Picobirnavirus
RNA Virus Infections
Genogroup I picobirnaviruses in pigs: evidence for genetic diversity and relatedness to human strains. (1/13)
(+info)Molecular characterization of porcine picobirnaviruses and development of a specific reverse transcription-PCR assay. (2/13)
(+info)The picobirnavirus crystal structure provides functional insights into virion assembly and cell entry. (3/13)
(+info)Molecular characterization of full-length genomic segment 2 of a bovine picobirnavirus (PBV) strain: evidence for high genetic diversity with genogroup I PBVs. (4/13)
(+info)Human picobirnaviruses identified by molecular screening of diarrhea samples. (5/13)
(+info)Structure of Fusarium poae virus 1 shows conserved and variable elements of partitivirus capsids and evolutionary relationships to picobirnavirus. (6/13)
(+info)Backbone trace of partitivirus capsid protein from electron cryomicroscopy and homology modeling. (7/13)
(+info)Metagenomic analysis of the turkey gut RNA virus community. (8/13)
(+info)Picobirnavirus is a genus of non-enveloped, double-stranded RNA viruses in the family *Birnaviridae* that are typically associated with gastrointestinal illness in humans and animals. These viruses are characterized by their small size (picorna-like) and bi-segmented genome. They are often found in fecal samples and are transmitted through the fecal-oral route, but their exact role in disease pathogenesis is not well understood and further research is needed.
RNA virus infections refer to diseases or conditions caused by the invasion and replication of RNA (Ribonucleic acid) viruses in host cells. These viruses use RNA as their genetic material, which is different from DNA (Deoxyribonucleic acid) viruses. Upon entering a host cell, the RNA virus releases its genetic material, which then uses the host cell's machinery to produce new viral components and replicate. This process can lead to various outcomes, depending on the specific virus and the host's immune response:
1. Asymptomatic infection: Some RNA virus infections may not cause any noticeable symptoms and may only be discovered through diagnostic testing.
2. Acute infection: Many RNA viruses cause acute infections, characterized by the rapid onset of symptoms that typically last for a short period (days to weeks). Examples include the common cold (caused by rhinoviruses), influenza (caused by orthomyxoviruses), and some gastrointestinal infections (caused by noroviruses or rotaviruses).
3. Chronic infection: A few RNA viruses can establish chronic infections, where the virus persists in the host for an extended period, sometimes leading to long-term health complications. Examples include HIV (Human Immunodeficiency Virus), HCV (Hepatitis C Virus), and HTLV-1 (Human T-lymphotropic virus type 1).
4. Latent infection: Some RNA viruses, like herpesviruses, can establish latency in the host, where they remain dormant for extended periods but can reactivate under certain conditions, causing recurrent symptoms or diseases.
5. Oncogenic potential: Certain RNA viruses have oncogenic properties and can contribute to the development of cancer. For example, retroviruses like HTLV-1 can cause leukemia and lymphoma by integrating their genetic material into the host cell's DNA and altering gene expression.
Treatment for RNA virus infections varies depending on the specific virus and the severity of the infection. Antiviral medications, immunotherapy, and supportive care are common treatment strategies. Vaccines are also available to prevent some RNA virus infections, such as measles, mumps, rubella, influenza, and hepatitis A and B.