Plant Tumors
Agrobacterium tumefaciens
Rhizobium
Plants, Genetically Modified
Plant Leaves
Plant Proteins
Plant Roots
Plant Extracts
Plants, Medicinal
Plant Development
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Cell Wall
Streptothricins
Serpins
A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.
Agrobacterium
Neuroendocrine Tumors
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
Carcinoid Tumor
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
Neurosecretory Systems
Crassulaceae
Teratoma
A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)
Research
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Biomedical Research
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Nanoparticles
Entosis
Organizers, Embryonic
Cells in certain regions of an embryo that self-regulate embryonic development. These organizers have been found in dorsal and ventral poles of GASTRULA embryos, including Spemann organizer in amphibians, and Hensen node in chicken and mouse. These organizer cells communicate with each other via a network of secreted signaling proteins, such as BONE MORPHOGENETIC PROTEINS and their antagonists (chordin and noggin).
Ipomoea nil
Ipomoea
Saussurea
Taraxacum
Plantago
Photoperiod
Neoplasm Metastasis
Neoplasms
Gene Expression Regulation, Neoplastic
Molecular markers and cell cycle inhibitors show the importance of cell cycle progression in nematode-induced galls and syncytia. (1/273)
Root knot and cyst nematodes induce large multinucleated cells, designated giant cells and syncytia, respectively, in plant roots. We have used molecular markers to study cell cycle progression in these specialized feeding cells. In situ hybridization with two cyclin-dependent kinases and two cyclins showed that these genes were induced very early in galls and syncytia and that the feeding cells progressed through the G2 phase. By using cell cycle blockers, DNA synthesis and progression through the G2 phase, or mitosis, were shown to be essential for gall and syncytium establishment. When mitosis was blocked, further gall development was arrested. This result demonstrates that cycles of endoreduplication or other methods of DNA amplification are insufficient to drive giant cell expansion. On the other hand, syncytium development was much less affected by a mitotic block; however, syncytium expansion was inhibited. (+info)Ti plasmids from Agrobacterium characterize rootstock clones that initiated a spread of crown gall disease in Mediterranean countries. (2/273)
Crown gall caused by Agrobacterium is one of the predominant diseases encountered in rose cultures. However, our current knowledge of the bacterial strains that invade rose plants and the way in which they spread is limited. Here, we describe the integrated physiological and molecular analyses of 30 Agrobacterium isolates obtained from crown gall tumors and of several reference strains. Characterization was based on the determination of the biovar, analysis of 16S ribosomal DNA restriction fragment length polymorphisms by PCR (PCR-RFLP), elucidation of the opine type, and PCR-RFLP analysis of genes involved in virulence and oncogenesis. This study led to the classification of rose isolates into seven groups with common chromosome characteristics and seven groups with common Ti plasmid characteristics. Altogether, the rose isolates formed 14 independent groups, with no specific association of plasmid- and chromosome-encoded traits. The predominant Ti plasmid characteristic was that 16 of the isolates induced the production of the uncommon opine succinamopine, while the other 14 were nopaline-producing isolates. With the exception of one, all succinamopine Ti plasmids belonged to the same plasmid group. Conversely, the nopaline Ti plasmids belonged to five groups, one of these containing seven isolates. We showed that outbreaks of disease provoked by the succinamopine-producing isolates in different countries and nurseries concurred with a common origin of specific rootstock clones. Similarly, groups of nopaline-producing isolates were associated with particular rootstock clones. These results strongly suggest that the causal agent of crown gall disease in rose plants is transmitted via rootstock material. (+info)Cell-division factors from Vinca rosca L. crown gall tumor tissue. (3/273)
A cell-division factor has been precipitated from extracts of cultured Vinca rosea L. crown gall tumor tissue by using the mercuric acetate procedure previously employed by Wood and colleagues to obtain their "cytokinesin I." On the basis of its mass spectrum, ultraviolet light absorbancy spectra, solubilities, chromatographic migration values, and growth activity, the factor is ribosyl-trans-zeatin, that is, 6-(4-hydroxy-3-methyl-trans-2-butenylamino)-9-beta-D-ribofuranosylpurine. Ribosylzeatin has now been isolated from tumor tissue by four experimental techniques; any possibility that it is an artifact seems to have been eliminated. Contrary to the report by Wood and colleagues, synthetic ribosylzeatin is precipitated from an aqueous solution by mercuric acetate, provided the complete precipitation procedure is utilized. These facts and others discussed strongly support our suggestion that ribosylzeatin was present in the preparation ("cytokinesin I") examined by Wood and colleagues in several biological assays. The reasons advanced by Wood and others for rejecting this suggestion have been found either not to be pertinent to the question or to have insufficient experimental bases. (+info)An inherited "neoplasm" in fungus. (4/273)
An abnormal growth form in the fungus Schizophyllum commune is described that interferes with the development of reproductive structures. The abnormality, which takes the form of relatively large, compact, hemispherical bodies, depends on a dominant Mendelian gene, mound, for its expression. When mound is expressed in a mycelium that has the potential to form fruiting bodies, the fruiting response is affected and the effect is variable within a replicate series: fruiting bodies may be normal or abnormal, abort at various stages, or not develop at all. Occasionally, fruit bodies are overgrown and are completely enveloped by the hemispherical bodies. When hyphae from hemispherical bodies are subcultured, a seemingly normal mycelium forms that eventually differentiates hemispherical structures, but the ability to form fruiting bodies in not expressed. Continuous mycelial subculture has shown this loss of fruiting expression to be a permanent transformation, which is demonstrated to be a characteristic of hemispherical bodies. (+info)Suppression of the neoplastic state with the acquisition of specialized functions in cells, tissues, and organs of crown gall teratomas of tobacco. (5/273)
The neoplastic state in cells of tissues and organs that develop from cloned lines of crown gall teratomas of tobacco may be completely but reversibly suppressed. Stems and leaves found on teratoma shoots may appear morphologically normal and such organs contain all of the specialized cell types and are histologically and functionally indistinguishable from those found in normal tobacco shoots of comparable age. When however, specialized cells of several different kinds that are present in stems and leaves of the teratomas are excised from the plant and grown on a basic culture medium they again assume their neoplastic properties. The results of this study indicate that the morphogenetic factors and mechanisms that govern so precisely growth, cellular differentiation, and organogenesis during the normal course of development can completely suppress the tumorous state, leading to the formation of cells, tissues, and organs that appear normal in every respect but are, in fact, inherently neoplastic. Whether the normal or tumor phenotype is expressed appears to depend on the activation or repression of select biosynthetic systems, one of which, the auxin sytems, has been identified here. (+info)High relatedness and inbreeding at the origin of eusociality in gall-inducing thrips. (6/273)
Within the haplodiploid eusocial gall-inducing thrips, a species-level phylogeny combined with genetic data for five eusocial species enables an inference of levels of relatedness and inbreeding values for lineages at the origin of eusociality. Character optimization using data from five eusocial species indicates that the lineage or lineages where eusociality is inferred to have originated exhibit relatedness of 0.64-0.92, and F(IS) of 0.33-0.64. The high inbreeding coefficients found in these eusocial thrips have increased relatedness among and within both sexes and have reduced the haplodiploidy-induced relatedness asymmetries [Hamilton, W. D. (1964) J. Theor. Biol. 7, 1-52]. These results indicate that unusually high relatedness is associated with the origin of eusociality, and they suggest a role for inbreeding in the evolution of bisexual helping. (+info)Bruchins: insect-derived plant regulators that stimulate neoplasm formation. (7/273)
Pea weevil (Bruchus pisorum L.) oviposition on pods of specific genetic lines of pea (Pisum sativum L.) stimulates cell division at the sites of egg attachment. As a result, tumor-like growths of undifferentiated cells (neoplasms) develop beneath the egg. These neoplasms impede larval entry into the pod. This unique form of induced resistance is conditioned by the Np allele and mediated by a recently discovered class of natural products that we have identified from both cowpea weevil (Callosobruchus maculatus F.) and pea weevil. These compounds, which we refer to as "bruchins," are long-chain alpha,omega-diols, esterified at one or both oxygens with 3-hydroxypropanoic acid. Bruchins are potent plant regulators, with application of as little as 1 fmol (0.5 pg) causing neoplastic growth on pods of all of the pea lines tested. The bruchins are, to our knowledge, the first natural products discovered with the ability to induce neoplasm formation when applied to intact plants. (+info)Leifsonia poae gen. nov., sp. nov., isolated from nematode galls on Poa annua, and reclassification of 'Corynebacterium aquaticum' Leifson 1962 as Leifsonia aquatica (ex Leifson 1962) gen. nov., nom. rev., comb. nov. and Clavibacter xyli Davis et al. 1984 with two subspecies as Leifsonia xyli (Davis et al. 1984) gen. nov., comb. nov. (8/273)
The new genus Leifsonia gen. nov. with two new species, Leifsonia poae sp. nov. (type strain VKM Ac-1401T) and Leifsonia aquatica (ex Leifson 1962) nom. rev., comb. nov. (the type species, with VKM Ac-1400T = DSM 20146T = JCM 1368T as type strain), is proposed to accommodate bacteria found in Poa annua root gall, induced by the nematode Subanguina radicicola, and 'Corynebacterium aquaticum' Leifson 1962. Further, it is proposed to reclassify Clavibacter xyli Davis et al. 1984 with two subspecies in the new genus as Leifsonia xyli (Davis et al. 1984) comb. nov., Leifsonia xyli subsp. xyli (Davis et al. 1984) comb. nov. and Leifsonia xyli subsp. cynodontis (Davis et al. 1984) comb. nov. Members of the proposed genus are characterized by coryneform morphology, peptidoglycans based upon 2,4-diaminobutyric acid, the major menaquinone MK-11, phosphatidylglycerol and diphosphatidylglycerol as principal phospholipids, the high content of anteiso- and iso-branched saturated fatty acids, and a DNA G+C base composition of 66-73 mol%. They form a distinct phylogenetic branch attached to the line of descent of Agromyces spp. The new and reclassified species of the new genus clearly differ from each other phylogenetically and phenetically and can be recognized by their morphologies, the cell wall sugar composition, the requirement of complex media for growth, and numerous physiological characteristics, including the oxidase reaction. (+info)
The presence and characterization of a virF gene on Agrobacterium vitis Ti plasmids. - Nuffield Department of Obstetrics and...
Reprogramming of human cancer cells to pluripotency for models of cancer progression | The EMBO Journal
Crown Gall Disease Detection Pt 1 - AgInfo.net
Comparison of T-DNA oncogene complements of Agrobacterium tume...
KAKEN - Research Projects | Search for genes involved in plant tumor and teratoma formation (KAKENHI-PROJECT-05640701)
Subject: Vitis riparia / Journal: Plant disease / Publication Year: 2016 / Subject: vineyards - PubAg Search Results
Insect-Induced Plant Galls of CaliforniaEcology Center
The presence of an ER exit signal determines the protein sorting upon ER exit in yeast | Biochemical Journal
Automated Identification of Tumor Microscopic Morphology based on Macr by Pilar Beatriz Garcia-Allende, Venkataramanan...
Diversity of gene expression in adenocarcinoma of the lung | PNAS
Knopper Galls (NOTCOT)
Search Results
Numac Bit Mocc Navy - H&S Craftsmanship
Insight into the Bacterial Endophytic Communities of Peach Cultivars Related to Crown Gall Disease Resistance - DOE Joint...
Regulation of hyu gene expression in Agrobacterium tumefaciens strains RU-AE01 and RU-OR - OpenThesis
A simple and efficient PCR method for the detection of Agrobacterium tumefaciens in plant tumours - Cubero - 2001 - Journal of...
Agrobacterium tumefaciens</i> responses to plant-derived signaling molecules. - Agriculture and Agri-Food Canada...
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
BacMap
BacMap
Diamond Publications - Search Results
Crown Gall on a Willow Tree | Home Guides | SF Gate
Biology, Ecology, and Evolution of Gall-Inducing Arthropods
Re: what does cancer look like in plants, specifically in sunflower plants?
Frontiers | Reprogramming of the Developmental Program of Rhus javanica During Initial Stage of Gall Induction by...
Subject: nopaline - PubAg Search Results
How to make a tumour: cell type specific dissection of Ustilago maydis-induced tumour development in maize leaves
The Ti Plasmid of Agrobacterium Tumefaciens - a Plant-Oriented Gene Vector :: MPG.PuRe
Expression of the Arabidopsis Transposable Element Tag1 Is Targeted to Developing Gametophytes | Genetics
Gall - Simple English Wikipedia, the free encyclopedia
Nopaline - Wikipedia
Product Detail - Crown Gall: Advances in Understanding Interkingdom Gene...
Predictions of tumour morphological stability and evaluation against experimental observations | Journal of The Royal Society...
Molecular Microbiology - Volume 2, Issue 3 - May 1988 - Wiley Online Library
Donald P. Shiley BioScience Center: BioSketch
Gall - Wikipedia
Octopine tablet: buy octopine tablet 10 tablets pack online at best price in india | 1mg
PTIA (Plataforma de Testes de Intrusão Avançada) (TECNOLOGIA (APP (Digital…
View source for YesU - SubtiWiki
PATC Systems Workshop: Programming MareNostrum 4 | BSC-CNS
ASMscience | The Agrobacterium Ti Pla
Transformation of Arabidopsis thaliana with Agrobacterium tumefaciens - NASA/ADS
DOAB: Directory of Open Access Books
Agrobacterium Protocols by Kevan M. A. Gartland, Michael R. Davey - Access IT Systems Books
Molecular Plant Pathology - Pathogen Profiles - BSPP
Escribed [59]. Briefly, the AtEHD constructs were cloned in pBINplus [60] and introduced | FGFR/VEGFR inhibitor-vegfrinhibitor...
Publications
BIOLOGICAL CONTROL OF GROWN GALL IN HORTICULTURE
Habits and Traits of Gall Wasps
Métodos para la detección de Agrobacterium a partir de muestras de material vegetal, suelo y agua
Why Do People Fear G.M.O.s? - Freakonomics Freakonomics
Expression of Anti-microbial Genes in Transgenic Grapevines for Enhanced Disease Resistance <span class=post-format-icon minor...
Unbenanntes Dokument
DEVELOPING A GENOME-SCALE ASSAY TO PROBE THE EXPRESSION RESPONSE OF PHYLLOXERA (DAKTULOSPHAIRA VITIFOLIAE FITCH)-INDUCED ROOT...
post by K J Gunderson
WISTERIA DISEASES | Old House Web
Positions available - Semantic Scholar
Cherry gall wasp | Montgomeryshire Wildlife Trust
Cherry gall wasp | The Wildlife Trusts
RCSB PDB - 2FSQ: Crystal Structure of the Conserved Protein of Unknown Function ATU0111 from Agrobacterium tumefaciens str. C58
NCAIM | National Collection of Agricultural and Industrial Microorganisms
Mycotaxon: Volume 80 Article Abstract
TIGR01726
Sprite rotation - Graphics - Community | MonoGame
Liver & Gall
HSVG misson
Tim Gall | CaringBridge
Plant Tumors | Harvard Catalyst Profiles | Harvard Catalyst
"Plant Tumors" by people in Harvard Catalyst Profiles by year, and whether "Plant Tumors" was a major or minor topic of these ... Plant tumors or galls usually form in response to the action of a pathogen or a pest. (Holliday, P., A Dictionary of Plant ... "Plant Tumors" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Plant Tumors" by people in Profiles. ...
Toxins | Free Full-Text | Ribosome-Inactivating Proteins: From Plant Defense to Tumor Attack
Ricin, the plant RIP prototype that comprises a catalytic A subunit linked to a galactose-binding lectin B subunit to allow ... The most promising way to exploit plant RIPs as weapons against cancer cells is either by designing molecules in which the ... Here, we will provide a comprehensive picture of plant RIPs and discuss successful designs and features of chimeric molecules ... toxic domains are linked to selective tumor targeting domains or directly delivered as suicide genes for cancer gene therapy. ...
Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice. - PubMed - NCBI
Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice.. Shukla S1, Wen AM, Ayat NR, ... Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice ... Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice ... Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice ...
Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants. - PubMed - NCBI
Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants.. Brioudes F1, Thierry ... Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants ... Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants ... Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants ...
Plant extract may help fight brain tumour-23501
Cushing Disease is caused by a tumour in the pituitary gland in the brain. The tumour secrets increased amounts of the stress ... Treatment with a plant extract alleviates symptoms of Cushing Disease caused by a tumour in the brain, scientists say. ... Plant extract may help fight brain tumour 13th February, 2015 09:54:55 ... BERLIN: Treatment with a plant extract alleviates symptoms of Cushing Disease caused by a tumour in the brain, scientists say. ...
Activation of the cAMP Pathway in Ustilago maydis Reduces Fungal Proliferation and Teliospore Formation in Plant Tumors
Molecular Plant-Microbe Interactions 13:1034-1040...Julia Krüger , 1 Gabriel Loubradou , 1 Gerhard Wanner , 2 Erika Regenfelder ... In the resulting tumors, the amount of fungal material is drastically reduced and fungal development is arrested at the stage ... tight regulation of the cAMP pathway is crucial for fungal development within the plant but does not interfere with the tumor ... as null mutants in any component of the pathway fail to form tumors. Here we show that moderate activation of the pathway ...
Cell Walls of Crown-Gall Tumors and Embryonic Plant Tissues Lack Agrobacterium Adherence Sites | Science
Crown-gall tumor initiation by Agrobacterium tumefaciens is inhibited by cell walls from normal dicotyledonous plants but not ... Cell Walls of Crown-Gall Tumors and Embryonic Plant Tissues Lack Agrobacterium Adherence Sites ... Cell Walls of Crown-Gall Tumors and Embryonic Plant Tissues Lack Agrobacterium Adherence Sites ... Cell Walls of Crown-Gall Tumors and Embryonic Plant Tissues Lack Agrobacterium Adherence Sites ...
Effect of Inhibitors of Plant Cell Division on Mammalian Tumor Cells in Vitro | Cancer Research
Effect of Inhibitors of Plant Cell Division on Mammalian Tumor Cells in Vitro. Shmuel Zilkah, Michael E. Osband and Ronald ... We studied the activity of 14 compounds, all of which have been shown to interfere in plant cell division, in two animal tumor ... These results indicate that some inhibitors of plant cell division are capable of inhibiting the proliferation of animal tumor ... Effect of Inhibitors of Plant Cell Division on Mammalian Tumor Cells in Vitro ...
Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells
... *Authors: * ... The present in vitro study demonstrates the antitumor effects of novel plant derived agents in human neuroendocrine tumor cells ... The plant was originally bought at a market in Vietnam. Aerial parts of the plant were successively extracted in ... Neuroendocrine tumors (NETs) represent rare tumors that are derived from cells of the embryonic neural crest. They account for ...
A Tumor Suppressor Homolog, AtPTEN1, Is Essential for Pollen Development in Arabidopsis | Plant Cell
Hardie, D.G. (1999). Plant protein serine/threonine kinases: Classification and functions. Annu. Rev. Plant Physiol. Plant Mol ... L), (P), and (Q) Tinopal/DAPI double-stained mature pollen from a control plant (L) and RNAi plants ([P] and [Q]). Enlarged ... Our study characterized a PTEN homolog in a higher plant and identified its function in pollen development. The PTEN tumor ... Your Name) has sent you a message from Plant Cell Message Body (Your Name) thought you would like to see the Plant Cell web ...
Research on the Immunomodulation and Anti-tumor Activity of Plant Polysaccharides--《Journal of Beihua University(Natural...
It has been recognized all over the world and plant polysaccharides have anti-tumor effect through their immunomodulating ... The immunomodulating effect and anti-tumor activity of many kinds of plant polysaccharides are introduced in this article. ... The normal immunity system can identify and kill tumor cells, however, the occurrence rate of tumor will enhance if it lacks of ... Research on the Immunomodulation and Anti-tumor Activity of Plant Polysaccharides. GONG Dan~1,DU Pei-ge~2,CUI Xin-ying~2 (1.222 ...
KAKEN - Research Projects | Search for genes involved in plant tumor and teratoma formation (KAKENHI-PROJECT-05640701)
Agrobacterium / Plant tumor / Teratoma / Differential hybridization / Differential display / Regeneration / Wound Stress / ... Search for genes involved in plant tumor and teratoma formation. Research Project ... Unfortunately, resulting transgenic plants did not show any phenotypic abnormality. However, the gene expression was induced by ... We assumed that in these tissues, the genes involved in plant differentiation could be induced or repressed, and thus current ...
tks | publisher, event organiser, media agency | Drug candidate shrinks tumor when delivered by plant virus nanoparticle - tks ...
Drug candidate shrinks tumor when delivered by plant virus nanoparticle. Chimica Oggi-Chemistry Today ... Inside tumors, the nanoparticles gather inside the lysosomal compartments of cancer cells, where they are, in essence, digested ... The researchers say delivery of the phenanthriplatin into the tumor led to its improved performance over cisplatin or free ... The long, thin tobacco mosaic virus nanoparticles are naturals for delivering the drug candidate into tumors, said Steinmetz, ...
Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study |...
Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study. T. Kohl ... Plant-derived human papillomavirus 16 E7 oncoprotein induces immune response and specific tumor protection. Cancer Res. 62:3654 ... Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study ... Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study ...
A new extract of the plant calendula officinalis produces a dual in vitroeffect: cytotoxic anti-tumor activity and lymphocyte...
In this study, we evaluated the in vitro cytotoxic anti-tumor and immunomodulatory activities and in vivo anti-tumor effect of ... In vivo anti-tumor activity was evaluated in nude mice bearing subcutaneously human Ando-2 melanoma cells. The LACE extract ... Tumor cell lines derived from leukemias, melanomas, fibrosarcomas and cancers of breast, prostate, cervix, lung, pancreas and ... The intraperitoneal injection or oral administration of LACE extract in nude mice inhibits in vivo tumor growth of Ando-2 ...
Recombinant plant-expressed tumour-associated MUC1 peptide is...
Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice.: ... Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice.. ... In this study, we used the MUC1 TR peptide as a test antigen to determine whether a plant-expressed human tumour-associated ... The results indicate that a plant-derived human tumour-associated antigen is equivalent to the human antigen in the context of ...
Dark-Induced Accumulation of mRNA for a Homolog of Translationally Controlled Tumor Protein (TCTP) in Pharbitis : Plant and...
Published on behalf of Japanese Society of Plant Physiologists Volume 39, issue 3, pages 357-360. Published in print March 1998 ... Keywords: Dark induction; Flowering; Pharbitis; Photoperiod; Phytochrome; Translationally controlled tumor protein Journal ... A cDNA encoding a homolog of human translationally controlled tumor protein (TCTP) was isolated from cotyledons of the short- ... A cDNA encoding a homolog of human translationally controlled tumor protein (TCTP) was isolated from cotyledons of the short- ...
Genetically modified plant may boost supply of a powerful malaria drug | Science News
... researchers tripled the amount of an antimalarial compound naturally produced by sweet wormwood plants. ... Derailing them could help fight tumors By Esther Landhuis. July 10, 2020. ... News in Brief Plants Genetically modified plant may boost supply of a powerful malaria drug. Researchers tripled the amount of ... More Stories from Science News on Plants * Tech Bubble-blowing drones may one day aid artificial pollination By Maria Temming. ...
Regeneration of Normal and Fertile Plants That Express Octopine Synthase, from Tobacco Crown Galls after Deletion of Tumor...
... from Tobacco Crown Galls after Deletion of Tumor-Controlling Functions ... Regeneration of Normal and Fertile Plants That Express Octopine Synthase, ... Regeneration of Normal and Fertile Plants That Express Octopine Synthase, from Tobacco Crown Galls after Deletion of Tumor- ... 1982). Regeneration of Normal and Fertile Plants That Express Octopine Synthase, from Tobacco Crown Galls after Deletion of ...
Phosphoproteomic analysis of interacting tumor and endothelial cells identifies regulatory mechanisms of transendothelial...
Plant Pathology. Plant nutrient acquisition entices herbivore. *. Working Life. The universe in a classroom ... The exit of metastasizing tumor cells from the vasculature, extravasation, is regulated by their dynamic interactions with the ... From the 2669 unique phosphorylation sites identified, 77 and 43 were differentially phosphorylated in the tumor cells and ... Overall, cell-specific phosphoproteomic analysis provides a bidirectional map of contact-initiated signaling between tumor and ...
Notching Up Tumor Progression | Science Signaling
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils | Science
Plant Pathology. Plant nutrient acquisition entices herbivore. *. Working Life. The universe in a classroom ... This study identifies systemic cross-talk between lung tumors and bones: Lung tumors can remotely activate Ocn+ osteoblastic ... Ocn+ cells affect distant tumor progression because experimentally reducing the number of these cells limits lung tumor growth ... and their ability to modulate tumor progression. Most tumor-infiltrating myeloid cells derive from circulating precursors, ...
In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy | Science Translational...
Plant Pathology. Plant nutrient acquisition entices herbivore. *. Working Life. The universe in a classroom ... Tumor-associated macrophages limit anti-PD-1 effects by removing the antibody from CD8+ T cells. ... Tumor-associated macrophages limit anti-PD-1 effects by removing the antibody from CD8+ T cells. ... Although anti-PD-1 antibodies initially bound to T cells as intended, the authors found that tumor-associated macrophages ...
Stories by JR Minkel - Scientific American
Growing plants without soil amongst frontier projects backed by President's fund | Imperial News | Imperial College London
Tumour imaging with nanoprobes. Dr Fang Xies team in the Department of Materials will develop nanoprobes to image deep tissue ... Growing plants without soil amongst frontier projects backed by Presidents fund. by Hayley Dunning, Caroline Brogan 26 March ... Plant roots naturally seek out water and nutrients, and grow according to gravity. The new materials would be embedded with ... Growing plants without soil. As the global population increases and climate change threatens traditional farming methods, ...
Injectable plant-based nanoparticles postpone progress of tumor
... to fill in as tumor tranquilize conveyance gadgets for mice. However, in a current article distributed… . ... Injectable plant-based nanoparticles postpone progress of tumor, Scientists from Case Western Reserve University School of ... Injectable plant-based nanoparticles postpone progress of tumor. ... into tumor destinations additionally helps stop tumor movement ... The analysts found infusing potato infection particles into melanoma tumor locales actuates a hostile to tumor invulnerable ...
Studying the Evolution of Tumors can Lead to Development of New Treatments Preventing Cancer Recurrence
Researchers have said that studying how tumors evolve can help the development of new treatments which can prevent the cancer ... Health Benefits of Dandelion Plant. What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health ... Carcinoid Tumors. Carcinoid tumors is a benign tumor that results in carcinoid syndrome. Only 8 to 10% of all carcinoid tumors ... Brain Tumor. Up to date information about brain tumor, the most common solid tumor in children and the third leading cause of ...
New Method That Traps Cancer Cells and Prevents the Growth of Secondary Tumors
By using experimental drugs scientists were able to stop fibroblasts from stiffening the tissue around tumors. Thus the healthy ... Health Benefits of Dandelion Plant. What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health ... Cancer Cells Disguise as Immune Cells to Spread Secondary Tumors in New Sites. The main reason why people die of cancer is that ... Tumors cause cells, called fibroblasts, to stiffen the surrounding tissue so that cancer cells can grip it. This allows them to ...
Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens | PNAS
... and demonstrate the high potency of extracts of these plants as chemoprotectors against experimental mammary tumors. ... Upper) Tumor incidence (percent of rats with tumors). (Lower) Tumor multiplicity (no. of tumors/no. of rats at risk). ... with respect to tumor multiplicity (tumors per animal), and incidence (fraction of tumor-bearing animals) (Fig. 5). The tumor ... Inhibition of Mammary Tumor Development in Rats.. Mammary tumors were produced in female Sprague-Dawley rats by feeding single ...
This Plant Is Everywhere, But You Had No Idea It Can Treat Tumors
The plant that we are going to talk about today is the mulberry herb. It originates from China but it can be found all across ... This Plant Is Everywhere, But You Had No Idea It Can Treat Tumors, Diabetes And High Blood Pressure!. ... The plant that we are going to talk about today is the mulberry herb. It originates from China but it can be found all across ... I AM 60 YEARS OLD AND THIS PLANT RETURNED MY VISION, REMOVED FAT FROM MY LIVER AND COMPLETELY CLEANED MY COLON ...
Translationally controlled tumorMiceProteinMouse tumorProgressionAnti-tumor effectApoptosisProliferationTissuesSuppressorPituitary glandVitroImmunotherapyGeneMammaryAbdominal tumorTctpNanoparticlesBreast tumorsInhibitionParticlesGenesChemotherapyTissueCellsGrowthSkin tumorsSolid tumorsEnhancing tumor immuneResearchersRate of tumorSilibininAnticancerMalignantMedicinalResistanceBenignHepatocellular carcinomaExtractsAntitumorMammalianMicroenvironmentMelanomaGallsAccumulationCell culturesHumanExtractPathwayTherapeuticTargetingGenomesAbstractRecombinantArabidopsisTreatment
Translationally controlled tumor11
- Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants. (nih.gov)
- Here, we address the biological role of Arabidopsis translationally controlled tumor protein (AtTCTP) and test its shared functions in animals and plants. (nih.gov)
- A cDNA encoding a homolog of human translationally controlled tumor protein (TCTP) was isolated from cotyledons of the short-day plant Pharbitis nil cv. (oup.com)
- In this study, we functionally characterized a rice translationally controlled tumor protein gene (Os11g43900, OsTCTP ) involved in Hg stress tolerance. (biomedcentral.com)
- Translationally controlled tumor protein (TCTP) is a highly conserved protein found in eukaryotes, across animal and plant kingdoms and even in yeast. (wikipedia.org)
- Translationally Controlled Tumor Protein (TCTP/tpt1) is a regulator of the cancer stem cell compartment, the tumor reversion program, tumor progression and certain forms of inflammatory diseases.Susini L et al. (wikipedia.org)
- Translationally Controlled Tumor Protein (TCTP) is a protein that in humans is encoded by the TPT1 gene. (wikipedia.org)
- Human translationally controlled tumor protein (hTCTP) is a growth-related, calcium-binding protein. (wikipedia.org)
- Translationally controlled tumor protein was first discovered in 1989 as a cDNA sequence obtained from a human mammary carcinoma cDNA library with proves derived from the translationally controlled, growth-related mouse tumor protein TCTP. (wikipedia.org)
- Translationally-controlled tumor protein has a role in tumor reversion and development. (wikipedia.org)
- Translationally Controlled Tumor Protein (TCTP) is involved in a wide range of molecular interactions with biological and nonbiological partners of various chemical compositions such as proteins, peptides, nucleic acids, carbohydrates, or small molecules. (wikipedia.org)
Mice20
- Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice. (nih.gov)
- Here, we present a detailed analysis of PVX biodistribution and clearance in healthy mice and mouse tumor xenograft models using a combination of ex vivo whole-organ imaging, quantitative fluorescence assays and immunofluorescence microscopy. (nih.gov)
- After silibinin treatment, tumour cells resumed normal ACTH production, tumour growth slowed down and symptoms of Cushing Disease disappeared in mice. (daily-sun.com)
- Triple-negative breast cancer tumors of mice treated with the phenanthriplatin -carrying nanoparticles were four times smaller than those treated either with cisplatin, a common and related chemotherapy drug, or free phenanthriplatin injected intravenously into circulation. (teknoscienze.com)
- In vivo anti-tumor activity was evaluated in nude mice bearing subcutaneously human Ando-2 melanoma cells. (biomedcentral.com)
- The intraperitoneal injection or oral administration of LACE extract in nude mice inhibits in vivo tumor growth of Ando-2 melanoma cells and prolongs the survival day of the mice. (biomedcentral.com)
- The LACE extract presented in vivo anti-tumoral activity in nude mice against tumor growth of Ando-2 melanoma cells. (biomedcentral.com)
- Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice. (mysciencework.com)
- Scientists from Case Western Reserve University School of Medicine as teams with analysts from Dartmouth Geisel School of Medicine and RWTH Aachen University (Germany) have adjusted infection particles - that regularly taint potatoes - to fill in as tumor tranquilize conveyance gadgets for mice. (health11.com)
- What's more, at the same time infusing the nanoscale plant infection particles and chemotherapy sedate - doxorubicin - into tumor destinations additionally helps stop tumor movement in mice. (health11.com)
- The results are the first to indicate "inoculating" mice with potato infection nanoparticles at a growth site can create a hostile to tumor reaction. (health11.com)
- Consumption of the inulin gel expanded and increased the number of beneficial microbes in tumor-bearing mice," said Kai Han, postdoctoral fellow and first author of the study. (amazinghealthadvances.net)
- Silencing of HoxA1 with nanoparticle siRNA prevented loss of hormone receptor expression, suppressed cell proliferation, and reduced mammary tumor incidence in mice. (sciencemag.org)
- When transplanted into mice, tumor genomes evolve differently than they do in patients, study finds. (the-scientist.com)
- An HCC model was established in H22 tumor-bearing mice and triterpenoid saponins were administered at various doses. (dovepress.com)
- Human tumors transplanted into laboratory mice disappeared or shrank when scientists treated the animals with a single antibody, according to a new study from the Stanford University School of Medicine. (medicalxpress.com)
- Berger DP, Winterhalter BR and Fiebig HH (1992) Establishment and characterization of human tumor xenografts in thymus aplastic nude mice. (nature.com)
- In a study reported in the team's Cancer Research paper, tumors in mice that received an intravenous injection of nanorods plus near-infrared laser treatment disappeared within 15 days. (phys.org)
- It also inhibited the growth of S-180 tumor to 49% of the control at the dose of 200 mg kg(-1) d(-1) and extended the survival time of the tumor-bearing mice. (nih.gov)
- C57BL/6 mice immunized with E7-containing crude foliar extracts developed both humoral and cell-mediated immune responses and were protected from tumor development after challenge with the E7-expressing C3 tumoral cell line. (elsevier.com)
Protein18
- No AtTCTP protein accumulation is observed in tctp -1 and tctp -2 plants. (nih.gov)
- In their experiments the researchers found tremendously high amounts of the heat shock protein 90 (HSP90) in tumour tissue from patients with Cushing Disease. (daily-sun.com)
- Here we show that moderate activation of the pathway conferred either by mutation in the Gα subunit or by mutation in the regulatory subunit of the protein kinase A influences tumor morphology. (apsnet.org)
- Human isoforms of the p53 protein play a key role in maintaining genetic stability, functioning as active tumour suppressors. (europeanpharmaceuticalreview.com)
- The main effect of this binding is that, firstly, the protein loses its function 1 and, secondly, it becomes an oncoprotein that promotes tumour formation and metastasis 3 . (europeanpharmaceuticalreview.com)
- These studies suggest that protein Tyr (de)phosphorylation performs critical functions in plants. (plantcell.org)
- L1 protein was detected in concentrated plant extracts at concentrations up to 1.0 mg/kg in transgenic plants and up to 0.4 mg/kg in TMV-infected plants. (asm.org)
- by generating a fusion protein of CCL4 and the collagen-binding domain (CBD) of von Willebrand factor, we show that CBD fusion enhances CCL4 tumor localization. (sciencemag.org)
- The translationally controlled tumour protein, commonly known as TCTP, is a highly conserved protein among many eukaryotic organisms. (wikipedia.org)
- The Mammalian translationally controlled tumour protein (TCTP) (or P23) is a protein which has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. (wikipedia.org)
- TCTP was originally described as a growth related protein of tumor cells. (wikipedia.org)
- Research in 1997 shown that TCTP is not a tumor- or tissue-specific protein, but is expressed ubiquitously from plants to mammals. (wikipedia.org)
- Expression levels of TCTP were down-regulated at the mRNA and protein levels during tumor suppression and by the activation of p53 and Siah-1 very well known anti-tumor genes. (wikipedia.org)
- While damaging healthy cells is an inevitable process through most cytotoxic drugs, chemotherapy also triggers them to secrete a protein that sustains tumour growth and resistance to further treatment. (healthyaeon.com)
- p53 protein functions as a sequence-specific transcription factor and its tumor suppressor function is attributed to its ability to regulate gene expression. (biologists.org)
- Heat shock protein 70 is an antiapoptotic chaperone protein highly expressed in human breast tumors and tumor cell lines. (pnas.org)
- Despite the apoptotic morphology as judged by electron microscopy, the asHsp70-induced death was independent of known caspases and the p53 tumor suppressor protein. (pnas.org)
- In this study, we describe for the first time the expression of the human papillomavirus 16 E7 protein in Nicotiana benthamiana plant using a potato virus X-derived vector. (elsevier.com)
Mouse tumor1
- The anti-tumor activity of HTCP in the mouse tumor model was not correlated with immunomodulation and galectin-3 inhibition, but correlated well with proliferation inhibition. (nih.gov)
Progression4
- These results show that molecular analyses of patient samples can add to the information about the tumor and help us in tracking back the progression of the disease," the authors concluded. (medindia.net)
- The ability of tumors to evade being recognized by the immune system plays a critical role in cancer progression. (genengnews.com)
- Using mouse models of breast cancer and melanoma, they show that loss of the Type III TGF-β receptor (TGFBR3) in tumors promotes cancer progression by altering signaling in tumor-associated immune cells. (genengnews.com)
- Impaired apoptosis signaling is common in cancer cells and may play an important role in tumor initiation and progression ( 1 - 4 ). (pnas.org)
Anti-tumor effect3
- It has been recognized all over the world and plant polysaccharides have anti-tumor effect through their immunomodulating effect on the organisms which carried tumor. (cnki.com.cn)
- In this study, we evaluated the in vitro cytotoxic anti-tumor and immunomodulatory activities and in vivo anti-tumor effect of Laser Activated Calendula Extract (LACE), a novel extract of the plant Calendula Officinalis (Asteraceae) . (biomedcentral.com)
- MCP had no anti-proliferative effects on these cancer cells and no anti-tumor effect in the mouse model. (nih.gov)
Apoptosis9
- Furthermore, the N-terminal domain of TCTP inhibits apoptosis by binding to apoptotic factors and by inhibiting p53 tumour suppressor-dependent apoptosis by downregulating it. (wikipedia.org)
- Furthermore, Bcl-2 and Bcl-X L , which protect tumor cells from most forms of apoptosis, failed to rescue breast cancer cells from asHsp70-induced death. (pnas.org)
- Resistance of cancer cells to apoptosis is especially deleterious because it not only enhances the spontaneous growth of tumors but also renders them resistant to host defense mechanisms as well as various forms of therapy. (pnas.org)
- Interestingly, Hsp70 rescues cells from apoptosis induced by, e.g., tumor necrosis factor (TNF), without inhibiting the activation of effector caspases ( 19 ). (pnas.org)
- In addition to its preferential expression in tumors and its ability to inhibit apoptosis, the role of Hsp70 in tumorigenesis is supported by data showing that its expression enhances the tumorigenic potential of rodent cells in vivo ( 20 - 22 ). (pnas.org)
- Earlier results of a preliminary nature have suggested that the inhibition of Hsp70 synthesis in tumor cells may either sensitize them to chemotherapy or commit them to apoptosis ( 19 , 27 , 28 ). (pnas.org)
- In addition, triterpenoid saponins inhibited tumor growth and induced the apoptosis of HCC cells by blocking the activation of PD1/PD-L1, ERK1/2, p38 MAPK, JNK, and STAT3 signaling pathways. (dovepress.com)
- Studies have show that ursolic acid suppresses tumor formation, inhibits tumor growth, induces apoptosis, inhibits angiogenesis, inhibits signaling and activation pathways, induces tumor cell differentiation, and suppresses growth factor expression. (essense-of-life.com)
- When chronically applied to the skin, they supposedly would not damage normal skin cells or negatively affect their functions while they would suppress tumorigenic cell transformation, inhibit tumor cell proliferation, and activate tumor cell apoptosis. (elsevier.com)
Proliferation6
- A localized proliferation of plant tissue forming a swelling or outgrowth, commonly with a characteristic shape and unlike any organ of the normal plant. (harvard.edu)
- Consistent with this finding, plant AtTCTP can fully rescue cell proliferation defects in Drosophila loss of function for dTCTP. (nih.gov)
- These results indicate that some inhibitors of plant cell division are capable of inhibiting the proliferation of animal tumor cells. (aacrjournals.org)
- Tumor cell lines derived from leukemias, melanomas, fibrosarcomas and cancers of breast, prostate, cervix, lung, pancreas and colorectal were used and tumor cell proliferation in vitro was measured by BrdU incorporation and viable cell count. (biomedcentral.com)
- The LACE extract showed a potent in vitro inhibition of tumor cell proliferation when tested on a wide variety of human and murine tumor cell lines. (biomedcentral.com)
- Ursolic acid demonstrated a significant inhibition of the proliferation of cultured tumour cells. (essense-of-life.com)
Tissues10
- While up to 30% of the PVX signal was from the colon, mammary and brain tumor tissues, remaining particles were cleared by the reticuloendothelial system organs (the spleen and liver), followed by slower processing and clearance through the kidneys and bile. (nih.gov)
- Cell walls from normal and tumor tissues in culture also show this difference, indicating that the two types of tissue stably maintain this difference under these conditions. (sciencemag.org)
- Crown-gall tumors thus resemble embryonic tissues in this respect. (sciencemag.org)
- We assumed that in these tissues, the genes involved in plant differentiation could be induced or repressed, and thus current project is directed to isolation and characterization of such genes. (nii.ac.jp)
- Sulforaphane induces several phase 2 enzymes in both cultured cells and mouse tissues ( 15 ), blocks 7,12-dimethylbenz( a )anthracene (DMBA)-initiated mammary tumor formation in rats ( 16 ), and inhibits neoplastic nodule formation in cultured mouse mammary glands ( 17 ). (pnas.org)
- OsTCTP was ubiquitously expressed in all examined plant tissues, especially in actively dividing and differentiating tissues, such as roots and nodes. (biomedcentral.com)
- Immunofluorescence, flow cytometry, and western blot were performed to analyze the effect of triterpenoid saponins on immune response in tumor tissues. (dovepress.com)
- Metabolomic analysis was carried out to assess the metabolites involved in mediating the effect of triterpenoid saponins on tumor tissues. (dovepress.com)
- However, it's difficult to heat patients' tumors without damaging nearby tissues. (phys.org)
- Another advantage of the nanorods is that by coating them with different types of light-scattering molecules, they can be designed to simultaneously gather multiple types of information - not only whether there is a tumor, but whether it is at risk of invading other tissues, whether it's a primary or secondary tumor, or where it originated. (phys.org)
Suppressor2
- The p53 gene is one of the most intensively studied tumour suppressor genes. (europeanpharmaceuticalreview.com)
- Here, we describe the functional analysis of an Arabidopsis gene ( AtPTEN1 ) that encodes a Tyr phosphatase closely related to PTEN, a tumor suppressor in animals. (plantcell.org)
Pituitary gland4
- Cushing Disease is caused by a tumour in the pituitary gland in the brain. (daily-sun.com)
- Alpine skier Hailey Duke is paying her own expenses to pursue a spot on the U.S. Olympic team following surgery to remove a benign tumor from her pituitary gland. (thestar.com)
- Brain surgery was looming to remove a tumour that was attached to her pituitary gland. (thestar.com)
- Through a routine blood test last fall, doctors found increased levels of prolactin in her system, indicating the possible presence of a tumour on her pituitary gland. (thestar.com)
Vitro7
- A ) Homozygous tctp -1 and tctp -2 embryos rescued by nutrient supplements in vitro develop into adult plants. (nih.gov)
- In this review, the in vitro and in vivo effects of two medicinal, phytochemical-producing plants that were obtained from Adekunle Ajasin University's botanical garden are discussed. (europeanpharmaceuticalreview.com)
- An aqueous extract of Calendula Officinalis was obtained by a novel extraction method in order to measure its anti-tumor and immunomodulatory activities in vitro . (biomedcentral.com)
- These results indicate that LACE aqueous extract has two complementary activities in vitro with potential anti-tumor therapeutic effect: cytotoxic tumor cell activity and lymphocyte activation. (biomedcentral.com)
- The aim of the present study was to evaluate the in vitro cytotoxic anti-tumor and immunomodulatory activities of a novel extract of the plant Calendula Officinalis (LACE: Laser Activated Calendula Extract). (biomedcentral.com)
- Arabidopsis plants grown in vitro in CRAG's growth chambers. (cragenomica.es)
- The fourth part, containing investigative information on almost 300 individual plant species with established anticancer properties, either on a clinical or in vitro level, is with no doubt the most analytical. (routledge.com)
Immunotherapy3
- The altered glycosylation of MUC1 reveals an immunodominant peptide along its tandem repeat (TR) that has been used as a target for tumour immunotherapy. (mysciencework.com)
- Intravenous CBD-CCL4 administration recruits CD103 + DCs and CD8 + T cells and improves the antitumor effect of CPI immunotherapy in multiple tumor models, including poor responders to CPI. (sciencemag.org)
- The researchers concluded that if TGF-β expression is inhibited, this would provide a novel method of tumor immunotherapy and that "sTGFBR3 levels could serve as a predictive immunotherapy biomarker. (genengnews.com)
Gene15
- The most promising way to exploit plant RIPs as weapons against cancer cells is either by designing molecules in which the toxic domains are linked to selective tumor targeting domains or directly delivered as suicide genes for cancer gene therapy. (mdpi.com)
- Tumour suppression gene products are produced by cells to monitor the efficiency of the cell cycle by populating specific phases in the process of both DNA and cell replications 1 . (europeanpharmaceuticalreview.com)
- RNA gel blot analysis and examination of promoter-reporter constructs in transgenic Arabidopsis plants revealed that the AtPTEN1 gene is expressed exclusively in pollen grains during the late stage of development. (plantcell.org)
- We first generated shoot-forming and unorganized calli in tobacco plants upon introduction of auxin and cytokinin biosynthesis genes, and 6b gene which modulates the effects of these plant growth substances. (nii.ac.jp)
- Finally, the psaB and ribonucleoprotein gene seem to be required for chloroplast development, and further investigation is necessary to determine the relationship between plastid and total plant development. (nii.ac.jp)
- Analysis of his tumors following surgeries, biopsies and autopsy revealed several genetic aberrations, including multiple copies of a region on chromosome 4q, which includes the KIT gene. (medindia.net)
- Additional findings included the loss of the gene PKP4, which is associated with increased tumor size. (medindia.net)
- Join this webinar to learn how spatial resolution of gene expression in tumor tissue reveals new insights in biomarker discovery and therapeutic response. (genomeweb.com)
- A new study has shown that survival rates among patients with glioma double if the tumor carries a methylated MGMT gene. (news-medical.net)
- Moreover, in lower plants it is phytochrome that steers growth direction - that simply can't be done via gene regulation. (innovations-report.com)
- Bayer's new Vitrakvi for tumors with NTRK gene fusions is meeting skepticism in England and Germany, where cost watchdogs on Friday rejected it. (fiercepharma.com)
- 1983), "A chimaeric antibiotic resistance gene as a selectable marker for plant cell transformation," Nature 304:184-187. (freepatentsonline.com)
- 1983) "Multiple Viral Specific Transcripts from the Genome of Cauliflower Mosaic Virus," Proceedings of the Miami Winter Symposium, Jan. 1983, published in Advances in Gene Technology: Molecular Genetics of Plants and Animals (Ahmad et al. (freepatentsonline.com)
- 1983) "Ti and Ri Plasmids as Vectors for Genetic Engineering of Higher Plants," Proceedings of the Miami Winter Symposium, Jan. 1983, published in Advances in Gene Technology: Molecular Genetics of Plants and Animals (Ahmad et al. (freepatentsonline.com)
- NEWS, 26 March 2010] Gene therapy on a tomato gene could be of value in future treatment of brain tumors, according to a new study from Karolinska Institutet and Lund University. (ki.se)
Mammary2
- Glucosinolates and isothiocyanates can be efficiently extracted from plants, without hydrolysis of glucosinolates by myrosinase, by homogenization in a mixture of equal volumes of dimethyl sulfoxide, dimethylformamide, and acetonitrile at −50°C. Extracts of 3-day-old broccoli sprouts (containing either glucoraphanin or sulforaphane as the principal enzyme inducer) were highly effective in reducing the incidence, multiplicity, and rate of development of mammary tumors in dimethylbenz( a )anthracene-treated rats. (pnas.org)
- TCTP knockdown in primary mammary tumor cells, results in increased p53 expression and a decreased number of stem-like cancer cells. (wikipedia.org)
Abdominal tumor1
- A massive abdominal tumor measuring about 10 kg has been removed from a female patient, by surgeons in the western Croatian town of Gospic. (medindia.net)
Tctp6
- We show that, in contrast to animal TCTP, plant AtTCTP is not implicated in regulating postmitotic growth. (nih.gov)
- Our data provide evidence that TCTP function in regulating cell division is part of a conserved growth regulatory pathway shared between plants and animals. (nih.gov)
- A ) Siliques produced by WT or by heterozygous AtTCTP/tctp -1 and AtTCTP/tctp -2 plants. (nih.gov)
- B ) Semiquantitative RT-PCR analysis showing no expression of AtTCTP in leaves of both tctp -1 and tctp -2 plants. (nih.gov)
- C ) Western blot analysis of AtTCTP accumulation in leaves of WT, tctp -1, and tctp -2 plants using anti-AtTCTP antibody. (nih.gov)
- Down-regulation of TCTP can induce tumor reversion, and in combination with some drugs that decrease the level of TCTP and will lead to kill tumor cells. (wikipedia.org)
Nanoparticles4
- Nanoparticles based on plant viruses are emerging biomaterials for medical applications such as drug delivery and imaging. (nih.gov)
- The long, thin tobacco mosaic virus nanoparticles are naturals for delivering the drug candidate into tumors, said Steinmetz, who was appointed by the Case Western Reserve School of Medicine. (teknoscienze.com)
- Inside tumors, the nanoparticles gather inside the lysosomal compartments of cancer cells, where they are, in essence, digested. (teknoscienze.com)
- The projects, which aim to grow plants without soil, teach computers to check mathematical proofs, and use nanoparticles for cancer detection, will each receive £250,000 for three years. (imperial.ac.uk)
Breast tumors1
- NEW YORK (GenomeWeb News) - Researchers from the US and Canada reported online in Nature yesterday that they have successfully used single-cell sequencing to discern copy number patterns in individual cells from primary and metastatic breast tumors. (genomeweb.com)
Inhibition2
- CV extracts showed antiprolife-rative and proapoptotic effects in all MTC and SI-NET cell lines, whereby high growth inhibition was observed by treatment with the ethylacetate-extracts (CV-45) in tumor cell lines but not in normal human fibroblasts. (spandidos-publications.com)
- Marko D, Schätzle S, Friedel A, Genzlinger A, Zankl H, Meijer L and Eisenbrand G (2001) Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells. (nature.com)
Particles6
- The analysts found infusing potato infection particles into melanoma tumor locales actuates a hostile to tumor invulnerable framework reaction. (health11.com)
- At the point when the plant-based infection particles and the medications could take a shot at their own, we saw the best benefit. (health11.com)
- Steinmetz and her group will next research instruments behind the potato infection particles' hostile to tumor impacts. (health11.com)
- Now, MIT researchers have developed tiny gold particles that can home in on tumors, and then, by absorbing energy from near-infrared light and emitting it as heat, destroy tumors with minimal side effects. (phys.org)
- This class of particles provides the most efficient method of specifically depositing energy in tumors," he said. (phys.org)
- In designing the particles, the researchers took advantage of the fact that blood vessels located near tumors have tiny pores just large enough for the nanorods to enter. (phys.org)
Genes4
- This article aims at reviewing the current advances in p53 research, as well as discussing the possibilities of inhibiting the expression and activity of mutant p53 genes in human malignancies through the use of medicinal plants. (europeanpharmaceuticalreview.com)
- By analysing the expression of cell cycle genes in the Arabidopsis leaves, the researchers discovered that several of these genes had altered oscillations in plants with high accumulation of TOC1. (cragenomica.es)
- Not surprisingly, it has been found that very many plant genes are regulated by phytochrome, and indeed most textbooks say that phytochrome works exclusively in this manner. (innovations-report.com)
- This invention relates to chimeric genes which are capable of being expressed in plant cells. (freepatentsonline.com)
Chemotherapy8
- Neuroendocrine tumors respond poorly to radiation and conventional chemotherapy, hence surgical removal of the neoplastic tissue is still the most effective way of treatment. (spandidos-publications.com)
- The patient in the study received conventional treatment, which included surgical removal of his tumors, radiation therapy and chemotherapy, and participation in a clinical trial. (medindia.net)
- 4. Anti-tumor and anti radiation, inhibit tumor growth,prevent postoperative recurrence,reduce side-effects during chemotherapy or radiotherapy, such as mitigate the pains,suppress hair loss, etc. (plantbased-powder.com)
- Most of those patients are treated with chemotherapy and/or radiation, which are often effective but can have debilitating side effects because it's difficult to target tumor tissue. (phys.org)
- With chemotherapy treatment, 99 percent of drugs administered typically don't reach the tumor, said von Maltzahn. (phys.org)
- Additionally, heating them to a lower temperature weakens tumor cells enough to enhance the effectiveness of existing chemotherapy treatments, raising the possibility of using the nanorods as a supplement to those treatments. (phys.org)
- The Gynecologic Oncology Group (GOG) is currently conducting a randomized phase II trial (Clinical trial ID: NCT104522) comparing BEP with carboplatin and paclitaxel for patients with advanced or recurrent chemotherapy-naive sex cord stromal tumors. (medscape.com)
- The second part is a brief journey in pharmacognosy, with detailed information about each of the fourteen different chemical groups of plant secondary metabolites, their use in cancer chemotherapy, and updated information on the biotechnological production of the most representative compounds in clinical practice. (routledge.com)
Tissue5
- Scientists around Gunter Stalla, endocrinologist at the Max Planck Institute of Psychiatry in Munich, have discovered in cell cultures, animal models and human tumour tissue that a harmless plant extract can be applied to treat Cushing Disease. (daily-sun.com)
- As there are too many HSP90 molecules in the tumour tissue, they stick to the glucocorticoid receptor," said Paez-Pereda. (daily-sun.com)
- Habituated tissue cultures, which resemble crown-gall tumor cultures, however, form cell walls that are inhibitory like those of the normal cultures from which they are derived. (sciencemag.org)
- A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. (innovations-report.com)
- Any tissue that lights up, other than the liver or spleen, could harbor an invasive tumor. (phys.org)
Cells29
- Ricin, the plant RIP prototype that comprises a catalytic A subunit linked to a galactose-binding lectin B subunit to allow cell surface binding and toxin entry in most mammalian cells, shows a potency in the picomolar range. (mdpi.com)
- Neuroendocrine tumors (NETs) represent rare tumors that are derived from cells of the embryonic neural crest. (spandidos-publications.com)
- MTCs are calcitonin producing tumors arising from the parafollicular C-cells and occur in ~4-10% of all thyroid tumors ( 2 ). (spandidos-publications.com)
- In a previous study, pheophorbid-a, a chlorophyll derivative in Christia vespertilionis plant extracts showed high antiproliferative activity in MTC cells ( 13 ). (spandidos-publications.com)
- Although it is well known that Tyr phosphatases play a critical role in signal transduction in animal cells, little is understood of the functional significance of Tyr phosphatases in higher plants. (plantcell.org)
- Although both Ser/Thr and Tyr phosphorylation play a crucial role in cellular regulation in animal systems, only Ser/Thr phosphorylation has been established as an important regulatory mechanism in plant cells. (plantcell.org)
- The normal immunity system can identify and kill tumor cells, however, the occurrence rate of tumor will enhance if it lacks of the ability of immunologic defence or immunological recognition. (cnki.com.cn)
- The elongated shape of the nanoparticle causes it to tumble along the margins of blood vessels, remain unnoticed by immune cells and pass through the leaky vasculature of tumors and accumulate inside. (teknoscienze.com)
- Although anti-PD-1 antibodies initially bound to T cells as intended, the authors found that tumor-associated macrophages quickly removed these antibodies from T cells, thus inactivating them. (sciencemag.org)
- Myrosinase (see ref. 18 ) is normally segregated from glucosinolates and is released when plant cells are injured. (pnas.org)
- When we counted the number of cells in the leaves of the plants that overexpress TOC1, we saw that there were fewer cells, which suggested that by modifying the circadian clock, we were also modifying the cell division pace ", explains Jorge Fung, pre-doctoral student and first author of the work. (cragenomica.es)
- The cells of the plants that overexpress TOC1 remain longer at the G1 phase, failing to enter the S phase at the appropriate time " says Jorge Fung. (cragenomica.es)
- The composition of tumor-infiltrating immune cells has been identified as a key factor influencing CPI therapy success. (sciencemag.org)
- A lack of the chemokine CCL4 within the tumor microenvironment leads to the absence of CD103 + dendritic cells (DCs), a crucial cell population influencing CPI responsiveness. (sciencemag.org)
- The scientists say their study also supports the use of TGF-β inhibitors to enhance the efficacy of therapies that promote immune-mediated elimination of tumor cells. (genengnews.com)
- Work with the murine models demonstrated that the loss of tumor-expressed TGFBR3/sTGFBR3 enhanced TGF-β signaling within locoregional dendritic cells (DC). (genengnews.com)
- SAN FRANCISCO (GenomeWeb) - Tumor sequencing tests may pick up not only somatic mutations found in the tumor but also a certain class of non-cancerous mutations that accumulate in hematopoietic stem cells and are associated with age, according to a recent study published by researchers from Rutgers University and Foundation Medicine. (genomeweb.com)
- Brucea javanica (Brucea javanica (L.) Merr) is one of those plants that needs far more recognition in this catergory for its incredible ability to selectively kill cancer cells. (healthyaeon.com)
- Hsp70 is abundantly expressed in malignant human tumors of various origins, whereas in normal cells, its expression is mainly stress inducible. (pnas.org)
- Triterpenoid saponins induced anti-tumor immune response by decreasing the number of Treg cells, increasing that of B cells, natural killer cells, and CD3 + /CD28 + T cells, and reducing the secretion of inflammatory factors including nuclear factor-κB, cyclooxygenase-2, and microsomal prostaglandin E synthase-1. (dovepress.com)
- The treatment of cancer with chemotherapeutic agents and radiation has two major problems: tumor resistance to therapy and toxicity toward normal cells. (essense-of-life.com)
- Recent research has suggested that plant polyphenols (which includes ursolic acid) might be used to sensitize tumor cells to chemotherapeutic agents and radiation therapy by inhibiting pathways that lead to treatment resistance. (essense-of-life.com)
- PhysOrg.com) -- It has long been known that heat is an effective weapon against tumor cells. (phys.org)
- During a single exposure to a near-infrared laser, the nanorods heat up to 70 degree Celsius, hot enough to kill tumor cells. (phys.org)
- The nanorods could also be used to kill tumor cells left behind after surgery. (phys.org)
- 1977) "T-DNA from Agrobacterium Ti plasmid is in the nuclear DNA fraction of crown gall tumor cells," Proc. (freepatentsonline.com)
- 1982) "Agrobacterium rhizogenes inserts T-DNA into the genomes of the host plant root cells," Nature 295:432-434. (freepatentsonline.com)
- The reproductive success of seed plants is performed and based on the invention of the pollen tube, an extension of the pollen grain that is produced under favorable conditions and that allows the sperm cells to move from the male gametophyte towards the female one. (mdpi.com)
- From a pure biological point of view, the pollen tube is an atypical plant cell, because it grows by a tip-growing mechanism, rather than by the typical diffuse way of somatic cells. (mdpi.com)
Growth14
- The data support a role of plant AtTCTP as a positive regulator of mitotic growth by specifically controlling the duration of the cell cycle. (nih.gov)
- The study also suggests that, although the cell division machinery is shared in all multicellular organisms to control growth, cell expansion can be uncoupled from cell division in plants but not in animals. (nih.gov)
- Instead of the roots aligning their growth to gravity, the team also plan to make use of electrotropism - where plant roots align with external electric fields. (imperial.ac.uk)
- Now, a research team from the Centre for Research in Agricultural Genomics (CRAG), led by the CSIC researcher Paloma Mas, has shown, for the first time in plants, that the circadian clock controls the speed of the cell cycle and, consequently, regulates the cell division and growth in synchronization with the day and night cycles. (cragenomica.es)
- Reishi mushroom can also lower cholesterol, prevent blood clots, help prevent the growth of tumors, and increase the body's ability to fight unwanted invaders. (plantbased-powder.com)
- Mercury (Hg) is not only a threat to public health but also a growth risk factor to plants, as it is readily accumulated by higher plants. (biomedcentral.com)
- Plants have provided a new avenue in curbing tumor growth. (news-medical.net)
- Schmidt have exhibited anti-cancer properties and exerted remarkable inhibitory effects on tumor growth. (dovepress.com)
- Generally, plants adjust their growth to fit in with their local environment, light being easily the most important factor - after all, they need light to live. (innovations-report.com)
- Whereas phototropin somehow steers growth direction in higher plants, phytochrome controls most aspects of plant development including germination, stem extension, greening and even flowering. (innovations-report.com)
- Though population growth and rising demand for resources as more of the world enters into consumeristic lifestyles both play a part in the rising amount of plant life consumed, as this chart shows, on a global basis rising per capita increases in consumption have far outpaced the influence of population growth. (treehugger.com)
- Topical application of ursolic acid inhibited TPA-induced initiation and promotion of tumor growth. (essense-of-life.com)
- This study suggests for the first time the ability of S. perfoliata, S. thymbra, S. officinalis, L. nobilis and P. palestina essential oils and some identified terpenes to inhibit human tumor cell growth. (nih.gov)
- A gardener explains that growing lavender plants requires planting them in good compost or potting soil, putting them in a place with full, hot sun and trimming them back in the fall for a lush growth the following spring. (nottingham.ac.uk)
Skin tumors4
- A phlorogrucinol-monoterpene derivative, euglobal-G1, obtained from leaves of E. grandis exhibited a remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[ α ]anthracene [ 6 ]. (hindawi.com)
- As the incidence of skin tumors has been steadily growing, there is an urgent need for the preventive measures as well as the improved therapeutic approaches. (elsevier.com)
- The major aim of this critical review is to provide recent updates on the molecular and cellular targets for the prevention and therapy of skin tumors with a special focus on the crossroad between inflammation and carcinogenesis as the most promising approach to chemoprevention. (elsevier.com)
- The feasibility of PPs to prevent/ cure specific cutaneous toxicity connected to anti-EGFR therapy and to reduce multidrug resistance of skin tumors is also discussed. (elsevier.com)
Solid tumors2
- Testicular germ cell cancer, a disease that is rare but growing in incidence in men in the United States, is considered to be among the most curable of solid tumors. (news-medical.net)
- Scientists at the Genome Institute of Singapore (GIS) have unraveled the mechanism that causes liver cancer (hepatocellular carcinoma, HCC), one of the most common solid tumors worldwide. (medicalxpress.com)
Enhancing tumor immune1
- Thus, enhancing tumor immune cell infiltration is a critical challenge. (sciencemag.org)
Researchers7
- In a pair of firsts, researchers at Case Western Reserve University and Massachusetts Institute of Technology have shown that the drug candidate phenanthriplatin can be more effective than an approved drug in vivo, and that a plant-virus-based carrier successfully delivers a drug in vivo. (teknoscienze.com)
- The researchers say delivery of the phenanthriplatin into the tumor led to its improved performance over cisplatin or free phenanthriplatin. (teknoscienze.com)
- Researchers at Translational Genomics Research Institute (TGen) and Scottsdale Healthcare said that studying how tumors evolve can help the development of new treatments which can prevent the cancer from recurring. (medindia.net)
- TGen researchers tracked several years of tumor evolution in a 47-year-old male patient with maxillary sinus carcinoma (MSC), a rare cancer of the sinus cavities beneath the cheeks that often requires surgical removal that is disfiguring. (medindia.net)
- To reveal how the circadian clock controls the cell cycle, the researchers analysed the duration of each cell cycle phase in the leaves of plants that overexpress TOC1 and compared it with control plants. (cragenomica.es)
- This increase stems from higher plant colonization rates and lower extinction rates in connected versus unconnected fragments, researchers report in the Sept. 27 Science . (sciencenews.org)
- Every tumor is different, which is why Bayer researchers are working on new, personalized forms of treatment which will use small molecules to target the causes of cancer. (wczasy-egipt.com)
Rate of tumor1
- For instance, when inulin gel was combined with an immune checkpoint inhibitor in a colon carcinoma rodent model, the rate of tumor eradication doubled (100% improvement), compared with the immune checkpoint inhibitor therapy alone. (amazinghealthadvances.net)
Silibinin1
- In the last two decades, natural plant derived polyphenols (PPs, resveratrol, silibinin, green tea polyphenols, flavonoids, anthocyanins, etc.) have been drawing particular interest as emerging active substances in dermatological/ cosmeceutical compositions for the prevention, slowing, or reversion of skin tumorigenesis (chemoprevention). (elsevier.com)
Anticancer3
- The results indicate that Christia vespertilionis could serve as an anticancer therapeutic for treatment of neuroendocrine tumors. (spandidos-publications.com)
- Roth T, Burger AM, Dengler W, Willmann H and Fiebig HH (1999) Human tumor cell lines demonstrating the characteristics of patient tumors as useful models for anticancer drug screening. (nature.com)
- Our data support the possibility of producing a cost-effective anticancer vaccine in plant with intrinsic adjuvant-like properties. (elsevier.com)
Malignant2
- Tumors can be benign (unlikely to spread to other body parts) or malignant (likely to spread). (thefreedictionary.com)
- 5/18/2015, Fukushima prefectural government announced they found malignant or possible malignant thyroid tumor from 127 children so far. (fukushima-diary.com)
Medicinal9
- In the following paragraphs we explore how the specific phytochemicals from medicinal plants can be used in either preventing the formation of mutant p53, or shutting down the activities of mutant p53 in the metastasis of malignancies. (europeanpharmaceuticalreview.com)
- Beyond limited empirical observations, not all medicinal plants have established scientific studies to support their effectiveness. (healthyaeon.com)
- The effectiveness of medicinal plants and foods to treat cancer is perhaps receiving the most widespread attention. (healthyaeon.com)
- The results demonstrate the cytotoxic potential of the B. albiflora hexanic fraction and substantiate the importance of the study of the traditional Mayan medicinal plants. (hindawi.com)
- Together with what was previously described, the traditional medicine of the indigenous pueblos was recognized by the World Health Organization (WHO), which caused a powerful drive toward the research of medicinal plants [ 1 ]. (hindawi.com)
- 147. Antineoplastic alkaloids from Chinese medicinal plants and their analogs. (nature.com)
- Ursolic acid is a compound that exists widely in food, medicinal herbs and other plants. (essense-of-life.com)
- Medicinal aromatic plants belong to a big plant group with a great interest due to its pharmaceutical, cosmetic and nutritional application. (nottingham.ac.uk)
- Bolivia-Kallawayan medicinal plants as leads to anti-HIV, anti-tumor and other potential drugs / by Qi Jia. (tcu.edu)
Resistance1
- Modulation of distinct signaling elements can generate plants with improved stress resistance. (oup.com)
Benign1
- The condition was clinically diagnosed as a right-sided benign tumor of the vastus lateralis muscle. (who.int)
Hepatocellular carcinoma1
- The Occlusin 500 Artificial Embolization Device (OCL 500) is a microspherical embolization agent approved for the treatment of highly vascularized, unresectable tumors, e.g., hepatocellular carcinoma or renal cell carcinoma. (medgadget.com)
Extracts6
- In an attempt to find new therapeutic plant extracts of Christia vespertilionis (CV) their antitumor potential in human medullary thyroid carcinoma (MTC) and human small intestinal neuroendocrine tumor (SI-NET) cell lines were tested. (spandidos-publications.com)
- Remarkably, isoquinoline alkaloids, usually typical for Papaveraceae or closely related families, were found in Christia plant extracts. (spandidos-publications.com)
- We carried out the methanolic extracts of different parts of the plant by means of extraction with the Soxhlet equipment. (hindawi.com)
- Prior studies have demonstrated that the extracts of plants utilized in the traditional Mayan medicine for the treatment of the signs and symptoms suggestive of cancer possess cytotoxic activity [ 6 ]. (hindawi.com)
- It is expected to provide basic knowledge and skills related to production and chemical features of essences and extracts from local plants in Iberian Peninsula. (nottingham.ac.uk)
- The tumors appear to be dying and then healing after treatment with cannabis-based extracts. (theweedblog.com)
Antitumor1
- In general, the essential oils from young and adult leaves of E. benthamii presented cytotoxicity against the investigated tumor cell lines which confirms their antitumor potential. (hindawi.com)
Mammalian2
- Since consumption of large quantities of fruit and vegetables is associated with a striking reduction in the risk of developing a variety of malignancies, it is of interest that a number of edible plants contain substantial quantities of compounds that regulate mammalian enzymes of xenobiotic metabolism. (pnas.org)
- they are also useful for creating herbicide-resistant plants, and plants which contain mammalian polypeptides. (freepatentsonline.com)
Microenvironment1
- Now, as discussed in the current issue of the Journal of Clinical Investigation , Gerard Blobe, M.D., Ph.D., and a team at Duke University have explored the tumor microenvironment and identified a mechanism by which tumors evade detection. (genengnews.com)
Melanoma1
- Preliminary studies have shown that taxol may have marginal activity in acute leukemia and melanoma, and some activity has been noted in other tumors. (google.com)
Galls3
- Plant tumors or galls usually form in response to the action of a pathogen or a pest. (harvard.edu)
- [21] For example, plant galls have been characterized as tumors [22] but some authors argue that plants do not develop cancer. (wikipedia.org)
- 1982) "Regeneration of normal and fertile plants that express octopine synthase, from tobacco crown galls after deletion of tumour-controlling functions," Nature 300:752-754. (freepatentsonline.com)
Accumulation2
- Lippard and Steinmetz continue to collaborate, investigating use of this system to deliver other drugs or drug candidates, use in other types of cancers, the addition of agents on the exterior of the shell to increase accumulation inside tumors and more. (teknoscienze.com)
- The CRAG team used modified plants in which the circadian clock goes slower due to an increased and constant accumulation of TOC1, an essential component of the plant circadian clock. (cragenomica.es)
Cell cultures1
- We studied the activity of 14 compounds, all of which have been shown to interfere in plant cell division, in two animal tumor cell cultures, EL-4 and L1210. (aacrjournals.org)
Human5
- This is the first evidence that a plant-derived papillomavirus vaccine is protective in an animal model and is a proof of concept for human papillomavirus vaccines produced in plants. (asm.org)
- In this study, we used the MUC1 TR peptide as a test antigen to determine whether a plant-expressed human tumour-associated antigen can be successfully expressed in a plant system and whether it will be able to break self-antigen tolerance in a MUC1-tolerant mouse model. (mysciencework.com)
- The results indicate that a plant-derived human tumour-associated antigen is equivalent to the human antigen in the context of immune recognition. (mysciencework.com)
- Between 1995 and 2005, human consumption of land plants increased from 20-25% of total plant production on the planet each year, with both total global consumption and per capita consuming rising over that period and continuing to rise. (treehugger.com)
- If the entire human population consumed plant material like the average North American today, we would use more than 55% of all plants grown on the planet each year. (treehugger.com)
Extract4
- BERLIN: Treatment with a plant extract alleviates symptoms of Cushing Disease caused by a tumour in the brain, scientists say. (daily-sun.com)
- 1. feverfew extract has a strong anti-tumor activity. (plant-extractpowder.com)
- In this paper, we evaluated the cytotoxic potential of the extract of Bonellia albiflora , a plant utilized in the traditional Mayan medicine for treatment of chronic injuries of the mouth. (hindawi.com)
- 10 Years Experience in Plant Extract The Best Service and The Best Price to Develop Overseas Markets. (made-in-china.com)
Pathway3
- The cAMP pathway is also needed for subsequent fungal development in planta, as null mutants in any component of the pathway fail to form tumors. (apsnet.org)
- We conclude that tight regulation of the cAMP pathway is crucial for fungal development within the plant but does not interfere with the tumor induction process. (apsnet.org)
- Affirmatively, we now know that mutant p53 in humans causes an aggressive spread of a tumour by inhibiting the apoptotic pathway and cell cycle regulatory mechanisms. (europeanpharmaceuticalreview.com)
Therapeutic1
- Here, we will provide a comprehensive picture of plant RIPs and discuss successful designs and features of chimeric molecules having therapeutic potential. (mdpi.com)
Targeting1
- We report the expression of MUC1 TR peptide fused to the mucosal-targeting Escherichia coli enterotoxin B subunit (LTB-MUC1) in a plant host. (mysciencework.com)
Genomes1
- In Nature this week: CRISPR approaches to editing plant genomes, way to speed up DNA-PAINT, and more. (genomeweb.com)
Abstract1
- 1982) "Transformation in plants: potential and reality," (Abstract of Conference paper from University of Nottingham). (freepatentsonline.com)
Recombinant1
- Recombinant plant-expressed tumour-associated MUC1 peptide is. (mysciencework.com)
Arabidopsis1
- The discovery, which is published this week in the journal Developmental Cell , was made using the model plant Arabidopsis thaliana . (cragenomica.es)
Treatment8
- Plants have a long history of use in the treatment of cancer. (biomedcentral.com)
- Patients usually die from a local recurrence of the tumor, even after aggressive treatment. (medindia.net)
- However, in the case of Brucea javanica , it is one of those plants in which scientific investigations have provided enough evidence to prove that it has an impressive efficacy for the treatment of cervical, bladder and pancreatic cancers. (healthyaeon.com)
- Although their pharmacological or toxicological properties have not been thoroughly investigated, infusions and decoctions of Eucalyptus plants are widely used in the treatment of respiratory diseases, for example, common cold, influenza, and sinus congestion [ 3 , 4 ]. (hindawi.com)
- Plants that Fight Cancer, Second Edition, is a compilation that reviews cancer treatment and research-based information on the plant kingdom as the source of both known and novel chemical moieties and mixtures, many of them still under identification. (routledge.com)
- The third part of the book comprises six chapters dedicated to either plant chemotherapeutical approaches to specific cancer types (e.g. bladder, prostate) or specific groups of plant secondary metabolites with novel and promising properties for cancer treatment (e.g. naphthoquinones, lectins, phenanthridone alkaloids). (routledge.com)
- and plant lectins in cancer treatment. (routledge.com)
- These pictures clearly show that this patient, with previously treatment-resistant tumors, continues to make obvious improvement. (theweedblog.com)