Plant Tumors: A localized proliferation of plant tissue forming a swelling or outgrowth, commonly with a characteristic shape and unlike any organ of the normal plant. Plant tumors or galls usually form in response to the action of a pathogen or a pest. (Holliday, P., A Dictionary of Plant Pathology, 1989, p330)Agrobacterium tumefaciens: A species of gram-negative, aerobic bacteria isolated from soil and the stems, leafs, and roots of plants. Some biotypes are pathogenic and cause the formation of PLANT TUMORS in a wide variety of higher plants. The species is a major research tool in biotechnology.Rhizobium: A genus of gram-negative, aerobic, rod-shaped bacteria that activate PLANT ROOT NODULATION in leguminous plants. Members of this genus are nitrogen-fixing and common soil inhabitants.Plants, Genetically Modified: PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.Plant Leaves: Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)Plant Proteins: Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.Plant Roots: The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)Genes, Plant: The functional hereditary units of PLANTS.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Plant Shoots: New immature growth of a plant including stem, leaves, tips of branches, and SEEDLINGS.Plants, Medicinal: Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.DNA, Plant: Deoxyribonucleic acid that makes up the genetic material of plants.Plant Development: Processes orchestrated or driven by a plethora of genes, plant hormones, and inherent biological timing mechanisms facilitated by secondary molecules, which result in the systematic transformation of plants and plant parts, from one stage of maturity to another.Plants, Toxic: Plants or plant parts which are harmful to man or other animals.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Cell Wall: The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.Streptothricins: A group of antibiotic aminoglycosides differing only in the number of repeating residues in the peptide side chain. They are produced by Streptomyces and Actinomyces and may have broad spectrum antimicrobial and some antiviral properties.Serpins: A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.Agrobacterium: A genus of gram negative, aerobic, rod-shaped bacteria found in soil, plants, and marine mud.Neuroendocrine Tumors: Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Carcinoid Tumor: A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)Cell Line, Tumor: A cell line derived from cultured tumor cells.Neurosecretory Systems: A system of NEURONS that has the specialized function to produce and secrete HORMONES, and that constitutes, in whole or in part, an ENDOCRINE SYSTEM or organ.Crassulaceae: The stonecrop plant family of the order ROSALES, subclass Rosidae, class Magnoliopsida that grow in warm, dry regions. The leaves are thick. The flower clusters are red, yellow, or white.Teratoma: A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Research Personnel: Those individuals engaged in research.Research Support as Topic: Financial support of research activities.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Nanoparticles: Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.Plant Viruses: Viruses parasitic on plants higher than bacteria.Emperipolesis: The movement of one cell within another cell (non-phagocytic).Entosis: The processes by which one cell actively invades and becomes internalized within another cell.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Organizers, Embryonic: Cells in certain regions of an embryo that self-regulate embryonic development. These organizers have been found in dorsal and ventral poles of GASTRULA embryos, including Spemann organizer in amphibians, and Hensen node in chicken and mouse. These organizer cells communicate with each other via a network of secreted signaling proteins, such as BONE MORPHOGENETIC PROTEINS and their antagonists (chordin and noggin).Ipomoea nil: A plant species of the genus IPOMOEA, family CONVOLVULACEAE. An abundance of spontaneous mutants makes it useful in study of PLANT DNA and GENETICS.Ipomoea: A plant genus in the family CONVOLVULACEAE best known for morning glories (a common name also used with CONVOLVULUS) and sweet potato.Saussurea: A plant genus of the family ASTERACEAE, order Asterales, subclass Asteridae. It is a source of costus root oil and should not be confused with the genus COSTUS.Taraxacum: A plant genus of the family ASTERACEAE. Members contain chicoric and chlorogenic acids and germacrane- and eudesmane-type SESQUITERPENES.Darkness: The absence of light.Plantago: A plant genus of the family Plantaginaceae. The small plants usually have a dense tuft of basal leaves and long, leafless stalks bearing a terminal spike of small flowers. The seeds, known as PSYLLIUM, swell in water and are used as laxatives. The leaves have been used medicinally.Photoperiod: The time period of daily exposure that an organism receives from daylight or artificial light. It is believed that photoperiodic responses may affect the control of energy balance and thermoregulation.Abdominal NeoplasmsLymphangioleiomyomatosis: A disease characterized by the progressive invasion of SMOOTH MUSCLE CELLS into the LYMPHATIC VESSELS, and the BLOOD VESSELS. The majority of the cases occur in the LUNGS of women of child-bearing age, eventually blocking the flow of air, blood, and lymph. The common symptom is shortness of breath (DYSPNEA).Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Morus: A plant genus of the family MORACEAE that is widely planted for shade.China: A country spanning from central Asia to the Pacific Ocean.

Molecular markers and cell cycle inhibitors show the importance of cell cycle progression in nematode-induced galls and syncytia. (1/273)

Root knot and cyst nematodes induce large multinucleated cells, designated giant cells and syncytia, respectively, in plant roots. We have used molecular markers to study cell cycle progression in these specialized feeding cells. In situ hybridization with two cyclin-dependent kinases and two cyclins showed that these genes were induced very early in galls and syncytia and that the feeding cells progressed through the G2 phase. By using cell cycle blockers, DNA synthesis and progression through the G2 phase, or mitosis, were shown to be essential for gall and syncytium establishment. When mitosis was blocked, further gall development was arrested. This result demonstrates that cycles of endoreduplication or other methods of DNA amplification are insufficient to drive giant cell expansion. On the other hand, syncytium development was much less affected by a mitotic block; however, syncytium expansion was inhibited.  (+info)

Ti plasmids from Agrobacterium characterize rootstock clones that initiated a spread of crown gall disease in Mediterranean countries. (2/273)

Crown gall caused by Agrobacterium is one of the predominant diseases encountered in rose cultures. However, our current knowledge of the bacterial strains that invade rose plants and the way in which they spread is limited. Here, we describe the integrated physiological and molecular analyses of 30 Agrobacterium isolates obtained from crown gall tumors and of several reference strains. Characterization was based on the determination of the biovar, analysis of 16S ribosomal DNA restriction fragment length polymorphisms by PCR (PCR-RFLP), elucidation of the opine type, and PCR-RFLP analysis of genes involved in virulence and oncogenesis. This study led to the classification of rose isolates into seven groups with common chromosome characteristics and seven groups with common Ti plasmid characteristics. Altogether, the rose isolates formed 14 independent groups, with no specific association of plasmid- and chromosome-encoded traits. The predominant Ti plasmid characteristic was that 16 of the isolates induced the production of the uncommon opine succinamopine, while the other 14 were nopaline-producing isolates. With the exception of one, all succinamopine Ti plasmids belonged to the same plasmid group. Conversely, the nopaline Ti plasmids belonged to five groups, one of these containing seven isolates. We showed that outbreaks of disease provoked by the succinamopine-producing isolates in different countries and nurseries concurred with a common origin of specific rootstock clones. Similarly, groups of nopaline-producing isolates were associated with particular rootstock clones. These results strongly suggest that the causal agent of crown gall disease in rose plants is transmitted via rootstock material.  (+info)

Cell-division factors from Vinca rosca L. crown gall tumor tissue. (3/273)

A cell-division factor has been precipitated from extracts of cultured Vinca rosea L. crown gall tumor tissue by using the mercuric acetate procedure previously employed by Wood and colleagues to obtain their "cytokinesin I." On the basis of its mass spectrum, ultraviolet light absorbancy spectra, solubilities, chromatographic migration values, and growth activity, the factor is ribosyl-trans-zeatin, that is, 6-(4-hydroxy-3-methyl-trans-2-butenylamino)-9-beta-D-ribofuranosylpurine. Ribosylzeatin has now been isolated from tumor tissue by four experimental techniques; any possibility that it is an artifact seems to have been eliminated. Contrary to the report by Wood and colleagues, synthetic ribosylzeatin is precipitated from an aqueous solution by mercuric acetate, provided the complete precipitation procedure is utilized. These facts and others discussed strongly support our suggestion that ribosylzeatin was present in the preparation ("cytokinesin I") examined by Wood and colleagues in several biological assays. The reasons advanced by Wood and others for rejecting this suggestion have been found either not to be pertinent to the question or to have insufficient experimental bases.  (+info)

An inherited "neoplasm" in fungus. (4/273)

An abnormal growth form in the fungus Schizophyllum commune is described that interferes with the development of reproductive structures. The abnormality, which takes the form of relatively large, compact, hemispherical bodies, depends on a dominant Mendelian gene, mound, for its expression. When mound is expressed in a mycelium that has the potential to form fruiting bodies, the fruiting response is affected and the effect is variable within a replicate series: fruiting bodies may be normal or abnormal, abort at various stages, or not develop at all. Occasionally, fruit bodies are overgrown and are completely enveloped by the hemispherical bodies. When hyphae from hemispherical bodies are subcultured, a seemingly normal mycelium forms that eventually differentiates hemispherical structures, but the ability to form fruiting bodies in not expressed. Continuous mycelial subculture has shown this loss of fruiting expression to be a permanent transformation, which is demonstrated to be a characteristic of hemispherical bodies.  (+info)

Suppression of the neoplastic state with the acquisition of specialized functions in cells, tissues, and organs of crown gall teratomas of tobacco. (5/273)

The neoplastic state in cells of tissues and organs that develop from cloned lines of crown gall teratomas of tobacco may be completely but reversibly suppressed. Stems and leaves found on teratoma shoots may appear morphologically normal and such organs contain all of the specialized cell types and are histologically and functionally indistinguishable from those found in normal tobacco shoots of comparable age. When however, specialized cells of several different kinds that are present in stems and leaves of the teratomas are excised from the plant and grown on a basic culture medium they again assume their neoplastic properties. The results of this study indicate that the morphogenetic factors and mechanisms that govern so precisely growth, cellular differentiation, and organogenesis during the normal course of development can completely suppress the tumorous state, leading to the formation of cells, tissues, and organs that appear normal in every respect but are, in fact, inherently neoplastic. Whether the normal or tumor phenotype is expressed appears to depend on the activation or repression of select biosynthetic systems, one of which, the auxin sytems, has been identified here.  (+info)

High relatedness and inbreeding at the origin of eusociality in gall-inducing thrips. (6/273)

Within the haplodiploid eusocial gall-inducing thrips, a species-level phylogeny combined with genetic data for five eusocial species enables an inference of levels of relatedness and inbreeding values for lineages at the origin of eusociality. Character optimization using data from five eusocial species indicates that the lineage or lineages where eusociality is inferred to have originated exhibit relatedness of 0.64-0.92, and F(IS) of 0.33-0.64. The high inbreeding coefficients found in these eusocial thrips have increased relatedness among and within both sexes and have reduced the haplodiploidy-induced relatedness asymmetries [Hamilton, W. D. (1964) J. Theor. Biol. 7, 1-52]. These results indicate that unusually high relatedness is associated with the origin of eusociality, and they suggest a role for inbreeding in the evolution of bisexual helping.  (+info)

Bruchins: insect-derived plant regulators that stimulate neoplasm formation. (7/273)

Pea weevil (Bruchus pisorum L.) oviposition on pods of specific genetic lines of pea (Pisum sativum L.) stimulates cell division at the sites of egg attachment. As a result, tumor-like growths of undifferentiated cells (neoplasms) develop beneath the egg. These neoplasms impede larval entry into the pod. This unique form of induced resistance is conditioned by the Np allele and mediated by a recently discovered class of natural products that we have identified from both cowpea weevil (Callosobruchus maculatus F.) and pea weevil. These compounds, which we refer to as "bruchins," are long-chain alpha,omega-diols, esterified at one or both oxygens with 3-hydroxypropanoic acid. Bruchins are potent plant regulators, with application of as little as 1 fmol (0.5 pg) causing neoplastic growth on pods of all of the pea lines tested. The bruchins are, to our knowledge, the first natural products discovered with the ability to induce neoplasm formation when applied to intact plants.  (+info)

Leifsonia poae gen. nov., sp. nov., isolated from nematode galls on Poa annua, and reclassification of 'Corynebacterium aquaticum' Leifson 1962 as Leifsonia aquatica (ex Leifson 1962) gen. nov., nom. rev., comb. nov. and Clavibacter xyli Davis et al. 1984 with two subspecies as Leifsonia xyli (Davis et al. 1984) gen. nov., comb. nov. (8/273)

The new genus Leifsonia gen. nov. with two new species, Leifsonia poae sp. nov. (type strain VKM Ac-1401T) and Leifsonia aquatica (ex Leifson 1962) nom. rev., comb. nov. (the type species, with VKM Ac-1400T = DSM 20146T = JCM 1368T as type strain), is proposed to accommodate bacteria found in Poa annua root gall, induced by the nematode Subanguina radicicola, and 'Corynebacterium aquaticum' Leifson 1962. Further, it is proposed to reclassify Clavibacter xyli Davis et al. 1984 with two subspecies in the new genus as Leifsonia xyli (Davis et al. 1984) comb. nov., Leifsonia xyli subsp. xyli (Davis et al. 1984) comb. nov. and Leifsonia xyli subsp. cynodontis (Davis et al. 1984) comb. nov. Members of the proposed genus are characterized by coryneform morphology, peptidoglycans based upon 2,4-diaminobutyric acid, the major menaquinone MK-11, phosphatidylglycerol and diphosphatidylglycerol as principal phospholipids, the high content of anteiso- and iso-branched saturated fatty acids, and a DNA G+C base composition of 66-73 mol%. They form a distinct phylogenetic branch attached to the line of descent of Agromyces spp. The new and reclassified species of the new genus clearly differ from each other phylogenetically and phenetically and can be recognized by their morphologies, the cell wall sugar composition, the requirement of complex media for growth, and numerous physiological characteristics, including the oxidase reaction.  (+info)

  • The transcription of the pTiAg57 virF is inducible by the plant phenolic compound acetosyringone through the presence of a vir-box consensus sequence in its promoter region. (ox.ac.uk)
  • The presence of a virF locus on the octopine Ti plasmid makes N. glauca a host plant for these strains, indicating that the VirF protein is a host-range determinant. (ox.ac.uk)
  • The VirF protein from pTiAg57 can complement octopine A. tumefaciens strains deleted for virF as shown by tumor formation on N. glauca. (ox.ac.uk)
  • We first generated shoot-forming and unorganized calli in tobacco plants upon introduction of auxin and cytokinin biosynthesis genes, and 6b gene which modulates the effects of these plant growth substances. (nii.ac.jp)
  • Finally, the psaB and ribonucleoprotein gene seem to be required for chloroplast development, and further investigation is necessary to determine the relationship between plastid and total plant development. (nii.ac.jp)
  • We assumed that in these tissues, the genes involved in plant differentiation could be induced or repressed, and thus current project is directed to isolation and characterization of such genes. (nii.ac.jp)
  • Ricin, the plant RIP prototype that comprises a catalytic A subunit linked to a galactose-binding lectin B subunit to allow cell surface binding and toxin entry in most mammalian cells, shows a potency in the picomolar range. (mdpi.com)
  • The most promising way to exploit plant RIPs as weapons against cancer cells is either by designing molecules in which the toxic domains are linked to selective tumor targeting domains or directly delivered as suicide genes for cancer gene therapy. (mdpi.com)
  • After silibinin treatment, tumour cells resumed normal ACTH production, tumour growth slowed down and symptoms of Cushing Disease disappeared in mice. (daily-sun.com)
  • These results indicate that some inhibitors of plant cell division are capable of inhibiting the proliferation of animal tumor cells. (aacrjournals.org)
  • Neuroendocrine tumors (NETs) represent rare tumors that are derived from cells of the embryonic neural crest. (spandidos-publications.com)
  • MTCs are calcitonin producing tumors arising from the parafollicular C-cells and occur in ~4-10% of all thyroid tumors ( 2 ). (spandidos-publications.com)
  • In a previous study, pheophorbid-a, a chlorophyll derivative in Christia vespertilionis plant extracts showed high antiproliferative activity in MTC cells ( 13 ). (spandidos-publications.com)
  • Tumour suppression gene products are produced by cells to monitor the efficiency of the cell cycle by populating specific phases in the process of both DNA and cell replications 1 . (europeanpharmaceuticalreview.com)
  • Although it is well known that Tyr phosphatases play a critical role in signal transduction in animal cells, little is understood of the functional significance of Tyr phosphatases in higher plants. (plantcell.org)
  • Although both Ser/Thr and Tyr phosphorylation play a crucial role in cellular regulation in animal systems, only Ser/Thr phosphorylation has been established as an important regulatory mechanism in plant cells. (plantcell.org)
  • The normal immunity system can identify and kill tumor cells, however, the occurrence rate of tumor will enhance if it lacks of the ability of immunologic defence or immunological recognition. (cnki.com.cn)
  • The elongated shape of the nanoparticle causes it to tumble along the margins of blood vessels, remain unnoticed by immune cells and pass through the leaky vasculature of tumors and accumulate inside. (teknoscienze.com)
  • Inside tumors, the nanoparticles gather inside the lysosomal compartments of cancer cells, where they are, in essence, digested. (teknoscienze.com)
  • In vivo anti-tumor activity was evaluated in nude mice bearing subcutaneously human Ando-2 melanoma cells. (biomedcentral.com)
  • The intraperitoneal injection or oral administration of LACE extract in nude mice inhibits in vivo tumor growth of Ando-2 melanoma cells and prolongs the survival day of the mice. (biomedcentral.com)
  • The LACE extract presented in vivo anti-tumoral activity in nude mice against tumor growth of Ando-2 melanoma cells. (biomedcentral.com)
  • Although anti-PD-1 antibodies initially bound to T cells as intended, the authors found that tumor-associated macrophages quickly removed these antibodies from T cells, thus inactivating them. (sciencemag.org)
  • Sulforaphane induces several phase 2 enzymes in both cultured cells and mouse tissues ( 15 ), blocks 7,12-dimethylbenz( a )anthracene (DMBA)-initiated mammary tumor formation in rats ( 16 ), and inhibits neoplastic nodule formation in cultured mouse mammary glands ( 17 ). (pnas.org)
  • Myrosinase (see ref. 18 ) is normally segregated from glucosinolates and is released when plant cells are injured. (pnas.org)
  • When we counted the number of cells in the leaves of the plants that overexpress TOC1, we saw that there were fewer cells, which suggested that by modifying the circadian clock, we were also modifying the cell division pace ", explains Jorge Fung, pre-doctoral student and first author of the work. (cragenomica.es)
  • The cells of the plants that overexpress TOC1 remain longer at the G1 phase, failing to enter the S phase at the appropriate time " says Jorge Fung. (cragenomica.es)
  • The composition of tumor-infiltrating immune cells has been identified as a key factor influencing CPI therapy success. (sciencemag.org)
  • A lack of the chemokine CCL4 within the tumor microenvironment leads to the absence of CD103 + dendritic cells (DCs), a crucial cell population influencing CPI responsiveness. (sciencemag.org)
  • Intravenous CBD-CCL4 administration recruits CD103 + DCs and CD8 + T cells and improves the antitumor effect of CPI immunotherapy in multiple tumor models, including poor responders to CPI. (sciencemag.org)
  • The scientists say their study also supports the use of TGF-β inhibitors to enhance the efficacy of therapies that promote immune-mediated elimination of tumor cells. (genengnews.com)
  • Work with the murine models demonstrated that the loss of tumor-expressed TGFBR3/sTGFBR3 enhanced TGF-β signaling within locoregional dendritic cells (DC). (genengnews.com)
  • NEW YORK (GenomeWeb News) - Researchers from the US and Canada reported online in Nature yesterday that they have successfully used single-cell sequencing to discern copy number patterns in individual cells from primary and metastatic breast tumors. (genomeweb.com)
  • SAN FRANCISCO (GenomeWeb) - Tumor sequencing tests may pick up not only somatic mutations found in the tumor but also a certain class of non-cancerous mutations that accumulate in hematopoietic stem cells and are associated with age, according to a recent study published by researchers from Rutgers University and Foundation Medicine. (genomeweb.com)
  • Brucea javanica (Brucea javanica (L.) Merr) is one of those plants that needs far more recognition in this catergory for its incredible ability to selectively kill cancer cells. (healthyaeon.com)
  • Down-regulation of TCTP can induce tumor reversion, and in combination with some drugs that decrease the level of TCTP and will lead to kill tumor cells. (wikipedia.org)
  • TCTP knockdown in primary mammary tumor cells, results in increased p53 expression and a decreased number of stem-like cancer cells. (wikipedia.org)
  • Hsp70 is abundantly expressed in malignant human tumors of various origins, whereas in normal cells, its expression is mainly stress inducible. (pnas.org)
  • Ursolic acid demonstrated a significant inhibition of the proliferation of cultured tumour cells. (essense-of-life.com)
  • The treatment of cancer with chemotherapeutic agents and radiation has two major problems: tumor resistance to therapy and toxicity toward normal cells. (essense-of-life.com)
  • Recent research has suggested that plant polyphenols (which includes ursolic acid) might be used to sensitize tumor cells to chemotherapeutic agents and radiation therapy by inhibiting pathways that lead to treatment resistance. (essense-of-life.com)
  • PhysOrg.com) -- It has long been known that heat is an effective weapon against tumor cells. (phys.org)
  • During a single exposure to a near-infrared laser, the nanorods heat up to 70 degree Celsius, hot enough to kill tumor cells. (phys.org)
  • Additionally, heating them to a lower temperature weakens tumor cells enough to enhance the effectiveness of existing chemotherapy treatments, raising the possibility of using the nanorods as a supplement to those treatments. (phys.org)
  • The nanorods could also be used to kill tumor cells left behind after surgery. (phys.org)
  • This invention relates to chimeric genes which are capable of being expressed in plant cells. (freepatentsonline.com)
  • 1977) "T-DNA from Agrobacterium Ti plasmid is in the nuclear DNA fraction of crown gall tumor cells," Proc. (freepatentsonline.com)
  • 1982) "Agrobacterium rhizogenes inserts T-DNA into the genomes of the host plant root cells," Nature 295:432-434. (freepatentsonline.com)
  • The reproductive success of seed plants is performed and based on the invention of the pollen tube, an extension of the pollen grain that is produced under favorable conditions and that allows the sperm cells to move from the male gametophyte towards the female one. (mdpi.com)
  • From a pure biological point of view, the pollen tube is an atypical plant cell, because it grows by a tip-growing mechanism, rather than by the typical diffuse way of somatic cells. (mdpi.com)
  • Chemical specificity of effector cell/tumor cell bridging by a Viscum album rhamnogalacturonan enhancing cytotoxicity of human NK cells. (biomedsearch.com)
  • The component in Viscum album extract Iscador-M enhancing the NK cytotoxicity of human CD56+CD3- NK cells (87-95% enrichment) in cocultures with K562 tumor cells and increasing the formation of NK cell/tumor cell conjugates was identified as a rhamnogalacturonan. (biomedsearch.com)
  • The rapid formation of NK cell/tumor cell conjugates in the presence of V. album extract was based on the bridging of NK cells with tumor cells by rhamnogalacturonan. (biomedsearch.com)
  • She has acquired years of experience in the laboratory evaluating the immune cells present in individual brain tumors in an effort to understand how we can use the immune response to kill tumor cells. (choc.org)
  • With experiments on these plants we now have a better understanding of how cancer cells react in the human body,' says the principle investigator, Maikel Peppelenbosch. (prnewswire.com)
  • By imitating this process in plants and studying what happens to the plant cells we have learned a great deal about the development of Peutz-Jeghers Syndrome. (prnewswire.com)
  • Turkson, along with collaborators Leng Chee Chang, Dianqing Sun and Supakit Wongwiwatthananukit at the University of Hawai'i at Hilo Daniel K. Inouye College of Pharmacy, published a study a year and half ago showing that the natural compounds from the ironweed plant were effective in killing breast cancer and brain tumor cells and blocked the development and growth of these cancers in the laboratory. (hawaii.edu)
  • Xingyun Qi , Roman Pleskot , Niloufer G. Irani and Daniël Van Damme look back at the stimulating and lively discussions on the mechanism and functions of endocytosis in plant cells, with an aim to bridge the gap in knowledge about the endocytic machinery and its cargos in the plant field. (biologists.org)
  • RNA gel blot analysis and examination of promoter-reporter constructs in transgenic Arabidopsis plants revealed that the AtPTEN1 gene is expressed exclusively in pollen grains during the late stage of development. (plantcell.org)
  • We first generated shoot-forming and unorganized calli in tobacco plants upon introduction of auxin and cytokinin biosynthesis genes, and 6b gene which modulates the effects of these plant growth substances. (nii.ac.jp)
  • Finally, the psaB and ribonucleoprotein gene seem to be required for chloroplast development, and further investigation is necessary to determine the relationship between plastid and total plant development. (nii.ac.jp)
  • Analysis of his tumors following surgeries, biopsies and autopsy revealed several genetic aberrations, including multiple copies of a region on chromosome 4q, which includes the KIT gene. (medindia.net)
  • Additional findings included the loss of the gene PKP4, which is associated with increased tumor size. (medindia.net)
  • Join this webinar to learn how spatial resolution of gene expression in tumor tissue reveals new insights in biomarker discovery and therapeutic response. (genomeweb.com)
  • A new study has shown that survival rates among patients with glioma double if the tumor carries a methylated MGMT gene. (news-medical.net)
  • Moreover, in lower plants it is phytochrome that steers growth direction - that simply can't be done via gene regulation. (innovations-report.com)
  • Bayer's new Vitrakvi for tumors with NTRK gene fusions is meeting skepticism in England and Germany, where cost watchdogs on Friday rejected it. (fiercepharma.com)
  • 1983), "A chimaeric antibiotic resistance gene as a selectable marker for plant cell transformation," Nature 304:184-187. (freepatentsonline.com)
  • 1983) "Multiple Viral Specific Transcripts from the Genome of Cauliflower Mosaic Virus," Proceedings of the Miami Winter Symposium, Jan. 1983, published in Advances in Gene Technology: Molecular Genetics of Plants and Animals (Ahmad et al. (freepatentsonline.com)
  • 1983) "Ti and Ri Plasmids as Vectors for Genetic Engineering of Higher Plants," Proceedings of the Miami Winter Symposium, Jan. 1983, published in Advances in Gene Technology: Molecular Genetics of Plants and Animals (Ahmad et al. (freepatentsonline.com)
  • NEWS, 26 March Gene therapy on a tomato gene could be of value in future treatment of brain tumors, according to a new study from Karolinska Institutet and Lund University. (ki.se)
  • A massive abdominal tumor measuring about 10 kg has been removed from a female patient, by surgeons in the western Croatian town of Gospic. (medindia.net)
  • Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice. (nih.gov)
  • Here, we present a detailed analysis of PVX biodistribution and clearance in healthy mice and mouse tumor xenograft models using a combination of ex vivo whole-organ imaging, quantitative fluorescence assays and immunofluorescence microscopy. (nih.gov)
  • Triple-negative breast cancer tumors of mice treated with the phenanthriplatin -carrying nanoparticles were four times smaller than those treated either with cisplatin, a common and related chemotherapy drug, or free phenanthriplatin injected intravenously into circulation. (teknoscienze.com)
  • Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice. (mysciencework.com)
  • Scientists from Case Western Reserve University School of Medicine as teams with analysts from Dartmouth Geisel School of Medicine and RWTH Aachen University (Germany) have adjusted infection particles - that regularly taint potatoes - to fill in as tumor tranquilize conveyance gadgets for mice. (health11.com)
  • What's more, at the same time infusing the nanoscale plant infection particles and chemotherapy sedate - doxorubicin - into tumor destinations additionally helps stop tumor movement in mice. (health11.com)
  • The results are the first to indicate "inoculating" mice with potato infection nanoparticles at a growth site can create a hostile to tumor reaction. (health11.com)
  • When transplanted into mice, tumor genomes evolve differently than they do in patients, study finds. (the-scientist.com)
  • Human tumors transplanted into laboratory mice disappeared or shrank when scientists treated the animals with a single antibody, according to a new study from the Stanford University School of Medicine. (medicalxpress.com)
  • In a study reported in the team's Cancer Research paper, tumors in mice that received an intravenous injection of nanorods plus near-infrared laser treatment disappeared within 15 days. (phys.org)
  • C57BL/6 mice immunized with E7-containing crude foliar extracts developed both humoral and cell-mediated immune responses and were protected from tumor development after challenge with the E7-expressing C3 tumoral cell line. (elsevier.com)
  • We show that, in contrast to animal TCTP, plant AtTCTP is not implicated in regulating postmitotic growth. (nih.gov)
  • Our data provide evidence that TCTP function in regulating cell division is part of a conserved growth regulatory pathway shared between plants and animals. (nih.gov)
  • A ) Siliques produced by WT or by heterozygous AtTCTP/tctp -1 and AtTCTP/tctp -2 plants. (nih.gov)
  • B ) Semiquantitative RT-PCR analysis showing no expression of AtTCTP in leaves of both tctp -1 and tctp -2 plants. (nih.gov)
  • C ) Western blot analysis of AtTCTP accumulation in leaves of WT, tctp -1, and tctp -2 plants using anti-AtTCTP antibody. (nih.gov)
  • Nanoparticles based on plant viruses are emerging biomaterials for medical applications such as drug delivery and imaging. (nih.gov)
  • The long, thin tobacco mosaic virus nanoparticles are naturals for delivering the drug candidate into tumors, said Steinmetz, who was appointed by the Case Western Reserve School of Medicine. (teknoscienze.com)
  • CV extracts showed antiprolife-rative and proapoptotic effects in all MTC and SI-NET cell lines, whereby high growth inhibition was observed by treatment with the ethylacetate-extracts (CV-45) in tumor cell lines but not in normal human fibroblasts. (spandidos-publications.com)
  • Cell walls from normal and tumor tissues in culture also show this difference, indicating that the two types of tissue stably maintain this difference under these conditions. (sciencemag.org)
  • Crown-gall tumors thus resemble embryonic tissues in this respect. (sciencemag.org)
  • OsTCTP was ubiquitously expressed in all examined plant tissues, especially in actively dividing and differentiating tissues, such as roots and nodes. (biomedcentral.com)
  • However, it's difficult to heat patients' tumors without damaging nearby tissues. (phys.org)
  • Another advantage of the nanorods is that by coating them with different types of light-scattering molecules, they can be designed to simultaneously gather multiple types of information - not only whether there is a tumor, but whether it is at risk of invading other tissues, whether it's a primary or secondary tumor, or where it originated. (phys.org)
  • Scientists around Gunter Stalla, endocrinologist at the Max Planck Institute of Psychiatry in Munich, have discovered in cell cultures, animal models and human tumour tissue that a harmless plant extract can be applied to treat Cushing Disease. (daily-sun.com)
  • As there are too many HSP90 molecules in the tumour tissue, they stick to the glucocorticoid receptor," said Paez-Pereda. (daily-sun.com)
  • Habituated tissue cultures, which resemble crown-gall tumor cultures, however, form cell walls that are inhibitory like those of the normal cultures from which they are derived. (sciencemag.org)
  • Neuroendocrine tumors respond poorly to radiation and conventional chemotherapy, hence surgical removal of the neoplastic tissue is still the most effective way of treatment. (spandidos-publications.com)
  • A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. (innovations-report.com)
  • Most of those patients are treated with chemotherapy and/or radiation, which are often effective but can have debilitating side effects because it's difficult to target tumor tissue. (phys.org)
  • Any tissue that lights up, other than the liver or spleen, could harbor an invasive tumor. (phys.org)
  • The analysts found infusing potato infection particles into melanoma tumor locales actuates a hostile to tumor invulnerable framework reaction. (health11.com)
  • At the point when the plant-based infection particles and the medications could take a shot at their own, we saw the best benefit. (health11.com)
  • Steinmetz and her group will next research instruments behind the potato infection particles' hostile to tumor impacts. (health11.com)
  • Now, MIT researchers have developed tiny gold particles that can home in on tumors, and then, by absorbing energy from near-infrared light and emitting it as heat, destroy tumors with minimal side effects. (phys.org)
  • This class of particles provides the most efficient method of specifically depositing energy in tumors," he said. (phys.org)
  • In designing the particles, the researchers took advantage of the fact that blood vessels located near tumors have tiny pores just large enough for the nanorods to enter. (phys.org)
  • A phlorogrucinol-monoterpene derivative, euglobal-G1, obtained from leaves of E. grandis exhibited a remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[ α ]anthracene [ 6 ]. (hindawi.com)
  • As the incidence of skin tumors has been steadily growing, there is an urgent need for the preventive measures as well as the improved therapeutic approaches. (elsevier.com)
  • The major aim of this critical review is to provide recent updates on the molecular and cellular targets for the prevention and therapy of skin tumors with a special focus on the crossroad between inflammation and carcinogenesis as the most promising approach to chemoprevention. (elsevier.com)
  • The feasibility of PPs to prevent/ cure specific cutaneous toxicity connected to anti-EGFR therapy and to reduce multidrug resistance of skin tumors is also discussed. (elsevier.com)
  • Dr. Plant is a member of the neuro-oncology team at CHOC and cares for all types of childhood brain tumors. (choc.org)
  • Clinical targeted exome-based sequencing in combination with genome wide copy number profiling: A CLIA certified approach for precision medicine in 203 pediatric brain tumors. (choc.org)
  • Testicular germ cell cancer, a disease that is rare but growing in incidence in men in the United States, is considered to be among the most curable of solid tumors. (news-medical.net)
  • Scientists at the Genome Institute of Singapore (GIS) have unraveled the mechanism that causes liver cancer (hepatocellular carcinoma, HCC), one of the most common solid tumors worldwide. (medicalxpress.com)
  • It has been recognized all over the world and plant polysaccharides have anti-tumor effect through their immunomodulating effect on the organisms which carried tumor. (cnki.com.cn)
  • In a pair of firsts, researchers at Case Western Reserve University and Massachusetts Institute of Technology have shown that the drug candidate phenanthriplatin can be more effective than an approved drug in vivo, and that a plant-virus-based carrier successfully delivers a drug in vivo. (teknoscienze.com)
  • The researchers say delivery of the phenanthriplatin into the tumor led to its improved performance over cisplatin or free phenanthriplatin. (teknoscienze.com)
  • Researchers at Translational Genomics Research Institute (TGen) and Scottsdale Healthcare said that studying how tumors evolve can help the development of new treatments which can prevent the cancer from recurring. (medindia.net)
  • TGen researchers tracked several years of tumor evolution in a 47-year-old male patient with maxillary sinus carcinoma (MSC), a rare cancer of the sinus cavities beneath the cheeks that often requires surgical removal that is disfiguring. (medindia.net)
  • To reveal how the circadian clock controls the cell cycle, the researchers analysed the duration of each cell cycle phase in the leaves of plants that overexpress TOC1 and compared it with control plants. (cragenomica.es)
  • This increase stems from higher plant colonization rates and lower extinction rates in connected versus unconnected fragments, researchers report in the Sept. 27 Science . (sciencenews.org)
  • Every tumor is different, which is why Bayer researchers are working on new, personalized forms of treatment which will use small molecules to target the causes of cancer. (wczasy-egipt.com)
  • The patient in the study received conventional treatment, which included surgical removal of his tumors, radiation therapy and chemotherapy, and participation in a clinical trial. (medindia.net)
  • With chemotherapy treatment, 99 percent of drugs administered typically don't reach the tumor, said von Maltzahn. (phys.org)
  • The Gynecologic Oncology Group (GOG) is currently conducting a randomized phase II trial (Clinical trial ID: NCT104522) comparing BEP with carboplatin and paclitaxel for patients with advanced or recurrent chemotherapy-naive sex cord stromal tumors. (medscape.com)
  • The second part is a brief journey in pharmacognosy, with detailed information about each of the fourteen different chemical groups of plant secondary metabolites, their use in cancer chemotherapy, and updated information on the biotechnological production of the most representative compounds in clinical practice. (routledge.com)
  • Since the compounds are found in the plant, they are less toxic than traditional forms of treatment such as chemotherapy. (hawaii.edu)
  • The data support a role of plant AtTCTP as a positive regulator of mitotic growth by specifically controlling the duration of the cell cycle. (nih.gov)
  • The study also suggests that, although the cell division machinery is shared in all multicellular organisms to control growth, cell expansion can be uncoupled from cell division in plants but not in animals. (nih.gov)
  • Now, a research team from the Centre for Research in Agricultural Genomics (CRAG), led by the CSIC researcher Paloma Mas, has shown, for the first time in plants, that the circadian clock controls the speed of the cell cycle and, consequently, regulates the cell division and growth in synchronization with the day and night cycles. (cragenomica.es)
  • Mercury (Hg) is not only a threat to public health but also a growth risk factor to plants, as it is readily accumulated by higher plants. (biomedcentral.com)
  • Generally, plants adjust their growth to fit in with their local environment, light being easily the most important factor - after all, they need light to live. (innovations-report.com)
  • Whereas phototropin somehow steers growth direction in higher plants, phytochrome controls most aspects of plant development including germination, stem extension, greening and even flowering. (innovations-report.com)
  • Though population growth and rising demand for resources as more of the world enters into consumeristic lifestyles both play a part in the rising amount of plant life consumed, as this chart shows, on a global basis rising per capita increases in consumption have far outpaced the influence of population growth. (treehugger.com)
  • Topical application of ursolic acid inhibited TPA-induced initiation and promotion of tumor growth. (essense-of-life.com)
  • This study suggests for the first time the ability of S. perfoliata, S. thymbra, S. officinalis, L. nobilis and P. palestina essential oils and some identified terpenes to inhibit human tumor cell growth. (nih.gov)
  • A gardener explains that growing lavender plants requires planting them in good compost or potting soil, putting them in a place with full, hot sun and trimming them back in the fall for a lush growth the following spring. (nottingham.ac.uk)
  • In the following paragraphs we explore how the specific phytochemicals from medicinal plants can be used in either preventing the formation of mutant p53, or shutting down the activities of mutant p53 in the metastasis of malignancies. (europeanpharmaceuticalreview.com)
  • Beyond limited empirical observations, not all medicinal plants have established scientific studies to support their effectiveness. (healthyaeon.com)
  • The effectiveness of medicinal plants and foods to treat cancer is perhaps receiving the most widespread attention. (healthyaeon.com)
  • The results demonstrate the cytotoxic potential of the B. albiflora hexanic fraction and substantiate the importance of the study of the traditional Mayan medicinal plants. (hindawi.com)
  • Together with what was previously described, the traditional medicine of the indigenous pueblos was recognized by the World Health Organization (WHO), which caused a powerful drive toward the research of medicinal plants [ 1 ]. (hindawi.com)
  • Bolivia-Kallawayan medicinal plants as leads to anti-HIV, anti-tumor and other potential drugs / by Qi Jia. (tcu.edu)
  • In the last two decades, natural plant derived polyphenols (PPs, resveratrol, silibinin, green tea polyphenols, flavonoids, anthocyanins, etc.) have been drawing particular interest as emerging active substances in dermatological/ cosmeceutical compositions for the prevention, slowing, or reversion of skin tumorigenesis (chemoprevention). (elsevier.com)
  • Lu Y, Li L, Zhang JW, Zhong XQ, Wei JA, Han L. Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-α-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-κB-myosin light chain kinase-myosin light chain pathway. (wjgnet.com)
  • Preliminary studies have shown that taxol may have marginal activity in acute leukemia and melanoma, and some activity has been noted in other tumors. (google.com)
  • The condition was clinically diagnosed as a right-sided benign tumor of the vastus lateralis muscle. (who.int)
  • The Occlusin 500 Artificial Embolization Device (OCL 500) is a microspherical embolization agent approved for the treatment of highly vascularized, unresectable tumors, e.g., hepatocellular carcinoma or renal cell carcinoma. (medgadget.com)
  • Now, as discussed in the current issue of the Journal of Clinical Investigation , Gerard Blobe, M.D., Ph.D., and a team at Duke University have explored the tumor microenvironment and identified a mechanism by which tumors evade detection. (genengnews.com)
  • Lippard and Steinmetz continue to collaborate, investigating use of this system to deliver other drugs or drug candidates, use in other types of cancers, the addition of agents on the exterior of the shell to increase accumulation inside tumors and more. (teknoscienze.com)
  • The CRAG team used modified plants in which the circadian clock goes slower due to an increased and constant accumulation of TOC1, an essential component of the plant circadian clock. (cragenomica.es)
  • In general, the essential oils from young and adult leaves of E. benthamii presented cytotoxicity against the investigated tumor cell lines which confirms their antitumor potential. (hindawi.com)
  • We report the expression of MUC1 TR peptide fused to the mucosal-targeting Escherichia coli enterotoxin B subunit (LTB-MUC1) in a plant host. (mysciencework.com)
  • 1982) "Transformation in plants: potential and reality," (Abstract of Conference paper from University of Nottingham). (freepatentsonline.com)
  • Plants have a long history of use in the treatment of cancer. (biomedcentral.com)
  • Patients usually die from a local recurrence of the tumor, even after aggressive treatment. (medindia.net)
  • However, in the case of Brucea javanica , it is one of those plants in which scientific investigations have provided enough evidence to prove that it has an impressive efficacy for the treatment of cervical, bladder and pancreatic cancers. (healthyaeon.com)
  • Although their pharmacological or toxicological properties have not been thoroughly investigated, infusions and decoctions of Eucalyptus plants are widely used in the treatment of respiratory diseases, for example, common cold, influenza, and sinus congestion [ 3 , 4 ]. (hindawi.com)
  • Plants that Fight Cancer, Second Edition, is a compilation that reviews cancer treatment and research-based information on the plant kingdom as the source of both known and novel chemical moieties and mixtures, many of them still under identification. (routledge.com)
  • The third part of the book comprises six chapters dedicated to either plant chemotherapeutical approaches to specific cancer types (e.g. bladder, prostate) or specific groups of plant secondary metabolites with novel and promising properties for cancer treatment (e.g. naphthoquinones, lectins, phenanthridone alkaloids). (routledge.com)
  • and plant lectins in cancer treatment. (routledge.com)
  • These pictures clearly show that this patient, with previously treatment-resistant tumors, continues to make obvious improvement. (theweedblog.com)