Plasma: The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.Plasma Cells: Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Plasma Gases: Ionized gases, consisting of free electrons and ionized atoms or molecules which collectively behave differently than gas, solid, or liquid. Plasma gases are used in biomedical fields in surface modification; biological decontamination; dentistry (e.g., PLASMA ARC DENTAL CURING LIGHTS); and in other treatments (e.g., ARGON PLASMA COAGULATION).Plasma Volume: Volume of PLASMA in the circulation. It is usually measured by INDICATOR DILUTION TECHNIQUES.Plasma Exchange: Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Blood Glucose: Glucose in blood.TriglyceridesPlatelet-Rich Plasma: A preparation consisting of PLATELETS concentrated in a limited volume of PLASMA. This is used in various surgical tissue regeneration procedures where the GROWTH FACTORS in the platelets enhance wound healing and regeneration.Lipoproteins: Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Insulin: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).Radioimmunoassay: Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.Reference Values: The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Leukemia, Plasma Cell: A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. It can be a primary manifestation of multiple myeloma or develop as a terminal complication during the disease.Homocysteine: A thiol-containing amino acid formed by a demethylation of METHIONINE.Area Under Curve: A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)Biological Transport: The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.Semen: The thick, yellowish-white, viscid fluid secretion of male reproductive organs discharged upon ejaculation. In addition to reproductive organ secretions, it contains SPERMATOZOA and their nutrient plasma.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Renin: A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Metabolic Clearance Rate: Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.Fasting: Abstaining from all food.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Lipoproteins, HDL: A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Hydrocortisone: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.Fatty Acids, Nonesterified: FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. These fatty acids are not in glycerol ester form.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Cross-Over Studies: Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Plasma Membrane Calcium-Transporting ATPases: Calcium-transporting ATPases found on the PLASMA MEMBRANE that catalyze the active transport of CALCIUM from the CYTOPLASM into the extracellular space. They play a role in maintaining a CALCIUM gradient across plasma membrane.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Injections, Intravenous: Injections made into a vein for therapeutic or experimental purposes.Apolipoproteins: Protein components on the surface of LIPOPROTEINS. They form a layer surrounding the hydrophobic lipid core. There are several classes of apolipoproteins with each playing a different role in lipid transport and LIPID METABOLISM. These proteins are synthesized mainly in the LIVER and the INTESTINES.Protein Transport: The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Osmolar Concentration: The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Lipoproteins, LDL: A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.Retinol-Binding Proteins, Plasma: Retinol binding proteins that circulate in the PLASMA. They are members of the lipocalin family of proteins and play a role in the transport of RETINOL from the LIVER to the peripheral tissues. The proteins are usually found in association with TRANSTHYRETIN.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Lipoproteins, VLDL: A class of lipoproteins of very light (0.93-1.006 g/ml) large size (30-80 nm) particles with a core composed mainly of TRIGLYCERIDES and a surface monolayer of PHOSPHOLIPIDS and CHOLESTEROL into which are imbedded the apolipoproteins B, E, and C. VLDL facilitates the transport of endogenously made triglycerides to extrahepatic tissues. As triglycerides and Apo C are removed, VLDL is converted to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LOW-DENSITY LIPOPROTEINS from which cholesterol is delivered to the extrahepatic tissues.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Cholesterol, HDL: Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.Sheep: Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.Apolipoprotein A-I: The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.Blood Chemical Analysis: An examination of chemicals in the blood.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Infusions, Intravenous: The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.Dietary Fats: Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.Plasma Substitutes: Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.Blood Coagulation: The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Aldosterone: A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.Neoplasms, Plasma Cell: Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Plasma Kallikrein: A peptidohydrolytic enzyme that is formed from PREKALLIKREIN by FACTOR XIIA. It activates FACTOR XII; FACTOR VII; and PLASMINOGEN. It is selective for both ARGININE and to a lesser extent LYSINE bonds. EC 3.4.21.34.Apolipoproteins B: Major structural proteins of triacylglycerol-rich LIPOPROTEINS. There are two forms, apolipoprotein B-100 and apolipoprotein B-48, both derived from a single gene. ApoB-100 expressed in the liver is found in low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). ApoB-48 expressed in the intestine is found in CHYLOMICRONS. They are important in the biosynthesis, transport, and metabolism of triacylglycerol-rich lipoproteins. Plasma Apo-B levels are high in atherosclerotic patients but non-detectable in ABETALIPOPROTEINEMIA.Hematocrit: The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.Endocytosis: Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Chromatography, Liquid: Chromatographic techniques in which the mobile phase is a liquid.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Cell Fractionation: Techniques to partition various components of the cell into SUBCELLULAR FRACTIONS.Norepinephrine: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Molecular Weight: The sum of the weight of all the atoms in a molecule.Random Allocation: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.Atrial Natriuretic Factor: A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.Apolipoproteins A: Structural proteins of the alpha-lipoproteins (HIGH DENSITY LIPOPROTEINS), including APOLIPOPROTEIN A-I and APOLIPOPROTEIN A-II. They can modulate the activity of LECITHIN CHOLESTEROL ACYLTRANSFERASE. These apolipoproteins are low in atherosclerotic patients. They are either absent or present in extremely low plasma concentration in TANGIER DISEASE.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Pregnancy-Associated Plasma Protein-A: A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.Blood Specimen Collection: The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Cholesterol, LDL: Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.Mice, Inbred C57BLSeminal Plasma Proteins: Proteins found in SEMEN. Major seminal plasma proteins are secretory proteins from the male sex accessory glands, such as the SEMINAL VESICLES and the PROSTATE. They include the seminal vesicle-specific antigen, an ejaculate clotting protein; and the PROSTATE-SPECIFIC ANTIGEN, a protease and an esterase.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Cholesterol Esters: Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Glucagon: A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)Eating: The consumption of edible substances.Tandem Mass Spectrometry: A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.Postprandial Period: The time frame after a meal or FOOD INTAKE.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Adipose Tissue: Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Heparin: A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.Apolipoproteins E: A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.Hyperlipidemias: Conditions with excess LIPIDS in the blood.Infusions, Parenteral: The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.Carotenoids: The general name for a group of fat-soluble pigments found in green, yellow, and leafy vegetables, and yellow fruits. They are aliphatic hydrocarbons consisting of a polyisoprene backbone.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Corticosterone: An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)Dietary Supplements: Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.Fibrinolysis: The natural enzymatic dissolution of FIBRIN.Folic Acid: A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.Subcellular Fractions: Components of a cell produced by various separation techniques which, though they disrupt the delicate anatomy of a cell, preserve the structure and physiology of its functioning constituents for biochemical and ultrastructural analysis. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p163)Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Catecholamines: A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Intestinal Absorption: Uptake of substances through the lining of the INTESTINES.Progesterone: The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Cholesterol, Dietary: Cholesterol present in food, especially in animal products.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Potassium: An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.Kallikreins: Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifically, Kallikreins are potent vasodilators and hypotensives and increase vascular permeability and affect smooth muscle. They act as infertility agents in men. Three forms are recognized, PLASMA KALLIKREIN (EC 3.4.21.34), TISSUE KALLIKREIN (EC 3.4.21.35), and PROSTATE-SPECIFIC ANTIGEN (EC 3.4.21.77).Hormones: Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.Vitamin B 12: A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.Blood Coagulation Tests: Laboratory tests for evaluating the individual's clotting mechanism.Methods: A series of steps taken in order to conduct research.von Willebrand Factor: A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.Growth Hormone: A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Golgi Apparatus: A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)Leptin: A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.Exocytosis: Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.Chromatography, Gel: Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Absorption: The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Urea: A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.HIV-1: The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.Luteinizing Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.Blood Coagulation Factors: Endogenous substances, usually proteins, that are involved in the blood coagulation process.Zinc: A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.Arginine: An essential amino acid that is physiologically active in the L-form.Viral Load: The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).Microscopy, Confocal: A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.Membrane Lipids: Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.CreatinineMultiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Lipoprotein Lipase: An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 3.1.1.34.Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Interleukin-6: A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.Solubility: The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Phosphatidylcholine-Sterol O-Acyltransferase: An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. EC 2.3.1.43.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.C-Reactive Protein: A plasma protein that circulates in increased amounts during inflammation and after tissue damage.Calibration: Determination, by measurement or comparison with a standard, of the correct value of each scale reading on a meter or other measuring instrument; or determination of the settings of a control device that correspond to particular values of voltage, current, frequency or other output.Blood Viscosity: The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.Drug Stability: The chemical and physical integrity of a pharmaceutical product.alpha-Macroglobulins: Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.Obesity: A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.Estradiol: The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.

The induction of macrophage spreading: role of coagulation factors and the complement system. (1/1906)

Unstimulated mouse peritoneal macrophages, attached to either glass or plastic substrates, responded to factors generated in serum and plasma by spreading and increasing their apparent surface area up to eightfold. Two distinct and dissociable systems were involved. The first appears related to the distinct and dissociable systems were involved. The first appears related to the contact phase of blood coagulation. It is activated by glass and not plastic surfaces, depleted by kaolin adsorption, and inhibited by soybean trypsin inhibitor. In contrast, a separate complement-dependent system can be generated in kaolin-adsorbed plasma. Activation of the complement system can occur either by the alternate or classical pathways and generates a relatively small effector molecule which is dialyzable. These factors presumably influencing the surface membrane and underlying structures may explain the rapid spreading of activated macrophages observed after both infections and chemical peritoneal inflammatory agents.  (+info)

Effects and interactions of opioids on plasma exudation induced by cigarette smoke in guinea pig bronchi. (2/1906)

The effects of opioids on cigarette smoke-induced plasma exudation were investigated in vivo in the main bronchi of anesthetized guinea pigs, with Evans blue dye as a plasma marker. Acute inhalation of cigarette smoke increased plasma exudation by 216% above air control values. Morphine, 0.1-10 mg/kg but not 30 mg/kg, inhibited the exudation but had no significant effect on substance P-induced exudation. Both 10 and 30 mg/kg of morphine increased exudation in air control animals, an effect inhibited by antihistamines but not by a tachykinin neurokinin type 1-receptor antagonist. Naloxone inhibited all morphine responses. Cigarette smoke-induced plasma exudation was inhibited by a mu-opioid-receptor agonist (DAMGO) but not by agonists at delta (DPDPE)- or kappa (U-50488H)-receptors. None of these agonists affected exudation in air control animals. DPDPE prevented the inhibition by DAMGO of cigarette smoke-induced plasma exudation, and the combination of DAMGO and DPDPE increased exudation in air control animals. Prevention of inhibition and the combination-induced increase were inhibited by antihistamines or the mast cell-stabilizing drug sodium cromoglycate. U-50488H did not alter the response to either DAMGO or DPDPE. We conclude that, in guinea pig main bronchi in vivo, mu-opioid-receptor agonists inhibit cigarette smoke-induced plasma exudation via a prejunctional mechanism. Plasma exudation induced by mu- and delta-receptor interactions is due to endogenous histamine release from mast cells.  (+info)

Kinin B1 receptor antagonists containing alpha-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities. (3/1906)

-To protect from metabolism and to improve potency of the AcLys-[D-betaNal7,Ile8]desArg9-bradykinin (BK) (R 715), we prepared and tested 3 analogues containing alpha-methyl-L-Phe ([alphaMe]Phe) in position 5: these are the AcLys-[(alphaMe)Phe5,D-betaNal7, Ile8]desArg9BK (R 892), Lys-Lys-[(alphaMe)Phe5,D-betaNal7, Ile8]desArg9BK (R 913), and AcLys-Lys-[(alphaMe)Phe5,D-betaNal7, Ile8]desArg9BK (R 914). The new compounds were tested against the contractile effect induced by desArg9BK on 2 B1 receptor bioassays, the human umbilical vein, and the rabbit aorta. Their antagonistic activities were compared with those of the early prototypes (Lys-[Leu8]desArg9BK and [Leu8]desArg9BK) and with other recently described peptide antagonists. The 3 (alphaMe)Phe analogues showed high antagonistic potencies (pA2) at both the human (8.8, 7.7, and 8. 7, respectively) and rabbit (8.6, 7.8, and 8.6, respectively) B1 receptors. No antagonistic effects (pA2<5) were observed on the B2 receptors that mediate the contractile effects of BK on the human umbilical vein, the rabbit jugular vein, and the guinea pig ileum. Moreover, these new B1 antagonists were found to be resistant to in vitro degradation by purified angiotensin-converting enzyme from rabbit lung. The Nalpha-acetylated forms, R 892 and R 914, were resistant to aminopeptidases from human plasma. In vivo antagonistic potencies (ID50) of B1 receptor antagonists were evaluated in anesthetized lipopolysaccharide-treated (for B1 receptor) and nontreated (for B2 receptor) rabbits against the hypotensive effects of exogenous desArg9BK and BK. R 892 efficiently inhibited (ID50 2.8 nmol/kg IV) hypotension induced by desArg9BK without affecting that evoked by BK (ID50 >600 nmol/kg IV). Conversely, the peptide antagonists Lys-Lys-[Hyp3,Igl5,D-Igl7,Oic8]desArg9BK (B 9858) and DArg-[Hyp3,Thi5,D-Tic7,Oic8] desArg9BK (S 0765) showed dual B1/B2 receptor antagonism in vitro and in vivo. It is concluded that R 892 and congeners provide selective, highly potent, and metabolically stable B1 kinin receptor antagonists that can be useful for the assessment of the physiological and pathological roles of kinin B1 receptors.  (+info)

Inhibitory effect of plasma obtained from hypophysectomized and control women on the assay of bioactive luteinizing hormone. (4/1906)

The purpose of this study was to determine the effect of components of female plasma on the value of bioactive luteinizing hormone (LH), especially in the presence of low immunological LH value. Using both an immunoradiometric assay (IRMA) and rat Leydig cell bioassay, immunoreactive (I) and bioactive (B) LH were assessed in plasma collected from women during a gonadotrophin releasing hormone (GnRH) test performed on day 7 of a spontaneous cycle. Two modes of response to an acute administration of GnRH were defined: normal production of gonadotrophins (group I) and excessive secretion (group II) associated with a significant difference in the B/I-LH ratio between the two groups. The B/I-LH ratio did not vary with sampling time during the test in either group. The addition of LH-free plasma collected from hypophysectomized women caused a 30% decrease in testosterone production compared to control values (in the presence or absence of hLH standard). A partial restoration of testosterone production was observed if plasma was first treated with PEG 12%. The inhibitory factor(s) was also present in plasma from ovulatory women, even after treatment by an antibody against the entire LH molecule. The effect of normal (A) or low I-LH plasma (B) on testosterone production varied strongly according to the plasma volume added to the bioassay, as well as to plasma treatments. Diethylether treatment caused a 50% decrease in testosterone secretion for plasma B (but not for A) whereas a diminution of the steroidogenesis is observed after a PEG treatment of plasma A (but not for B), suggesting that different inhibitory factors are present in plasmas A and B. Therefore the LH bioactivity measured in the rat Leydig cell assay, in terms of testosterone output, seems to represent a balance between the LH molecule and the presence of inhibitory factors in the plasma.  (+info)

Absence in amphotericin B-spiked human plasma of the free monomeric drug, as detected by SERS. (5/1906)

Using surface enhanced Raman spectroscopy (SERS) which enables us to specifically detect traces of monomeric amphotericin B (AmB), we were able to show that in a 10(-5) M AmB suspension, the concentration of free drug was below 10(-8) M in the presence of low density lipoproteins (LDL) or plasma. The affinity constant of AmB for LDL determined from electronic absorption data, was found to be 4 x 10(6) M(-1). Therefore, since AmB appears to be in the majority bound to lipoproteins under in vivo conditions, its toxicity should not result from the induction of host-cell transmembrane permeability but rather from the internalization of the AmB-LDL complex.  (+info)

NH2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity. (6/1906)

Gastric inhibitory polypeptide (GIP) is an important insulin-releasing hormone of the enteroinsular axis that, like glucagon-like peptide 1(7-36) amide (tGLP-1), has a functional profile of possible therapeutic value for type 2 diabetes. Both incretin hormones are rapidly inactivated in plasma by the exopeptidase dipeptidyl peptidase (DPP) IV. The present study examined the ability of NH2-terminal modification of human GIP to protect from plasma degradation and enhance insulin-releasing and antihyperglycemic activity. Degradation of GIP by incubation at 37 degrees C with purified DPP IV was clearly evident after 4 h (54% intact). After 12 h, >60% of GIP was converted to GIP(3-42), whereas >99% of NH2-terminally modified Tyr1-glucitol GIP remained intact. Tyr1-glucitol GIP was similarly resistant to serum degradation. The formation of GIP(3-42) was almost completely abolished by inhibition of plasma DPP IV with diprotin A. Effects of GIP and Tyr1-glucitol GIP were examined in Wistar rats after intraperitoneal injection of either peptide (10 nmol/kg) together with glucose (18 mmol/kg). Plasma glucose concentrations were significantly lower and insulin concentrations higher after both peptides compared with glucose alone. More importantly, individual glucose values at 15 and 30 min together with the areas under the curve (AUCs) for glucose were significantly lower after administration of Tyr1-glucitol GIP compared with GIP (AUC 255 +/- 33 vs. 368 +/- 8 mmol x l(-1) x min(-1), respectively; P < 0.01). This was associated with a significantly greater and more protracted insulin response after Tyr1-glucitol GIP than GIP (AUC 773 +/- 41 vs. 639 +/- 39 ng x ml(-1) x min(-1); P < 0.05). These data demonstrate that Tyr1-glucitol GIP displays resistance to plasma DPP IV degradation and exhibits enhanced antihyperglycemic activity and insulin-releasing action in vivo.  (+info)

Suppression of lymphocyte transformation by plasma from owl monkeys acutely infected with Plasmodium falciparum. (7/1906)

Plasma collected from owl monkeys during the acute phase of Plasmodium falciparum infection was shown to adversely affect several in vitro responses which are considered to be correlates of cell-mediated immune functions of normal monkeys. In the presence of acute-phase plasma, response of normal monkey peripheral blood lymphocytes to stimulation with phytohemagglutinin, concanavalin A, and pokeweed mitogen was severely reduced, as was the ability of peripheral blood lymphocytes to respond to allogenic and xenogenic histocompatible antigens. The transformation response of peripheral blood lymphocytes from normal humans to phytohemagglutinin and concanavalin A was also suppressed. Since acute-phase plasma was not cytotoxic for peripheral blood lymphocytes, decreased responsiveness did not result from cell destruction. Acute-phase plasma appears to block initial steps in lymphocyte transformation.  (+info)

Modeling the effects of proteins on pH in plasma. (8/1906)

Stewart's model of plasma acid-base balance (Can. J. Physiol. Pharmacol. 61: 1444-1461, 1983) has three weaknesses in the treatment of weak acids: 1) the combination of all weak acids into one entity, 2) inappropriate chemistry for the protein combination with H+, and 3) undocumented values for the dissociation parameters. The present study models serum albumin acid-base properties by fixed negative charges and the association of H+ with the imidazole side chain of histidine. This model has three parameters: 1) the net negative fixed charge (21 eq/mol), 2) the number of histidine residues (16/mol), and 3) the association constant for the imidazole side chain (1.77 x 10(-7) eq/l), all determined from published values. The model was compared with that of Figge, Mydosh, and Fencl (J. Lab. Clin. Med. 120: 713-719, 1992) and with the pH data of Figge, Rossing, and Fencl (J. Lab. Clin. Med. 117: 453-467, 1991). The predictions of pH were excellent, comparable to those found by Figge, Mydosh, and Fencl. The model has the advantages that its structure and parameter values are supported by the literature and that the acid-base effects of factors modifying protein can be investigated.  (+info)

*Postprandial glucose test

Glucose levels in a blood sample taken from the vein (called a blood plasma value) may differ a little from glucose levels ... "Standards of Medical Care-Table 6 and Table 7, Correlation between A1C level and Mean Plasma Glucose Levels on Multiple Testing ... The American Diabetes Association recommends a postprandial glucose level under 140mg/dl and a preprandial plasma glucose ...

*Platelet-rich plasma

... (PRP) is a concentrate of platelet-rich plasma protein derived from whole blood, centrifuged to remove red ... As a concentrated source of blood plasma and autologous conditioned plasma, PRP contains several different growth factors and ... Platelet-rich plasma is used in horses for treatment of equine lameness due to tendon and ligament injury, wounds, fractures, ... platelet-rich plasma evidence Results by year graph, PubMed.gov, National Center for Biotechnology Information, U.S. National ...

*Dielectric barrier discharge

The plasma is generated on top of the surface of an SDBD plate. A particular compact and economic DBD plasma generator can be ... The plasma itself is used to modify or clean (plasma cleaning) surfaces of materials (e.g. polymers, semiconductor surfaces), ... the biomedical applications of plasmas. This field is now known as plasma medicine. An additional process when using chlorine ... "Sterilization of contaminated matter with an atmospheric pressure plasma", IEEE Trans. Plasma Sci. 24, 1188 (1996) "Dielectric ...

*Cardiac marker

suPARnostic is a prognostic test used to detect suPAR levels in blood plasma. Depending on the marker, it can take between 2 ... suPAR concentration positively correlates to the activation level of the immune system and is present in plasma, urine, blood, ...

*Autologous conditioned plasma

... (ACP) is a platelet-rich plasma that is extracted from autologous blood using centrifugation. It ... ACP is a platelet-rich plasma (PRP). PRP is a general term for a type of plasma that contains an increased concentration of ... Autologous Conditioned Plasma (ACP) is an autologous blood plasma ‒ occurring naturally within the body ‒ that is conditioned ... Unlike other platelet-rich plasma formulations, ACP is distinguished by a low concentration of white blood cells such as ...

*Platelet-poor plasma

... (PPP) is blood plasma with very low number of platelets (< 10 X 103/μL). Traditionally, PPP was ... Aliquots with visible red cells or hemolysis (pink plasma) are not acceptable. Freeze plasma immediately. Samples for most ... "Platelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma ... remove the top 3/4 of plasma and place it in a plastic centrifuge tube with cap. Centrifuge the plasma (in the plastic ...

*Lipid profile

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ...

*Plasma

... application of plasma in ignition of fuels Plasma smelting, smelting of metals using plasma Quark-gluon plasma, an extremely ... Plasma (album), a 2003 live album by Trey Anastasio Plasma (comics), a fictional character in the Marvel Universe Plasma ... Plasma arc welding, joining of metals by coalescence using plasma arc as a heat source with or without filler metal Plasma ... Plasma or plasm may refer to: Plasma (physics), an ionized state of matter similar to a gas. Common applications include the ...

*Plasma activation

... (or Plasma functionalization) is a method of surface modification employing plasma processing, which improves ... Many types of plasmas can be used for surface activation. However, due to economic reasons, atmospheric pressure plasmas found ... One of them also acts as a gas nozzle producing a stream of plasma. After the plasma stream leaves the arc region, the ions ... flame treatment and various types of plasma activation. Advantage of the plasma activation lies in its ability to achieve all ...

*Plasma Economy

The selling of blood plasma were seen by locals as a method to reduce poverty. In plasmapheresis, blood plasma is taken from ... 2006 China's Plasma Economy 05-02 16:04 Caijing Magazine Danger of AIDS hidden in a large number of plasma stations in Guizhou ... although demand for blood plasma still remained strong. The impact of the Plasma Economy campaign had a long-lasting effect. It ... The Plasma Economy campaign boomed due to demand by biotech companies, and became a lucrative source of income for middlemen. ...

*Plasma modeling

... refers to solving equations of motion that describe the state of a plasma. It is generally coupled with ... The kinetic model is the most fundamental way to describe a plasma, resultantly producing a distribution function f ( x → , v ... ISBN 0-911302-58-1. Ledvina, S. A.; Y.-J. Ma; E. Kallio (2008). "Modeling and Simulating Flowing Plasmas and Related Phenomena ... There are several main types of plasma models: single particle, kinetic, fluid, hybrid kinetic/fluid, gyrokinetic and as system ...

*Plasma Records

... www.in.com/music/label-listing/plasma-records-791-1.html Plasma Records MySpace Music Page Plasma Records on Facebook Official ... Plasma Records) is a global music label. It was formed in 2000 by Manmohan Waris, Kamal Heer and Sangtar. Plasma Records is the ... Plasma Records most recent releases are Jinday Ni Jinday by Kamal Heer and Dil Te Na Laeen by Manmohan Waris. Plasma Records ... Plasma Records first release, Kamli by Kamal Heer, released in 2000. Since the formation of Plasma Records, Kamal Heer, ...

*Plasma stealth

... but plasma interaction with microwaves is a well explored area of general plasma physics. Standard plasma physics reference ... 2011, a plasma actuator system is used to camouflage weapon bay on a fighter when it is open. In US 8,016,247 B2, the plasma ... A plasma can, at least in principle, absorb all the energy in an incoming wave, and this is the key to plasma stealth. However ... 2011, a plasma generating device is used to create a plasma flow on the trailing edge, which can change its RCS. In US ...

*Anisothermal plasma

The term nonthermal plasma includes anisothermal plasmas and means that the different degrees of freedom of the plasma are not ... An Anisothermal plasma is a plasma which thermal state can be approximated by more than one temperature for the different ... Examples of anisothermal plasmas can be found among low-pressure plasmas that are excited by high frequency electric fields, ... see frequency classification of plasmas. They generally exhibit hot electrons that are powered by the alternating electric ...

*Plasma-lyte

... 148 is a market specific solution available in the United Kingdom and Australia, among others and has the following ... Plasma-Lyte is a crystalloid solution for intravenous infusion with varying electrolyte formulation depending on market. ... Generally the solution has a composition that mimics human physiological plasma electrolyte concentrations, osmolality and pH. ... Plasma-Lyte 148 product information. 2013. available at URL: http://www.baxterhealthcare.com.au/downloads/healthcare_ ...

*Plasma (engine)

"Plasma Engine". giantbomb.com. "Myst Online - Uru - Live". mystonline.com. "CyanWorlds.com Engine". openuru.org. "Plasma The ... Plasma is a real-time 3D game engine originally called Headspin and developed by Headspin Technologies in 1997 and later by ... aka Plasma engine 2.0, the engine used to power Myst Online: Uru Live. realMyst (2000) Uru: Ages Beyond Myst (2003) Uru: To ... github.com/H-uru/Plasma/blob/master/LICENSE.txt " ...

*Plasma channel

A plasma channel is a conductive channel of plasma. A plasma channel can be formed in these ways: With a high-powered laser ... see plasma pinch) due to magnetic forces stemming from the current flowing through the plasma. On Earth plasma channels are ... or form a plasma, such as in a Laser-Induced Plasma Channel, for example in an electrolaser. With a voltage higher than the ... A plasma channel has a low electrical resistance and, once formed, will permit continuous current flow if the energy source ...

*Dusty plasma

... dusty plasmas are also known as complex plasmas. Dusty plasmas are encountered in: Industrial processing plasmas Space plasmas ... Dusty plasmas are often studied in laboratory setups. The dust particles can be grown inside the plasma, or microparticles can ... A dusty plasma is a plasma containing millimeter (10−3) to nanometer (10−9) sized particles suspended in it. Dust particles are ... Padma Kant Shukla-coauthor of Introduction to Dusty Plasma Physics Mendis, D. A. (September 1979). "Dust in cosmic plasma ...

*Plasma kallikrein

... at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology portal ... Plasma kallikrein (EC 3.4.21.34, serum kallikrein, kininogenin, kallikrein I, kallikrein II, kininogenase, kallikrein, ... Kallikrein Heimark, R.L.; Davie, E.W. (1981). "Bovine and human plasma prekallikrein". Methods Enzymol. 80: 157-172. doi: ... plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates". Biochemistry. ...

*Plasma diffusion

The plasma diffusion across the magnetic field is an important topic in magnetic confinement of fusion plasma. It is especially ... 3/2 diffusion in magnetized plasma". Physics of Plasmas. 20 (6): 062302. Bibcode:2013PhPl...20f2302H. doi:10.1063/1.4811472. ... The Hsu diffusion predicts the 1/B3/2 scaling, that is presumably the best confinement scenario in magnetized plasma. Physics ... concerning how the plasma transport is reduced by the strength of the external magnetic field. The classical diffusion gives ...

*Plasma actuator

Plasma has been introduced to hypersonic flow control. Firstly, plasma could be much easier generated for hypersonic vehicle at ... Plasma actuators are a type of actuator currently being developed for aerodynamic flow control. Plasma actuators impart force ... One preliminary roll control system with DBD plasma actuators is shown in the figure. It can be seen that plasma actuators ... The present research of plasma actuators is mainly focused on three directions: (1) various designs of plasma actuators; (2) ...

*Plasma (comics)

Plasma meets her end when the train crashes at a high rate of speed.[volume & issue needed] Plasma at the Appendix to the ... Moon Knight and Ghost Rider attack Plasma. Plasma vaporizes Ghost Rider, who later reforms. In the meantime, Moon Knight takes ... A well-placed plasma blast traps many innocent victims inside. Mr. Parnell, one of the attendees of a homeless benefit held at ... Plasma is a fictional character in the Marvel Universe. Leila O'Toole was born in Dublin, Ireland. As a college student, Leila ...

*Plasma (physics)

Plasmas utilized in "plasma technology" ("technological plasmas") are usually cold plasmas in the sense that only a small ... Under laboratory conditions, dusty plasmas are also called complex plasmas. Impermeable plasma is a type of thermal plasma ... Three factors define a plasma: The plasma approximation: The plasma approximation applies when the plasma parameter, Λ, ... When this criterion is satisfied, the plasma is quasineutral. Plasma frequency: The electron plasma frequency (measuring plasma ...

*Plasma (album)

Plasma is Trey Anastasio's first live album. The two-disc set features live tracks recorded during Trey's summer and fall tour ... Plasma was released on April 29, 2003. "Curlew's Call" - 11:23 (Anastasio/Herman/Marshall) Recorded 10/24/02, Portland ... Exposition Building, Portland, Maine "Plasma" - 4:20 (Anastasio/Herman/Marshall) Recorded 6/9/02, Tower City Amphitheatre, ...

*Ohmic plasma

An ohmic plasma is a plasma that is maintained and/or replenished by the heat produced when a plasma current flows through its ... Heating the plasma-RESEARCH FOR TOMORROW'S ENERGY SUPPLY Poloidal Field Institute for Plasma Physics (IPP-Max Plank) - Ohmic ... "Plasma Confinement at JET". Plasma Physics and Controlled Fusion. 58.1. Spitzer, Lyman; Seeger, Raymond (1963). "Physics of ... Efficiency decreases as the plasma temperature increases. The mechanism is similar to the heat created with an electric current ...
BACKGROUND: Infants and children undergoing cardiopulmonary bypass become substantially hemodiluted secondary to the volume used to prime the oxygenator. Fresh-frozen plasma has been included in the prime to lessen dilution of clotting factors and correspondingly minimize blood loss and transfusions. METHODS: We prospectively randomized 56 patients weighing 10 kg or less who required cardiopulmonary bypass to receive either one unit of fresh-frozen plasma or 200 mL of albumin 5% in the prime. After protamine administration, samples for prothrombin time, fibrinogen, platelet count, and thromboelastogram were obtained. Mediastinal chest tube drainage and transfusion requirements were documented. RESULTS: There were no significant differences between groups regarding demographic or surgical characteristics. Blood loss during the first 24 hours was similar in both groups, but total transfusions were significantly greater in those who received fresh-frozen plasma instead of albumin 5% in the prime ...
Thirty patients with various types of chronic liver disease and a prothrombin time prolonged for four or more seconds who required needle liver biopsy for diagnostic purposes were given either fresh frozen plasma or a concentrate of clotting factors as a prophylactic measure. The prothrombin time returned to within normal limits in seven of the 15 patients given the concentrate and in three of those receiving fresh frozen plasma. Levels of factors II, IX, and X showed increases of about 30% following concentrate administration; corresponding rises in the group given fresh frozen plasma were less. This was because of the smaller quantity of clotting factors administered with fresh frozen plasma and the increase in factor II and IX activity/kg body weight/unit of clotting factor injected was greater when fresh frozen plasma was used. In neither group was there clinical evidence of bleeding, but it was of interest that most of the clotting factor levels, except in factor II, before biopsy were ...
Genomic DNA sequences in cell-free plasma are biomarkers of cancer prognosis, where characteristic changes in methylation of tumour suppressor or oncogene DNA regions are indicative of changes in gene activity. Also, cell-free fetal DNA can be distinguished, by its methylation status, from the maternal DNA in the plasma of pregnant women, hence providing DNA biomarkers for the proposed minimally-invasive diagnosis of fetal aneuploidies, including Downs syndrome. However, the production and clearance of cell-free DNA from plasma in relation to its methylation status, are poorly understood processes.. ...
A plasma-based cell-free DNA test identified mutations in the estrogen receptor 1 gene (ESR1) in 30% of patients from the BOLERO-2 trial of everolimus (Afinitor) plus exemestane, and these mutations were correlated with survival. The results, which support the use of plasma as a source of prognostic-and perhaps predictive-information, were reported at the 2015 San Antonio Breast Cancer Symposium by Sarat Chandarlapaty, MD, of Memorial Sloan Kettering Cancer Center, New York.1. "Using a simple blood test, we found that the D538G and Y537S mutations in the estrogen receptor are more common in patients with advanced, estrogen receptor-positive breast cancer than previously appreciated," Dr. -Chandarlapaty revealed.. The findings were met with enthusiasm by researchers interested in correlative studies of clinical trials, including 2016 President-Elect of ASCO Daniel Hayes, MD. "These trials were started before we recognized the importance of plasma DNA, so Im pretty certain these samples were not ...
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German cancer diagnostics firm Signature Diagnostics has developed a plasma-based ultradeep sequencing test to monitor colorectal cancer patients and detect metastasis early.
Fresh Frozen Plasma (FFP) may be associated with high rates of inappropriate transfusion with some studies indicating rates of up to 50 per cent non-compliance with established guidelines. The current British Committee for Standards in Haematology (BCSH) guidelines on the use of FFP aim to reinforce the message regarding avoidance of its inappropriate use. An audit of FFP use in 2007 in the South Central region, revealed that FFP was used for warfarin reversal in 26 per cent of the cases audited. FFP weight related dosage was poorly implemented with weight being recorded in only 32 per cent of cases. The 2009 National Comparative Audit (NCA) programme indicated that FFP continued to be used for warfarin reversal and, was frequently given where there was no evidence of actual bleeding. An audit of FFP use in the South West in one large hospital, found that following a period of intensive educational measures, appropriate use of FFP improved dramatically, particularly with respect to use for ...
This first-in-human Phase I, single-center, dose escalation study (using 3 dose levels) is proposed to assess the safety of infusing reconstituted lyophilized human plasma (LyP). The study design incorporates plasmapheresis-derived autologous plasma (FFP) for infusion(s) to eliminate variables and events known to be related to allogenic transfusion. Subjects will be enrolled at a blood center and provide autologous FFP that will be shipped to the sponsor site and used as the starting material to manufacture LyP. Once manufacturing is complete, the LyP (autologous) will be returned to the blood center for reconstitution and infusion into subjects. Maximum dosage within this study will approach massive transfusion (1 liter in Cohort 3) to obtain a preliminary assessment of safety. One half of the FFP obtained from subjects in Cohort 3 (only) will be shipped to the sponsor and returned to the site (but not manufactured into LyP) to serve as the control (autologous FFP ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thesis, English, Pharmaceutical Studies of interations Between Certain Anti Inflammatory Drugs And plasma Components Or Their Substitutes for Mohammed Shaimaa El Housiny Younis
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
A commentary in CMAJ (Canadian Medical Association Journal) states that large amounts of frozen plasma are being used inappropriately.
Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,000 different proteins from about 500 gene products. Sigma-Aldrich has been isolating and purifying plasma and blood derived proteins for more than 40 years. As an original manufacturer, we offer the worlds largest portfolio of proteins for research applications. Many of these proteins are produced on a large-scale custom basis under GMP for our manufacturing customers. For more extensive information on individual products and additional technical resources on plasma and blood related proteins and enzymes visit the Enzyme Explorer at sigma-aldrich.com/enzymeexplorer.. ...
A method for isolating tissue repair promoting substances from human or animal blood, which method comprises collecting the human or animal blood from a single human or animal individual in a first container of a container system comprising at least first and second interconnected containers; centrifuging the container system containing said blood so as to separate the blood in various fractions including a plasma fraction; transferring at least part of the plasma fraction to said second container of the container system; subjecting the plasma fraction in said second container to a low temperature so as to obtain a precipitate comprising tissue repair promoting substances; concentrating said precipitate in said second container so as to obtain a first fraction comprising a major part of the non-precipitated material, and a second fraction comprising at least the major part of the precipitate and a minor part of the non-precipitated material; and separating said second fraction comprising the tissue
Don, Actually, to convert TO Plasma-calibrated from whole-blood calibrated, you multiple your whole-blood value by 1.12. If you want to convert plasma- calibrated TO whole-blood, then divide your plasma value by 1.12. Hope that helps. Ryan ,Go for the Plasma values, Both values are correct!!! BUT plasma will ,corralate better with your laboratory results. Most of the older ,meters are set for whole blood, some can be reset to plasma. The newer ,meters are now set for the standard Plasma levels. " that is why you ,hear people upset because their new meters read higher " ,I believe to calculate your whole blood results to plasma, just multiply ,the whole blood by 1.5 , Lifescan.com has a nice article on the ,plasma/whole blood issue. , ,don ---------------------------------------------------------- for HELP or to subscribe/unsubscribe, contact: [email protected] ...
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In this study, we investigated the plasma of cancer patients and detected, in agreement with previous research, concentrations of DNA that are on the average much higher than the DNA levels in the plasma of healthy controls (1, 2, 3, 4) . The range of DNA levels in the circulation of cancer patients varies widely, from levels like those in some of the controls (10-20 ng/ml) to levels that exceed values of 1000 ng DNA/ml plasma. The levels of plasma DNA show no obvious correlation to the type of cancer or to the clinical status. The variations in the amount of total DNA in patients with a similar clinical status were also found in studies of other laboratories with different tumor types (1 , 2 , 13) and could possibly be influenced by differences in the catabolism of plasma DNA in different patients. The difference between the levels of plasma DNA in healthy individuals and cancer patients is more extreme than the results of other studies (1, 2, 3, 4 , 7) . Our explanation for this finding is ...
The confinement in JET baseline type I ELMy H-mode plasmas is compared to that in so-called hybrid H-modes in a database study of 112 plasmas in JET with the carbon fibre composite (CFC) wall. The baseline plasmas typically have βN ∼ 1.5-2, H98 ∼ 1, whereas the hybrid plasmas have βN ∼ 2.5-3, H98 < 1.5. The database study contains both low- (δ ∼ 0.2-0.25) and high-triangularity (δ ∼ 0.4) hybrid and baseline H-mode plasmas from the last JET operational campaigns in the CFC wall from the period 2008-2009. Based on a detailed confinement study of the global as well as the pedestal and core confinement, there is no evidence that the hybrid and baseline plasmas form separate confinement groups; it emerges that the transition between the two scenarios is of a gradual kind rather than demonstrating a bifurcation in the confinement. The elevated confinement enhancement factor H98 in the hybrid plasmas may possibly be explained by the density dependence in the τ98 scaling as n0.41 and ...
A dielectric resonator is excited at its natural resonant frequency to produce a highly uniform electric field for the generation of plasma. The plasma may be used in a optical or mass spectrometer.
The Sample Handling Laboratory in the Cancer and Haematology Centre, Churchill Hospital, Oxford processes patient samples from cancer clinical trials. The role of the postholder is to take receipt of and process clinical samples according to defined laboratory protocols. This will involve several techniques including centrifugation of blood samples, separation of plasma/serum and also of white cells for analysis at other laboratories.
INTRODUCTION. Pharmacokinetics (PK) is the science that studies the time-course of a drug journey in the body of patients. The efficacy of a drug is typically correlated to the administered dose and the concentrations achieved at the site of therapeutic action. Concentrations in plasma are often adequate markers of these and therefore may be related to the observed drug action, biological effect or clinical response. The objective of pharmacokinetics is usually to study the phenomena of drug absorption, distribution, and elimination (metabolism and excretion) in order to develop models that allow predicting the concentration of drugs in plasma sometime after its administration. Given the predictive nature of pharmacokinetics, its language is one of mathematics. This is usually the first and foremost obstacle for its practical use in the clinical setting. However, dosage regimens can be easily adjusted to adapt to changing clinical scenarios without the need of heavy mathematical knowledge. ...
Plasma is the liquid component of blood, in which the red blood cells, white blood cells, and platelets are suspended. Plasma is mostly made up of water around 90-92% this helps with the transport of blood cells around the body, as it can flow easily. Plasma also contains dissolved salts (electrolytes) and proteins; it is a yellow coloured fluid that carries all blood cells ...
How to pronounce plasma in English. The definition of plasma is: the colorless watery fluid of the blood and lymph that contains no cells, but in which the...
How is Plasma Spraying (welding) abbreviated? PSP stands for Plasma Spraying (welding). PSP is defined as Plasma Spraying (welding) somewhat frequently.
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Time-course of the mean plasma con-centration of OPB-51602 after single administration (a) and multiple administrations on day 28 (b). Plasma concentrations bel
Global Plasma Fractionation Industry The report provides a comprehensive analysis of the Plasma Fractionation industry market by types, applications, playe
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PK950 HDTVs have been dubbed as the best LG plasma TV sets ever. They offer extensive features and come at an attractive price. But do they deliver the performance of a flagship model from a top brand?
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I Frozen Plasma sono un gruppo musicale Synthpop/Futurepop Tedesco. Felix Marc Vasi Vallis (EN) Frozen Plasma, su Discogs, Zink Media. (EN) Frozen Plasma, su MusicBrainz, MetaBrainz Foundation ...
Since human plasma can contain viruses, products made from plasma are treated to remove or destroy any viruses that might be present. Plasma products made today have an excellent safety record.1. Octapharma has high standards for its plasma collection centers. Collection centers, donors, and donated plasma are carefully selected and monitored. Octapharma requires all plasma donors to have a US social security number. Every plasma donor undergoes an extensive medical exam before being allowed to donate. All donated plasma undergoes individual unit testing for evidence of a wide variety of viruses (including HIV and hepatitis B and C). Any plasma found to contain these viruses is not used ...
Retraction note: Effect of platelet-rich plasma on the healing of cutaneous defects exposed to acute to chronic wounds: a clinico-histopathologic study in rabbits. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Treatment failure is a key challenge in the management of HIV-1 infection. We conducted a mixed-model survey of plasma nevirapine (NVP) concentrations (cNVP) and viral load in order to examine associations with treatment and adherence outcomes among Kenyan patients on prolonged antiretroviral therapy (ART). Blood plasma was collected at 1, 4 and 24 hours post-ART dosing from 58 subjects receiving NVP-containing ART and used to determine cNVP and viral load (VL). Median duration of treatment was 42 (range, 12-156) months, and 25 (43.1%) of the patients had virologic failure (VF). cNVP was significantly lower for VF than non- VF at 1hr (mean, 2,111ng/ml vs. 3,432ng/ml, p = 0.003) and at 4hr (mean 1,625ng/ml vs. 3,999ng/ml, p = 0.001) but not at 24hr post-ART dosing. Up to 53.4%, 24.1% and 22.4% of the subjects had good, fair and poor adherence respectively. cNVP levels peaked and were | = 3μg.ml at 4 hours in a majority of patients with good adherence and those without VF. Using a threshold of 3μg/ml
In the present work we have evaluated the effect of decreasing concentrations of normal plasma in TC 199 on leukocyte capillary migration. From the 1st to the 4th hour of migration, normal plasma at 100%-80%-60%-40% concentration, significantly inhibits leukocyte migration. The inhibitory effect is lost, only by a few plasmas, at 60% and 40% concentration, during the following migration hours. Normal plasma at 20% and 10% concentration doesnt show any inhibitory effect on leukocyte capillary migration. Therefore, for clinical studies on pathological plasmas we recommend the use o plasma at 20% or 10% concentration to avoid aspecific inhibition.
In the market of High Intensity Discharge (HID) lamps there is a gradual shift from traditional high-pressure plasma light sources based on single-metal emitters (e.g. high pressure sodium and high pressure mercury lamps) towards high-pressure plasma light sources with multiple plasma components. In the last group especially metal-halide lamps with improved energy efficiency and light-technical properties are becoming increasingly important. Since these plasmas are more complex in terms of the plasma chemistry and physics, an improved understanding is needed. In this article a model will be presented for the energy balance of metal-halide lamps. The model includes several submodels, including radiation models for optically thick and optically thin radiation, 2-D radiation transport, a model for the chemical equilibrium reactions between the different components in the plasma, heat conductivity and electrical conductivity, and a 1-D numerical solution of the Elenbaas-Heller equation. As an ...
TY - JOUR. T1 - Modulators of the multidrug-transporter, P-glycoprotein, exist in the human plasma. AU - Ichikawa, Misako. AU - Yoshimura, Akihiko. AU - Furukawa, Tatsuhiko. AU - Sumizawa, Tomoyuki. AU - Akiyama, Shin ichi. PY - 1990/1/15. Y1 - 1990/1/15. N2 - P-glycoprotein (P-gp) is thought to mediate the transport of anticancer drugs and to be responsible for the multidrug-resistant (MDR) phenotype. P-gp is also expressed in normal human tissues, such as the adrenal gland, kidney, liver, colon and capillary endothelium of the brain. However, the function and transporting substrates of P-gp in normal tissues are still not understood. This paper explains that some compounds in the human plasma can modulate the transporting activity of P-gp. A partially purified fraction from the human plasma enhanced the accumulation of anti-cancer agents in MDR cells. This fraction inhibited the efflux of vinblastine from MDR cells, and also inhibited the photoaffinity labeling of P-gp with azidopine as ...
What is plasma lift?. Plasma lift method activates skin cells by application of own plasma. Plasma biomaterial contains unique combination of highly effective substances - growth factors, thrombocytes, leukocyte and stem cells. They activate new cell production and regenerate damaged cells. They work as „building material" for „cell repair".. How does RegenPlasma ACR differ from typical Plasma lift?. In both cases plasma is derived from patients own blood. However, Swiss technology RegenPlazma ACR preserves up to 90% thrombocytes active, other plasma only 40%. High content of active thrombocytes in plasma is essential for cell growth, therefore, results of plasma therapy RegenPlasma ACR are long lasting.. How many treatments are needed?. 2 to 3 treatments, 14 to 20 days apart. The result is visible after 2 - 3 weeks and lasts 8 - 12 months depending on the skin type, skin health and life style.. How do acid hyaluronic fillers differ from plasma?. Plasma gel is no substitute for acid ...
What is plasma lift?. Plasma lift method activates skin cells by application of own plasma. Plasma biomaterial contains unique combination of highly effective substances - growth factors, thrombocytes, leukocyte and stem cells. They activate new cell production and regenerate damaged cells. They work as „building material" for „cell repair".. How does RegenPlasma ACR differ from typical Plasma lift?. In both cases plasma is derived from patients own blood. However, Swiss technology RegenPlazma ACR preserves up to 90% thrombocytes active, other plasma only 40%. High content of active thrombocytes in plasma is essential for cell growth, therefore, results of plasma therapy RegenPlasma ACR are long lasting.. How many treatments are needed?. 2 to 3 treatments, 14 to 20 days apart. The result is visible after 2 - 3 weeks and lasts 8 - 12 months depending on the skin type, skin health and life style.. How do acid hyaluronic fillers differ from plasma?. Plasma gel is no substitute for acid ...
To the Editor:. We were surprised to read the article by Blake et al1 on the relationship of soluble CD40 ligand (sCD40L) and lipid accumulation in carotid atheroma. We recently reported an association between inflammatory markers and early onset carotid atherosclerosis.2 Of the patients noted in that report, we had plasma samples from EDTA-anticoagulated blood, stored frozen for 1 to 3 years. Although the product information and manual of the Bender MedSystems ELISA kit clearly states that plasma preparations are not suitable for the essay,3 we decided to run a test on some of these plasma samples for sCD40L. We also used duplicate plasma samples, together with fresh serum and plasma of 5 healthy subjects obtained less than 4 hours before the ELISA test, in the same ELISA plate. We were not surprised but were disappointed, as no activity could be detected either in the frozen plasma samples of patients or in the fresh or recalcified plasma samples of the healthy subjects. The method and the ...
Plasma DNA was found to be more sensitive than CEA for detecting cancer that cannot be removed through a surgical procedure (100 percent versus 40 percent) and was also more sensitive than CEA in detecting recurrent esophageal cancer (100 percent versus 33 percent). All patients with recurrent disease had elevated plasma DNA, and no patient with normal plasma DNA had recurrent disease (i.e., there were no false positives or false negatives for plasma DNA). Plasma DNA rose before there was clinical evidence of recurrence in 67 percent of patients, versus 17 percent of patients measured for CEA ...
Science Daily has an interesting article up concerning the lifelike qualities of some inorganics caught in a plasma field: Until now, physicists assumed that there could be little organisation in such a cloud of particles. However, Tsytovich and his colleagues demonstrated, using a computer model of molecular dynamics, that particles in a plasma can undergo…
Identification of molecular signatures of cystic fibrosis disease status with plasma-based functional genomics. (Levy H, Jia S, Pan A, Zhang X, Kaldunski M, Nugent ML, Reske M, Feliciano RA, Quintero D, Renda MM, Woods KJ, Murkowski K, Johnson K, Verbsky J, Dasu T, Ideozu JE, McColley S, Quasney MW, Dahmer MK, Avner E, Farrell PM, Cannon CL, Jacob H, Simpson PM, Hessner MJ) Physiol Genomics 2019 01 01;51(1):27-41 PMID: 30540547 PMCID: PMC6383551 SCOPUS ID: 2-s2.0-85060056850 12/13/2018 5 Citations ...
A plasma enhance chemical processing reactor and method. The reactor includes a plasma chamber and a source of electromagnetic energy. The plasma chamber is in communication with a process chamber which includes a wager support and a gas manifold. The plasma generated in the plasma chamber extends into the process chamber and interacts with the reactive gases to deposit a layer of material on the wafer. The reactor also includes a vacuum system for exhausting the reactor. The method includes the steps of generating a plasma within the plasma chamber, introducing at least one gaseous chemical into the process chamber proximate to the wafer support and applying r.f. gradient to induce diffusion of the plasma to the area proximate the wafer support.
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An improved plasma vessel (i.e., plasma applicator) that provides effective cooling includes a plurality of generally linear tubes having a dielectric interior fluidly connected together by dielectric connectors. The tubes and connectors are joined together to form a leak-tight plasma vessel. A cooling system surrounding the improved plasma vessel includes a rigid cooling plate and a deformable thermal transfer material disposed between the plasma vessel and the cooling plate. After use or at an operators discretion, the plasma vessel can be removed from the cooling system and a new vessel may be inserted in its place. Alternatively, the used vessel may be refurbished and re-inserted into the cooling system. The new or refurbished vessel may or may not be of the same size or configuration as the used vessel. Thermal contact between the cooling system and the new or refurbished vessel, however is maintained through the deformable thermal transfer material.
A method and apparatus for continuously sampling plasma are disclosed. The method of the present invention comprises removing blood from the patient, separating a substantially small portion of plasma, and returning the blood to the patient. The removing, separating, and returning steps are performed continuously and simultaneously with each other. The apparatus of the present invention relates to a double-lumen cannula or venipuncture needle for the removal and returning of blood to the patient at the same site.
KEDPLASMA USA, one of the worlds leading collectors of high-quality human blood plasma, has announced the acquisition of two additional plasma collec
Plasma-derived vesicles hold a promising potential for use in biomedical applications. Two major challenges, however, hinder their implementation into translational tools: (a) the incomplete characterization of the protein composition of plasma-derived vesicles, in the size range of exosomes, as mass spectrometric
Up to ten (10) 600 µL aliquots of plasma are stored in 0.5 mL microcentrifuge tubes. Up to five (5) 600 µL aliquots of serum are stored in 0.5 mL microcentrifuge tubes. All the aliquots per sample are placed in a Bitran Saranex Bag and labeled with the sample ID ...
Vitellogenin concentrations in plasma are typically detected using enzyme linked Immunosorbent assay (ELISA; e.g., (Korte et al. 2000; Tyler et al. 1996; Holbech et al. 2001; Fenske et al. 2001). Although less specific and/or sensitive, determination of alkaline-labile phosphate or Western blotting has also been employed.. ...
Average salaries for Biolife Plasma Services Pct: $12. Biolife Plasma Services hourly pay trends based on salaries posted anonymously by Biolife Plasma Services employees.
Plasma Salaries trends. 3 salaries for 2 jobs at Plasma in Carrollton. Salaries posted anonymously by Plasma employees in Carrollton.
HP PE4200N Plasma TV My HP PE4200N Plasma TV has sound but not picture. Its cables and all are plugged in - HP PE4200N 42 in. EDTV Plasma question
By weight, plasma proteins are the most abundant dissolved substances solutes in plasma. These proteins remain in the blood and interstitial fluids and
We cut heavy plate with precision and remarkable speed. Double cutter heads for both gas and plasma as well as double supporting tables for plate, offer large capacity. The choice between gas cutting and plasma cutting is determined by material, quality, thickness and tolerances required. ...
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Learn how to use a plasma torch and angle grinder. This class teaches free hand plasma cutting to create artistic burnt metal designs. Leave the class with your own work of art!
Phoronix: OpenSUSE 42.2 Beta 3 Ships With KDE Plasma 5.8 Just one day after KDE Plasma 5.8 LTS was released, openSUSE Leap 42.2 Beta 3 is shipping and uses
PDP5016H AKAI Plasma TV Need Main Board for this AKAI PDP5016H TV E7801-056002 cant find it anywhere, can it be - Pioneer PDP5016HD 50 in. Plasma question
, Rat Plasma - 500mL, GTX73283, Applications: Blocking, ELISA, ICC/IF, IHC, WB; Blocking, ELISA, Immunocytochemistry/ Immunofluorescence (ICC/IF), Immunohistochemistry (IHC), Western Blot (WB); CrossReactivity:
Find a clinical trial for Plasma Products and sign up to take part. Get links to all you need to know about clinical trials and other useful resources.
Read this and Learn about the 6 major differences between plasma and serum. Learn about the differences other then clotting factors as well...
PECVD / Plasma Coating - Our chemists provide guaranteed solutions and we supply the equipment to meet each deposition application. Video available on website.
Doctors aren’t exactly sure why plasma works, but it’s shown to be so promising when it comes to healing and rejuvenating tissue that they are experimenting with this so-called liquid gold...
Hey AMS I was just checking out your site and the Proto Plasma looks like an awesome and very practical product. I am very interested in it and was
Hello everyone, I have recently install opensuse LEAP 42.1 and I have installed package for my nvidia carte graphique with yast. When I reboot my systeme Plasma 5 has been crashed in launch. I dont know what is the problem all Ive got is this screenshot (https://drive.google.com/file/d/0B9w4y7IH-nnhMUFoQnZZY1VZODQ/view?usp=sharing) So could you please help me? thank you very much.
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article{kroupp:2011a, author = {Kroupp, E. and Osin, D. and Starobinets, A. and Fisher, V. and Bernshtam, V. and Weingarten, L. and Maron, Y. and Uschmann, I. and Forster, E. and Fisher, A. and Cuneo, M. E. and Deeney, C. and Giuliani, J. L ...
article{zastrau:2010a, author = {U.~Zastrau and P.~Audebert and V.~Bernshtam and E.~Brambrink and T.~K{a}mpfer and E.~Kroupp and R.~Loetzsch and Y.~Maron and Yu.~Ralchenko and H.~Reinholz and G.~R{o}pke and A.~Sengebusch and E.~Stambulchik and I.~Uschmann and L.~Weingarten and E.~F{o}rster ...
플라스마를 이용한 반도체 공정에서 End Point의 검출 또는 플라스마의 상태를 관리하기 위한, 발광 분석 방식의 End Point 모니터입니다.신개발된 알고리즘"Rupture Intensity"에 의해 미약한 신호 변화로부터 정확하게 End Point를 검출할 수 있습니다.미약한 신호 변화를 파악할 수 있는, 높은 감도와 노이즈에 강한 내구성으로, 24시간 가동하는 제조 라인의 가혹한 환경에서도 안정된.... ...
Transfusion of blood and blood products is a potentially life-saving measure, but is not without risk.1 Fresh-frozen plasma (FFP) is produced from a single whole-blood donor unit, or through plasmapheresis.2 Despite the lack of cellular components in FFP, complications may follow transfusion. These include allergic reactions, transfusion-related acute lung injury (TRALI), haemolysis, fluid overload and infectious complications.3 Therefore, FFP transfusion should be restricted to cases where its clinical benefit has been established.1. Despite available guidelines on appropriate indications,2 there is increasing worldwide use of FFP transfusion4 with inappropriate indications,5 particularly in tertiary healthcare settings.4 We evaluated the utilisation of FFP and the prescription practices of attending clinicians in a South African tertiary hospital.. Materials and methods. All patients who received FFP transfusions from February to April 2010 at the Steve Biko Academic Hospital were included. ...
A system for preparing autologous plasma comprises a single use filter unit having two inlets in fluid communication with each other, an outlet, and a filtration membrane selectively permeable to blood plasma separating the inlets from the outlet. Manually operable, single use pumps, preferably syringes, connect to the inlets. A flow path is defined along the membrane between the pumps, whereby, whole blood can be repeatedly exchanged between the two pumps, past the membrane, to cause plasma to flow across the membrane and out of the outlet. A syringe can collect plasma from the outlet. Plasma thus collected can be simultaneously applied with a thrombin solution to a site on the body, thereby forming a fibrin gel.
Porcine monocyte-derived macrophages (moMΦ) have been employed as a model cell in numerous studies of the porcine immune system. However, the lack of a standardized method for moMΦ differentiation hampers the comparison of results coming from the use of different laboratory protocols. In this study we compared the use of varying concentrations of autologous plasma (10, 20 and 30% v/v) or recombinant human macrophage-colony stimulating factor (hM-CSF; 50, 100, and 200 ng/ml) to differentiate porcine monocytes into macrophages. Changes in cell morphology and surface marker expression were assessed by confocal microscopy and flow cytometry. Macrophage differentiation was evaluated by analysing TNF-α response to LPS stimulation and determining cytokine secretion patterns under both basal conditions and after classical and alternative activation. The effects of the differentiation methods on metabolic activity and susceptibility to infection with the myelotropic African swine fever virus (ASFV) ...
© 2017 The Cochrane Collaboration. This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effect of different prophylactic plasma transfusion regimens prior to insertion of a lumbar puncture needle or epidural catheter in people with abnormal coagulation.
As noted in Chapter 1, when a tube of anticoagulated blood sediments in a gravitational field, the relatively dense red cells go to the bottom, and the less dense white cells and platelets form a "buffy coat" layer on the upper surface of the red cells, whereas cell-free plasma is least dense and collects at the top of the tube. In the blood bank, the bag of freshly collected donor blood is first centrifuged at relatively low speed, allowing separation into packed red cells and platelet-rich plasma (Fig. 25-1). The platelet-rich plasma is then spun at a higher speed, enabling separation into cell-free plasma and a platelet concentrate (Fig. 25-1). ...
Plasma known as the fourth state of matter is partially or completely ionized gas including a mixture of electrons, ions, radicals, and energetic photons, which is typically generated under high temperature conditions. Due to the interdisciplinary effort of physics and biotechnology, recent technological progress in atmospheric plasmas has led to the creation of cold plasmas with an ion temperature close to the room temperature, which can be controlled or changed according to the desired applications. Moreover, that plasma can interact with organic materials without causing thermal damage to the cell surface, and can effectively inactivate different kinds of pathogens without adversely affecting the healthy tissues. Many other biological applications have also been explored. Accumulated evidence has shown that plasma can be generated and play an increasingly important role in various applications at room temperature, such as blood coagulation, wound healing, and tissue and device sterilization ...
Department of Plastic and Reconstructive Surgery, Kansai Medical University, Osaka, Japan. [email protected] BACKGROUND: This study evaluated changes in platelet-derived growth factor (PDGF)-AB and transforming growth factor (TGF)-beta1 release from platelets by platelet-rich plasma activation, and the proliferation potential of activated platelet-rich plasma and platelet-poor plasma on human adipose-derived stem cells and human dermal fibroblasts. METHODS: Platelet-rich plasma was prepared using a double-spin method, with the number of platelets counted in each preparation stage. Platelet-rich and platelet-poor plasma were activated with autologous thrombin and calcium chloride, and levels of platelet-released PDGF-AB and TGF-beta1 were determined by enzyme-linked immunosorbent assay. Cells were cultured for 1, 4, or 7 days in serum-free Dulbeccos Modified Eagle Medium supplemented with 5% whole blood plasma, nonactivated platelet-rich plasma, nonactivated platelet-poor plasma, ...
Information on the management of casualties from the ongoing conflicts in Afghanistan and Iraq has brought in to question the traditional approach to blood transfusion in hemorrhaging patients. Present recommendations for when to transfuse plasma products is when coagulation tests become abnormal. The proposed trial will investigate whether the more aggressive plasma transfusion strategies as advocated from researchers based on the Central Asian conflicts is valid. Since a study to determine the full impact of an altered plasma transfusion practice would require thousands of patients, a feasibility trial is appropriate and is being proposed. The hypotheses are thus:. Primary Hypothesis- A multicentre trial that investigates the earlier use of plasma in patients with hemorrhagic shock going for emergency surgery will be feasible.. Secondary Hypotheses- The early use of a universal donor blood plasma (AB+ plasma) in patients with shock due to blood loss (i.e. hemorrhagic) going for emergency ...
Plasma exchange, also known as plasmapheresis, is the process of taking blood out of the body, removing constituents in the bloods plasma thought to be harmful, and then transfusing the rest of the blood (mainly red blood cells) mixed with replacement plasma back into the body. Plasma is the liquid part of blood. The solid parts are white and red blood cells. In plasma exchange, blood is drawn from the person. The plasma is separated from the solid parts of the blood. It is then replaced with plasma from a plasma donor. The donor plasma is pumped into the person. A machine sends the plasma through a tube into the body. If no donated plasma is available, albumin solution can be used. Albumin is an important protein in plasma. Like any medical procedure, plasma exchange poses some risks. It is invasive. This means it involves an object-in this case, a tube-entering the body. Side effects of plasma exchange include infection and blood-clotting issues. You should discuss the benefits and risks of ...
PLASMA-BASED HYDROGEN GENERATION In mid 2011, a plasma-based system is being developed which will generate Hydrogen from sea water using less energy than electrolysis.
MiRNAs have been shown to play important roles in the tumorigenesis and/or development of various cancers. Since it exists stably in the plasma/serum, miRNA appears promising as a new biomarker for the diagnosis and treatment of cancer. In PDAC patients, numerous miRNAs including miR-21, miR-155, miR-196a and miR-210 have been detected in the plasma/serum, and have been suggested to be useful biomarkers for the diagnosis (6,7,9,26). In the present study, we examined the expression of miR-483-3p as well as miR-21 in the plasma of PDAC patient to assess whether these miRNAs would be useful markers for the detection of PDAC and for predicting the clinical status of this tumor. We clearly demonstrated for the first time that the plasma miR-483-3p level was significantly higher in PDAC patients compared to those of HC and IPMN patients and that the AUC value of miR-483-3p for discriminating PDAC from IPMN was higher than that of miR-21. miR-483-3p has been shown to promote cell proliferation through ...
Each unit of whole blood normally is separated into several components. Red blood cells may be stored under refrigeration for a maximum of 42 days, or they may be frozen for up to 10 years. Red cells carry oxygen and are used to treat anemia or blood loss. Platelets are important in the control of bleeding and are generally used in patients with leukemia and other forms of cancer. Platelets are stored at room temperature and may be kept for a maximum of five days. Plasma can be stored frozen for a year before being thawed and transfused. Plasma serves as a source of plasma proteins for patients who are deficient in or have defective plasma proteins and is generally indicated for management of preoperative or bleeding patients who require replacement of multiple plasma coagulation factors. Cryoprecipitated AHF, which contains only a few specific clotting factors, is made from fresh frozen plasma and may be stored frozen for up to one year. Granulocytes are sometimes used to fight infections, ...
A method is described for estimating plasma renin activity by using renin substrate present in plasma. This method differs from other indirect renin assay methods by (1) incubation in the absence of ions thus establishing conditions for zero order kinetics for the reaction between endogeneous renin and substrate and (2) the use of angiotensinase inhibitors di-sodium ethylenediamine tetraacetic acid (EDTA) and d-isopropylfluorophosphate (DFP). Recoveries of renin added to plasma in levels similar to those occurring in plasma are 85% SD±7%.. The incubation was done at pH 5.5 which was shown to be the optimum for human renin reacting with human substrate.. By incubating human plasma samples with known quantities of human renin, evidence was obtained suggesting that factors other than enzyme or total substrate concentrations affect the velocity of angiotensin formation. This variability of reaction rate may be explained by the existence of an inhibitor or activator in this system or by a variation ...
The page below is a sample from the LabCE course Adverse Effects of Fresh Frozen Plasma Transfusion: TRALI, TACO and Allergic Reactions. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online ...
Components of blood have been found to improve health and enhance multiple biological functions in pre-clinical studies of age-related decline. Blood plasma has been particularly important in regulating the complex mechanisms that can cause these effects. The efficacy of plasma is being studied in the clinic for multiple indications. Alkahest has identified a proprietary plasma protein fraction, GRF6019, which shows positive effects on cognitive and motor function in old models. Plasma and plasma protein fractions have been used as human therapies for decades. Some advantages of GRF6019 over plasma may include increased safety, convenience and treatment benefits. Based on the effects observed in laboratory studies, Alkahest is conducting a Phase II study to explore the safety and efficacy of GRF6019 in people with Parkinsons disease (PD).. Impact on Diagnosis/Treatment of Parkinsons Disease ...
Adopted a common technique used in biochemistry, called agarose gel electrophoresis, researchers have investigated the damage to DNA that might have been caused by use of an atmospheric pressure plasma jet. This qualitative and quantitative study could ultimately lead to plasma-based tools for cancer therapy or hospital hygiene and other purposes.
Blood Components & Preparation. UROOJ MUHAMMAD ISMAIL SYED ADNAN ALI WAHIDI NAJMA SOMROO NUZHAT HINA HINA KHAN SANAM QURBAN. Basic Blood Components. Red Blood Cells Platelets Fresh Frozen Plasma (FFP) Cryoprecipitated Anti-hemophilic Factor Granulocytes. Terms to...
We employ emerging molecular technologies to develop new diagnostic approaches. Our focus is on circulating tumour DNA (ctDNA) as a noninvasive modality to assess evolution of solid malignancies. This is DNA originating from cancer cells, carrying tumour-specific genomic alterations, that is present as short cell-free fragments in body fluids such as blood plasma. ctDNA can be collected noninvasively via blood samples and has the potential to be immensely informative.. The field of prenatal diagnostics is revolutionised by non-invasive tests that assay fetal DNA fragments in maternal plasma. Parallel progress in cancer has been lagging, because genomic loci of interest are not well defined, and levels of tumour DNA in plasma are variable and generally lower: 2 ml of plasma may contain as many as 10,000 copies of DNA from healthy cells but only a few dozen copies of the tumour genome. The mechanisms through which tumour DNA reaches blood circulation are unclear, although fragmentation patterns of ...
The proteins found in this ingredient have unique properties that can be used to give wet pet food its recognizable texture. Achieving the correct texture is an important factor in pet food palatability, especially for cats. Albumin, globulins and fibrinogen, which make up most proteins in plasma, produce a stable and compact structure when cooked. Compared to other texture-modifying ingredients, plasma can be used as a nutrient-rich ingredient to improve the overall texture of wet pet food. Not only is it highly palatable, but can provide unique health benefits such as:. ...
During the second quarter of 2015, we received a notice of allowance from the US Patent Office, or USPTO, for our RI-002 patent filed under U.S. patent application 14/592,721 entitled Compositions and Methods for the Treatment of Immunodeficiency, which extends through January 2035. During the third quarter of 2015 our U.S. Patent 9,107,906 was issued by the USPTO. This patent describes methods by which the blending of plasma obtained from normal donors with plasma obtained from donors selected to have high levels of neutralizing antibody titers to RSV form a unique antibody enriched plasma pool and provide for the standardization of the levels of anti-RSV antibodies in the RI-002 final product. Additionally, our patent covers methods of producing hyperimmune globulin compositions to multiple pathogens.. ...
When warfarin reversal must be accomplished rapidly, such as in cases of active bleeding or in preparation for an invasive procedure, multiple options exist, chief among them being fresh frozen plasma (FFP) and four factor prothrombin complex concentrate (4-PCC). Between those two options, the ACCP guidelines suggest (soft recommendation) 4-PCC over FFP. This was based on low level data (very small studies) showing more rapid INR reversal using the former. This study, which came out after publication of the ACCP guidelines, added further weight in favor of 4-PCC in patients deemed appropriate for rapid warfarin reversal in the emergency setting. Though considered low level in that it was a retrospective study, it was larger (around 150 patients in both groups) than prior studies. Despite mounting evidence in favor of 4-PCC some experts (e.g. the authors of this review) remain skeptical as to whether 4-PCC is superior, awaiting information from randomized controlled trials. One such trial has ...
3. 233 Hepatitis C virus (HCV), validation of nucleic acid amplification techniques for the detection streett HCV RNA in plasma pools Guidelines.
accumulation addition additional administration afterwards agent agents aimed albumin allow almost array audience axis bandwidth biological biomedical biomedicine blood cardiac cardiovascular catheter characteristics chase chem coil comparable concentration confirm consecutive consequently contained contrast coupled course density described determine develop diameter dimensional disease dynamic dynamics enable endogenous engineering enhanced entire excitation experimental flash fractional future gating gauss healthy heart hepatic hours identical in vivo included increasing indicates inductively indwelling infarction initial injected injection institute intercept intravenous labeled linear lobes macromolecular mapping mass material materials matrix measured medicine mice might minutes model modulation molecular monitor mouse myocardial myocardium navigator normalizing optical overlay parametric permeability physiology pixel plasma pool post potential preliminary previously prior product ...
While I was visiting Last Chance Corral one of the foals was lethargic and the staff was concerned he may not have received the much needed colostrum. To test the level of antibodies in his blood a snap test is performed. They asked me if I had ever done one….. I dont like blood.. I had not done a snap test but I do like learning. I can draw blood and do many things to keep my horses safe and healthy…I dont like blood. As evidence of how crummy this foal is feeling watch how quietly he stands before, during and after I draw the blood.. Thankfully this little guy had received what he needed. Unfortunately the foal in this photo taken at OSU vet hospital had not. She can be seen here receiving an emergency blood plasma transfusion.. ...
The finding of 24 of 27 negative reactions in patients with KRAS2-negative colorectal cancer is very significant (Table 8),$REFLINK, . These results came from three different studies, and only one laboratory described finding mutated KRAS2 sequences in the plasma from patients with tumors that were demonstrated to not contain mutated KRAS2 genes. In ,60% of these patients with colorectal cancer, one would expect to find polyps as well as other hyperplastic and dysplastic lesions in the adjacent colon (38 , 39) . Many of these pathological lesions have been demonstrated to contain KRAS2 genes with variable mutations at the first two positions of codon 12 (40, 41, 42) . If the DNA from these noncancerous lesions entered the circulation in significant amounts, one would expect to find mutated KRAS2 sequences in the plasma/serum from the majority of these patients, even if their colorectal cancer was negative for mutated genes. However, the data indicate that, in practically all cases, these mutated ...
For a reliable Hammond blood plasma donation center, specializing in paid plasma donation, visit the plasma center at Bio-Blood Components in Hammond, IN.
Blood, Blood Bank, Blood Cell, Blood Transfusion, Cell, Cell Culture, Culture, Fresh Frozen Plasma, Il-10, Immunomodulation, Interleukin, Interleukin-10, Necrosis, Plasma, Platelet, Red Blood Cell, Tnf-alpha
Despite numerous advances in "omics" research, early detection of ovarian cancer still remains a challenge. The aim of this study was to determine whether attenuated total reflection Fourier-transform infrared (ATR-FTIR) or Raman spectroscopy could characterise alterations in the biomolecular signatures of human blood plasma/serum obtained from ovarian cancer patients compared to non-cancer controls. Blood samples isolated from ovarian cancer patients (n = 30) and healthy controls (n = 30) were analysed using ATR-FTIR spectroscopy. For comparison, a smaller cohort of samples (n = 8) were analysed using an InVia Renishaw Raman spectrometer. Resultant spectra were pre-processed prior to being inputted into principal component analysis (PCA) and linear discriminant analysis (LDA). Statistically significant differences (P , 0.001) were observed between spectra of ovarian cancer versus control subjects for both biospectroscopy methods. Using a support vector machine classifier for Raman spectra of ...
Cite as:. A main purpose of sterilization is to kill the harmful microorganisms. In food industry, the representatives of microorganisms which are difficult to sterilize are spore-forming bacteria. Because these bacteria are extremely heat resistant. So it is no exaggeration to say high-pressure / high temperature sterilization method is the only method to sterilize spore-forming bacteria. By the way, plasma sterilization method is used to sterilize the medical equipment. However the present plasma sterilization method cannot be used for food because of containing hydrogen peroxide.. In this study, the authors tried to sterilize Bacillus subtilis which is model bacteria of spore-forming bacteria using plasma-based ion implantation (PBII) method which doesnt use hydrogen peroxide. The result of experimentation, the living spore reduced from 1×108 cfu/ml to 7.8×104 cfu/ml with 20 min exposure. The authors showed that PBII treatment without hydrogen peroxide might be able to sterilize the heat ...
The identification of epidermal growth factor receptor (EGFR)-activating mutations and the subsequent development of EGFR tyrosine kinase inhibitors (TKIs) for advanced EGFR-mutant non-small cell lung cancer (NSCLC) represents a drastic change in treatment paradigms. Several randomised clinical trials have demonstrated that EGFR-TKI administration results in a superior response rate and longer progression-free survival than platinum-based chemotherapy for advanced EGFR-mutant NSCLC.1-3 However, patients who initially respond to EGFR-TKIs eventually acquire resistance.. The mechanisms of acquired EGFR-TKI resistance have been widely studied and several mechanisms have been identified. The most common mechanism of resistance to TKIs, observed in over 50% of patients, is a threonine-to-methionine substitution within the gatekeeper residue at amino acid position 790 (T790M) of the EGFR gene.4-7 EGFR-independent mechanisms include the MET proto-oncogene, receptor tyrosine kinase (MET) amplification ...
Looking for online definition of international sensitivity index in the Medical Dictionary? international sensitivity index explanation free. What is international sensitivity index? Meaning of international sensitivity index medical term. What does international sensitivity index mean?
The performance of the point-of-care Xpert HIV-1 viral load assay was evaluated against the Abbott RealTime PCR m2000rt system. A total of 96 plasma specimens ranging from 2.5 log10 copies ml-1 to 4.99 log10 copies ml-1 and proficiency testing panel specimens were used. Precision and accuracy were checked using the Pearson correlation co-efficient test and Bland-Altman analysis.. RESULTS ...
Study evaluates associations between fresh frozen plasma (FFP) and platelet transfusions with long-term functional outcome and survival in patients with traumatic brain injury (TBI) and moderate hemostatic laboratory abnormalities. Data examined included patient demographics, several initial injury severity metrics, daily laboratory values, Glasgow Outcome Score- Extended (GOSE) scores, Functional Status Examination (FSE) scores, and survival to 6 months. Correlations were evaluated between these variables and transfusion of FFP, platelets, packed red blood cells (RBCs), cryoprecipitate, recombinant factor VIIa, and albumin. Analyses showed significant correlations between poor outcome scores and FFP, platelet, or packed RBC transfusion; the volume of FFP or packed RBCs transfused also correlated with poor outcome. Several measures of initial injury and laboratory abnormalities also correlated with poor outcome. Patient age, initial Glasgow Coma Scale score, and highest recorded serum sodium ...

Non-Thermal Sanitation By Atmospheric Pressure Plasma | SBIR.govNon-Thermal Sanitation By Atmospheric Pressure Plasma | SBIR.gov

Atmospheric pressure plasma is well known to be highly effective in promoting oxidation, enhancing molecular dissociation, and ... ORBITECs Non-Thermal Sanitation by Atmospheric Pressure Plasma technology sanitizes fresh fruits and vegetables without the ... The prototype will also be evaluated for the effect of plasma treatment on food quality. ... designs of the primary operating components of the system will be refined and incorporated into a plasma processing chamber ...
more infohttps://www.sbir.gov/sbirsearch/detail/388226

Plasma cell leukemia revealing a G6PD deficiency | Blood JournalPlasma cell leukemia revealing a G6PD deficiency | Blood Journal

... atypical plasma cells (panel A), leading to the diagnosis of primary plasma cell leukemia. Initial red blood cell transfusion ... Plasma cell leukemia revealing a G6PD deficiency. Anna Raimbault and Nicolas Chapuis ... Plasma cell leukemia revealing a G6PD deficiency. Blood, 128(26), 3178. Accessed January 22, 2018. https://doi.org/10.1182/ ...
more infohttp://www.bloodjournal.org/content/128/26/3178?sso-checked=true

In situ chitosan gelation initiated by atmospheric plasma treatmentIn situ chitosan gelation initiated by atmospheric plasma treatment

CitacióMolina, R. [et al.]. In situ chitosan gelation initiated by atmospheric plasma treatment. "Carbohydrate polymers", 06 ...
more infohttp://upcommons.upc.edu/handle/2117/23099

Therapeutic Plasma ExchangeTherapeutic Plasma Exchange

What Is Therapeutic Plasma Exchange (TPE)?. Therapeutic Plasma Exchange (TPE) is a mode of treatment currently performed for a ... Therapeutic Plasma Exchange (TPE) is a patient treatment during which a large volume of the patients plasma is separated from ... Therapeutic plasma exchange (or TPE), is a patient treatment during which a large volume of the patients plasma is separated ... Therapeutic plasma exchange is considered a non-specific therapy since it removes all plasma constituents, not just those ...
more infohttp://www.plazmafereze.lv/en/procedures/therapeutic-plasma-exchange/30

Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta...Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta...

However, no significant difference was found in plasma vWF levels on admission between the two groups. Plasma vWF level in CAD ... The plasma vWF levels examined at 24 h and 48 h after admission were significantly higher in CAD patients with MACEs than those ... This meta-analysis was performed to evaluate the prognostic value of plasma vWF levels in CAD patients with MACEs. A total of ... is stored in endothelial cells and released into blood plasma upon vascular dysfunction. ...
more infohttps://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-020-01375-7

Plasma - WikipediaPlasma - Wikipedia

... application of plasma in ignition of fuels Plasma smelting, smelting of metals using plasma Quark-gluon plasma, an extremely ... Plasma (album), a 2003 live album by Trey Anastasio Plasma (comics), a fictional character in the Marvel Universe Plasma ... Plasma arc welding, joining of metals by coalescence using plasma arc as a heat source with or without filler metal Plasma ... Plasma or plasm may refer to: Plasma (physics), an ionized state of matter similar to a gas. Common applications include the ...
more infohttps://en.wikipedia.org/wiki/Plasma

Plasma activation - WikipediaPlasma activation - Wikipedia

Plasma activation (or Plasma functionalization) is a method of surface modification employing plasma processing, which improves ... Many types of plasmas can be used for surface activation. However, due to economic reasons, atmospheric pressure plasmas found ... One of them also acts as a gas nozzle producing a stream of plasma. After the plasma stream leaves the arc region, the ions ... flame treatment and various types of plasma activation. Advantage of the plasma activation lies in its ability to achieve all ...
more infohttps://en.wikipedia.org/wiki/Plasma_activation

Inkke - Lil Plasma (Official Audio) - YouTubeInkke - Lil Plasma (Official Audio) - YouTube

Lil Plasma EP Out Now All footage courtesy of Inkke from the Eyes Teeth series. http://inkke.net ... 50+ videos Play all Mix - Inkke - Lil Plasma (Official Audio)YouTube. * The Weeknd - Blinding Lights (Audio) - Duration: 3:24. ... From the "Lil Plasma" EP Out Now. All footage courtesy of Inkke from the Eyes Teeth series.. http://inkke.net ...
more infohttps://www.youtube.com/watch?v=RYh9AH_I_7E&list=PLYOrIW83KSwinIKnPoxRwxwhxsLbpW2O4&index=1

Plasma & LCD TV - Panasonic IndonesiaPlasma & LCD TV - Panasonic Indonesia

Tabel Perbandingan TV Plasma dan TV LCD. TV Plasma TV LCD. Ukuran Layar Layar berukuran 37 inci dan lebih besar, sesuai untuk ... Plasma & LCD TV. Pertanyaan1. Saya dengar bahwa TV plasma dapat burn in setelah beberapa waktu. Apakah sebenarnya yang dimaksud ... TV Plasma adalah yang terbaik dalam memproduksi gambar layar besar yang kuat dengan banyak efek, sementara TV LCD baik dalam ... Apakah bedanya TV Plasma dan TV LCD?. Jawaban8.. Karena keduanya menggunakan metode yang berbeda, maka gambar yang ...
more infohttps://www.panasonic.com/id/support/faq/digital-av/plasma-lcd-tv.html

ESA - Supersonic plasma jets discoveredESA - Supersonic plasma jets discovered

Information from ESAs magnetic field Swarm mission has led to the discovery of supersonic plasma jets high up in our ... Information from ESAs magnetic field Swarm mission has led to the discovery of supersonic plasma jets high up in our ... each satellite has an electric field instrument positioned at the front to measure plasma density, drift and velocity. ... we discovered that these strong electric fields drive supersonic plasma jets. ...
more infohttp://www.esa.int/Applications/Observing_the_Earth/Swarm/Supersonic_plasma_jets_discovered

DigiBio - Plasma coagulation vid oDigiBio - Plasma coagulation vid o

Plasma coag. video Potential Applications. Publications - Media. Press articles Our publications Related publications. Related ...
more infohttp://web.archive.org/web/20081218204543/http:/www.digibio.com/cgi-bin/node.pl?nd=n8

Plasma DynamicsPlasma Dynamics

All items in [email protected] are protected by original copyright, with all rights reserved, unless otherwise indicated. Notify us about copyright concerns ...
more infohttps://dspace.mit.edu/handle/1721.1/52250

Exploring the human plasma proteome.  - PubMed - NCBIExploring the human plasma proteome. - PubMed - NCBI

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
more infohttps://www.ncbi.nlm.nih.gov/pubmed/16104055?dopt=Abstract

Astronomy and Plasma Physics
     | ChalmersAstronomy and Plasma Physics | Chalmers

Extragalactic Astronomy and Plasma Physics and Fusion Energy​ ​. Our research covers a wide range of topics from planetary ... Astronomy and Plasma Physics There are three research units in the division: Galactic Astronomy, Extragalactic Astronomy and ...
more infohttps://www.chalmers.se/en/departments/see/research/Astronomy-and-Plasma-Physics/Pages/default.aspx

Traveling to Mars with Immortal Plasma Rockets | SpaceTraveling to Mars with Immortal Plasma Rockets | Space

... while plasma redeposition depends on the plasma. For my initial study, I adjusted the plasma conditions so there was no plasma ... Plasma rockets are a modern technology that transforms fuel into a hot soup of electrically charged particles, known as plasma ... To do this, we need to understand how a plasma rocket works. The rocket creates a plasma by injecting electrical energy into a ... The most powerful plasma rocket flown in space, called a Hall thruster, would produce only enough thrust to lift a piece of ...
more infohttps://www.space.com/33660-traveling-to-mars-with-immortal-plasma-rockets.html

CSL Plasma Job Listings | Career Search | Monster.comCSL Plasma Job Listings | Career Search | Monster.com

Browse 999 CSL Plasma employment opportunites on our job search engine. Apply now for jobs hiring near you. ... CSL Plasma Careers & Jobs (999 Jobs) Create job alert. Get jobs as soon as theyre posted. Close Sign up for a Monster account ...
more infohttps://www.monster.com/jobs/c-csl-plasma

Plasma Wallpaper - Android app on AppBrainPlasma Wallpaper - Android app on AppBrain

Real-time plasma effect on your screen. 8 different color combinations, 3 unique plasma generation algorithms. ... ... Real-time plasma effect on your screen.. 8 different color combinations, 3 unique plasma generation algorithms.. -----. Visit ... Real-time plasma effect on your screen.. 8 different color combinations, 3 unique plasma generation algorithms.. -----. Visit ... algorithms chiralcode color combinations different effect facebook follow generation give google http like official our plasma ...
more infohttps://www.appbrain.com/app/plasma-wallpaper/com.chiralcode.wallpaper.plasma

HARMONIC PLASMA | Entry | Reaktor User LibraryHARMONIC PLASMA | Entry | Reaktor User Library

HARMONIC PLASMA by Roman Smirnov [email protected] A synth with a character. Explores principles of harmonic tuning.Explore ...
more infohttps://www.native-instruments.com/de/reaktor-community/reaktor-user-library/entry/show/13121/

Induction plasma tube(Patent) | DOE PatentsInduction plasma tube(Patent) | DOE Patents

Induction plasma tube Patent Hull, D.E. An induction plasma tube having a segmented, fluid-cooled internal radiation shield is ... Induction plasma tube Patent Hull, Donald E. (Los Alamos, NM) An induction plasma tube having a segmented, fluid-cooled ... Combination induction plasma tube and current concentrator for introducing a sample into a plasma Patent Hull, Donald E. (Los ... Combination induction plasma tube and current concentrator for introducing a sample into a plasma Patent Hull, D.E.; Bieniewski ...
more infohttps://www.osti.gov/doepatents/biblio/6009963

Fluoxetine increases plasma clozapine concentrations | SpringerLinkFluoxetine increases plasma clozapine concentrations | SpringerLink

Fluoxetine increases plasma clozapine concentrations. Reactions Weekly volume 711, page4(1998)Cite this article ... Fluoxetine increases plasma clozapine concentrations. React. Wkly. 711, 4 (1998). https://doi.org/10.2165/00128415-199807110- ...
more infohttps://link.springer.com/article/10.2165%2F00128415-199807110-00009

Cold Plasma processing - WURCold Plasma processing - WUR

Cold plasma processing is an attractive technology for mild surface decontamination of foods and packaging materials. ... Nitrogen based cold plasma. Many research groups that are active in the field of cold plasma for food applications use helium ... Cold Plasma processing. Cold plasma processing is an attractive technology for mild surface decontamination of foods and ... In addition to this, plasma can also reduce the amount of water used for disinfection of packaging materials. As cold plasma is ...
more infohttps://www.wur.nl/en/Research-Results/Research-Institutes/food-biobased-research/Research-themes/Healthy-and-delicious-foods/Mild-preservation/Cold-Plasma-processing.htm

WIS Plasma Laboratory - SearchWIS Plasma Laboratory - Search

The 3rd SLSP (Spectral Line Shapes in Plasmas) code comparison workshop will be held in Marseille, France, March 2-6, 2015. ... The 5th Spectral Line Shapes in Plasmas code comparison workshop to be held in Vrdnik, Serbia, May 27-31, 2019. ... The 4th Spectral Line Shapes in Plasmas code comparison workshop to be held in Baden, Austria, March 20-24, 2017. ... The 3rd Spectral Line Shapes in Plasmas code comparison workshop to be held in Marseille, France, March 2-6, 2015. ...
more infohttps://plasma-gate.weizmann.ac.il/news/11/111/3rd-SLSP-Workshop/
  • ORBITEC's Non-Thermal Sanitation by Atmospheric Pressure Plasma technology sanitizes fresh fruits and vegetables without the use of consumable chemicals and without significantly raising the temperature of the food, so food taste and quality are not affected. (sbir.gov)
  • Atmospheric pressure plasma is well known to be highly effective in promoting oxidation, enhancing molecular dissociation, and producing free radicals and other types of high energies. (sbir.gov)
  • During this Phase 2 effort, designs of the primary operating components of the system will be refined and incorporated into a plasma processing chamber prototype capable of treating one to two servings of fresh food at a time. (sbir.gov)
  • The prototype will also be evaluated for the effect of plasma treatment on food quality. (sbir.gov)
  • Plasma cells , also called plasma B cells , plasmocytes , plasmacytes , or effector B cells , are white blood cells that secrete large volumes of antibodies . (wikipedia.org)
  • Most of these B cells will become plasmablasts (or "immature plasma cells"), and eventually plasma cells, and begin producing large volumes of antibodies. (wikipedia.org)
  • Plasmablasts secrete more antibodies than B cells, but less than plasma cells. (wikipedia.org)
  • The lifespan, class of antibodies produced, and the location that the plasma cell moves to also depends on signals, such as cytokines , received from the T cell during differentiation. (wikipedia.org)
  • For example, plasma cells will likely secrete IgG3 antibodies if they matured in the presence of the cytokine interferon-gamma . (wikipedia.org)
  • Since B cell maturation also involves somatic hypermutation (a process completed before differentiation into a plasma cell), these antibodies frequently have a very high affinity for their antigen. (wikipedia.org)
  • For example, administration of polio vaccine , which is made from killed or attenuated (weakened) poliovirus, is followed by the appearance in the plasma of antibodies that react with poliovirus and effectively prevent the onset of disease. (britannica.com)
  • The proteins and antibodies in plasma are also used in therapies for rare chronic conditions. (nationwidechildrens.org)
  • Plasma (from Ancient Greek πλάσμα ​ , meaning 'moldable substance' ) is one of the four fundamental states of matter , and was first described by chemist Irving Langmuir in the 1920s. (wikipedia.org)
  • The term "plasma" was coined by Irving Langmuir in 1928. (wikipedia.org)
  • Lewi Tonks and Harold Mott-Smith, both of whom worked with Irving Langmuir in the 1920s, recall that Langmuir first used the word "plasma" in analogy with blood. (wikipedia.org)
  • Mott-Smith recalls, in particular, that the transport of electrons from thermionic filaments reminded Langmuir of "the way blood plasma carries red and white corpuscles and germs. (wikipedia.org)
  • In order to aid in the design of high-power Hall thrusters and provide experimental validation for existing modeling efforts, plasma potential and Langmuir probe measurements were performed in the near-field plume of the NASA 300M Hall thruster. (archive.org)
  • However, Ostrikov says that his team's plasma flashlight probably relied more on reactive species of gas than on UV to kill bacteria because there wasn't much UV light present in this plasma. (popularmechanics.com)
  • Pulsed atmospheric arc technology improves the arc stability at low electric currents, maximizes the discharge volume, and together with it the production of reactive species for plasma activation, while at the same time reducing the size of the driving high voltage electronics. (wikipedia.org)
  • I have no personal experience but saw a study saying that it actually increases your ferratin counts to donate plasma Because they return red blood cells, the risk of iron depletion is low. (obesityhelp.com)
  • Plasma donation doesn't cause iron depletion. (obesityhelp.com)
  • A strain similar to this one endangered not merely the Rachelis system, but the U.S.S. Enterprise NCC-1701-D and her crew during their mission to transport specimens of plasma plague to Science Station Tango Sierra as part of the effort to combat the outbreak in the Rachelis system. (startrek.com)
  • Artist's rendition of the Earth's plasma fountain , showing oxygen, helium, and hydrogen ions that gush into space from regions near the Earth's poles. (wikipedia.org)
  • Importantly, the plasma activation can be performed at the atmospheric pressure using air or typical industrial gases including hydrogen, nitrogen and oxygen. (wikipedia.org)
  • After the plasma stream leaves the arc region, the ions recombine quickly, leaving the hot gas having high concentrations of chemically active hydrogen, nitrogen and oxygen atoms and compounds, which is also called remote plasma. (wikipedia.org)
  • Plasma and ionized gases have properties and display behaviours unlike those of the other states, and the transition between them is mostly a matter of nomenclature and subject to interpretation. (wikipedia.org)
  • Various gases can be used to create the plasma in. (everything2.com)
  • as plasma physicists call them, with various colours using a mixture of gases. (everything2.com)
  • The latest weapon in the war on germs: a battery-powered handheld plasma flashlight that could cut through biofilm, potentially allowing doctors in the field to cut through infections. (popularmechanics.com)
  • The interior of the Sun is an example of fully ionized plasma, along with the solar corona and stars . (wikipedia.org)
  • They might also use lasers and other methods to get the plasma up to 150 to 300 million degrees Celsius (10 to 20 times hotter than the Sun's core). (universetoday.com)
  • We use high-resolution spectral emission line data obtained by the SERTS instrument during three rocket flights to demonstrate a new approach for constraining electron densities of solar active region plasma.We apply differential emission measure (DEM) forward-fitting techniques to characterize the multithermal solar plasma producing the observed EUV spectra, with constraints on the high-temperature plasma from the Yohkoh Soft X-ray Telescope. (archive.org)
  • The plasma flashlight that the scientists created produces a faint light, but enough plasma to be effective against bacteria. (popularmechanics.com)
  • The Plasma Knife resembles tools used for radiosurgery, but has the advantage that it produces plasma ( hot ionised gas - not the liquid sort of plasma found in blood) which penetrates the outer porous layer of dead tissue without damaging it. (wired.com)
  • Then an enormous amount of electricity is run through the chamber, heating up the hydrogen into a plasma state. (universetoday.com)
  • Plasma is an electrically neutral medium of unbound positive and negative particles (i.e. the overall charge of a plasma is roughly zero). (wikipedia.org)
  • plasma cells Antibody-producing cells found in the epithelium of the lungs and gut and also in bone-forming tissue. (encyclopedia.com)
  • However, due to economic reasons, atmospheric pressure plasmas found most applications. (wikipedia.org)
  • Lipids are present in plasma in suspension and in solution. (britannica.com)
  • At noncommercial donation sites, people can donate plasma every 28 days, up to 13 times a year. (nationwidechildrens.org)
  • Plasma processing achieves this effect through a combination of reduction of metal oxides, ultra-fine surface cleaning from organic contaminants, modification of the surface topography and deposition of functional chemical groups. (wikipedia.org)
  • One bottle contained enough distilled water to reconstitute the dried plasma contained within the other bottle. (wikipedia.org)
  • Because atoms have discrete energy levels, the photons emitted also have discrete energies, causing the light emitted by the plasma ball to have discrete colours. (everything2.com)
  • But rather than being a weapon, the Plasma Knife is a surgical instrument that could save lives. (wired.com)
  • Differentiation of mature B cells into plasma cells is dependent upon the transcription factors Blimp-1 / PRDM1 and IRF4 . (wikipedia.org)
  • There are three main byproducts that are a result of the plasma gasification process: synthetic gas (syngas), slag and heat. (howstuffworks.com)
  • Separate download of PLASMA source is not required. (utk.edu)
  • A normal medical Plasma Knife relies on mains power, but the commando version is described as being low-power and wearable, suggesting it has a separate power pack. (wired.com)
  • Just why the plasma flashlight is so successful, however, remains an open question: Scientists are not exactly sure which component deals the death blow to microbes, according to Ken Ostrikov, a co-author of the new study and a plasma researcher with Australia's national science agency, CSIRO (Commonwealth Scientific and Industrial Research Organization). (popularmechanics.com)
  • In 2295, Doctor Susan Nuress conducted significant research into plasma plague in response to a similar outbreak on planet Obi VI at that time. (startrek.com)
  • The Warwick Plasma Calculator (WPC) is an ongoing project to develop and maintain interactive web-based tools that appeal both to students for educational purposes as well as to scientists who wish to make a quick calculation in support of their research. (warwick.ac.uk)
  • Phoronix articles, reviews and news stories covering Plasma 5.9 . (phoronix.com)
  • The manual download of PLASMA source is not needed using the installer. (utk.edu)
  • In the event the installer does not fit your needs, a makefile is provided in the PLASMA source. (utk.edu)
  • The price of insulation would decrease, efficiencies in energy-saving techniques would increase and plasma gasification plants would have another substantial source of income apart from selling electricity back to the grid. (howstuffworks.com)
  • Everyone is welcome to use these tools but we do ask that when you use our material in publications or presentations you acknowledge us by mentioning the Warwick Plasma Calculator and our website. (warwick.ac.uk)
  • Plasma is a state of matter in which an ionized gaseous substance becomes highly electrically conductive to the point that long-range electric and magnetic fields dominate the behaviour of the matter. (wikipedia.org)
  • A cell may stay in this state for several days, and then either die or irrevocably differentiate into a mature, fully differentiated plasma cell. (wikipedia.org)
  • Plasma is essentially ionized gas, a free-flowing state of matter that is electrically charged, David Graves says. (popularmechanics.com)
  • Nevertheless, the decision was made to develop a dried plasma package for the armed forces as it would reduce breakage and make the transportation, packaging, and storage much simpler. (wikipedia.org)
  • The resulting dried plasma package came in two tin cans containing 400 cc bottles. (wikipedia.org)
  • Graves says it's so difficult to prove the case for charged gas over the other suspects "because when you use the plasma, you get the whole package. (popularmechanics.com)
  • We strongly recommend to use the latest version of the plasma installer , which will automatically download this package and install all other dependencies if required. (utk.edu)
  • Plasma cell with distinct clear perinuclear region of the cytoplasm containing a large number of Golgi bodies . (wikipedia.org)
  • The gas in the plasma ball is at subatmospheric pressure, usually around one kPa. (everything2.com)
  • It''s light and wispy, and according to Dr. Circeo, it has the potential to revolutionize the plasma waste treatment industry. (howstuffworks.com)
  • Observations of DC electric fields and associated E x B plasma drifts gathered by the Vector Electric Field Investigation (VEFI) on the Air Force Communication/Navigation Outage Forecasting System (C/NOFS) satellite are presented. (archive.org)
  • The heat created by plasma facilities is considerable, measured in thousands of degrees Centigrade. (howstuffworks.com)
  • Plasma may be the most abundant form of ordinary matter in the universe , although this hypothesis is currently tentative based on the existence and unknown properties of dark matter . (wikipedia.org)
  • If you want to donate plasma to help others in need, you will go through a screening process. (nationwidechildrens.org)
  • the green area is the aurora borealis , where plasma energy pours back into the atmosphere. (wikipedia.org)
  • If you put in a gas with a smaller energy distance between atomic levels and one with larger distance between energy levels, you can get the plasma to excite the former near the wall and the latter near the center, giving you a nice multicoloured streamer. (everything2.com)
  • The major solute of plasma is a heterogeneous group of proteins constituting about 7 percent of the plasma by weight. (britannica.com)
  • Four major TV manufacturers - Fujitsu, Pioneer, Samsung and Philips - have said they have no immediate plans to incorporate laser TV into their product lines, having already made significant investments in plasma and LCD. (smh.com.au)
  • We] will continue to be committed to developing plasma screen technology,' said Milton Kaloudis, marketing manager, Fujitsu General. (smh.com.au)
  • Using a quick blast of plasma to break up biofilms would make it easier for doctors and dentists to deal with infection. (popularmechanics.com)
  • They make up just 2 in 50 people, their plasma is universal. (nationwidechildrens.org)
  • Fresh frozen plasma is on the WHO Model List of Essential Medicines , the most important medications needed in a basic health system . (wikipedia.org)