Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.
Starches that have been chemically modified so that a percentage of OH groups are substituted with 2-hydroxyethyl ether groups.
Reduction of blood viscosity usually by the addition of cell free solutions. Used clinically (1) in states of impaired microcirculation, (2) for replacement of intraoperative blood loss without homologous blood transfusion, and (3) in cardiopulmonary bypass and hypothermia.
The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Substances that are used in place of blood, for example, as an alternative to BLOOD TRANSFUSIONS after blood loss to restore BLOOD VOLUME and oxygen-carrying capacity to the blood circulation, or to perfuse isolated organs.
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.
Two-phase systems in which one is uniformly dispersed in another as particles small enough so they cannot be filtered or will not settle out. The dispersing or continuous phase or medium envelops the particles of the discontinuous phase. All three states of matter can form colloids among each other.
Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.
Loss of blood during a surgical procedure.
The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.
Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).
The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
Drugs considered essential to meet the health needs of a population as well as to control drug costs.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
Nonexpendable items used in examination.
A specialized agency of the United Nations designed as a coordinating authority on international health work; its aim is to promote the attainment of the highest possible level of health by all peoples.
Exclusive legal rights or privileges applied to inventions, plants, etc.
The area of a nation's economy that is tax-supported and under government control.
A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.
The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.
The sum of the weight of all the atoms in a molecule.
The study of the deformation and flow of matter, usually liquids or fluids, and of the plastic flow of solids. The concept covers consistency, dilatancy, liquefaction, resistance to flow, shearing, thixotrophy, and VISCOSITY.
The process of cleaving a chemical compound by the addition of a molecule of water.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Medical treatment for opioid dependence using a substitute opiate such as METHADONE or BUPRENORPHINE.
Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.
A purine base and a fundamental unit of ADENINE NUCLEOTIDES.
Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.
A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
Disorders related or resulting from abuse or mis-use of opioids.
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
The specialty related to the performance of techniques in clinical pathology such as those in hematology, microbiology, and other general clinical laboratory applications.
The grafting of bone from a donor site to a recipient site.
Products made by baking or firing nonmetallic minerals (clay and similar materials). In making dental restorations or parts of restorations the material is fused porcelain. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Boucher's Clinical Dental Terminology, 4th ed)
Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.
A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.
The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.
Therapeutic practices which are not currently considered an integral part of conventional allopathic medical practice. They may lack biomedical explanations but as they become better researched some (PHYSICAL THERAPY MODALITIES; DIET; ACUPUNCTURE) become widely accepted whereas others (humors, radium therapy) quietly fade away, yet are important historical footnotes. Therapies are termed as Complementary when used in addition to conventional treatments and as Alternative when used instead of conventional treatment.
Behavior exhibited by individuals who are overly suspicious, but without the constellation of symptoms characteristic of paranoid personality disorder or paranoid type of schizophrenia.
Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.
The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.
The concept concerned with all aspects of providing and distributing health services to a patient population.
Substances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed)
Flavoring agent sweeter than sugar, metabolized as PHENYLALANINE and ASPARTIC ACID.
Several clusters of chemoreceptive and supporting cells associated with blood vessels and nerves (especially the glossopharyngeal and vagus). The nonchromaffin paraganglia sense pH, carbon dioxide, and oxygen concentrations in the blood and participate in respiratory, and perhaps circulatory, control. They include the CAROTID BODY; AORTIC BODIES; the GLOMUS JUGULARE; and the GLOMUS TYMPANICUM.
Flavoring agent and non-nutritive sweetener.
Salts and esters of cyclamic acid.
The ability to detect chemicals through gustatory receptors in the mouth, including those on the TONGUE; the PALATE; the PHARYNX; and the EPIGLOTTIS.
Sucrose present in the diet. It is added to food and drinks as a sweetener.

Polymer structure and solubility of deoxyhemoglobin S in the presence of high concentrations of volume-excluding 70-kDa dextran. Effects of non-s hemoglobins and inhibitors. (1/379)

Earlier observations indicated that volume exclusion by admixed non-hemoglobin macromolecules lowered the polymer solubility ("Csat") of deoxyhemoglobin (Hb) S, presumably by increasing its activity. In view of the potential usefulness of these observations for in vitro studies of sickling-related polymerization, we examined the ultrastructure, solubility behavior, and phase distributions of deoxygenated mixtures of Hb S with 70-kDa dextran, a relatively inert, low ionic strength space-filling macromolecule. Increasing admixture of dextran progressively lowered the Csat of deoxyHb S. With 12 g/dl dextran, a 5-fold decrease in apparent Csat ("dextran-Csat") was obtained together with acceptable sensitivity and proportionality with the standard Csat when assessing the effects of non-S Hb admixtures (A, C, and F) or polymerization inhibitors (alkylureas or phenylalanine). The volume fraction of dextran excluding Hb was 70-75% of total deoxyHb-dextran (12 g/dl) volumes. Electron microscopy showed polymer fibers and fiber-to-crystal transitions indistinguishable from those formed without dextran. Thus when Hb quantities are limited, as with genetically engineered recombinant Hbs or transgenic sickle mice, the dextran-Csat provides convenient and reliable screening of effects of Hb S modifications on polymerization under near-physiological conditions, avoiding problems of high ionic strength.  (+info)

Resetting of exaggerated tubuloglomerular feedback activity in acutely volume-expanded young SHR. (2/379)

One purpose of the present study was to evaluate the ability of 7-wk-old spontaneously hypertensive rats (SHR) to reset tubuloglomerular feedback (TGF) activity in response to acute volume expansion (VE). Second, we evaluated the contribution of ANG II, via its action on AT1 receptors, to TGF control of glomerular function during VE. TGF was assessed by micropuncture methods and proximal tubular stop-flow pressure (SFP) determinations in SHR, Wistar-Kyoto rats (WKY), and Sprague-Dawley rats (SD). During euvolemia SHR exhibited enhanced TGF activity. In the same animals acute VE was achieved by infusion of saline (5 ml. h-1. 100 g body wt-1). VE led to resetting of TGF in all three strains. Maximal SFP responses, elicited by a 30-40 nl/min loop of Henle perfusion rate, decreased from 19 to 12 mmHg in SHR and, on average, from 11 to 5 mmHg in WKY and SD (P < 0.001). Tubular flow rate producing a half-maximal response (turning point) shifted to higher flow rates during VE, from 12 to 14 nl/min in SHR and from 15 to 19 nl/min in WKY. Administration of the AT1 receptor blocker candesartan (0.05 mg/kg iv) during sustained VE decreased TGF-mediated reductions in SFP in SHR and slightly increased the turning point in WKY. Nevertheless, other parameters of TGF activity were unaffected by AT1 receptor blockade. In conclusion, young SHR possess the ability to reset TGF activity in response to VE to a degree similar to compensatory adjustments in WKY. However, TGF remains enhanced in SHR during VE. ANG II and its action on AT1 receptors are in part responsible for the exaggerated SFP responses in young SHR during VE.  (+info)

Influence of right atrial pressure on the cardiac pacemaker response to vagal stimulation. (3/379)

We have recently shown that the intrinsic rate response to an increase in right atrial pressure is augmented when cardiac muscarinic receptors are activated. This present study examines the cardiac pacemaker response to vagal stimulation at different values of right atrial pressure in isolated rat right atrium and in the rabbit heart in situ. In the rat atrium, when pressure was raised in steps from 2 to 10 mmHg, there was a progressive reduction in the response to vagal stimulation [40.5 +/- 7.2% reduction (mean +/- SE) at 8 mmHg, P < 0.01], which was independent of the level of vagal bradycardia, that persisted in the presence of the beta-adrenergic agonist isoproterenol. In barbiturate-anesthetized rabbits with cervical vagi cut and beta-adrenergic blockade, raising right atrial pressure approximately 2.5 mmHg by blood volume expansion reduced the bradycardia elicited by electrical stimulation of the peripheral end of the right vagus nerve (9.1 +/- 1.1% reduction, P < 0.0001). These results demonstrate that vagal bradycardia is modulated by the level of right atrial pressure and suggest that normally right atrial pressure may interact with cardiac vagal activity in the control of heart rate.  (+info)

Effect of 20% in vitro haemodilution with warmed buffered salt solution and cerebrospinal fluid on coagulation. (4/379)

We have conducted an in vitro coagulation study consisting of two separate groups of 20 subjects using the thrombelastograph. In the first group, haemodilution was performed with a physiological balanced salt solution similar to plasma, with the exception of calcium, and buffered to a normal pH (Plasmalyte B) at 37 degrees C on blood obtained from consenting volunteers. In the second group, a protein-poor body fluid (cerebrospinal fluid (CSF)) obtained from parturient patients undergoing spinal anaesthesia for Caesarean section was used as the diluent. There were statistically significant differences between the warmed Plasmalyte B treated samples and their untreated controls for all variables measured by the thrombelastograph, except for maximum amplitude, and between the CSF treated samples and their untreated controls for all variables. We conclude that electrolyte and acid-base composition of the diluent fluid had no effect on the observation that crystalloid haemodilution produces hypercoagulability. The marked increase in coagulability produced by addition of CSF cannot be explained on a simple haemodilution basis and confirms previous suggestions of the presence of a procoagulant factor in CSF.  (+info)

Pseudo-proteinuria following gelofusine infusion. (5/379)

Transient massive proteinuria following cardiopulmonary bypass surgery was observed. It was characterized and attributed to post-operative gelofusine infusion. Gelofusine was found to interfere with dye binding but not immunochemical assays of proteinuria. Proteinuria following gelofusine infusion may not reflect underlying glomerular pathology.  (+info)

Effect of intravenous saline, albumin, or hydroxyethylstarch on blood volume during combined ultrafiltration and hemodialysis. (6/379)

It is generally advocated to use saline or albumin infusions during symptomatic hypotension during dialysis. However, because of their side effects and/or costs, they are of limited use. Hydroxyethylstarch (HES), a synthetic colloid with a long-standing volume effect, is used in the management of hypovolemia. In this study, the efficacy of three fluids (isotonic saline [0.9%], albumin [20%], and HES [10%]) was assessed during three treatment sessions with combined ultrafiltration and hemodialysis, which differed in the type of fluid given intravenously. Changes in relative blood volume (BV), systolic BP (SBP), and vascular reactivity (venous tone [VT]) were compared. An intravenous infusion of 100 ml of fluid was given when the decrease in BV versus baseline was more than 10% as measured by a continuous optical reflection method. The ultrafiltration was continued. BV decreased significantly versus baseline independent of the intravenous fluid administration in all three treatment sessions. However, when we compared BV values at the end of the dialysis session with those at the time of infusion, BV continued to decrease significantly with saline (change in BV -4.56 +/- 2.75%; P < 0.05) and albumin (change in BV -2.13 +/- 2.51%; P < 0.05), but not with HES (change in BV -0.15 +/- 2.17%; NS). Between albumin and HES there were no significant differences in changes in BV (NS), whereas between HES and saline (P < 0.05) and between albumin and saline (P < 0.05) the differences in BV changes were significant. SBP remained unchanged within each session. Although SBP tended to decrease more with saline compared to albumin and HES, the difference was not significant. The higher decrease in BV and SBP with saline was counterbalanced by a significantly higher increase in VT, while VT remained unchanged in the other two sessions. It is concluded that HES is a promising fluid in preserving blood volume, comparable to albumin, but superior to saline.  (+info)

Plasma volume expansion with solutions of hemoglobin, albumin, and Ringer lactate in sheep. (7/379)

We have measured plasma volume expansion (Evans blue and hematocrit changes) and hemodynamic responses in conscious hemorrhaged and normovolemic splenectomized sheep after a 30-min infusion of either 20 ml/kg of diaspirin cross-linked hemoglobin (DCLHb), 20 ml/kg of human albumin (Alb), or 60 ml/kg of a solution of Ringer lactate (RL). All regimens expanded blood volume and increased blood pressure and cardiac output after hemorrhage. However, only 15 +/- 3% of the infused volume of RL was evident as intravascular expansion 10-min postinfusion, compared with 67 +/- 16% and 139 +/- 139% for Alb and DCLHb, respectively. DCLHb infusions were associated with higher blood pressures and lower cardiac outputs compared with RL and Alb infusions, but the increased oxygen content of blood with DCLHb resulted in systemic delivery of oxygen similar to that of the other infusions. These differences in hemodynamics and vascular volume continued for 6 h, and at 24 h vascular volume and all hemodynamics were similar in all three groups. The better volume expansion with DCLHb may be due to greater mobilization of endogenous interstitial protein or reduced transcapillary loss as total intravascular endogenous plasma protein increased after infusion of DCLHb, whereas there was an apparent loss of endogenous intravascular protein after infusions of Alb and RL. Vasoconstriction by DCLHb is one mechanism that could lower blood-to-tissue transport of fluid and protein. In addition to its oxygen-carrying capacity and vasoactivity, DCLHb is associated with volume expansion properties out of proportion to its colloid osmotic pressure.  (+info)

Thrombelastogram reveals hypercoagulability after administration of gelatin solution. (8/379)

We have compared the effects of gelatin, low molecular weight hydroxyethyl starch (HES) or albumin on tests of haemostasis and on the thrombelastogram in 42 ASA I patients undergoing total hip or knee replacement. Patients were allocated randomly to receive one of the three blood substitutes to obtain moderate intraoperative haemodilution. Blood loss and packed red cell infusion was the same in each group. A greater amount of gelatin was given (1.5 times the measured blood loss) because of its shorter half-life. There was a statistically significant but clinically negligible decrease in platelets count, prothrombin time and fibrinogen, and an increase in bleeding time in all groups. Platelets were slightly but significantly lower after HES. Haemodilution was comparable between groups. TEG showed a state of hypercoagulability in the gelatin group with a significant decrease in r, r + k and an increase in alpha angle.  (+info)

A comparative study of the effects of plasma substitutes on apparent blood viscosity was made at low and high shear rates. Red cells from normal donors were resuspended in their own plasma diluted with plasma substitutes or saline. The haematocrit wa
OBJECTIVE: To compare the effects of different colloid plasma substitutes on blood coagulation and postoperative blood loss. DATA SOURCES: Relevant studies were obtained from the medical literature. STUDY SELECTION: Articles were selected that provided data on the effects of colloids on hemostasis and postoperative blood loss in humans. Studies comparing different colloids were looked for using MEDLINE and by searching through the references of studies as they were collected. DATA SYNTHESIS: Articles were reviewed and relevant data were extracted and partly presented in comparative tables. CONCLUSIONS: Dextran, gelatin, and hydroxyethyl starch (HES) all can induce a specific decrease of von Willebrand factor and factor VIII:c. Blood coagulation is most impaired by dextran and high molecular weight HES, both associated with increased postoperative blood loss. The effects of HES on blood coagulation have been shown to depend on its molecular weight and rate of elimination. Detrimental effects have ...
Intravenous solutions with dextran function both as volume expanders and means of parenteral nutrition. See the range of Pharmacosmos Dextran
High-molecular weight dextran is a plasma volume expander made from natural sources of sugar (glucose). It works by restoring blood plasma lost through severe bleeding. Severe blood loss can decrease oxygen levels and can lead to organ failure, brain damage, coma, and possibly death. Plasma is needed to circulate red...
BioTime, Inc. was incorporated in 1990 in the state of California. It is a biotechnology company engaged in two areas of biomedical research and product development. The Company has historically developed blood plasma volume expanders and related technology for use in surgery, emergency trauma treatment and other applications. Its focus is in the field of regenerative medicine; specifically human embryonic stem (hES) cell and induced pluripotent stem (iPS) cell technology. Regenerative medicine refers to therapies based on stem cell technology that are designed to rebuild cell and tissue function lost due to degenerative disease or injury. hES and iPS cells provide a means of manufacturing every cell type in the human body and therefore show considerable promise for the development of a number of new therapeutic products. The Company plans to develop stem cell products for research and therapeutic use through its subsidiaries. OncoCyte Corporation is developing products and technologies to ...
Under normal conditions, blood flow in the renal arterial circulation is antegrade and maintained during diastole. When renal arterial vascular resistance increases or compliance lessens, a decrease in renal diastolic blood flow occurs, which is more pronounced than the decrease in the systolic component (11). This action results in an increased RI. Importantly, the Doppler waveform is altered not by vascular resistance alone but by the interaction of vascular resistance and compliance (e.g., large arterial distensibility, pulse pressure). Therefore, aging, atherosclerosis, and stiffening of the large arteries will result in an increased RI (12). This scenario likely explains the significantly lower baseline RI value in the cohort of healthy young subjects compared with HF patients.. Baseline levels of VII were not different between groups. After multivariate analyses, there was a poor but significant correlation between RVSP and baseline VII, but no significant correlation remained between ...
Expander definition is - one that expands; specifically : any of several colloidal substances (such as dextran) of high molecular weight used as a blood or plasma substitute for increasing the blood volume.
Octalbin: Albumin belongs to the group of medications known as plasma substitutes. Albumin is made by the liver and is a naturally-occurring protein found in plasma (the fluid that carries blood cells). It helps to transport a number of the bodys substances (e.g., bilirubin) via the blood by attaching itself to them.
The reliability of an infusion of 500 ml cold or room temperature 6% dextran 70 in normal saline as a volume expander was studied in eleven subjects after removal of 500 ml blood. Changes in blood...
Relationship between cardiac output and cerebral blood flow in patients with intact and with impaired autoregulation.: Intravascular volume expansion has been s
Your account has been temporarily locked Your account has been temporarily locked due to incorrect sign in attempts and will be automatically unlocked in 30 mins. For immediate assistance, contact Customer Service: 800-638-3030 (within USA), 301-223-2300 (international) [email protected] ...
Review for Laboratorie Remede, Laboratorie Remede Complete Treatment Anti-aging/Stress Control, Body Lotion. Read more Laboratorie Remede product reviews at Total Beauty.
A case of acute renal failure due to Hydroxyethyl Starch,Hydroxyethyl Starch (HES) commonly is widely used as plasma volume expander. They are often used preoperatively and in cases of hypovolemia.
Hepworth-Warren KL, Hay Kraus BL, Wong DM and Metcalf GL. Clinical use of a low molecular weight/ low molar substitution hydroxyethyl starch solution (130/0.4) in a Percheron mare with septic peritonitis caused by Clostridium haemolyticum. Submitted to Equine Veterinary Education, April 2015.. Hepworth-Warren KL, Wong DM, Hay Kraus BL, Wang C and Sun Y. Effects of Administration of a Synthetic Low Molecular Weight/Low Molar Substitution Hydroxyethyl Starch Solution on Physical Examination and Clinicopathologic Parameters in Healthy Neonatal Foals. Canadian Journal of Veterinary Research, Accepted for Publication, January 2015.. Hay Kraus BL. Effect of dosing interval on efficacy of maropitant for prevention of hydromorphone-induced vomiting and signs of nausea in dogs. The Journal of the American Veterinary Medical Association. 245(9):1015-20, Nov 1, 2014.. Hay Kraus BL. Anti-cholinergic Drugs in Dogs. Vet Pulse, Iowa State University College of Veterinary Medicine. Vol. 1, Number 3. September ...
patient will receive 6% HES 130/0.42 in a balanced electrolyte containing Na+140 mmol/L, Cl- 118 mmol/L, K +4 mmol/L, Ca++ 2.5 mmol/L, Mg++ 1 mmol/L, acetate- 24 mmol/L and malate-- 5 mmol/ ...
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Patients undergoing cardiac surgery with cardiopulmonary bypass require significant fluid administration. Fluids are used routinely to replace blood lost during and after surgery. Significant amounts of fluid are also used to prime the tubing and components of the cardiopulmonary bypass pump before and during its use. The use of Pentaspan - a synthetic pentastarch - was started because of the restriction of use for blood and blood products, particularly albumin. Pentaspan is usually used after surgery in the Intensive Care Unit (ICU). The impact of the use of pentastarch on coagulation, fluid balance and bleeding are very limited. This study will methodically evaluate the impact of using increasingly greater amounts of pentastarch during surgery on an open heart surgery patients recovery in particular - is there more bleeding, does his/her blood clot as well, and how much fluid overall is used and excreted ...
BACKGROUND AND OBJECTIVE: The effects of administering albumin 5%, hydroxyethylstarch 6% and succinylated gelatine 4% on oxygen transport and left ventricular function were prospectively investigated in different experimental conditions: baseline, fluid load, after 10 min of myocardial ischaemia and after reperfusion. METHODS: Twenty-seven rabbits received at random one of three colloids in escalating boluses over 10-15 min to achieve left ventricular end-diastolic pressures (LVEDP) between 8 and 10mmHg. A branch of the left anterior descending coronary artery was then temporarily occluded by a ligature and released after 10 min. Myocardial function was assessed using left ventricular pressure recordings and dimension data obtained from ultrasound crystals inserted onto the ventricular wall. Blood was sampled for the determination of oxygen delivery and consumption, the oxygen extraction ratio, acid-base status, and glucose and lactate concentrations. RESULTS: Administration of the colloids ...
Plasma Exchange (PLEX) if no improvement occurs with corticosteroids. The goal of PLEX is to lower the level of NMO-IgG in the blood.PLEX involves removing blood from the body through a needle and tubing. Through a series of steps, the plasma (the liquid part of the blood) is separated from blood cells and replaced with an artificial plasma substitute; the plasma substitute and blood cells are combined and returned to the body through an intravenous line. The procedure lasts several hours and may be repeated multiple times over a number of days ...
Professional guide for Hetastarch (Hydroxyethyl Starch; HES). Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URACs accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch ...
Advice and warnings for the use of Hydroxyethyl starch (Voluven) during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out
Objective: to compare diafiltered 6% pentastarch (Pentafraction-PDP, MWn 120000 and MWw 280000) and native pentastarch (Pentaspan-PSP, MWn 63000 and MWw 2
Research Report on 2017-2022 Hydroxyethyl Starch Report on Global and United States Market, Status and Forecast, by Players, Types and Applications. The Report includes market price, demand, trends, size, Share, Growth, Forecast, Analysis & Overview.
Dr. Fowler responded: Hetastarch. Hetastarch (Hespan / hydroxyethyl startch) is a starch that is used to expand plasma. It has been used to ^ plasma volume related to |a href=/topics/shock track_data={
article{f23cdbe5-c459-4135-8a0e-eac919072a8d, abstract = {Complement activation was studied in 45 patients undergoing total hip arthroplasty under epidural anesthesia. The patients were randomly allocated to three groups. In Group I blood loss was replaced with microaggregate-poor erythrocyte concentrate (SAGM-ERC) plus 3% dextran-60 as plasma substitute, and postoperative analgesia was maintained with intramuscular ketobemidone. In Group II blood loss was replaced as in Group I, but epidural anesthesia was prolonged 12 h postoperatively and kept at a level of T4 with 0.5% bupivacaine. In Group III blood loss was replaced with non-frozen stored plasma plus SAGM-ERC, and postoperative analgesia was maintained with ketobemidone as in Group I. All groups received pre- and postoperative thrombo-prophylaxis with dextran. The plasma concentration of C3a-des-arginine (C3a-desArg) was measured by radioimmunoassay preoperatively, immediately after operation and 3, 6 and 18 h postoperatively. No ...
Blood transfusions are crucial for the successful treatment of many diseases and injuries. However, as we all know, donated blood can often be in short supply. Further, donated blood must always be screened for carrier diseases. In this study, the researchers aim to develop an encapsulation system for hemoglobin (a key component of blood transfusions) which can one day be used as a substitute for donated blood in the clinic. The researchers used PEG (polyethylene-glycol) and PCL (poly caprolactone) as starting materials to build what they term polymersomes, or triblock copolymers consisting of a water-insoluble PCL segment and two water-soluble PEG chains. The hemoglobin-polymer aggregates were mixed into blood plasma substitute solutions. Once encapsulated, the hemoglobin-containing particles were studied to determine that the hemoglobin continued to be reactive. Most importantly, the researchers demonstrated that the encapsulated hemoglobin could continue to bind oxygen. Ascorbic acid was ...
Plasma is a fluid that is part of the blood. It contains proteins that can make your kidneys inflamed. Plasma exchange involves removing some of the plasma from your blood.. During the procedure, youre connected to a machine that gradually removes some of your blood. The plasma is separated from the blood cells and removed. A plasma substitute is then added to the blood before its put back into your body.. Plasma exchange may be used in certain circumstances if your condition is severe.. Read more about plasma. ...
Hypotension is common during surgery and is often treated with intravenous fluid. The choice of fluid depends mainly on local tradition, and colloids were often selected over crystalloids because of their expected ability to expand plasma volume more effectively. Current guidelines do not recommend choosing colloids over crystalloids1 as improvements in outcome have never been established,2 3 but debate continues on the use of colloids in this setting.. In a linked study Opperer and colleagues (doi:10.1136/bmj.h1567) report a retrospective population based analysis in which they evaluated postoperative complications among patients given hydroxyethyl starch, albumin, or crystalloids during or soon after elective joint surgery.4 From a databases containing procedural codes, ICD-9 diagnosis codes, and prescription data, the authors identified a million patients who underwent elective hip and knee replacement surgery during 2009-13 in the United States. The use of either hydroxyethyl starch or ...
NCI supports clinical trials that test new and more effective ways to treat cancer. Find clinical trials studying balanced crystalloid solution.
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To test the hypothesis that lowering the haemoglobin concentration pre-operatively improves wound healing 52 Wistar rats were randomly allocated into two groups: group A were haemodiluted pre-operatively by ten per cent of their blood volume; group
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Efek samping dari pemberian HES (Hydroxyethyl Starch) yang paling dikhawatirkan ialah penurunan fungsi ginjal. Efek samping tersebut diperkirakan memi...
This page contains information on the chemical Ammonium, methyltris(2-hydroxyethyl)-, chloride including: 5 synonyms/identifiers.
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In this study, HS-HES and mannitol were both effective in reducing elevated ICP. HS-HES seemed to lower the ICP more effectively, but comparison between the 2 treatments has its limitations, since the optimum dose and infusion rate are largely unknown for both substances. Because of the lack of exact experimental or clinical data, dose, and mode of application, the end point of 10 minutes after the end of infusion for determining efficacy and the definition of treatment success in our clinical study are based primarily on personal experiences and general recommendations. Although mannitol is used in many patients with intracranial hypertension, larger dose-finding studies in humans have not been performed. Single doses of mannitol from 0.25 up to 2.27 g/kg body wt have been used.5 27 28 29 Marshall et al4 studied the effect of different mannitol doses in 8 patients and concluded that small doses (0.25 g/kg) were as effective as larger doses. Our dose of 40 g mannitol equals approximately 0.4 ...
Click the title to purchase the article.. Summary:. We have evaluated the effect of a colloid solution on acute kidney injury in paediatric cardiac surgery. A total of 195 patients were ramdomly divided into an hydroxyethyl starch group and a control group. In the starch group, 6% hydroxyethyl starch 130/0.4 (Volulyte®) was used as the primary fluid for volume resuscitation but was limited to 30 ml.kg−1. In the control group, only crystalloid fluid was used during the peri-operative period. The incidence of acute kidney injury, peri-operative transfusion, clinical outcomes and laboratory data were compared. The incidence of acute kidney injury determined by Paediatric Risk, Injury, Failure, Loss, End-stage renal disease (pRIFLE) and Acute Kidney Injury Network (AKIN) criteria were no different between the two groups (starch group 40.8% vs. control group 30.0%; p = 0.150 using pRIFLE; 19.6% vs. 21.1% respectively, p = 0.602 using AKIN). There were no differences in clinical outcomes such as ...
TY - JOUR. T1 - Rheological properties of hemoglobin vesicles (artificial oxygen carriers) suspended in a series of plasma-substitute solutions. AU - Sakai, Hiromi. AU - Sato, Atsushi. AU - Takeoka, Shinji. AU - Tsuchida, Eishun. PY - 2007/7/17. Y1 - 2007/7/17. N2 - Hemoglobin vesicles (HbV) or liposome-encapsulated Hbs are artificial oxygen carriers that have been developed for use as transfusion alternatives. The extremely high concentration of the HbV suspension (solutes, ca. 16 g/dL; volume fraction, ca. 40 vol%) gives it an oxygen-carrying capacity that is comparable to that of blood. The HbV suspension does not possess a colloid osmotic pressure. Therefore, HbV must be suspended in or co-injected with an aqueous solution of a plasma substitute (water-soluble polymer), which might interact with HbV. This article describes our study of the rheological properties of HbV suspended in a series of plasma substitute solutions of various molecular weights: recombinant human serum albumin (rHSA), ...
In the acute normovolemic hemodilution group, intraoperative blood collection was performed to a target hemoglobin of 8.0 g/dL. Low central venous pressure anesthetic technique was used intraoperatively for both groups. A standardized transfusion protocol was applied to all patients intraoperatively and throughout the hospital stay.. The researchers randomized 63 patients to acute normovolemic hemodilution, and 67 to standard anesthetic management from 2004 to 2007.. Demographics, diagnoses, liver function, extent of resection, intraoperative blood loss, operative time, incidence and grade of complications, and length of hospital stay were similar between the 2 groups. The team found that acute normovolemic hemodilution reduced the overall allogeneic red cell transfusion rate by 50% compared with standard anesthetic management. Acute normovolemic hemodilution patients were less often transfused intraoperatively compared with the standard anesthetic management group.. The research team noted that ...
TY - JOUR. T1 - Acute volume expansion with colloid increases oxygen delivery and consumption but does not improve the oxygen extraction in severe preeclampsia. AU - Belfort, Michael A.. AU - Saade, George R.. AU - Wasserstrum, Nathan. AU - Johansen, Richard. AU - Anthony, John. PY - 1995/1/1. Y1 - 1995/1/1. N2 - The objective of this study was to determine the effect of volume expansion with colloid on oxygen consumption (VO2), oxygen delivery (DO2) and the oxygen extraction ratio in patients with severe preeclampsia. The study was prospective and descriptive and took place in the tertiary care labor and delivery unit in a university hospital. Fourteen women with severe preeclampsia who received a pulmonary artery catheter and radial arterial line to monitor their hemodynamic and respiratory status took part in the study. Patients who had received prior medication or volume expansion were excluded. The intervention employed was acute volume expansion, using colloidal solutions (Dextran 70 or ...
Hydroxyethyl starch(HES) has been used for volume resuscitation. It is amylopectin+ hydroxyethyl groups in 0.9% saline or LR. 40-64% of it is excreted by the kidneys. It is reabsorbed via pinocytosis and no enzymes exist to metabolize the intracellular substances and this leads to accumulation of cellular water and osmotic damage. This can also be seen in IV sucrose or dextran induced injury. This is similar to some forms of IVIG induced injury. Risk factors associated with renal injury have been described as prior CKD, DM, old age, large HES volumes,1 liter. We as nephrologists have always been skeptical of this agent as its association with osmotic nephrosis. The first case evert described of osmotic nephrosis with HES was in a kidney transplant patient. A recent NEJM publication looked at a multi centered, blinded trial that randomly assigned patients with severe sepsis to either 6% HES or LR at a dose of 33ml/kg of IBW per day. The outcome was death and dependence of dialysis. The results ...
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Plasmapheresis is a process in which the liquid in the blood, or plasma, is separated from the cells. In sick people, plasma can contain antibodies that attack the immune system. A machine removes the affected plasma and replaces it with good plasma, or a plasma substitute. Aadil Hospital follows all rules and regulation of Punjab Blood Banking Act. Blood bank shall issues cross match card with donors blood and would adhere to instructions of MSDS and Punjab blood transfusion authority. The Aadil Hospital Blood transfusion committee over sees the transfusion practice and compromise of • Director Admin • Surgical Specialist • Medical Specialist • Pathologists • Microbiologist/Infection Control Officer • Blood Bank In-charge • C.M.Os • O.T In-charge • Matron Special emphasis is laid on ISO, Quality
Science can do more than improve peoples lives; sometimes it can save them.. Consider the contributions of the late Allene Rosalind Jeanes, an Agricultural Research Service (ARS) chemist at what is now the National Center for Agricultural Utilization Research in Peoria, Illinois. Her efforts are particularly worth celebrating this Veterans Day.. Jeanes studied polymers (large molecules composed of many repeated subunits) found in corn, wheat and wood. She spent long hours investigating how bacteria could produce polymers in huge fermentation vats. Eventually, she found a way to mass produce dextran, a type of polymer, so that it could be used as a blood volume expander to sustain accident and trauma victims who have lost massive amounts of blood and need to get to a hospital for a transfusion.. The technology is credited with saving the lives of numerous battle-wounded Americans in Korea and Vietnam, and is one reason why Jeanes, who died in 1995, is still remembered by some of her former ...
LEVOPHED should not be given to patients who are hypotensive from blood volume deficits except as an emergency measure to maintain coronary and cerebral artery perfusion until blood volume replacement therapy can be completed. If LEVOPHED is continuously administered to maintain blood pressure in the absence of blood volume replacement, the following may occur: severe peripheral and visceral vasoconstriction, decreased renal perfusion and urine output, poor systemic blood flow despite normal blood pressure, tissue hypoxia, and lactate acidosis.. LEVOPHED should also not be given to patients with mesenteric or peripheral vascular thrombosis (because of the risk of increasing ischemia and extending the area of infarction) unless, in the opinion of the attending physician, the administration of LEVOPHED is necessary as a life-saving procedure.. Cyclopropane and halothane anesthetics increase cardiac autonomic irritability and therefore seem to sensitize the myocardium to the action of ...
(1998) Behne et al. Anesthesia and Analgesia. Acetyl starch (ACS) is a new synthetic colloid solution for plasma volume expansion and is now undergoing phase 2 clinical trials. We compared the pharmacokinetics of ACS with those of hydroxyethyl...
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Volulyte New Safety Information. Balanced Voluven®. Volulyte is composed of the identical colloid as in Voluven, hydroxyethyl starch (HES 130/0.4). To further improve the safety profile of HES 130/0.4, the 0.9% NaCl carrier solution of Voluven has been replaced with a balanced electrolyte solution and branded as Volulyte. ...
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In the 200 ml group, 10 min after the end of volume expansion, the increase in MSAP and CVP disappears, whereas ITBV, CI and SI increases remain unchanged and even shows for ITBV a trend toward increase. This suggest a post-expansion effect which is not observed on CVP values. In group 2 who had a higher baseline CVP and a lower volume expansion, the increases in MSAP, CVP, ITBV and SI observed at the end of volume expansion disappear 10 min later, suggesting the absence of a post-expansion effect when the baseline CVP is high and/or the volume infused is low. ...
Intravenous 4% succinylated gelatine fluid at a dose of at least 500mL, to be delivered over less than 60 minutes, Exact dose will be determined by treating physician. The study fluid will also be used for any further fluid boluses required within the next 24-hour period, up to a maximum of 50mL/kg or 3000mL. Any fluid required for blood volume expansion beyond 24 hours is open-label; however, the use of gelatine will be not allowed for 7 days post-enrolment. Other crystalloid fluids or blood products may be used for purposes other than blood volume expansion, such as maintenance requirements or transfusion. Use of albumin solution is also permitted, if specifically indicated. Volume and type of all fluids delivered with 7 days of enrolment, or until ICU discharge, will be recorded. ...
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This randomized crossover study in healthy subjects showed no differences in the blood volume-expanding properties of 6% hydroxyethyl starch suspended in a balanced solution or 0.9% saline. Hyperchloremia occurred with the latter. The former produced an increase in renal cortical tissue perfusion, a phenomenon not seen with the latter ...
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Plasma substitutes[edit]. *Dextran 70[note 67]. Cardiovascular medicines[edit]. Antianginal medicines[edit]. *Bisoprolol[note ... Blood products of human origin and plasma substitutes[edit]. Blood and blood components[edit]. ... 11 Blood products of human origin and plasma substitutes *11.1 Blood and blood components ... Plasma-derived medicines[edit]. Human immunoglobulins[edit]. *Rho(D) immune globulin (anti-D immunoglobulin) ...
Blood Substitutes, and Plasma Expanders". Burger's Medicinal Chemistry, Drug Discovery and Development. doi:10.1002/0471266949. ... Efaproxiral can be absorbed via transdermal, rectal, inhalation and gastrointestinal routes, though not at plasma ...
... and its use in a dextran-based blood plasma extender. This plasma substitute was used by medical personal in the Korean and ... a substance that replaced plasma in the Korean War. A member of the American Chemical Society, Jeanes published over 60 works, ...
Albumin was an excellent substitute for human plasma in World War Two. When administered to wounded soldiers or other patients ... Human plasma proved to have several useful components other than albumin. Human blood plasma fractionation yielded human serum ... In heat ethanol, the plasma is heat treated at 68 degrees C with sodium octanoate with 9% ethanol at pH of 6.5. This results in ... Generally, if the yield is high, the purity is lowered, to roughly 85-90%. Cohn was able to start the Plasma Fractionation ...
He helped to develop bacterial polyglucose dextran as a blood plasma substitute. Stacey was awarded the Meldola Medal of the ...
Antihypertensive drugs and plasma lipids". Br Heart J. 66 (6): 409-410. doi:10.1136/hrt.66.6.409. PMC 1024812. PMID 1772705. ... Swales, J. D. (2 November 1991). "Salt substitutes and potassium intake". BMJ. 303 (6810): 1084-1085. doi:10.1136/bmj.303.6810. ... Arterial wall or plasma renin in hypertension?" (PDF). Clinical Science. 56 (4): 293-298. doi:10.1042/cs0560293. Archived from ...
Rockets can be substituted for small nuclear missiles capable of destroying plasma bugs and wounding other large enemies. ... Plasma Bugs - The Bug artillery, they are bigger than the Tanker Bugs, and have the rather nasty ability to fire huge, volatile ... One of the roughneck missions was to attempt to capture a baby one alive so researchers could find out how this plasma is ... Their armored exoskeleton makes them impervious to everything except high explosives such as mini-nukes and plasma rockets. ...
Lactated Ringer's solution is another isotonic crystalloid solution and it is designed to match most closely blood plasma. If ... Blood transfusion is the only approved fluid replacement capable of carrying oxygen; some oxygen-carrying blood substitutes are ...
Meanwhile, Ferrari worked as a substitute teacher and the group donated plasma to fund their tours. The Pink Spiders also ...
Among the projects he worked on was a blood plasma substitute, of potential value to the military.) His Air Force time was ...
... plasma; and cryoprecipitate. Plasma derivatives are plasma proteins prepared under pharmaceutical manufacturing conditions, ... Blood products may also be called blood-based products to differ from blood substitutes, which generally refer to artificially ... This includes whole blood; blood components; and plasma derivatives. Whole blood is not commonly used in transfusion medicine. ... Cryoprecipitate Cryosupernatant Fresh frozen plasma PF24 Platelet transfusion Red blood cells The Clinical Use of Blood ...
"Plasma cholesteryl ester transfer protein activity is increased when trans-elaidic acid is substituted for cis-oleic acid in ... Elaidic acid increases plasma cholesterylester transfer protein (CETP) activity which lowers HDL cholesterol. Oleic acid Tardy ...
Plasmapheresis, wherein blood is withdrawn and filtered, having the plasma removed and substituted, and returned to the patient ... a blood substitute solution of chemically modified human hemoglobin. Hemopure, a blood substitute solution of chemically ... Platelet factor 4 Fractions from blood plasma: Albumin Globulins Cryoprecipitate Cryosupernatant (cryo-poor plasma) Clotting ... This includes the use of red blood cells, white blood cells, platelets and blood plasma. Other fractions derived from blood are ...
Plasmapheresis, wherein blood is withdrawn and filtered, having the plasma removed and substituted, and returned to the patient ... PolyHeme, a blood substitute solution of chemically modified human hemoglobin.[22]. *Hemopure, a blood substitute solution of ... This includes the use of red blood cells, white blood cells, platelets and blood plasma. Other fractions derived from blood are ... Cryosupernatant (cryo-poor plasma)[27]. *Clotting factors, including Factor VIII and Factor IX derived from large quantities of ...
Favorable characteristics in an NS5A inhibitor include high potency and long plasma half-life in order to achieve a once-daily- ... Symmetrical bis-imidazol structures, such as daclatasvir, experience a loss in potency when fluorene is substituted for the ... Additionally, it provides improved bioavailability and more favorable plasma half-life. There is also a remarkable increase in ...
For instance, levels for screen format may be LED, LCD, or Plasma. Respondents are shown a set of products, prototypes, mock- ... Each example is similar enough that consumers will see them as close substitutes but dissimilar enough that respondents can ...
"Plasma cholesteryl ester transfer protein activity is increased when trans-elaidic acid is substituted for cis-oleic acid in ...
"Plasma cholesteryl ester transfer protein activity is increased when trans-elaidic acid is substituted for cis-oleic acid in ... Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the ... Okajima F (March 2002). "[Distribution of sphingosine 1-phosphate in plasma lipoproteins and its role in the regulation of the ...
The name stems from the fact that it is methane (CH4) with a fluorine atom substituted for one of the hydrogen atoms. It is ... used in semiconductor manufacturing processes as an etching gas in plasma etch reactors. The compound is the lowest mass member ...
"The Chemical Treatment of Protein Solutions in the Attempt to Find a Substitute for Human Serum for Transfusions". His project ... group, which included J.B. Koepfli and Dan Campbell, developed a possible replacement for human blood plasma in transfusions: ...
On the other hand, mammalian CPE synthase that is on the plasma membrane, SMS2, is a bifunctional enzyme that produces both CPE ... This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. ... and the other one is associated with the plasma membrane. The endoplasmic reticulum-resident CPE synthase, SMSr, is identified ... Sphingomyelin and ceramide-phosphoethanolamine synthesis by microsomes and plasma membranes from rat liver and brain. J. Lipid ...
It is a member of the substituted amphetamine, substituted cathinone and substituted methylenedioxyphenethylamine classes. ... Cozzi NV, Sievert MK, Shulgin AT, Jacob P, Ruoho AE (September 1999). "Inhibition of plasma membrane monoamine transporters by ... Methylone substitutes for MDMA in rats trained to discriminate MDMA from saline. Methylone does not substitute for amphetamine ... Methylone is the substituted cathinone analog of MDMA and the 3,4-methylenedioxy analog of methcathinone. The only structural ...
Another important benefit of CGMP is that the taste is significantly improved[40] when CGMP substitutes part of the free amino ... and will therefore help maintain plasma phe levels in the target range. ... In 2018, the FDA approved an enzyme substitute called pegvaliase which metabolizes phenylalanine.[4] It is for adults who are ... Lower-protein "medical food" substitutes are often used in place of normal bread, pasta, and other grain-based foods, which ...
Infected human red blood cells are incubated in a culture dish or flask at 37 °C together with a nutrient medium and plasma, ... Experimental studies on serum substitutes and supplements and alternative culture media for in vitro drug sensitivity assays ... serum or serum substitutes. A special feature of the incubation is the special gas mixture filled with Nitrogen (90-92 %) CO2 ( ...
PVP was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, ... PVP was used as a plasma volume expander for trauma victims after the 1950s. It is not preferred as volume expander due to its ...
These are then further metabolized by conjugation with glucuronic acid to form a glucuronide.[citation needed] The plasma half- ... Naltrexone can be described as a substituted oxymorphone - here the tertiary amine methyl-substituent is replaced with ... "simply substitute[s]" for "illicit drugs" whereas according to the letter, "the substantial body of research evidence ...
In these applications NF 3 is initially broken down within a plasma. The resulting fluorine radicals are the active agents that ... NF3 has also been promoted as an environmentally preferable substitute for SF 6 or PFCs such as hexafluoroethane. The ... H. Reichardt , A. Frenzel and K. Schober (2001). "Environmentally friendly wafer production: NF 3 remote microwave plasma for ... utilization efficiency of the chemicals applied in plasma processes varies widely between equipment and applications. A ...
... acting as a substitute for the deuterium and tritium fuel capsules that will be used later on. Plasma Physics Group Leader Dr. ... Due to the size of the test hohlraums, laser/plasma interactions produced plasma-optics gratings, acting like tiny prisms, ... They feature a small plastic ring around the "equator" of the target, which quickly vaporizes into a plasma when hit by the ... Some of the laser light is refracted through this plasma back towards the equator of the target, evening out the heating. ...
Ideally, this is achieved by isovolemia exchange transfusion of a plasma substitute with a colloid osmotic pressure (OP). A ... Typical values for the viscosity of normal human plasma at 37 °C is 1.4 mN·s/m2. The viscosity of normal plasma varies with ... Blood is composed of plasma and formed elements. The plasma contains 91.5% water, 7% proteins and 1.5% other solutes. The ... Hemodilution is the dilution of the concentration of red blood cells and plasma constituents by partially substituting the ...
Plasma protein binding is 60 to 80%. While the substance is metabolised in the liver, 30% are excreted in unchanged from with ... Topliss JG, Sherlock MH, Clarke FH, Daly MC, Pettersen BW, Lipski J, Sperber N (1961). "3-Substituted Dihydrobenzothiadiazine 1 ... Butizide is quickly absorbed from the gut with a bioavailability of 85%. It reaches highest blood plasma concentrations after ...
The surface of conventional activated carbon is reactive, capable of oxidation by atmospheric oxygen and oxygen plasma[26][27][ ... Activated is sometimes substituted with active. ... this allows a plasma sample to be analyzed for abnormalities ... Exner, T; Michalopoulos, N; Pearce, J; Xavier, R; Ahuja, M (March 2018). "Simple method for removing DOACs from plasma samples ... "Modification of the surface properties of an activated carbon by oxygen plasma treatment". Fuel. 77 (1): 613-624. doi:10.1016/ ...
H. E. Shannon, E. J. Cone and D. Yousefnejad (1981). "Physiologic effects and plasma kinetics of phenylethanolamine and its N- ... Application to the preparation of β-arylalkylamines and 3-substituted 1,2,3,4-tetrahydroisoquinolines." J. Org. Chem. 49 4107- ... "plasma half-life" of N-methylphenylethanolamine was therefore about 1 hour. In animal tissue, N-methylphenylethanolamine is ... "A one-pot reduction-transimination-reduction synthesis of N-substituted β-ethanolamines from cyanohydrins." Tetrahedron 48 3977 ...
Oils and fats can be hydrogenated to give a diesel substitute. The resulting product is a straight-chain hydrocarbon with a ... "Council Directive 85/536/EEC of 5 December 1985 on crude-oil savings through the use of substitute fuel components in petrol". ... Biochar made from agricultural waste can substitute for wood charcoal. As wood stock becomes scarce, this alternative is ... or converted via the Fischer-Tropsch process to produce a diesel substitute, or a mixture of alcohols that can be blended into ...
Rituximab may be substituted for cyclophosphamide to induce remission since it is similarly effective and has a comparable side ... Plasma exchange is also used in severe cases with damage to the lungs, kidneys, or intestines.[9] ...
To abdicate from the rule of reason and substitute for it an authentication of belief by the intentness and degree of ... Hannes Alfvén (1908-1995): Swedish electrical engineer and plasma physicist. He received the 1970 Nobel Prize in Physics for ...
Plasma gasifierEdit. In a plasma gasifier a high-voltage current is fed to a torch, creating a high-temperature arc. The ... The 32 MW dual fluidized bed gasification of the GoBiGas project in Gothenburg, Sweden, produced around 20 MW of substitute ... "Plasma gasification: Clean renewable fuel through vaporization of waste". www.waste-management-world.com. January 7, 2009. ... "Pyrogenesis Perfecting Plasma - Biomassmagazine.com". biomassmagazine.com. Archived from the original on 2014-10-23. Retrieved ...
The production of a-Si thin film solar cells uses glass as a substrate and deposits a very thin layer of silicon by plasma- ... Due to the difficulty in measuring these parameters directly, other parameters are substituted: thermodynamic efficiency, ... Silicon thin-film cells are mainly deposited by chemical vapor deposition (typically plasma-enhanced, PE-CVD) from silane gas ... are avoided by epitaxial growth of silicon on GaAs at low temperature by plasma-enhanced chemical vapor deposition (PECVD)[66] ...
Also, 'oxygen-carrying substitutes' are emerging. Buffer solutions[edit]. Buffer solutions are used to correct acidosis or ... such as fresh frozen plasma or cryoprecipitate. ... The main blood substitutes used today are volume expanders such ... Further information: Blood product, Blood transfusion, and Blood substitute. A blood product (or blood-based product) is any ... Blood substitutes (also called 'artificial blood' or 'blood surrogates') are artificial substances aiming to provide an ...
Blood or plasma MDPV concentrations are expected to be in a range of 10-50 μg/L in persons using the drug recreationally, >50 ... In the UK, following the ACMD's report on substituted cathinone derivatives, MDPV is a Class B drug under The Misuse of Drugs ... MDPV is the 3,4-methylenedioxy ring-substituted analog of the compound pyrovalerone, developed in the 1960s, which has been ... MDPV may be quantified in blood, plasma or urine by gas chromatography-mass spectrometry or liquid chromatography-mass ...
Plasma arc loudspeakers use electrical plasma as a radiating element. Since plasma has minimal mass, but is charged and ... substitute for such chambers. Some developers eschew anechoic chambers in favor of specific standardized room setups intended ... a tweeter whose plasma was generated from helium gas.[66] This avoided the ozone and nitrous oxide[66] produced by RF ... decomposition of air in an earlier generation of plasma tweeters made by the pioneering DuKane Corporation, who produced the ...
... blood substitutes that carry increased oxygen, hypoxic cell radiosensitizer drugs such as misonidazole and metronidazole, and ...
"Effect of Caloric Restriction on the 24-Hour Plasma DHEAS and Cortisol Profiles of Young and Old Male Rhesus Macaques". Annals ...
"Low plasma levels of adrenocorticotropic hormone in patients with acute influenza" (PDF). Clin Infect Dis. 26 (3): 708-10. doi ... genome and recombinant DNA technology may accelerate the generation of new vaccine strains by allowing scientists to substitute ...
Substitutes larger than diethoxy at the X2-X3 position had decreased activity. The effects of these substitutions seem to be ... leading to 10-100 times lower plasma drug concentration of pomalidomide. Thalidomide and its analogs help with the co- ... Substituted amides that were larger than methylamide (CONHCH3) decrease PDE4 inhibition activity. Using a carboxylic acid as a ... Lenalidomide is synthesized in a similar way using compound 3 (3-aminopiperidine-2,6-dione) treated with a nitro-substituted ...
... which causes blood vessels to dilate and become leaky to plasma proteins. Histamine also causes itchiness by acting on sensory ... Natural food substitutes. *Cheese analogues. *Coffee substitutes. *Egg substitutes. *Meat analogues *bacon ...
Substituted derivativesEdit. Main article: Substituted phenethylamine. Substituted phenethylamines are a chemical class of ... Plasma Pharmacokinetics of PEA Could Be Described By 1st-Order Kinetics With Estimated T/2 of Approx 5-10 Min.. ... The class of substituted phenethylamines includes all substituted amphetamines, and substituted methylenedioxyphenethylamines ( ... All of the substituted amphetamines are phenethylamines as well. Pharmaceutical drugs that are substituted phenethylamines ...
95%) bound to plasma proteins. Terminal half-life is 16 hours; 65% of the substance are found in the urine and 20% in the ... and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets". Biochemical ... faeces, mainly in form of an acetic acid derivative (which is not detectable in the plasma), but also other water-soluble ...
... reaches its maximum concentration (tmax) within 1-2 hours.[9] After a 20 mg dose, plasma concentrations reach ... it is classified as a substituted amphetamine. ...
3) were found to be less hazardous and may be used as a liquid substitute for toxic germane gas in semiconductor applications. ... Plasma and urine germanium concentrations in these individuals, several of whom died, were several orders of magnitude greater ...
Iodine (mmol/L concentration is usually higher than plasma, but dependent variable according to dietary iodine intake) ... Substitutes[edit]. A number of commercially available saliva substitutes exist.[16] See also[edit]. *Spittle cures ...
During plasma donation, the red blood cells are pumped back into the body right away and only the plasma is collected. ... Blood substitute. *Packed red blood cells. *Red blood cell indices. *Serum (blood) ... The blood plasma alone is straw-colored, but the red blood cells change color depending on the state of the hemoglobin: when ... Packed red blood cells, which are made in this way from whole blood with the plasma removed, are used in transfusion medicine.[ ...
1998). "Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart ... Pteridine: Substituted pteridines are intermediates in the biosynthesis of dihydrofolic acid in many microorganisms. ... and plasma vitamin B12 and folate levels. A serum folate of 3 μg/L or lower indicates deficiency.[59] Serum folate level ...
Substitute the equilibrium molarities into the basicity constant K. b. =. 1.8. ×. 10. −. 9. =. x. ×. x. .20. −. x. {\ ... Acid gastric contains a higher concentration of weak base than plasma.[6] Acid urine, compared to alkaline urine, excretes weak ...
Ce, Ga and Nd are important in electronics and are used in the production of LCD and plasma screens, fiber optics, lasers,[88] ... the fact that rare earth elements cannot be substituted by other elements and that REEs have a low recycling rate. Furthermore ...
In Central Australia, the rabbit has become a substitute for native mammals, and during droughts, cattle carcasses provide most ... Catling, PC (1979). "Seasonal variation in plasma testosterone and the testis in captive male dingoes, Canis familiaries dingo ...
... the elimination of latanoprost acid from plasma is rapid (half-life 17 minutes) after either ophthalmic or intravenous ... PF24/Fresh frozen plasma (Cryosupernatant + Cryoprecipitate). Blood substitute. *Hemoglobin-based. Volume expander. *Lactated ...
... the effects of substituting monounsaturated fats or carbohydrates are unclear.[48][49] ... "Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the ...
This type is called plasma exchange (PE, PLEX, or PEX) or plasma exchange therapy (PET). The removed plasma is discarded and ... as well as an annual physical exam with a licensed physician or an approved physician substitute under the supervision of the ... Sometimes the plasma is thawed and transfused as Fresh Frozen Plasma (FFP), much like the plasma from a normal blood donation. ... Octapharma Plasma, Inc. - Plasma donation safety *^ ABEL, J. J.; ROWNTREE, L. G.; TURNER, B. B. (1913). "On the removal of ...
Substituted phenols and derivatives of phenylenediamine are common antioxidants used to inhibit gum formation in gasoline ( ... Teichert J, Preiss R (November 1992). "HPLC-methods for determination of lipoic acid and its reduced form in human plasma". ... water-soluble antioxidants react with oxidants in the cell cytosol and the blood plasma, while lipid-soluble antioxidants ... "Dietary glutathione intake in humans and the relationship between intake and plasma total glutathione level". Nutrition and ...
Substituting the measured values for the Sun and Earth yields: T. S. =. 5778. K. ,. {\displaystyle T_{\rm {S}}=5778\ \mathrm {K ... Prior to this time, most matter in the universe was in the form of an ionized plasma in thermal, though not full thermodynamic ... Substituting the expressions for solar and planet power in equations 1-6 and simplifying yields the estimated temperature of ... law the temperature spectrum of a black body is proportionally related to the frequency of light and one may substitute the ...
A blood plasma substitute may refer to: An artificially made substance designed to have one or more of the vast amount of ... This disambiguation page lists articles associated with the title Blood plasma substitute. If an internal link led you here, ... although providing volume is only one of many functions of blood plasma) ... functions of the contents of the blood plasma Volume expander ( ...
Wide Variation in the In-Vitro Colloid Osmotic Pressure of Plasma Substitutes S.A. Barclay; S.A. Barclay ... S.A. Barclay, E.D. Bennett; Wide Variation in the In-Vitro Colloid Osmotic Pressure of Plasma Substitutes. Clin Sci (Lond) 1 ... Albumin/Globulin Ratios, Colloid Osmotic Pressures and Lowry Protein Microanalysis in Rat Plasma Clin Sci Mol Med (December, ...
Plasma Exchange Effects of different plasma substitutes on blood coagulation: a comparative review. de Jonge E, Levi M ... OBJECTIVE: To compare the effects of different colloid plasma substitutes on blood coagulation and postoperative blood loss. ... Learn more about the need for plasma donors, plasma donation, and how you can save and improve lives. Find a Donation Center. ... Rapidly degradable HES 200/0.5/6 and gelatin-based plasma expanders appear not to impair hemostasis. However, based on the ...
... K- ... The effects of substituting spray-dried whole egg from egg grading plants for spray-dried plasma protein in phase I diets. en_ ... Up to 50% (3.5% of the diet) of spray-dried plasma protein can be replaced with spraydried whole egg (6% of the diet) without ... A study was conducted to evaluate the effects of replacing spray-dried plasma protein with spray-dried whole egg from egg ...
Red cells from normal donors were resuspended in their own plasma diluted with plasma substitutes or saline. The haematocrit wa ... A comparative study of the effects of plasma substitutes on apparent blood viscosity was made at low and high shear rates. ... At clinically relevant plasma dilutions there were very small effects of plasma substitutes on apparent blood viscosity at high ... Red cells from normal donors were resuspended in their own plasma diluted with plasma substitutes or saline. The haematocrit ...
Plasma substitutes[edit]. *Dextran 70[note 67]. Cardiovascular medicines[edit]. Antianginal medicines[edit]. *Bisoprolol[note ... Blood products of human origin and plasma substitutes[edit]. Blood and blood components[edit]. ... 11 Blood products of human origin and plasma substitutes *11.1 Blood and blood components ... Plasma-derived medicines[edit]. Human immunoglobulins[edit]. *Rho(D) immune globulin (anti-D immunoglobulin) ...
... intended for volume replacement ... Substitutes of plasma are the plasma of donor blood (natural plazmozamenitel), dextrans, and salts of electrolytes (solutions ... Substitutes plasma, and other blood components. Analgesics (11) Hematotropics (110) - Antiaggregants (37) - Anticoagulants (25) ... Substitutes plasma, and other blood components used mainly for the treatment and prevention of shock different origins, AD ...
... intended for volume replacement ... Substitutes of plasma are the plasma of donor blood (natural plazmozamenitel), dextrans, and salts of electrolytes (solutions ... Substitutes plasma, and other blood components used mainly for the treatment and prevention of shock different origins, AD ... Plasma-substituting agents (albumin 20-25%, dextrose 20-50% solution) can be used in such situations as preparations for ...
PL-serum, similar to PL-plasma, can substitute for FBS in hMSC cultures. Use of PL-serum, in contrast to PL-plasma, has an ... Platelet lysate-serum (PL-serum) was converted from platelet lysate-plasma (PL-plasma) that was manufactured from pooled ... To address this issue, we investigated the ability of a novel human platelet serum supplement to substitute for FBS in hMSC ... Growth factor levels and the number of residual intact platelets in PL-serum and PL-plasma were compared with enzyme-linked ...
HIV-1 plasma levels ,= 30,000 copies/mL (*)less than 3 months of ART for vertical transmission is considered as ARV therapy ... Safety Study of Once a Day ART and Opiate Substitute. (3OD). This study has been completed. ... detectable plasma HIV-1-RNA levels by reverse transcriptase polymerase chain reaction (RT-PCR). ...
The determination of plasma protein binding (PPB) of a compound is enabled by equilibrium dialysis, an accepted and standard ... NOVEL N-ACYL-(3-SUBSTITUTED)-(8-SUBSTITUTED)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS ... Compounds of Formula I are N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines. The compounds of ... The ring atoms of (3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines of the invention are numbered ...
... can be safely used as blood plasma substitute is not pseudo-science but real science with carefully recorded.... ... Seawater As A Safe Blood Plasma Substitute. The theory that seawater can be used as a safe blood plasma substitute was born at ... of seawater being a safe blood plasma substitute is seawater pollution. No matter where the water is collected and how well it ... "ocean plasma" in a drip bag above my head before the lights went out" rather than any other modern blood agents. Thompson ...
Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos. Lancet. 1971;1(7710):1143-5.CrossRefPubMedGoogle ... Should not be substituted for prescription omega-3 fatty acid products. Dietary supplements are not OTC drugs; no OTC omega-3 ... Distinct regulation of plasma LDL cholesterol by eicosapentaenoic acid and docosahexaenoic acid in high fat diet-fed hamsters: ... At the same time, it is equally important that prescription products containing both DHA and EPA not be substituted for the ...
Substitutes,,Dental,Membranes,and,Tissue,Engineering,2011,medicine,advanced medical technology,medical laboratory technology, ... In 2010 the total European markets for dental bone graft substitutes ...,Reportlinker,Adds,European,Markets,for,Dental,Bone, ... 17.1.3 Platelet Rich Plasma (PRP)... 454. 17.2 MARKET ANALYSIS AND FORECAST 456 ... Substitute Market, Benelux, 2007 - 2017 ... 266. Figure 10-2: Total Dental Bone Graft Substitute and Other Biomaterials Market ...
Substitutes,and,Other,Biomaterials,2011,medicine,advanced medical technology,medical laboratory technology,medical device ... 8.1.3 Platelet Rich Plasma (PRP).. 213. 8.2 MARKET ANALYSIS AND FORECAST 215 ... Substitute Market, South Korea, 2007 - 2017 .. 136. Figure 6-2: Total Dental Bone Graft Substitutes and Other Biomaterials ... Substitute Market, Australia, 2007 - 2017 . 176. Figure 7-2: Total Dental Bone Graft Substitutes and Other Biomaterials Market ...
plasma-to-blood ratio. fu. fraction unbound. EC50,u. EC50based on free drug concentrations. HR. heart rate. MAP. mean arterial ... 8-Alkylamino-Substituted Analogs of N6-Cyclopentyladenosine Are Partial Agonists for the Cardiovascular Adenosine A1 Receptors ... 8-Alkylamino-Substituted Analogs of N6-Cyclopentyladenosine Are Partial Agonists for the Cardiovascular Adenosine A1 Receptors ... 8-Alkylamino-Substituted Analogs of N6-Cyclopentyladenosine Are Partial Agonists for the Cardiovascular Adenosine A1 Receptors ...
Global Gelatin Peptide Plasma Substitute Market Outlook 2021 is a market research report available at US $2900 for a Single ... Global Gelatin Peptide Plasma Substitute Market Outlook 2021. Table of Contents. 1 Gelatin Peptide Plasma Substitute Market ... 1.2 Gelatin Peptide Plasma Substitute Segment by Type. 1.2.1 Global Gelatin Peptide Plasma Substitute Sales Growth Rate ... Global Gelatin Peptide Plasma Substitute Market: Regional Analysis. The Gelatin Peptide Plasma Substitute market is analysed ...
Comparative study of β-tricalcium phosphate mixed with platelet-rich plasma versus β-tricalcium phosphate, a bone substitute ... Comparative study of β-tricalcium phosphate mixed with platelet-rich plasma versus β-tricalcium phosphate, a bone substitute ... Comparative study of β-tricalcium phosphate mixed with platelet-rich plasma versus β-tricalcium phosphate, a bone substitute ... Comparative study of β-tricalcium phosphate mixed with platelet-rich plasma versus β-tricalcium phosphate, a bone substitute ...
The sugar substitute chemicals may not give you the natural spike in blood sugar that sugar does but they do trick your body. ... What are these substitutes for sugar?. Saccharin, Acesulfame Potassium, Aspartame, Sucralose and D-Tagatose are sugar ... substitutes that are used as sweeteners for diabetics. These are available in many different products. ...
Seawater - A Safe Blood Plasma Substitute? Date added:. 01/18/2008. Date modified:. 05/02/2008. ... Diluted seawater contains almost the same concentration of minerals and trace elements as blood plasma, and its sodium content ... It has been used successfully in animal tests as a blood transfusion substitute, but human trials are long overdue. ...
DO PLASMA SUBSTITUTES HAVE ADDITIONAL PROPERTIES BEYOND CORRECTING VOLUME DEFICITS?. Boldt, Joachim ...
Disclosed are new substituted pyrazole and triazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or ... A dose may be formulated in animal models to achieve a circulating plasma concentration range which includes the IC50 (the ... substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, cycloalkyl, substituted ... substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, cycloalkyl, substituted ...
Although it contains no blood components such as red blood cells, white blood cells, platelets or plasma, it removes carbon ... A blood substitute (also called artificial blood or blood surrogates) is a substance used to mimic and function blood. ... The main categories of blood substitutes are hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbon-based oxygen carriers ... Blood Substitute, 978-613-6-65775-2, Please note that the content of this book primarily consists of articles available from ...
Pancreatic elastase is also supplied commercially as areagent for quantitation of α1-antitrypsin in plasma. Plasma α1- ... wherein R12 is pyrrolidine, morpholine, phenyl substituted by CO2R15, oxadiazole substituted by hydroxy, triazole, or tetrazole ... phenyl substituted by CO2R15, oxadiazole substituted by a hydroxy group, or an unsubstituted C-linked tetrazole group; and R15 ... phenyl substituted by CO2R15, oxadiazole substituted by a hydroxy group, or an unsubstituted C-linked tetrazole group; and R15 ...
... it is banned in many industrialized countries and many substitutes are now being commercially used. We studied few of the most ... Samples prepared on polycarbonate filters were analyzed by scanning electron microscopy, x-ray spectrometry, and plasma ... We studied few of the most frequently used substitutes for in vitro cytotoxicity and tested aerosolized dusts within two hours ... This study demonstrates that silica sand blasting substitutes are not without biological effects and in some instances the ...
Plasma Substitutes. Blood Substitutes. To Top. *For Patients and Families. *For Researchers ...
Boldt J, Suttner S. Plasma substitutes. Minerva Anestesiol. 2005 Dec;71(12):741-58. Review. ... Langeron O, Doelberg M, Ang ET, Bonnet F, Capdevila X, Coriat P. Voluven, a lower substituted novel hydroxyethyl starch (HES ... for effective perioperative plasma volume substitution in cardiac surgery. Can J Anaesth. 2000 Dec;47(12):1207-15. ...
... determination of ionic leaching profiles in buffered solution by inductively coupled plasma optical emission spectrometry (ICP- ... treated with dissolution products of different compositions of Nb-substituted glass. The results revealed that Nb-substituted ... Therefore, these results support the assertion that Nb-substituted glass is suitable for biomedical applications. ... investigation of the kinetics of chemical reactivity and the bioactivity of Nb-substituted glass in simulated body fluid (SBF) ...
Plasma expanders and blood substitutes. US6080431 *. Jan 6, 1995. Jun 27, 2000. The Procter & Gamble Company. Combined calcium ... Methods of using plasma expanders and blood substitutes. US6387612. Aug 27, 1999. May 14, 2002. Biotime, Inc.. Method of ... Plasma expanders and blood substitutes. US6576277. Feb 16, 2001. Jun 10, 2003. Welch Foods, Inc.. Calcium-fortified, grape- ... Solutions for use as plasma expanders and substitutes. US6811804 *. May 28, 2002. Nov 2, 2004. Abbott Laboratories. Juice and ...
  • Saccharin, Acesulfame Potassium, Aspartame, Sucralose and D-Tagatose are sugar substitutes that are used as sweeteners for diabetics. (healthwatchcenter.com)
  • Which Sugar Substitutes Are Good for Diabetes? (healthline.com)
  • In fact, the increased consumption of these sugar substitutes may correlate to the increase of obesity and diabetes cases. (healthline.com)
  • In an effort to reduce intake of sugar and calories, many people turn to artificial sweeteners or other sugar substitutes to satiate their cravings for sweets. (crossfitinvictus.com)
  • Rapidly degradable HES 200/0.5/6 and gelatin-based plasma expanders appear not to impair hemostasis. (pptaglobal.org)
  • types of blood substitutes are volume expanders, which include solutions such as saline that are used to replace lost plasma volume, and oxygen therapeutics, which are agents designed to replace oxygen normally carried by hemoglobin in red blood cells. (britannica.com)
  • At Octapharma Plasma you can channel your passion for helping others into a medical career that is fast-paced and personally and professionally rewarding. (aftercollege.com)
  • Effects of different plasma substitutes on blood coagulation: a comparative review. (pptaglobal.org)
  • The synthesized compounds completely generated SN-38 in pH 7.4 buffer or in human plasma, while remaining stable under acidic conditions. (mdpi.com)
  • Effect of a New Class of Compounds of the Group of Substituted 5r1, 6h2-1,3,4-Thiadiazine-2-Amines on the Inflammatory and Cytokine Response in Experimental Myocardial Infarction. (medworm.com)
  • In many processes where previously CFCs were used, these are now being increasingly substituted by fluorinated compounds such as HFCs (which, simply put, are similar substances to CFCs but do not contain chlorine and do not deplete stratospheric ozone). (innovationtoronto.com)
  • Hydroxyethyl starch and dextran substitutes had viscosities ranging from 1.7 to 2.5 times that of plasma whilst gelatins showed viscosities similar to plasma. (iospress.com)
  • This article describes our study of the rheological properties of HbV suspended in a series of plasma substitute solutions of various molecular weights: recombinant human serum albumin (rHSA), dextran (DEX), modified fluid gelatin (MFG), and hydroxylethyl starch (HES). (elsevier.com)
  • A blood plasma substitute may refer to: An artificially made substance designed to have one or more of the vast amount of functions of the contents of the blood plasma Volume expander (although providing volume is only one of many functions of blood plasma) This disambiguation page lists articles associated with the title Blood plasma substitute. (wikipedia.org)
  • OBJECTIVE: To compare the effects of different colloid plasma substitutes on blood coagulation and postoperative blood loss. (pptaglobal.org)
  • A comparative study of the effects of plasma substitutes on apparent blood viscosity was made at low and high shear rates. (iospress.com)
  • At clinically relevant plasma dilutions there were very small effects of plasma substitutes on apparent blood viscosity at high shear rates. (iospress.com)
  • The two solutions which caused least change in apparent blood viscosity compared to no plasma dilution were 3.5% polygeline, a small molecular weight gelatin, and 6% diafiltered hydroxyethyl starch with a degree of substitution of 5 and comparatively narrow range of moderately sized molecules. (iospress.com)
  • Substitutes plasma, and other blood components intended for volume replacement, saving its state of aggregation, the substitution of certain functions of the blood (leukocyte weight, preparations of plasma, thrombocyte concentrate), maintain water and electrolyte balance, oncotic pressure of the blood, correction of acid-base balance. (o-t-c.co.uk)
  • Substitutes of plasma are the plasma of donor blood (natural plazmozamenitel), dextrans, and salts of electrolytes (solutions of crystalloids). (o-t-c.co.uk)
  • Plasma contains all the components of the liquid portion of human blood, but require special methods of storage and care for the donor organism to antigenic relationship. (o-t-c.co.uk)
  • Substitutes plasma, and other blood components used mainly for the treatment and prevention of shock different origins, AD normalization and improvement gemodinamicakih indicators. (o-t-c.co.uk)
  • The theory that seawater can be used as a safe blood plasma substitute was born at the beginning of 1900's, when French naturalist, physiologist and biologist René Quinton (also dubbed the "French Darwin"), who studied the similarity between seawater and blood plasma and the effect of seawater on the health of mammals. (whatisanormalbloodsugarlevel.com)
  • In his experiments on stray dogs (treating them the in best possible way, in fact) Quinton completely replaced their blood with "ocean plasma" - diluted, cold-filtered ocean water. (whatisanormalbloodsugarlevel.com)
  • The therapy was based on the long forgotten in the medical world works of René Quinton, who insisted that the basis of healing any disease is correcting the "internal terrain" or the body - blood plasma by properly balancing the mineral composition by the means of seawater. (whatisanormalbloodsugarlevel.com)
  • However, one of my personal "cons" of seawater being a safe blood plasma substitute is seawater pollution. (whatisanormalbloodsugarlevel.com)
  • The sugar substitute chemicals may not give you the natural spike in blood sugar that sugar does but they do trick your body. (healthwatchcenter.com)
  • A blood substitute (also called artificial blood or blood surrogates) is a substance used to mimic and function blood. (morebooks.de)
  • Although it contains no blood components such as red blood cells, white blood cells, platelets or plasma, it removes carbon dioxide and transfers oxygen throughout the body until bone marrow is capable of producing more red blood cells. (morebooks.de)
  • The main categories of blood substitutes are hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbon-based oxygen carriers (PFBOCs). (morebooks.de)
  • 100 g-1 of blood was removed from the right femoral artery and equal volume of plasma substitute was infused into left femoral vein simultaneously within 5 min. (bvsalud.org)
  • His blood type was B, Rh negative, and his intravascular fluid volume was maintained with balanced salt solution and plasma substitutes, i.e., hydroxyethyl starch. (nih.gov)
  • Extreme hemodilution can be successfully managed by maintaining a normal blood volume, 100% oxygen, and the use of plasma substitutes. (nih.gov)
  • Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. (bioportfolio.com)
  • However scientists are developing chemicals (oxygen therapeutics, or "blood substitutes") which have the same oxygen-carrying capability as blood and can be used as replacements for blood transfusion or to treat diseases where oxygen transport is impaired. (wiley.com)
  • and academia - industry collaboration in blood substitute development. (wiley.com)
  • Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood is an essential reference for clinicians, haematologists, medicinal chemists, biochemists, molecular biologists, biotechnologists and blood substitute researchers. (wiley.com)
  • Therefore health care practitioners must administer 3 volumes of crystalloid for each volume of blood or plasma lost. (popline.org)
  • In addition, the apparatus is adapted to include one or more modules for conditioning the blood, such as modules that include a heat exchanger, blood purifier, plasma and blood cell apheresis device and others. (google.co.uk)
  • He also developed several polymers, including substitutes for chewing gum and human blood plasma. (encyclopedia.com)
  • Keith Perkins has been a plasma donor since 1999 and has donated 19 units of plasma since March to the Arkansas Blood Institute after recovering from covid-19. (arkansasonline.com)
  • And there is no substitute for blood. (arkansasonline.com)
  • Whole blood is drawn and the plasma is separated from the red blood cells. (arkansasonline.com)
  • This research report presents an in-depth analysis of the global blood plasma market by product type, application, end user, and geographic market. (marketresearch.com)
  • In addition, report provides qualitative information related to the mode of delivery for blood plasma. (marketresearch.com)
  • The report includes key blood plasma products used in various therapeutic treatments as well as an examination of the supply chain from research to manufacturing. (marketresearch.com)
  • The report also featu res an in-depth analysis of key companies operating in the global blood plasma market and patents that highlight past, current and projected global technology trends. (marketresearch.com)
  • The blood plasma market is primarily segmented into five major blood plasma components: immunoglobulin, albumin, hyperimmune globulin, coagulation factor concentrates, and other plasma fractionation products. (marketresearch.com)
  • The global blood plasma market is further segmented by application, which helps in understanding the potency of blood plasma products in several therapeutic treatments. (marketresearch.com)
  • In the analysis based on end users, the blood plasma market is segmented as hospitals and clinics, research laboratories, academic institutions and blood transfusion centers. (marketresearch.com)
  • Key regions like the U.S., Canada, Mexico, Europe (U.K., Italy, France, Germany and Spain), China, India and Japan are highlighted in the discussion due to a high concentration of blood plasma products manufacturing companies and contract manufacturing organizations in these areas. (marketresearch.com)
  • Recent products launched by blood plasma products companies are studied and listed in the report. (marketresearch.com)
  • Plasma is the liquid part of the blood. (macmillan.org.uk)
  • Plasma exchange (plasmapheresis) is a way of separating plasma from blood cells using a machine called a cell separator. (macmillan.org.uk)
  • Plasma exchange can reduce the amount of abnormal protein in the blood. (macmillan.org.uk)
  • Plasma exchange is a procedure which separates your blood into its different parts: red cells, white cells, platelets and plasma. (macmillan.org.uk)
  • The plasma is removed from the blood and replaced by a plasma substitute. (macmillan.org.uk)
  • Plasma cells are a type of white blood cell. (macmillan.org.uk)
  • Plasma exchange is done using a machine called a cell separator, which separates blood cells and plasma. (macmillan.org.uk)
  • This spins the blood to separate the plasma from the blood cells so that the plasma can be removed. (macmillan.org.uk)
  • The rest of your blood is then mixed with a plasma substitute and returned to you through the vein in your other arm. (macmillan.org.uk)
  • During plasma exchange, only a small amount (less than 100ml) of blood is outside your body at any time. (macmillan.org.uk)
  • The rate of plasma exchange is decided according to your height, weight and the thickness (viscosity) of your blood. (macmillan.org.uk)
  • The number of plasma exchanges that you need will depend on the amount of protein in your blood, your symptoms and your response to other treatments such as chemotherapy. (macmillan.org.uk)
  • Fasting Plasma Glucose (FPG) - is a blood-glucose test taken after not having anything to eat or drink (except water - even do not drink a lot of water before the test) a minimum of eight hours before the test. (amazonaws.com)
  • The colloid-osmotic effect of human albumin 200 or 250 g/L is approximately 4 times that of blood plasma. (mims.com)
  • We studied few of the most frequently used substitutes for in vitro cytotoxicity and tested aerosolized dusts within two hours of blasting and after aging for four weeks. (cdc.gov)
  • We chemically characterized porcine grafts under low-temperature Argon plasma treatment (CAP) and evaluated their biocompatibility in-vitro. (elsevier.com)
  • Comparison of ATMP gingiva and skin substitutes and their in vitro wound healing potentials. (bioportfolio.com)
  • abstract = "Animal experiments were carried out with osteoconductive bone substitute β-tricalcium phosphate (β-TCP), with the aim of assessing the effects of the growth factors synthesised by thrombocytes on the speed of β-TCP incorporation and on the quality of newly formed bone. (elsevier.com)
  • abstract = "Low-temperature plasma-treated porcine grafts (PGPT) may be an effective means for treating demanding osseous defects and enhance our understanding of plasma-tissue engineering. (elsevier.com)
  • In those circumstances, crystalloid solutions or alternatives such as plasma or albumin, although associated with other serious complications, could be considered. (pptaglobal.org)
  • Plasma-substituting agents (albumin 20-25%, dextrose 20-50% solution) can be used in such situations as preparations for parenteral nutrition (see TOOLS FOR ENTERAL AND PARENTERAL NUTRITION). (o-t-c.co.uk)
  • Albumin and plasma protein fraction make up the 3rd set of substitutes. (popline.org)
  • The transport of fatty acids (FAs) in plasma occurs in two ways: via (albumin-bound) free FAs (FFAs) and via triglycerides (TGs) that are transported in TG-rich lipoproteins. (diabetesjournals.org)
  • Plasma substitutes and plasma protein fractions, albumin. (mims.com)
  • Measures of adequacy of circulating volume and not plasma albumin levels should be used to determine the dose required. (mims.com)
  • Plasma proteins, normally retained within the joint has an extensive reference list for further details. (goodsamatlanta.org)
  • Collectively, the HbV suspension viscosity was influenced by the presence of plasma substitutes. (elsevier.com)
  • The preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor. (bioportfolio.com)
  • However,drawbacks such as donor site complications, high surgical cost, lengthy surgical procedures, and longer recovery time resulted in a shift from allograft bones to other biological alternatives, such as BMP, DBM, and bone substitutes. (digitaljournal.com)
  • Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engine. (bio-medicine.org)
  • The primary outcome was plasma colloid osmotic pressure (COP). (nih.gov)
  • Unlike artificial sweeteners and sugar , stevia can suppress your plasma glucose levels and significantly increase glucose tolerance. (healthline.com)
  • Red cells from normal donors were resuspended in their own plasma diluted with plasma substitutes or saline. (iospress.com)
  • Platelet rich plasma and high volume image guided injections of saline have been used in the treatment of patellar tendinopathy with positive results. (bioportfolio.com)
  • Study was designed to evaluate efficacy of autologous platelet rich plasma (PRP) injections guided by ultrasound for treatment of knee osteoarthritis. (bioportfolio.com)
  • The purpose of the study is to evaluate the efficacy of intra-articular injections of combined hyaluronic acid and platelet-rich plasma in knee degenerative joint disease in terms of impro. (bioportfolio.com)
  • Intra-articular Injections of Platelet-Rich Plasma Releasate Reduce Pain and Synovial Inflammation in a Mouse Model of Osteoarthritis. (bioportfolio.com)
  • Crystalloid, a plasma substitute, spread swiftly from the capillaries into the interstitial fluid space. (popline.org)
  • In this model, TGFAs mix locally at the capillaries with plasma FFAs, where they would lead to an increase in the local FA concentration, and hence, FA uptake. (diabetesjournals.org)
  • Hemorrheological effects of colloidal plasma substitutes infusion. (biomedsearch.com)
  • In plasma exchange the infusion rate should be adjusted to rate of removal. (mims.com)
  • Platelet lysate-serum (PL-serum) was converted from platelet lysate-plasma (PL-plasma) that was manufactured from pooled platelet-rich plasma (PRP) apheresis units. (nih.gov)
  • The question to be answered was the extent to which platelet-rich plasma (PRP) accelerated the resorption of β-TCP and the formation of new bone. (elsevier.com)
  • The purpose of this study is to evaluate the affect that platelet rich plasma has on the molecular an cellular functioning of the knee joint. (bioportfolio.com)
  • Although platelet rich plasma (PRP) and Hyaluronic acid (HA) are beneficial for osteoarthritis of knee (OA knee), the combined effect of PRP with HA was not clear so far. (bioportfolio.com)
  • This study aimed to analyze the effect of platelet-rich plasma (PRP) on knee osteoarthritis. (bioportfolio.com)
  • Platelet rich plasma versus hyaluronic acid in patients with hip osteoarthritis: A meta-analysis of randomized controlled trials. (bioportfolio.com)
  • This study aims to compare the efficacy of intra-articular injection of hyaluronic acid (HA) and platelet-rich plasma (PRP) for treating hip osteoarthritis (OA). (bioportfolio.com)
  • Effect of arthrocentesis plus platelet-rich plasma and platelet-rich plasma alone in the treatment of temporomandibular joint osteoarthritis: A retrospective matched cohort study (A STROBE-compliant article). (bioportfolio.com)
  • Although the research on using platelet-rich plasma (PRP) for temporomandibular joint osteoarthritis (TMJ-OA) has advanced, no unified standards exist for determining the joint use of arthrocentesis a. (bioportfolio.com)
  • Synergistic activity of platelet rich plasma and high volume image guided injection for patellar tendinopathy. (bioportfolio.com)
  • Does leukocyte-poor or leukocyte-rich platelet-rich plasma applied with biopolymers have superiority to conventional platelet-rich plasma applications on chondrocyte proliferation? (bioportfolio.com)
  • This study aims to investigate the possible effects of leukocyte concentration in the content of platelet-rich plasma (PRP) and the administration of PRP using a drug delivery system on chondrocyte pr. (bioportfolio.com)
  • Platelet-rich plasma and the upper extremity. (biomedsearch.com)
  • Autologous Platelet-Rich Plasma/Thrombin Gel Combined with Split-Thickness Skin Graft to Manage Postinfectious Skin Defects: A Randomized Controlled Study. (bioportfolio.com)
  • Another set of substitutes are synthetic colloids which serve to retain circulatory water and volume. (popline.org)
  • A collective grouping for both naturally occurring and synthetic hormones, substitutes, and antagonists. (bioportfolio.com)
  • 11) Monitoring of therapeutic concentrations in plasma can improve safety and efficacy. (who.int)
  • We investigated the relationship between the SN-38G/SN-38 concentration ratio and the dose of CPT-11 in 70 patients with colorectal cancer who received FOLFIRI-based regimens, by measuring the plasma concentrations of CPT-11, SN-38, and SN-38G. (cdc.gov)
  • Efaproxiral can be absorbed via transdermal, rectal, inhalation and gastrointestinal routes, though not at plasma concentrations great enough to alter the oxygen-haemoglobin dissociation curve. (wikipedia.org)
  • In-vivo gentamicin concentrations in plasma and drain fluid after bone defect reconstruction using a gentamicin-eluting bone graft substitute. (perssupport.nl)
  • One trial evaluated the impact of protein substitute versus no protein substitute on neuropsychological status, plasma amino acid concentrations, and nutrient intake. (cochrane.org)
  • The remaining two trials investigated the impact of differing dosages of protein substitute on plasma amino acid concentrations and nutrient intake. (cochrane.org)
  • The plasma fractionation market is largely driven by the growing use of immunoglobulins in various therapeutic areas, increase in plasma collection (and the number of plasma collection centers), and the increasing use of alpha-1-antitrypsin. (marketsandmarkets.com)
  • Skin and oral mucosa substitutes are a therapeutic option for closing hard-to-heal skin and oral wounds. (bioportfolio.com)
  • While these low-calorie or no-calorie substitutes may seem like innocuous sweeteners, they may carry health consequences worse than the table sugar they are meant to replace. (crossfitinvictus.com)
  • We performed a systematic review of randomised control trials investigating the impact of the use, dosage, and distribution of protein substitute on physical and neuropsychological outcomes in the treatment of PKU. (cochrane.org)
  • Currently data are insufficient to reach any conclusions regarding the use, dosage, and distribution of protein substitute in the treatment of PKU. (cochrane.org)
  • Further randomized or controlled clinical trials are needed to provide evidence for the effectiveness, dosage, and distribution of protein substitute in the treatment of PKU. (cochrane.org)
  • Guidance regarding the use, dosage, and distribution of dosage of the protein substitute over a 24-hour period is unclear, and there is variation in recommendations among treatment centres. (cochrane.org)
  • To assess the benefits and adverse effects of protein substitute, its dosage, and distribution of dose in children and adults with phenylketonuria who are adhering to a low-phenylalanine diet. (cochrane.org)
  • One trial investigated the use of protein substitute in 16 participants, while a further two trials investigated the dosage of protein substitute in a total of 53 participants. (cochrane.org)
  • The present invention relates to topical dosage formulations, containing human plasma fibronectin and other wound healing promoters, for use in promoting wound healing in humans. (google.co.uk)
  • Serum-converted platelet lysate can substitute for fetal bovine serum in human mesenchymal stromal cell cultures. (nih.gov)
  • Growth factor levels and the number of residual intact platelets in PL-serum and PL-plasma were compared with enzyme-linked immunosorbent assays and flow cytometry, respectively. (nih.gov)
  • Proliferation responses of hMSCs cultured in PL-serum, PL-plasma, or FBS were assessed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, the immunophenotype of harvested hMSCs was evaluated by flow cytometry and tri-lineage differentiation potential was evaluated by assessing adipogenic, osteogenic and chondrogenic development. (nih.gov)
  • hMSC cultures supplemented with PL-serum had comparable growth kinetics to PL-plasma, and hMSC yields were consistently greater than with FBS. (nih.gov)
  • hMSCs harvested from cultures supplemented with PL-serum, PL-plasma or FBS had similar cell surface phenotypes and maintained tri-lineage differentiation potential. (nih.gov)
  • PL-serum, similar to PL-plasma, can substitute for FBS in hMSC cultures. (nih.gov)
  • Use of PL-serum, in contrast to PL-plasma, has an added advantage of not requiring addition of a xenogeneic source of heparin, providing a completely xeno-free culture medium. (nih.gov)
  • Expiration date: 08/2021 Action:plasma replacementComposition:AlbuminIndications:shock /traumat. (o-t-c.co.uk)
  • Human fibrinogen contains the soluble constituent of human plasma that is transformed to fibrin on the addition of thrombin. (drugs.com)
  • Therefore, HbV must be suspended in or co-injected with an aqueous solution of a plasma substitute (water-soluble polymer), which might interact with HbV. (elsevier.com)
  • A preparation consisting of PLATELETS concentrated in a limited volume of PLASMA. (bioportfolio.com)
  • Food BEVERAGES that are used as nutritional substitutes for MILK. (bioportfolio.com)
  • Other research has found that substituting diet beverages for sugar-sweetened beverages to be ineffective for reducing weight [8,9]. (crossfitinvictus.com)
  • Samples prepared on polycarbonate filters were analyzed by scanning electron microscopy, x-ray spectrometry, and plasma emission spectrometry. (cdc.gov)
  • People with phenylketonuria (PKU) who follow a low-phenylalanine diet are required to take protein substitute to ensure adequate consumption of protein, energy, and other nutrients. (cochrane.org)
  • A strong, porous article useful as a bone substitute material. (google.ca)
  • OBJECTIVES: I. Determine the safety and efficacy of biosynthetic skin substitute as a routine therapy for treatment of severe burn injuries. (bioportfolio.com)
  • Plasma transfusions are generally safe and tolerated well by most patients, but the therapy has not been tested for effectiveness against COVID-19. (utmb.edu)
  • However, the FDA has recently allowed for the "emergency use" of COVID-19 convalescent plasma as an investigational therapy. (utmb.edu)
  • This study demonstrates that silica sand blasting substitutes are not without biological effects and in some instances the cytotoxicity exceeds that of sand and may provoke lung injury. (cdc.gov)
  • In February 2018, Guizhou Taibang Biological Products Co. Ltd., a wholly-owned subsidiary of China Biologic Products Organization, received approval from the Hainan Provincial Health and Family Planning Commission to build a new plasma collection station in Hainan Province. (marketsandmarkets.com)
  • The characteristic form of plasma fibronectin is a disulfide-bonded dimer of 440,000 daltons, each subunit having a molecular weight of about 220,000 daltons. (google.co.uk)
  • North America is expected to dominate the plasma fractionation market during the forecast period. (marketsandmarkets.com)
  • The larger volume of distribution at steady state of the 8-substituted analogs resulted in terminal half-lives (ranging from 17 to 24 min) which were significantly longer than for CPA (7 min). (aspetjournals.org)
  • Sedation, cognitive slowing, and hypotension from lowered plasma volume to ml/kg. (nrha.org)