The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to its sugar substrates (the PTS sugars) concomitant with the translocation of these sugars across the bacterial membrane. The phosphorylation of a given sugar requires four proteins, two general proteins, Enzyme I and HPr and a pair of sugar-specific proteins designated as the Enzyme II complex. The PTS has also been implicated in the induction of synthesis of some catabolic enzyme systems required for the utilization of sugars that are not substrates of the PTS as well as the regulation of the activity of ADENYLYL CYCLASES. EC 2.7.1.-.
A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.
The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The protein complement of an organism coded for by its genome.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
A reagent used mainly to induce experimental liver cancer. According to the Fourth Annual Report on Carcinogens (NTP 85-002, p. 89) published in 1985, this compound "may reasonably be anticipated to be a carcinogen." (Merck, 11th ed)
A very potent liver carcinogen.
A group of enzymes that catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate. They are found in invertebrates and microorganisms, and are highly specific for glucose. (Enzyme Nomenclature, 1992) EC 2.7.1.2.
Excision of all or part of the liver. (Dorland, 28th ed)
An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-Glucose, D-mannose, D-fructose, sorbitol, and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. (From Enzyme Nomenclature, 1992) EC 2.7.1.1.
Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.
The channels that collect and transport the bile secretion from the BILE CANALICULI, the smallest branch of the BILIARY TRACT in the LIVER, through the bile ductules, the bile ducts out the liver, and to the GALLBLADDER for storage.
Substances used to destroy or inhibit the action of rats, mice, or other rodents.
The reduction or regulation of the population of noxious, destructive, or dangerous rodents through chemical, biological, or other means.
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants.
A genus of fleas in the family Pulicidae which includes the species that serves as the primary vector of BUBONIC PLAGUE, Xenopsylla cheopis.
A group of enzymes that catalyzes the transfer of a phosphate group onto a nitrogenous group acceptor. EC 2.7.3.
Proteins found in any species of bacterium.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.
Common name for the order Pleuronectiformes. A very distinctive group in that during development they become asymmetrical, i.e., one eye migrates to lie adjacent to the other. They swim on the eyeless side. FLOUNDER, sole, and turbot, along with several others, are included in this order.
A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.
Substances elaborated by specific strains of bacteria that are lethal against other strains of the same or related species. They are protein or lipopolysaccharide-protein complexes used in taxonomy studies of bacteria.
The portion of an interactive computer program that issues messages to and receives commands from a user.
In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.
A highly branched glucan in starch.
Sequential operating programs and data which instruct the functioning of a digital computer.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
High molecular weight, insoluble polymers which contain functional groups that are capable of undergoing exchange reactions (ION EXCHANGE) with either cations or anions.
A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Proteins obtained from ESCHERICHIA COLI.
The units based on political theory and chosen by countries under which their governmental power is organized and administered to their citizens.
The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide using energy obtained from light rather than from the oxidation of chemical compounds. Photosynthesis comprises two separate processes: the light reactions and the dark reactions. In higher plants; GREEN ALGAE; and CYANOBACTERIA; NADPH and ATP formed by the light reactions drive the dark reactions which result in the fixation of carbon dioxide. (from Oxford Dictionary of Biochemistry and Molecular Biology, 2001)
An enzyme that catalyzes the reaction of ATP, pyruvate, and orthophosphate to form AMP plus phosphoenolpyruvate plus pyrophosphate. EC 2.7.9.1.
Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene. (1/3825)

We have identified a novel fibroblast growth factor receptor 3 (FGFR3) missense mutation in four unrelated individuals with skeletal dysplasia that approaches the severity observed in thanatophoric dysplasia type I (TD1). However, three of the four individuals developed extensive areas of acanthosis nigricans beginning in early childhood, suffer from severe neurological impairments, and have survived past infancy without prolonged life-support measures. The FGFR3 mutation (A1949T: Lys650Met) occurs at the nucleotide adjacent to the TD type II (TD2) mutation (A1948G: Lys650Glu) and results in a different amino acid substitution at a highly conserved codon in the kinase domain activation loop. Transient transfection studies with FGFR3 mutant constructs show that the Lys650Met mutation causes a dramatic increase in constitutive receptor kinase activity, approximately three times greater than that observed with the Lys650Glu mutation. We refer to the phenotype caused by the Lys650Met mutation as "severe achondroplasia with developmental delay and acanthosis nigricans" (SADDAN) because it differs significantly from the phenotypes of other known FGFR3 mutations.  (+info)

Presynaptic inhibition of GABA(B)-mediated synaptic potentials in the ventral tegmental area during morphine withdrawal. (2/3825)

Opioids increase the firing of dopamine cells in the ventral tegmental area by presynaptic inhibition of GABA release. This report describes an acute presynaptic inhibition of GABAB-mediated IPSPs by mu- and kappa-opioid receptors and the effects of withdrawal from chronic morphine treatment on the release of GABA at this synapse. In slices taken from morphine-treated guinea pigs after washing out the morphine (withdrawn slices), a low concentration of a mu receptor agonist increased, rather than decreased, the amplitude of the GABAB IPSP. In withdrawn slices, after blocking A1-adenosine receptors with 8-cyclopentyl-1, 3-dipropylxantine, mu-opioid receptor activation inhibited the IPSP at all concentrations and increased the maximal inhibition. In addition, during withdrawal, there was a tonic increase in adenosine tone that was further increased by forskolin or D1-dopamine receptor activation, suggesting that metabolism of cAMP was the source of adenosine. The results indicate that during acute morphine withdrawal, there was an upregulation of the basal level of an opioid-sensitive adenylyl cyclase. Inhibition of this basal activity by opioids had two effects. First, a decrease in the formation of cAMP that decreased adenosine tone. This effect predominated at low mu receptor occupancy and increased the amplitude of the IPSP. Higher agonist concentrations inhibited transmitter release by both kinase-dependent and -independent pathways. This study indicates that the consequences of the morphine-induced upregulation of the cAMP cascade on synaptic transmission are dependent on the makeup of receptors and second messenger pathways present on any given terminal.  (+info)

The mouse Y-box protein, MSY2, is associated with a kinase on non-polysomal mouse testicular mRNAs. (3/3825)

In male germ cells many mRNAs are sequestered by proteins into translationally silent messenger ribo-nucleoprotein (mRNP) particles. These masked paternal mRNAs are stored and translated at specific times of germ cell development. Little is known about the mammalian testicular mRNA masking proteins bound to non-polysomal mRNAs. In this report, the major proteins binding to non-polysomal testicular mRNAs were isolated and analyzed. The two predominant proteins identified were: a Y-box protein (MSY2), the mammalian homolog to the Xenopus oocyte masking protein FRGY2/mRNP3+4, and a poly(A) binding protein. A kinase activity was also found associated with these non-polysomal RNAs. The kinase co-immunoprecipitates with MSY2 and phosphorylates MSY2 in vitro. The MSY2 associated kinase is not casein kinase 2, the kinase believed to phosphorylate mRNP3+4 in oocytes, but a yet unidentified kinase. MSY2 was found to be phosphorylated in vivo and MSY2 dephosphorylation led to a decrease in its affinity to bind RNA as judged by northwestern blotting. Therefore, testicular masked mRNAs may be regulated by the phosphorylation state of MSY2. Reconstitution experiments in which non-polysomal mRNA-binding proteins are dissociated from their RNAs and allowed to bind to exogenous mRNAs suggest that MSY2 binds RNA in a sequence-independent fashion. Furthermore, association of the non-polysomal derived proteins to exogenous non-specific mRNAs led to their translational repression in vitro.  (+info)

A superfamily of metalloenzymes unifies phosphopentomutase and cofactor-independent phosphoglycerate mutase with alkaline phosphatases and sulfatases. (4/3825)

Sequence analysis of the probable archaeal phosphoglycerate mutase resulted in the identification of a superfamily of metalloenzymes with similar metal-binding sites and predicted conserved structural fold. This superfamily unites alkaline phosphatase, N-acetylgalactosamine-4-sulfatase, and cerebroside sulfatase, enzymes with known three-dimensional structures, with phosphopentomutase, 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, phosphoglycerol transferase, phosphonate monoesterase, streptomycin-6-phosphate phosphatase, alkaline phosphodiesterase/nucleotide pyrophosphatase PC-1, and several closely related sulfatases. In addition to the metal-binding motifs, all these enzymes contain a set of conserved amino acid residues that are likely to be required for the enzymatic activity. Mutational changes in the vicinity of these residues in several sulfatases cause mucopolysaccharidosis (Hunter, Maroteaux-Lamy, Morquio, and Sanfilippo syndromes) and metachromatic leucodystrophy.  (+info)

The cellular distribution and kinase activity of the Cdk family member Pctaire1 in the adult mouse brain and testis suggest functions in differentiation. (5/3825)

Pctaire1, a member of the family of cyclin-dependent kinases, has been shown to be particularly abundantly expressed in differentiated tissues such as testis and brain. However, very little is known about the cellular and subcellular distribution and function of Pctaire1 protein(s), which is the focus of this study. We show that Pctaire1 encoded two major proteins of M(r) approximately 62,000 and approximately 68,000, found predominantly in testis and brain. Within these two tissues, Pctaire1 was most abundant in the cytoplasm of terminally differentiated cells, notably, the pyramidal neurons in brain and elongated spermatids in testis. Immunoprecipitation experiments further showed that a kinase activity toward myelin basic protein was associated with Pctaire1 in the adult testis and brain and that its activity was potentially regulated through association with regulatory partner(s). These results suggest that Pctaire1 kinase might have an important role in differentiated cells such as postmitotic neurons and spermatogenic cells.  (+info)

Involvement of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system in regulation of transcription of catabolic genes. (6/3825)

Synthesis of catabolite-sensitive enzymes is repressed in mutants defective in the general proteins (enzyme I and HPr) of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system (ptsI and ptsH mutations). To elucidate the mechanism of this phenomenon we constructed isogenic strains carrying pts mutations as well as different lesions of regulation of the lac operon or mutations affecting adenylate cyclase activity (cya mutation) and synthesis of cyclic AMP-receptor protein (crp mutation) Measurements of the differential rate of beta-galactosidase synthesis in these strains showed that the repressive effect of pts mutations was revealed in lac+, lacI, lacOc and cya bacteria, but it was lost in lacP and crp strains. It was concluded that mutational damage to the general components of the phosphoenolpyruvate-dependent phosphotransferase system diminishes activity of the lac promoter. The results obtained led to the conclusion that pts gene products (apparently phospho approximately HPr) are necessary for the initiation of transcription of catabolite-sensitive operons in E. coli.  (+info)

In vivo regulation of glycolysis and characterization of sugar: phosphotransferase systems in Streptococcus lactis. (7/3825)

Two novel procedures have been used to regulate, in vivo, the formation of phosphoenolpyruvate (PEP) from glycolysis in Streptococcus lactis ML3. In the first procedure, glucose metabolism was specifically inhibited by p-chloromercuribenzoate. Autoradiographic and enzymatic analyses showed that the cells contained glucose 6-phosphate, fructose 6-phosphate, fructose-1,6-diphosphate, and triose phosphates. Dithiothreitol reversed the p-chloromercuribenzoate inhibition, and these intermediates were rapidly and quantitatively transformed into 3- and 2-phosphoglycerates plus PEP. The three intermediates were not further metabolized and constituted the intracellular PEP potential. The second procedure simply involved starvation of the organisms. The starved cells were devoid of glucose 6-phosphate, fructose 6-phosphate, fructose- 1,6-diphosphate, and triose phosphates but contained high levels of 3- and 2-phosphoglycerates and PEP (ca. 40 mM in total). The capacity to regulate PEP formation in vivo permitted the characterization of glucose and lactose phosphotransferase systems in physiologically intact cells. Evidence has been obtained for "feed forward" activation of pyruvate kinase in vivo by phosphorylated intermediates formed before the glyceraldehyde-3-phosphate dehydrogenase reaction in the glycolytic sequence. The data suggest that pyruvate kinase (an allosteric enzyme) plays a key role in the regulation of glycolysis and phosphotransferase system functions in S. lactis ML3.  (+info)

A phosphotransferase that generates phosphatidylinositol 4-phosphate (PtdIns-4-P) from phosphatidylinositol and lipid A in Rhizobium leguminosarum. A membrane-bound enzyme linking lipid a and ptdins-4-p biosynthesis. (8/3825)

Membranes of Rhizobium leguminosarum contain a 3-deoxy-D-manno-octulosonic acid (Kdo)-activated lipid A 4'-phosphatase required for generating the unusual phosphate-deficient lipid A found in this organism. The enzyme has been solubilized with Triton X-100 and purified 80-fold. As shown by co-purification and thermal inactivation studies, the 4'-phosphatase catalyzes not only the hydrolysis of (Kdo)2-[4'-32P]lipid IVA but also the transfer the 4'-phosphate of Kdo2-[4'-32P]lipid IVA to the inositol headgroup of phosphatidylinositol (PtdIns) to generate PtdIns-4-P. Like the 4'-phosphatase, the phosphotransferase activity is not present in Escherichia coli, Rhizobium meliloti, or the nodulation-defective mutant 24AR of R. leguminosarum. The specific activity for the phosphotransferase reaction is about 2 times higher than that of the 4'-phosphatase. The phosphotransferase assay conditions are similar to those used for PtdIns kinases, except that ATP and Mg2+ are omitted. The apparent Km for PtdIns is approximately 500 microM versus 20-100 microM for most PtdIns kinases, but the phosphotransferase specific activity in crude cell extracts is higher than that of most PtdIns kinases. The phosphotransferase is absolutely specific for the 4-position of PtdIns and is highly selective for PtdIns as the acceptor. The 4'-phosphatase/phosphotransferase can be eluted from heparin- or Cibacron blue-agarose with PtdIns. A phosphoenzyme intermediate may account for the dual function of this enzyme, since a single 32P-labeled protein species (Mr approximately 68,000) can be trapped and visualized by SDS gel electrophoresis of enzyme preparations incubated with Kdo2-[4'-32P]lipid IVA. Although PtdIns is not detected in cultures of R. leguminosarum/etli (CE3), PtdIns may be synthesized during nodulation or supplied by plant membranes, given that soybean PtdIns is an excellent phosphate acceptor. A bacterial enzyme for generating PtdIns-4-P and a direct link between lipid A and PtdIns-4-P biosynthesis have not been reported previously.  (+info)

selenophosphate synthetase: involved in selenium metabolism; gamma-phosphate of ATP is transferred to HSe resulting in formation of monoselenophosphate; amino acid sequence in first source
Tabeling C, Yu H, Wang L, Ranke H, Goldenberg NM, Zabini D, Noe E, Krauszman A, Gutbier B, Yin J, Schaefer M, Arenz C, Hocke AC, Suttorp N, Proia RL, Witzenrath M, Kuebler WM. CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction. Proc Natl Acad Sci U S A. 2015 Mar 31; 112(13):E1614-23 ...
SEPHS2 antibody (selenophosphate synthetase 2) for ICC/IF, IHC-P, WB. Anti-SEPHS2 pAb (GTX103766) is tested in Human samples. 100% Ab-Assurance.
phospho-N-acetylmuramoyl pentapeptide transferase: enzyme important in murein synthesis which transfers the N-acetylmuramoylpentapeptide to a membrane-bound carrier that is a C-55 terpene alcohol phosphate; minor descriptor (75-84); on-line & Index Medicus search PHOSPHOTRANSFERASES (75-84)
Summary Herpes simplex virus can confer to thymidine kinaseless cells the ability to incorporate exogenously supplied thymidine into acid precipitable material. However no incorporation of exogenously supplied deoxycytidine into acid precipitable material can be detected after infection of deoxycytidine kinaseless cells by herpes simplex virus. This failure to incorporate exogenous deoxycytidine is not due to the failure of the deoxycytidine phosphorylating activity of the virus induced deoxypyrimidine kinase but to a block in the metabolism of deoxycytidine monophosphate in herpes simplex virus infected cells. This block becomes evident with the appearance of the virus induced deoxypyrimidine kinase activity.
Thank you for your interest in spreading the word about Biochemical Journal.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Several hits in gapped BLAST to uridine kinase sequences, e.g. residues 4-206 are 41% similar to the enzyme from B.subtilis (Z99117). UU332 is similar to MG382 and, weakly, to TP0667, two predicted uridine kinases. No similarity to C.trachomatis ...
Kinase molecule, computer model. Kinases, also known as phosphotransferases, are enzymes that catalyse the transfer of phosphate groups from a high-energy phosphate-containing molecule (such as ATP or ADP) to a substrate (such as a protein, lipid or carbohydrate). This process is known as phosphorylation. The largest group of kinases are protein kinases. Up to 518 different types have been identified in humans and are used to transmit signals and control complex processes in cells. In this model the molecules shape (secondary structure) is seen, comprising alpha helices (coils), beta sheets (arrows) and linking regions (lines). - Stock Image A605/0207
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor.
Nucleoside-diphosphate kinases (Nme/Nm23/NDPK) constitute a family of evolutionary conserved enzymes involved in many crucial biological processes. The...
Glycerol uptake and glycerol kinase activity were studied in primary cultures of rat hepatocytes in the presence of either 1 nM insulin, 1 nM glucagon, or 100 nM dexamethasone, alone or in combination in
Thus, the two substrates of this enzyme are ATP and uridine, whereas its two products are ADP and UMP. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:uridine 5-phosphotransferase. Other names in common use include pyrimidine ribonucleoside kinase, uridine-cytidine kinase, uridine kinase (phosphorylating), and uridine phosphokinase. This enzyme participates in pyrimidine metabolism. ...
Protein target information for L-serine-phosphatidylethanolamine phosphatidyltransferase (roundworm). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
CDIPT (CDP-diacylglycerol--inositol 3-phosphatidyltransferase), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
The IUPHAR/BPS Guide to Pharmacology. phosphoinositide-3-kinase regulatory subunit 1 - Phosphatidylinositol kinases. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets.
TY - JOUR. T1 - The role of the actin cytoskeleton in the regulation of Na+ transport by phosphatidylinositol kinases in the frog skin. AU - Krutetskaya, Z. I.. AU - Lebedev, O. E.. AU - Melnitskaya, A. V.. AU - Nozdrachev, A. D.. PY - 2006/10/1. Y1 - 2006/10/1. UR - http://www.scopus.com/inward/record.url?scp=33750374692&partnerID=8YFLogxK. U2 - 10.1134/S001249660605005X. DO - 10.1134/S001249660605005X. M3 - Article. C2 - 17278836. AN - SCOPUS:33750374692. VL - 410. SP - 367. EP - 369. JO - Doklady Biological Sciences. JF - Doklady Biological Sciences. SN - 0012-4966. IS - 1. ER - ...
Journal of Amino Acids is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of amino acids.
GNPTG (N-acetylglucosamine-1-phosphate transferase subunit gamma), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
Ratliff, R.L., Weaver, R.H., Lardy, H.A. and Kuby, S.A. (1964). Nucleoside triphosphate-nucleoside diphosphate transphosphorylase (nucleoside diphosphokinase). I. Isolation of the crystalline enzyme from brewers yeast. J. Biol. Chem. 239: 301-309. PMID 14114857. ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Saint Girons, I.S., Gilles, A.-M., Margarita, D., Michelson, S., Monnot, M., Fermandjian, S., Danchin, A. and Barzu, O. (1987). „Structural and catalytic characteristics of Escherichia coli adenylate kinase. J. Biol. Chem. 262: 622-629. PMID 3027060 ...
This item is made to order and will take 10-12 business days to manufacture.Sales on this site ship only to the US and Canada. For other international orders, please email us at [email protected] SKU: XPEH1216 Category: Human ...
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found o
Adenylate Kinase 1兔多克隆抗体(ab71621)可与仓鼠, 人样本反应并经WB, ELISA, IHC实验严格验证。所有产品均提供质保服务,中国75%以上现货。
MTSQEKTEEYPFADIFDEDETERNFLLSKPVCFVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIA 1 - 70 AETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITEIPSLSQDAMTTLQQIELIKNLNLK 71 - 140 PDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEVIENHRKKKKEAQKDGKGEEEEEEEEQEEEE 141 - 210 AFIAEMQMVAEILHHLVQRPEDYLENVENIVKLYKETILQTLEEVMAEHNPQYLIELNGNKPAEELFMIV 211 - 280 MDRLKYLNLKRAAILTKLQGAEEEINDTMENDELFRTLASYKLIAPRYRWQRSKWGRTCPVNLKDGNIYS 281 - 350 GLPDYSVSFLGKIYCLSSEEALKPFLLNPRPYLLPPMPGPPCKVFILGPQYSGKTTLCNMLAENYKGKVV 351 - 420 DYAQLVQPRFDKARETLVENTIAEATAAAIKVVKEKLLRELQARKQAETALREFQRQYEKMEFGVFPMEA 421 - 490 THSSIDEEGYIQGSQRDRGSSLVDTEEAKTKSENVLHDQAAKVDKDDGKETGETFTFKRHSQDASQDVKL 491 - 560 YSDTAPTEDLIEEVTADHPEVVTMIEETIKMSQDINFEQPYEKHAEILQEVLGEVMEENKDRFPGAPKYG 561 - 630 GWIVDNCPIVKELWMALIKKGIIPDLVIYLSDTENNGKCLFNRIYLQKKSEIDSKILERLLEELQKKKKE 631 - 700 EEEARKATEEELRLEEENRRLLELMKVKAKEAEETDNEDEEEIEGDELEVHEEPEASHDTRGSWLPEEFE 701 - 770 ASEVPETEPEAVSEPIEETTVETEIPKGSKEGLEIEKLSETVVLPEFPEDSYPDVPEMEPFKEKIGSFII 771 - 840 ...
myokinase definition: adenylate kinase, a phosphotransferase chemical that catalyzes the interconversion of adenine nucleotides and plays a crucial role in mobile energy homeostasis.
Considerable differences in steady-state hexokinase specific activity were found in 16 N.C.I.B. strains of Klebsiella aerogenes grown in identical conditions in glucose-limited chemostats. Strains of N.C.I.B. 8258 had no detectable activity, but its glucose-phosphoenolpyruvate phosphotransferase specific activity and that of the other strains were closely similar, and it is concluded that this phosphotransferase activity regulates the overall utilization of glucose, in which hexokinase plays no essential role. The hexokinase activity was subject to regulation by the availability of phosphorus, but this did not affect the glucose phosphotransferase activity. tlactose-grown organisms (including strain N.C.I.B. 8258) had no glucose phosphotransferase activity, but more than adequate hexokinase activity to phosphorylate the intracellularly liberated glucose. ...
Definition of Phosphoglyceromutase with photos and pictures, translations, sample usage, and additional links for more information.
Overview Protocols Specifications Resources Convenient, Scalable Kinase Profiling The Kinase Enzyme Systems include a recombinant kinase enzyme, a substrate appropriate for the enzyme, a reaction buffer and supplemental reagents as needed. The TGF?R2 Kinase Enzyme System contains: TGF?R2 Kinase, 10ug (Human, recombinan
Overview Protocols Specifications Resources Convenient, Scalable Kinase Profiling The Kinase Enzyme Systems include a recombinant kinase enzyme, a substrate appropriate for the enzyme, a reaction buffer and supplemental reagents as needed. The p38? Kinase Enzyme System contains: p38? Kinase, 10ug (Human, recombinant fu
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are ...
Human (Homo sapiens) のGLYCTK (glycerate kinase)遺伝子を含むベクター、レンチウイルス、アデノウイルス、 (AAV) アデノ随伴、アデノ随伴ウイルス、MMLV レトロウイルス,、piggyBac, shRNA、gRNA、 ガイドRNA、 CRISPR-Cas9 、クリスパー、プラスミド
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the ...
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the ...
Choline kinase (also known as CK,ChoK and choline phosphokinase) is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis. This reaction involves the transfer of a phosphate group from adenosine triphosphate (ATP) to choline in order to form phosphocholine. ATP + choline ⇌ {\displaystyle \rightleftharpoons } ADP + O-phosphocholine Thus, the two substrates of this enzyme are ATP and choline, whereas its two products are adenosine diphosphate (ADP) and O-phosphocholine. Choline kinase requires magnesium ions (+2) as a cofactor for this reaction. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The first detailed investigation of the enzyme was conducted by McCamen in 1962, where it was shown that the brain is the richest source of the enzyme in mammalian tissue. A related enzyme, ethanolamine kinase, tends to co-purify ...
Order Adenylate Kinase 1 ELISA Kits for many Reactivities. Mouse and more. Compare Adenylate Kinase 1 ELISA Kits and find the right product on antibodies-online.com.
The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008 ...
Recombinant full-length human DGKQ was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Diacylglycerol kinase theta (DAG kinase theta) is the only member of class V diacylglycerol kinase.
Shop Lichenan-specific phosphotransferase enzyme IIA component ELISA Kit, Recombinant Protein and Lichenan-specific phosphotransferase enzyme IIA component Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Fingerprint Dive into the research topics of A Mitochondrial RNAi Screen Defines Cellular Bioenergetic Determinants and Identifies an Adenylate Kinase as a Key Regulator of ATP Levels. Together they form a unique fingerprint. ...
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1AKY: High-resolution structures of adenylate kinase from yeast ligated with inhibitor Ap5A, showing the pathway of phosphoryl transfer.
Activation and aggregation of blood platelets is crucial for hemostasis and thrombosis. In the vascular system adenine nucleotides are important signaling molecules playing a key role in hemostasis. ADP was the first low molecular weight agent recognized to cause blood platelets activation and aggregation. NTPDases and adenylate kinase (AK) are the main enzymes involved in metabolism of extracellular adenine nucleotides. The majority of studies concentrated on the role of NTPDase1 (apyrase) in the inhibition of platelets aggregation. Up to now, there are still insufficient data concerning the role of AK in this process. We found that adenylate kinase activity in the serum of patients with myocardial infarction is significantly increased when compared to the healthy volunteers. The elevated activity of AK is connected to appearance of another isoform of that enzyme, expressed in patients with myocardial infarction. The influence of AK on the pig blood platelets aggregation induced by 20 μM ADP or 7.5
The energy expenditure of another ATP in this step is justified in 2 ways: The glycolytic process (up to this step) is now irreversible, and the energy supplied destabilizes the molecule. Because the reaction catalyzed by Phosphofructokinase 1 (PFK-1) is coupled to the hydrolysis of ATP, an energetically favorable step, it is, in essence, irreversible, and a different pathway must be used to do the reverse conversion during gluconeogenesis. This makes the reaction a key regulatory point (see below). This is also the rate-limiting step. Furthermore, the second phosphorylation event is necessary to allow the formation of two charged groups (rather than only one) in the subsequent step of glycolysis, ensuring the prevention of free diffusion of substrates out of the cell. The same reaction can also be catalyzed by pyrophosphate-dependent phosphofructokinase (PFP or PPi-PFK), which is found in most plants, some bacteria, archea, and protists, but not in animals. This enzyme uses pyrophosphate (PPi) ...
The aminoglycoside phosphotransferases (APHs) are responsible for the bacterial inactivation of many clinically useful aminoglycoside antibiotics. We report the characterization of an enterococcal enzyme, APH(3)-IIIa, which inactivates a broad spectrum of aminoglycosides by ATP-dependent O-phosphorylation. Overproduction of APH(3)-IIIa has permitted the isolation of 30-40 mg of pure protein/(L of cell culture). Purified APH(3)-IIIa is a mixture of monomer and dimer which is slowly converted to dimer only over time. Dimer could be dissociated into monomer by incubation with 2-mercaptoethanol, suggesting that dimerization is mediated by formation of disulfide bond(s). Both monomer and dimer show Km values in the low micromolar range for good substrates such as kanamycin and neomycin, and kcat values of 1-4 s-1. All aminoglycosides show substrate inhibition except amikacin and kanamycin B. Determination of minimum inhibitory concentrations indicates a positive correlation between antibiotic activity and
The main aim of the work presented in this thesis was to elucidate the apparent role of pyrophosphate fructose 6-phosphate 1-phosphotransferase (PFP) in sucrose accumulation in sugarcane. PFP activity in sugarcane internodal tissue is inversely correlated to the sucrose content and positively to the water-insoluble component across varieties which differ in their capacities to accumulate sucrose. This apparent well defined and important role of PFP seems to stand in contrast to the ambiguity regarding PFPs role in the general literature as well as the results of various transgenic studies where neither the downregulation nor the over-expression of PFP activity had a major influence on the phenotype of transgenic potato and tobacco plants. Based on this it was therefore thought that either the kinetic properties of sugarcane PFP is significantly different than that of other plant PFPs or that PFPs role in sucrose accumulating tissues is different from that in starch accumulating tissues. In the ...
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, ...
The two-component system is involved in several developmental events and different responses to the environment. Histidine-containing phosphotransfer prote
AimsTo measure the activity of the key phosphotransfer enzymes creatine kinase (CK), adenylate kinase (AK), and glycolytic enzymes in two common mouse models of chronic heart failure.Methods and resultsC57BL/6 mice were subjected to transverse aortic constriction (TAC), myocardial infarction induced
1BIF: The crystal structure of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase reveals distinct domain homologies.
Kit Component:- KN302227G1, Bpgm gRNA vector 1 in pCas-Guide vector- KN302227G2, Bpgm gRNA vector 2 in pCas-Guide vector- KN302227D, donor vector…
Numerous significant hits using gapped BLAST to aspartokinase III from E. coli (416597), Arabidopsis thaliana (6091740, putative), Methanococcus jannaschii (2492982), among others. HD1375 is 57% similar to residues 1-449 from AK3_ECOLI ...
Similar to Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 3 (Dictyostelium discoideum) (uniprot_sprot:sp,Q550W1,CAPTC_DICDI ...
Recombinant human EGFR (d746) (amino acids 695-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity.
tRNA 2-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1-2cyclic phosphate and ...
Phosphoinositide 3-kinase enzymes are a group of intracellular signal transducers that phosphorylate the 3-hydroxyl group of phosphatidylinositol
Find out all of the information about the Seldén Mast AB product: plain bearing block 406-001-18. Contact a supplier or the parent company directly to get a quote or to find out a price or your closest point of sale.
Aminoglycoside-3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an enzyme that primarily catalyzes the ... The systematic name of this enzyme class is ATP:kanamycin 3'-O-phosphotransferase. This enzyme is also called neomycin- ... Fong, DH, Berghuis, AM (2002). "Crystal Structure Of 3',5"-Aminoglycoside Phosphotransferase Type IIIa ADP Kanamycin A Complex ... McKay, GA, Thompson, PR, Wright, GD (1994). "Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: ...
There is a mitochondrial GTP:AMP phosphotransferase, also specific for the phosphorylation of AMP, that can only use GTP or ITP ... Adenylate kinase (EC 2.7.4.3) (also known as ADK or myokinase) is a phosphotransferase enzyme that catalyzes the ... Tomasselli AG, Noda LH (January 1979). "Mitochondrial GTP-AMP phosphotransferase. 2. Kinetic and equilibrium dialysis studies ...
The systematic name of this enzyme class is ATP:ammonia phosphotransferase. Other names in common use include phosphoramidate- ... adenosine diphosphate phosphotransferase, and phosphoramidate-ADP-phosphotransferase. Dowler MJ, Nakada HI (1968). "Yeast ... phosphoramidate-adenosine diphosphate phosphotransferase". J. Biol. Chem. 243 (7): 1434-40. PMID 5647264. Biology portal v t e ... phosphotransferases) with a nitrogenous group as acceptor. ...
... s are part of the larger family of phosphotransferases. Kinases should not be confused with phosphorylases, which ... kinase Phosphatase Phosphatidylinositol phosphate kinases Phospholipid Phosphoprotein Phosphorylation Phosphotransferase Signal ...
Their designated EC number is 2.7.9. It is one of the smallest groups of phosphotransferases. Dikinases take two phosphate ... Dikinases should not be confused with diphosphotransferases (EC 2.7.6), which are phosphotransferases which act upon ...
The systematic name of this enzyme class is ATP:guanidinoacetate N-phosphotransferase. This enzyme is also called glycocyamine ... Pradel LA, Kassab R, Thoai NV (1964). "Sur l'acide adenosine-triphosphorique:guanidoacetate phosphotransferase". Biochim. ... guanidinoacetate phosphotransferase]". Biochim. Biophys. Acta. 154 (2): 305-14. doi:10.1016/0005-2795(68)90044-5. PMID 5637051 ... phosphotransferases) with a nitrogenous group as acceptor. ...
Erni, B.; Zanolari, B. (1985). "The mannose-permease of the bacterial phosphotransferase system. Gene cloning and purification ... Postma, P. W.; Lengeler, J. W.; Jacobson, G. R. (1993). "Phosphoenolpyruvate:carbohydrate phosphotransferase systems of ... "Structure of the mannose transporter of the bacterial phosphotransferase system". Cell Research. 29 (8): 680-682. doi:10.1038/ ... Play media The PEP-dependent sugar transporting phosphotransferase system transports and simultaneously phosphorylates its ...
Meadow ND, Fox DK, Roseman S (1990). "The bacterial phosphoenolpyruvate: glycose phosphotransferase system". Annu. Rev. Biochem ... Postma PW, Lengeler JW, Jacobson GR (1993). "Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria". ... The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) is a major carbohydrate transport system in bacteria. ... HPr protein is a small cytoplasmic protein that is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase ...
Reeves, R. E.; South D. J.; Blytt H. J.; Warren L. G. (1974). "Pyrophosphate: D-fructose 6-phosphate 1-phosphotransferase. A ... new enzyme with the glycolytic function 6-phosphate 1-phosphotransferase". J Biol Chem. 249 (24): 7737-7741. PMID 4372217. ...
The systematic name of this enzyme class is ATP:choline phosphotransferase. These enzymes participate in glycine, serine and ... McKay GA, Wright GD (October 1995). "Kinetic mechanism of aminoglycoside phosphotransferase type IIIa. Evidence for a Theorell- ... phosphotransferases) with an alcohol group as acceptor. The first detailed investigation of the enzyme was conducted by McCamen ... an aminoglycoside phosphotransferase and CK.[citation needed] Propositions for this mechanism have been made based on ...
"The complete phosphotransferase system in Escherichia coli". Journal of Molecular Microbiology and Biotechnology. 3 (3): 329-46 ...
The phosphotransferase enzyme can likewise activate valganciclovir. Roche's Valcyte is protected by patent. However a generic ...
With the glucose phosphotransferase system, the phosphorylation status of EIIA can have regulatory functions. For example, at ... The phosphotransferase system is involved in transporting many sugars into bacteria, including glucose, mannose, fructose and ... Phosphoenolpyruvate+Sugar+Phosphotransferase+System at the US National Library of Medicine Medical Subject Headings (MeSH). ... PEP group translocation, also known as the phosphotransferase system or PTS, is a distinct method used by bacteria for sugar ...
Tchieu, J. H.; Norris, V.; Edwards, J. S.; Saier, M. H. (2001-07-01). "The complete phosphotransferase system in Escherichia ... Reizer, Jonathan (Apr 1995). "Novel phosphotransferase system genes revealed by bacterial genome analysis--a gene cluster ...
... and pyrophosphate-fructose 6-phosphate 1-phosphotransferase, pyrophosphate-fructose 6-phosphate phosphotransferase PFK PDB: ... The systematic name of this enzyme class is diphosphate:D-fructose-6-phosphate 1-phosphotransferase. Other names in common use ... Diphosphate-fructose-6-phosphate 1-phosphotransferase also known as PFP is an enzyme of carbohydrate metabolism in plants and ... Reeves RE, South DJ, Blytt HJ, Warren LG (December 1974). "Pyrophosphate:D-fructose 6-phosphate 1-phosphotransferase. A new ...
The systematic name of this enzyme class is AMP:thymidine 5'-phosphotransferase. This enzyme is also called adenylate- ... Falke D, Labenz J, Brauer D, Muller WE (1982). "Adenosine diphosphate: thymidine 5'-phosphotransferase, a new enzyme activity, ... Falke D, Nehrbass W, Brauer D, Muller WE (1981). "Adenylic acid: deoxythymidine 5'-phosphotransferase: evidence for the ... phosphotransferases) with an alcohol group as acceptor. ...
The systematic name of this enzyme class is diphosphate:acetate phosphotransferase. This enzyme is also called pyrophosphate- ... acetate phosphotransferase. This enzyme participates in pyruvate metabolism. Reeves RE, Guthrie JD (1975). "Acetate kinase ( ... phosphotransferases) with a carboxy group as acceptor. ...
FUJIMOTO A, INGRAM P, SMITH RA (1965). "D-GLUCOSE-I-PHOSPHATE:D-GLUCOSE-6-PHOSPHOTRANSFERASE". Biochim. Biophys. Acta. 96: 91- ... This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer ... and glucose-1-phosphate phosphotransferase. This enzyme has at least one effector, D-Glucose. ...
The Zeta Toxin is folded like a phosphotransferase. This domain features an α/β structure and the central twisted β-sheet ...
The systematic name of this enzyme class is ATP:hygromycin-B 7"-O-phosphotransferase. This enzyme is also called hygromycin B ... Zalacain M, Pardo JM, Jimenez A (1987). "Purification and characterization of a hygromycin B phosphotransferase from ... phosphotransferases) with an alcohol group as acceptor. ...
The systematic name of this enzyme class is ATP:lombricine N-phosphotransferase. This enzyme participates in glycine, serine ... Kassab R; Pradel LA; Nguyen Van Thoai (1965). "[ATP:taurocyamine and ATP:lombricine phosphotransferases Purification and study ... "The purification and properties of adenosine triphosphate-lombricine phosphotransferase". Biochem. J. 90 (1): 170-6. PMC ... phosphotransferases) with a nitrogenous group as acceptor. ...
Other names in common use include taurocyamine phosphotransferase, and ATP:taurocyamine phosphotransferase. This enzyme ... Kassab R, Pradel LA, Nguyen VT (1965). "[ATP:taurocyamine and ATP:lombricine phosphotransferases Purification and study of SH ... The systematic name of this enzyme class is ATP:taurocyamine N-phosphotransferase. ... phosphotransferases) with a nitrogenous group as acceptor. ...
Advances in Phosphotransferases (Phosphate Group Acceptor) Research and Application: 2013 Edition: ScholarlyPaper. ...
... phosphotransferase system (PTS) proteins". Philosophical Transactions of the Royal Society of London. Series B, Biological ...
I. Isolation of a phosphotransferase system from Escherichia coli. J Biol Chem 246:1393-1406. Book of Members 1780-Present (PDF ... Among many discoveries related to carbohydrate biochemistry, he discovered the phosphotransferase system in bacteria. 1971 ...
... are phosphotransferase enzymes which act upon pyrophosphate groups. They are classified under EC number ...
... a member of the ASKHA superfamily of phosphotransferases". Journal of Bacteriology. 183 (2): 680-686. doi:10.1128/JB.183.2.680- ...
The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the ... Collet JF, Stroobant V, Pirard M, Delpierre G, Van Schaftingen E (Jun 1998). "A new class of phosphotransferases phosphorylated ...
Bacteriocin uses components of the mannose phosphotransferase system (man-PTS) of susceptible cells as target/receptor. The ... Kjos M, Nes IF, Diep DB (2011). "Mechanisms of resistance to bacteriocins targeting the mannose phosphotransferase system". ... "Structure of the mannose transporter of the bacterial phosphotransferase system". Cell Research. 29 (8): 680-682. doi:10.1038/ ...
"Structure of the mannose transporter of the bacterial phosphotransferase system". Cell Research. 29 (8): 680-682. doi:10.1038/ ...
EC 2.7.1 Phosphotransferases with an alcohol group as acceptor EC 2.7.2 Phosphotransferases with a carboxy group as acceptor EC ... Phosphotransferases are a category of enzymes (EC number 2.7) that catalyze phosphorylation reactions. The general form of the ... The phosphotransferase system (PTS) is a complex group translocation system present in many bacteria. The PTS transports sugars ... The first step of this reaction is phosphorylation of the substrate via phosphotransferase during transport. In the case of ...
Other names in common use include yeast 2-phosphotransferase, Tpt1, Tpt1p, and 2-phospho-tRNA:NAD+ phosphotransferase. ... In enzymology, a 2-phosphotransferase (EC 2.7.1.160) is an enzyme that catalyzes the chemical reaction 2-phospho-[ligated ... Steiger MA, Kierzek R, Turner DH, Phizicky EM (2001). "Substrate recognition by a yeast 2-phosphotransferase involved in tRNA ... Culver GM, McCraith SM, Consaul SA, Stanford DR, Phizicky EM (1997). "A 2-phosphotransferase implicated in tRNA splicing is ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
Phosphotransferase KptA/Tpt1 (IPR002745). Short name: Ptrans_KptA/Tpt1 Family relationships *Phosphotransferase KptA/Tpt1 ( ... Substrate recognition by a yeast 2-phosphotransferase involved in tRNA splicing and by its Escherichia coli homolog.. ... The final step of tRNA splicing in Saccharomyces cerevisiae (Bakers yeast) requires 2-phosphotransferase (Tpt1) to transfer ...
Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions.. Sigal YJ1, McDermott MI, ... Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions. Biochem J. 2005 Apr 15;387(Pt ... Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions. Biochem J. 2005 Apr 15;387(Pt ... Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions. Biochem J. 2005 Apr 15;387(Pt ...
Glucose-ATP Phosphotransferases During Hepatocarcinogenesis. Rajani Manjeshwar Sharma, Chakravarthi Sharma, Andrew J. Donnelly ... Glucose-ATP Phosphotransferases During Hepatocarcinogenesis. Rajani Manjeshwar Sharma, Chakravarthi Sharma, Andrew J. Donnelly ... Glucose-ATP Phosphotransferases During Hepatocarcinogenesis. Rajani Manjeshwar Sharma, Chakravarthi Sharma, Andrew J. Donnelly ... Glucose-ATP Phosphotransferases During Hepatocarcinogenesis Message Subject (Your Name) has forwarded a page to you from Cancer ...
... Paola R. Beassoni, Lucas A. ... ADP Phosphotransferase," Enzyme Research, vol. 2015, Article ID 404607, 13 pages, 2015. https://doi.org/10.1155/2015/404607. ...
PhosphotransferaseUniRule annotation. ,p>Information which has been generated by the UniProtKB automatic annotation system, ... tr,Q64596,Q64596_RAT Phosphotransferase OS=Rattus norvegicus GN=Gck PE=1 SV=1 ...
Phosphotransferase system (PTS) + T30020 [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show description , ... The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of ...
Phosphotransferase system (PTS) - Streptococcus parauberis [ Pathway menu , Organism menu , Pathway entry , Download KGML , ... The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of ...
In Vitro ATP Regeneration from Polyphosphate and AMP by Polyphosphate:AMP Phosphotransferase and Adenylate Kinase from ...
Compare N-acetylglucosamine-1-phosphotransferase, gamma subunit Biomolecules from leading suppliers on Biocompare. View ... Your search returned 5 N-acetylglucosamine-1-phosphotransferase, gamma subunit Biomolecules across 4 suppliers. ...
Compare aminoglycoside phosphotransferase domain containing 1 ELISA Kits from leading suppliers on Biocompare. View ... aminoglycoside phosphotransferase domain containing 1 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a widely ... Your search returned 18 aminoglycoside phosphotransferase domain containing 1 ELISA ELISA Kit across 1 supplier. ...
Nucleotide sequence of a streptomycete aminoglycoside phosphotransferase gene and its relationship to phosphotransferases ... Nucleotide sequence of a streptomycete aminoglycoside phosphotransferase gene and its relationship to phosphotransferases ... Nucleotide sequence of a streptomycete aminoglycoside phosphotransferase gene and its relationship to phosphotransferases ... Nucleotide sequence of a streptomycete aminoglycoside phosphotransferase gene and its relationship to phosphotransferases ...
Phosphoenolpyruvate Sugar Phosphotransferase System/genetics. *Phosphoenolpyruvate Sugar Phosphotransferase System/metabolism* ... The phosphoenolpyruvate:sugar phosphotransferase system is involved in sensitivity to the glucosylated bacteriocin sublancin.. ... The Phosphoenolpyruvate:Sugar Phosphotransferase System Is Involved in Sensitivity to the Glucosylated Bacteriocin Sublancin ... The Phosphoenolpyruvate:Sugar Phosphotransferase System Is Involved in Sensitivity to the Glucosylated Bacteriocin Sublancin ...
In addition, PhyT acts as a phosphotransferase in a GSR activating phosphorelay. Our data suggest a model according to which ... The phosphoryl group of SdrG is then transferred by the phosphotransferase PhyT to the master regulator of the general stress ...
Scientific Experts about Experts and Doctors on phosphotransferases in Philadelphia, Pennsylvania, United States ... You are here: Locale , United States , Pennsylvania , Experts and Doctors on phosphotransferases in Philadelphia, Pennsylvania ... Experts and Doctors on phosphotransferases in Philadelphia, Pennsylvania, United States. Summary. Locale: Philadelphia, ...
choline-ethanolamine phosphotransferase activity. Introduction. Membrane phospholipids have a dual role as structural building ... This effect of NMDA is produced by a reduction of choline-ethanolamine phosphotransferase activity. Because PtdCho and PtdEtn ... NMDA Receptor Overactivation Inhibits Phospholipid Synthesis by Decreasing Choline-Ethanolamine Phosphotransferase Activity. ... NMDA Receptor Overactivation Inhibits Phospholipid Synthesis by Decreasing Choline-Ethanolamine Phosphotransferase Activity ...
Crystal Structure of Aminoglycoside-2-Phosphotransferase Type IVa in Complex with Guanosine. *DOI: 10.2210/pdb4DT9/pdb ... Enzymatic phosphorylation through a family of enzymes called aminoglycoside O-phosphotransferases (APHs) is a major mechanism ... Enzymatic phosphorylation through a family of enzymes called aminoglycoside O-phosphotransferases (APHs) is a major mechanism ... Structural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2-Phosphotransferase IVa Provides Insight on Determinants ...
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, ...
Urkinase: Structure of Acetate Kinase, a Member of the ASKHA Superfamily of Phosphotransferases. Kathryn A. Buss, David R. ... 1986) Phosphate transfer between acetate kinase and enzyme I of the bacterial phosphotransferase system. J. Biol. Chem. 261: ... However, a movement of the loop of approximately 3 Å, similar to those observed in the other ASKHA phosphotransferases, would ... Two components of the interaction between the protein and the nucleotide that are observed in other ASKHA phosphotransferases ...
Urkinase: Structure of Acetate Kinase, a Member of the ASKHA Superfamily of Phosphotransferases. Kathryn A. Buss, David R. ... Urkinase: Structure of Acetate Kinase, a Member of the ASKHA Superfamily of Phosphotransferases ... Urkinase: Structure of Acetate Kinase, a Member of the ASKHA Superfamily of Phosphotransferases ... Urkinase: Structure of Acetate Kinase, a Member of the ASKHA Superfamily of Phosphotransferases ...
More product categories related to Choline Phosphotransferase 1 ELISA Kit * 35 anti-Choline Phosphotransferase 1 Primary ... More ELISA Kits for Choline Phosphotransferase 1 Interaction Partners. Human Choline Phosphotransferase 1 (CHPT1) interaction ... Additionally we are shipping Choline Phosphotransferase 1 Antibodies (35) and Choline Phosphotransferase 1 Proteins (2) and ... Top Choline Phosphotransferase 1 ELISA Kits at antibodies-online.com. Showing 5 out of 8 products:. Catalog No.. Reactivity. ...
San, Ka-Yiu, Bennett, George N., Causey, Thomas Bryce, Wong, Matthew Sing and Wu, Steven, "Reduced phosphotransferase system ...
Regulated high-level expression of the mannitol permease of the phosphoenolpyruvate-dependent sugar phosphotransferase system ... Regulated high-level expression of the mannitol permease of the phosphoenolpyruvate-dependent sugar phosphotransferase system ... Regulated high-level expression of the mannitol permease of the phosphoenolpyruvate-dependent sugar phosphotransferase system ... Regulated high-level expression of the mannitol permease of the phosphoenolpyruvate-dependent sugar phosphotransferase system ...
PDRP is an unusual bifunctional ADP-dependent phosphotransferase involved in the regulation of C4 plant photosynthesis. Despite ...
Figure 7: Dependence of the steady state HPr phosphorylation rate on the PEP and Pyr concentrations (contour maps) calculated by the Model II. (a) total stationary rate of HPr phosphorylation. Also shown contributions (to the total HPr phosphorylation rate) of rates of the HPr phosphorylation: (b) by the monomer; (c) by the doubly phosphorylated dimer; (d) by the singly phosphorylated dimmer Concentrations of the enzymes are close to physiological ones (taken from [25]), which are: EI = 5 μM, HPr = 40 μM ...
Bacteria evolved a unique mechanism to import many carbohydrates, the phosphoenolpyruvate:sugar phosphotransferase system (PTS ... Structure of the full-length enzyme I of the phosphoenolpyruvate-dependent sugar phosphotransferase system. J. Biol. Chem. 27, ... sugar phosphotransferase system. Proc. Natl. Acad. Sci. USA 103, 16218-16223. ... Retrieved from "http://proteopedia.org/wiki/index.php/Enzyme_I_of_the_Phosphoenolpyruvate:Sugar_Phosphotransferase_System" ...
Phosphotransferase system (PTS) - Roseobacter ponti [ Pathway menu , Pathway entry , Download KGML , Show description , Image ( ... The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of ...
  • The phosphoenolpyruvate:sugar phosphotransferase system is involved in sensitivity to the glucosylated bacteriocin sublancin. (nih.gov)
  • In the current study of one glycocin, sublancin, we identified the phosphoenolpyruvate:sugar phosphotransferase system (PTS) of Bacillus species as a key player in bacterial sensitivity. (nih.gov)
  • The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS ), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. (rcsb.org)
  • Bacteria evolved a unique mechanism to import many carbohydrates, the phosphoenolpyruvate:sugar phosphotransferase system (PTS). (proteopedia.org)
  • Signaling sugar translocation: Structure of phosphorylated Enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system. (proteopedia.org)
  • Structure of the full-length enzyme I of the phosphoenolpyruvate-dependent sugar phosphotransferase system. (proteopedia.org)
  • In 1964, Kundig, Ghosh and Roseman reported the discovery of the phosphoenolpyruvate:sugar phosphotransferase system (PTS), which they subsequently proposed might catalyze sugar transport as well as sugar phosphorylation. (pubmedcentralcanada.ca)
  • Protein phosphorylation and allosteric control of inducer exclusion and catabolite repression by the bacterial phosphoenolpyruvate: sugar phosphotransferase system. (asm.org)
  • Background: The major uptake system responsible for the transport of fructose, glucose, and sucrose in Corynebacterium glutamicum ATCC 13032 is the phosphoenolpyruvate:sugar phosphotransferase system (PTS). (uni-bielefeld.de)
  • Phosphoenolpyruvate Sugar Phosphotransferase System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to its sugar substrates (the PTS sugars) concomitant with the translocation of these sugars across the bacterial membrane. (uchicago.edu)
  • Below are the most recent publications written about "Phosphoenolpyruvate Sugar Phosphotransferase System" by people in Profiles. (uchicago.edu)
  • We report a procedure for the isolation of IIIglc of Salmonella typhimurium, a protein component of the phosphoenolpyruvate-dependent sugar phosphotransferase system. (core.ac.uk)
  • The ptsH, ptsI , and crr genes of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system, a complex operon with several modes of transcription. (microbiologyresearch.org)
  • The phosphotransferase system (PTS) in Escherichia coli is a multifunctional, multicomponent enzyme system. (docphin.com)
  • The phosphotransferase system (PTS) is a complex group translocation system present in many bacteria. (wikipedia.org)
  • The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. (genome.jp)
  • SUMMARY We report analyses of 202 fully sequenced genomes for homologues of known protein constituents of the bacterial phosphoenolpyruvate-dependent phosphotransferase system (PTS). (asm.org)
  • The unique features of this phosphotransferase system (PTS) included the use of phosphoenolpyruvate (PEP) as the phosphoryl donor for sugar phosphorylation and the presence of three essential catalytic entities, termed Enzyme I, Enzyme II and HPr (heat-stable, histidinephosphorylatable protein). (pubmedcentralcanada.ca)
  • The membrane proteins IIC and IID of the mannose phosphotransferase system (Man-PTS) together form a membrane-located complex that serves as a receptor for several different bacteriocins, including the pediocin-like class IIa bacteriocins and the class IIc bacteriocin lactococcin A. Bacterial strains sensitive to class IIa bacteriocins readily give rise to resistant mutants upon bacteriocin exposure. (asm.org)
  • Furthermore, it has been shown in recent years that a set of bacteriocins produced by both Gram-positive and Gram-negative species can employ the membrane components of the mannose phosphotransferase system (Man-PTS) on sensitive cells as receptor molecules. (asm.org)
  • Quantification of the regulation of glycerol and maltose metabolism by IIAglc of the phosphoenolpyruvate-dependent glucose phosphotransferase system in Salmonella typhimurium. (uva.nl)
  • Although factors promoting E. faecalis colonization of intestines are not fully known, one implicated pathway is a phosphotransferase system (PTS) in E. faecalis strain OG1RF that phosphorylates gluconate and contains the genes OG1RF_12399 to OG1RF_12402 (OG1RF_12399-12402). (asm.org)
  • The bacterial phosphotransferase system (PTS) functions in a variety of regulatory capacities. (asm.org)
  • This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). (creative-enzymes.com)
  • Genetic studies revealed that these mutants had defective ptsI or ptsH genes responsible for the synthesis of common components of the phosphoenolpyruvate-dependent phosphotransferase system, enzyme I and the HPr protein, respectively. (deepdyve.com)
  • The phosphotransferase system (PTS) couples the import of carbohydrates with their phosphorylation prior to metabolism and has been linked to GAS pathogenesis. (asm.org)
  • Signal transduction by the bacterial phosphotransferase system. (semanticscholar.org)
  • Unique regulation of carbohydrate chemotaxis in Bacillus subtilis by the phosphoenolpyruvate-dependent phosphotransferase system and the methyl-accepting chemotaxis protein McpC. (semanticscholar.org)
  • Also known as Lichenan-specific phosphotransferase enzyme IIA component (EIIA-Lic) (EIII-Lic) (PTS system lichenan-specific EIIA component). (mybiosource.com)
  • The proteins encoded by the fructose-inducible lev operon of Bacillus subtilis are components of a phosphotransferase system. (pasteur.fr)
  • The two soluble proteins from together with the general proteins of the phosphotransferase system, enzyme I and HPr, a protein phosphorylation chain which serves to phosphorylate fructose transported by LevF and LevG. (pasteur.fr)
  • The phosphoenolpyruvate : carbohydrate phosphotransferase system (PTS) catalyses the transport of carbohydrates by coupling carbohydrate translocation and phosphorylation. (microbiologyresearch.org)
  • How phosphotransferase system-related protein phosphorylation regulates carbohydrate metabolism in bacteria. (microbiologyresearch.org)
  • The Gram-positive Corynebacterium glutamicum co-metabolizes most carbon sources such as the phosphotransferase system (PTS) sugar glucose and the non-PTS sugar maltose. (microbiologyresearch.org)
  • Catalytic activities associated with the enzymes II of the bacterial phosphotransferase system. (docphin.com)
  • We took advantage of a general property of the phosphoenolpyruvate-dependent phosphotransferase system (PTS), in particular the mannose PTS. (microbiologyresearch.org)
  • Regulation of the phosphotransferase system (PTS)mediated sugar uptake in Corynebacterium glutamicum in response to perturbations of the central metabolism Inaugural - Dissertation zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultät der Universität zu Köln vorgelegt von Dimitar Plamenov Petrov aus Sofia, Bulgarien Köln, 2015 Diese Arbeit wurde am Institut für Biochemie der Universität zu Köln unter Anleitung von Herrn Professor Dr. R. Krämer durchgeführt. (studyres.com)
  • The uptake and concomitant phosphorylation of those two substrates is mediated by the phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS), consisting of the common proteins HPr and EI, and an array of substrate-specific EII permeases. (studyres.com)
  • The Small Protein SgrT Controls Transport Activity of the Glucose-Specific Phosphotransferase System. (uchicago.edu)
  • Wang, "Cellobiose-specific phosphotransferase system of Klebsiella pneumoniae and its importance in biofilm formation and virulence," Infection and Immunity, vol. (thefreedictionary.com)
  • EIIA Ntr is a member of a truncated phosphotransferase (PTS) system that serves regulatory functions and exists in many Proteobacteria in addition to the sugar transport PTS. (microbiologyresearch.org)
  • Insight into bacterial phosphotransferase system-mediated signaling by interspecies transplantation of a transcriptional regulator. (microbiologyresearch.org)
  • Regulatory tasks of the phosphoenolpyruvate-phosphotransferase system of Pseudomonas putida in central carbon metabolism. (microbiologyresearch.org)
  • Mitchell, WJ & Tangney, M 2005, Carbohydrate uptake by the phosphotransferase system and other mechanisms . (hw.ac.uk)
  • Isolation of IIIGlc of the phosphoenolpyruvate-dependent glucose phosphotransferase system of Salmonella typhimurium. (core.ac.uk)
  • A phosphoenolpyruvate:mannose phosphotransferase system (mannose-PTS) was found to be involved in glucose and mannose transport in Lactobacillus curvatus. (readabstracts.com)
  • Phosphotransferases are generally classified according to the acceptor molecule. (wikipedia.org)
  • EC 2.7.1 Phosphotransferases with an alcohol group as acceptor EC 2.7.2 Phosphotransferases with a carboxy group as acceptor EC 2.7.3 Phosphotransferases with a nitrogenous group as acceptor EC 2.7.4 Phosphotransferases with a phosphate group as acceptor EC 2.7.9 Phosphotransferases with paired acceptors. (wikipedia.org)
  • This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. (wikipedia.org)
  • Phosphotransferases (Alcohol Group Acceptor)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (sickkids.ca)
  • This graph shows the total number of publications written about "Phosphotransferases (Alcohol Group Acceptor)" by people in this website by year, and whether "Phosphotransferases (Alcohol Group Acceptor)" was a major or minor topic of these publications. (sickkids.ca)
  • Below are the most recent publications written about "Phosphotransferases (Alcohol Group Acceptor)" by people in Profiles. (sickkids.ca)
  • This enzyme belongs to the family of transferases , specifically those transferring phosphorus-containing groups ( phosphotransferases ) with a phosphate group as acceptor. (wikidoc.org)
  • The DNA sequence of an aminoglycoside phosphotransferase gene (aph) from Streptomyces fradiae ATCC 10745 (a neomycin producer) was determined. (pnas.org)
  • We sequenced an aminoglycoside 3'-phosphotransferase gene (aph) from Streptomyces rimosus. (nih.gov)
  • A splicing mutation in the alpha/beta GlcNAc-1-phosphotransferase gene results in an adult onset form of mucolipidosis III associated with sensory neuropathy and cardiomyopathy. (unboundmedicine.com)
  • Sequence analysis of the patient's genomic DNA revealed a homozygous mutation of the last nucleotide of the 135-bp exon 7 of the phosphotransferase gene encoding the alpha/beta subunits, resulting in aberrant splicing and skipping of this exon. (unboundmedicine.com)
  • Beck E, Ludwig G, Auerswald EA, Reiss B, Schaller H (1982) Nucleotide sequence and exact localization of the neomycin phosphotransferase gene from transposon Tn 5 . (springer.com)
  • 9 We have previously ascribed ML III type C to mutations in the UDP -N- acetylglucosamine-1-phosphotransferase gamma subunit gene (GNPTAG) on chromosome 16p. (bmj.com)
  • We suggest that, although the exact relative frequency of each ML III type is not known, the UDP -N- acetylglucosamine-1-phosphotransferase gamma subunit gene apparently plays a major role in mucolipidosis type III. (bmj.com)
  • Neomycin phosphotransferase II (neo) is a selectable marker gene used extensively in plant transformation experiments. (semanticscholar.org)
  • 2005), they immortalised cynomolgus monkey oviduct cells using pSV3-neoplasmid (American Type Culture Collection, Manassas VA, USA) that contains both large and small T-antigens of the early region of SV40, and the bacterial neomycin phosphotransferase gene, which confers resistance to the antibiotic geneticin. (thefreedictionary.com)
  • TRPT1 (TRNA Phosphotransferase 1) is a Protein Coding gene. (genecards.org)
  • Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and tRNA 2'-phosphotransferase activity . (genecards.org)
  • The azithromycin resistance conferred by phosphotransferase is encoded in the gene mph(A). This gene has been discovered in and reported for many bacterial species. (elsevier.com)
  • PDRP is an unusual bifunctional ADP-dependent phosphotransferase involved in the regulation of C4 plant photosynthesis. (bl.uk)
  • The hexokinase activity was subject to regulation by the availability of phosphorus, but this did not affect the glucose phosphotransferase activity. (biochemj.org)
  • Cross-talk between posttranscriptionally silenced neomycin phosphotransferase II transgenes. (semanticscholar.org)
  • A sensitive and simple assay for neomycin phosphotransferase II activity in transgenic tissue. (semanticscholar.org)
  • A new assay for the detection of the enzyme neomycin phosphotransferase II (NPTII) in crude cell extracts is described. (semanticscholar.org)
  • The main aim of the work presented in this thesis was to elucidate the apparent role of pyrophosphate fructose 6-phosphate 1-phosphotransferase (PFP) in sucrose accumulation in sugarcane. (sun.ac.za)
  • Below are the list of possible Lichenan-specific phosphotransferase enzyme IIA component products. (mybiosource.com)
  • The phosphate donor, which is shared among the different systems, is usually a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate-protein phosphotransferase). (creative-enzymes.com)
  • Phosphotransferases are a category of enzymes (EC number 2.7) that catalyze phosphorylation reactions. (wikipedia.org)
  • The first step of this reaction is phosphorylation of the substrate via phosphotransferase during transport. (wikipedia.org)
  • Enzymatic phosphorylation through a family of enzymes called aminoglycoside O-phosphotransferases (APHs) is a major mechanism by which bacteria confer resistance to aminoglycoside antibiotics. (rcsb.org)
  • Complete sucrose metabolism requires fructose phosphotransferase activity in Corynebacterium glutamicum to ensure phosphorylation of liberated fructose. (microbiologyresearch.org)
  • These five groups of homologous proteins, which we collectively term LPTs (lipid phosphatases/phosphotransferases), are characterized by a core domain containing six transmembrane-spanning alpha-helices connected by extramembrane loops, two of which interact to form the catalytic site. (nih.gov)
  • These two groups include proteins that lack critical amino acids within the catalytic site, and could therefore not use the conserved LPT reaction mechanism to catalyse lipid phosphatase or phosphotransferase reactions. (nih.gov)
  • Additionally we are shipping Choline Phosphotransferase 1 Antibodies (35) and Choline Phosphotransferase 1 Proteins (2) and many more products for this protein. (antibodies-online.com)
  • The phosphotransferase must specifically recognize and phosphorylate soluble lysosomal proteins, which represent only a minority of all soluble glycoproteins passing through the Golgi apparatus. (embopress.org)
  • Aminoglycoside O -phosphotransferase (APH) enzymes transfer a phosphate group from ATP or GTP in the presence of Mg 2+ to a hydroxyl group on the aminoglycoside, yielding O -phosphoaminoglycoside and ADP or GDP. (asm.org)
  • Aminoglycoside acetyl transferase AAC 3-IV and hygromycin B4-1 phosphotransferase (hphB) in bacteria isolated from human and animal sources. (thefreedictionary.com)
  • The aminoglycoside phosphotransferases (APHs) are widely distributed among pathogenic bacteria and are employed to covalently modify, and thereby detoxify, the clinically relevant aminoglycoside antibiotics. (mcmaster.ca)
  • The aminoglycoside phosphotransferases (APHs) are responsible for the bacterial inactivation of many clinically useful aminoglycoside antibiotics. (umassmed.edu)
  • The final step of tRNA splicing in Saccharomyces cerevisiae (Baker's yeast) requires 2'-phosphotransferase (Tpt1) to transfer the 2'-phosphate from ligated tRNA to NAD, producing mature tRNA and ADP ribose-1' '-2' '-cyclic phosphate. (ebi.ac.uk)
  • Your search returned 5 N-acetylglucosamine-1-phosphotransferase, gamma subunit Biomolecules across 4 suppliers. (biocompare.com)
  • tlactose-grown organisms (including strain N.C.I.B. 8258) had no glucose phosphotransferase activity, but more than adequate hexokinase activity to phosphorylate the intracellularly liberated glucose. (biochemj.org)
  • Protein alignments also showed that FITM sequences contain the active site of lipid phosphatase/phosphotransferase (LPT) enzymes. (microbialcell.com)
  • Lobsters with ESD also show decreased expression in thoracic muscle of arginine kinase, a phosphotransferase involved in energy metabolism that could be indicative of an energetic drain in lobster muscle in diseased lobsters (Tarrant et al. (thefreedictionary.com)
  • The initial step is accomplished by the Golgi‐resident enzyme UDP‐ N ‐acetylglucosamine 1‐phosphotransferase (phosphotransferase), which catalyzes the transfer of GlcNAc phosphate onto the α‐1,2‐linked mannose residues in the oligosaccharide chains of lysosomal enzymes. (embopress.org)
  • Relative promoter strengths can be determined by gradient plate assays of kanamycin resistance, by measuring the amount of aminoglycoside phosphotransferase produced or by estimating neo mRNA synthesised. (springer.com)
  • Aminoglycoside (6′) acetyltransferase-Ie/aminoglycoside (2″) phosphotransferase-Ia [AAC(6′)-Ie/APH(2″)-Ia] is one of the most problematic aminoglycoside resistance factors in clinical pathogens, conferring resistance to almost every aminoglycoside antibiotic available to modern medicine. (asm.org)
  • Drew, "Frequency of UL97 phosphotransferase mutations related to ganciclovir resistance in clinical cytomegalovirus isolates," Journal of Infectious Diseases, vol. (thefreedictionary.com)
  • TRPT1, also known as tRNA 2"-phosphotransferase 1, catalyzes the last step of tRNA splicing, the transfer of the splice junction 2"-phosphate from ligated tRNA to NAD to produce ADP-ribose 1"-2" cyclic phosphate. (creativebiomart.net)
  • Metabolic labeling experiments in whole cells showed that NMDA receptor overactivation does not modify the activity of phosphocholine or phosphoethanolamine cytidylyltransferases but strongly inhibits choline-ethanolamine phosphotransferase activity. (jneurosci.org)
  • The serum lysosomal enzymes were strikingly elevated and GlcNAc-1-phosphotransferase activity in the patient's fibroblasts was 3% of normal. (unboundmedicine.com)
  • Strains of N.C.I.B. 8258 had no detectable activity, but its glucose-phosphoenolpyruvate phosphotransferase specific activity and that of the other strains were closely similar, and it is concluded that this phosphotransferase activity regulates the overall utilization of glucose, in which hexokinase plays no essential role. (biochemj.org)
  • 3, 4 The UDP -N- acetylglucosamine-1-phosphotransferase enzyme activity is defective in ML III 6 and three complementation groups (A, B, C) have been reported suggesting genetic heterogeneity. (bmj.com)
  • Beside its hydrolytic action, the low Mr PTPases demonstrate phosphotransferase activity [9-11]. (thefreedictionary.com)
  • 1. Extracts of several plant species contained nucleoside-AMP phosphotransferase activity. (portlandpress.com)
  • Evidence is presented that the total thymidine-AMP phosphotransferase activity of the leaves of Asplenium nidus (bird's-nest fern) and of Helianthus tuberosus (Jerusalem artichoke) increases during maturation. (portlandpress.com)
  • 2. Thymidine-AMP phosphotransferase was purified 22-fold from a very rich source of this activity, extracts of A. nidus. (portlandpress.com)
  • 5. Ca2+-activated ATP phosphohydrolase was separated from the phosphotransferase by differential complexing to Blue Dextran in the presence of urea, whereas an AMP phosphohydrolase activity was closely associated with thymidine-AMP phosphotransferase through all separation techniques used. (portlandpress.com)
  • It is suggested that this inhibitor would be of value in revealing the existence of thymidine kinase in plant extracts with high thymidine phosphotransferase activity. (portlandpress.com)
  • 6, 8 In 1996, Bao et al 9 showed that UDP -N- acetylglucosamine-1-phosphotransferase is a multimeric enzyme made up of three different subunits. (bmj.com)
  • 1 GlcNAc-1-phosphotransferase is a hexameric enzyme complex consisting of three different subunits: α 2 , β 2 , and γ 2 . (arvojournals.org)
  • Other names in common use include yeast 2'-phosphotransferase, Tpt1, Tpt1p, and 2'-phospho-tRNA:NAD+ phosphotransferase. (wikipedia.org)
  • Structural, biochemical, and geochemical considerations indicate that an acetate kinase may be the ancestral enzyme of the ASKHA (acetate and sugar kinases/Hsc70/actin) superfamily of phosphotransferases. (asm.org)
  • As a result of recent research efforts, an erythromycin ribosome methyltransferase, two aminoglycoside acetyltransferases, an aminoglycoside phosphotransferase, a rifamycin ADP-ribosyltransferase, a β-lactamase and a monooxygenase were identified to frame the complex and multifaceted intrinsic resistome of M. abscessus , which clearly contributes to complications in treatment of this highly resistant pathogen. (frontiersin.org)
  • The systematic name of this enzyme class is 3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase . (wikidoc.org)
  • Other names in common use include diphosphoglycerate-polyphosphate phosphotransferase , and 1,3-diphosphoglycerate-polyphosphate phosphotransferase . (wikidoc.org)
  • Bacterial PEP-dependent carbohydrate: phosphotransferase systems couple sensing and global control mechanisms. (semanticscholar.org)
  • A prerequisite for this method of drug design is a thorough knowledge of the catalytic mechanism of the enzyme, and as such I have characterized the regiospecificity and phosphoryl transfer mechanism of two aminoglycoside phosphotransferases: APH(3' )-IIIa and APH(9)-1a. (mcmaster.ca)