Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Balanced pre-emptive analgesia: does it work? A double-blind, controlled study in bilaterally symmetrical oral surgery. (1/254)We studied 32 patients undergoing bilateral symmetrical lower third molar surgery under general anaesthesia to determine if the combined effects of pre-emptive local anaesthetic block using 0.5% bupivacaine, together with i.v. tenoxicam and alfentanil had any benefits over postoperative administration. Patients acted as their own controls and were allocated randomly to have surgery start on one side, the second side always being the pre-emptive side. Difference in pain intensity between the two sides was determined using visual analogue scales completed by each individual at 6 h, and at 1, 3 and 6 days after operation. A long-form McGill pain questionnaire was also used to assess difference in pain intensity between the two sides on the morning after surgery. There was no significant difference in pain intensity at any time after surgery. Our findings indicate that the combined use of pre-emptive analgesia from 0.5% bupivacaine, tenoxicam and alfentanil did not reduce postoperative pain intensity in patients undergoing molar exodontia. (+info)
Tenoxicam and paracetamol-codeine combination after oral surgery: a prospective, randomized, double-blind, placebo-controlled study. (2/254)We studied 90 adults undergoing surgical removal of at least both lower third molar teeth as day cases under standardized general anaesthesia. Patients were allocated randomly (with stratification for surgeon) to receive tenoxicam 40 mg, tenoxicam 20 mg or placebo i.v. at induction of anaesthesia and orally (effervescent tablets) with food on each of the subsequent 2 days. Panadeine (paracetamol 500 mg-codeine 8 mg) was given before operation and was available as needed for pain thereafter, to a limit of two tablets every 4 h. Nefopam i.v. was also available. Efficacy variables and adverse reactions were assessed over 6 days. Over the 6-day period, patients who received tenoxicam reported less pain on rest (area under the curve; P < 0.05) and less disturbance in sleep (P < 0.01) even though they used fewer Panadeine tablets (P < 0.05). Differences between tenoxicam 40 mg and 20 mg were not significant. There was no significant difference in nefopam requirements or side effects, and no adverse event attributable to the study medication. (+info)
Evaluation of 5-aminosalicylic acid (5-ASA) for cancer chemoprevention: lack of efficacy against nascent adenomatous polyps in the Apc(Min) mouse. (3/254)Recent experimental and epidemiological evidence suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the prevention of colorectal cancer. However, the toxicity associated with the long-term use of most classical NSAIDs has limited their usefulness for the purpose of cancer chemoprevention. Inflammatory bowel disease (IBD) patients, in particular, are sensitive to the adverse side effects of NSAIDs, and these patients also have an increased risk for the development of intestinal cancer. 5-Aminosalicylic acid (5-ASA) is an anti-inflammatory drug commonly used in the treatment of IBD and may provide protection against the development of colorectal cancer in these patients. To directly evaluate the ability of 5-ASA to suppress intestinal tumors, we studied several formulations of 5-ASA (free acid, sulfasalazine, and Pentasa) at multiple oral dosage levels [500, 2400, 4800, and 9600 parts/million (ppm)] in the adenomatous polyposis coli (Apc) mouse model of multiple intestinal neoplasia (Min). Although the ApcMin mouse is not a model of colitis-associated neoplasia, it is, nonetheless, a useful model for assessing the ability of anti-inflammatory agents to prevent tumor formation in a genetically preinitiated population of cells. We used a study design in which drug was provided ad libitum through the diet beginning at the time of weaning (28 days of age) until 100 days of age. We included 200 ppm of piroxicam and 160 ppm of sulindac as positive controls, and the negative control was AIN-93G diet alone. Treatment with either piroxicam or sulindac produced statistically significant reductions in intestinal tumor multiplicity (95% and 83% reductions in tumor number, respectively; P < 0.001 versus controls). By contrast, none of the 5-ASA drug formulations or dosage levels produced consistent dose-progressive changes in polyp number, distribution, or size, despite high luminal and serum concentrations of 5-ASA and its primary metabolite N-acetyl-5-ASA. Thus, 5-ASA does not seem to possess direct chemosuppressive activity against the development of nascent intestinal adenomas in the ApcMin mouse. However, because intestinal tumor development in the ApcMin mouse is driven by a germline mutation in the Apc gene rather than by chronic inflammation, we caution that these findings do not definitively exclude the possibility that 5-ASA may exert a chemopreventive effect in human IBD patients. (+info)
Analgesic and anti-inflammatory efficacy of tenoxicam and diclofenac sodium after third molar surgery. (4/254)Tenoxicam and diclofenac sodium were compared with each other for analgesic efficacy following removal of third molars under general anesthesia. Thirty-five healthy patients between the ages of 18 and 28 yr were randomly allocated to two groups to participate in this study. Patients in Group A (n = 17) received a single intravenous injection of tenoxicam 40 mg at induction of anesthesia, followed by a 20-mg tablet given in the evening of the day of the operation and thereafter, one 20-mg tablet daily from days 2 to 7. Group B (n = 18) received a single intramuscular injection of diclofenac sodium 75 mg at induction of anesthesia, followed by a 50-mg tablet 4 to 6 hr after the operation and again, between 2100 hr and 2200 hr the same day. Thereafter, a 50-mg tablet was taken 3 times daily for the next 6 days. Pain was measured hourly for the first 4 hr postoperatively, then at 21 hr, and thereafter in the morning and the evenings on days 2 to 7. The highest pain scores were obtained 1 hr postoperatively for both trial groups. At 1 and 2 hr postoperatively, no statistical significant differences in pain scores could be shown for both groups. However, at 3 and 4 hr postoperatively, patients in the tenoxicam group experienced significantly (P < or = 0.05) less pain than those in the diclofenac sodium group. On the evening of the third postoperative day, the tenoxicam group of patients experienced significantly less pain (P < or = 0.05) than those in the diclofenac sodium group. This was again the case on the morning of the fourth postoperative day. On the fifth, sixth, and seventh postoperative days, the average pain scores for patients in the tenoxicam group were statistically significantly lower, both mornings and evenings, than those in the diclofenac sodium group of patients (P = 0.05). (+info)
Ankylosing spondylitis: what is the optimum duration of a clinical study? A one year versus a 6 weeks non-steroidal anti-inflammatory drug trial. (5/254)OBJECTIVE: To consider the relevance of the duration of a clinical trial in ankylosing spondylitis: long-term (i.e. 1 yr) vs short-term (i.e. 6 weeks) assessment of a non-steroidal anti-inflammatory drug (NSAID)-placebo controlled study. METHODS: The design was a prospective, multicentre, double-blind, placebo-controlled study of 6 weeks duration with a 12 months double-blind extension. Study drugs were placebo (n = 121) or active NSAID (n = 352). A decrease of at least 50% in pain and/or global assessment and/or functional impairment during the study defined the response to treatment. The percentage of patients discontinuing the study drug over time (life table analysis) permitted the evaluation of both the efficacy and toxicity. RESULTS: Among the 473 recruited patients, the percentage of responders was similar at 1 yr and week 6 with a highly statistically significant difference in favour of the active NSAID groups when compared to placebo (at 1 yr, 17% in the placebo group vs 37, 50 and 43% in the piroxicam 20 mg, meloxicam 15 mg and meloxicam 22.5 mg, respectively, for the patient's overall assessment) without any statistically significant difference between the three active groups. However, evaluation of the patients discontinuing the study drug during the 1 yr of the study permitted the detection of a statistically significant difference between the active NSAID groups. A lower percentage of patients taking meloxicam 22.5 mg had to discontinue the study drug when compared to either meloxicam 15 mg or piroxicam 20 mg (37% vs 53% and 53%, respectively, P < 0.05). By 52 weeks, drug-related upper gastrointestinal adverse events occurred in 13, 32, 20 and 18% in the placebo, piroxicam 20 mg, meloxicam 15 mg and meloxicam 22.5 mg groups, respectively. Some of the adverse events occurred only after week 6. CONCLUSION: This study suggests that a 1 yr trial might be of optimum value compared to a 6 week assessment in order to define better the efficacy and tolerability of NSAIDs in ankylosing spondylitis. (+info)
Transport of ochratoxin A by renal multispecific organic anion transporter 1. (6/254)In the present study, we investigated the transport of ochratoxin A (OTA) by kidney-specific organic anion transporter 1 (OAT1). When expressed in Xenopus laevis oocytes, OAT1 mediated sodium-independent uptake of OTA (Km = 2.1 microM). Piroxicam, which has been shown to prevent the nephrotoxicity of OTA, inhibited OAT1-mediated uptake of OTA. By contrast, another protective compound, aspartame, did not. Using a cell line derived from the mouse kidney terminal proximal tubule (S3) transfected with OAT1 cDNA, we investigated the transport of OTA and also its effect on cell proliferation and cell viability. S3 cells expressing OAT1 mediated the saturable transport of OTA (Km = 0.57 microM). Cell proliferation was suppressed in S3 cells expressing OAT1 when exposed to 2 and 10 microM OTA. This suppression was rescued by the coaddition of 1 mM p-aminohippurate in the media. The present study indicates that OTA is transported by OAT1 and that the accumulation of OTA via OAT1 in proximal tubular cells is the primary event in the development of OTA nephrotoxicity. (+info)
Physical activity, body mass index, and prostaglandin E2 levels in rectal mucosa. (7/254)BACKGROUND: Evidence suggests a relationship between prostaglandin levels in colonic mucosa and risk of colon cancer. Physical inactivity and a higher body mass index (BMI; weight in kilograms divided by [height in meters]2) have been consistently shown to increase risk of this cancer. We investigated whether higher levels of leisure-time physical activity or a lower BMI was associated with lower concentrations of prostaglandin E2 (PGE2) in rectal mucosa. METHODS: This study was conducted in 41 men and 22 women, 42-78 years of age, with a history of polyps, who participated in a randomized clinical trial testing the effects of piroxicam on rectal mucosal PGE2 levels. An [125I]PGE2 radioimmunoassay kit was used to determine PGE2 levels in samples of extracted rectal mucosa collected before randomization. Leisure-time physical activity was assessed through a self-administered questionnaire collected at baseline. The reported time spent at each activity per week was multiplied by its typical energy expenditure, expressed in metabolic equivalents (METs), to yield a MET-hours per week score. A repeated measures model was used to assess the effect of BMI and physical activity as predictors of PGE2 concentration. All statistical tests were two-sided. RESULTS: After adjustment for age, a higher BMI was associated with higher PGE2 levels (P = .001). A higher level of leisure-time physical activity was inversely associated with PGE2 concentration (P<.03). An increase in BMI from 24.2 to 28.8 kg/m2 was associated with a 27% increase in PGE2. An increase in activity level from 5.2 to 27.7 MET-hours per week was associated with a 28% decrease in PGE2. CONCLUSIONS: Physical activity and obesity may alter the risk of colon cancer through their effects on PGE2 synthesis. (+info)
The elimination profiles of tenoxicam and hydroxytenoxicam in equine urine and serum after a 200-mg oral dose. (8/254)Tenoxicam (Mobiflex) was administered orally to four standardbred mares at a dose of 200 mg. Elimination profiles of tenoxicam and hydroxytenoxicam were generated based on quantitation of these analytes in urine and serum by liquid chromatography (LC) with ultraviolet detection. Tenoxicam was confirmed by LC-tandem mass spectrometry daughter ion mass spectra in the last postadministration sample in which tenoxicam was detected. The tenoxicam and hydroxytenoxicam urinary elimination profiles had the same shape for the same horse; however, each horse was significantly different from the others. One horse (Horse 15) showed a much broader and flatter elimination profile than the other horses. Each horse had a peak in analyte concentration at different collection times. The latest detection for both tenoxicam and hydroxytenoxicam was 29-31 h for all horses. The urinary tenoxicam limit of detection (LOD) and limit of quantitation (LOQ) were 0.3 and 0.4 microg/mL, respectively. The urinary hydroxytenoxicam LOD and LOQ were 0.6 and 0.8 microg/mL, respectively. Hydroxytenoxicam was found to be completely conjugated and tenoxicam completely unconjugated in equine urine. Serum elimination profiles of tenoxicam were measured to 120 h postadministration. Hydroxytenoxicam was not detected in postadministration serum. The last serum tenoxicam detection was at the 24-h collection time for all horses. The peak average concentration was 434.5 ng/mL at 3 h. The serum tenoxicam LOD and LOQ were 5.7 and 7.3 ng/mL. (+info)
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Effect of Piroxicam on Ovulation - Full Text View - ClinicalTrials.gov
In this study the effect of piroxicam on the ovulation will be evaluated. Therefore piroxicam will be administered as a single-dose after onset of LH surge (luteinizing hormone, hormone which triggers ovulation).. Additionally blood levels of endogenous hormones (hormones produced by your body) will be measured and transvaginal ultrasound examinations will be conducted at regular intervals. In addition the concentration of piroxicam in blood will be determined in regular intervals.. With regards to the tolerability of the study drug subjects will be asked regularly how they feel. ...
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Animal data. Pregnant rats administered piroxicam at 2, 5, or 10 mg/kg/day during the period of organogenesis (Gestation Days 6 to 15) demonstrated increased post-implantation losses with 5 and 10 mg/kg/day of piroxicam (equivalent to 2 and 5 times the MRHD, of 20 mg respectively, based on a mg/m2 body surface area [BSA]). There were no drug-related developmental abnormalities noted in offspring. Gastrointestinal tract toxicity was increased in pregnant rats in the last trimester of pregnancy compared to non-pregnant rats or rats in earlier trimesters of pregnancy. Pregnant rabbits administered piroxicam at 2, 5, or 10 mg/kg/day during the period of organogenesis (Gestation Days 7 to 18) demonstrated no drug-related developmental abnormalities in offspring (up to 10 times the MRHD based on a mg/m2 BSA).. In a pre- and post-natal development study in which pregnant rats were administered piroxicam at 2, 5, or 10 mg/kg/day on Gestation Day 15 through delivery and weaning of offspring, reduced ...
Piroxicam nanoparticles for ocular delivery: Physicochemical characterization and implementation in endotoxin-induced uveitis ...
To investigate the anti-inflammatory impacts of piroxicam nanosuspension, in the current investigation, piroxicam:Eudragit RS100 nanoformulations were used to control inflammatory symptoms in the rabbits with endotoxin-induced uveitis (EIU). The nanoparticles of piroxicam:Eudragit RS100 was formulated using the solvent evaporation/extraction technique. The morphological and physicochemical characteristics of nanoparticles were studied using particle size analysis, X-ray crystallography, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). Drug release profiles were examined by fitting the data to the most common kinetic models. Selected nanosuspensions were used to assess the anti-inflammatory impacts of piroxicam nanoparticles in the rabbits with EIU. The major symptoms of EIU (i.e. inflammation and leukocytes numbers in the aqueous humor) were examined. All the prepared piroxicam formulations using Eudragit RS100 ...
UVAS Library catalog › Details for: Mutagenic And Cytotoxic Evaluartion Of Piroxicam And Meloxicam
DDC classification: 1548,T Dissertation note: Piroxicam and Meloxicam are enolic acid derivatives and belong to oxicam class of non steroidal anti-inflammatory drugs. They are therapeutically used in rheumatoid arthritis and osteoarthritis. This study was designed to evaluate mutagenicity and cytotoxicity of piroxicam and meloxicam by Ames Salmonella/microsome mutagenicity assay and MTT assay. In this study, ten concentrations (100µg/ml, 300µg/ml, 500µg/ml, 700µg/ml, 900µg/ml, 1000µg/ml, 3000µg/ml, 5000µg/ml, 7000µg/ml and 10,000µg/ml) of piroxicam and meloxicam were used in Ames test against Salmonella strain TA100 in plate incorporation method, with and without metabolic activation S-9 mixture in triplicate manner. In MTT assay, confluent monolayer of BHK-21 cell lines was used and grown in 96-well cell culture plates treated with same concentrations of both drugs in triplicate manner. The results indicated that piroxicam had no mutagenic potential at concentrations of 100µg/plate ...
Preparation and characterization of solid dispersions of piroxicam with hydrophillic carriers - Kent Academic Repository
The objective of this study was to improve the dissolution rate of a poor water soluble drug, piroxicam, by solid dispersion technique. Solid dispersions were prepared by three different methods depending on the type of carrier. The dissolution rate of piroxicam was markedly increased in solid dispersion of myrj 52, Eudragit® E100 and mannitol. Solubility studies revealed a marked increase in the solubility of piroxicam with an increase in myrj 52 and Eudragit® E100 concentrations. Data from the X-ray diffraction and FT-IR spectroscopy showed that piroxicam was amorphous in the solid dispersions prepared with dextrin and Eudragit® E100.. ...
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A comparison of analgesic efficacy of ketorolac and piroxicam for postoperative pain relief after cholecystectomy - Virtual...
postoperative pain management after cholecystectomy Settings:Department of Anaesthesiology and Intensive Care, PNS SHIFA, KARACHI Methodology:In this study, fifty patients who had to undergo cholecystectomy were randomized in two groups. The patients were monitored for 72 hours post operatively. The patients were ASA physical status of I and II, of both the sexes and aged between 30 to 60 years. A balanced anaesthetic technique was used for all the patients during the conduct of procedure. All the patients were operated through a standard subcostal incision [3 to 4 inches in length]. First dose of both the drugs was given immediately after induction [15 mg Ketorolac I/V or 20 mg Piroxicam I/M]. Postoperatively, group I patients received injection Ketorolac 15mg I/V8 hourly, group II patients were given injection Piroxicam 20mg I/M once daily. If pain persistently remained above 5 on VAS, injection Pethidine 50mg I/V p. m. was used as rescue analgesia for both the groups. In group I [ketorolac ...
Piroxicam and Meloxicam, the choice of drug - Medical diagnosis
It is impossible to say unequivocally about which drug is better. Treatment should be under the supervision of a doctor , with an appointment for a specific patient. Based on his analyzes, and the general condition of the body, concomitant diseases. But drawing a conclusion from the above, we can say that Meloxicam is less harmful to the body than Piroxicam. Meloxicam, unlike Piroxicam, does not interact with other drugs, which allows patients with concomitant diseases to take it, and this is an important factor in treatment.. Rheumatoid arthritis is one of the most common joint diseases today. Every hundredth inhabitant of the planet knows what joint inflammation is. This is especially true for women. They are 6 times more likely to be affected by this disease. Due to the general effort of the body, slowing down metabolic processes, the development and assimilation of various substances, such problems arise. This is due to heredity, lifestyle, human activities, so from the age of 30, there is a ...
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Treatment of Pain with a Topically Applied Combination of Indomethacin and Piroxicam
Author: Vetter Eric R, Curtis Lawrence, Year: 2002, Abstract: We evaluated 30 patient charts to determine the effectiveness of a topically applied combination of indomethacin and piroxicam in the treatment of osteopathologic pain of various intensities in hospice patients. The study was designed as a retrospective follow-up to determine whether that combination of drugs resulted in pain reduction. The level of pain experienced by each subject was noted at three intervals after the administration of the topical indomethacin and piroxicam combina
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CYP2C9 activity is reduced in individuals with genetic polymorphisms, such as the CYP2C9*2 and CYP2C9*3 polymorphisms. Limited data from two published reports showed that subjects with heterozygous CYP2C9*1/*2 (n=9), heterozygous CYP2C9*1/*3 (n=9), and homozygous CYP2C9*3/*3 (n=1) genotypes showed 1.7-, 1.7-, and 5.3-fold higher piroxicam systemic levels, respectively, than the subjects with CYP2C9*1/*1 (n=17, normal metabolizer genotype) following administration of a single oral dose. The mean elimination half-life values of piroxicam for subjects with CYP2C9*1/*3 (n=9) and CYP2C9*3/*3 (n=1) genotypes were 1.7- and 8.8-fold higher than subjects with CYP2C9*1/*1 (n=17). It is estimated that the frequency of the homozygous*3/*3 genotype is 0% to 1% in the population at large; however, frequencies as high as 5.7% have been reported in certain ethnic groups. ...
Efficacy of Piroxicam Plus Cisplatin-Loaded PLGA Nanoparticles in Inducing Apoptosis in Mesothelioma Cells
Cisplatin was encapsulated in 197 nm PLGA nanoparticles with 8.2% drug loading efficiency and 47% encapsulation efficiency. Cisplatin delivery from nanoparticles reaches 80% of total encapsulated drug in 14 days following a triphasic trend. PLGA nanoparticles in MSTO-211H cells were localized in the perinuclear space NP-C in combination with piroxicam induced apoptosis using a final cisplatin concentration 1.75 fold less than free drug. Delivered cisplatin cooperated with piroxicam in modulating cell cycle regulators as caspase-3, p53 and p21.. ...
IL PIROXICAM FDDF PER VIA SUBLINGUALE NEL TRATTAMENTO DELLARTRITE REUMATOIDE<...
TY - JOUR. T1 - IL PIROXICAM FDDF PER VIA SUBLINGUALE NEL TRATTAMENTO DELLARTRITE REUMATOIDE. AU - Montecucco, C.. AU - Caporali, R.. AU - Ronchetti, A.. AU - Rossi, S.. AU - Comaschi, E.. PY - 1994. Y1 - 1994. N2 - Open non-comparative study for the evaluation of the efficacy and tolerance of piroxicam FDDF for sublingual administration in the treatment of rheumatoid arthritis. Thirty patients (6 males and 24 females) suffering from rheumatoid arthritis in the active phase have been treated. All the patients had to fulfil the criteria for the rheumatoid arthritis classification proposed by the American Rheumatism Association (ARA). The efficacy of therapy has been evaluated, after 2, 4 and 6 week of treatment, through the changes in: the number of painful or tender joints on motion, the number of swollen joints, grip strength, ESR. Also day pain, night pain, duration of morning stiffness and functional index have been evaluated. As regards the functional index, activities as dressing, arising, ...
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Piroxicam: Side Effects, Dosages, Treatment, Interactions, Warnings
Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) indicated for the relief of the signs and symptoms of osteoarthritis and rheumatoid arthritis. Learn about side effects, drug interactions, dosages, warnings, and more.
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Piroxicam and carboplatin in canine oral non-tonsillar squamous cell carcinoma
Squamous cell carcinomas of the oral mucosa are known to be very aggressive and often very frustrating in their therapy. Does this combination of carboplatin and piroxicam coming from human medicine offer better therapeutic results than the current therapies? At least the preliminary results seems to be promising!
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piroxicam definition: a specific oxicam drug.; a nonsteroidal anti inflammatory medicine (trade name Feldene) familiar with treat joint disease also inflammatory circumstances
Optimization and Quality by Design Approach for Piroxicam Fast Dissolving Tablet Formulations Using Box-Behnken Design |...
Title:Optimization and Quality by Design Approach for Piroxicam Fast Dissolving Tablet Formulations Using Box-Behnken Design. VOLUME: 15 ISSUE: 2. Author(s):Harekrishna Roy*, Sisir Nandi, Ungarala Pavani, Uppuluri Lakshmi, Tamma Saicharan Reddy and Damarla Venkata Sri Gayatri. Affiliation:Department of Pharmaceutics, Nirmala College of Pharmacy, Mangalagiri, Guntur, Andhra Pradesh, 522503, Department of Pharmaceutical Chemistry, Global Institute of Pharmaceutical Education and Research, Affiliated to Uttarakhand Technical University, Kashipur-244713, Department of Pharmaceutics, Nirmala College of Pharmacy, Mangalagiri, Guntur, Andhra Pradesh, 522503, Department of Pharmaceutics, Nirmala College of Pharmacy, Mangalagiri, Guntur, Andhra Pradesh, 522503, Department of Pharmaceutics, Nirmala College of Pharmacy, Mangalagiri, Guntur, Andhra Pradesh, 522503, Department of Pharmaceutics, Nirmala College of Pharmacy, Mangalagiri, Guntur, Andhra Pradesh, 522503. Keywords:Fast dissolving tablet, ...
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Deformable Liposomes for the Transdermal Delivery of Piroxicam Abstract Objective: Deformable liposomes have been used to improve drugs transdermal delivery. These vesi..
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Light and temperature have considerable effect on the degradation of piroxicam in aqueous solutions. The pH and acetate buffer ions also affect the degradation process. The apparen..
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Background: Propofol is widely used for the induction and maintenance of general anaesthesia and offers many key attractive pharmacological qualities that make it suitable for these indications. However, pain on injection is one of its major drawbacks and can be very distressing to patients. There is a paucity of studies that have looked at the effect of lornoxicam on propofol injection pain either as a sole intervention or in combination with any other method. Primary objective: To determine whether premedication with intravenous lornoxicam had any effect on the intensity of propofol injection pain at induction of general anaesthesia in adult patients. Secondary Objectives: (I)To determine whether premedication with lornoxicam had any effect on the incidence of propofol injection pain at induction of general anaesthesia in adult patients.(II)To document any adverse events (allergic reactions, nausea, vomiting, gastritis and/or gastrointestinal bleeding, dizziness, phlebitis) that resulted from the
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Effect of curcumin extract (Curcuma xanthorrhiza) on Piroxicam-induced damage to the small intestine cells of mice (Mus...
Effect of curcumin extract (Curcuma xanthorrhiza) on Piroxicam-induced damage to the small intestine cells of mice (Mus musculus)
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Piroxicam (PX) is one of the most potent non-steroidal, antiinflammatory agents which also exhibit anti-pyretic activity in various types of non-rheumatic pains. Although..
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Transitional Cell Carcinoma (TCC) is the most common tumor of the canine urinary tract, causing nonresolving urinary signs (i.e., straining, hematuria) after it invades a large portion of the bladder and/or neighboring structures. Surgery may not be an option and chemotherapy represents the most common treatment; however, significant tumor reduction rarely occurs, resulting in a poor long-term outcome. Piroxicam, a non-steroidal anti-inflammatory drug, is one of the most effective compounds used to slow TCC progression. Piroxicam may also potentiate the effect of conventional chemotherapeutics, which are largely unrewarding when administered alone. Piroxicam targets cyclooxygenases (COX; proinflammatory enzymes), constitutively expressed by the bladder (COX-1) and overexpressed by the cancer (COX-2). Other inflammatory markers such as Lipoxigenase-5 (LOX-5) have been investigated in human TCCs, and found to be overexpressed compared to normal tissue. Importantly, in vitro studies have revealed that
Nonsteroidal Antiinflammatory Drugs - Restrictive Or Non-restrictive Hepatic-clearance | DIAL.pr - BOREAL
Based on their hepatic extraction ratio and unbound fraction in plasma or blood drugs can be categorized as being restrictively ol non-restrictively eliminated The general perception is that drugs with very small plasma clearances and extensive plasma protein binding, such as warfarin, are eliminated restrictively. However, based on literature data for 18 non-steroidal anti-inflammatory drugs (NSAIDs) with low plasma clearances (, 60 mll min), we have shown that most of these low-extraction compounds are non-restrictively eliminated ie. their hepatic extraction ratio exceeds their unbound action in plasma. For 4 NSAIDs considered in this survey, ie. phenylbutazone and the oxicams piroxicam, isoxicam and tenoxicam, the hepatic extraction ratio is smaller than their unbound fraction in plasma, and their hepatic elimination, therefore, is restrictive. Our conclusion that most low-clearance NSAIDs are non-restrictively extracted is based an a number of realistic assumptions concerning their ...
Transitional Cell Sarcomas in Dogs - Portland Veterinary Emergency and Specialty Care
Interestingly, though not anticancer drugs per se, piroxicam and other non-steroidal anti-inflammatory drugs (deracoxib, metacam) have shown activity against TCC in dogs. They can be used alone or in combination with chemotherapeutic agents.. Anti-inflammatory drugs can exert antitumor activity by several mechanisms. They appear to include reduction of swelling, pain, formation of new blood vessels in tumor tissue, and perhaps direct antitumor effects on malignant cells.. Piroxicam can be extremely useful in the management of TCC in dogs. It works rapidly to reduce tumor swelling and obstruction to urine outflow. As a single agent, it is known to control TCC for at least as long as multiple-drug protocols.. These drugs can be used safely in many dogs and cats. However, adverse reactions in the gastrointestinal tract (gastritis, vomiting, bleeding ulcers) and in renal (kidney) function have been reported. If your pet is taking such a drug, monitor him/her for signs of decreased appetite, ...
piroxicam Archives - Marie Spano, MS, RD, CSCS, CSSD
NSAIDs (non steroidal anti-inflammatory drugs) like ibuprofen (Advil) and indomethacin may speed up the breakdown of cartilage in osteoarthritic joints. They might also inhibit tissue repair. But, not all studies show NSAIDs damage cartilage. It may depend on the specific NSAID. The best study Ive seen to date (and also published in a very reputable journal) found older adults (a group that commonly has osteoarthritis) who used NSAIDs including diclofenac, ibuprofen, naproxen, ketoprofen and piroxican for an extended period of time had higher risk of cartilage defects and nonsignificant loss of cartilage compared to nonusers.. Osteoarthritis is very common (athletes, older adults, those who are overweight, those who have been very active their whole life) and is wear and tear arthritis; symptoms include joint pain and stiffness.. If you have mild osteoarthritis look for other solutions including curcumin, glucosamine and chondroitin sulfate, and boswella serrata AKBA.. ...
Comparison of Lornoxicam and Paracetamol for Pre-emptive Intravenous Analgesia for Elective Inguinal Hernia Repair - Full Text...
Early postoperative pain is the major cause that may restric physical activity of the patients and delay in returning work. Newer non-steroid analgesic drugs (NSAD) can be helpful in overcoming this problem, especially in pre-emptive use. In this prospective randomized placebo controlled double blinded study we aimed to determine whether lornoxicam, as a NSAD, or paracetamol is more effective in providing pre-emptive analgesia for patients undergo elective unilateral inguinal hernai repair under general anesthesia. 60 patients above the age of 18, ASA score of I to III will be assigned into 3 groups. All the patients will be operated under general anesthesia. Recurrent hernia cases, pregnant or lactated women, patients allergic to the two drugs, patients with documented gastric disorders or bleeding disorder or under anticoagulent therapy will be excluded.. Group designs:. Group I: 100 ml intravenous saline infusion as placebo 30 minitues before the surgery.. Group II: 8 mg intravenous ...
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Sci. Pharm. | Free Full-Text | Application of 14N NQR to the Study of Sulfanilamide, Piroxicam, and Nifedipine Polymorphism
14N NQR is a new method in pharmacy that has a potential to establish itself as an additional and valuable analytical tool for characterizing solid state of a substance . [...]
Gastrointestinal reaction to piroxicam | Veterinary Record
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Search | SciELO
Este trabalho investigou a margem de segurança do inibidor COX-2, meloxicam, em cães, enfocando seus efeitos deletérios nas células sangüíneas e no trato gastrintestinal. Para tanto, após uma avaliação clínico-laboratorial, os cães foram distribuídos nos seguintes grupos: I (placebo; n= 3), II (piroxicam; 1,0mg kg-1; n= 5), III (meloxicam; 0,2mg kg-1; n= 5), IV (meloxicam;1,0mg kg-1; n= 5) e V (meloxicam; 2,0mg kg-1; n= 5). Os fármacos foram usados, por via oral, por 16 dias. No 17º dia, repetiu-se o hemograma completo e, então, procedeu-se a eutanásia seguida pela necrópsia. No grupo I, não houve alterações dignas de nota. No grupo II, todos os cães apresentaram episódios moderados de vômito e diarréia. O perfil celular sangüíneo não foi significativamente modificado. Em dois cães, houve redução no hematócrito e na hemoglobina. Na necropsia, observaram-se focos hemorrágicos e lesões gastriduodenais moderadas. A análise microscópica revelou a presença de ...
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3. Drug Mode of Action :: Piroxicam is a NSAID, belonging to the oxicam group. It inhibits prostaglandin synthesis, reduces fever by acting on the heat-regulating center of the hypothalamus, inhibits platelet-aggregating substance thromboxane A2 and reduces pain receptor sensitivity. It also exerts anti-inflammatory effect by lysosomal stabilisation, kinin and leukotriene production, alteration of chemotactic factors and neutrophil activation inhibition.. Drug Interactions ::. Increased risk of GI bleeding w/ anti-platelets and SSRIs. May exacerbate cardiac failure, reduce GFR and increase plasma glycoside levels. Increased risk of nephrotoxicity w/ ciclosporin and tacrolimus. Increased absorption w/ cimetidine. Increased risk of GI ulceration w/ corticosteroids. May interfere w/ the natriuretic action of diuretics. May displace other highly protein-bound drugs. May increase steady state plasma lithium levels. May antagonise the effect of antihypertensives. May reduce the excretion of ...
Saras blog: December 2010
Im really hoping we dont get to the third option. I dont want to knock Misty out, or put her through surgery at her age. My philosophy for my pets at this stage is maintaining quality of life, not performing procedures to add months to it. So, option three will need to be explained more fully if we get to that point.. The internist did prescribe piroxicam to help with the inflammation. The added benefit is that this drug has been proven to shrink bladder tumors in some dogs, including my Munchkin, who saw amazing results from the drug.. Overall, I think the doctor believes Mistys problem is most likely a stubborn bug, that requires a rarely used antibiotic, BUT.....ugh!. ...
Survival analysis of dogs with advanced primary lung carcinoma
treated by metronomic cyclophosphamide, piroxicam and thalidomide Unresectable or metastatic (advanced) primary pulmonary carcinoma (PPC) represents a...
Big Dog, Pig Dog - We have achieved two months!
Where are we now…well, the S.A. is definitely getting worse (and the vet suspects he may also be Addisonian, as well), so his hair loss is getting worse and worse. (Except for the one wee patch that grew back on a section of his stump, and his face and legs) Trying to fight cancer makes fighting the other stuff all the harder, I guess. But the hair is cosmetic, and really not that much different. In fact, he probably would have lost it anyway-each time we blow our coat, more goes away and never comes back. John, our PT, calls him the worlds largest Chinese Crested :p. We are finally eating now, after switching to Prednisone over Piroxicam. Weve lost the anti-tumour benefits of pirox., but if hes not eating, hes not living…so Pred. it is.. He continues to lose weight, however. Dropped to 70 lbs. post amp, then 10 days ago we were at 68. Two days ago, we were down to 63.5. BUT his bloodwork looks fine, so it is what it is, I suppose.. We do some PT every day…mostly walks, which he ...
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Dissolved oxygen is the amount of gaseous O2 in an aqueous solution. This is often used to analyze the health of a body of water. It is important to have ample dissolved oxygen in order for there to be aerobic life in water. Low concentrations of dissolved oxygen lead to stress for many organisms and can lead to large fish kills. ...
- FELDENE (piroxicam) capsule is a nonsteroidal anti-inflammatory drug, available as maroon and blue #322 10 mg capsules and maroon #323 20 mg capsules for oral administration. (pfizermedicalinformation.com)
- Do not take an NSAID such as piroxicam if you have recently had a heart attack, unless directed to do so by your doctor. (medlineplus.gov)
- Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class used to relieve the symptoms of painful inflammatory conditions like arthritis . (wikipedia.org)
- Piroxicam is an NSAID and, as such, is a non-selective COX inhibitor possessing both analgesic and antipyretic properties. (wikipedia.org)
- Piroxicam is an NSAID that is used to treat some cancers in dogs and cats and, to a lesser degree, for pain due to osteoarthritis. (zuchepharma.com)
- Piroxicam Injection is known as a nonsteroidal anti-inflammatory drug (NSAID). (mausdipharmaceuticals.com)
- Piroxicam is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). (medlineplus.gov)
- IMSEAR at SEARO: Comparative study of piroxicam and ibuprofen in rheumatoid arthritis. (who.int)
- Piroxicam was compared with ibuprofen in a 8 weeks randomised open clinical trial in 31 patients (16 patients with piroxicam and 15 patients with ibuprofen) with rheumatoid arthritis. (who.int)
- In this volume on non-steroidal anti-inflammatory drugs the following drugs are reviewed: Aspirin, Sulindac, Piroxicam and Indomethacin. (who.int)
- Piroxicam may be combined with analgesic drugs to manage pain in cancer patients. (zuchepharma.com)
- In other words (or in clinical terms), Brexin has a more potent analgesic and anti-inflammatory effect as compare to plain Piroxicam. (plaintips.com)
- Multimodal analgesic combination of pentazocine and piroxicam showed superior analgesic effect with better pain control and longer duration of action compared to pentazocine alone. (ijbcp.com)
- Piroxicam comes as a capsule to take by mouth. (medlineplus.gov)
Determination of piroxicam4
- A simple and reliable novel kinetic method for the determination of piroxicam (PX) was proposed and validated. (degruyter.com)
- Applicability of the proposed method to the direct determination of piroxicam in different pharmaceutical formulations (tablets, ampoules and gel) was demonstrated. (degruyter.com)
- Simultaneous determination of piroxicam and its major metabolite 5'-hydroxypiroxicam in human plasma by derivative spectrophotometry. (semanticscholar.org)
- Extractionless high-performance liquid chromatographic method for the simultaneous determination of piroxicam and 5'-hydroxypiroxicam in human plasma and urine. (semanticscholar.org)
- One of the dosage forms available for Piroxicam is Gourmeds Chewable Tablets. (wedgewoodpharmacy.com)
- 2 strengths of Piroxicam Gourmeds Chewable Tablets are available in 5 mg/tab. (wedgewoodpharmacy.com)
- Keep reading to discover how it works and why Brexin Tablets are superior to Piroxicam alone. (plaintips.com)
- The half-life of Brexin Tablets is same as plain Piroxicam, which is longer than the most NSAIDs . (plaintips.com)
- Brexin Tablets (and plain Piroxicam) may affect concentration and it is therefore not advisable to drive or undertake any activity requiring quick reflex action. (plaintips.com)
- 2 tablets of 'piroxicam (piroxan)' administrated orally once per 24 hours. (clinicaltrials.gov)
-  It is also available in a betadex formulation, which allows a more rapid absorption of piroxicam from the digestive tract. (wikipedia.org)
- It is a relatively new formulation of Piroxicam as a complex with β-cyclodextrin . (plaintips.com)
- 2022). 'Evaluation Of Piroxicam Conventional and Hollow Suppositories Formulation', European Journal of Molecular & Clinical Medicine , 9(3), pp. 10616-10620. (ejmcm.com)
- People who take nonsteroidal anti-inflammatory medications (NSAIDs) (other than aspirin) such as piroxicam may have a higher risk of having a heart attack or a stroke than people who do not take these medications. (medlineplus.gov)
- NSAIDs such as piroxicam may cause ulcers, bleeding, or holes in the stomach or intestine. (medlineplus.gov)
- The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while you are taking piroxicam. (medlineplus.gov)
- Piroxicam is in a class of medications called NSAIDs. (medlineplus.gov)
-  Piroxicam is one of the few NSAIDs that can be given parenteral routes. (wikipedia.org)
- Brexin, plain Piroxicam and other NSAIDs, decrease platelet aggregation and prolong bleeding. (plaintips.com)
- Piroxicam belongs to the group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). (pharmasave.com)
- Piroxicam is a nonselective cyclooxygenase inhibitor with inhibitory effects produces prostaglandins that regulate homeostasis, allowing the kidney to respond to hypotension and protect the GI tract. (zuchepharma.com)
- Piroxicam Injection is the one used to reduce swelling, pain, and joint stiffness from arthritis. (mausdipharmaceuticals.com)
- Piroxicam is well-absorbed orally and the absorption is not affected by the presence of antacids. (zuchepharma.com)
- Significant inflammation was induced in the ileum of SAMP1/Yit mice at 23 wk of age after piroxicam treatment for 3 wk. (curehunter.com)
- Piroxicam blocks the release of certain chemical messengers that are responsible for inflammation, pain, and fever. (actizapharmaceutical.com)
- 2-Suppositories with piroxicam powder or solution in a hollow kind. (ejmcm.com)
- The minimum level of statistical significance was defined as a probability value (p0.05).In comparison to corresponding conventional suppositories (F1, F2, F4, and F5) and hollow suppositories loaded with Piroxicam in powder form (F6-F9) containing the same base, Piroxicam released faster with a higher percentage from hollow suppositories loaded with Piroxicam in solution form (F10-F13) in addition to their best physical properties. (ejmcm.com)
- The once daily administration gives piroxicam a clear practical advantage over ibuprofen. (who.int)
- Objectives of the study was to compare the efficacy and safety of pentazocine and its combination with piroxicam in the management of post cesarean pain. (ijbcp.com)
- After oral administration, Brexin has a quicker absorption as compare to Piroxicam alone because it is highly soluble in water. (plaintips.com)
- This rapid absorption leads to a faster increase in plasma levels and Bexin achieves peak plasma concentration much earlier than plain Piroxicam. (plaintips.com)
Soluble in water1
- Piroxicam occurs as a white crystalline solid, sparingly soluble in water, dilute acid, and most organic solvents. (pfizermedicalinformation.com)
- Quantification of piroxicam and 5'-hydroxypiroxicam in human plasma and saliva using liquid chromatography-tandem mass spectrometry following oral administration. (semanticscholar.org)
- The secondary objectives was to evaluate the maternal tolerance of the drugs (piroxicam, nefopam, paracetamol) used postoperatively of a caesarean section. (clinicaltrials.gov)
- Piroxicam is also sometimes used to treat gouty arthritis (attacks of severe joint pain and swelling caused by a build-up of certain substances in the joints) and ankylosing spondylitis (arthritis that mainly affects the spine). (medlineplus.gov)
- If you experience any of the following symptoms, stop taking piroxicam and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. (medlineplus.gov)
-   Piroxicam works by preventing the production of endogenous prostaglandins which are involved in the mediation of pain, stiffness, tenderness and swelling. (wikipedia.org)
- Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to piroxicam. (medlineplus.gov)
- Piroxicam will help control your symptoms but will not cure your condition. (medlineplus.gov)
- Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to piroxicam or any components of the drug product. (pfizermedicalinformation.com)
- Dynamics of excited-state intramolecular proton transfer reactions in piroxicam. (elsevier.com)
- Piroxicam exists as alkenol tautomer in organic solvents and as zwitterionic form in water. (wikipedia.org)
- The pharmacokinetics of piroxicam in elderly persons with and without renal impairment. (semanticscholar.org)
- Herein, we report that for certain weakly acidic biopharmaceutical classification system (BCS) class II molecules (piroxicam, PIRO), physiologically based PK (PBPK) modeling could be used as a tool to quantitatively predict PK in beagle dogs and to conduct an interspecies extrapolation to humans. (simulations-plus.com)
- Piroxicam is excreted primarily in the urine and only about 1% of the plasma level is found in milk. (zuchepharma.com)
- The detection of piroxicam, tenoxicam and their metabolites in equine urine by electrospray ionisation ion trap mass spectrometry. (semanticscholar.org)
- High-performance liquid chromatographic analysis of piroxicam and its major metabolite 5'-hydroxypiroxicam in human plasma and urine. (semanticscholar.org)
- Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with piroxicam and each time you refill your prescription. (medlineplus.gov)