A localized proliferation of plant tissue forming a swelling or outgrowth, commonly with a characteristic shape and unlike any organ of the normal plant. Plant tumors or galls usually form in response to the action of a pathogen or a pest. (Holliday, P., A Dictionary of Plant Pathology, 1989, p330)
A species of gram-negative, aerobic bacteria isolated from soil and the stems, leafs, and roots of plants. Some biotypes are pathogenic and cause the formation of PLANT TUMORS in a wide variety of higher plants. The species is a major research tool in biotechnology.
A genus of gram-negative, aerobic, rod-shaped bacteria that activate PLANT ROOT NODULATION in leguminous plants. Members of this genus are nitrogen-fixing and common soil inhabitants.
PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.
The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)
The functional hereditary units of PLANTS.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
New immature growth of a plant including stem, leaves, tips of branches, and SEEDLINGS.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
Deoxyribonucleic acid that makes up the genetic material of plants.
Processes orchestrated or driven by a plethora of genes, plant hormones, and inherent biological timing mechanisms facilitated by secondary molecules, which result in the systematic transformation of plants and plant parts, from one stage of maturity to another.
Plants or plant parts which are harmful to man or other animals.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.
A group of antibiotic aminoglycosides differing only in the number of repeating residues in the peptide side chain. They are produced by Streptomyces and Actinomyces and may have broad spectrum antimicrobial and some antiviral properties.
A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.
A genus of gram negative, aerobic, rod-shaped bacteria found in soil, plants, and marine mud.
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
A cell line derived from cultured tumor cells.
A system of NEURONS that has the specialized function to produce and secrete HORMONES, and that constitutes, in whole or in part, an ENDOCRINE SYSTEM or organ.
The stonecrop plant family of the order ROSALES, subclass Rosidae, class Magnoliopsida that grow in warm, dry regions. The leaves are thick. The flower clusters are red, yellow, or white.
A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Those individuals engaged in research.
Financial support of research activities.
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
Viruses parasitic on plants higher than bacteria.
The movement of one cell within another cell (non-phagocytic).
The processes by which one cell actively invades and becomes internalized within another cell.
Elements of limited time intervals, contributing to particular results or situations.
Cells in certain regions of an embryo that self-regulate embryonic development. These organizers have been found in dorsal and ventral poles of GASTRULA embryos, including Spemann organizer in amphibians, and Hensen node in chicken and mouse. These organizer cells communicate with each other via a network of secreted signaling proteins, such as BONE MORPHOGENETIC PROTEINS and their antagonists (chordin and noggin).
A plant species of the genus IPOMOEA, family CONVOLVULACEAE. An abundance of spontaneous mutants makes it useful in study of PLANT DNA and GENETICS.
A plant genus in the family CONVOLVULACEAE best known for morning glories (a common name also used with CONVOLVULUS) and sweet potato.
A plant genus of the family ASTERACEAE, order Asterales, subclass Asteridae. It is a source of costus root oil and should not be confused with the genus COSTUS.
A plant genus of the family ASTERACEAE. Members contain chicoric and chlorogenic acids and germacrane- and eudesmane-type SESQUITERPENES.
The absence of light.
A plant genus of the family Plantaginaceae. The small plants usually have a dense tuft of basal leaves and long, leafless stalks bearing a terminal spike of small flowers. The seeds, known as PSYLLIUM, swell in water and are used as laxatives. The leaves have been used medicinally.
The time period of daily exposure that an organism receives from daylight or artificial light. It is believed that photoperiodic responses may affect the control of energy balance and thermoregulation.
Hydrazine substituted by one methyl group.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Tumors or cancer of the human BREAST.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Tumors or cancer of the LUNG.
A plant genus of the family MORACEAE that is widely planted for shade.
A country spanning from central Asia to the Pacific Ocean.

Molecular markers and cell cycle inhibitors show the importance of cell cycle progression in nematode-induced galls and syncytia. (1/273)

Root knot and cyst nematodes induce large multinucleated cells, designated giant cells and syncytia, respectively, in plant roots. We have used molecular markers to study cell cycle progression in these specialized feeding cells. In situ hybridization with two cyclin-dependent kinases and two cyclins showed that these genes were induced very early in galls and syncytia and that the feeding cells progressed through the G2 phase. By using cell cycle blockers, DNA synthesis and progression through the G2 phase, or mitosis, were shown to be essential for gall and syncytium establishment. When mitosis was blocked, further gall development was arrested. This result demonstrates that cycles of endoreduplication or other methods of DNA amplification are insufficient to drive giant cell expansion. On the other hand, syncytium development was much less affected by a mitotic block; however, syncytium expansion was inhibited.  (+info)

Ti plasmids from Agrobacterium characterize rootstock clones that initiated a spread of crown gall disease in Mediterranean countries. (2/273)

Crown gall caused by Agrobacterium is one of the predominant diseases encountered in rose cultures. However, our current knowledge of the bacterial strains that invade rose plants and the way in which they spread is limited. Here, we describe the integrated physiological and molecular analyses of 30 Agrobacterium isolates obtained from crown gall tumors and of several reference strains. Characterization was based on the determination of the biovar, analysis of 16S ribosomal DNA restriction fragment length polymorphisms by PCR (PCR-RFLP), elucidation of the opine type, and PCR-RFLP analysis of genes involved in virulence and oncogenesis. This study led to the classification of rose isolates into seven groups with common chromosome characteristics and seven groups with common Ti plasmid characteristics. Altogether, the rose isolates formed 14 independent groups, with no specific association of plasmid- and chromosome-encoded traits. The predominant Ti plasmid characteristic was that 16 of the isolates induced the production of the uncommon opine succinamopine, while the other 14 were nopaline-producing isolates. With the exception of one, all succinamopine Ti plasmids belonged to the same plasmid group. Conversely, the nopaline Ti plasmids belonged to five groups, one of these containing seven isolates. We showed that outbreaks of disease provoked by the succinamopine-producing isolates in different countries and nurseries concurred with a common origin of specific rootstock clones. Similarly, groups of nopaline-producing isolates were associated with particular rootstock clones. These results strongly suggest that the causal agent of crown gall disease in rose plants is transmitted via rootstock material.  (+info)

Cell-division factors from Vinca rosca L. crown gall tumor tissue. (3/273)

A cell-division factor has been precipitated from extracts of cultured Vinca rosea L. crown gall tumor tissue by using the mercuric acetate procedure previously employed by Wood and colleagues to obtain their "cytokinesin I." On the basis of its mass spectrum, ultraviolet light absorbancy spectra, solubilities, chromatographic migration values, and growth activity, the factor is ribosyl-trans-zeatin, that is, 6-(4-hydroxy-3-methyl-trans-2-butenylamino)-9-beta-D-ribofuranosylpurine. Ribosylzeatin has now been isolated from tumor tissue by four experimental techniques; any possibility that it is an artifact seems to have been eliminated. Contrary to the report by Wood and colleagues, synthetic ribosylzeatin is precipitated from an aqueous solution by mercuric acetate, provided the complete precipitation procedure is utilized. These facts and others discussed strongly support our suggestion that ribosylzeatin was present in the preparation ("cytokinesin I") examined by Wood and colleagues in several biological assays. The reasons advanced by Wood and others for rejecting this suggestion have been found either not to be pertinent to the question or to have insufficient experimental bases.  (+info)

An inherited "neoplasm" in fungus. (4/273)

An abnormal growth form in the fungus Schizophyllum commune is described that interferes with the development of reproductive structures. The abnormality, which takes the form of relatively large, compact, hemispherical bodies, depends on a dominant Mendelian gene, mound, for its expression. When mound is expressed in a mycelium that has the potential to form fruiting bodies, the fruiting response is affected and the effect is variable within a replicate series: fruiting bodies may be normal or abnormal, abort at various stages, or not develop at all. Occasionally, fruit bodies are overgrown and are completely enveloped by the hemispherical bodies. When hyphae from hemispherical bodies are subcultured, a seemingly normal mycelium forms that eventually differentiates hemispherical structures, but the ability to form fruiting bodies in not expressed. Continuous mycelial subculture has shown this loss of fruiting expression to be a permanent transformation, which is demonstrated to be a characteristic of hemispherical bodies.  (+info)

Suppression of the neoplastic state with the acquisition of specialized functions in cells, tissues, and organs of crown gall teratomas of tobacco. (5/273)

The neoplastic state in cells of tissues and organs that develop from cloned lines of crown gall teratomas of tobacco may be completely but reversibly suppressed. Stems and leaves found on teratoma shoots may appear morphologically normal and such organs contain all of the specialized cell types and are histologically and functionally indistinguishable from those found in normal tobacco shoots of comparable age. When however, specialized cells of several different kinds that are present in stems and leaves of the teratomas are excised from the plant and grown on a basic culture medium they again assume their neoplastic properties. The results of this study indicate that the morphogenetic factors and mechanisms that govern so precisely growth, cellular differentiation, and organogenesis during the normal course of development can completely suppress the tumorous state, leading to the formation of cells, tissues, and organs that appear normal in every respect but are, in fact, inherently neoplastic. Whether the normal or tumor phenotype is expressed appears to depend on the activation or repression of select biosynthetic systems, one of which, the auxin sytems, has been identified here.  (+info)

High relatedness and inbreeding at the origin of eusociality in gall-inducing thrips. (6/273)

Within the haplodiploid eusocial gall-inducing thrips, a species-level phylogeny combined with genetic data for five eusocial species enables an inference of levels of relatedness and inbreeding values for lineages at the origin of eusociality. Character optimization using data from five eusocial species indicates that the lineage or lineages where eusociality is inferred to have originated exhibit relatedness of 0.64-0.92, and F(IS) of 0.33-0.64. The high inbreeding coefficients found in these eusocial thrips have increased relatedness among and within both sexes and have reduced the haplodiploidy-induced relatedness asymmetries [Hamilton, W. D. (1964) J. Theor. Biol. 7, 1-52]. These results indicate that unusually high relatedness is associated with the origin of eusociality, and they suggest a role for inbreeding in the evolution of bisexual helping.  (+info)

Bruchins: insect-derived plant regulators that stimulate neoplasm formation. (7/273)

Pea weevil (Bruchus pisorum L.) oviposition on pods of specific genetic lines of pea (Pisum sativum L.) stimulates cell division at the sites of egg attachment. As a result, tumor-like growths of undifferentiated cells (neoplasms) develop beneath the egg. These neoplasms impede larval entry into the pod. This unique form of induced resistance is conditioned by the Np allele and mediated by a recently discovered class of natural products that we have identified from both cowpea weevil (Callosobruchus maculatus F.) and pea weevil. These compounds, which we refer to as "bruchins," are long-chain alpha,omega-diols, esterified at one or both oxygens with 3-hydroxypropanoic acid. Bruchins are potent plant regulators, with application of as little as 1 fmol (0.5 pg) causing neoplastic growth on pods of all of the pea lines tested. The bruchins are, to our knowledge, the first natural products discovered with the ability to induce neoplasm formation when applied to intact plants.  (+info)

Leifsonia poae gen. nov., sp. nov., isolated from nematode galls on Poa annua, and reclassification of 'Corynebacterium aquaticum' Leifson 1962 as Leifsonia aquatica (ex Leifson 1962) gen. nov., nom. rev., comb. nov. and Clavibacter xyli Davis et al. 1984 with two subspecies as Leifsonia xyli (Davis et al. 1984) gen. nov., comb. nov. (8/273)

The new genus Leifsonia gen. nov. with two new species, Leifsonia poae sp. nov. (type strain VKM Ac-1401T) and Leifsonia aquatica (ex Leifson 1962) nom. rev., comb. nov. (the type species, with VKM Ac-1400T = DSM 20146T = JCM 1368T as type strain), is proposed to accommodate bacteria found in Poa annua root gall, induced by the nematode Subanguina radicicola, and 'Corynebacterium aquaticum' Leifson 1962. Further, it is proposed to reclassify Clavibacter xyli Davis et al. 1984 with two subspecies in the new genus as Leifsonia xyli (Davis et al. 1984) comb. nov., Leifsonia xyli subsp. xyli (Davis et al. 1984) comb. nov. and Leifsonia xyli subsp. cynodontis (Davis et al. 1984) comb. nov. Members of the proposed genus are characterized by coryneform morphology, peptidoglycans based upon 2,4-diaminobutyric acid, the major menaquinone MK-11, phosphatidylglycerol and diphosphatidylglycerol as principal phospholipids, the high content of anteiso- and iso-branched saturated fatty acids, and a DNA G+C base composition of 66-73 mol%. They form a distinct phylogenetic branch attached to the line of descent of Agromyces spp. The new and reclassified species of the new genus clearly differ from each other phylogenetically and phenetically and can be recognized by their morphologies, the cell wall sugar composition, the requirement of complex media for growth, and numerous physiological characteristics, including the oxidase reaction.  (+info)

Octopine and nopaline strains of Agrobacterium tumefaciens differ in their ability to induce tumors on Nicotiana glauca. The presence of a virF locus on the octopine Ti plasmid makes N. glauca a host plant for these strains, indicating that the VirF protein is a host-range determinant. Here we show the presence of a virF locus not only on the Agrobacterium vitis octopine/cucumopine plasmids pTiAg57 and pTiTm4, but also on the nopaline Ti plasmids pTiAT1, pTiAT66a, and pTiAT66b. On the octopine Ti plasmids from A. tumefaciens the virF gene is located between the virE locus and the left border of the T-region. In contrast, the virF gene on Ti plasmids of A. vitis is located at the very left end of the vir-region near the virA locus. The virF gene of pTiAg57 has been sequenced and codes for a protein of 202 amino acids with a molecular mass of 22,280 Da. Comparison showed that the virF gene from A. vitis strain Ag57 is almost identical to that from A. tumefaciens octopine strains. The transcription of the
Several lines of evidence show that cancer progression can be elicited by reversible epigenetic changes as well as by irreversible mutations in oncogenic and tumor suppressor genes (Esteller, 2007). The first experimental evidence of tumor reversibility was described in crown‐gall tumors in plants over a half century ago (Braun, 1959). Braun had hypothesized that the individual pluripotent teratoma cells of crown‐gall tumors might be recovered from the cancer in grafting experiments. To test his idea, he grafted the shoots from crown‐gall teratoma cells serially to the cut stem ends of the healthy tobacco plants. The grafted teratoma tissue gradually developed more normal appearing shoots, which eventually flowered and developed seeds. He concluded that the cellular alteration in crown gall did not involve a somatic mutation at the nuclear gene level and rather some yet uncharacterized cytoplasmic entity is responsible for the cellular changes that underlie the tumorous state in the ...
Im Bob Larson. Researchers at Oregon State University are one step closer to developing a system to detect, on-site, a soil-borne bacterium found in fruit and nut trees and grapevines.OSU Ag Sciences professor Jeff Chang says researchers have developed molecular tools that work with commercially av
Comparison of T-DNA oncogene complements of Agrobacterium tumefaciens tumor-inducing plasmids with limited and wide host ranges.: The T-DNA oncogene complements
Principal Investigator:WABIKO Hiroetsu,我彦 廣悦, Project Period (FY):1993 - 1995, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:遺伝
Agrobacterium vitis, the cause of crown gall disease on grapevine, survives internally in vines and can be spread in cuttings for propagation. The possibility of generating pathogen-free vines through tissue culture makes it essential to understand the distribution of the pathogen in grapevines. A highly sensitive magnetic capture hybridization procedure along with real-time polymerase chain react ...
Plant galls provide a fascinating array of color and texture on many of the plants in our California landscape. Galls, growths of plant cells that are not normal plant organs, can be induced by a number of organisms. The most numerous as well as most beautiful and intriguing are those induced by insects. Two insect families are found only in plant galls: Cynipidae (gall wasps) and Cecidomyiidae (gall midges or gnats). Plant galls also host a whole ecology of other insects, including herbivorous inquilines and carnivorous parasitoids like the wasp family Ormyridae, which is found only in plant galls. Most of these organisms are too small for us to see, so that the only thing we notice is the colorful gall growth itself.. In this workshop, we will start by exploring the diversity of extant insect-induced plant galls and the community of species found within them. Our study will begin with a series of lectures covering gall induction, development, plant host specificity, and inducer life histories ...
In yeast, there are at least two vesicle populations upon ER (endoplasmic reticulum) exit, one containing Gap1p (general aminoacid permease) and a glycosylated α-factor, gpαF (glycosylated proα-factor), and the other containing GPI (glycosylphosphatidylinositol)-anchored proteins, Gas1p (glycophospholipid-anchored surface protein) and Yps1p. We attempted to identify sorting determinants for this protein sorting event in the ER. We found that mutant Gas1 proteins that lack a GPI anchor and/or S/T region (serine- and threonine-rich region), two common characteristic features conserved among yeast GPI-anchored proteins, were still sorted away from Gap1p-containing vesicles. Furthermore, a mutant glycosylated α-factor, gpαGPI, which contains both the GPI anchor and S/T region from Gas1p, still entered Gap1p-containing vesicles, demonstrating that these conserved characteristics do not prevent proteins from entering Gap1p-containing vesicles. gpαF showed severely reduced budding efficiency in ...
An automated algorithm and methodology is presented to identify tumor-tissue morphologies based on broadband scatter data measured by raster scan imaging of the samples. A quasi-confocal reflectance imaging system was used to directly measure the tissue scatter reflectance in situ, and the spectrum was used to identify the scattering power, amplitude, and total wavelength-integrated intensity. Pancreatic tumor and normal samples were characterized using the instrument, and subtle changes in the scatter signal were encountered within regions of each sample. Discrimination between normal versus tumor tissue was readily performed using a K-nearest neighbor classifier algorithm. A similar approach worked for regions of tumor morphology when statistical preprocessing of the scattering parameters was included to create additional data features. This type of automated interpretation methodology can provide a tool for guiding surgical resection in areas where microscopy imaging cannot be realized efficiently by
The data show that patterns of gene expression obtained from DNA microarray studies of crudely dissected lung tumors can be used to detect tumor subtypes that correlate with biological and clinical phenotypes. Specifically, patterns of gene expression were found that correspond to the major morphological classes of lung tumors. In addition, we were able to define three subgroups of AC that differed not only in gene expression patterns, but also in clinical and pathological properties, including patient survival.. The survival differences we found among the AC tumors corresponded only in part to differences in stage and grade. In particular, AC group 2 included a number of high-grade tumors that nevertheless did not result in poor survival. For these cases, tumor morphology was not indicative of patient survival. In general, it is important to note that histological grading of lung cancer is biased by interobserver variability and does not influence the course of therapy. The genes that correlate ...
Heres the latest from NOTCOTs London-based editor and resident zoologist, Justine Aw.. As we move into late summer, fruits and nuts seem to be forming everywhere in all sorts of shapes and colors. While walking through London, these oddly-shaped green acorns caught my eye, with their ridges, knobs and slightly sticky appearance. On closer inspection, most of the acorns were covered with these intricate, ridged growths, called Knopper Galls. The galls result from a chemical reaction in response to the gall wasp (Andricus quercuscalicis), which lays its eggs on the developing acorns. The shapes and textures of the resulting galls are fascinating (and quite variable). The degree of ridging on the gall is thought to be related to the number of larvae competing within the gall and we found as many as three separate galls on a single developing acorn. Their name Knopper Galls comes is thought to be derived from the English word knop, meaning a small rounded protuberance, boss, stud, button, ...
Note that UU095 and UU096 are both similar to H.pylori hsdR and hsdS proteins.? UU096 has a high A+T region near the 5 end of the cds. Note that the start aa is tyrosine, an aa not known to be used by mycoplasma for a start. Could UU096 fuse with UU097 into a single cds? Note displacement in BLAST with some ortholog starts. UU097 starts with Ile. See UU446 and UU447, other predicted hsdS sequences with noncanonical starts, his and gly ...
UK 6 - US 7 - EU 40, UK 6.5 - US 7.5 - EU 40.5, UK 7 - US 8 - EU 41, UK 7.5 - US 8.5 - EU 41.5, UK 8 - US 9 - EU 42, UK 8.5 - US 9.5 - EU 42.5, UK 9 - US 10 - EU 43, UK 9.5 - US 10.5 - EU 43.5, UK 10 - US 11 - EU 44, UK 10.5 - US 11.5 - EU 44.5, UK 11 - US 12.5 - EU 45.5, UK 11.5 - US 12.5 - EU 45.5, UK 12 - US 13 - EU 46. ...
Crown gall disease caused by Agrobacterium tumefaciens severely impacts the production of peach and other fruit trees. Several peach cultivars are partially resistant to A. tumefaciens, but little is known about the roles of endophytic microbiota in disease resistance. In the present study, the endophytic bacterial communities of resistant and susceptible peach cultivars Honggengansutao and Okinawa were analyzed using universal 16S rRNA gene amplicon sequencing in parallel with cultivation and characterization of bacterial isolates. A total of 1,357,088 high-quality sequences representing 3,160 distinct OTUs (Proteobacteria, Actinobacteria, Bacteroidetes, and Firmicutes) and 1,200 isolates of 20 genera and 305 distinct ribotypes were collected from peach roots and twigs. It was found that factors including plant developmental stage, cultivar, and A. tumefaciens invasion strongly influenced the peach endophytic communities. The community diversity of endophytic bacteria and the abundance of ...
Several Agrobacterium tumefaciens strains have been isolated for their ability to produce D-amino acids from D, L-substituted hydantoins. The optically pure D-amino acids are used in the synthesis of pharmaceuticals, as food additives and as insecticides. This hydrolysis of D, L-substituted hydantoins is catalysed by two hydantoin-hydrolyzing enzymes, an hydantoinase and an N-carbamyl amino acid amidohydrolase. While the hydantoin-hydrolyzing enzymes have been studied in detail, the mechanisms that control expression of the hyu genes have not. The research reported in this work elucidates some of the mechanisms involved in the regulation of the hyu genes in A. tumefaciens strains.. The hydantoin-hydrolyzing enzyme activity from the environmental isolate A. tumefaciens RU-AE01 was characterized. A broad host range vector for the simultaneous analysis of divergent promoters was constructed. The promoter regions responsible for the activation of transcription of hyuH and hyuC were identified by ...
Nesme, X., Leclerc, M.C. & Bardin, R. 1989 PCR detection of an original endosymbiont: the Ti plasmid of Agrobacterium tumefaciens In. Endocytobiology IV, eds.Nardon, P., Gianinazzi- Peason, V., Greines, A.M., Margulis, L. & Smith, D.C, pp. 47-50. Paris: Institute National de Recherche Agronomique ...
As a special phytopathogen, Agrobacterium tumefaciens infects a wide range of plant hosts and causes plant tumors also known as crown galls. The complexity of Agrobacterium-plant interaction has been studied for several decades. Agrobacterium pathogenicity is largely attributed to its evolved capabilities of precise recognition and response to plant-derived chemical signals. Agrobacterium perceives plant-derived signals to activate its virulence genes, which are responsible for transferring and integrating its Transferred DNA (T-DNA) from its Tumor-inducing (Ti) plasmid into the plant nucleus. The expression of T-DNA in plant hosts leads to the production of a large amount of indole-3-acetic acid (IAA), cytokinin (CK), and opines. IAA and CK stimulate plant growth, resulting in tumor formation. Agrobacterium utilizes opines as nutrient sources as well as signals in order to activate its quorum sensing (QS) to further promote virulence and opine metabolism. Intriguingly, Agrobacterium also ...
Agrobacterium are Gram-negative, motile, soil-dwelling plant pathogens with the species name given based on the disease phenotype associated with the bacteria. They invade the crown, roots and stems of a great variety of plants via wounds causing tumors. The diseases are crown gall, hairy root, and cane gall. Some strains possess a wide host range, whereas other possess a very limited host range. The tumor is correlated with the presence of a large tumor-inducing plasmid (Ti plasmid) in the bacteria. Thus A.tumefaciens causes crown gall on many dicotyledonous plants; A.rubi causes crown gall on raspberries; A.vitis gall formation on grapes; A.rhizogenes causes hairy roots; A.radiobacter is avirulent. However the ability to cause disease is associated with transmissible plasmids, and this grouping is easily disrupted when plasmids move from one strain to another. More recently Agrobacterium have been classified into 3 biovars based on physiological and biochemical phenotypes without consideration ...
Agrobacterium are Gram-negative, motile, soil-dwelling plant pathogens with the species name given based on the disease phenotype associated with the bacteria. They invade the crown, roots and stems of a great variety of plants via wounds causing tumors. The diseases are crown gall, hairy root, and cane gall. Some strains possess a wide host range, whereas other possess a very limited host range. The tumor is correlated with the presence of a large tumor-inducing plasmid (Ti plasmid) in the bacteria. Thus A.tumefaciens causes crown gall on many dicotyledonous plants; A.rubi causes crown gall on raspberries; A.vitis gall formation on grapes; A.rhizogenes causes hairy roots; A.radiobacter is avirulent. However the ability to cause disease is associated with transmissible plasmids, and this grouping is easily disrupted when plasmids move from one strain to another. More recently Agrobacterium have been classified into 3 biovars based on physiological and biochemical phenotypes without consideration ...
Agrobacterium are Gram-negative, motile, soil-dwelling plant pathogens with the species name given based on the disease phenotype associated with the bacteria. They invade the crown, roots and stems of a great variety of plants via wounds causing tumors. The diseases are crown gall, hairy root, and cane gall. Some strains possess a wide host range, whereas other possess a very limited host range. The tumor is correlated with the presence of a large tumor-inducing plasmid (Ti plasmid) in the bacteria. Thus A.tumefaciens causes crown gall on many dicotyledonous plants; A.rubi causes crown gall on raspberries; A.vitis gall formation on grapes; A.rhizogenes causes hairy roots; A.radiobacter is avirulent. However the ability to cause disease is associated with transmissible plasmids, and this grouping is easily disrupted when plasmids move from one strain to another. More recently Agrobacterium have been classified into 3 biovars based on physiological and biochemical phenotypes without consideration ...
Abstract: Agrobacterium tumefaciens infects various plants and causes crown gall diseases involving temporal expression of virulence factors. SghA is a newly-identified virulence factor enzymatically releasing salicylic acid from its glucoside conjugate and controlling the plant tumor development. Here we report the structural basis of SghR, a LacI-type transcription factor and highly conserved in Rhizobiaceae family, regulating the expression of SghA and involved in tumorigenesis. We identified and characterized the binding site of SghR on the promoter region of sghA, and then determined the crystal structures of apo-SghR, SghR complexed with its operator DNA and ligand sucrose, respectively. These results provide detailed insights into how SghR recognizes its cognate DNA and shed a mechanistic light on how sucrose attenuates the affinity of SghR with DNA to modulate the expression of SghA. Given the important role of SghR in mediating the signaling crosstalk during Agrobacterium infection, our ...
Willow trees (Salix spp.) enhance pond and river banks with their many graceful forms. These trees suffer from few diseases, but are often plagued by crown gall. The trunk and root deformations ...
This monograph, a set of 2 volumes places greater emphasis on the biology, behavior, and evolution of the gall-inducing arthropod and of associated organisms; the dynamics of the host-plant response remain in the background. The book deals with the biology and ecology of acarines, hemipteroids, coleopteroids and hymenopteroids. It also includes chapters on the biology, ecology, and evolution of several minor or less-known groups of gall inducers. A special effort has been made to incorporate extensive chapters on gall-inducing Coleoptera, chloropids, and chalcidoids including the braconids and fig wasps. Chapters on whiteflies and dipteran leafminers should broaden our understanding of the galling habit in other groups of arthropods. In addition to the biological and ecological informa-tion on these arthropods, each chapter also provides information on their evolution, in most instances, viewed against the evolution of their host plants ...
Dear Jamie, Cnacer is typically a disease only found in the Animal kingdom. It is caused by a mutation in either a tumour supressor gene or a mutation of an oncogene. This mutation causes the rapid growth of cells and they dont specialize. A good link to find out more about the genetics of cancer is http://www.cancergenetics.org/ As for your question about what cancer looks like in plants I think you are referring ot a disease called Crown Gall Disease. Plants dont get the cancer. They do get tumour-like growths that look like they could be cancer and that are cuased by uncontrolled growth but it is not due to an error in copying the gene. It is cuase by a bacterium called Agrobacterium tumefaciens. This baceria actually inserts a piece of its DNA into the plant cells DNA and causes it to grow really fast. A link that you may want to check out for more info on this is http://helios.bto.ed.ac.uk/bto/microbes/crown.htm There are several photos of the disease on this site as well. I couldnt find ...
Insect galls are unique organs that provide shelter and nutrients to the gall-inducing insects. Although insect galls are fascinating structures for their unique shapes and functions, the process by which gall-inducing insects induce such complex structures is not well understood. Here, we performed RNA-sequencing-based comparative transcriptomic analysis of the early developmental stage of horned gall to elucidate the early gall-inducing process carried out by the aphid, Schlechtendalia chinensis, in the Chinese sumac, Rhus javanica. There was no clear similarity in the global gene expression profiles between the gall tissue and other tissues, and the expression profiles of various biological categories such as phytohormone metabolism and signaling, stress-response pathways, secondary metabolic pathways, photosynthetic reaction, and floral organ development were dramatically altered. Particularly, master transcription factors that regulate meristem, flower, and fruit development, and biotic and abiotic
Agrobacterium vitis and some strains of A. tumefaciens and A. rhizogenes cause a dangerous chronic disease on grape plants-crown gall. Molecular-genetic methods were used in the work to identify and study the diversity of pathogenic agrobacteria that cause crown gall in the vineyards of Krasnodar krai. The research material was 76 samples of young and lignified tumor-like outgrowths of crown gall ...
The biotrophic fungus Ustilago maydis causes smut disease on maize (Zea mays), which is characterized by immense plant tumours. To establish disease and reprogram organ primordia to tumours, U. maydis deploys effector proteins in an organ-specific manner. However, the cellular contribution to leaf t …
Author: Willmitzer, L.; Genre: Meeting Abstract; Published in Print: 1984; Title: The Ti Plasmid of Agrobacterium Tumefaciens - a Plant-Oriented Gene Vector
Plant material and transformation: Plants were grown in peat soil with 18 hr light and 6 hr dark. DNA constructs were transformed into Agrobacterium tumefaciens strain C58 and then transformed into Arabidopsis plants by the floral dip method (Clough and Bent 1998).. Plasmid construction: Tag1 promoter-GUS expression plasmids were constructed as follows. The pTPG2 and pTPG3 plasmids were generated by PCR amplifying 1- to 262-bp and 1- to 548-bp fragments, respectively, from the 5′ end of Tag1 into the XbaI and BamHI restriction sites of the pBI101.3 GUS expression vector (accession no. U12640). pTPG4 was made by ligating a XbaI-ScaI Tag1 fragment (1-1251 bp of Tag1) from the pBT1 plasmid (Liuet al. 2001a), which contains Tag1 in the BlueScript vector (Stratagene, La Jolla, CA), into the XbaI-SmaI sites of pBI101.3 to generate an in-frame fusion between the Tag1 transposase and GUS. pTPG5 was made by ligating a XbaI-NdeI 5′ Tag1 fragment (1-1950 bp of Tag1 in pBT1) into the XbaI and BamHI ...
Galls are growths on the surface of plants and other lifeforms. They are caused by various parasites, such as fungi, bacteria, insects and mites. Plant galls are abnormal growths of plant tissues similar to benign tumors or warts in animals.[1] What causes a plant gall can often be known without the actual agent being there. Many types of gall have typical structures. This is true of many galls produced by insects and mites. Insect galls on plants give some herbivorous insects their own microhabitat. They are plant tissue which is controlled by the insect. Galls are the habitat and food source for the maker of the gall. The gall may contain nutritious starch and other tissues.[2] Galls often give the insect physical protection from predators.[3][4] Insect galls are usually induced by chemicals injected by the larvae or the adults of the insects into the plants, and possibly by mechanical damage. After the galls are formed, the larvae develop inside until fully grown, when they leave. In order to ...
Nopaline is a chemical compound derived from the amino acids glutamic acid and arginine. It is classified as an opine. Ti plasmids are classified on the basis of the different types of opines they produce. These may be nopaline plasmids, octopine plasmids and agropine plasmids. These opines are condensation products of amino acids and keto acids or may be derived from sugars. The opines are used as carbon and nitrogen sources and metabolized by Agrobacterium. PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/ ...
END+. title=Click here to sort href=javascript:__doPostBack(ctl01$TemplateBody$WebPartManager1$gwpcieLinks$cieLinks$ResultsGrid$Grid1$ctl00$ctl02$ctl01$btn_ResultsGrid_2_Sort_,h4>Digital_Options:,/h4>,p>+CASE_WHEN_LinkAmazon_IS_NULL_OR_LinkAmazon=_THEN__ELSE_,a_href=+LinkAmazon+_title=Purchase_at_Amazon>,img_src=/images/Products/linkAmazon.png_class=bkLink/>,/a>_END+CASE_WHEN_LinkIbook_IS_NULL_OR_LinkIbook=_THEN__ELSE_,a_href=+LinkIbook+_title=Purchase_iBook>,img_src=/images/Products/linkIbook.png_class=bkLink/>,/a>_END+CASE_WHEN_LinkOnline_IS_NULL_OR_LinkOnline=_THEN__ELSE_,a_href=+LinkOnline+_title=Purchase_eBook>,img_src=/images/Products/linkOnline.png_class=bkLink/>,/a>_END+,/p ...
We study tumour morphological stability by employing three mathematical models to gain insight into tumour invasion and metastasis, and to evaluate the consistency between the model predictions and experimental observations. There has been extensive progress in employing mathematical modelling to study solid tumour growth over the past few decades, and this work has provided insight into the understanding of experimental and clinical data. Most models fall into two categories, discrete cell-based and continuum models (see recent reviews [1-19]). For example, models have been applied to brain cancer (e.g. [20-22]) and breast cancer (e.g. [23,24]). Furthermore, modelling has shown that tumour morphology may serve as a predictor of invasiveness [11,19,25-29]. In particular, Byrne & Chaplain [30,31] revealed that cell-cell adhesion and external nutrient concentration are key parameters controlling the stability of three-dimensional multicellular spheroids. Extending this work, Cristini et al. [25] ...
virA and virG are the Ti-plasmid functions required for chemotaxis of Agrobacterium tumefaciens towards acetosyringone (pages 413-417). C. H. Shaw, A. M. Ashby, A. Brown, C. Royal, G. J. Loake and C. M. Shaw. Version of Record online: 27 OCT 2006 , DOI: 10.1111/j.1365-2958.1988.tb00046.x. ...
Virts, E.L. and Gelvin, S.B. (1995). Ti-plasmid transfer from Agrobacterium tumefaciens to Petunia cells. In A.A. Szalay and R.B. Legocki (eds.), Advances in the molecular genetics of the bacteria-plant interaction. Media Services, Cornell University, Ithaca, NY ...
Galls or cecidia are a kind of swelling growth on the external tissues of plants or animals. Plant galls are abnormal outgrowths of plant tissues, similar to benign tumors or warts in animals. They can be caused by various parasites, from fungi and bacteria, to insects and mites. Plant galls are often highly organized structures and because of this the cause of the gall can often be determined without the actual agent being identified. This applies particularly to some insect and mite plant galls. The study of plant galls is known as cecidology. In human pathology, a gall is a raised sore on the skin, usually caused by chafing or rubbing. Insect galls are the highly distinctive plant structures formed by some herbivorous insects as their own microhabitats. They are plant tissue which is controlled by the insect. Galls act as both the habitat and food source for the maker of the gall. The interior of a gall can contain edible nutritious starch and other tissues. Some galls act as physiologic ...
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PTIA (Plataforma de Testes de Intrusão Avançada) (TECNOLOGIA (APP (Digital…: PTIA (Plataforma de Testes de Intrusão Avançada)
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Objectives: The objective of this course is to present to potential users the new configuration of MareNostrum and a introduction on how to use the new system (batch system, compilers, hardware, MPI, etc).Also It will provide an introduction about RES and PRACE infrastructures and how to get access to the supercomputing resources available.. ...
Agrobacterium species that are pathogenic on plants, including Agrobacterium tumefaciens, A. vitis, A. rubi, and A. rhizogenes, all carry megaplasmids. By contrast, nonpathogenic strains either lack these plasmids entirely or carry mutant forms of plasmids. A strict requirement of the Ti plasmid for virulence was established through mutational analyses and by a demonstration that the introduction of Ti plasmids into Rhizobium or Phyllobacterium spp. converts these nonpathogenic species into tumor-inducing pathogens ( 2 , 3 ). Ti plasmids induce a disease called crown gall, which is typified by the formation of undifferentiated plant tumors at the plant crown (the subterranean-to-aerial transition zone). The related root-inducing or Ri megaplasmids carried by A. rhizogenes instead induce hairy root disease, which is typified by the formation of entangled masses of roots at the infection site ( 4 ).
Transformed Arabidopsis thaliana plants have been produced by a modified leaf disk transformation-regeneration method. Leaf pieces from sterilely grown plants were precultured for 2 days and inoculated with an Agrobacterium tumefaciens strain containing an avirulent Ti (tumor-inducing) plasmid with a chimeric gene encoding hygromycin resistance. After cocultivation for 2 days, the leaf pieces were placed on a medium that selects for hygromycin resistance. Shoots regenerated within 3 months and were excised, rooted, and transferred to soil. Transformation was confirmed by opine production, hygromycin resistance, and DNA blot hybridization of both primary transformants and progeny. This process for producing transgenic Arabidopsis plants should enhance the usefulness of the species for experimental biology. |P /|
Abstract. The broad host range pathogenic bacterium Agrobacterium tumefaciens has been widely studied as a model system to understand horizontal gene flow, secretion of effector proteins into host cells, and plant-pathogen interactions. Agrobacterium-mediated plant transformation also is the major method for generating transgenic plants for research and biotechnology purposes. Agrobacterium species have the natural ability to conduct interkingdom genetic transfer from bacteria to eukaryotes, including most plant species, yeast, fungi, and even animal cells. In nature, A. tumefaciens causes crown gall disease resulting from expression in plants of auxin and cytokinin biosynthesis genes encoded by the transferred (T-) DNA. Gene transfer from A. tumefaciens to host cells requires virulence (vir) genes that reside on the resident tumor-inducing (Ti) plasmid. In addition to T-DNA, several Virulence (Vir) effector proteins are also translocated to host cells through a bacterial type IV secretion ...
44,203-229. , Hirsch, P. , Hooykaas, P J J , and Schilperoort, R. A (1983) A binary plant vector strategy based on separation of vir- and T-region of the Agrobacterium tumefaciens Tr-plasmrd. Nature 303, 179,180. 8. Stachel, S. E and Nester, E W. (1986) The genetic and transcriptional organization of the vir region of the A6 TI plasmid of Agrobacterium tumefaciens. EMBO J. $1445-1454 9. Stachel, S E and Zambryski, P (1986) virA and virG control the plant-induced activation of the T-DNA transfer process of Agrobacterium tumefaciens. Biol. Rep. 10, 12-36. &APTER 7 Leaf Disk Transformation Ian S. Curtis, Michael R. Davey, and J. Brian Power 1. Introduction Reliable and efficient methods of transferring cloned genes into plants are essential for engineering crops with desired traits. The Gram-negative soil bacteria, Agrobacterium tumefaciens and A. rhizogenes, are natural genetic engineers, capable of transforming a range of dicotyledonous plants by transferring plasmid-encoded genes into recipient ...
Ustilago maydis, a facultative biotrophic basidiomycete fungus, causes smut disease in maize. A hallmark of this disease is the induction of large plant tumours that are filled with masses of black-pigmented teliospores. During the last 15 years U. maydis has become an important model system to unravel molecular mechanisms of fungal phytopathogenicity. This review highlights recent insights into molecular mechanisms of complex signalling pathways that are involved in the transition from budding to filamentous growth and operate during the pathogenic growth phase. In addition, we describe recent progress in understanding the structural basis of morphogenesis and polar growth in different stages of U. maydis development. Finally, we present an overview of recently identified genes related to pathogenic development and summarize novel molecular and genomic approaches that are powerful tools to explore the genetic base of pathogenicity ...
Escribed . Briefly, the AtEHD constructs were cloned in pBINplus and introduced by electroporation into Agrobacterium tumefaciens strain GV3101. Agrobacterium
when virulent cells of agrobacterium tumefaciens strain b6 were exposed to low-level microwave radiation at a frequency of 10,000 mhz and an intensity of 0.58 mw/cm2 for 30 to 120 min, a 30 to 60% decrease in their ability to produce tumors on potato and turnip disks was observed. this microwave exposure did not affect the viability of these bacteria or their ability to attach to a tumor-binding site nor did it induce thermal shock. this loss of virulence was reversible within 12 h ...
Crown gall is a widespread disease of cultivated culture all over the world. The bacterial pathogen Agrobacterium tumefacience colonize the xylem vessels of the plants.The tumors form in stems and roots of fruits culture. Large tumoursmay death of new plants in the nursery and in the plantation. Tumouregenesis causing root decay may be factor involved in the complex syndrome. Development of measures to controle crown-gall is carried out in direction for obtaining tumorless plants at the expens of preventive treatment of woundings so as to deteriorate the interaction of pathogen with the cell of host plant. Utilization the strain of soil inhibiting Pseudomonas fluorescens CR- 330 D which synthesize the substances (bacteriocins) with preventing activity to nopaline and octopine strains of pathogenic agrobacteria. Liquid concentrate suspension of this bacteria - biological preparat , Paurin, -were applicated for preplanting treatment of rooted saplings. Using to treat apple MM-106 wilding prior to ...
Gall wasps (family Cynipidae) are likely the most common gall-making insects. Heres more about gall wasps, and which plants they affect.
ALIPPI, Adriana M; LOPEZ, Ana C y BALATTI, Pedro A. Methods for the detection of Agrobacterium from plant, soil and water samples. Rev. argent. microbiol. [online]. 2011, vol.43, n.4, pp. 278-286. ISSN 0325-7541.. The genus Agrobacterium includes phytopathogenic bacteria that induce the development of root crown galls and/or aerial galls at the base of the stem or hairy roots on more than 600 species of plants belonging to 90 dicotyledonous families and non-pathogenic species. These bacteria being natural soil inhabitants are particularly diffcult to eradicate, which is a problem in nurseries where more than 80% of infections occur. Since early detection is crucial to avoid the inadvertent spread of the disease, the aim of this work was to develop sensitive and precise identifcation techniques by using a set of semi-selective and differential culture media in combination with a specifc PCR to amplify a partial sequence derived from the virC operon, as well as a multiplex PCR on the basis of ...
Indeed, taking a gene from a soil bacterium (Bacillus thuringiensis - Bt) that produces a natural pesticide and injecting that gene into the DNA of a soy plant, is hardly Mother Natures way of hybridising plants. Ummmm...FAIL! Sorry, that is EXACTLY how Mother Gaia engineers plants, via Agrobacterium tumefaciens: that bug causes crown gall by inserting DNA into the host plant cells that provides a nice little niche environment for the bacterium to grow.. In fact, if people actually understood just how much other DNA finds its way into plant genomes, they would lose all fear of GMOs. Or, alternatively, not eat anything ever again - which wwould be a fitting Darwinian punishment for stupidity.. Seriously: just the tobacco (Nicotiana tabacum) genome, for example, contains genes or sequences derived from Agrobacterium, from plant-infecting single-stranded DNA geminiviruses, from single-stranded RNA potyviruses, from insects that feed on plants, and from other bacteria and probably from fungi. ...
Grapevines are susceptible to numerous diseases harming both plants and profits. Transgenic grapevines that resist disease would provide better disease control as well as economic benefits from the reduction in spray applications. Our overall goal has been to research and develop methods to create transgenic selections of elite cultivars with improved resistance to diseases. The transgenic strategy is especially appropriate for clonally-propagated crops, such as grapevines, where the wine industry is rooted in traditional European grapes with strong name recognition and very high disease susceptibility. During the past year, we screened six different antimicrobial peptides, which are small proteins known to be inhibitory to a range of bacteria and fungi, to determine which might best provide resistance to bunch rot (Botrytis) and crown gall (Agrobacterium vitis). These same peptides are also being tested for their effects on germinationof powdery mildew conidia. Based on the incoming results ...
Molecular Farming. Similar to the viral vector system, transient gene expression via agroinfiltration is a fast, flexible and reproducible approach to high-level expression of useful proteins. Here recombinant strains of Agrobacterium tumefaciens can be used for transientexpression of genes that have been inserted into the T-DNA region of the bacterial Ti plasmid. However, the utility of the system is limited because the ectopic protein expression ceases after 2-3 days. In many cases post-transcriptional gene silencing (PTGS) is a major cause for this lack of efficiency.. A system based on co-expression of a viral-encoded suppressor protein which originally represents a viral adaptation to a novel host antiviral defense via gene silencing. The suppressor proteins of different viruses, are analysed for their ability to prevent the onset of post-transcriptional gene silencing in the infiltrated tissues and thus allow high level of transient expression. Due to its simplicity and efficiency, we ...
Grape phylloxera (Daktulosphaira vitifoliae Fitch, Homoptera: Phylloxeridae) a global pest feed and induce galls on roots and leaves of susceptible varieties of Vitis ssp. causing tremendous damage in viticulture. Genomic approaches to understand the expression of genes that provide data on the physiological networks and signaling behind insect induced gall formation in plants are scarce. With the sequencing of the Vitis genome studies of the phylloxera Vitis interaction provide an opportunity to understand how host plant genetics affects fundamental sink-source relationships, plant-based defense responses and susceptibility to galling insects using microarray or qPCR approaches. Here, we introduce a newly designed microarray of the rootstock Teleki 5C (V. berlandieri × V. riparia) by using the well-established Agilent platform and provide a robust analysis method to determine differential gene expression ...
As you know I called Vitaly Citovsky last week to inquire about experiments on humans with agrobacterium tumefaciens. Even though his last report said that this bacteria could be spread to humans, he reputed now the fact in our conversation. So I checked out his book, Agrobacterium, from biology to biotechnology by Tzfira and Citovsky. In his book it states that over 80 different non plant species can be transformed by agrobacterium. Agrobacteria isnt restricted to eukaryotes. It is capable of transferring not only DNA but also proteins to host organisms. It genetically transforms several types of human cells. Human cancer cells along with neuron and kidney cells were transformed ...
WISTERIA DISEASES Crown gall causes formation of galls on the main roots or stems. There is no chemical control. Remove and destroy infected plants.
Postdoctoral position to study the molecular mechanism of the early events in the transfer of the Agrobacterium tumefaciens Ti-plasmid to plant cells. Candidates should have experience in molecular biology/recombinant DNA technology and/or microbiology. The position is available immediately at an initial annual salary of $16,500. Please contact: Dr. Stanton B. Gelvin, Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA (317) 494-4939.
Living up to its name, the cherry gall wasp produces growths, or galls, on oak leaves that look like red cherries. Inside the gall, the larvae of the wasp feed on the host tissues, but cause little damage.
Living up to its name, the cherry gall wasp produces growths, or galls, on oak leaves that look like red cherries. Inside the gall, the larvae of the wasp feed on the host tissues, but cause little damage.
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Agrocin+, nontumorigenic (Burr, T. J., Reid, C. L., Tagliati, E., Bazzi, C., and Sule, S., 1997. Biological control of grape crown gall by strain F2/5 is not associated with agrocin production or competitions for attachment sites on grape cells. Phytopathology 87:706-711 ...
Hafellner, Josef. Studies in lichenicolous fungi and lichens XII: On the genus Trematosphaeriopsis (Dothideales). Mycotaxon 80: 381-387. 2001.. ABSTRACT: The monotypic ascomycete genus Trematosphaeriopsis is reinvestigated and accepted as a separate genus. It is founded on the lichenicolous, gall-inducing species Trematosphaeriopsis parmeliana, which grows exclusively on Xanthoparmelia species. Originally known only from Asia, it is reported here also from Europe, Africa, North and South America.. KEYWORDS: Lichenicolous Ascomycotina, Xanthoparmelia, taxonomy. NOMENCLATURAL NOVELTIES ...
This HMM represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by PF00528, binding-protein-dependent transport systems inner membrane component. The region covered by this HMM generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline ...
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"Plant Tumors" by people in Harvard Catalyst Profiles by year, and whether "Plant Tumors" was a major or minor topic of these ... Plant tumors or galls usually form in response to the action of a pathogen or a pest. (Holliday, P., A Dictionary of Plant ... "Plant Tumors" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Plant Tumors" by people in Profiles. ...
Ricin, the plant RIP prototype that comprises a catalytic A subunit linked to a galactose-binding lectin B subunit to allow ... The most promising way to exploit plant RIPs as weapons against cancer cells is either by designing molecules in which the ... Here, we will provide a comprehensive picture of plant RIPs and discuss successful designs and features of chimeric molecules ... toxic domains are linked to selective tumor targeting domains or directly delivered as suicide genes for cancer gene therapy. ...
Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice.. Shukla S1, Wen AM, Ayat NR, ... Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice ... Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice ... Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice ...
Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants.. Brioudes F1, Thierry ... Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants ... Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants ... Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants ...
Cushing Disease is caused by a tumour in the pituitary gland in the brain. The tumour secrets increased amounts of the stress ... Treatment with a plant extract alleviates symptoms of Cushing Disease caused by a tumour in the brain, scientists say. ... Plant extract may help fight brain tumour 13th February, 2015 09:54:55 ... BERLIN: Treatment with a plant extract alleviates symptoms of Cushing Disease caused by a tumour in the brain, scientists say. ...
Molecular Plant-Microbe Interactions 13:1034-1040...Julia Krüger , 1 Gabriel Loubradou , 1 Gerhard Wanner , 2 Erika Regenfelder ... In the resulting tumors, the amount of fungal material is drastically reduced and fungal development is arrested at the stage ... tight regulation of the cAMP pathway is crucial for fungal development within the plant but does not interfere with the tumor ... as null mutants in any component of the pathway fail to form tumors. Here we show that moderate activation of the pathway ...
Crown-gall tumor initiation by Agrobacterium tumefaciens is inhibited by cell walls from normal dicotyledonous plants but not ... Cell Walls of Crown-Gall Tumors and Embryonic Plant Tissues Lack Agrobacterium Adherence Sites ... Cell Walls of Crown-Gall Tumors and Embryonic Plant Tissues Lack Agrobacterium Adherence Sites ... Cell Walls of Crown-Gall Tumors and Embryonic Plant Tissues Lack Agrobacterium Adherence Sites ...
Effect of Inhibitors of Plant Cell Division on Mammalian Tumor Cells in Vitro. Shmuel Zilkah, Michael E. Osband and Ronald ... We studied the activity of 14 compounds, all of which have been shown to interfere in plant cell division, in two animal tumor ... These results indicate that some inhibitors of plant cell division are capable of inhibiting the proliferation of animal tumor ... Effect of Inhibitors of Plant Cell Division on Mammalian Tumor Cells in Vitro ...
... *Authors: * ... The present in vitro study demonstrates the antitumor effects of novel plant derived agents in human neuroendocrine tumor cells ... The plant was originally bought at a market in Vietnam. Aerial parts of the plant were successively extracted in ... Neuroendocrine tumors (NETs) represent rare tumors that are derived from cells of the embryonic neural crest. They account for ...
Hardie, D.G. (1999). Plant protein serine/threonine kinases: Classification and functions. Annu. Rev. Plant Physiol. Plant Mol ... L), (P), and (Q) Tinopal/DAPI double-stained mature pollen from a control plant (L) and RNAi plants ([P] and [Q]). Enlarged ... Our study characterized a PTEN homolog in a higher plant and identified its function in pollen development. The PTEN tumor ... Your Name) has sent you a message from Plant Cell Message Body (Your Name) thought you would like to see the Plant Cell web ...
It has been recognized all over the world and plant polysaccharides have anti-tumor effect through their immunomodulating ... The immunomodulating effect and anti-tumor activity of many kinds of plant polysaccharides are introduced in this article. ... The normal immunity system can identify and kill tumor cells, however, the occurrence rate of tumor will enhance if it lacks of ... Research on the Immunomodulation and Anti-tumor Activity of Plant Polysaccharides. GONG Dan~1,DU Pei-ge~2,CUI Xin-ying~2 (1.222 ...
Agrobacterium / Plant tumor / Teratoma / Differential hybridization / Differential display / Regeneration / Wound Stress / ... Search for genes involved in plant tumor and teratoma formation. Research Project ... Unfortunately, resulting transgenic plants did not show any phenotypic abnormality. However, the gene expression was induced by ... We assumed that in these tissues, the genes involved in plant differentiation could be induced or repressed, and thus current ...
Drug candidate shrinks tumor when delivered by plant virus nanoparticle. Chimica Oggi-Chemistry Today ... Inside tumors, the nanoparticles gather inside the lysosomal compartments of cancer cells, where they are, in essence, digested ... The researchers say delivery of the phenanthriplatin into the tumor led to its improved performance over cisplatin or free ... The long, thin tobacco mosaic virus nanoparticles are naturals for delivering the drug candidate into tumors, said Steinmetz, ...
Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study. T. Kohl ... Plant-derived human papillomavirus 16 E7 oncoprotein induces immune response and specific tumor protection. Cancer Res. 62:3654 ... Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study ... Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study ...
In this study, we evaluated the in vitro cytotoxic anti-tumor and immunomodulatory activities and in vivo anti-tumor effect of ... In vivo anti-tumor activity was evaluated in nude mice bearing subcutaneously human Ando-2 melanoma cells. The LACE extract ... Tumor cell lines derived from leukemias, melanomas, fibrosarcomas and cancers of breast, prostate, cervix, lung, pancreas and ... The intraperitoneal injection or oral administration of LACE extract in nude mice inhibits in vivo tumor growth of Ando-2 ...
Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice.: ... Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice.. ... In this study, we used the MUC1 TR peptide as a test antigen to determine whether a plant-expressed human tumour-associated ... The results indicate that a plant-derived human tumour-associated antigen is equivalent to the human antigen in the context of ...
Published on behalf of Japanese Society of Plant Physiologists Volume 39, issue 3, pages 357-360. Published in print March 1998 ... Keywords: Dark induction; Flowering; Pharbitis; Photoperiod; Phytochrome; Translationally controlled tumor protein Journal ... A cDNA encoding a homolog of human translationally controlled tumor protein (TCTP) was isolated from cotyledons of the short- ... A cDNA encoding a homolog of human translationally controlled tumor protein (TCTP) was isolated from cotyledons of the short- ...
... researchers tripled the amount of an antimalarial compound naturally produced by sweet wormwood plants. ... Derailing them could help fight tumors By Esther Landhuis. July 10, 2020. ... News in Brief Plants Genetically modified plant may boost supply of a powerful malaria drug. Researchers tripled the amount of ... More Stories from Science News on Plants * Tech Bubble-blowing drones may one day aid artificial pollination By Maria Temming. ...
... from Tobacco Crown Galls after Deletion of Tumor-Controlling Functions ... Regeneration of Normal and Fertile Plants That Express Octopine Synthase, ... Regeneration of Normal and Fertile Plants That Express Octopine Synthase, from Tobacco Crown Galls after Deletion of Tumor- ... 1982). Regeneration of Normal and Fertile Plants That Express Octopine Synthase, from Tobacco Crown Galls after Deletion of ...
Plant Pathology. Plant nutrient acquisition entices herbivore. *. Working Life. The universe in a classroom ... The exit of metastasizing tumor cells from the vasculature, extravasation, is regulated by their dynamic interactions with the ... From the 2669 unique phosphorylation sites identified, 77 and 43 were differentially phosphorylated in the tumor cells and ... Overall, cell-specific phosphoproteomic analysis provides a bidirectional map of contact-initiated signaling between tumor and ...
Plant Biology. Chimeric plants-the best of both worlds. *. Working Life. Building bridges ... Tumor cell epithelial-mesenchymal transition in response to hypoxia depends on Notch signaling. ... Tumor cell epithelial-mesenchymal transition in response to hypoxia depends on Notch signaling. ...
Plant Pathology. Plant nutrient acquisition entices herbivore. *. Working Life. The universe in a classroom ... This study identifies systemic cross-talk between lung tumors and bones: Lung tumors can remotely activate Ocn+ osteoblastic ... Ocn+ cells affect distant tumor progression because experimentally reducing the number of these cells limits lung tumor growth ... and their ability to modulate tumor progression. Most tumor-infiltrating myeloid cells derive from circulating precursors, ...
Plant Pathology. Plant nutrient acquisition entices herbivore. *. Working Life. The universe in a classroom ... Tumor-associated macrophages limit anti-PD-1 effects by removing the antibody from CD8+ T cells. ... Tumor-associated macrophages limit anti-PD-1 effects by removing the antibody from CD8+ T cells. ... Although anti-PD-1 antibodies initially bound to T cells as intended, the authors found that tumor-associated macrophages ...
Plant Compound Might Wilt Tumors before They Ripen. September 25, 2001 - JR Minkel ...
Tumour imaging with nanoprobes. Dr Fang Xies team in the Department of Materials will develop nanoprobes to image deep tissue ... Growing plants without soil amongst frontier projects backed by Presidents fund. by Hayley Dunning, Caroline Brogan 26 March ... Plant roots naturally seek out water and nutrients, and grow according to gravity. The new materials would be embedded with ... Growing plants without soil. As the global population increases and climate change threatens traditional farming methods, ...
... to fill in as tumor tranquilize conveyance gadgets for mice. However, in a current article distributed… . ... Injectable plant-based nanoparticles postpone progress of tumor, Scientists from Case Western Reserve University School of ... Injectable plant-based nanoparticles postpone progress of tumor. ... into tumor destinations additionally helps stop tumor movement ... The analysts found infusing potato infection particles into melanoma tumor locales actuates a hostile to tumor invulnerable ...
Researchers have said that studying how tumors evolve can help the development of new treatments which can prevent the cancer ... Health Benefits of Dandelion Plant. What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health ... Carcinoid Tumors. Carcinoid tumors is a benign tumor that results in carcinoid syndrome. Only 8 to 10% of all carcinoid tumors ... Brain Tumor. Up to date information about brain tumor, the most common solid tumor in children and the third leading cause of ...
By using experimental drugs scientists were able to stop fibroblasts from stiffening the tissue around tumors. Thus the healthy ... Health Benefits of Dandelion Plant. What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health ... Cancer Cells Disguise as Immune Cells to Spread Secondary Tumors in New Sites. The main reason why people die of cancer is that ... Tumors cause cells, called fibroblasts, to stiffen the surrounding tissue so that cancer cells can grip it. This allows them to ...
... and demonstrate the high potency of extracts of these plants as chemoprotectors against experimental mammary tumors. ... Upper) Tumor incidence (percent of rats with tumors). (Lower) Tumor multiplicity (no. of tumors/no. of rats at risk). ... with respect to tumor multiplicity (tumors per animal), and incidence (fraction of tumor-bearing animals) (Fig. 5). The tumor ... Inhibition of Mammary Tumor Development in Rats.. Mammary tumors were produced in female Sprague-Dawley rats by feeding single ...
The plant that we are going to talk about today is the mulberry herb. It originates from China but it can be found all across ... This Plant Is Everywhere, But You Had No Idea It Can Treat Tumors, Diabetes And High Blood Pressure!. ... The plant that we are going to talk about today is the mulberry herb. It originates from China but it can be found all across ... I AM 60 YEARS OLD AND THIS PLANT RETURNED MY VISION, REMOVED FAT FROM MY LIVER AND COMPLETELY CLEANED MY COLON ...
  • Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants. (nih.gov)
  • Here, we address the biological role of Arabidopsis translationally controlled tumor protein (AtTCTP) and test its shared functions in animals and plants. (nih.gov)
  • A cDNA encoding a homolog of human translationally controlled tumor protein (TCTP) was isolated from cotyledons of the short-day plant Pharbitis nil cv. (oup.com)
  • In this study, we functionally characterized a rice translationally controlled tumor protein gene (Os11g43900, OsTCTP ) involved in Hg stress tolerance. (biomedcentral.com)
  • Translationally controlled tumor protein (TCTP) is a highly conserved protein found in eukaryotes, across animal and plant kingdoms and even in yeast. (wikipedia.org)
  • Translationally Controlled Tumor Protein (TCTP/tpt1) is a regulator of the cancer stem cell compartment, the tumor reversion program, tumor progression and certain forms of inflammatory diseases.Susini L et al. (wikipedia.org)
  • Translationally Controlled Tumor Protein (TCTP) is a protein that in humans is encoded by the TPT1 gene. (wikipedia.org)
  • Human translationally controlled tumor protein (hTCTP) is a growth-related, calcium-binding protein. (wikipedia.org)
  • Translationally controlled tumor protein was first discovered in 1989 as a cDNA sequence obtained from a human mammary carcinoma cDNA library with proves derived from the translationally controlled, growth-related mouse tumor protein TCTP. (wikipedia.org)
  • Translationally-controlled tumor protein has a role in tumor reversion and development. (wikipedia.org)
  • Translationally Controlled Tumor Protein (TCTP) is involved in a wide range of molecular interactions with biological and nonbiological partners of various chemical compositions such as proteins, peptides, nucleic acids, carbohydrates, or small molecules. (wikipedia.org)
  • Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice. (nih.gov)
  • Here, we present a detailed analysis of PVX biodistribution and clearance in healthy mice and mouse tumor xenograft models using a combination of ex vivo whole-organ imaging, quantitative fluorescence assays and immunofluorescence microscopy. (nih.gov)
  • After silibinin treatment, tumour cells resumed normal ACTH production, tumour growth slowed down and symptoms of Cushing Disease disappeared in mice. (daily-sun.com)
  • Triple-negative breast cancer tumors of mice treated with the phenanthriplatin -carrying nanoparticles were four times smaller than those treated either with cisplatin, a common and related chemotherapy drug, or free phenanthriplatin injected intravenously into circulation. (teknoscienze.com)
  • In vivo anti-tumor activity was evaluated in nude mice bearing subcutaneously human Ando-2 melanoma cells. (biomedcentral.com)
  • The intraperitoneal injection or oral administration of LACE extract in nude mice inhibits in vivo tumor growth of Ando-2 melanoma cells and prolongs the survival day of the mice. (biomedcentral.com)
  • The LACE extract presented in vivo anti-tumoral activity in nude mice against tumor growth of Ando-2 melanoma cells. (biomedcentral.com)
  • Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice. (mysciencework.com)
  • Scientists from Case Western Reserve University School of Medicine as teams with analysts from Dartmouth Geisel School of Medicine and RWTH Aachen University (Germany) have adjusted infection particles - that regularly taint potatoes - to fill in as tumor tranquilize conveyance gadgets for mice. (health11.com)
  • What's more, at the same time infusing the nanoscale plant infection particles and chemotherapy sedate - doxorubicin - into tumor destinations additionally helps stop tumor movement in mice. (health11.com)
  • The results are the first to indicate "inoculating" mice with potato infection nanoparticles at a growth site can create a hostile to tumor reaction. (health11.com)
  • Consumption of the inulin gel expanded and increased the number of beneficial microbes in tumor-bearing mice," said Kai Han, postdoctoral fellow and first author of the study. (amazinghealthadvances.net)
  • Silencing of HoxA1 with nanoparticle siRNA prevented loss of hormone receptor expression, suppressed cell proliferation, and reduced mammary tumor incidence in mice. (sciencemag.org)
  • When transplanted into mice, tumor genomes evolve differently than they do in patients, study finds. (the-scientist.com)
  • An HCC model was established in H22 tumor-bearing mice and triterpenoid saponins were administered at various doses. (dovepress.com)
  • Human tumors transplanted into laboratory mice disappeared or shrank when scientists treated the animals with a single antibody, according to a new study from the Stanford University School of Medicine. (medicalxpress.com)
  • Berger DP, Winterhalter BR and Fiebig HH (1992) Establishment and characterization of human tumor xenografts in thymus aplastic nude mice. (nature.com)
  • In a study reported in the team's Cancer Research paper, tumors in mice that received an intravenous injection of nanorods plus near-infrared laser treatment disappeared within 15 days. (phys.org)
  • It also inhibited the growth of S-180 tumor to 49% of the control at the dose of 200 mg kg(-1) d(-1) and extended the survival time of the tumor-bearing mice. (nih.gov)
  • C57BL/6 mice immunized with E7-containing crude foliar extracts developed both humoral and cell-mediated immune responses and were protected from tumor development after challenge with the E7-expressing C3 tumoral cell line. (elsevier.com)
  • No AtTCTP protein accumulation is observed in tctp -1 and tctp -2 plants. (nih.gov)
  • In their experiments the researchers found tremendously high amounts of the heat shock protein 90 (HSP90) in tumour tissue from patients with Cushing Disease. (daily-sun.com)
  • Here we show that moderate activation of the pathway conferred either by mutation in the Gα subunit or by mutation in the regulatory subunit of the protein kinase A influences tumor morphology. (apsnet.org)
  • Human isoforms of the p53 protein play a key role in maintaining genetic stability, functioning as active tumour suppressors. (europeanpharmaceuticalreview.com)
  • The main effect of this binding is that, firstly, the protein loses its function 1 and, secondly, it becomes an oncoprotein that promotes tumour formation and metastasis 3 . (europeanpharmaceuticalreview.com)
  • These studies suggest that protein Tyr (de)phosphorylation performs critical functions in plants. (plantcell.org)
  • L1 protein was detected in concentrated plant extracts at concentrations up to 1.0 mg/kg in transgenic plants and up to 0.4 mg/kg in TMV-infected plants. (asm.org)
  • by generating a fusion protein of CCL4 and the collagen-binding domain (CBD) of von Willebrand factor, we show that CBD fusion enhances CCL4 tumor localization. (sciencemag.org)
  • The translationally controlled tumour protein, commonly known as TCTP, is a highly conserved protein among many eukaryotic organisms. (wikipedia.org)
  • The Mammalian translationally controlled tumour protein (TCTP) (or P23) is a protein which has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. (wikipedia.org)
  • TCTP was originally described as a growth related protein of tumor cells. (wikipedia.org)
  • Research in 1997 shown that TCTP is not a tumor- or tissue-specific protein, but is expressed ubiquitously from plants to mammals. (wikipedia.org)
  • Expression levels of TCTP were down-regulated at the mRNA and protein levels during tumor suppression and by the activation of p53 and Siah-1 very well known anti-tumor genes. (wikipedia.org)
  • While damaging healthy cells is an inevitable process through most cytotoxic drugs, chemotherapy also triggers them to secrete a protein that sustains tumour growth and resistance to further treatment. (healthyaeon.com)
  • p53 protein functions as a sequence-specific transcription factor and its tumor suppressor function is attributed to its ability to regulate gene expression. (biologists.org)
  • Heat shock protein 70 is an antiapoptotic chaperone protein highly expressed in human breast tumors and tumor cell lines. (pnas.org)
  • Despite the apoptotic morphology as judged by electron microscopy, the asHsp70-induced death was independent of known caspases and the p53 tumor suppressor protein. (pnas.org)
  • In this study, we describe for the first time the expression of the human papillomavirus 16 E7 protein in Nicotiana benthamiana plant using a potato virus X-derived vector. (elsevier.com)
  • The anti-tumor activity of HTCP in the mouse tumor model was not correlated with immunomodulation and galectin-3 inhibition, but correlated well with proliferation inhibition. (nih.gov)
  • These results show that molecular analyses of patient samples can add to the information about the tumor and help us in tracking back the progression of the disease," the authors concluded. (medindia.net)
  • The ability of tumors to evade being recognized by the immune system plays a critical role in cancer progression. (genengnews.com)
  • Using mouse models of breast cancer and melanoma, they show that loss of the Type III TGF-β receptor (TGFBR3) in tumors promotes cancer progression by altering signaling in tumor-associated immune cells. (genengnews.com)
  • Impaired apoptosis signaling is common in cancer cells and may play an important role in tumor initiation and progression ( 1 - 4 ). (pnas.org)
  • It has been recognized all over the world and plant polysaccharides have anti-tumor effect through their immunomodulating effect on the organisms which carried tumor. (cnki.com.cn)
  • In this study, we evaluated the in vitro cytotoxic anti-tumor and immunomodulatory activities and in vivo anti-tumor effect of Laser Activated Calendula Extract (LACE), a novel extract of the plant Calendula Officinalis (Asteraceae) . (biomedcentral.com)
  • MCP had no anti-proliferative effects on these cancer cells and no anti-tumor effect in the mouse model. (nih.gov)
  • Furthermore, the N-terminal domain of TCTP inhibits apoptosis by binding to apoptotic factors and by inhibiting p53 tumour suppressor-dependent apoptosis by downregulating it. (wikipedia.org)
  • Furthermore, Bcl-2 and Bcl-X L , which protect tumor cells from most forms of apoptosis, failed to rescue breast cancer cells from asHsp70-induced death. (pnas.org)
  • Resistance of cancer cells to apoptosis is especially deleterious because it not only enhances the spontaneous growth of tumors but also renders them resistant to host defense mechanisms as well as various forms of therapy. (pnas.org)
  • Interestingly, Hsp70 rescues cells from apoptosis induced by, e.g., tumor necrosis factor (TNF), without inhibiting the activation of effector caspases ( 19 ). (pnas.org)
  • In addition to its preferential expression in tumors and its ability to inhibit apoptosis, the role of Hsp70 in tumorigenesis is supported by data showing that its expression enhances the tumorigenic potential of rodent cells in vivo ( 20 - 22 ). (pnas.org)
  • Earlier results of a preliminary nature have suggested that the inhibition of Hsp70 synthesis in tumor cells may either sensitize them to chemotherapy or commit them to apoptosis ( 19 , 27 , 28 ). (pnas.org)
  • In addition, triterpenoid saponins inhibited tumor growth and induced the apoptosis of HCC cells by blocking the activation of PD1/PD-L1, ERK1/2, p38 MAPK, JNK, and STAT3 signaling pathways. (dovepress.com)
  • Studies have show that ursolic acid suppresses tumor formation, inhibits tumor growth, induces apoptosis, inhibits angiogenesis, inhibits signaling and activation pathways, induces tumor cell differentiation, and suppresses growth factor expression. (essense-of-life.com)
  • When chronically applied to the skin, they supposedly would not damage normal skin cells or negatively affect their functions while they would suppress tumorigenic cell transformation, inhibit tumor cell proliferation, and activate tumor cell apoptosis. (elsevier.com)
  • A localized proliferation of plant tissue forming a swelling or outgrowth, commonly with a characteristic shape and unlike any organ of the normal plant. (harvard.edu)
  • Consistent with this finding, plant AtTCTP can fully rescue cell proliferation defects in Drosophila loss of function for dTCTP. (nih.gov)
  • These results indicate that some inhibitors of plant cell division are capable of inhibiting the proliferation of animal tumor cells. (aacrjournals.org)
  • Tumor cell lines derived from leukemias, melanomas, fibrosarcomas and cancers of breast, prostate, cervix, lung, pancreas and colorectal were used and tumor cell proliferation in vitro was measured by BrdU incorporation and viable cell count. (biomedcentral.com)
  • The LACE extract showed a potent in vitro inhibition of tumor cell proliferation when tested on a wide variety of human and murine tumor cell lines. (biomedcentral.com)
  • Ursolic acid demonstrated a significant inhibition of the proliferation of cultured tumour cells. (essense-of-life.com)
  • While up to 30% of the PVX signal was from the colon, mammary and brain tumor tissues, remaining particles were cleared by the reticuloendothelial system organs (the spleen and liver), followed by slower processing and clearance through the kidneys and bile. (nih.gov)
  • Cell walls from normal and tumor tissues in culture also show this difference, indicating that the two types of tissue stably maintain this difference under these conditions. (sciencemag.org)
  • Crown-gall tumors thus resemble embryonic tissues in this respect. (sciencemag.org)
  • We assumed that in these tissues, the genes involved in plant differentiation could be induced or repressed, and thus current project is directed to isolation and characterization of such genes. (nii.ac.jp)
  • Sulforaphane induces several phase 2 enzymes in both cultured cells and mouse tissues ( 15 ), blocks 7,12-dimethylbenz( a )anthracene (DMBA)-initiated mammary tumor formation in rats ( 16 ), and inhibits neoplastic nodule formation in cultured mouse mammary glands ( 17 ). (pnas.org)
  • OsTCTP was ubiquitously expressed in all examined plant tissues, especially in actively dividing and differentiating tissues, such as roots and nodes. (biomedcentral.com)
  • Immunofluorescence, flow cytometry, and western blot were performed to analyze the effect of triterpenoid saponins on immune response in tumor tissues. (dovepress.com)
  • Metabolomic analysis was carried out to assess the metabolites involved in mediating the effect of triterpenoid saponins on tumor tissues. (dovepress.com)
  • However, it's difficult to heat patients' tumors without damaging nearby tissues. (phys.org)
  • Another advantage of the nanorods is that by coating them with different types of light-scattering molecules, they can be designed to simultaneously gather multiple types of information - not only whether there is a tumor, but whether it is at risk of invading other tissues, whether it's a primary or secondary tumor, or where it originated. (phys.org)
  • The p53 gene is one of the most intensively studied tumour suppressor genes. (europeanpharmaceuticalreview.com)
  • Here, we describe the functional analysis of an Arabidopsis gene ( AtPTEN1 ) that encodes a Tyr phosphatase closely related to PTEN, a tumor suppressor in animals. (plantcell.org)
  • Cushing Disease is caused by a tumour in the pituitary gland in the brain. (daily-sun.com)
  • Alpine skier Hailey Duke is paying her own expenses to pursue a spot on the U.S. Olympic team following surgery to remove a benign tumor from her pituitary gland. (thestar.com)
  • Brain surgery was looming to remove a tumour that was attached to her pituitary gland. (thestar.com)
  • Through a routine blood test last fall, doctors found increased levels of prolactin in her system, indicating the possible presence of a tumour on her pituitary gland. (thestar.com)
  • A ) Homozygous tctp -1 and tctp -2 embryos rescued by nutrient supplements in vitro develop into adult plants. (nih.gov)
  • In this review, the in vitro and in vivo effects of two medicinal, phytochemical-producing plants that were obtained from Adekunle Ajasin University's botanical garden are discussed. (europeanpharmaceuticalreview.com)
  • An aqueous extract of Calendula Officinalis was obtained by a novel extraction method in order to measure its anti-tumor and immunomodulatory activities in vitro . (biomedcentral.com)
  • These results indicate that LACE aqueous extract has two complementary activities in vitro with potential anti-tumor therapeutic effect: cytotoxic tumor cell activity and lymphocyte activation. (biomedcentral.com)
  • The aim of the present study was to evaluate the in vitro cytotoxic anti-tumor and immunomodulatory activities of a novel extract of the plant Calendula Officinalis (LACE: Laser Activated Calendula Extract). (biomedcentral.com)
  • Arabidopsis plants grown in vitro in CRAG's growth chambers. (cragenomica.es)
  • The fourth part, containing investigative information on almost 300 individual plant species with established anticancer properties, either on a clinical or in vitro level, is with no doubt the most analytical. (routledge.com)
  • The altered glycosylation of MUC1 reveals an immunodominant peptide along its tandem repeat (TR) that has been used as a target for tumour immunotherapy. (mysciencework.com)
  • Intravenous CBD-CCL4 administration recruits CD103 + DCs and CD8 + T cells and improves the antitumor effect of CPI immunotherapy in multiple tumor models, including poor responders to CPI. (sciencemag.org)
  • The researchers concluded that if TGF-β expression is inhibited, this would provide a novel method of tumor immunotherapy and that "sTGFBR3 levels could serve as a predictive immunotherapy biomarker. (genengnews.com)
  • The most promising way to exploit plant RIPs as weapons against cancer cells is either by designing molecules in which the toxic domains are linked to selective tumor targeting domains or directly delivered as suicide genes for cancer gene therapy. (mdpi.com)
  • Tumour suppression gene products are produced by cells to monitor the efficiency of the cell cycle by populating specific phases in the process of both DNA and cell replications 1 . (europeanpharmaceuticalreview.com)
  • RNA gel blot analysis and examination of promoter-reporter constructs in transgenic Arabidopsis plants revealed that the AtPTEN1 gene is expressed exclusively in pollen grains during the late stage of development. (plantcell.org)
  • We first generated shoot-forming and unorganized calli in tobacco plants upon introduction of auxin and cytokinin biosynthesis genes, and 6b gene which modulates the effects of these plant growth substances. (nii.ac.jp)
  • Finally, the psaB and ribonucleoprotein gene seem to be required for chloroplast development, and further investigation is necessary to determine the relationship between plastid and total plant development. (nii.ac.jp)
  • Analysis of his tumors following surgeries, biopsies and autopsy revealed several genetic aberrations, including multiple copies of a region on chromosome 4q, which includes the KIT gene. (medindia.net)
  • Additional findings included the loss of the gene PKP4, which is associated with increased tumor size. (medindia.net)
  • Join this webinar to learn how spatial resolution of gene expression in tumor tissue reveals new insights in biomarker discovery and therapeutic response. (genomeweb.com)
  • A new study has shown that survival rates among patients with glioma double if the tumor carries a methylated MGMT gene. (news-medical.net)
  • Moreover, in lower plants it is phytochrome that steers growth direction - that simply can't be done via gene regulation. (innovations-report.com)
  • Bayer's new Vitrakvi for tumors with NTRK gene fusions is meeting skepticism in England and Germany, where cost watchdogs on Friday rejected it. (fiercepharma.com)
  • 1983), "A chimaeric antibiotic resistance gene as a selectable marker for plant cell transformation," Nature 304:184-187. (freepatentsonline.com)
  • 1983) "Multiple Viral Specific Transcripts from the Genome of Cauliflower Mosaic Virus," Proceedings of the Miami Winter Symposium, Jan. 1983, published in Advances in Gene Technology: Molecular Genetics of Plants and Animals (Ahmad et al. (freepatentsonline.com)
  • 1983) "Ti and Ri Plasmids as Vectors for Genetic Engineering of Higher Plants," Proceedings of the Miami Winter Symposium, Jan. 1983, published in Advances in Gene Technology: Molecular Genetics of Plants and Animals (Ahmad et al. (freepatentsonline.com)
  • NEWS, 26 March 2010] Gene therapy on a tomato gene could be of value in future treatment of brain tumors, according to a new study from Karolinska Institutet and Lund University. (ki.se)
  • Glucosinolates and isothiocyanates can be efficiently extracted from plants, without hydrolysis of glucosinolates by myrosinase, by homogenization in a mixture of equal volumes of dimethyl sulfoxide, dimethylformamide, and acetonitrile at −50°C. Extracts of 3-day-old broccoli sprouts (containing either glucoraphanin or sulforaphane as the principal enzyme inducer) were highly effective in reducing the incidence, multiplicity, and rate of development of mammary tumors in dimethylbenz( a )anthracene-treated rats. (pnas.org)
  • TCTP knockdown in primary mammary tumor cells, results in increased p53 expression and a decreased number of stem-like cancer cells. (wikipedia.org)
  • A massive abdominal tumor measuring about 10 kg has been removed from a female patient, by surgeons in the western Croatian town of Gospic. (medindia.net)
  • We show that, in contrast to animal TCTP, plant AtTCTP is not implicated in regulating postmitotic growth. (nih.gov)
  • Our data provide evidence that TCTP function in regulating cell division is part of a conserved growth regulatory pathway shared between plants and animals. (nih.gov)
  • A ) Siliques produced by WT or by heterozygous AtTCTP/tctp -1 and AtTCTP/tctp -2 plants. (nih.gov)
  • B ) Semiquantitative RT-PCR analysis showing no expression of AtTCTP in leaves of both tctp -1 and tctp -2 plants. (nih.gov)
  • C ) Western blot analysis of AtTCTP accumulation in leaves of WT, tctp -1, and tctp -2 plants using anti-AtTCTP antibody. (nih.gov)
  • Down-regulation of TCTP can induce tumor reversion, and in combination with some drugs that decrease the level of TCTP and will lead to kill tumor cells. (wikipedia.org)
  • Nanoparticles based on plant viruses are emerging biomaterials for medical applications such as drug delivery and imaging. (nih.gov)
  • The long, thin tobacco mosaic virus nanoparticles are naturals for delivering the drug candidate into tumors, said Steinmetz, who was appointed by the Case Western Reserve School of Medicine. (teknoscienze.com)
  • Inside tumors, the nanoparticles gather inside the lysosomal compartments of cancer cells, where they are, in essence, digested. (teknoscienze.com)
  • The projects, which aim to grow plants without soil, teach computers to check mathematical proofs, and use nanoparticles for cancer detection, will each receive £250,000 for three years. (imperial.ac.uk)
  • NEW YORK (GenomeWeb News) - Researchers from the US and Canada reported online in Nature yesterday that they have successfully used single-cell sequencing to discern copy number patterns in individual cells from primary and metastatic breast tumors. (genomeweb.com)
  • CV extracts showed antiprolife-rative and proapoptotic effects in all MTC and SI-NET cell lines, whereby high growth inhibition was observed by treatment with the ethylacetate-extracts (CV-45) in tumor cell lines but not in normal human fibroblasts. (spandidos-publications.com)
  • Marko D, Schätzle S, Friedel A, Genzlinger A, Zankl H, Meijer L and Eisenbrand G (2001) Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells. (nature.com)
  • The analysts found infusing potato infection particles into melanoma tumor locales actuates a hostile to tumor invulnerable framework reaction. (health11.com)
  • At the point when the plant-based infection particles and the medications could take a shot at their own, we saw the best benefit. (health11.com)
  • Steinmetz and her group will next research instruments behind the potato infection particles' hostile to tumor impacts. (health11.com)
  • Now, MIT researchers have developed tiny gold particles that can home in on tumors, and then, by absorbing energy from near-infrared light and emitting it as heat, destroy tumors with minimal side effects. (phys.org)
  • This class of particles provides the most efficient method of specifically depositing energy in tumors," he said. (phys.org)
  • In designing the particles, the researchers took advantage of the fact that blood vessels located near tumors have tiny pores just large enough for the nanorods to enter. (phys.org)
  • This article aims at reviewing the current advances in p53 research, as well as discussing the possibilities of inhibiting the expression and activity of mutant p53 genes in human malignancies through the use of medicinal plants. (europeanpharmaceuticalreview.com)
  • By analysing the expression of cell cycle genes in the Arabidopsis leaves, the researchers discovered that several of these genes had altered oscillations in plants with high accumulation of TOC1. (cragenomica.es)
  • Not surprisingly, it has been found that very many plant genes are regulated by phytochrome, and indeed most textbooks say that phytochrome works exclusively in this manner. (innovations-report.com)
  • This invention relates to chimeric genes which are capable of being expressed in plant cells. (freepatentsonline.com)
  • Neuroendocrine tumors respond poorly to radiation and conventional chemotherapy, hence surgical removal of the neoplastic tissue is still the most effective way of treatment. (spandidos-publications.com)
  • The patient in the study received conventional treatment, which included surgical removal of his tumors, radiation therapy and chemotherapy, and participation in a clinical trial. (medindia.net)
  • 4. Anti-tumor and anti radiation, inhibit tumor growth,prevent postoperative recurrence,reduce side-effects during chemotherapy or radiotherapy, such as mitigate the pains,suppress hair loss, etc. (plantbased-powder.com)
  • Most of those patients are treated with chemotherapy and/or radiation, which are often effective but can have debilitating side effects because it's difficult to target tumor tissue. (phys.org)
  • With chemotherapy treatment, 99 percent of drugs administered typically don't reach the tumor, said von Maltzahn. (phys.org)
  • Additionally, heating them to a lower temperature weakens tumor cells enough to enhance the effectiveness of existing chemotherapy treatments, raising the possibility of using the nanorods as a supplement to those treatments. (phys.org)
  • The Gynecologic Oncology Group (GOG) is currently conducting a randomized phase II trial (Clinical trial ID: NCT104522) comparing BEP with carboplatin and paclitaxel for patients with advanced or recurrent chemotherapy-naive sex cord stromal tumors. (medscape.com)
  • The second part is a brief journey in pharmacognosy, with detailed information about each of the fourteen different chemical groups of plant secondary metabolites, their use in cancer chemotherapy, and updated information on the biotechnological production of the most representative compounds in clinical practice. (routledge.com)
  • Scientists around Gunter Stalla, endocrinologist at the Max Planck Institute of Psychiatry in Munich, have discovered in cell cultures, animal models and human tumour tissue that a harmless plant extract can be applied to treat Cushing Disease. (daily-sun.com)
  • As there are too many HSP90 molecules in the tumour tissue, they stick to the glucocorticoid receptor," said Paez-Pereda. (daily-sun.com)
  • Habituated tissue cultures, which resemble crown-gall tumor cultures, however, form cell walls that are inhibitory like those of the normal cultures from which they are derived. (sciencemag.org)
  • A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. (innovations-report.com)
  • Any tissue that lights up, other than the liver or spleen, could harbor an invasive tumor. (phys.org)
  • Ricin, the plant RIP prototype that comprises a catalytic A subunit linked to a galactose-binding lectin B subunit to allow cell surface binding and toxin entry in most mammalian cells, shows a potency in the picomolar range. (mdpi.com)
  • Neuroendocrine tumors (NETs) represent rare tumors that are derived from cells of the embryonic neural crest. (spandidos-publications.com)
  • MTCs are calcitonin producing tumors arising from the parafollicular C-cells and occur in ~4-10% of all thyroid tumors ( 2 ). (spandidos-publications.com)
  • In a previous study, pheophorbid-a, a chlorophyll derivative in Christia vespertilionis plant extracts showed high antiproliferative activity in MTC cells ( 13 ). (spandidos-publications.com)
  • Although it is well known that Tyr phosphatases play a critical role in signal transduction in animal cells, little is understood of the functional significance of Tyr phosphatases in higher plants. (plantcell.org)
  • Although both Ser/Thr and Tyr phosphorylation play a crucial role in cellular regulation in animal systems, only Ser/Thr phosphorylation has been established as an important regulatory mechanism in plant cells. (plantcell.org)
  • The normal immunity system can identify and kill tumor cells, however, the occurrence rate of tumor will enhance if it lacks of the ability of immunologic defence or immunological recognition. (cnki.com.cn)
  • The elongated shape of the nanoparticle causes it to tumble along the margins of blood vessels, remain unnoticed by immune cells and pass through the leaky vasculature of tumors and accumulate inside. (teknoscienze.com)
  • Although anti-PD-1 antibodies initially bound to T cells as intended, the authors found that tumor-associated macrophages quickly removed these antibodies from T cells, thus inactivating them. (sciencemag.org)
  • Myrosinase (see ref. 18 ) is normally segregated from glucosinolates and is released when plant cells are injured. (pnas.org)
  • When we counted the number of cells in the leaves of the plants that overexpress TOC1, we saw that there were fewer cells, which suggested that by modifying the circadian clock, we were also modifying the cell division pace ", explains Jorge Fung, pre-doctoral student and first author of the work. (cragenomica.es)
  • The cells of the plants that overexpress TOC1 remain longer at the G1 phase, failing to enter the S phase at the appropriate time " says Jorge Fung. (cragenomica.es)
  • The composition of tumor-infiltrating immune cells has been identified as a key factor influencing CPI therapy success. (sciencemag.org)
  • A lack of the chemokine CCL4 within the tumor microenvironment leads to the absence of CD103 + dendritic cells (DCs), a crucial cell population influencing CPI responsiveness. (sciencemag.org)
  • The scientists say their study also supports the use of TGF-β inhibitors to enhance the efficacy of therapies that promote immune-mediated elimination of tumor cells. (genengnews.com)
  • Work with the murine models demonstrated that the loss of tumor-expressed TGFBR3/sTGFBR3 enhanced TGF-β signaling within locoregional dendritic cells (DC). (genengnews.com)
  • SAN FRANCISCO (GenomeWeb) - Tumor sequencing tests may pick up not only somatic mutations found in the tumor but also a certain class of non-cancerous mutations that accumulate in hematopoietic stem cells and are associated with age, according to a recent study published by researchers from Rutgers University and Foundation Medicine. (genomeweb.com)
  • Brucea javanica (Brucea javanica (L.) Merr) is one of those plants that needs far more recognition in this catergory for its incredible ability to selectively kill cancer cells. (healthyaeon.com)
  • Hsp70 is abundantly expressed in malignant human tumors of various origins, whereas in normal cells, its expression is mainly stress inducible. (pnas.org)
  • Triterpenoid saponins induced anti-tumor immune response by decreasing the number of Treg cells, increasing that of B cells, natural killer cells, and CD3 + /CD28 + T cells, and reducing the secretion of inflammatory factors including nuclear factor-κB, cyclooxygenase-2, and microsomal prostaglandin E synthase-1. (dovepress.com)
  • The treatment of cancer with chemotherapeutic agents and radiation has two major problems: tumor resistance to therapy and toxicity toward normal cells. (essense-of-life.com)
  • Recent research has suggested that plant polyphenols (which includes ursolic acid) might be used to sensitize tumor cells to chemotherapeutic agents and radiation therapy by inhibiting pathways that lead to treatment resistance. (essense-of-life.com)
  • PhysOrg.com) -- It has long been known that heat is an effective weapon against tumor cells. (phys.org)
  • During a single exposure to a near-infrared laser, the nanorods heat up to 70 degree Celsius, hot enough to kill tumor cells. (phys.org)
  • The nanorods could also be used to kill tumor cells left behind after surgery. (phys.org)
  • 1977) "T-DNA from Agrobacterium Ti plasmid is in the nuclear DNA fraction of crown gall tumor cells," Proc. (freepatentsonline.com)
  • 1982) "Agrobacterium rhizogenes inserts T-DNA into the genomes of the host plant root cells," Nature 295:432-434. (freepatentsonline.com)
  • The reproductive success of seed plants is performed and based on the invention of the pollen tube, an extension of the pollen grain that is produced under favorable conditions and that allows the sperm cells to move from the male gametophyte towards the female one. (mdpi.com)
  • From a pure biological point of view, the pollen tube is an atypical plant cell, because it grows by a tip-growing mechanism, rather than by the typical diffuse way of somatic cells. (mdpi.com)
  • The data support a role of plant AtTCTP as a positive regulator of mitotic growth by specifically controlling the duration of the cell cycle. (nih.gov)
  • The study also suggests that, although the cell division machinery is shared in all multicellular organisms to control growth, cell expansion can be uncoupled from cell division in plants but not in animals. (nih.gov)
  • Instead of the roots aligning their growth to gravity, the team also plan to make use of electrotropism - where plant roots align with external electric fields. (imperial.ac.uk)
  • Now, a research team from the Centre for Research in Agricultural Genomics (CRAG), led by the CSIC researcher Paloma Mas, has shown, for the first time in plants, that the circadian clock controls the speed of the cell cycle and, consequently, regulates the cell division and growth in synchronization with the day and night cycles. (cragenomica.es)
  • Reishi mushroom can also lower cholesterol, prevent blood clots, help prevent the growth of tumors, and increase the body's ability to fight unwanted invaders. (plantbased-powder.com)
  • Mercury (Hg) is not only a threat to public health but also a growth risk factor to plants, as it is readily accumulated by higher plants. (biomedcentral.com)
  • Plants have provided a new avenue in curbing tumor growth. (news-medical.net)
  • Schmidt have exhibited anti-cancer properties and exerted remarkable inhibitory effects on tumor growth. (dovepress.com)
  • Generally, plants adjust their growth to fit in with their local environment, light being easily the most important factor - after all, they need light to live. (innovations-report.com)
  • Whereas phototropin somehow steers growth direction in higher plants, phytochrome controls most aspects of plant development including germination, stem extension, greening and even flowering. (innovations-report.com)
  • Though population growth and rising demand for resources as more of the world enters into consumeristic lifestyles both play a part in the rising amount of plant life consumed, as this chart shows, on a global basis rising per capita increases in consumption have far outpaced the influence of population growth. (treehugger.com)
  • Topical application of ursolic acid inhibited TPA-induced initiation and promotion of tumor growth. (essense-of-life.com)
  • This study suggests for the first time the ability of S. perfoliata, S. thymbra, S. officinalis, L. nobilis and P. palestina essential oils and some identified terpenes to inhibit human tumor cell growth. (nih.gov)
  • A gardener explains that growing lavender plants requires planting them in good compost or potting soil, putting them in a place with full, hot sun and trimming them back in the fall for a lush growth the following spring. (nottingham.ac.uk)
  • A phlorogrucinol-monoterpene derivative, euglobal-G1, obtained from leaves of E. grandis exhibited a remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[ α ]anthracene [ 6 ]. (hindawi.com)
  • As the incidence of skin tumors has been steadily growing, there is an urgent need for the preventive measures as well as the improved therapeutic approaches. (elsevier.com)
  • The major aim of this critical review is to provide recent updates on the molecular and cellular targets for the prevention and therapy of skin tumors with a special focus on the crossroad between inflammation and carcinogenesis as the most promising approach to chemoprevention. (elsevier.com)
  • The feasibility of PPs to prevent/ cure specific cutaneous toxicity connected to anti-EGFR therapy and to reduce multidrug resistance of skin tumors is also discussed. (elsevier.com)
  • Testicular germ cell cancer, a disease that is rare but growing in incidence in men in the United States, is considered to be among the most curable of solid tumors. (news-medical.net)
  • Scientists at the Genome Institute of Singapore (GIS) have unraveled the mechanism that causes liver cancer (hepatocellular carcinoma, HCC), one of the most common solid tumors worldwide. (medicalxpress.com)
  • Thus, enhancing tumor immune cell infiltration is a critical challenge. (sciencemag.org)
  • In a pair of firsts, researchers at Case Western Reserve University and Massachusetts Institute of Technology have shown that the drug candidate phenanthriplatin can be more effective than an approved drug in vivo, and that a plant-virus-based carrier successfully delivers a drug in vivo. (teknoscienze.com)
  • The researchers say delivery of the phenanthriplatin into the tumor led to its improved performance over cisplatin or free phenanthriplatin. (teknoscienze.com)
  • Researchers at Translational Genomics Research Institute (TGen) and Scottsdale Healthcare said that studying how tumors evolve can help the development of new treatments which can prevent the cancer from recurring. (medindia.net)
  • TGen researchers tracked several years of tumor evolution in a 47-year-old male patient with maxillary sinus carcinoma (MSC), a rare cancer of the sinus cavities beneath the cheeks that often requires surgical removal that is disfiguring. (medindia.net)
  • To reveal how the circadian clock controls the cell cycle, the researchers analysed the duration of each cell cycle phase in the leaves of plants that overexpress TOC1 and compared it with control plants. (cragenomica.es)
  • This increase stems from higher plant colonization rates and lower extinction rates in connected versus unconnected fragments, researchers report in the Sept. 27 Science . (sciencenews.org)
  • Every tumor is different, which is why Bayer researchers are working on new, personalized forms of treatment which will use small molecules to target the causes of cancer. (wczasy-egipt.com)
  • For instance, when inulin gel was combined with an immune checkpoint inhibitor in a colon carcinoma rodent model, the rate of tumor eradication doubled (100% improvement), compared with the immune checkpoint inhibitor therapy alone. (amazinghealthadvances.net)
  • In the last two decades, natural plant derived polyphenols (PPs, resveratrol, silibinin, green tea polyphenols, flavonoids, anthocyanins, etc.) have been drawing particular interest as emerging active substances in dermatological/ cosmeceutical compositions for the prevention, slowing, or reversion of skin tumorigenesis (chemoprevention). (elsevier.com)
  • The results indicate that Christia vespertilionis could serve as an anticancer therapeutic for treatment of neuroendocrine tumors. (spandidos-publications.com)
  • Roth T, Burger AM, Dengler W, Willmann H and Fiebig HH (1999) Human tumor cell lines demonstrating the characteristics of patient tumors as useful models for anticancer drug screening. (nature.com)
  • Our data support the possibility of producing a cost-effective anticancer vaccine in plant with intrinsic adjuvant-like properties. (elsevier.com)
  • Tumors can be benign (unlikely to spread to other body parts) or malignant (likely to spread). (thefreedictionary.com)
  • 5/18/2015, Fukushima prefectural government announced they found malignant or possible malignant thyroid tumor from 127 children so far. (fukushima-diary.com)
  • In the following paragraphs we explore how the specific phytochemicals from medicinal plants can be used in either preventing the formation of mutant p53, or shutting down the activities of mutant p53 in the metastasis of malignancies. (europeanpharmaceuticalreview.com)
  • Beyond limited empirical observations, not all medicinal plants have established scientific studies to support their effectiveness. (healthyaeon.com)
  • The effectiveness of medicinal plants and foods to treat cancer is perhaps receiving the most widespread attention. (healthyaeon.com)
  • The results demonstrate the cytotoxic potential of the B. albiflora hexanic fraction and substantiate the importance of the study of the traditional Mayan medicinal plants. (hindawi.com)
  • Together with what was previously described, the traditional medicine of the indigenous pueblos was recognized by the World Health Organization (WHO), which caused a powerful drive toward the research of medicinal plants [ 1 ]. (hindawi.com)
  • 147. Antineoplastic alkaloids from Chinese medicinal plants and their analogs. (nature.com)
  • Ursolic acid is a compound that exists widely in food, medicinal herbs and other plants. (essense-of-life.com)
  • Medicinal aromatic plants belong to a big plant group with a great interest due to its pharmaceutical, cosmetic and nutritional application. (nottingham.ac.uk)
  • Bolivia-Kallawayan medicinal plants as leads to anti-HIV, anti-tumor and other potential drugs / by Qi Jia. (tcu.edu)
  • Modulation of distinct signaling elements can generate plants with improved stress resistance. (oup.com)
  • The condition was clinically diagnosed as a right-sided benign tumor of the vastus lateralis muscle. (who.int)
  • The Occlusin 500 Artificial Embolization Device (OCL 500) is a microspherical embolization agent approved for the treatment of highly vascularized, unresectable tumors, e.g., hepatocellular carcinoma or renal cell carcinoma. (medgadget.com)
  • In an attempt to find new therapeutic plant extracts of Christia vespertilionis (CV) their antitumor potential in human medullary thyroid carcinoma (MTC) and human small intestinal neuroendocrine tumor (SI-NET) cell lines were tested. (spandidos-publications.com)
  • Remarkably, isoquinoline alkaloids, usually typical for Papaveraceae or closely related families, were found in Christia plant extracts. (spandidos-publications.com)
  • We carried out the methanolic extracts of different parts of the plant by means of extraction with the Soxhlet equipment. (hindawi.com)
  • Prior studies have demonstrated that the extracts of plants utilized in the traditional Mayan medicine for the treatment of the signs and symptoms suggestive of cancer possess cytotoxic activity [ 6 ]. (hindawi.com)
  • It is expected to provide basic knowledge and skills related to production and chemical features of essences and extracts from local plants in Iberian Peninsula. (nottingham.ac.uk)
  • The tumors appear to be dying and then healing after treatment with cannabis-based extracts. (theweedblog.com)
  • In general, the essential oils from young and adult leaves of E. benthamii presented cytotoxicity against the investigated tumor cell lines which confirms their antitumor potential. (hindawi.com)
  • Since consumption of large quantities of fruit and vegetables is associated with a striking reduction in the risk of developing a variety of malignancies, it is of interest that a number of edible plants contain substantial quantities of compounds that regulate mammalian enzymes of xenobiotic metabolism. (pnas.org)
  • they are also useful for creating herbicide-resistant plants, and plants which contain mammalian polypeptides. (freepatentsonline.com)
  • Now, as discussed in the current issue of the Journal of Clinical Investigation , Gerard Blobe, M.D., Ph.D., and a team at Duke University have explored the tumor microenvironment and identified a mechanism by which tumors evade detection. (genengnews.com)
  • Preliminary studies have shown that taxol may have marginal activity in acute leukemia and melanoma, and some activity has been noted in other tumors. (google.com)
  • Plant tumors or galls usually form in response to the action of a pathogen or a pest. (harvard.edu)
  • [21] For example, plant galls have been characterized as tumors [22] but some authors argue that plants do not develop cancer. (wikipedia.org)
  • 1982) "Regeneration of normal and fertile plants that express octopine synthase, from tobacco crown galls after deletion of tumour-controlling functions," Nature 300:752-754. (freepatentsonline.com)
  • Lippard and Steinmetz continue to collaborate, investigating use of this system to deliver other drugs or drug candidates, use in other types of cancers, the addition of agents on the exterior of the shell to increase accumulation inside tumors and more. (teknoscienze.com)
  • The CRAG team used modified plants in which the circadian clock goes slower due to an increased and constant accumulation of TOC1, an essential component of the plant circadian clock. (cragenomica.es)
  • We studied the activity of 14 compounds, all of which have been shown to interfere in plant cell division, in two animal tumor cell cultures, EL-4 and L1210. (aacrjournals.org)
  • This is the first evidence that a plant-derived papillomavirus vaccine is protective in an animal model and is a proof of concept for human papillomavirus vaccines produced in plants. (asm.org)
  • In this study, we used the MUC1 TR peptide as a test antigen to determine whether a plant-expressed human tumour-associated antigen can be successfully expressed in a plant system and whether it will be able to break self-antigen tolerance in a MUC1-tolerant mouse model. (mysciencework.com)
  • The results indicate that a plant-derived human tumour-associated antigen is equivalent to the human antigen in the context of immune recognition. (mysciencework.com)
  • Between 1995 and 2005, human consumption of land plants increased from 20-25% of total plant production on the planet each year, with both total global consumption and per capita consuming rising over that period and continuing to rise. (treehugger.com)
  • If the entire human population consumed plant material like the average North American today, we would use more than 55% of all plants grown on the planet each year. (treehugger.com)
  • BERLIN: Treatment with a plant extract alleviates symptoms of Cushing Disease caused by a tumour in the brain, scientists say. (daily-sun.com)
  • 1. feverfew extract has a strong anti-tumor activity. (plant-extractpowder.com)
  • In this paper, we evaluated the cytotoxic potential of the extract of Bonellia albiflora , a plant utilized in the traditional Mayan medicine for treatment of chronic injuries of the mouth. (hindawi.com)
  • 10 Years Experience in Plant Extract The Best Service and The Best Price to Develop Overseas Markets. (made-in-china.com)
  • The cAMP pathway is also needed for subsequent fungal development in planta, as null mutants in any component of the pathway fail to form tumors. (apsnet.org)
  • We conclude that tight regulation of the cAMP pathway is crucial for fungal development within the plant but does not interfere with the tumor induction process. (apsnet.org)
  • Affirmatively, we now know that mutant p53 in humans causes an aggressive spread of a tumour by inhibiting the apoptotic pathway and cell cycle regulatory mechanisms. (europeanpharmaceuticalreview.com)
  • Here, we will provide a comprehensive picture of plant RIPs and discuss successful designs and features of chimeric molecules having therapeutic potential. (mdpi.com)
  • We report the expression of MUC1 TR peptide fused to the mucosal-targeting Escherichia coli enterotoxin B subunit (LTB-MUC1) in a plant host. (mysciencework.com)
  • In Nature this week: CRISPR approaches to editing plant genomes, way to speed up DNA-PAINT, and more. (genomeweb.com)
  • 1982) "Transformation in plants: potential and reality," (Abstract of Conference paper from University of Nottingham). (freepatentsonline.com)
  • The discovery, which is published this week in the journal Developmental Cell , was made using the model plant Arabidopsis thaliana . (cragenomica.es)
  • Plants have a long history of use in the treatment of cancer. (biomedcentral.com)
  • Patients usually die from a local recurrence of the tumor, even after aggressive treatment. (medindia.net)
  • However, in the case of Brucea javanica , it is one of those plants in which scientific investigations have provided enough evidence to prove that it has an impressive efficacy for the treatment of cervical, bladder and pancreatic cancers. (healthyaeon.com)
  • Although their pharmacological or toxicological properties have not been thoroughly investigated, infusions and decoctions of Eucalyptus plants are widely used in the treatment of respiratory diseases, for example, common cold, influenza, and sinus congestion [ 3 , 4 ]. (hindawi.com)
  • Plants that Fight Cancer, Second Edition, is a compilation that reviews cancer treatment and research-based information on the plant kingdom as the source of both known and novel chemical moieties and mixtures, many of them still under identification. (routledge.com)
  • The third part of the book comprises six chapters dedicated to either plant chemotherapeutical approaches to specific cancer types (e.g. bladder, prostate) or specific groups of plant secondary metabolites with novel and promising properties for cancer treatment (e.g. naphthoquinones, lectins, phenanthridone alkaloids). (routledge.com)
  • and plant lectins in cancer treatment. (routledge.com)
  • These pictures clearly show that this patient, with previously treatment-resistant tumors, continues to make obvious improvement. (theweedblog.com)

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