The number of PLATELETS per unit volume in a sample of venous BLOOD.
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.
The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.
A subnormal level of BLOOD PLATELETS.
The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other "foreign" surfaces.
The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.
Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.
Increased numbers of platelets in the peripheral blood. (Dorland, 27th ed)
The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
Laboratory examination used to monitor and evaluate platelet function in a patient's blood.
Very large BONE MARROW CELLS which release mature BLOOD PLATELETS.
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.
Duration of blood flow after skin puncture. This test is used as a measure of capillary and platelet function.
A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.
A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow MEGAKARYOCYTES and their release of blood platelets. The process is called THROMBOPOIESIS.
Any form of purpura in which the PLATELET COUNT is decreased. Many forms are thought to be caused by immunological mechanisms.
An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.
Human alloantigens expressed only on platelets, specifically on platelet membrane glycoproteins. These platelet-specific antigens are immunogenic and can result in pathological reactions to transfusion therapy.
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
The process of generating thrombocytes (BLOOD PLATELETS) from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via the MEGAKARYOCYTES. The humoral factor with thrombopoiesis-stimulating activity is designated THROMBOPOIETIN.
Surgical procedure involving either partial or entire removal of the spleen.
Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Formation and development of a thrombus or blood clot in the blood vessel.
Cell adhesion molecule and CD antigen that mediates the adhesion of neutrophils and monocytes to activated platelets and endothelial cells.
The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.
The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.
The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.
A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
A clinical syndrome characterized by repeated spontaneous hemorrhages and a remarkable increase in the number of circulating platelets.
Bleeding or escape of blood from a vessel.
A syndrome of HEMOLYSIS, elevated liver ENZYMES, and low blood platelets count (THROMBOCYTOPENIA). HELLP syndrome is observed in pregnant women with PRE-ECLAMPSIA or ECLAMPSIA who also exhibit LIVER damage and abnormalities in BLOOD COAGULATION.
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.
Cell surface receptors that are specific for THROMBOPOIETIN. They signal through interaction with JANUS KINASES such as JANUS KINASE 2.
Platelet membrane glycoprotein IIb is an integrin alpha subunit that heterodimerizes with INTEGRIN BETA3 to form PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX. It is synthesized as a single polypeptide chain which is then postranslationally cleaved and processed into two disulfide-linked subunits of approximately 18 and 110 kDa in size.
Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.
Tests used in the analysis of the hemic system.
Elements of limited time intervals, contributing to particular results or situations.
Laboratory tests for evaluating the individual's clotting mechanism.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).
The preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor.
The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.
A phospholipid from the platelet membrane that contributes to the blood clotting cascade by forming a phospholipid-protein complex (THROMBOPLASTIN) which serves as a cofactor with FACTOR VIIA to activate FACTOR X in the extrinsic pathway of BLOOD COAGULATION.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
A subspecialty of internal medicine concerned with morphology, physiology, and pathology of the blood and blood-forming tissues.
Endogenous substances, usually proteins, that are involved in the blood coagulation process.
The co-occurrence of pregnancy and a blood disease (HEMATOLOGIC DISEASES) which involves BLOOD CELLS or COAGULATION FACTORS. The hematologic disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Disorder characterized by a decrease or lack of platelet dense bodies in which the releasable pool of adenine nucleotides and 5HT are normally stored.
A preparation consisting of PLATELETS concentrated in a limited volume of PLASMA. This is used in various surgical tissue regeneration procedures where the GROWTH FACTORS in the platelets enhance wound healing and regeneration.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Use of a thrombelastograph, which provides a continuous graphic record of the physical shape of a clot during fibrin formation and subsequent lysis.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A condition in newborns caused by immunity of the mother to PLATELET ALLOANTIGENS on the fetal platelets. The PLATELETS, coated with maternal ANTIBODIES, are destroyed and removed by the fetal MONONUCLEAR PHAGOCYTE SYSTEM. Affected infants may have INTRACRANIAL HEMORRHAGES.
An antibiotic mixture of two components, A and B, obtained from Nocardia lurida (or the same substance produced by any other means). It is no longer used clinically because of its toxicity. It causes platelet agglutination and blood coagulation and is used to assay those functions in vitro.
The number of RETICULOCYTES per unit volume of BLOOD. The values are expressed as a percentage of the ERYTHROCYTE COUNT or in the form of an index ("corrected reticulocyte index"), which attempts to account for the number of circulating erythrocytes.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).
Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Proteins prepared by recombinant DNA technology.
A subclass of purinergic P2Y receptors that have a preference for ADP binding and are coupled to GTP-BINDING PROTEIN ALPHA SUBUNIT, GI. The P2Y12 purinergic receptors are found in PLATELETS where they play an important role regulating PLATELET ACTIVATION.
Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
Antibodies produced by a single clone of cells.
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
Agents that prevent clotting.
The number of LYMPHOCYTES per unit volume of BLOOD.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and impaired or absent clot retraction. Platelet membranes are deficient in or have a defect in the glycoprotein IIb-IIIa complex (PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX).
A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
A familial coagulation disorder characterized by a prolonged bleeding time, unusually large platelets, and impaired prothrombin consumption.
A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.
A transient increase in the number of leukocytes in a body fluid.
A measure of the size of PLATELETS.
Condensed areas of cellular material that may be bounded by a membrane.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The natural enzymatic dissolution of FIBRIN.
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.
An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
Disorders caused by abnormalities in platelet count or function.
Soluble protein fragments formed by the proteolytic action of plasmin on fibrin or fibrinogen. FDP and their complexes profoundly impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinolysis.
A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Disorders of the blood and blood forming tissues.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Physiologically active compounds found in many organs of the body. They are formed in vivo from the prostaglandin endoperoxides and cause platelet aggregation, contraction of arteries, and other biological effects. Thromboxanes are important mediators of the actions of polyunsaturated fatty acids transformed by cyclooxygenase.
Group of hemorrhagic disorders in which the VON WILLEBRAND FACTOR is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion.
Enlargement of the spleen.
A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Synthetic compounds that are analogs of the naturally occurring prostaglandin endoperoxides and that mimic their pharmacologic and physiologic activities. They are usually more stable than the naturally occurring compounds.
The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.
A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
The rate dynamics in chemical or physical systems.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
A count of SPERM in the ejaculum, expressed as number per milliliter.
The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
Disease having a short and relatively severe course.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The preparation of leukocyte concentrates with the return of red cells and leukocyte-poor plasma to the donor.
A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
Pathological processes involving the integrity of blood circulation. Hemostasis depends on the integrity of BLOOD VESSELS, blood fluidity, and BLOOD COAGULATION. Majority of the hemostatic disorders are caused by disruption of the normal interaction between the VASCULAR ENDOTHELIUM, the plasma proteins (including BLOOD COAGULATION FACTORS), and PLATELETS.
Diversion of blood flow through a circuit located outside the body but continuous with the bodily circulation.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE.
Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
Transplantation of an individual's own tissue from one site to another site.
Dilated blood vessels in the ESOPHAGUS or GASTRIC FUNDUS that shunt blood from the portal circulation (PORTAL SYSTEM) to the systemic venous circulation. Often they are observed in individuals with portal hypertension (HYPERTENSION, PORTAL).
A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.
An encapsulated lymphatic organ through which venous blood filters.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
A calcium-activated enzyme that catalyzes the hydrolysis of ATP to yield AMP and orthophosphate. It can also act on ADP and other nucleoside triphosphates and diphosphates. EC
A lymphohematopoietic cytokine that plays a role in regulating the proliferation of ERYTHROID PRECURSOR CELLS. It induces maturation of MEGAKARYOCYTES which results in increased production of BLOOD PLATELETS. Interleukin-11 was also initially described as an inhibitor of ADIPOGENESIS of cultured preadipocytes.
A metallic element, atomic number 49, atomic weight 114.82, symbol In. It is named from its blue line in the spectrum. (From Dorland, 28th ed)
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Therapy with two or more separate preparations given for a combined effect.
A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
A decrease in the number of NEUTROPHILS found in the blood.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.
The cells found in the body fluid circulating throughout the CARDIOVASCULAR SYSTEM.
Onset of HYPERREFLEXIA; SEIZURES; or COMA in a previously diagnosed pre-eclamptic patient (PRE-ECLAMPSIA).
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI.
Cell surface proteins that bind THROMBOXANES with high affinity and trigger intracellular changes influencing the behavior of cells. Some thromboxane receptors act via the inositol phosphate and diacylglycerol second messenger systems.
The quantity of volume or surface area of CELLS.
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
Drugs that act on blood and blood-forming organs and those that affect the hemostatic system.
Agents that cause clotting.
The parent cells that give rise to cells in the MEGAKARYOCYTE lineage, and ultimately BLOOD PLATELETS.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The deformation and flow behavior of BLOOD and its elements i.e., PLASMA; ERYTHROCYTES; WHITE BLOOD CELLS; and BLOOD PLATELETS.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
ERYTHROCYTE size and HEMOGLOBIN content or concentration, usually derived from ERYTHROCYTE COUNT; BLOOD hemoglobin concentration; and HEMATOCRIT. The indices include the mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC).
The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.
Progenitor cells from which all blood cells derive.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Any procedure in which blood is withdrawn from a donor, a portion is separated and retained and the remainder is returned to the donor.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
An infant during the first month after birth.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
The degree of replication of the chromosome set in the karyotype.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC
Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC; and HEMOLYTIC-UREMIC SYNDROME. Multiple etiological factors include VASCULAR ENDOTHELIAL CELL damage due to SHIGA TOXIN; FACTOR H deficiency; and aberrant VON WILLEBRAND FACTOR formation.
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
A rare, inherited platelet disorder characterized by a selective deficiency in the number and contents of platelet alpha-granules. It is associated with THROMBOCYTOPENIA, enlarged platelets, and prolonged bleeding time.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.

Fractionated administration of irinotecan and cisplatin for treatment of lung cancer: a phase I study. (1/2217)

A combination chemotherapy of irinotecan (CPT-11) and cisplatin (CDDP) has been reported to be active for lung cancer. In the previous trial, however, diarrhoea and leucopenia became the major obstacle for sufficient dose escalation of CPT-11 to improve the treatment outcome. We conducted a phase I study to investigate whether the fractionated administration of CDDP and CPT-11 at escalated dose was feasible and could improve the treatment outcome. Twenty-four previously untreated patients with unresectable non-small-cell lung cancer (NSCLC) or extensive disease of small-cell lung cancer (SCLC) were eligible. Both CDDP and CPT-11 were given on days 1 and 8, and repeated every 4 weeks. The dose of CDDP was fixed at 60 mg m(-2) and given by 1-h infusion before CPT-11 administration. The starting dose of CPT-11 was 40 mg m(-2), and the dose was escalated by an increase of 10 mg m(-2). The maximally tolerated dose of CPT-11 was determined as 60 mg m(-2) because grade 4 haematological or grade 3 or 4 non-haematological toxicities developed in six patients out of 11 patients evaluated. Diarrhoea became a dose-limiting toxicity. The objective response rates were 76% for NSCLC and 100% for SCLC. The recommended dose of CPT-11 and CDDP in a phase II study will be 50 mg m(-2) and 60 mg m(-2) respectively.  (+info)

Bronchoconstrictor effect of thrombin and thrombin receptor activating peptide in guinea-pigs in vivo. (2/2217)

1. Several thrombin cellular effects are dependent upon stimulation of proteinase activated receptor-1 (PAR-1) localized over the cellular surface. Following activation by thrombin, a new N-terminus peptide is unmasked on PAR-1 receptor, which functions as a tethered ligand for the receptor itself. Synthetic peptides called thrombin receptor activating peptides (TRAPs), corresponding to the N-terminus residue unmasked, reproduce several thrombin cellular effects, but are devoid of catalytic activity. We have evaluated the bronchial response to intravenous administration of human alpha-thrombin or a thrombin receptor activating peptide (TRAP-9) in anaesthetized, artificially ventilated guinea-pigs. 2. Intravenous injection of thrombin (100 microkg(-1)) caused bronchoconstriction that was recapitulated by injection of TRAP-9 (1 mg kg(-1)). Animal pretreatment with the thrombin inhibitor Hirulog (10 mg kg(-1) i.v.) prevented thrombin-induced bronchoconstriction, but did not affect bronchoconstriction induced by TRAP-9. Both agents did not induce bronchoconstriction when injected intravenously to rats. 3. The bronchoconstrictor effect of thrombin and TRAP-9 was subjected to tolerance; however, in animals desensitized to thrombin effect, TRAP-9 was still capable of inducing bronchoconstriction, but not vice versa. 4. Depleting animals of circulating platelets prevented bronchoconstriction induced by both thrombin and TRAP-9. 5. Bronchoconstriction was paralleled by a biphasic change in arterial blood pressure, characterized by a hypotensive phase followed by a hypertensive phase. Thrombin-induced hypotension was not subject to tolerance and was inhibited by Hirulog; conversely, hypertension was subject to tolerance and was not inhibited by Hirulog. Hypotension and hypertension induced by TRAP-9 were neither subject to tolerance nor inhibited by Hirulog. 6. Our results indicate that thrombin causes bronchoconstriction in guinea-pigs through a mechanism that requires proteolytic activation of its receptor and the exposure of the tethered ligand peptide. Platelet activation might be triggered by the thrombin effect.  (+info)

Primary percutaneous transluminal coronary angioplasty performed for acute myocardial infarction in a patient with idiopathic thrombocytopenic purpura. (3/2217)

A 72-year-old female with idiopathic thrombocytopenic purpura (ITP) complained of severe chest pain. Electrocardiography showed ST-segment depression and negative T wave in I, aVL and V4-6. Following a diagnosis of acute myocardial infarction (AMI), urgent coronary angiography revealed 99% organic stenosis with delayed flow in the proximal segment and 50% in the middle segment of the left anterior descending artery (LAD). Subsequently, percutaneous transluminal coronary angioplasty (PTCA) for the stenosis in the proximal LAD was performed. In the coronary care unit, her blood pressure dropped. Hematomas around the puncture sites were observed and the platelet count was 28,000/mm3. After transfusion, electrocardiography revealed ST-segment elevation in I, aVL and V1-6. Urgent recatheterization disclosed total occlusion in the middle segment of the LAD. Subsequently, PTCA was performed successfully. Then, intravenous immunoglobulin increased the platelet count and the bleeding tendency disappeared. A case of AMI with ITP is rare. The present case suggests that primary PTCA can be a useful therapeutic strategy, but careful attention must be paid to hemostasis and to managing the platelet count.  (+info)

Antithrombotic efficacy of thrombin inhibitor L-374,087: intravenous activity in a primate model of venous thrombus extension and oral activity in a canine model of primary venous and coronary artery thrombosis. (4/2217)

The small molecule direct thrombin inhibitor L-374,087 was characterized across species in an in vitro activated partial thromboplastin clotting time (aPTT) assay and in vivo in rhesus monkey and dog thrombosis models. In vitro in rhesus, dog, and human plasma, L-374,087 concentrations eliciting 2-fold increases in aPTT were 0.25, 1.9, and 0.28 microM, respectively. In anesthetized rhesus monkeys, 300 microgram/kg bolus plus 12 microgram/kg/min and 300 microgram/kg bolus plus 30 microgram/kg/min L-374,087 i.v. infusions significantly reduced jugular vein thrombus extension, with both regimens limiting venous thrombus extension to 2-fold that of baseline thrombus mass compared with a 5-fold extension observed in the vehicle control group. Antithrombotic efficacy in the rhesus with the lower-dose regimen was achieved with 2.3- to 2.4-fold increases in aPTT and prothrombin time. In a conscious instrumented dog model of electrolytic vessel injury, the oral administration of two 10 mg/kg L-374,087 doses 12 h apart significantly reduced jugular vein thrombus mass, reduced the incidence of and delayed time to occlusive coronary artery thrombosis, and significantly reduced coronary artery thrombus mass and ensuing posterolateral myocardial infarct size. Antithrombotic efficacy in the dog was achieved with 1.6- to 2.0-fold increases in aPTT at 1 to 6 h after oral dosing with L-374,087. These results indicate significant antithrombotic efficacy against both venous and coronary arterial thrombosis with L-374,087 with only moderate elevations in aPTT or prothrombin time. The oral efficacy of L-374,087 characterizes this compound as a prototype for the further development of orally active direct thrombin inhibitors.  (+info)

Prospective randomized multicenter study comparing cyclosporin alone versus the combination of antithymocyte globulin and cyclosporin for treatment of patients with nonsevere aplastic anemia: a report from the European Blood and Marrow Transplant (EBMT) Severe Aplastic Anaemia Working Party. (5/2217)

We report the results of the first prospective randomized multicenter study of immunosuppressive treatment in patients with previously untreated nonsevere aplastic anemia (AA) as defined by a neutrophil count of at least 0.5 x 10(9)/L and transfusion dependence. Patients were randomized to receive cyclosporin (CSA) alone or the combination of horse antithymocyte globulin ([ATG] Lymphoglobuline; Merieux, Lyon, France) and CSA. The endpoint of the study was the hematologic response at 6 months. One hundred fifteen patients were randomized and assessable with a median follow-up period of 36 months; 61 received CSA and 54 ATG and CSA. In the CSA group, the percentage of complete and partial responders was 23% and 23%, respectively, for an overall response rate of 46%. A significantly higher overall response rate of 74% was found in the ATG and CSA group, with 57% complete and 17% partial responders (P =. 02). Compared with CSA alone, the combination of ATG and CSA resulted in a significantly higher median hemoglobin level and platelet count at 6 months. Fewer patients required a second course of treatment before 6 months due to a nonresponse. In the CSA group, 15 of 61 (25%) patients required a course of ATG before 6 months because of disease progression, compared with only 3 of 54 (6%) in the ATG and CSA group. The survival probabilities for the two groups were comparable, 93% (CSA group) and 91% (ATG and CSA group), but at 180 days, the prevalence of patients surviving free of transfusions, which excluded patients requiring second treatment because of nonresponse, death, disease progression, or relapse, was 67% in the CSA group and 90% in the ATG and CSA group (P =.001). We conclude that the combination of ATG and CSA is superior to CSA alone in terms of the hematologic response, the quality of response, and early mortality, and a second course of immunosuppression is less frequently required.  (+info)

Thrombopoietin: its role from early hematopoiesis to platelet production. (6/2217)

BACKGROUND AND OBJECTIVE: Thrombopoietin (TPO), also referred to as MpI ligand, is the most potent cytokine that physiologically regulates platelet production. With the availability of sufficient amounts of recombinant forms of the protein, the biological in vitro and in vivo activities of this cytokine have been extensively studied. The objective of this review is to summarize the published data focusing on TPO production and regulation and to discuss the pleiotropic biological action of this hormone. The review also highlights the results so far obtained in preclinical and clinical trials. EVIDENCE AND INFORMATION SOURCES: The material examined in this review includes data published by the author and articles or abstracts published in Journals covered by Medline. The author has contributed to the isolation of TPO, has been working in the field for several years and has contributed original papers on the TPO/MpI system in normal and pathologic situations. STATE OF THE ART: TPO is a hormone constitutively produced by the liver and kidneys. Plasma levels of TPO are regulated through receptor-mediated uptake, internalization and catabolism. First thought to be a lineage dominant factor promoting megakaryocytopoiesis, several lines of evidence indicate that TPO has pleiotropic effects on hematopoiesis. In vitro studies show that TPO alone, or in combination with early acting cytokines, stimulates the proliferation and enhances the expansion of primitive CD34+ CD38- hematopoietic progenitor cells. In vivo studies with c-mpl- and TPO-null mice reveal that the molecule sustains the survival and proliferation of early committed progenitor cells of various type. Preclinical and clinical trials indicate that recombinant TPO molecules increase platelet counts and megakaryocyte numbers in normal or mildly thrombocytopenic states. However, no significant effects of TPO administration on platelet recovery have so far been reported in patients subjected to intensive chemotherapy regimens. Recombinant molecules appear to be safe to administer and very little toxicity is reported. TPO augments the number of erythroid and myeloid committed progenitor cells in marrow, and mobilized stem cells in peripheral blood. PERSPECTIVES: The potential clinical use of TPO is still unclear. With the increased knowledge of the multiple effects of TPO on hematopoiesis, it is expected that future carefully monitored clinical trials will provide more information regarding the eventual benefits of this cytokine in the treatment of thrombocytopenia. At present, one successful application of TPO appears to be its addition in cytokine cocktails used to expand hematopoietic stem cells ex vivo.  (+info)

Patients with thrombocytosis have normal or slightly elevated thrombopoietin levels. (7/2217)

BACKGROUND AND OBJECTIVE: The distinction between clonal and reactive thrombocytoses is a frequent problem and implies different therapeutic options. As thrombopoietin (TPO) is the main regulator of megakaryocytopoiesis and thrombopoiesis, we measured TPO levels in patients with thrombocytosis in an attempt to understand the regulation and potential utility of distinguishing thrombocytoses. DESIGN AND METHODS: Serum TPO levels, platelet counts, mean platelet volume, hemoglobin, erythrocyte sedimentation rate and age were evaluated in 25 patients with clonal thrombocytosis (15 with essential thrombocythemia, 6 with polycythemia vera and 4 with chronic myeloid leukemia) and in 50 patients with reactive thrombocytosis distributed in three groups: 1) patients in post-surgical states; 2) patients with solid tumors; and 3) patients with inflammatory diseases. RESULTS: TPO levels were slightly increased in patients with clonal (135+/-50 pg/mL) and reactive (147+/-58 pg/mL) thrombocytosis compared with controls (121+/-58 pg/mL). Analyzing the different groups, patients with essential thrombocythemia had the lowest TPO levels (120+/-28 pg/mL) and patients with solid tumors the highest levels (162+/-59 pg/mL). Patients with clonal thrombocytosis were older, had higher platelet counts, mean platelet volume and hemoglobin, and lower erythrocyte sedimentation rate than patients with reactive thrombocytosis. INTERPRETATION AND CONCLUSIONS: Minor differences were observed in TPO levels between patients with primary and secondary thrombocytoses. Erythrocyte sedimentation rate, but not TPO levels, may be a useful tool for discriminating both types of thrombocytoses.  (+info)

Neutrophil activation and hemostatic changes in healthy donors receiving granulocyte colony-stimulating factor. (8/2217)

Granulocyte colony-stimulating factor (G-CSF) enhances neutrophil functions in vitro and in vivo. It is known that neutrophil-derived products can alter the hemostatic balance. To understand whether polymorphonuclear leukocyte (PMN) activation, measured as PMN degranulation and phenotypical change, may be associated to hemostatic alterations in vivo, we have studied the effect of recombinant human G-CSF (rHuG-CSF) administration on leukocyte parameters and hemostatic variables in healthy donors of hematopoietic progenitor cells (HPCs). Twenty-six consecutive healthy donors receiving 10 micrograms/kg/d rHuG-CSF subcutaneously for 5 to 7 days to mobilize HPCs for allogeneic transplants were included in the study. All of them responded to rHuG-CSF with a significant white blood cell count increase. Blood samples were drawn before therapy on days 2 and 5 and 1 week after stopping rHuG-CSF treatment. The following parameters were evaluated: (1) PMN activation parameters, ie, surface CD11b/CD18 antigen expression, plasma elastase antigen levels and cellular elastase activity; (2) plasma markers of endothelium activation, ie, thrombomodulin (TM) and von Willebrand factor (vWF) antigens; (3) plasma markers of blood coagulation activation, ie, F1+2, TAT complex, D-dimer; and (4) mononuclear cell (MNC) procoagulant activity (PCA) expression. The results show that, after starting rHuG-CSF, an in vivo PMN activation occurred, as demonstrated by the significant increment of surface CD11b/CD18 and plasma elastase antigen levels. Moreover, PMN cellular elastase activity, which was significantly increased at 1 day of treatment, returned to baseline at day 5 to 6, in correspondence with the elastase antigen peak in the circulation. This change was accompanied by a parallel significant increase in plasma levels of the two endothelial and the three coagulation markers. The PCA generated in vitro by unstimulated MNC isolated from rHuG-CSF-treated subjects was not different from that of control cells from untreated subjects. However, endotoxin-stimulated MNC isolated from on-treatment individuals produced significantly more PCA compared with both baseline and control samples. All of the parameters were decreased or normal 1 week after stopping treatment. These data show that rHuG-CSF induces PMN activation and transiently affects some hemostatic variables in healthy HPC donor subjects. The clinical significance of these findings remains to be established.  (+info)

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TY - JOUR. T1 - Effect of graded exercise on platelet count, adhesion and aggregation. AU - Arao, T.. AU - Ikuyama, T.. AU - Osanai, H.. PY - 1979. Y1 - 1979. N2 - It is generally accepted that platelet is one of the important factors in blood coagulability, and many studies have reported that short strenuous exercise would increase platelet count and function. However, we have been unable to find any studies on such changes during the course of graded exercise. In the present study, therefore, we investigated the changes in platelet count and function during three different graded exercise on a bicycle ergometer.. AB - It is generally accepted that platelet is one of the important factors in blood coagulability, and many studies have reported that short strenuous exercise would increase platelet count and function. However, we have been unable to find any studies on such changes during the course of graded exercise. In the present study, therefore, we investigated the changes in platelet count ...
The platelet count of a healthy person would range from 150,000 to 450,000 per microliter. If your platelet count goes lower than 150,000, you could have thrombocytopenia. You could experience excessive bleeding on the nose and gums, fatigue, prolonged bleeding of cuts, as well as bruising in different parts of your body. Low platelet count can be caused by some certain medical issues. If you are experiencing any of the following, you might want to check out this take on how to get your platelet count back to normal and talk to your doctor about it. Medical conditions that can cause low platelet count:. Bacterial Infections In Blood Bacteria can contaminate the blood and would damage the different blood cells, affecting how they develop and function. When you have an infection in the blood, you would need to get immediate medical attention. Consult your doctor about medication or treatment you can take to address the issue. Dengue Fever The dengue virus is carried by mosquitoes and is ...
title:Role of Platelet Parameters in Diagnosing Various Clinical Conditions. Author:Amar R. Shah, Sanjay N. Chaudhari, Menka H. Shah. Keywords:Platelet count, Mean Platelet Volume, Platelet Distribution Width, Clinical conditions. Type:Original Article. Abstract:Background: With improvement in the technologies, advancement occurs in all field including medicine. Automated cell counters are widely used for diagnosis of different diseases. Hematocrits are important parameters that are used in routine practices. Now a day for analysing platelet abnormalities, plateletcrits are utilized. Among them Platelet counts, mean platelet volume (MPV) and platelet distribution width (PDW) are important parameters. Aims and objective: To study platelet parameters in various clinical conditions. Materials and Methods: A cross sectional observational study was carried out at one of the rural teaching hospitals of Gujarat. Laboratory Data from 800 patients were analysed using Microsoft excel. Result: Total 800 ...
While these food groups are essential to help you combat instances of having platelet count low in number, its better to start on a diet with the help of your general practitioner or nutritionist, more importantly if you dont carry any guide with you. This is also important in order to specifically understand - what does a low platelet count mean - in your case and what thrombocytopenia treatment option is the most appropriate. Many people often disregard the occurrence of food allergies when they change their diet. Be careful, especially with regards to doubtful approaches. Food allergies can have severe side effects such as depression, constant fatigue and even cell destruction. In this event, allergic reactions caused by diet changes might actually lead to the destruction of healthy blood cells instead of the purpose of helping with regeneration of the same.. VIEW MEDICAL TREATMENT METHODS TO INCREASE PLATELET COUNT. Getting to understand what is low platelet count is not enough. Learn ...
I have a |b|low blood platelet count for the past 2 years. The count is less than 20,000|/b|. I suffer from fatigue and occasional pain on the sides of my tongue. My RBC and WBC count is in the normal range, but my haemoglobin count is low. I also suffer from Proctosigmoiditis for the past 10 years. What can be done to bring the platelet count to normal?
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A high platelet count, also known as thrombocytosis, indicates the existence of an increase in the amount of thrombocytes or platelets in the blood. It is a component of the blood that helps with blood clotting in response to injury. An increase in platelet count is not an unusual occurrence in young children. A normal platelet level ranges … Continue reading 10 Causes of High Platelet Count in Children. ...
Low white cell count and low platelet count causes, Overview. Thrombocytopenia is a condition in which you have a low blood platelet count. Platelets (thrombocytes) are colorless blood cells that. - at a glance monthly desk pad calendar 2018
In patients with thrombocytopenia, it can be difficult to predict a patients bleeding risk based on platelet count alone. Platelet reactivity may provide additional information; however, current clinical assays cannot reliably assess platelet function in the setting of thrombocytopenia. New methods to study platelet reactivity in thrombocytopenic samples are needed. In this study, we sought to develop a laboratory model of thrombocytopenia using blood from healthy subjects that preserves the whole blood environment and reproducibly produces samples with a specific platelet count and hematocrit. We compared the activation state of unstimulated and agonist-stimulated platelets in thrombocytopenic samples derived from this method with normocytic controls. Whole blood was diluted with autologous red blood cell concentrate and platelet-poor plasma, which were obtained via centrifugation, in specific ratios to attain a final sample with a predetermined platelet count and hematocrit. P-selectin exposure and
What Discussion about plateletsThrombocytopenia, platelet count, normal platelet count, high platelet count, low platelets, and other aspect
Platelet Count-A platelet count is a type of lab test that measures the number of platelets in your blood. Know normal range, causes of high and low count
Thrombocytopenia is one of many blood disorders where there is a low count of the platelet. According to the medical description, the blood consists of 150,000 to 450,000 of platelets/micro-liter, anything that is high or below the range is considered abnormal; but what does a normal platelet count do? This article aims to uncover how normal platelet count is important to the human body. What is platelet? Healthy platelets.. Read More. ...
Thrombocytopenia is one of many blood disorders where there is a low count of the platelet. According to the medical description, the blood consists of 150,000 to 450,000 of platelets/micro-liter, anything that is high or below the range is considered abnormal; but what does a normal platelet count do? This article aims to uncover how normal platelet count is important to the human body. What is platelet? Healthy platelets.. Read More. ...
Platelets are an important blood component that helps in controlling bleeding. The most abundant particle in our blood is the platelet that causes the blood to clot whenever theres a cut or injury, thereby stopping the bleeding in minutes. Now, there are tens and thousands of platelets in normal which help in this process. But in cases of certain diseases and illness like dengue etc the platelets gets destroyed by the infective germ, making the body prone to bleeding. Such a low count of platelet can cause serious brain damage and other organ damage. Apart from a blood transfusion, the most trusted way to increase your platelet count is by eating low platelets treatment food. Foods to increase platelet count are often used as basic preventive care and home remedy for diseases like dengue. But how do these home remedies to increase platelets work is a very basic understanding of…. ...
The normal platelet count for adult males is 150 to 450 billion per liter of blood, notes Mayo Clinic. Platelet counts outside of this range may be indicative of a medical condition or be the result...
A low platelet count can cause various disorders in the body. It can also be fatal if this problem is not treated immediately. It is, therefore, essential to do
The Online Health Advice to Thrombocytopenia What stops your blood to clot? Learn everything you need to know more about Thrombocytopenia. Introduction to Low Platelets Count If you ride a bicycle down the street and accidentally ran over a nail, the result will be a flat tire. These small tears ...
Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease characterized by the presence of platelet autoantibodies, low platelet counts and an increased risk of bleeding. TPO receptor agonists which stimulate platelet production have been shown to be remarkably effective in ITP. Their use as a short-term means of elevating platelet counts in preparation for surgical procedures has not yet been adequately evaluated.. Many patients with moderate to severe ITP (platelet count less than 50 x 10exp9/L) have stable platelet counts and do not bleed; however, when surgeries or invasive procedures become necessary, additional treatment is often required to increase the platelet count to achieve adequate hemostasis. Although specific guidelines for surgical platelet count thresholds in ITP are lacking, platelet transfusion guidelines recommend a platelet count of 50 - 100 x10exp9/L for the vast majority of surgical procedure; 50x10exp9/L is a typical threshold for minor surgeries like tooth ...
Learn everything you need to know about low platelet counts, causes, and symptoms. Living with the disease is easier when you know how to properly manage it.
A low blood platelet count, known as thrombocytopenia, prevents blood from clotting normally. This can be an indication of serious medical conditions.SignificanceThe three main reasons for a low blood platelet count include reduced platelet production at bone marrow, blockage of platelets at enlarged spleen and an overuse or elimination of platelets by the body.Conditions Affecting Bone MarrowHIV and cancers such as leukemia and lymphoma reduce the capacity of bone marrow to produce platelets.Conditions Affecting the SpleenMyelofibrosis and certain forms of cirrhosis can enlarge the spleen. This hinders the passage of platelets into the bl...
Thrombocytopenia: Thrombocytopenia refers to low platelet count. The platelet count is usually less than 150,000 cells per microliter. Low platelet count in patients with acute myeloid leukemia is typically due to two reasons. Firstly, leukemic cell infiltration in the bone marrow results in disruption of normal megakaryocyte production with decreased platelet production. Secondly, coagulopathy (disseminated intravascular coagulation) can result in platelet consumption and therefore a low platelet count. This latter reason is unique to the acute promyelocytic leukemia category of acute myeloid leukemia. The degree of thrombocytopenia also confers prognostic value in acute promyelocytic leukemia: platelet counts lower than 40,000 cells per microliter carries a worse prognosis than platelet counts greater than 40,000 cells per microliter.[1] ...
Wondering about how to boost platelet count fast and naturally? Herere the 12 best platelet boosting foods to increase the platelet count and levels easily.
Participants received ruxolitinib orally twice a day. The starting dose was based on Baseline platelet count. Patients with Baseline platelet count , 200,000/μL began a dose regimen of 20 mg twice daily. Patients with Baseline platelet count of 100,000/μL to 200,000/μL (inclusive) began a dose regimen of 15 mg twice daily. The dose was adjusted by the Investigator based on efficacy and safety to a maximum of 25 mg twice daily. Patients receiving benefit could continue treatment until the later of marketing approval or when the last randomized patient remaining in the study had completed Week 144 (36 months ...
Overview of the platelet count, used to screen for, diagnose, and monitor conditions that affect the number of platelets in the blood
Read Cancer incidence in patients with a high normal platelet count: a cohort study using primary care data, Family Practice on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Elevated platelet counts can occur for a number of reasons. Platelets are an acute phase reactant, which means the number goes up in the face of any inflammation (such as with a cold or illness). In severe cases, the platelet count can reach the millions. (That is, 1,000. The numbers are indicative of thousands so your count is actually 579,000 platelets ...
A low platelet count can cause mild to very serious health complications. But, dont worry! Nature has a solution for every problem.
How low can your platelets get before it becomes dangerous? I know that normal platelet counts are between 150,000 and 420,000. My grandmother has lupus and her doctors have differing opinions on how l...
Rheumatoid Arthritis And Low Blood Platelets Count- thrombocytopenia the term for low blood platelets if you suffer from thrombocytopenia,you lack required platelets in your blood.
Mucosal healing (MH) has been indicated as the therapeutic goal for ulcerative colitis (UC). Platelet count is known as an inflammation evaluation. However, the association between platelet count and MH among patients with UC is still scarce. We therefore assessed this issue among Japanese patients with UC. The study subjects consisted of 345 Japanese patients with UC. Platelet count was divided into quartiles on the basis of the distribution of all study subjects (low, moderate, high, and very high). Several endoscope specialists were responsible for evaluating MH and partial MH, which was defined as a Mayo endoscopic subscore of 0 and 0-1, respectively. Estimations of crude odds ratios (ORs) and their 95% confidence intervals (CIs) for partial MH and MH in relation to platelet count were performed using logistic regression analysis. Age, sex, CRP, steroid use, and anti-Tumor necrosis factor α (TNFα) preparation were selected a priori as potential confounding factors. The percentage of partial MH and
Question - Suffering from amoebaiasis, decreasing platelet count. How to improve platelet count?. Ask a Doctor about when and why Platelet count is advised, Ask a Hematologist
Hi all, Im fairly new to these forums. I lost my son Jasper in March of 2009. I have been activly ttc his brother or sister since Sept with no luck. I was just wondering because Im very nervous about this because my platelet counts are on the lower side of normal and was wondering if anyone else has this problem? I did talk to my OB and he said it should be fine, but still very very worried. Just for reference purposes Im at 184 and normal is 150 - ...
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ITP occurs when immune system cells produce antibodies against platelets. The antibodies attach to the platelets. Read this post for more information.
Materials and Methods: This cross-sectional study involved 100 Type-2 diabetic patients attending the Diabetology Outpatient Department of SRM Medical College Hospital and Research Centre aged between 30 and 60 years and 100 age-matched non-diabetic subjects as controls. Subjects with acute illness, those on antiplatelet medications and smokers were excluded. After history taking and clinical examination, glycosylated hemoglobin (HbA1c), fasting and postprandial blood glucose levels, platelet parameters such as platelet count, platelet distribution width (PDW), MPV, platelet-large cell ratio, and plateletcrit were determined ...
Aim: We aimed to compare platelet counts (Plt), plateletcrit (PCT) and platelet distribution width (PDW) values of type 1 diabetes mellitus (T1DM) patients with those of healthy subjects. Methods: The records of 39 T1DM ...
I have just the results of blood and can not appear before my doc next few weeks, and if only a few bright minds at Yahoo, which could help me! I am suffering from severe pain, burning, swollen joints, back, hands, feet, knees, Im controlling exycontin40mg 2x daily pain. I asked the doc, the ED, D-me for arthritis and rheumatoid arthritis blood tests - everything normal except the platelet count (408) and the rate of sedimentation in the first 44 hours after 76 hours. Thank you guys for your help! ...
Brief Answer: improving B12 levels Detailed Answer: Hello, If you improve your vitamin B12 levels by the shots and sublingual B12 you are taking then hopefully your platelet counts will improve to normal. There are other things that can cause platelet abnormalities so once your vitamin B12 is...
1] Henry JB: Clinical Diagnosis and Management by Laboratory Methods, 20th ed. Saunders, 2001. [2] Wang C, Smith BR, Ault KA, et al: Reticulated platelets predict platelet count recovery following chemotherapy. Transfusion 2002; 42(3):368-374. [3] Kurata Y, Hayashi S, Kiyoi T, et al: Diagnostic value of tests for reticulated platelets, plasma glycocalicin, and thrombopoietin levels for discriminating between hyperdestructive and hypoplastic thrombocytopenia. Am J Clin Pathol 2001; 115(5):656-664. [4] Peterec SM, Brennan SA, Rinder HM, et al: Reticulated platelet values in normal and thrombocytopenic neonates. J Pediatr 1996; 129(2):269-274. [5] Goldstein KH: Efficient diagnosis of thrombocytopenia.. Am Fam Physician 1996; 53:915-919. [6] Richards EM & Baglin TP: Quantitation of reticulated platelets: methodology and clinical application. Br J Haematol 1995; 91(2):445-451. [7] Rutherford CJ & Frenkel EP: Thrombocytopenia: issues in diagnosis and therapy.. Med Clin N Am 1994; 78:555-575. [8] ...
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Platelet function in our body part is essential for the process of blood coagulation. A normal platelet count is 150,000 to 450,000 but different diseases can cause levels fall can cause internal bleeding. A low platelet count is a serious matter that requires medical supervision, but in your diet you could find extra help. In here we give you a list of foods to increase plateletsand improve your health. ...
Dr. Ho responded: How high?. There are different causes of high platelet level. Generally is divided by 2- primary bone marrow problem vs secondary causes/ reactive process ( such as: bleeding, |a href=/topics/iron track_data={
TPO-RAs could be theoretically useful in IT patients in two clinical contexts. Short-term treatment courses could be used to transiently increase platelet count in preparation for elective surgery or invasive procedures. Moreover, patients at high risk of spontaneous bleeding may benefit from long-term administration. Results obtained so far are promising in that they indicate that TPO-RAs may be effective, but experience in this field is still limited.. In a small clinical trial, 12 consecutive patients with MYH9-RD and platelet counts lower than 50 × 109/L were treated with eltrombopag for 3-6 weeks. Eleven patients responded, and 8 of them achieved major responses (platelet count higher than 100 × 109/L or three times the baseline value). Treatment was well tolerated and bleeding diathesis disappeared in 8 of 10 patients with spontaneous bleeding at baseline [10]. Based on these results, one patient with MYH9-RD and ,20 × 109 platelets/L received eltrombopag for preparation to a major ...
The first person is an elderly woman, in the infusion center to get platelets. Normal platelet count is 150-400 and you can walk around with a platelet count of 80 and in general be ok. Her platelet count was six. At 15 they give you a platelet transfusion. So she is basically a train wreck waiting to happen. Brain bleeds, internal organ leakage - nasty stuff. You really need platelets to do what youd like to do - like walk around without having your organs bleed internally. So youd expect this woman to be super stressed, or terrified or something. But no. She just walks in (carefully, because if you bruise yourself when your platelet count is six, you are some kind of fucked.) Sits in the chair, gets hooked up, calm as can be and sucks up the life giving platelets. And oh yeah, she has an incurable blood disease and will be dead in six months. And her daughter is with her, bemoaning how the universe can allow someone to hit and run her car while shes transporting her dying mother to the ...
Differential diagnosis of thrombocytosis is not always obvious. The routine clinical chemistry laboratory classically provides only limited help in distinguishing between reactive thrombocytosis (RT) and autonomous thrombocytosis, where platelet production escapes normal regulatory processes, and which is seen in myeloproliferative diseases (MPD) such as essential thrombocythemia and polycythemia vera. We explored the clinical use of platelet distribution width (PDW) in the differential diagnosis of thrombocytosis. During a 3-month period, 250 patients presenting with a platelet count , 500 x 10(9)/L were studied; 174 were classified as having RT, 42 had a diagnosis of MPD, and 34 patients were excluded because they had a hemopathy different from MPD, and either did or did not present a known etiologic factor for RT. First, we determined that in the RT group the value of PDW was closely linked to both mean platelet volume (MPV) and platelet count (PLT) (PDW = 79.5-0.005 PLT -3.5 MPV; r = 0.848, ...
DU PLESSIS, L.. Blood platelet counts, morphology and morphometry in lions, Panthera leo. Onderstepoort j. vet. res. [online]. 2009, vol.76, n.3, pp.317-321. ISSN 2219-0635.. Due to logistical problems in obtaining sufficient blood samples from apparently healthy animals in the wild in order to establish normal haematological reference values, only limited information regarding the blood platelet count and morphology of free-living lions (Panthera leo) is available. This study provides information on platelet counts and describes their morphology with particular reference to size in two normal, healthy and free-ranging lion populations. Blood samples were collected from a total of 16 lions. Platelet counts, determined manually, ranged between 218 and 358 x 109/l. Light microscopy showed mostly activated platelets of various sizes with prominent granules. At the ultrastructural level the platelets revealed typical mammalian platelet morphology. However, morphometric analysis revealed a ...
SOUZA, AM et al. Platelet indices in dogs with thrombocytopenia and dogs with normal platelet counts. Arch. med. vet. [online]. 2016, vol.48, n.3, pp.277-281. ISSN 0301-732X. It is well known that thrombocytopenia is the most commonly acquired haemostatic disorder in dogs and can be potentially life-threatening. With the use of automated analysers, platelet indices such as Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), and Platelet Large Cell Ratio (P-LCR), became routinely available, allowing data comparison and error checks which results in a more effective quality control. The aim of this study was to evaluate the pattern of platelet indices (MPV, PDW and P-LCR) in dogs with thrombocytopenia and with normal platelet values. The results of 351 CBCs processed in an automated veterinary haematology counter Sysmex® pocH-100iV Diff were analysed. Two groups of dogs were established, those with thrombocytopenia (45) and those with ...
Material and Methods: A total of 160 cases with cirrhosis due to any cause were included in this study. The study included both male and female subjects and was restricted to age 35-70 years. Exclusion criteria were also applied to this group of patients. All these patients underwent blood test for platelet count and ultrasound abdomen for splenic diameter. For each patient calculation of platelet/splenic ratio was determined with a cut off value of 909 determined. Values greater than this cut off were supposed not to have high risk esophageal varices. Upper gastrointestinal endoscopies were performed on all patients and then on the basis of endoscopy results the patients were divided into two groups, first group in which high risk EVs (grade 2 and grade 3) were present and second group in which they were absent. Subsequently sensitivity, specificity, predictive values and accuracy were calculated, keeping in view the calculated cut off value and endoscopy findings ...
CLINICAL QUESTION: What is the optimal platelet count threshold for prophylactic platelet transfusions to minimize bleeding, platelet use, and adverse clinical outcomes in thrombocytopenic patients with hematological malignant neoplasms? BOTTOM LINE: Maintaining a higher platelet count threshold (≤20 × 109/L or ≤30 × 109/L) was not associated with less bleeding than the current standard (≤10 × 109/L), but required more platelet transfusions (low-quality evidence).
TY - JOUR. T1 - Comparison of Circulating Endothelial Cell/Platelet Count Ratio to Aspartate Transaminase/Platelet Ratio Index for Identifying Patients with Cirrhosis. AU - Sethi, Saurabh. AU - Simonetto, Douglas. AU - Abdelmoneim, Soha S.. AU - Campion, Michael B.. AU - Kaloiani, Irakli. AU - Clayton, Amy C.. AU - Kremers, Walter K. AU - Halling, Kevin C.. AU - Kamath, Patrick Sequeira. AU - Talwalkar, Jayant. AU - Shah, Vijay. PY - 2012. Y1 - 2012. N2 - Background/Objectives: Circulating endothelial cells (CECs) are indicative of vascular injury and correlate with severity of vascular diseases. A pilot study showed that the ratio of CEC to platelet count (CEC/PC) was effective in predicting cirrhosis. Therefore, we evaluated CEC/PC in a larger cohort of patients, correlated it with cirrhosis, and compared its operating characteristics with previously described biomarker for cirrhosis, the AST/platelet ratio index (APRI). Methods: Fifty-three patients with cirrhosis, 20 matched healthy ...
An elevated platelet count can be primary or secondary. Primary thrombocytosis is called essential thrombocytosis. It is a form of myeloproliferative disease. However, platelets are also an acute phase reactant. This means that their number increases in states of stress. This is called reactive thrombocytosis. Trauma is definitely stressful. A deep vein thrombosis is also stressful. But was is the expected amount of thrombocytosis in major trauma? Is it 10%? 20%? Is 950,000 highly unlikely? There is no study that examined this specifically, but such high numbers are seen not infrequently.. Thrombosis with thrombocytosis occurs especially with essential thrombocytosis. Most of the thrombotic events are arterial, however venous thrombosis is possible. Thrombosis with reactive thrombocytosis has been described, but it is unlikely, especially with relatively low platelet counts.. When encountering thrombocytosis in the acute setting, the first step is to see if the patient had thrombocytosis before. ...
Platelet activation and consumption are common in critically ill patients and are associated with poorer prognosis. Mean platelet volume is a simple surrogate for platelet activation, with higher MPV being associated with worse clinical condition on a large array of clinical diagnoses. We therefore aimed to investigate associations between changes in platelet count and mean platelet volume (MPV) with prognosis and inflammatory cytokine values in critically ill patients. This study prospectively included 84 critically ill patients. Patients were stratified into four groups according to proportional changes in MPV (ΔMPV24h) and platelet count (ΔPlat24h) in the first 24 hours after admission. Mortality between groups was compared using the χ2 test. Logistic regression was performed using hospital mortality as outcome and Simplified Acute Physiology Score (SAPS 3), ΔPlat24h and ΔMPV24h as covariates. Concentrations of the following inflammatory mediators were measured using Miliplex® technology: IL1β
The lungs contribute in the final maturation of the circulating platelets, and some studies suggested that chronic lung disease (CLD) could impair circulating platelets maturation or count. Our aim was to study the validity of platelet count (PLT), mean platelet volume (MPV), and plateletcrit (PCT) as simple tools to assess chronic lung disease severity or predict its course. In 39 pediatric patients with CLD, we showed a significant rise in PLTs and PCT and a significant lower MPV when compared to normal controls (P values 0.003, 0.010, 0.004, respectively). Also, a significant positive correlation was detected between the C reactive protein (CRP) level and both the PLTs and PCT (r 0.327, 0.363 respectively) in addition to a significant reduction in MPV level in relation to the age of disease onset (P value 0.031). This study disagrees with the postulation that chronic lung disease could lead to the reduction of circulating platelets and emphasizes the role of increased platelets count and decreased
When should you be concerned about a low platelet count and what causes a lot platelet count? Learn more about how a low platelet count affects your health at
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Mean platelet volume (MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems. MPV is higher when there is destruction of platelets. This may be seen in inflammatory bowel disease, immune thrombocytopenic purpura (ITP), myeloproliferative diseases and Bernard-Soulier syndrome. It may also be related to pre-eclampsia, and recovery from, transient hypoplasia. Abnormally low MPV values correlate with thrombocytopenia when it is due to impaired production as in aplastic anemia. In addition, low MPV can correlate with abnormally small platelet size, sometimes a symptom of a spectrum referred to as Wiskott-Aldrich Syndrome (WAS), caused by a genetic mutation of the WAS gene. A typical ...
In a prospective trial, the immediate and long-term haematological effects of amrinone were studied in sixteen patients with refractory cardiac failure. The platelet count was significantly and variably reduced in all patients and the reduction was related to log plasma amrinone concentration. Platelet survival was significantly reduced in those cases studied. No evidence of disseminated intravascular coagulation or intravascular platelet deposition was observed and the reduced platelet survival was not considered to be the result of an immunological process. Evidence of a marrow response to the reduced platelet count and survival was seen. Although no haemorrhagic symptoms were observed in the patients, the haematological side-effects were considered to be of such severity as to limit the use of this drug in clinical practice ...
Dengue fever symptoms include skin rashes and severe fatigue. A proven remedy is papaya leaf extracts, which increase platelet count, in those affected by this viral illness. Learn more, about dengue fever causes, indications and treatment.
These disorders can cause the spleen to become enlarged. Its considerably a significant low blood platelets treatment approach that helps combat the tendency of the body to confuse and attack its own, including the platelets. The aim will be to improve the immune system to promote an increase in platelet production. While these food groups are essential to help you combat instances of having platelet count low in number, its better to start on a diet with the help of your general practitioner or nutritionist, more importantly if you dont carry any guide with you. Treatment for low platelets will likely be costly but there are several helpful resources that can show you comprehensive specifics and step-by-step guidelines around increasing low platelet count using proven and all natural methods, worth to mention the premium guide Conquer Low Platelets. During this procedure, whole blood is taken from the patient and the plasma is replaced. Although medical science - Foods like beetroots and ...
TY - JOUR. T1 - Interim analysis of safety and efficacy of ruxolitinib in patients with myelofibrosis and low platelet counts. AU - Talpaz, Moshe. AU - Paquette, Ronald. AU - Afrin, Lawrence. AU - Hamburg, Solomon I.. AU - Prchal, Josef T.. AU - Jamieson, Katarzyna. AU - Terebelo, Howard R.. AU - Ortega, Gregory L.. AU - Lyons, Roger M.. AU - Tiu, Ramon V.. AU - Winton, Elliott F.. AU - Natrajan, Kavita. AU - Odenike, Olatoyosi. AU - Claxton, David. AU - Peng, Wei. AU - ONeill, Peter. AU - Erickson-Viitanen, Susan. AU - Leopold, Lance. AU - Sandor, Victor. AU - Levy, Richard S.. AU - Kantarjian, Hagop M.. AU - Verstovsek, Srdan. PY - 2013/10/31. Y1 - 2013/10/31. N2 - Background: Ruxolitinib, a Janus kinase 1 and 2 inhibitor, demonstrated improvements in spleen volume, symptoms, and survival over placebo and best available therapy in intermediate-2 or high-risk myelofibrosis patients with baseline platelet counts ≥100 × 109/L in phase III studies. The most common adverse events were ...
A low platelet count, or thrombocytopenia, can range from mild to severe, depending on the cause. Some people may experience severe bleeding, while others may not have any symptoms. Typically, a low platelet count is the result of a medical condition, such as leukemia, or certain drugs. Learn about treatment options.
Low Platelet Count / Thrombocytopenia:Low Platelet Count is also known as ThrombocytopeniaPlatelets prevent unwanted bleeding by plugging themselves at the site of ...
Low platelet count high mpv - Hypothetical question. A low platelet count (around 10) can be dangerous and needs to be addressed but is it known to make bruising much more likely? Yes. Yes.....bruising, bleeding will be increased.
Looking for medication to treat low+platelet+count+and+bleeding+from+immune+response? Find a list of current medications, their possible side effects, dosage, and efficacy when used to treat or reduce the symptoms of low+platelet+count+and+bleeding+from+immune+response
A low platelet count increases the risk of bleeding and is a side effect of some cancer treatments. Learn about symptoms and treating a low platelet count.
A low platelet count increases the risk of bleeding and is a side effect of some cancer treatments. Learn about symptoms and treating a low platelet count.
During thrombopoiesis, maturing megakaryocytes (MKs) migrate within the complex bone marrow stromal microenvironment from the proliferative osteoblastic niche to the capillary-rich vascular niche where proplatelet formation and platelet release occurs. This physiologic process involves proliferation, differentiation, migration, and maturation of MKs before platelet production occurs. In this study, we report a role for the glycoprotein PECAM-1 in thrombopoiesis. We show that following induced thrombocytopenia, recovery of the peripheral platelet count is impaired in PECAM-1-deficient mice. Whereas MK maturation, proplatelet formation, and platelet production under in vitro conditions were unaffected, we identified a migration defect in PECAM-1-deficient MKs in response to a gradient of stromal cell-derived factor 1 (SDF1), a major chemokine regulating MK migration within the bone marrow. This defect could be explained by defective PECAM-1(-/-) MK polarization of the SDF1 receptor CXCR4 and an increase
TY - JOUR. T1 - Effect of lysed platelet count in platelet concentrates on various growth factor levels after freeze thaw cycles. AU - Nugraha, Yudhi. AU - Sari, Pudji. AU - Purwoko, Reza Yuridian. AU - Luviah, Evah. AU - Adiwinata, Jeanne. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Platelet concentrate (PC) has been used as substitute to the use of fetal bovine serum (FBS) in cell culture media. However, its use as additive in cell culture media showed inconsistent results on cell proliferation, and the inconsistent results may be due to variability of platelet counts or growth factor content. Standard protocols are lacking for the preparation of PC before it is applied as additive in cell culture media. The growth factor content of PC can be released by freeze-thaw cycles, which range from one to three cycles before use for cell culture media. This study aimed to measure base-line platelet counts and growth factor levels and compare to platelet counts and growth factor levels after one, two and three ...
Answer (1 of 3): Low platelet count is known as thrombocytopenia. Symptoms of thrombocytopenia include excessive bleeding, bruising that is caused easily, and bleeding that is caused easily. Platelets are responsible for making a persons blood clot. This occurs when the platelets stick together and stick against the wall of the vessel or capillary. Platelet count can be affected by a persons race or environmental conditions. There are different conditions that can cause low platelet counts. Inherited diseases such as Benard Soulier syndrome or May Hegglin anomaly can cause low platelet counts resulting in heavy bleeding in even small skin lesions. Some people have low platelet count because their body does not produce enough platelets naturally. This can be due to some types of cancer (such as bone marrow cancers,) alcoholism, viral infections, inherited disorders, vitamin B12 deficiency, folic acid deficiency, osteoporosis or myelofibrosis. Some people acquire thrombocytopenia through platelets being
The relationship between platelet count and outcome in patients with acute venous thromboembolism (VTE) has not been consistently explored. RIETE is an ongoing registry of consecutive patients with acute VTE. We categorised patients as having very low- (
Endoscopic detection of esophageal varices [EV] especially the high risk esophageal varices [HREV] is recommended in cirrhotic patients. There are several studies about non-invasive markers to predict the presence of EV. The aim of this study was to evaluate platelet count to spleen diameter [P/D] ratio and platelet count to spleen area [P/A] ratio as predictors for EV and HREV in patients with liver cirrhosis. This prospective study included 100 cirrhotic patients without previous variceal hemorrhage or endoscopic intervesion. Biochemical, imaging and endoscopic findings were collected in all patients. Several parameters including P/D and P/A ratio were measured and their association with the presence of EV and HREV was tested. The results showed that only P/D and P/A ratios were found to be independent predictors for the presence of EV and HREV in multivariant analysis. For prediction of the EV formation in cirrhotic patients, P/D ratio at value
A low platelet count might sound like a pretty scary thing, and in reality, if the condition is severe enough, it can indeed be quite dangerous. The platelets
One interesting report was an update about the drug romiplostin (Nplate®) which has been FDA-approved for patients with idiopathic thrombocytopenic purpura (ITP). Patients with ITP have a low platelet count, not because of a bone marrow problem, but due to an autoimmune problem in which the immune system is attacking the platelets. This drug had been earlier studied in patients with MDS who also have a low platelet count and in the largest study, it was found that romiplostin did improve platelet counts in about 40 to 50% of MDS patients with low platelet counts. This is good news, since we now have a drug that works for platelets in the way that growth factors like erythropoietin (Procrit®) or darbepoetin (Aranesp®) work for low red blood cell counts. Romiplostin can be considered a platelet growth factor, also called a thrombopoietic growth factor (TPO). The problem was that while the randomized Phase 2 study was in progress, the data safety and monitoring board noticed that the patients ...
Doctor: Hello.Thank you for writing to us.Thrombocytopenia is defined as a low platelet count. Regardless of the cause thr ombocytopenia occurs if your platelet count goes below 150,000 per ml. Some Doctors consider thrombocytopenia when levels reach less than 50,000 per ml.Talk to your Doctor to reach the cause. Then, you can work to correct it.Hope this helps. All the best.. ...
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In the ADAPT-1 and ADAPT-2 studies, adults with thrombocytopenia and CLD (n = 231 and n = 204, respectively) were in 1 of 2 cohorts according to their baseline platelet count (below 40 × 109/L or 40 to below 50 × 109/L) and within each cohort were randomized (2:1) to receive 5 daily doses of avatrombopag (60 mg if baseline platelet count below 40 × 109/L or 40 mg if 40 to below 50 × 109/L) or placebo. ADAPT-1 was conducted at 75 study sites in 20 countries, from February 2014 through January 2017, and ADAPT-2 was conducted at 74 sites in 16 countries, from December 2013 through January 2017. The primary endpoint was the proportion of patients not requiring platelet transfusions or rescue procedures for bleeding up to 7 days after a scheduled procedure.. ...
Background Thrombocytosis (raised platelet count) is an emerging risk marker of cancer, but the association has not been fully explored in a primary care context.. Aim To examine the incidence of cancer in a cohort of patients with thrombocytosis, to determine how clinically useful this risk marker could be in predicting an underlying malignancy.. Design and setting A prospective cohort study using Clinical Practice Research Datalink data from 2000 to 2013.. Method The 1-year incidence of cancer was compared between two cohorts: 40 000 patients aged â?¥40 years with a platelet count of ,400 Ã- 109/L (thrombocytosis) and 10 000 matched patients with a normal platelet count. Sub-analyses examined the risk with change in platelet count, sex, age, and different cancer sites.. Results A total of 1098 out of 9435 males with thrombocytosis were diagnosed with cancer (11.6%; 95% confidence interval [CI] = 11.0 to 12.3), compared with 106 of 2599 males without thrombocytosis (4.1%; 95% CI = 3.4 to ...
Persons with leukemia are sometimes treated by replacing cancerous blood cells with early forms of normal blood cells taken from healthy persons. This process is called stem-cell transplantation. Chronic graft-versus-host disease (GVHD) is a common complication of stem-cell transplantation in which the transplanted cells attack the patients own tissues. Antibodies, which are made in a type of cell called B cells, are substances that normally help the body to fight off infection and get rid of foreign substances. When antibodies are directed against the bodys own cells, they are called autoantibodies. Chronic GVHD is thought to interfere with the regulation of the transplanted B cells so that they start to make the autoantibodies that damage body tissues. One possible consequence of chronic GVHD is a low platelet count (thrombocytopenia). Platelets are tiny cells in the bloodstream that are important in blood clotting, and patients with thrombocytopenia are therefore at risk for bleeding. ...
Two years ago, I felt some pain in the lymph glands under my jaw. The sonogram showed that my nodes were insignificantly reactive. My doctor told me to have a reqular blood test and it turned out that I had a low platelet count as well (80,000). Ive had a lot of tests since then and the number is going down every time! Its 45000 now. Almost all the results are normal except for platelets and some protein called Beta 2 microglobulin. My B2M was 2.17 mg/L in the first test, 9 months ago. After 6 months it increased to 2.23, and now its about 2.3. I asked my doctor if the result of B2M was important amd he answered No! Saying its not that high, and that they consider it when it, for example, doubles! One more thing that was not in its normal reference range when I first had the test was CMV IgG (126 and a few days later 230). My doctor has asked me to have another test in three months to see what will happen to the platelets, and said if it gets worse Im gonna have to go through a bone ...
Overview of Low Platelet Count (Thrombocytopenia) - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical Consumer Version.
Objective: Light blood cell (WBC) count to mean platelet volume (MPV) percentage (WMR) is associated with major adverse cardiovascular events in patients with non-ST elevation acute coronary syndrome (NSTEMI). the tertiles. Results: WMR was significantly higher in the CCNG2 patient group compared to the control group (p 0,001). WMR among low, intermediate and high score tertiles were determined to be 89026, 1090042 and 150065, respectively (p 0,001). In receiver operating characteristics (ROC) analysis, WMR 960 3-Hydroxydodecanoic acid expected a SYNTAX score 23 with 80.6% level of sensitivity and 67.6% specificity (AUC: 0.756; 95% CI: 0.685 - 0.818; p 0.0001) and a WMR 1360 predicted a SYNTAX score 33 with 71.4% level of sensitivity and 93% specificity (AUC: 0.840; 95%CI: 0.777 - 0.892; p 0.0001). Conclusions: WMR value was significantly elevated in NSTEMI individuals, compared to settings. Higher WMR was associated with higher SYNTAX score in individuals with NSTEMI. WMR 3-Hydroxydodecanoic ...
Low platelet count in pregnancy strikes 8% of women and the causes are different. As any other imbalance, the lack of platelets should always be monitored by the specialists.
Amgen today announced interim results from an open-label study showing that long-term administration (up to 48 weeks) of its investigational therapy AMG 531 was generally well-tolerated and stimulated platelet production in patients with immune thrombocytopenic purpura (ITP). Overall, 85 percent of patients in the study (29 of 34) achieved a platelet response, defined as doubling of the baseline platelet count and at least 50,000 platelets per microliter of blood.
We have hypothesized that androgen-mediated thrombocytosis promotes aggressive epithelial ovarian cancer biology. To test this hypothesis, we studied AR transactivation function indirectly through genotype analysis in a hospital-based cohort of women with epithelial ovarian carcinomas and examined clinical and pathologic findings in the context of preoperative platelet counts. Platelet expression of polymorphic ARs that correlate with transactivation function may differentially mediate release of angiogenic factors that function in ovarian cancer biology. We identified a statistically significant relationship between a short AR allelotype and preoperative thrombocytosis and found that the combination of short AR allelotype and thrombocytosis predicted decreased progression-free and overall survival. This combination was the sole independent predictor for suboptimal cytoreduction at initial exploratory surgery and approached statistical independence in multivariate analysis as a predictor for ...
Our data demonstrate thrombocytosis is associated with significantly increased 1-year mortality following admission with AECOPD. Thrombocytosis was associated with significantly increased inhospital mortality and correlated with markers of type II respiratory failure and exacerbation severity. Thrombocytosis was not associated with chronic comorbidities such as ischaemic heart disease, diabetes or renal impairment.. As with all association studies, our data cannot prove causation and the underlying mechanisms between thrombocytosis and death are not clear. McDonald et al demonstrated that 1-4 days of hypoxia resulted in thrombocytosis, and hypothesised that shedding of immature platelets from megakaryocytes was the mechanism.9 This hypothesis is supported by Wedzicha et al who established a negative correlation between mean platelet volume (MPV) and arterial oxygen tension,10 given that immature reticulated platelets have a larger MPV than mature circulating platelets. Larger, immature ...
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Platelets are parts of the blood that help the blood clot. They are smaller than red or white blood cells. ... A platelet count is a lab test to measure how many platelets you have in your blood. ... LOW PLATELET COUNT. A low platelet count is below 150,000 (150 × 109/L). If your platelet count is below 50,000 (50 × 109/L), ... A platelet count is a lab test to measure how many platelets you have in your blood. Platelets are parts of the blood that help ...
Recommended methods for the visual determination of white blood cell count and platelet count  ... Recommended methods for the visual determination of white cell and platelet counts / prepared on behalf of the World Health ...
People with thrombocytopenia have an abnormally low platelet count, which increases the risk of bleeding. Learn about the ... involving a platelet count of 101,000-140,000 per μl of blood, to very severe, where a person has a platelet count of 20,000 ... A low platelet count is a blood disorder that can sometimes be severe. Learn about the many possible causes of a low count, as ... Platelets are an essential component of the blood that helps with clotting. Learn how to increase platelet count naturally with ...
The association between platelet counts (PC) with clinical outcomes after ... Relation between platelet count and platelet reactivity to thrombotic and bleeding risk: from the assessment of dual ... How to cite this article: Hou X, Zheng Y, Wu T, Chen Y, Yang Y, Ma Y, Xie X. Baseline platelet count independently predicts ... However, the platelet count (PC) is not always parallel to its function. PLTs express and secrete many vasoactive substances, ...
His CBC was done and it showed platelet count 46,000. Please advise. ... Why does my brother have low platelet count?. Answered by: Dr Dharma R Choudhary , Clinical Hematologist & Bone Marrow ... Home » Frequently asked Questions on Health » Why does my brother have low platelet count? ... His CBC was done and it showed platelet count 46,000. Please advise. ...
Effects of high altitude and sea level on mean platelet volume and platelet count in patients with acute coronary syndrome. J ... Effects of high altitude and sea level on mean platelet volume and platelet count in patients with acute coronary syndrome. J ... This may help lower total platelet counts in your bloodstream. Talk to your doctor before using garlic to reduce platelet ... Check with your physician if you plan to use ginseng to address a high blood platelet count. In rare cases, it may contribute ...
A method for counting platelets in dilutions of platelet-rich plasm using the Coulter electronic counter is described.1 The ... results obtained show that such platelet counts are at least as accurate as the best methods of visual counting. The various ...
The platelet count test is done to detect the no of platelets present in your blood. Book platelet count blood test with... ... Platelet Count Test in Delhi - The platelet count test is done to detect the no of platelets present in your blood. Book ... Platelet Count Test in Delhi at Rs 45 only, Redcliffe Labs. Tags platelet count normal ...
... count and platelet-to-lymphocyte ratio (PLR) in eosinophilic gastroenteritis (EGE). Methods: In total, 91 patients with EGE and ... Blood cell count, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been considered as markers ... EO, eosinophil count; PLR, platelet-to-lymphocyte ratio; AUC, area under the curve; CI, confidence interval.. ... Objective: To evaluate the diagnostic value of eosinophil (EO) count and platelet-to-lymphocyte ratio (PLR) in eosinophilic ...
Causes of low platelet count during pregnancy. There are 3 most common causes of low platelet count during pregnancy:. 1. ... Platelets count tends to fall in first and second trimester and lowest platelet counts are seen most often during the third ... The clotting may result in low platelet count.. What further tests are required. Your doctor might ask for complete blood count ... It may target bone marrow, which is responsible for platelet formation. The affected bone marrow may cause low platelet count. ...
Clinical Quiz: A 25-Year-Old Woman with End-Stage Renal Disease, Low Platelet Count, and Skin Rash. * Share on Facebook ... Close more info about Clinical Quiz: A 25-Year-Old Woman with End-Stage Renal Disease, Low Platelet Count, and Skin Rash ... Close more info about Clinical Quiz: A 25-Year-Old Woman with End-Stage Renal Disease, Low Platelet Count, and Skin Rash ... low platelet count), and the lack of classification criteria for the diagnosis of SLE... Submit your diagnosis to see full ...
... of which 5 have not been associated with platelet count in previous GWAS. The novel genetic variants associated with platelet ... Several genetic variants associated with platelet count and mean platelet volume (MPV) were recently reported in people of ... Previously reported regions that were also significant in this study were 6p21, 6q23, 7q22, 12q24, and 19p13 for platelet count ... Genetic variants in ten independent regions were associated with platelet count (N = 16,388) with p<5×10(-8) ...
What happens if platelet count is low? ›. If left untreated, a low platelet count can be very serious because it can cause ... Low Platelet Count Causes (By MedicalCondition). The following medical conditions are observed to cause a low platelet count:. ... 10 Low Platelet Count Causes (Disease-Induced) (2022) Table of Contents. Low Platelet Count Causes (By MedicalCondition) 1. ... What is a low platelet count called? ›. Thrombocytopenia is a condition that occurs when the platelet count in your blood is ...
Mean Platelet Volume/Platelet Count Ratio and Culprit Plaque Morphologies: An Optical Coherence Tomography Study in Patients ... Mean Platelet Volume/Platelet Count Ratio and Culprit Plaque Morphologies: An Optical Coherence Tomography Study in Patients ... This study aimed to investigate the predictive value of mean platelet volume/platelet count ratio (MPR) for coronary plaque ... MPR showed better diagnostic performance than other platelet indices. The optimal MPR threshold ... ...
58 yrs old Male asked about Low Platelet count(125000, 1 doctor answered this and 9469 people found it useful. Get your query ... How to increase platelet count in dengue How to increase platelet count naturally Medicine to increase platelet count ... Platelet count 45000. 12387 Views My father had high fever with shiver two days back. His platelet count was 41k on the day ... Low platelets count during pregnancy. 244 Views Hello i am 8 month pregnant and my platelets count continues decrease now it is ...
LBXPLTSI - Platelet count (%) SI. Variable Name: LBXPLTSI. SAS Label: Platelet count (%) SI. English Text: Platelet count (%) ... LBXRBCSI - Red cell count SI. Variable Name: LBXRBCSI. SAS Label: Red cell count SI. English Text: Red cell count SI. Target: ... LBXMPSI - Mean platelet volume (fL). Variable Name: LBXMPSI. SAS Label: Mean platelet volume (fL). English Text: Mean platelet ... White blood cell count (SI). English Text: White blood cell count: SI. Target: Both males and females 1 YEARS - 150 YEARS. Code ...
Early studies suggested ITP was primarily due to immune-mediated peripheral platelet destruction. However, increasing evidence ... and increased platelet counts in most ITP patients following treatment with thrombopoietin receptor agonists. This review ... Studies supporting suppressed platelet production include: reduced platelet turnover in over 80% of ITP patients, morphological ... Pathogenesis of chronic immune thrombocytopenia: increased platelet destruction and/or decreased platelet production Br J ...
The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc ... The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. ... Even if the platelet count normalizes, many patients can maintain platelet counts of more than 20,000-30,000/µL with lower ... The platelet GP IIb/IIIa complex mediates platelet-to-platelet interactions (platelet aggregation). On resting platelets, GP ...
... know more about the platelet count in blood test, why it is needed, how to check platelet count and other important details. ... Does platelet count decrease with age?. The platelet count in individuals remains stable while they are in their middle age (25 ... A platelet count in blood tests means measuring the number of platelets present in an individuals body. Platelets, also known ... Having either a high platelet count or a low platelet count is hazardous for individuals. Thus, they are always advised to ...
Sunil Dargar, MBBS, MD, Pathologist, New Delhi, answered to the question - How reliable are platelets count? ... How reliable are platelets counts?. #aswift_1 { width: 100% !important; } Pathology & Lab Medicines. ... Sunil Dargar, MBBS, MD, Pathologist, New Delhi, answer "How reliable are platelets counts" ...
Absolute neutrophil count ,= 750/mm^3. *Platelet count ,= 30,000/mm^3. *Creatinine clearance ,= 30 mL/minutes ...
Any count is higher than this normal platelet count range, known as high platelet count, resulting in thrombocytopenia. ... What are platelet counts? Lower, higher, and normal range. Platelet counts are a method of measurement of the number of ... A low blood platelet count is also known as thrombocytopenia.. Platelets are a necessary blood component that helps your body ... However, when we do not have enough blood platelets in our bodies, blood clots cannot form. A low platelet count may also be ...
The Oxford-AstraZeneca vaccine may be associated with a condition characterised by low platelet counts, in rare cases, ... A low number of platelets - blood cells that help prevent blood loss when vessels are damaged - can result in no symptoms or ...
Platelet count in 51 highlanders was studied at high altitude. A group of 48 age and sex matched lowlanders were studied at Sea ... Platelet count in permanent residents of high altitude. Indian Journal of Physiology and Pharmacology. 1981 Jan-Mar; 25(1): 65- ... Highlanders had a significantly high platelet count. The results are reported and findings discussed. ...
A lack of platelets in your body may cause symptoms like fatigue, bleeding gums, easy bruising, et al. A low platelet count may ... white blood cells and platelets, also known thrombocytes. ... Low Blood Platelet Count Mild cases of low blood platelet count ... A lack of platelets in your body may cause symptoms like fatigue, bleeding gums, easy bruising, et al. A low platelet count may ... A lack of platelets in your body may cause symptoms like fatigue, bleeding gums, easy bruising, et al. A low platelet count may ...
... and low platelet syndrome: Outcomes for patients admitted to intensive care at a tertiary referral hospital. Download Prime ... Low platelet count; high AST, ALT, LDH, INR; and total bilirubin are associated with high mortality risk in this patient group ... Low platelet count; high AST, ALT, LDH, INR; and total bilirubin are associated with high mortality risk in this patient group ... In addition, low platelet count; low fibrinogen level; prolonged activated thromboplastin time; high INR; and high total ...
Dose-intensified GMA as reported in this study provided an encouraging short-term response rate of 70% in patients with moderately to severely active UC not responding to standard steroid or immunomodulator therapy. Although all patients relapsed not later than 16 weeks, GMA might be useful to reduce steroid and immunomodulator usage, or to delay surgery in this patient group.. ...
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... Creator Kaur, Prabhjot; Sharma, Vishakha; Garg, Nishtha. Date 2016. Type Text; ... Platelet count is a blood test which plays a very important role to evaluate the health as well as to diagnose and follow the ... Another method used for counting platelet is Advia hematology analyzer which is a very expensive machine, not affordable by ... We considered a concept for counting of platelets in microscopic blood cell images using Circular Hough Transform which uses ...
... from which it can be released during platelet activation. Activation-induced platelet spreading (Fig. 4E) and platelet counts ( ... A hemocytometer was used to count whole blood cells using transmitted light, and platelets counted using blue epifluorescence. ... Whole blood cell and platelet counts. Following dilution of 20 μl of blood with 30 μl acid-citrate-dextrose (ACD) buffer (85 mM ... E Activation-induced platelet spreading in platelets from BCre and B mice (t test: P = 0.836; n = 20 of each genotype from two ...

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