM, Quigley MF, et al. (September 2011). "A human memory T cell subset ... PMID 10537110. Akbar AN, Terry L, Timms A, Beverley PC, Janossy G (April 1988). "Loss of CD45R and gain of UCHL1 reactivity is ...
PMID 27270402. White, Jason T.; Cross, Eric W.; Kedl, Ross M. (June 2017). "Antigen-inexperienced memory CD8+T cells: where ... CD44 or CD69; and the absence of memory CD45RO isoform. They also express functional IL-7 receptors, consisting of subunits IL- ... When a recognized antigen binds to the T cell antigen receptor (TCR) located in the cell membrane of Th0 cells, these cells are ... PMID 11175858. van den Broek, Theo; Borghans, José A. M.; van Wijk, Femke (2018-03-08). "The full spectrum of human naive T ...
A group of diencephalic cells that express the cell surface antigen stage-specific embryonic antigen (SSEA)-1 and CD44 will ... PMID 21664576. Wang J, Chan CK, Taylor JS, Chan SO (June 2008). "Localization of Nogo and its receptor in the optic pathway of ... PMID 25504540. Petros TJ, Rebsam A, Mason CA (2008-01-01). "Retinal axon growth at the optic chiasm: to cross or not to cross ... PMID 18366734. Herrera E, Marcus R, Li S, Williams SE, Erskine L, Lai E, Mason C (November 2004). "Foxd1 is required for proper ...
PMID 8413654. S2CID 4321353. Shi X, Leng L, Wang T, Wang W, Du X, Li J, et al. (October 2006). "CD44 is the signaling component ... Bacterial antigens stimulate white blood cells to release MIF into the blood stream. The circulating MIF binds to CD74 on other ... PMID 32655566. Shen L, Hu J, Lu H, Wu M, Qin W, Wan D, et al. (April 2003). "The apoptosis-associated protein BNIPL interacts ... PMID 14502271. Günther S, Fagone P, Jalce G, Atanasov AG, Guignabert C, Nicoletti F (February 2019). "Role of MIF and D-DT in ...
... stage-specific embryonic antigen-1), EGFR and CD44. The use of CD133 for identification of brain tumor stem-like cells may be ... PMID 28716722. Cao W, Li M, Liu J, Zhang S, Noordam L, Verstegen MM, Wang L, Ma B, Li S, Wang W, Bolkestein M, Doukas M, Chen K ... Both CD44+CD24− and CD44+CD24+ cell populations are tumor initiating cells; however, CSC are most highly enriched using the ... PMID 20074520. Deng S, Yang X, Lassus H, Liang S, Kaur S, Ye Q, Li C, Wang LP, Roby KF, Orsulic S, Connolly DC, Zhang Y, ...
... and tumor antigens". Blood. 107 (1): 151-8. doi:10.1182/blood-2005-03-1112. PMID 16166594. Mantovani A, Garlanda C, Bottazzi B ... closely related to the adhesion receptor CD44". The Journal of Cell Biology. 116 (2): 545-57. doi:10.1083/jcb.116.2.545. PMC ... PMID 9407058. Garlanda C, Hirsch E, Bozza S, Salustri A, De Acetis M, Nota R, Maccagno A, Riva F, Bottazzi B, Peri G, Doni A, ... PMID 15977234. S2CID 24762210. Azzurri A, Sow OY, Amedei A, Bah B, Diallo S, Peri G, Benagiano M, D'Elios MM, Mantovani A, Del ...
PMID 23315069. Chiu, P. C. N.; Wong, B. S. T.; Chung, M. -K.; Lam, K. K. W.; Pang, R. T. K.; Lee, K. -F.; Sumitro, S. B.; Gupta ... Sialyl Lewis X is also one of the most important blood group antigens and is displayed on the terminus of glycolipids that are ... CD43 or CD44. This sialyl-Lewisx mediated binding to selectins allows circulating leukocytes to stick to and roll along ... PMID 1362195. S2CID 8602651. Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology ( ...
PMID 17825415. doi:10.1016/j.molimm.2007.03.028.. *^ Dushek O, van der Merwe PA. An induced rebinding model of antigen ... 在DN2阶段(CD44+CD25+),细胞上调RAG1/2并重排TCR(T细胞受体)-β基因座,V-D-J序列和恒定区序列,目的是产生一个有功能的TCR-β链。当细胞经过DN3阶段(CD44-CD25+)时,细胞将会和TCRβ一起表达一个未经重排的α-链 ... PMID 22623779. doi:10.1128/JVI.00889-12.. *^ Wherry EJ. T cell exhaustion. Nature Immunology. June 2011, 12 (6): 492-9. PMID ... PMID 17353286. doi:10.1128/IAI.01178-06.. *^ 16.0 16.1
PMID 12408045. doi:10.1159/000066854. *Stohl W (2005). "A therapeutic role for BLyS antagonists.". Lupus 13 (5): 317-22. PMID ... 2000). "Characterization of a new member of the TNF family expressed on antigen presenting cells.". Biol. Chem. 380 (12): 1443- ... CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50 ... PMID 12370363. Cite uses deprecated parameter ,month=. (help) *↑ Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L, Pan CH, ...
PMID 10192335.. External links[edit]. *CD30+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) ... I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by ... PMID 8999898.. *^ a b c Ansieau S, Scheffrahn I, Mosialos G, Brand H, Duyster J, Kaye K, Harada J, Dougall B, Hübinger G, Kieff ... PMID 29761078.. *^ a b Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T (Jan ...
Lymphocyte homing receptor: CD44. *L-selectin. *integrin (VLA-4, LFA-1). *Carcinoembryonic antigen ... PMID 16648968.. *^ a b Borsig L, Wong R, Feramisco J, Nadeau DR, Varki NM, Varki A (March 2001). "Heparin and cancer revisited ... PMID 21532885.. *^ "Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease". New England Journal Medicine. ... PMID 2472431.. *^ Herrmann SM, Ricard S, Nicaud V, Mallet C, Evans A, Ruidavets JB, Arveiler D, Luc G, Cambien F (August 1998 ...
Lymphocyte homing receptor: CD44. *L-selectin. *integrin (VLA-4, LFA-1). *Carcinoembryonic antigen ... PMID 20972252.. *^ Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, et al. (2016). "Frequency and Complexity of ... PMID 9615235.. *^ Suzuki S, Sano K, Tanihara H (Apr 1991). "Diversity of the cadherin family: evidence for eight new cadherins ... PMID 10861224.. *. Blaschke S, Mueller CA, Markovic-Lipkovski J, Puch S, Miosge N, Becker V, Mueller GA, Klein G (Oct 2002). " ...
PMID 23028701.. *^ Alberts B (Dec 23, 2011). "Retraction". Science. 334 (6063): 1636. doi:10.1126/science.334.6063.1636-a. PMID ... Prostate specific membrane antigen is a transmembrane carboxypeptidase and exhibits folate hydrolase activity.[75] This protein ... Relative frequency of loss of E-cadherin and CD44 has also been observed. ... PMID 1104900.. *^ a b c Arnst, Catherine (2007-06-13). "A Gender Gap in Cancer". Businessweek.com. Archived from the original ...
PMID 2540389.. *Seligman P. A., Butler C. D., Massey E. J., etal. The p97 antigen is mapped to the q24-qter region of ... PMID 3010712.. *Le Beau M. M., Diaz M. O., Plowman G. D., etal. Chromosomal sublocalization of the human p97 melanoma antigen. ... PMID 3754536.. *Plowman G. D., Brown J. P., Enns C. A., etal. Assignment of the gene for human melanoma-associated antigen p97 ... PMID 1633859.. *Rose T. M., Plowman G. D., Teplow D. B., etal. Primary structure of the human melanoma-associated antigen p97 ( ...
PMID 2342461.. *. Kamarck ME, Elting JJ, Hart JT, et al. (1987). "Carcinoembryonic antigen family: expression in a mouse L-cell ... PMID 2309067.. *. Schrewe H, Thompson J, Bona M, et al. (1990). "Cloning of the complete gene for carcinoembryonic antigen: ... PMID 10816511.. *. Boehm MK, Perkins SJ (2000). "Structural models for carcinoembryonic antigen and its complex with the single ... PMID 3220478.. *. Zimmermann W, Weber B, Ortlieb B, et al. (1988). "Chromosomal localization of the carcinoembryonic antigen ...
PMID 19118589.. *^ Kniffin CL (2013). "OMIM entry # 614490 - BLOOD GROUP, JUNIOR SYSTEM; JR". Online Mendelian Inheritance in ... The protein also carries the Jr(a) antigen, which defines the Junior blood group system.[9] ... PMID 8894702.. *^ Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK, Ross DD (Jan 1999). "A multidrug resistance ... PMID 16562373.. *. Schmitz G, Langmann T, Heimerl S (2002). "Role of ABCG1 and other ABCG family members in lipid metabolism". ...
PMID 10508765.. *van Rhenen A., van Dongen G. A., Kelder A., et al. The novel AML stem cell associated antigen CLL-1 aids in ... PMID 16239426.. *Bakker A. B., van den Oudenrijn S., Bakker A. Q., et al. C-type lectin-like molecule-1: a novel myeloid cell ... PMID 16838277.. *Chen C. H., Floyd H., Olson N. E., et al. Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic- ... PMID 12945048.. *Strausberg R. L., Feingold E. A., Grouse L. H., et al. Generation and initial analysis of more than 15,000 ...
Lymphocyte homing receptor: CD44. *L-selectin. *integrin (VLA-4, LFA-1). *Carcinoembryonic antigen ... PMID 7542250.. *^ a b c d Hazan RB, Norton L (April 1998). "The epidermal growth factor receptor modulates the interaction of E ... PMID 12427869.. *^ a b c d Kinch MS, Clark GJ, Der CJ, Burridge K (July 1995). "Tyrosine phosphorylation regulates the ... PMID 12707304.. *^ a b c Piedra J, Miravet S, Castaño J, Pálmer HG, Heisterkamp N, García de Herreros A, Duñach M (April 2003 ...
PMID 11714836.. *. Ebert LM, McColl SR (2002). "Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated ... PMID 19249008.. *^ Rubie C (Feb 2014). "Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer ... PMID 9186513.. *. Liao F, Alderson R, Su J, et al. (1997). "STRL22 is a receptor for the CC chemokine MIP-3alpha". Biochem. ... PMID 8886020.. *. Liao F, Lee HH, Farber JM (1997). "Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor ...
PMID 11278338.. *^ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). ... It is also called Lewis x and SSEA-1 (stage-specific embryonic antigen 1) and represents a marker for murine pluripotent stem ... PMID 1362195.. *^ Nakayama F, Nishihara S, Iwasaki H, Kudo T, Okubo R, Kaneko M, Nakamura M, Karube M, Sasaki K, Narimatsu H ( ... CD15 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ...
"CD antigens 2001". Journal of Leukocyte Biology. 70 (5): 685-90. PMID 11698486.. ... A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine. 176 (2): 327-37. doi:10.1084 ... A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine. 176 (2): 327-37. doi:10.1084 ... antigen processing and presentation of exogenous peptide antigen via MHC class II. ...
2001). "Tissue distribution of the human CD97 EGF-TM7 receptor". Tissue Antigens 57 (4): 325-31. PMID 11380941. doi:10.1034/j. ... CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50 ... PMID 15668483. Cite uses deprecated parameter ,month=. (help). *Kwakkenbos MJ; Kop EN; Stacey M et al. (2004). "The EGF-TM7 ... PMID 8955192. Cite uses deprecated parameter ,author-separator=. (help). *Hamann J, Vogel B, van Schijndel GM, van Lier RA ( ...
PMID 29658845. doi:10.1056/NEJMoa1801946.. *^ 139.0 139.1 139.2 139.3 139.4 Syn NL, Teng MW, Mok TS, Soo RA. De-novo and ... 嵌合抗原受體T細胞免疫療法(Chimeric Antigen Receptor T-Cell Immunotherapy)乃是先取得患者自身的T細胞後,在體外以基因工程的技術,使T細胞具有辨識癌細胞的能力後,再回輸到患者身上。被改造後的T細胞即稱為嵌合抗 ... 也可能会表达CD44[60]。 ... PMID 24609921. doi:10.1136/bmj.g1970.. *^ 93.0 93.1 93.2 ... PMID 22391408. doi:10.1102/1470-7330.2012.
PMID 14764622.. *^ a b c d e f Kelly, J. A.; Moser, K. L.; Harley, J. B. (2002-10-01). "The genetics of systemic lupus ... Monocytes isolated from whole blood of people with SLE show reduced expression of CD44 surface molecules involved in the uptake ... In close proximity to TBM, follicular dendritic cells (FDC) are localised in GC, which attach antigen material to their surface ... 16 (3): 250-2. PMID 9631744.. *^ a b c d e f Vasudevan AR, Ginzler EM (August 4, 2009). "Established and novel treatments for ...
PMID 23106920. S2CID 206157070.. *^ "Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)".. ... PMID 11864709.. *^ Shattil, S J; O'Toole T; Eigenthaler M; Thon V; Williams M; Babior B M; Ginsberg M H (November 1995). "Beta ... PMID 7593198.. *^ Patil, S; Jedsadayanmata A; Wencel-Drake J D; Wang W; Knezevic I; Lam S C (October 1999). "Identification of ... PMID 11932255.. *^ Naik, U P; Patel P M; Parise L V (February 1997). "Identification of a novel calcium-binding protein that ...
2001). „Tissue distribution of the human CD97 EGF-TM7 receptor". Tissue Antigens. 57 (4): 325-31. PMID 11380941. doi:10.1034/j. ... CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50 ... PMID 7636245.. *^ Hamann J, Hartmann E, van Lier RA (1996). „Structure of the human CD97 gene: exon shuffling has generated a ... PMID 12414513. doi:10.1016/S0002-9440(10)64443-4.. *. Visser L; de Vos AF; Hamann J; et al. (2003). „Expression of the EGF-TM7 ...
PMID 17825415.. *^ Dushek O, van der Merwe PA (2014). "An induced rebinding model of antigen discrimination". Trends Immunol. ... The newly arrived CLP cells are CD4-CD8-CD44+CD25-ckit+ cells, and are termed early thymic progenitors (ETP) cells.[3] These ... PMID 24450998.. *^ Huang S, Martin E, Kim S, Yu L, Soudais C, Fremont DH, Lantz O, Hansen TH (May 2009). "MR1 antigen ... PMID 22623779.. *^ Wherry EJ (June 2011). "T cell exhaustion". Nature Immunology. 12 (6): 492-9. doi:10.1038/ni.2035. PMID ...
PMID 7517401. Cite uses deprecated parameter ,month=. (help) *↑ Bourguignon, L Y; Zhu H, Shao L, Chen Y W (March 2001). "CD44 ... "The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta- ... PMID 11724572. doi:10.1021/bi011247r. Cite uses deprecated parameter ,month=. (help) *↑ Teo, A K; Oh H K, Ali R B, Li B F ( ... PMID 11980671. Cite uses deprecated parameter ,month=. (help) *↑ 24,0 24,1 Angers-Loustau, A; Côté J F, Charest A, Dowbenko D, ...
PMID 23475323.. *^ Min HS, Kim JE, Lee MH, Song HK, Kang YS, Lee MJ, Lee JE, Kim HW, Cha JJ, Chung YY, Hyun YY, Han JY, Cha DR ... "Direct association of adenosine deaminase with a T cell activation antigen, CD26". Science. 261 (5120): 466-9. doi:10.1126/ ... PMID 17940427.. *^ Raj VS, Mou H, Smits SL, Dekkers DH, Müller MA, Dijkman R, Muth D, Demmers JA, Zaki A, Fouchier RA, Thiel V ... PMID 24687121.. *^ Havre PA, Abe M, Urasaki Y, Ohnuma K, Morimoto C, Dang NH (2008). "The role of CD26/dipeptidyl peptidase IV ...
PMID 7561026.. *^ Grewal, IS; Xu, J; Flavell, RA (7 December 1995). "Impairment of antigen-specific T-cell priming in mice ... PMID 14568885.. *^ Wang JH, Zhang YW, Zhang P, Deng BQ, Ding S, Wang ZK, Wu T, Wang J (September 2013). "CD40 ligand as a ... PMID 11229815.. *^ Grewal, IS; Flavell, RA (1998). "CD40 and CD154 in cell-mediated immunity". Annual Review of Immunology. 16 ... PMID 1281189.. *^ Lederman S, Yellin MJ, Cleary AM, Pernis A, Inghirami G, Cohn LE, Covey LR, Lee JJ, Rothman P, Chess L (March ...
antigen processing and presentation of peptide antigen via MHC class I. • antigen processing and presentation of exogenous ... PMID 18285328.. Используется устаревший параметр ,month=. (справка). .mw-parser-output cite.citation{font-style:inherit}.mw- ... antigen processing and presentation of exogenous peptide antigen via MHC class I. • lipoprotein transport. • negative ... peptide antigen via MHC class I, TAP-dependent. • platelet degranulation. • MyD88-dependent toll-like receptor signaling ...
Lymphocyte homing receptor: CD44. *L-selectin. *integrin (VLA-4, LFA-1). *Carcinoembryonic antigen ... PMID 23555021.. *^ Eibl RH, Benoit M (2004). "Molecular resolution of cell adhesion forces". IEE Proc Nanobiotechnol. 151 (3): ... PMID 15548573.. *. Wu TC (2007). "The role of vascular cell adhesion molecule-1 in tumor immune evasion". Cancer Res. 67 (13): ... PMID 12082081.. *^ ZX Yang; et al. (2013). "CD106 identifies a subpopulation of mesenchymal stem cells with unique ...
PMID 15780119.. *Hu C., Xiong J., Zhang L., Huang B., Zhang Q., Li Q., Yang M., Wu Y., Wu Q., Shen Q., Gao Q., Zhang K., Sun Z ... uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate (англ.) // Blood (англ ... PMID 24337540. *↑ Mitkin N.A., Hook C.D., Schwartz A.M., Biswas S., Kochetkov D.V., Muratova A.M., Afanasyeva M.A., Kravchenko ... PMID 8978608. *↑ Biswas S., Sengupta S., Roy Chowdhury S., Jana S., Mandal G., Mandal P.K., Saha N., Malhotra V., Gupta A., ...
PMID 1547508.. *^ Devine L, Sun J, Barr M, Kavathas P (1999). "Orientation of the Ig domains of CD8 alpha beta relative to MHC ... In addition to aiding with cytotoxic T cell antigen interactions the CD8 co-receptor also plays a role in T cell signaling. The ... PMID 9916707.. *^ "CD8 alpha - Marker for cytotoxic T Lymphocytes". Archived from the original on 21 September 2015. Retrieved ... the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell antigen interactions. ...
PMID 11806999.. *^ a b Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, ... antigen binding. • virus receptor activity. • protein binding. • transmembrane signaling receptor activity. • identical protein ... PMID 11689425.. *^ Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, ... PMID 9091591.. *. Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, van Schaik S, Notarangelo L, Geha R, Roncarolo MG, Oettgen ...
PMID 17199736. doi:10.1111/j.1440-1827.2007.02049.x. *Bao L, Gerard NP, Eddy RL et al. (1992). "Mapping of genes for the human ... CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50 ... 1996). "CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human ... PMID 7649993. doi:10.1074/jbc.270.34.19828. *Wennogle LP, Conder L, Winter C et al. (1994). "Stabilization of C5a receptor--G- ...
Signaling through the leukocyte function-associated antigen 1 (LFA-1) molecule has previously been shown to induce homotypic ... PMID: 7595055 Owner: NLM Status: MEDLINE Abstract/OtherAbstract: Signaling through the leukocyte function-associated antigen 1 ... 0/Alkaloids; 0/Antigens, CD2; 0/Antigens, CD3; 0/Antigens, CD44; 0/Enzyme Inhibitors; 0/Lymphocyte Function-Associated Antigen- ... Antigens, CD2 / metabolism. Antigens, CD3 / physiology. Antigens, CD44 / physiology*. Cell Membrane / ultrastructure. Cell Size ...
PMID. 14535589 (Publication Type: Journal Article) Chemical References. *Antigens, CD44. *Antigens, Neoplasm ...
PMID 11274010. Thomas SN, Zhu F, Schnaar RL, Alves CS, Konstantopoulos K (Jun 2008). "Carcinoembryonic antigen and CD44 variant ... PMID 10202129. Carcinoembryonic Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) CEA at Lab Tests ... PMID 19581728. Gold P, Freedman SO (March 1965). "DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY ... PMID 7863220. Duffy, Michael J. (April 2001). "Carcinoembryonic Antigen as a Marker for Colorectal Cancer: Is It Clinically ...
CD44 antigen, the main cell surface receptor for HA. Hyaladherin "Link domain signature and profile". PROSITE. December 2004. ... PMID 21937732. Barta E, Deák F, Kiss I (June 1993). "Evolution of the hyaluronan-binding module of link protein". Biochem. J. ... PMID 8318021. Kohda D, Morton CJ, Parkar AA, Hatanaka H, Inagaki FM, Campbell ID, Day AJ (September 1996). "Solution structure ... doi:10.1016/S0092-8674(00)80151-8. PMID 8797823. S2CID 16347386. Brissett NC, Perkins SJ (June 1996). "The protein fold of the ...
PMID 17135256. Thomas SN, Zhu F, Schnaar RL, Alves CS, Konstantopoulos K (Jun 2008). "Carcinoembryonic antigen and CD44 variant ... In humans, the CD44 antigen is encoded by the CD44 gene on Chromosome 11. CD44 has been referred to as HCAM (homing cell ... PMID 7524735. Alves CS, Burdick MM, Thomas SN, Pawar P, Konstantopoulos K (Apr 2008). "The dual role of CD44 as a functional P- ... PMID 19200980. Wang SJ, Wong G, de Heer AM, Xia W, Bourguignon LY (Aug 2009). "CD44 variant isoforms in head and neck squamous ...
Hepatocellular antigen recognition triggers effector functions in a diapedesis-independent manner and is inhibited by the ... circulating CD8 TE arrest within liver sinusoids by docking onto platelets previously adhered to sinusoidal hyaluronan via CD44 ... PMID:. 25892224. DOI:. 10.1016/j.cell.2015.03.005. [Indexed for MEDLINE] Free full text ... CD8 TE actively crawl along liver sinusoids and probe sub-sinusoidal hepatocytes for the presence of antigens by extending ...
Murine memory cells are CD44 high and low in the expression of activation markers such as CD25 (IL-2R), whereas human memory ... Reencounter with the same antigen can expand the population to a new, stable, higher level and generate a separate population ... PMID:. 9597129. DOI:. 10.1146/annurev.immunol.16.1.201. [Indexed for MEDLINE] Share ... of CD44 high effectors that may be required for protection, while competition from other antigens can drive it down to a lower ...
Antigen-inexperienced T cells express homing receptors CD62L and CCR7, but lack expression of activation markers CD44 and CD95 ... Overview of mouse T cell differentiation from naive to memory T cells (PMID: 24258910, 26999211). ... The particles mimic antigen-presenting cells and, when loaded with CD3 and CD28 antibodies and applied in a specific bead-to- ... Most clonally expanded antigen-specific T cells die after the termination of the immune response, but a small percentage ...
PMID: 29682524. *CD44 regulated TLR2 responses in human macrophages, whereby a reduction in CD44 levels or engagement of CD44 ... LHR; BA-1; CD 44; CD44; CD44 antigen; CD44 molecule (Indian blood group); CD44 molecule; CD44_HUMAN; CDw44; CDW44 antigen; Cell ... Recombinant Human CD44 antigen(CD44),partial ( E.coli-CSB-EP004938HU ). *Recombinant Human CD44 antigen(CD44),partial ( E.coli- ... Recombinant Human CD44 antigen(CD44),partial ( E.coli-CSB-EP004938HU2 ). *Recombinant Human CD44 antigen(CD44) ( in vitro E. ...
Antigen-inexperienced T cells express homing receptors CD62L and CCR7, but lack expression of activation markers CD44 and CD95 ... Overview of mouse T cell differentiation from naive to memory T cells (PMID: 24258910, 26999211). ... The antigens that activate γ/δ T cells and their specific function are still largely unknown. They recognize antigens without ... T cell activation can be either antigen-specific, by recognition of the cognate antigen, or polyclonal via, e.g., antibody- ...
Since the CD44 variant 6(v6) molecule has been noted as a marker for tumor metastasis and prognosis in several tumors, we ... PMID: 9849582 * PMCID: PMC5921704 * DOI: 10.1111/j.1349-7006.1998.tb00493.x Abstract Since the CD44 variant 6(v6) molecule has ... Expression of CD44 variants and its association with survival in pancreatic cancer Jpn J Cancer Res. 1998 Oct;89(10):1033-40. ... On the other hand, expression of total CD44 (including CD44v, as well as CD44s) was observed in both tumors and adjacent normal ...
Chemical-registry-number] 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / CD44v6 antigen; 0 / Glycoproteins ... PMID = 17357203.001).. *[ISSN] 1107-0625. *[Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of ... MeSH-major] Antigens, CD44 / biosynthesis. Biomarkers, Tumor. Glycoproteins / biosynthesis. Uterine Cervical Neoplasms / blood ...
Antigens, CD44 / physiology. Apoptosis. Cell Differentiation. Leukemia, Myeloid, Acute / pathology. *[MeSH-minor] Cell Division ... PMID. Show me only articles for these PMIDs (PubMed IDs): + Semantic-Type. And with semantic types: A. Entity. A1. Physical ... Charrad RS, Gadhoum Z, Qi J, Glachant A, Allouche M, Jasmin C, Chomienne C, Smadja-Joffe F: Effects of anti-CD44 monoclonal ... Blood Group Antigens. Leukemia, Myeloid, Acute / drug therapy. *MedlinePlus Health Information. consumer health - Acute Myeloid ...
Cain DW, Schreiber TH, Dimitroff CJ, Chung C, Otero J, Sackstein R. . CD44/HCELL is an E- and L-selectin ligand on murine ... Interestingly, a hallmark feature on the GC B cell surface is the stage-specific expression of a glycan moiety T antigen (TAg ... Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19491-6. PMID: 19889975. ... Dimitroff CJ, Lee JY, Sackstein R. . CD44 is the primary L-selectin ligand on human leukemias. Proc. AACR. 2001; 42:298. ...
We evaluated the consequences of perinatal exposure to low doses of BPA on immune-specific response to the food antigen ovalbum ... This result is in accordance with the increase of activated CD4(+)CD44(high)CD62L(low) T lymphocytes observed in spleen of BPA- ... We evaluated the consequences of perinatal exposure to low doses of BPA on immune-specific response to the food antigen ... PMID: 25085925 * DOI: 10.1096/fj.14-255380 Abstract The food contaminant bisphenol A (BPA) is pointed out as a risk factor in ...
PMID 16454711.. *Riberdy J.M., Newcomb J.R., Surman M.J., Barbosa J.A., Cresswell P. HLA-DR molecules from an antigen- ... The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44 (англ ... PMID 3866610.. *Claesson L., Peterson P.A. Association of human gamma chain with class II transplantation antigens during ... PMID 24818664. *↑ Shan Z.X., Lin Q.X., Deng C.Y., Tan H.H., Kuang S.J., Xiao D.Z., Zhu J.N., Fu Y.H., Yu X.Y. [Identification ...
PMID:·18388297·,. • Katoh S, Matsumoto N, Kawakita K, Tominaga A, Kincade PW, Matsukura S: A role for CD44 in an antigen‑ ... Anti-H/M CD44 PERCP-CY5.5,IM7. 特異性. The rat monoclonal antibody IM7 recognizes CD44 antigen, an 80-95 kDa transmembrane ... PMID:·16785522·,. • Legg JW, Lewis CA, Parsons M, Ng T, Isacke CM: A novel PKC‑regulated mechanism controls CD44 ezrin ... PMID:·7068175·,. • McKallip RJ, Do Y, Fisher MT, Robertson JL, Nagarkatti PS, Nagarkatti M: Role of CD44 in activation‑induced ...
PMID 11238599.. External links. *CD43+antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ... proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2". J ... PMID 2223062.. *↑ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2nd ed.). ... PMID 9616160.. *↑ Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S (February 1998). "Ezrin/radixin/moesin ...
PMID: 3731854 Free PMC article.. The prognostic impact of human leukocyte antigen (HLA) class I antigen abnormalities in ... PMID: 31257448. Characterizing CD44 regulatory microRNAs as putative therapeutic agents in human melanoma. Fänder J, Kielstein ... PMID: 15609325. Defects in the human leukocyte antigen class I antigen processing machinery in head and neck squamous cell ... doi: 10.1016/s1471-4906(03)00116-9. PMID: 12810110. Characterization of human lymphocyte antigen class I antigen-processing ...
Rabbit recombinant monoclonal CD44 antibody [EPR1013Y]. Validated in WB, IHC, Flow Cyt and tested in Human. Cited in 96 ... The expression of CD44 in MCF-7 is low (PMID: 25635866; PMID: 26005723). Jurkat does not express CD44 (PMID: 24127558). ... Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.. ... Anti-CD44 antibody [EPR1013Y] - BSA and Azide free (ab216647) *Anti-CD44 antibody [EPR1013Y] - Low endotoxin, Azide free ( ...
Ben-Sasson, S. Z., Le Gros, G., Conrad, D. H., Finkelman, F. D. & Paul, W. E. (1990) J. Immunol. 145 , 1127-1136. pmid:2143207 ... The frequency of IL-4+ cells among CD4+ CD44+ cells was 3.6% in the control Ig group and 1.4% in the anti-IL-2 group (Fig. 12, ... CD4 + Cells and Antigen-Presenting Cells (APCs). Naïve lymph node CD4+ T cells were purified by negative selection, and purity ... Henkel, G., Weiss, D. L., McCoy, R., Deloughery, T., Tara, D. & Brown, M. A. (1992) J. Immunol. 149 , 3239-3246. pmid:1431102 ...
Variable influence of self-antigens on T cell receptor Vβ usage. J. Immunol. 146:1134-1141, pmid:1825105.. ... and δ rearrangements during adult thymic developmentT cell receptor rearrangements are present in CD44+CD25+ Pro-T thymocytes. ... 1989) Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature. 342:559-561, pmid: ... 1992) Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature. 360:225-231, ...
This impairment is characterized by reduction in CD44 expression, IFN-gamma production, proliferation and cytotoxicity. However ... gamma serum levels and enhanced production of IL-10 and IFN-gamma in cultured splenocytes upon antigen restimulation. Finally, ... PMID: 20543052 Posted by THE SCOPE at 5:48 AM No comments: Email ThisBlogThis!Share to TwitterShare to FacebookShare to ... maturation and decreased effector functions in these mice are essentially downstream consequences of reduced number of antigen- ...
PMID: 26638028 * Hwang SH, Jung SH, Lee S, Choi S, Yoo SA, Park JH, Hwang D, Shim SC, Sabbagh L, Kim KJ, Park SH, Cho CS, Kim ... Shi X, Leng L, Wang T, Wang W, Du X, Li J, McDonald C, Chen Z, Murphy JW, Lolis E, Noble P, Knudson W, Bucala R: CD44 is the ... Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen- ... PMID: 23776208 * Sun H, Choo-Wing R, Sureshbabu A, Fan J, Leng L, Yu S, Jiang D, Noble P, Homer RJ, Bucala R, Bhandari V: A ...
The antitumor activity of CVS was reflected in antigen-specific, T-cell-mediated immunity. Both CD4 and CD8 T cells contributed ... CD44 bright, CD25+, CD54+, CD69+ or CD71+ in the lymph nodes. Thus, CVS induces T cell activation in peripheral lymph nodes in ... PMID: 9202743 [PubMed - indexed for MEDLINE]. ...
PubMed PMID:15063359.. * Mitoma J, Miyazaki T, Sutton-Smith M, Suzuki M, Saito H, Yeh JC, Kawano T, Hindsgaul O, Seeberger PH, ... PSGL-1 from the murine leukocytic cell line WEHI-3 is enriched for core 2-based O-glycans with sialyl Lewis x antigen. ... E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin αLβ2-mediated slow leukocyte rolling. ... PubMed PMID: 7688665.. *↑ Kakkar AK, Lefer DJ. Leukocyte and endothelial adhesion molecule studies in knockout mice. Curr Opin ...
B6.129(Cg)-Cd44tm1Hbg/J. PMID: 10528194. RRID: MGI:4942279. Biological sample. Crushed House dust mite (Der p 1: 1911.78 mcg/ ... Baseline responses to house dust mite (HDM) antigen can vary for several reasons. First, unlike peptide antigens or recombinant ... CD44 knockout (Cd44tm1Hbg/J) animals were purchased from Jackson Laboratory. All mice were bred and maintained in house in a ... All IL-10-producing CD4+ T cells irrespective of Foxp3 expression express high levels of CD44 (Figure 4G). CD44 is a receptor ...
Journal Article 2009; 30(Suppl 1): 106-111 PubMed PMID: 20027154 Keywords: Animals, Antigens, CD44:metabolism, Cell Line, Flow ... Journal Article 2017; 38(Suppl1): 5-9 PubMed PMID: 29200248 Citation OBJECTIVE: Management chronic inflammatory bowel disease ( ... Journal Article 2009; 30(Suppl 1): 112-115 PubMed PMID: 20027155 Keywords: Animals, Aorta, Blotting, Western, Calcimycin: ... Journal Article 2008; 29(5): 775-778 PubMed PMID: 18987578 Keywords: Aldehyde Reductase:antagonists & inhibitors, Animals, ...
Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes ... PubMed PMID: 16439147.. *Kimura H, Miyashita H, Suzuki Y, Kobayashi M, Watanabe K, Sonoda H, et al. Distinctive localization ... High temperature antigen retrieval does not work, but protease pretreatment is mandatory.. The protocol was established at the ... PubMed PMID: 11719431.. *Jackson DG. The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1. Trends ...
  • CD44 antigen, the main cell surface receptor for HA. (wikipedia.org)
  • CD44 has been referred to as HCAM (homing cell adhesion molecule), Pgp-1 (phagocytic glycoprotein-1), Hermes antigen, lymphocyte homing receptor, ECM-III, and HUTCH-1. (wikipedia.org)
  • CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). (wikipedia.org)
  • Through binding to their T cell receptor (TCR), cytotoxic T cells recognize their cognate antigen presented on the surface of a target cell by a class I MHC molecule. (miltenyibiotec.com)
  • CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. (sysmex-fcm.jp)
  • 5C.C7/RAG-2 -/- B10.A mice, expressing a T cell antigen receptor specific for a pigeon cytochrome c (PCC) peptide (88-104), DO11.10 BALB/c mice expressing a T cell antigen receptor specific for an ovalbumin peptide, C57BL/6 mice, and IL-2-deficient mice (IL-2 -/- ) backcrossed to 5C.C7 19 times ( 14 ) were obtained from Taconic Farms. (pnas.org)
  • The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. (acris-antibodies.com)
  • Vascular endothelial cell growth factor (VEGF), IL-8, and monocyte chemotactic protein-1 (MCP-1) mRNA and protein levels and expression and small interfering RNA silencing of MIF CD74/CD44 receptor complex and phosphorylation of ERK and p38 MAPKs were evaluated. (unboundmedicine.com)
  • 53. T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice. (imi-muenchen.de)
  • It is a cell-surface receptor that mediates cell-cell and cell-matrix interactions through its affinity for hyaluronic acid (HA) and possibly also through its affinity for other ligands (PMID: 10694938). (ptglab.com)
  • Signaling through the leukocyte function-associated antigen 1 (LFA-1) molecule has previously been shown to induce homotypic aggregation in T cells and to induce cytoskeletal changes in T lymphoma cells. (biomedsearch.com)
  • CD44 is a multistructural and multifunctional cell surface molecule involved in cell proliferation, cell differentiation, cell migration, angiogenesis, presentation of cytokines, chemokines, and growth factors to the corresponding receptors, and docking of proteases at the cell membrane, as well as in signaling for cell survival. (wikipedia.org)
  • High levels of the adhesion molecule CD44 on leukemic cells are essential to generate leukemia. (wikipedia.org)
  • Since the CD44 variant 6(v6) molecule has been noted as a marker for tumor metastasis and prognosis in several tumors, we examined whether or not v6 is a useful marker for evaluating the prognosis of pancreatic cancer patients. (nih.gov)
  • Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. (acris-antibodies.com)
  • However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. (acris-antibodies.com)
  • Interaction of CD44, an adhesion molecule, with its extracellular matrix ligand, hyaluronan (HA), has been suggested to play a critical role in a number of biological manifestations, including cell migration, tumorigenesis, metastasis, and regulation of immune responses. (biologicalworld.com)
  • Breast cancer stem cells have been identified to strongly express adhesion molecule CD44, together with no or very low levels of adhesion molecule CD24. (aacrjournals.org)
  • However, a monoclonal antibody to CD44 induced a similar phenotype in activated lymphocytes. (biomedsearch.com)
  • The rat monoclonal antibody IM7 recognizes CD44 antigen, an 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc. (sysmex-fcm.jp)
  • The antibody reacts with all isoforms of mouse CD44. (sysmex-fcm.jp)
  • A monoclonal antibody against the extracellular domain of mouse and human epithelial V-like antigen 1 reveals a restricted expression pattern among CD4- CD8- thymocytes. (medworm.com)
  • ELISA: Endoglin/CD105 Antibody (3A9) [NBP2-22122] - Red: Control Antigen (100ng), Purple: Antigen (10ng), Green: Antigen (50ng), Blue: Antigen (100ng). (novusbio.com)
  • This antibody recognizes an epitope encoded by exon v3 on the variant portion of human CD44. (ximbio.com)
  • Monoclonal antibodies against CD44 variants include bivatuzumab for v6. (wikipedia.org)
  • The anti-CD11/CD18 monoclonal antibodies (mAbs) submitted in the Second International Workshop on Ruminant Leukocyte Differentiation Antigens, were analysed for their reactivity with the ovine homologue of CD11/CD18. (antibodybeyond.com)
  • CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. (wikipedia.org)
  • Furthermore, because alternative splicing and posttranslational modifications generate many different CD44 sequences, including, perhaps, tumor-specific sequences, the production of anti-CD44 tumor-specific agents may be a realistic therapeutic approach. (wikipedia.org)
  • Reports indicate that high CD44 expression in ascites tumor cells (ATC) correlates with CSC and EMT phenotype, both regulated by the tumor microenvironment through several signaling pathways, including the TGF-beta signaling pathway. (theanimestop.com)
  • Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumor growth and metastasis, antiapoptosis and directional motility of cancer cells. (sysmex-fcm.jp)
  • Authors: Babaer D, Zheng M, Ivy MT, Zent R, Tiriveedhi V Abstract Previous phase I DNA-vaccine based clinical trials using Mammaglobin-A (Mam-A), a human breast tumor associated antigen (TAA), demonstrated that this agent was safe and efficient at treating patients with stage IV breast cancer. (medworm.com)
  • The long-term success of cancer vaccines is limited by the diminished expression of human leukocyte antigen (HLA) class I molecules in the tumor microenvironment. (medworm.com)
  • Suryo Rahmanto Y., Dunn L. L., Richardson D. R. The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis. (wikipedia.org)
  • CD44 variant isoforms are also relevant to the progression of head and neck squamous cell carcinoma. (wikipedia.org)
  • A number of different isoforms of CD44 generated by alternative splicing have been isolated and sequenced. (biologicalworld.com)
  • The CD44 protein is expressed as a family of molecular isoforms generated from alternative RNA splicing and posttranslational modifications. (ximbio.com)
  • Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms. (ximbio.com)
  • The biological functions of CD44, including the regulation of lymphocyte recruitment to the sites of inflammation, have been attributed to the generation of a functionally active, HA-adhesive phenotype. (biologicalworld.com)
  • The molecular mechanisms underlying the regulation of CD44 expression and the generation of a functionally active HA-binding phenotype are not well understood. (biologicalworld.com)
  • CD8(+) T-cell memory phenotype and function are acquired after antigen-driven activation. (nih.gov)
  • Furthermore, we demonstrate that during homeostatic expansion in a suitable environment, naïve phenotype (CD44 low ) OT-I T cells converted to memory phenotype (CD44 med/high ), despite the absence of foreign antigenic stimulation. (pnas.org)
  • We show that this proliferation depends on both expression of appropriate self peptide/MHC ligands and T cell "space" in the periphery and is accompanied by changes in cell-surface phenotype (conversion from CD44 low to CD44 med/high ) indicative of at least partial activation. (pnas.org)
  • The surface membrane antigen phenotype of human blood basophils. (antibodybeyond.com)
  • Red Blood Cell (RBC) and Platelet (PLT) antigen genotype to phenotype correlations. (bloodantigens.com)
  • Experiments in animals have shown that targeting of CD44 by antibodies, antisense oligonucleotides, and CD44-soluble proteins markedly reduces the malignant activities of various neoplasms, stressing the therapeutic potential of anti-CD44 agents. (wikipedia.org)
  • Immunocytochemical analysis of EM-G3 in vitro revealed positivity for keratins (K) K5, K14, K18, nuclear protein p63, epithelial membrane antigen (EMA) and other proteins indicative of a pattern of mammary epithelium bipotent progenitors. (ovid.com)
  • These signs are antigens - processed pieces of proteins from invading microbes - that are displayed on the surface of so-called antigen-presenting cells.Before it encounters its specific antigen, a T cell is called naive. (elifesciences.org)
  • In addition to foreign antigens from microbes, antigen-presenting cells display fragments of the body's own proteins too. (elifesciences.org)
  • 3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix. (duke.edu)
  • Initially described for their carbohydrate-binding activity [ PMID: 14533786 ], they are now recognised as a more diverse group of proteins, some of which are involved in protein-protein, protein-lipid or protein-nucleic acid interactions [ PMID: 12223269 ]. (ebi.ac.uk)
  • Magnetic cell sorting (MACS) is a method of enriching a heterogeneous cell mixture, by means of proteins or cell surface antigens, by MACS that is based on cell passage by magnetic column, or by the separation system (SEP system), in which a tube of labeled cells is placed in a magnetic field, and positive cells are retained in the tube while the negative cells are transfered to the suspension liquid. (scielo.br)
  • Expression of leukocyte differentiation antigens during the differentiation of HL-60 cells induced b. (biomedsearch.com)
  • Ex vivo glycan engineering of the surface of live cells has been used to enforce HCELL expression on any cell that expresses CD44. (wikipedia.org)
  • CD44 expression is an indicative marker for effector-memory T-cells. (wikipedia.org)
  • Endometrial cells in women with endometriosis demonstrate increased expression of splice variants of CD44, and increased adherence to peritoneal cells. (wikipedia.org)
  • In many cancers (renal cancer and non-Hodgkin's lymphomas are exceptions), a high level of CD44 expression is not always associated with an unfavorable outcome. (wikipedia.org)
  • Murine memory cells are CD44 high and low in the expression of activation markers such as CD25 (IL-2R), whereas human memory cells are CD45RA-, CD45RO+. (nih.gov)
  • we demonstrated that miR711mediated downregulation of CD44 expression inhibited EMT of gastric cancer cells in vitro and in vivo by downregulating vimentin protein expression and upregulating Ecadherin protein expression through transfection, qRTPCR and western blotting. (theanimestop.com)
  • Expression levels of MACC1, CD44, Twist1, and KiSS-1 are related to duration of overall survival among patients with colonic adenocarcinoma. (theanimestop.com)
  • The expression of CD44 variants was evaluated immunohistochemically in paraffin-embedded pancreatic cancer tissues from 42 patients who were confirmed surgically and histologically to have received curative resection. (nih.gov)
  • On the other hand, expression of total CD44 (including CD44v, as well as CD44s) was observed in both tumors and adjacent normal sites. (nih.gov)
  • Interestingly, a hallmark feature on the GC B cell surface is the stage-specific expression of a glycan moiety T antigen (TAg), known functionally as a regulator of effector T cell fate. (harvard.edu)
  • Recent advances in the regulation of CD44 expression and its role in inflammation and autoimmune diseases. (biologicalworld.com)
  • This review will focus on the recent advances in the molecular mechanisms regulating CD44 expression, ligand binding, as well as the contribution of CD44 to the development of inflammation and autoimmune disorders. (biologicalworld.com)
  • CD44 glycoproteins in colorectal cancer: expression, function, and prognostic value. (biologicalworld.com)
  • CD44 expression on blood eosinophils is a novel marker of bronchial asthma. (biomedsearch.com)
  • A descriptive statistical analysis of the nonresponder before treatment showed a below-responder range degree of expression for CD4, CD8, CD44 (H-CAM), CD56, CD62L, HLA-DQ, and also for these epitopes in colocation with EfaBS. (mysciencework.com)
  • We confirmed expression of EVA1 on cortical and medullary epithelial cell subsets and revealed a restricted pattern of expression on CD4- CD8- double negative (DN) cell subsets, with the highest level of expression on DN3 (CD44(low)CD25(+)) thymocytes. (medworm.com)
  • The current study assessed the impact of various selenocompounds on the expression of HLA class I molecules in THP-1 cells, an apparent proficient antigen that pres. (medworm.com)
  • Purified naive (CD4+ CD62L+ CD44-) T cells from 10-11 weeks old T cell specific Furin knockout (CD4-cre fur flox/flox) and littermate wild type (fur flox/flox) control mice were profiled for gene expression using Affymetrix MOE 430 2.0 microarray platform. (omicsdi.org)
  • CD24 expression was inversely correlated with multifocality, and CD44 expression was significantly correlated with a BRAF mutation. (cdc.gov)
  • Following determination of surface antigen expression, MSC were loaded into scaffolds in a perfusion bioreactor and loading efficiency was quantified. (unibas.ch)
  • CD44 and Bcl-2 expression was detected in 86% and 82% of breast tumours, respectively. (aacrjournals.org)
  • Although the existence of a set of universal markers for stem cells 4 is in quarrel, the most used in the literature are CD34, CD44, AC133, Keratin15, and gene expression of ABCG2, p63 and BMI1. (scielo.br)
  • Antigen expression: I-A+ Ref Kim KJ, et al. (bolognaunited.it)
  • The pattern of expression of the 5T4 oncofoetal antigen on normal, dysplastic and malignant oral mucosa. (openrepository.com)
  • Over-expression of the gene influences cell adhesion, shape and motility, which may be related to changes in the cellular localisation of the 5T4 oncofoetal antigen as malignancy develops. (openrepository.com)
  • To establish whether the 5T4 oncofoetal antigen can serve as a tumour-specific marker for oral cancer and precancer, we have evaluated the pattern of expression on biopsies of normal, inflamed and dysplastic oral mucosa using immunohistochemistry. (openrepository.com)
  • The alterations in the pattern and intensity of 5T4 oncofoetal antigen expression were not related to clinicopathological features of the tumours examined. (openrepository.com)
  • These data show that the 5T4 oncofoetal antigen is expressed on normal oral mucosa, such that this target cannot be used for detection of neoplastic or preneoplastic cells, although altered expression may contribute to the pathogenesis of these lesions. (openrepository.com)
  • CD44 expression is also upregulated in subpopulations of cancer cells and is recognized as a molecular marker for cancer stem cells (PMID: 29747682). (ptglab.com)
  • In humans, the CD44 antigen is encoded by the CD44 gene on Chromosome 11. (wikipedia.org)
  • CD44 gene transcription is at least in part activated by beta-catenin and Wnt signalling (also linked to tumour development). (wikipedia.org)
  • Kudo J., Chao L.Y., Narni F., Saunders G.F. Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens (англ. (wikipedia.org)
  • Chinese hamster ovary (CHO) fibroblast cell lines expressing the CD11a/CD18 or CD11b/CD18 antigen were engineered by gene transfection. (antibodybeyond.com)
  • C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins [ PMID: 15476922 ]. (ebi.ac.uk)
  • However, unlike the RBC Blood Groups Systems, the HPA Systems were not named on a per gene or related gene basis with one or more antigens in each system. (bloodantigens.com)
  • Rather, one HPA gene can contain multiple HPA systems so in reality each biallelic antithetical antigen pair is really its own system. (bloodantigens.com)
  • For example, the HPA-1 system contains the antithetical antigens HPA-1a and HPA-1b, but this same gene also contains the HPA-4 system (HPA-4a and HPA-4b). (bloodantigens.com)
  • Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3. (wikipedia.org)
  • miR-218-5p was downregulated in invasion front cells and negatively regulates oral squamous cell carcinoma invasiveness by targeting the CD44-ROCK pathway. (theanimestop.com)
  • Recombinant Human CD44 protein ( ab114154 ) can be used as a positive control in WB. (abcam.com)
  • Leukocyte function-associated antigen 1 (LFA-1) and CD44 are signalling molecules for cytoskeleton-dependent morphological changes in activated T cells. (biomedsearch.com)
  • Splice variants of CD44 on colon cancer cells display sialofucosylated HCELL glycoforms that serve as P-, L-, and E-selectin ligands and fibrin, but not fibrinogen, receptors under hemodynamic flow conditions pertinent to the process of cancer metastasis. (wikipedia.org)
  • In addition, variations in CD44 are reported as cell surface markers for some breast and prostate cancer stem cells. (wikipedia.org)
  • Here, we used advanced imaging in mouse models of hepatitis B virus (HBV) pathogenesis to understand the mechanisms whereby these cells home to the liver, recognize antigens, and deploy effector functions. (nih.gov)
  • The requirements for the activation of memory cells for proliferation and cytokine production are not quite as strict as those of naive cells, but costimulation in the broad sense is required for optimum responses and for responses to suboptimum antigen concentrations. (nih.gov)
  • Maturing from thymocytes, T cells undergo several development stages: After selection in the thymus, they circulate the body as naïve T cells, each with a unique antigen-specificity. (miltenyibiotec.com)
  • Upon antigen encounter, they are activated, differentiate into a specific subtype, expand and fulfill their role as effector cells, e.g., by migrating into various tissues and organs. (miltenyibiotec.com)
  • For long-lasting immune memory, some of the antigen-activated T cells differentiate into various memory T cell subtypes. (miltenyibiotec.com)
  • Larkin J, Renukaradhya GJ, Sriram V, Du W, Gervay-Hague J, Brutkiewicz RR: CD44 differentially activates mouse NK T cells and conventional T cells. (sysmex-fcm.jp)
  • There is therefore great interest in developing stable, antigen specific regulatory T cells for treatment of asthma and allergies ( Bassirpour and Zoratti, 2014 ). (elifesciences.org)
  • In particular, the contribution of antigen-specific Tr1 cells to tolerogenic memory is unclear. (elifesciences.org)
  • CD11b/CD18 and CD11c/CD18 are more restricted antigens normally expressed on monocytes, macrophages, PMN and natural killer cells. (antibodybeyond.com)
  • CD11 antigens appeared to be strongly expressed only on mature granulocytes, monocytes, and certain lymphocytes, but not significantly on myeloid committed precursor cells. (antibodybeyond.com)
  • Detection of integrins α-6, β-1, and protein CD44 by cDNA array also pointed to the character of basal/stem cells. (ovid.com)
  • After encountering its antigen, the naive T cell activates and then develops into a variety of immune cells, each with a specific activity. (elifesciences.org)
  • All naive T cells recognize some "Self-antigens", but not as strongly as they recognize foreign antigens. (elifesciences.org)
  • As a naive T cell travels around the body, it repeatedly interacts with antigen-presenting cells that display Self-antigens, which triggers a low level of signaling in the T cell. (elifesciences.org)
  • For example, the naive T cells that respond the most to Self-antigens were seen to be much more likely to become pTreg cells when activated than other T cells. (elifesciences.org)
  • also conclude that contact with antigen-presenting cells causes calcium signals that shape how the T cells behave. (elifesciences.org)
  • a ) Total circulating CD8 + T cells were analysed ex vivo for the frequency of memory CD44 + CD62L + CD8 + T cells, virtual memory CD44 + CD49d lo CD8 + T cells (VM) and true memory CD44 + CD49d hi CD8 + T cells (TM) in WT and IFNAR −/− mice. (nih.gov)
  • c ) Naive CD44 − CD8 + T cells and CD44 + CD62L + memory CD8 + T cells were sorted and cultured for the indicated time with or without rIFNβ (100 U ml −1 ). (nih.gov)
  • Once T cell maturation is complete, however, it has been assumed that such reactivity toward self is lost (inherent in the idea of self tolerance) and that the TCR played no significant role in the survival of resting naïve T cells, before encounter with foreign antigen. (pnas.org)
  • These studies showed that naïve CD8 T cells survived for long periods of time in the presence of cognate self MHC molecules (i.e., in that case, H-2D b ) and persisted as resting cells in the absence of stimulatory antigen. (pnas.org)
  • Dendritic cells (DCs) are the most potent antigen-presenting cells playing a pivotal role in the induction of the immune response ( 1 )( 2 )( 3 ). (rupress.org)
  • These results show for the first time that MIF exerts a potent indirect angiogenic effect by interacting with ectopic endometrial cells and inducing the secretion of major angiogenic factors via CD44, CD74, and MAPK signaling pathways and provide evidence for a possible new mechanism underlying endometriosis development and pathophysiology. (unboundmedicine.com)
  • These cells were positive for CD44, a marker that has been suggested to be expressed on breast cancer stem cells. (openrepository.com)
  • In culture, a subpopulation (3 +/- 1%) of slowly dividing, CD44+ cells gave rise to rapidly dividing, CD44- cells. (openrepository.com)
  • CD4+CD62L+CD44- naive, CD4+CD62L-CD44+ memory and CD4+CD25+FoxP3+ regulatory T cells were isolated from Fur flox/flox and CD4 cre Fur flox/flox mice. (omicsdi.org)
  • Antigen emergence rapidly stimulates T cells, which leads to changes in cytokine production, cell proliferation, and differentiation. (omicsdi.org)
  • Experiment Overall Design: Naive CD4+ CD62L+ CD44- T cells were isolated from Fur flox/flox and CD4 cre Fur flox/flox mice. (omicsdi.org)
  • detects a surface antigen expressed on basophils and their CD34(+) precursor cells, as well as the basophil cell line KU-812, is identical to the ectonucleotide pyrophosphatase / phosphodiesterase 3 (E-NPP3). (antibodybeyond.com)
  • Videira PA, Silva M, Martin KC, Sackstein R. Ligation of the CD44 Glycoform HCELL on Culture-Expanded Human Monocyte-Derived Dendritic Cells Programs Transendothelial Migration. (harvard.edu)
  • CD44, VEGF and MMP-2 were consistently expressed in endometriotic epithelial and stromal cells. (unboundmedicine.com)
  • In this study, Becattini et al examine whether individual pathogens (including a fungus, bacteria and a vaccine) instigate one predominant subtype of human CD4 + helper cells and whether a single antigen specific clone can differentiate to multiple subtypes. (focisnet.org)
  • CD44 exerts a functional role during EMT induction in cisplatin-resistant head and neck cancer cells. (mbl.co.jp)
  • 57. Activated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion. (imi-muenchen.de)
  • Autoreactive B cells, maturated coincidentally, normally do not receive survival signals by antigen planted on follicular dendritic cells and perish by apoptosis. (livehopelupus.org)
  • CD44 is a type I transmembrane glycoprotein expressed on embryonic stem cells and in various levels on other cell types including connective tissues and bone marrow. (ptglab.com)
  • 1X10^6 human peripheral blood lymphocytes were surface stained with 10 ul FITC-Anti-Human CD44 (FITC-65063, clone F10-44-2) (red) or 10 ul FITC-mouse IgG2a isotype control (blue). (ptglab.com)
  • The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. (wikipedia.org)
  • CD44 is an integral cell membrane glycoprotein that binds to hyaluronan and is involved in matrix adhesion, lymphocyte activation, and lymph node homing. (ximbio.com)
  • We show that circulating CD8 TE arrest within liver sinusoids by docking onto platelets previously adhered to sinusoidal hyaluronan via CD44. (nih.gov)
  • Link domain, which includes the Link module of TSG-6 [ PMID: 12972412 ] (a hyaladherin with important roles in inflammation and ovulation) and the hyaluronan binding domain of CD44 (which contains extra N-terminal beta-strand and C-terminal beta-hairpin) [ PMID: 14992719 ]. (ebi.ac.uk)
  • Most T cell subtypes can undergo several differentiation steps after activation by their respective antigen. (miltenyibiotec.com)
  • This result is in accordance with the increase of activated CD4(+)CD44(high)CD62L(low) T lymphocytes observed in spleen of BPA-exposed rats compared to controls. (nih.gov)
  • Dr. Telen is recognized as an expert in the biochemistry and molecular genetics of blood group antigens and the pathophysiological mechanisms of vaso-occlusion in sickle cell disease. (duke.edu)
  • One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). (wikipedia.org)
  • Katoh S, Matsumoto N, Kawakita K, Tominaga A, Kincade PW, Matsukura S: A role for CD44 in an antigen‑induced murine model of pulmonary eosinophilia. (sysmex-fcm.jp)
  • Initial studies have taken advantage of anti-CD44 antibodies which specifically block CD44-HA interactions. (biologicalworld.com)
  • Notably, injection of IFN-treated HIV-1-pulsed DCs in SCID mice reconstituted with autologous PBLs resulted in the generation of a potent primary immune response, as evaluated by the detection of human antibodies to various HIV-1 antigens. (rupress.org)
  • Immunohistochemical staining was performed with antibodies for CD44, VEGF, MMP-2 and Ki-67. (unboundmedicine.com)
  • Si-Tahar M, Sitaraman S, Shibahara T, Madara JL: Negative regulation of epithelium‑neutrophil interactions via activation of CD44. (sysmex-fcm.jp)
  • Recently, CD44-HA interactions have been reported to play a critical role in a number of autoimmune diseases in humans and experimental animal models. (biologicalworld.com)
  • propose that the continuous interactions with Self-antigens trigger waves of calcium ions in a naive T cell that shapes its behavior and future development. (elifesciences.org)
  • CD44 is expressed on multiple cell types and is involved in multiple functions including cell-cell interactions and cell-extracellular matrix binding. (ximbio.com)
  • 2016. Proc Natl Acad Sci U S A. :. PMID: 27872288. (ximbio.com)
  • Mouse reactivity reported in scientific literature (PMID: 27322553). (novusbio.com)
  • FITC-65063 targets CD44 in FC applications and shows reactivity with Human samples. (ptglab.com)
  • CD11a/CD18 is a lymphocyte function-associated antigen-1, and CD11b/CD18 is a macrophage antigen-1. (antibodybeyond.com)
  • macrophages were SWC3+SWC9+CD14low, the latter also displaying a down-regulation of CD11a/18, and, to a lesser degree, CD44. (eurekamag.com)
  • Carcinoembryonic Antigen as a Marker for Colorectal Cancer: Is It Clinically Useful? (wikipedia.org)
  • In addition, the generation of CD44-deficient animals has facilitated our understanding of the involvement of CD44 in inflammation and autoimmune diseases. (biologicalworld.com)
  • CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. (sysmex-fcm.jp)
  • CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. (ptglab.com)
  • Supplementary MaterialsBone marrow derived MSCs were positive for CD44, CD73, CD166, and CD105 and bad for CD14, CD45, CD34, and CD31 as shown by flow cytometry analysis (Number S1). (bolognaunited.it)
  • In this report, we demonstrate that 9.3- lymphocytes express CD11, an antigen which is also present on monocytes and granulocytes. (antibodybeyond.com)
  • Hegde VL, Singh NP, Nagarkatti PS, Nagarkatti M: CD44 mobilization in allogeneic dendritic cell‑T cell immunological synapse plays a key role in T cell activation. (sysmex-fcm.jp)
  • CD44 comprises a large family of transmembrane glycoproteins that exhibit extensive molecular heterogeneity. (biologicalworld.com)
  • The work identified two new host factors that may act as receptors for P. falciparum during invasion: CD44 and CD55. (theanimestop.com)
  • Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in cell adhesion. (wikipedia.org)
  • CD44 is expressed in a large number of mammalian cell types. (wikipedia.org)
  • CD44, along with CD25, is used to track early T cell development in the thymus. (wikipedia.org)
  • Successful recognition of an antigen then leads to killing of the target cell. (miltenyibiotec.com)
  • To this end, we have discovered that glycosyltransferase, GCNT2, which catalyzes the synthesis of I-antigen (or I-branched glycans), is a critical negative regulator of Gal-3- and Gal-9-binding activity that profoundly influences B cell immunity and melanoma progression. (harvard.edu)
  • Legg JW, Lewis CA, Parsons M, Ng T, Isacke CM: A novel PKC‑regulated mechanism controls CD44 ezrin association and directional cell motility. (sysmex-fcm.jp)
  • McKallip RJ, Do Y, Fisher MT, Robertson JL, Nagarkatti PS, Nagarkatti M: Role of CD44 in activation‑induced cell death: CD44‑deficient mice exhibit enhanced T cell response to conventional and superantigens. (sysmex-fcm.jp)
  • Although it is present in over 90% of T-cell lymphomas , it is generally less effective at demonstrating this condition than is CD3 antigen. (wikidoc.org)
  • Most cell types express CD44 but do not bind HA. (biologicalworld.com)
  • Prognostic value of putative cancer stem cell markers (CD24, CD44, CD133, and ALDH1) in human papillary thyroid carcinoma. (cdc.gov)
  • Automated Typing of Red Blood Cell and Platelet Antigens: a Whole-genome Sequencing Study. (bloodantigens.com)
  • On the contrary, in some neoplasms CD44 upregulation is associated with a favorable outcome. (wikipedia.org)
  • However, this antigen is strongly expressed by many cancers and tumour-associated labelling correlates with metastatic spread and poor clinical outcome for patients with gastric and colon cancer. (openrepository.com)
  • Garratt R. C., Jhotí H. A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function. (wikipedia.org)
  • Claesson L., Larhammar D., Rask L., Peterson P.A. cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure (англ. (wikipedia.org)
  • Synthetic peptide within Human CD44 aa 150-250. (abcam.com)
  • Similar to RBC Blood Group antigen the Human Platelet Antigen (HPAs) are each defined by antigen specific alloantibody sera. (bloodantigens.com)
  • Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence. (wikipedia.org)
  • In situ localization of melanotransferrin (melanoma-associated antigen P97) in human liver. (wikipedia.org)
  • Chromosomal sublocalization of the human p97 melanoma antigen. (wikipedia.org)
  • The human 5T4 oncofoetal antigen is expressed by all types of trophoblast in pregnancy but is not detected on most adult tissues, although low levels are found on some epithelia. (openrepository.com)
  • Hepatocellular antigen recognition triggers effector functions in a diapedesis-independent manner and is inhibited by the processes of sinusoidal defenestration and capillarization that characterize liver fibrosis. (nih.gov)
  • Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. (abcam.com)
  • High temperature antigen retrieval does not work, but protease pretreatment is mandatory. (acris-antibodies.com)
  • Therefore, CD24 and CD44 are related to clinicopathological aggressive features and important for determining surgical extent in patients with PTC. (cdc.gov)
  • In humans, the carcinoembryonic antigen family consists of 29 genes, 18 of which are normally expressed. (wikipedia.org)