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PhosphatidylserinesAnnexin A5CDPdiacylglycerol-Serine O-PhosphatidyltransferaseApoptosisPhagocytosisPhospholipidsCell MembranePhosphatidylethanolaminesHydrocortisoneMembrane LipidsFatigue Syndrome, ChronicAppetiteSleepFatigueSkinParasympathetic Nervous SystemCircadian RhythmExerciseSalivaSleep, REMLongevityThiamin PyrophosphokinaseCaloric RestrictionLife ExpectancyHistamine ReleaseEthanolamineCompulsive BehaviorWeight LiftingEgg YolkSubarachnoid HemorrhageJumonji Domain-Containing Histone DemethylasesUmbilical VeinsReceptors, Cell SurfaceInfarction, Middle Cerebral ArteryBrain IschemiaNeurologyMemoryNeuropsychological TestsMemory DisordersCognition DisordersMemory, Short-TermAnnexin A2Annexin A1Annexin A6Annexin A4Fatty Acids, EssentialDocosahexaenoic AcidsFatty AcidsAscorbic Acid DeficiencyFatty Acids, UnsaturatedElectronic MailSpectrophotometry, InfraredSpectroscopy, Fourier Transform InfraredPeriodicals as TopicJournal Impact FactorPublishing
Phosphatidylserines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.Annexin A5: A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.CDPdiacylglycerol-Serine O-Phosphatidyltransferase: An enzyme that catalyzes the formation of phosphatidylserine and CMP from CDPdiglyceride plus serine. EC 2.7.8.8.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Phagocytosis: The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Phosphatidylethanolamines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids.Hydrocortisone: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.Membrane Lipids: Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.Fatigue Syndrome, Chronic: A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)Appetite: Natural recurring desire for food. Alterations may be induced by APPETITE DEPRESSANTS or APPETITE STIMULANTS.Sleep: A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Parasympathetic Nervous System: The craniosacral division of the autonomic nervous system. The cell bodies of the parasympathetic preganglionic fibers are in brain stem nuclei and in the sacral spinal cord. They synapse in cranial autonomic ganglia or in terminal ganglia near target organs. The parasympathetic nervous system generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system.Circadian Rhythm: The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.Exercise: Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.Saliva: The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.Sleep, REM: A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming.Longevity: The normal length of time of an organism's life.Thiamin Pyrophosphokinase: An enzyme that catalyzes the formation of thiamine pyrophosphate from ATP and thiamine. EC 2.7.6.2.Caloric Restriction: Reduction in caloric intake without reduction in adequate nutrition. In experimental animals, caloric restriction has been shown to extend lifespan and enhance other physiological variables.Life Expectancy: Based on known statistical data, the number of years which any person of a given age may reasonably expected to live.Histamine Release: The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects.Ethanolamine: A viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases.Compulsive Behavior: The behavior of performing an act persistently and repetitively without it leading to reward or pleasure. The act is usually a small, circumscribed behavior, almost ritualistic, yet not pathologically disturbing. Examples of compulsive behavior include twirling of hair, checking something constantly, not wanting pennies in change, straightening tilted pictures, etc.Weight Lifting: A sport in which weights are lifted competitively or as an exercise.Egg Yolk: Cytoplasm stored in an egg that contains nutritional reserves for the developing embryo. It is rich in polysaccharides, lipids, and proteins.Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.Jumonji Domain-Containing Histone Demethylases: A family of histone demethylases that share a conserved Jumonji C domain. The enzymes function via an iron-dependent dioxygenase mechanism that couples the conversion of 2-oxoglutarate to succinate to the hydroxylation of N-methyl groups.Umbilical Veins: Venous vessels in the umbilical cord. They carry oxygenated, nutrient-rich blood from the mother to the FETUS via the PLACENTA. In humans, there is normally one umbilical vein.Receptors, Cell Surface: Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.Neurology: A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.Memory: Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.Neuropsychological Tests: Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.Cognition Disorders: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.Memory, Short-Term: Remembrance of information for a few seconds to hours.Annexin A2: A member of the annexin family that is a substrate for a tyrosine kinase, ONCOGENE PROTEIN PP60(V-SRC). Annexin A2 occurs as a 36-KDa monomer and in a 90-KDa complex containing two subunits of annexin A2 and two subunits of S100 FAMILY PROTEIN P11. The monomeric form of annexin A2 was formerly referred to as calpactin I heavy chain.Annexin A1: Protein of the annexin family exhibiting lipid interaction and steroid-inducibility.Annexin A6: Protein of the annexin family with a probable role in exocytotic and endocytotic membrane events.Annexin A4: Protein of the annexin family originally isolated from the electric organ of the electric ray Torpedo marmorata. It has been found in a wide range of mammalian tissue where it is localized to the apical membrane of polarized EPITHELIAL CELLS.Fatty Acids, Essential: Long chain organic acid molecules that must be obtained from the diet. Examples are LINOLEIC ACIDS and LINOLENIC ACIDS.Docosahexaenoic Acids: C22-unsaturated fatty acids found predominantly in FISH OILS.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Ascorbic Acid Deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)Fatty Acids, Unsaturated: FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Spectrophotometry, Infrared: Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Spectroscopy, Fourier Transform Infrared: A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.

Role of class B scavenger receptor type I in phagocytosis of apoptotic rat spermatogenic cells by Sertoli cells. (1/2206)

Rat Sertoli cells phagocytose apoptotic spermatogenic cells, which consist mostly of spermatocytes, in primary culture by recognizing phosphatidylserine (PS) exposed on the surface of degenerating spermatogenic cells. We compared the mode of phagocytosis using spermatogenic cells at different stages of spermatogenesis. Spermatogenic cells were separated into several groups based on their ploidy, with purities of 60-90%. When the fractionated spermatogenic cell populations were subjected to a phagocytosis assay, cells with ploidies of 1n, 2n, and 4n were almost equally phagocytosed by Sertoli cells. All the cell populations exposed PS on the cell surface, and phagocytosis of all cell populations was similarly inhibited by the addition of PS-containing liposomes. Class B scavenger receptor type I (SR-BI), a candidate for the PS receptor, was detected in Sertoli cells. Overexpression of the rat SR-BI cDNA increased the PS-mediated phagocytic activity of Sertoli cell-derived cell lines. Moreover, phagocytosis of spermatogenic cells by Sertoli cells was inhibited in the presence of an anti-SR-BI antibody. Finally, the addition of high density lipoprotein, a ligand specific for SR-BI, decreased both phagocytosis of spermatogenic cells and incorporation of PS-containing liposomes by Sertoli cells. In conclusion, SR-BI functions at least partly as a PS receptor, enabling Sertoli cells to recognize and phagocytose apoptotic spermatogenic cells at all stages of differentiation.  (+info)

Kinetic and thermodynamic aspects of lipid translocation in biological membranes. (2/2206)

A theoretical analysis of the lipid translocation in cellular bilayer membranes is presented. We focus on an integrative model of active and passive transport processes determining the asymmetrical distribution of the major lipid components between the monolayers. The active translocation of the aminophospholipids phosphatidylserine and phosphatidylethanolamine is mathematically described by kinetic equations resulting from a realistic ATP-dependent transport mechanism. Concerning the passive transport of the aminophospholipids as well as of phosphatidylcholine, sphingomyelin, and cholesterol, two different approaches are used. The first treatment makes use of thermodynamic flux-force relationships. Relevant forces are transversal concentration differences of the lipids as well as differences in the mechanical states of the monolayers due to lateral compressions. Both forces, originating primarily from the operation of an aminophospholipid translocase, are expressed as functions of the lipid compositions of the two monolayers. In the case of mechanical forces, lipid-specific parameters such as different molecular surface areas and compression force constants are taken into account. Using invariance principles, it is shown how the phenomenological coefficients depend on the total lipid amounts. In a second approach, passive transport is analyzed in terms of kinetic mechanisms of carrier-mediated translocation, where mechanical effects are incorporated into the translocation rate constants. The thermodynamic as well as the kinetic approach are applied to simulate the time-dependent redistribution of the lipid components in human red blood cells. In the thermodynamic model the steady-state asymmetrical lipid distribution of erythrocyte membranes is simulated well under certain parameter restrictions: 1) the time scales of uncoupled passive transbilayer movement must be different among the lipid species; 2) positive cross-couplings of the passive lipid fluxes are needed, which, however, may be chosen lipid-unspecifically. A comparison of the thermodynamic and the kinetic approaches reveals that antiport mechanisms for passive lipid movements may be excluded. Simulations with kinetic symport mechanisms are in qualitative agreement with experimental data but show discrepancies in the asymmetrical distribution for sphingomyelin.  (+info)

Antibodies against phospholipids and oxidized LDL in alcoholic patients. (3/2206)

Antiphospholipid antibodies (APA) are a generic term describing antibodies that recognize various phospholipids. Hepatocyte damage is a cardinal event in the course of alcoholic liver injury and autoantibodies against phospholipids could play an important role in this process. APA in alcoholic patients seem to reflect membrane lesions, impairment of immunological reactivity, liver disease progression and they correlate significantly with disease severity. LDL oxidation is supposed to be one of the most important pathogenic mechanisms of atherosclerosis and antibodies against oxidized low-density lipoprotein (oxLDL) are some kind of an epiphenomenon of this process. The scope of our study was to determine some autoantibodies (IgG-oxLDL and antiphospholipid antibodies) and their possible changes in alcoholic patients. We studied IgG-oxLDL and four APA - anticardiolipin antibodies (ACA), antiphosphatidylserine antibodies (APSA) antiphosphatidylethanolamine antibodies (APE) and antiphosphatidylcholine antibodies (APCA) in 35 alcoholic patients with mildly affected liver function at the beginning of the abuse treatment. The control group consisted of 60 healthy blood donors. In the studied group, we obtained positive results concerning total ACA in 17.1 % of alcoholic patients (8.3 % in the control group), 11.4 % IgG-ACA (6.7 %), 8.6 % IgM-ACA (3.3 %), 14.3 % total APE (6.7 %), 14.3 % total APCA (8.3 %) and 20 % total APSA (8.3 % in the control group). The IgG-oxLDL (406.4+/-52.5 vs 499.9+/-52.5 mU/ml) was not affected in alcoholic patients. We conclude that the autoantibodies against oxLDL are present in sera of alcoholics and healthy blood donors. Based on our results which revealed a wide range of IgG-oxLDL titres in the healthy population, this parameter does not appear to be very promising for the evaluation of the risk of atherosclerosis. Alcoholics with only mild affection of liver functions did not exhibit a significantly higher prevalence of all studied antiphospholipid antibodies (ACA, APSA, APE, APCA) which could lead to membrane lesions in these patients.  (+info)

Plasmalogen status influences docosahexaenoic acid levels in a macrophage cell line. Insights using ether lipid-deficient variants. (4/2206)

Previously, this laboratory reported the isolation of variants, RAW. 12 and RAW.108, from the macrophage-like cell line RAW 264.7 that are defective in plasmalogen biosynthesis [Zoeller, R.A. et al. 1992. J. Biol. Chem. 267: 8299-8306]. Fatty acid analysis showed significant changes in the mutants in the ethanolamine phospholipids (PE), the only phospholipid class in which the plasmalogen species, plasmenylethanolamine, contributes significantly. Within the PE fraction, docosapentaenoic (DPA; 22:5n-3) and docosahexaenoic (DHA; 22:6n-3) acids were reduced by approximately 50% in the variants while the levels of arachidonic acid (AA; 20:4n-6) remained unaffected. The decrease in DHA was accompanied by a 50% decrease in labeling PE with [3H]DHA over a 90-min period. Restoration of plasmenylethanolamine by supplementing the growth medium with sn -1-hexadecylglycerol (HG) completely reversed these changes in RAW. 108. Pre-existing pools of plasmenylethanolamine were not required for restoration of normal [3H]DHA labeling; addition of HG only during the labeling period was sufficient. Due to the loss of Delta1'-desaturase in RAW.12, HG supplementation resulted in the accumulation of plasmenylethanolamine's immediate biosynthetic precursor, plasmanylethanolamine. Even though this latter phospholipid contained only the ether functionality (lacking the vinyl ether double bond) it was sufficient to restore wild type-like fatty acid composition and DHA labeling of the ethanolamine phospholipids, identifying the ether bond as a structural determinant for this specificity. In summary, we have used these mutants to establish that the plasmalogen status of a cell can influence the levels of certain polyunsaturated fatty acids. These results support the notion that certain polyunsaturated fatty acids, such as DHA, can be selectively targeted to plasmalogens and that this targeting occurs during de novo biosynthesis, or shortly thereafter, through modification of nascent plasmalogen pools.  (+info)

Binding of annexin V to plasma membranes of human spermatozoa: a rapid assay for detection of membrane changes after cryostorage. (5/2206)

When the cell membrane is disturbed, phospholipid phosphatidylserine (PS) is translocated from the inner to the outer leaflet of the plasma membrane. This is one of the earliest signs of apoptosis and can be monitored by the calcium-dependent binding of annexin V. Therefore, annexin V-binding, in conjunction with flow cytometry, was used to evaluate the integrity of the sperm plasma membrane after different cryostorage protocols: i.e. 10% (v/v) glycerol; sperm maintenance medium (MM); freezing medium TEST yolk buffer (TYB); or cryostorage without protection (cryoshock). Using a combination of two fluorescent dyes, annexin V and propidium iodide (PI), led to three groups of spermatozoa being identified: (i) viable spermatozoa (annexin V-negative and PI-negative); (ii) dead spermatozoa (annexin V-positive and PI-positive); and (iii) cells with impaired but integer plasma membrane (annexin V-positive and PI-negative). The percentage of vital annexin V-negative spermatozoa increased significantly (P < 0.05) from spermatozoa treated by cryoshock (15.0+/-1.2%) to spermatozoa cryopreserved by TYB (26.6+/-2.2%) via cryopreservation by 10% (v/v) glycerol (19.9+/-1.6%) and by MM (22.2 1.8%) and was associated with the percentage of motile spermatozoa (17.6+/-3.4% by glycerol; 19.6+/-3.7% by MM and 22.6+/-3.9% by TYB; P = 0.0001). Of the spermatozoa, 12-22% were annexin V-positive even though they did not bind to PI, indicating viability before as well as after cryostorage. The percentage of vital annexin V-positive spermatozoa was significantly correlated with different sperm motility parameters (velocity straight linear, r = 0.601, P = 0.018; percentage of linearly motile spermatozoa: r = 0.549, P = 0.034). We, therefore, concluded that annexin V-binding is more sensitive in detecting a deterioration of membrane functions than PI staining, and that a considerable percentage of spermatozoa might have dysfunctional plasma membranes besides dead or moribund cells. Of the cryopreservation protocols tested, TYB yielded the most viable spermatozoa. Therefore, we advocate the use of the annexin V-binding assay for the evaluation of the quality and integrity of spermatozoa.  (+info)

Enhancement of endocytosis due to aminophospholipid transport across the plasma membrane of living cells. (6/2206)

Formation of intracellular vesicles is initiated by membrane budding. Here we test the hypothesis that the plasma membrane surface area asymmetry could be a driving force for vesicle formation during endocytosis. The inner layer phospholipid number was therefore increased by adding exogenous aminophospholipids to living cells, which were then translocated from the outer to the inner layer of the membrane by the ubiquitous flippase. Addition of either phosphatidylserine or phosphatidylethanolamine led to an enhancement of endocytosis, showing that the observed acceleration does not depend on the lipid polar head group. Conversely, a closely related aminophospholipid that is not recognized by the flippase, lyso-alpha-phosphatidylserine, inhibited endocytosis, and similar results were obtained with a cholesterol derivative that also remains in the plasma membrane outer layer. Thus an increase of lipid concentration in the inner layer enhanced internalization, whereas an increase of the lipid concentration in the outer layer inhibited internalization. These experiments suggest that transient asymmetries in lipid concentration might contribute to the formation of endocytic vesicles.  (+info)

Synthesis and turnover of cerebrosides and phosphatidylserine of myelin and microsomal fractions of adult and developing rat brain. (7/2206)

The synthesis and turnover of cerebrosides and phospholipids was followed in microsomal and myelin fractions of developing and adult rat brains after an intracerebral injection of [U-14C]serine. The kinetics of incorporation of radioactivity into microsomal and myelin cerebrosides indicate the possibility of a precursor-product relationship between cerebrosides of these membranes. The specific radioactivity of myelin cerebrosides was corrected for the deposition of newly formed cerebrosides in myelin. Multiphasic curves were obtained for the decline in specific radioactivity of myelin and microsomal cerebrosides, suggesting different cerebroside pools in these membranes. The half-life of the fast turning-over pool of cerebrosides of myelin was 7 and 22 days for the developing and adult rat brain respectively. The half-life of the slowly turning-over pool of myelin cerebrosides was about 145 days for both groups of animals. The half-life of the rapidly turning-over microsomal cerebrosides was calculated to be 20 and 40 h for the developing and adult animals respectively. The half-life of the intermediate and slowly turning-over microsomal cerebrosides was 11 and 60 days respectively, for both groups of animals. The amount of incorporation of radioactivity into microsomal cerebrosides from L-serine was greatly decreased in the adult animals, and greater amounts of the precursor were directed towards the synthesis of phosphatidylserine. In the developing animals, considerable amounts of cerebrosides were synthesized from L-serine, besides phosphatidylserine. The time-course of incorporation indicated that a precursor-product relationship exists between microsomal and myelin phosphatidylserine. The half-life of microsomal phosphatidylserine was calculated to be about 8 h for the fast turning-over pool in both groups of animals.  (+info)

Interaction between terminal complement proteins C5b-7 and anionic phospholipids. (8/2206)

We have recently shown that C5b-6 binds to the erythrocyte membrane via an ionic interaction with sialic acid before the addition of C7 and subsequent membrane insertion. In this study we assessed the role of anionic lipids in the binding of the terminal complement proteins to the membrane and the efficiency of subsequent hemolysis. Human erythrocytes were modified by insertion of dipalmitoyl phosphatidylcholine (DPPC), dipalmitoyl phosphatidylserine (DPPS), dipalmitoyl phosphatidylethanolamine (DPPE), or dipalmitoyl phosphatidic acid (DPPA). Lipid incorporation and the hemolytic assays were done in the presence of 100 micromol/L sodium orthovanadate to prevent enzymatic redistribution of lipid. We found that the neutral lipids, DPPC and DPPE, did not affect C5b-7 uptake or hemolysis by C5b-9. In contrast, the two acidic phospholipids, DPPS and DPPA, caused a dose-dependent increase in both lysis and C5b-7 uptake. We conclude that the presence of anionic lipids on the exterior face of the membrane increases C5b-7 uptake and subsequent hemolysis. It is known that sickle cell erythrocytes have increased exposure of phosphatidylserine on their external face and are abnormally sensitive to lysis by C5b-9. The data presented here provide a plausible mechanism for this increased sensitivity.  (+info)

Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiprothrombin antibodies...Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiprothrombin antibodies...
TY - JOUR. T1 - Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiprothrombin antibodies. AU - Amengual, Olga. AU - Horita, Tetsuya. AU - Binder, Walter. AU - Norman, Gary L.. AU - Shums, Zakera. AU - Kato, Masaru. AU - Otomo, Kotaro. AU - Fujieda, Yuichiro. AU - Oku, Kenji. AU - Bohgaki, Toshiyuki. AU - Yasuda, Shinsuke. AU - Atsumi, Tatsuya. PY - 2014/9. Y1 - 2014/9. N2 - Phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) were strongly correlated with the presence of lupus anticoagulant showing a high specificity for the diagnosis of antiphospholipid syndrome. However, the main criticism for the clinical applicability of aPS/PT testing is the lack of reproducibility of the results among laboratories. In this study, we measured IgG and IgM aPS/PT using our original in-house enzyme-linked immunosorbent assays (ELISA) and commercial ELISA kits to assess the assay performance and to evaluate the accuracy of aPS/PT results. The ...
Inserm - Microbubble-Assisted Ultrasound-Induced Transient Phosphatidylserine TranslocationInserm - Microbubble-Assisted Ultrasound-Induced Transient Phosphatidylserine Translocation
Microbubble-assisted ultrasound (sonopermeabilization) results in reversible permeabilization of the plasma membrane of cells. This method is increasingly used in vivo because of its potential to deliver therapeutic molecules with limited cell damage. Nevertheless, the effects of sonopermeabilization on the plasma membrane remain not fully understood. We investigated the influence of sonopermeabilization on the transverse mobility of phospholipids, especially on phosphatidylserine (PS) externalization. We performed studies using optical imaging with Annexin V and FM1-43 probes to monitor PS externalization of rat glioma C6 cells. Sonopermeabilization induced transient membrane permeabilization, which is positively correlated with reversible PS externalization. This membrane disorganization was temporary and not associated with loss of cell viability. Sonopermeabilization did not induce PS externalization via activation of the scramblase. We hypothesize that acoustically induced membrane pores may
Phosphatidylserine and phospholipid scramblase in mast cell signaling | CU Digital RepositoryPhosphatidylserine and phospholipid scramblase in mast cell signaling | CU Digital Repository
6. CONCLUSIONS 1. We found that mast cell stimulation can induce PS externalization in the absence of secretory response. 2. We identified GPI-APs as molecules whose engagement can induce sustained and reversible non-apoptotic PS externalization. 3. GPI-AP-induced PS externalization was determined as non- apoptotic and distinct from the FceRl-induced PS externalization. 4. The effect of multiple triggering on PS externalization was additive and dependent on a tlpe of stimulus and cells engaged. 5. We identifred PLSCR1 as a molecule that becomes tyrosine phosphorylated in mast cells stimulated through GPI-APs. 6. We found that the PLSCR1 tyrosine phosphorylation is not associated with mast cell secretory response' and with GPI-AP- or FceRl-induced non-apoptotic PS externalization. 7. Using confocal microscopy and electron microscopy visualization of PLSCR1 in the course of mast cell activation we found that PLSCR1: (1) is not co-localized with extemalized PS, (2) is not co- localized with ...
Peregrine Pharmaceuticals Begins Dosing in Phase II Trial of Bavituximab - RedorbitPeregrine Pharmaceuticals Begins Dosing in Phase II Trial of Bavituximab - Redorbit
Peregrine Pharmaceuticals has announced that patient screening and dosing has begun in a Phase II trial designed to evaluate the safety and efficacy of bavituximab in combination with chemotherapy in patients with advanced breast cancer. The new trial is the second Phase II study evaluating bavituximab in advanced breast cancer patients, and Peregrine also is conducting a third Phase II combination therapy trial of bavituximab in non-small cell lung cancer patients. The primary objective of the new breast cancer study is to assess the overall tumor response rate to the combination of bavituximab with carboplatin and paclitaxel. Steven King, president and CEO of Peregrine, said: "The combination of bavituximab with the chemotherapy drugs carboplatin and paclitaxel performed well in an earlier Phase I study, and we look forward to learning more about bavituximabs potential in this larger breast cancer study. With three Phase II studies now underway, we look forward to significant clinical data ...
Now - Phosphatidyl Serine 100Mg 60 VcapsNow - Phosphatidyl Serine 100Mg 60 Vcaps
Phosphatidyl Serine 100mg with Choline & Inositol Phosphatidyl Serine is a phospholipid compound derived from soy lecithin and also a normal component of the brain. Phosphatidyl Serine powder is more stable, concentrated and cost effective compared to liquid softgel forms. Research has demonstrated that Phosphatidyl Serine may aid brain and nerve cell functions. This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Each Vegicap contains: Phosphatidyl Serine 100mg, Choline 100mg, Inositol 50mg Contains no yeast, wheat, corn, milk, sugar, salt, preservatives or color. Suggested Usage: As a dietary supplement, take 1 Vcap 1-3 times daily, preferably with meals.
Abstract 19922: Phosphatidylserine Receptor Upregulation in Stroke for Targeted Carrier Delivery | CirculationAbstract 19922: Phosphatidylserine Receptor Upregulation in Stroke for Targeted Carrier Delivery | Circulation
Introduction: The phosphatidylserine receptor (PSR) plays an important role in apoptosis and inflammation. Whether this receptor is expressed in damaged brain cells in the early stages of stroke is unknown.. Hypothesis: The purpose of this study was to determine if this receptor is expressed on ischemic neurovascular endothelial cells and if so, can it bind with PS-containing liposomes (PS-liposomes). The latter would allow for a neurovascular targeting strategy for therapeutic delivery to ischemic brain cells.. Methods: Sprague Dawley rats (n=22) were randomly divided into sham, cerebral ischemia, and subarachnoid hemorrhage (SAH) injury groups. Cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) for 2 hours using an intraluminal suture method. SAH was induced by an endovascular perforation method. Brain tissue was harvested for immunofluorescence staining at day 2 after surgery. Cultured human umbilical vein endothelial cells (HUVEC) were pre-treated with tumor necrosis ...
Positive Results In Bavituximab Combination Therapy Trial In Advanced Cancer Patients | EmaxHealthPositive Results In Bavituximab Combination Therapy Trial In Advanced Cancer Patients | EmaxHealth
We are encouraged to see objective responses in these patients with refractory advanced solid cancers after only a limited exposure to a regimen of bavituximab plus chemotherapy," said Joseph Shan, executive director of clinical and regulatory affairs at Peregrine. "We look forward to conducting the next set of clinical studies to further explore the potential of bavituximab as a novel cancer treatment.". The Phase Ib open label trial at clinical sites in India was designed to test the safety and tolerability of up to eight weekly doses of bavituximab given in combination with standard chemotherapy regimens including docetaxel, gemcitabine and carboplatin/paclitaxel. Study endpoints included safety, tolerability and pharmacokinetics. Although efficacy assessments were not formal endpoints of the study, patients were evaluated for tumor response according to Response Evaluation Criteria in Solid Tumors (RECIST) parameters, receiving CT or MRI scans prior to therapy and at the end of the ...
Data Presented at AACR Meeting Show Peregrines Bavituximab,Equivalent Can Generate Curative Immune Responses as Part of a...Data Presented at AACR Meeting Show Peregrine's Bavituximab,Equivalent Can Generate Curative Immune Responses as Part of a...
--Immunization with a Bavituximab Equivalent and Irradiated TumorCell...LOS ANGELES and TUSTIN Calif. April 18 2007/PRNewswire-FirstCall/ ...To confirm that the bavituximab equivalent 2aG4 acted byenhancing ant...Among the animals pre-treated with the 2aG4-treated irradiatedcells ...These data are particularly noteworthy because the glioma cellsused i...,Data,Presented,at,AACR,Meeting,Show,Peregrines,Bavituximab,Equivalent,Can,Generate,Curative,Immune,Responses,as,Part,of,a,Vaccine-Like,Regimen,in,Preclinical,Models,of,Aggressive,Brain,Cancer,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
665. WE-Heraeus-Seminar: Physical Approaches to Membrane Asymmetry665. WE-Heraeus-Seminar: Physical Approaches to Membrane Asymmetry
Scientific organizers: Prof. H. Heerklotz, U Freiburg • Dr. S. Fiedler, U Toronto/CAN Scope Cells and organelles establish different lipid compositions and properties in the outer and inner lipid leaflet. The complex and energy consuming machineries needed to regulate and maintain this state imply that membrane asymmetry is a key property for proper function of the membrane and, in turn, the survival of the cell. Until recently, this apparently crucial property could hardly be addressed in model membrane studies since asymmetric models were available only to a very limited extent. As a consequence, only rather few, pioneering studies have provided insight into the specific functions of membrane asymmetry. Presently, there is encouraging progress in developing easy-to-prepare, asymmetric membrane models in the form of liposomes, free standing bilayers, and solid supported membranes. It can be expected that such models will soon become the standard systems for biophysical membrane studies and
Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammationPhosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation
Ingestion of apoptotic cells in vitro by macrophages induces TGF-beta1 secretion, resulting in an anti-inflammatory effect and suppression of proinflammatory mediators. Here, we show in vivo that direct instillation of apoptotic cells enhanced the resolution of acute inflammation. This enhancement a …
Phosphatidylserine - Supplements - Nutrition ExpressPhosphatidylserine - Supplements - Nutrition Express
Low prices on Phosphatidylserine! Phosphatidylserine supports memory, focus and athletic performance*. Phosphatidylserine (PS) is a phospholipid (a fat containing phosphorus) found in every cell membrane in our bodies. It has many functions, but most important is its role in brain health. Clinical studies have shown PS to support brain glucose metabolism.
Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. -...Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. -...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Frontiers | Interleaflet Coupling, Pinning, and Leaflet Asymmetry-Major Players in Plasma Membrane Nanodomain Formation | Cell...Frontiers | Interleaflet Coupling, Pinning, and Leaflet Asymmetry-Major Players in Plasma Membrane Nanodomain Formation | Cell...
The plasma membrane has a highly asymmetric distribution of lipids and contains dynamic nanodomains many of which are liquid entities surrounded by a second, slightly different, liquid environment. Contributing to the dynamics is a continuous repartitioning of components between the two types of liquids and transient links between lipids and proteins, both to extracellular matrix and cytoplasmic components, that temporarily pin membrane constituents. This make plasma membrane nanodomains exceptionally challenging to study and much of what is known about membrane domains has been deduced from studies on model membranes at equilibrium. However, living cells are by definition not at equilibrium and lipids are distributed asymmetrically with inositol phospholipids, phosphatidylethanolamines and phosphatidylserines confined mostly to the inner leaflet and glyco- and sphingolipids to the outer leaflet. Moreover, each phospholipid group encompasses a wealth of species with different acyl chain combinations
Phosphatidyl Serine - Bodybuilding.comPhosphatidyl Serine - Bodybuilding.com
Phosphatidyl Serine (PS) is a phospholipid thats comprised of the amino acid L-serine and a lipid molecule. It is commonly extracted from cattle, egg yolks, or soybeans, and various plants.. It has been suggested that Phosphatidyl Serine may be important to healthy cell function in the body, primarily in the brain.*. Phosphatidyl Serine is thought to maintain nerve cell integrity, support neurotransmitter signal efficiency, maintain cognition, elevate mood, enhance memory, and encourage nutrient absorption in the brain. *. ...
Source Naturals Higher Mind w/ Phosphatidyl Serine - 90 Tablets Customer Reviews - eVitamins.comSource Naturals Higher Mind w/ Phosphatidyl Serine - 90 Tablets Customer Reviews - eVitamins.com
Read the latest Higher Mind w/ Phosphatidyl Serine by Source Naturals reviews and find the latest results, side effects and user experiences from eVitamins. Have you taken Higher Mind w/ Phosphatidyl Serine by Source Naturals? Submit your own Higher Mind w/ Phosphatidyl Serine review and let the world know what you think.
Source Naturals Higher Mind w Phosphatidyl Serine - 30 Tablets Customer Reviews - eVitamins.comSource Naturals Higher Mind w Phosphatidyl Serine - 30 Tablets Customer Reviews - eVitamins.com
Read the latest Higher Mind w Phosphatidyl Serine by Source Naturals reviews and find the latest results, side effects and user experiences from eVitamins. Have you taken Higher Mind w Phosphatidyl Serine by Source Naturals? Submit your own Higher Mind w Phosphatidyl Serine review and let the world know what you think.
De novo design of functional zwitterionic biomimetic material for immunomodulation | Science AdvancesDe novo design of functional zwitterionic biomimetic material for immunomodulation | Science Advances
During cell apoptosis, natural phosphatidylserines exposed on the outer membranes of apoptotic cells can prevent the occurrence of unexpected immune activation by directing antigen-presenting cells, such as macrophages and DCs that differentiate into the tolerogenic phenotype, and promoting the release of anti-inflammatory cytokines (28). To examine whether the PS-mimetic polymers can emulate the modulating effect of apoptotic cells and elicit anti-inflammatory responses in activated macrophages, we investigated the potential effect of ZPS, NZPS, and MPC on RAW 264.7 macrophages in the presence of lipopolysaccharide (LPS), an immunostimulatory molecule. For a fair comparison, ZPS, NZPS, and MPC were prepared into nanogels with uniform sizes (~40 nm) and surfaces (table S1). The zeta potential of anionic NZPS nanogel was negative (~−20 mv), while those of zwitterionic ZPS and MPC nanogels were close to neutral. RAW 264.7 macrophages (105 per well) were treated with nanogels composed of MPC, ...
Amphiphile-induced phosphatidylserine exposure in human erythrocytes - CONVERIS Research Information System - Converis 5 Åbo...Amphiphile-induced phosphatidylserine exposure in human erythrocytes - CONVERIS Research Information System - Converis 5 Åbo...
Nonionic and anionic water-soluble amphiphiles were shown to increase strongly the binding of fluorescein isothiocyanate-conjugated annexin V (FITC-annexin V) in human erythrocytes pretreated with the aminophospholipid translocase (APLT) inhibitor n-ethylmaleimide (NEM). At high sublytic amphiphile-concentrations the binding of FITC-annexin V, monitored in a flow cytometer, was time- and temperature-dependent and occurred heterogeneously in the cell population, with 43-81% of cells being stained above background following incubation for 60 minutes at 37 degrees C. The increased FITC-annexin V binding apparently indicates an increased flop rate of phosphatidylserine (PS) to the outer membrane leaflet. When the NEM-pretreatment was omitted, the FITC-annexin V binding was markedly, but not completely, reduced. In erythrocytes incubated with a zwitter-ionic amphiphile, a small increase in FITC-annexin V binding was detected, while cationic amphiphiles did not induce an increased FITC-annexin V ...
Peregrine Doses First Patient In Clinical Trial Of Bavituximab | EmaxHealthPeregrine Doses First Patient In Clinical Trial Of Bavituximab | EmaxHealth
This open-label, dose escalation study will be conducted in approximately 24 patients chronically infected with HCV and HIV. Patient cohorts will receive ascending dose levels of bavituximab weekly for up to eight weeks. HCV and HIV viral titers and other biomarkers will be evaluated, although they are not formal study endpoints.. In the United States alone, an estimated 300,000 individuals are co-infected with HCV and HIV, representing up to 30% of all HIV-infected patients. Co-infected patients have been shown to have a lower response to current HCV treatment regimens and the adverse effects of these regimens can be especially problematic for some HIV patients.. Bavituximab is a monoclonal antibody in a new class of anti-phosphotidylserine (PS) immunotherapeutics that targets and binds to cellular components that are normally not present on the outside of cells, but which become exposed on certain virally infected cells and on the surface of enveloped viruses, including both HCV and HIV. ...
Complete Inhibition of Viral Replication in H5N1 In Vivo Model by BavituximabComplete Inhibition of Viral Replication in H5N1 In Vivo Model by Bavituximab
Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM), a biopharmaceutical company with a portfolio of innovative, clinical stage product candidates for the treatment of hepatitis C virus (HCV) infection and cancer, today announced that its lead anti-viral compound bavituximab (formerly Tarvacin) completely inhibited replication of a laboratory strain of the H5N1 virus, commonly known as avian flu, in fertilized chicken eggs, an in vivo model for influenza anti- viral activity. These preliminary findings will be reported today at the 106th general meeting of The American Society for Microbiology (ASM) in Orlando, Florida by Dr. Philip Thorpe, a member of the Peregrine Scientific Resource Board and professor of pharmacology at the University of Texas Southwestern Medical Center at Dallas. Bavituximab, a monoclonal antibody with unique anti-viral and anti-cancer properties, has already demonstrated good tolerability in a Phase l trial in patients with HCV infection ...
Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytesMechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes
The appearance of phosphatidylserine (PS) on the cell surface during apoptosis in thymocytes and cytotoxic T lymphocyte cell lines provokes PS-dependent recognition by activated macrophages. Flow cytometric analysis of transbilayer lipid movements in T lymphocytes undergoing apoptosis reveals that d …
P2X7 receptor activation causes phosphatidylserine exposure in human erythrocytesP2X7 receptor activation causes phosphatidylserine exposure in human erythrocytes
Sluyter, R., Shemon, A. & Wiley, J. S. (2007). P2X7 receptor activation causes phosphatidylserine exposure in human erythrocytes. Biochemical and Biophysical Research Communications, 355 169-173 ...
Sequential shrinkage and swelling underlie P2X(7)-stimulated lymphocyte phosphatidylserine exposure and death - Surrey...Sequential shrinkage and swelling underlie P2X(7)-stimulated lymphocyte phosphatidylserine exposure and death - Surrey...
Taylor, SRJ, Gonzalez-Begne, M, Dewhurst, S, Chimini, G, Higgins, CF, Melvin, JE and Elliott, JI (2008) Sequential shrinkage and swelling underlie P2X(7)-stimulated lymphocyte phosphatidylserine exposure and death ...
Phosphatidyl Serine 100 mg 30 gels by Carlson Labs - Premier FormulasPhosphatidyl Serine 100 mg 30 gels by Carlson Labs - Premier Formulas
Carlson Labs - Phosphatidyl-Serine - Phosphatidyl Serine 100 mg 30 gels: $ 19.9 - Physician Formulated, Prescription-Grade Supplements - FREE Shipping
Phosphatidyl Serine (Extra Strength) 300 mg - Protocol for Life BalancePhosphatidyl Serine (Extra Strength) 300 mg - Protocol for Life Balance
Phosphatidyl Serine (PS) is a naturally occurring phospholipid that is found in especially high concentrations in the cellular membranes of brain and nerve tissues.* PS supports neuronal membrane fluidity and facilitates intercellular communication for healthy neurocognitive function.* PS thus supports the normal utilization of neurotransmitters in the brain.* Research shows that PS supplementation can promote cognitive function and mental acuity.* This extra strength product has three times the Phosphatidyl Serine (300 mg per softgel) than our regular strength product (100 mg per softgel ...
British Library EThOS: Mechanisms of red cell turnover (eryptosis)British Library EThOS: Mechanisms of red cell turnover (eryptosis)
When CD47 is ligated with a specific ligand, phosphatidylserine exposure is observed on the surface of the erythrocyte in a process known as eryptosis, which is similar to apoptosis. The aim of this study was to identify new proteins within the CD47 receptor mediated phosphatidylserine pathway and to elucidate the functions of any newly identified proteins. Previous research had suggested a link between protein 4.1R and CD47. Therefore, diseased protein 4.1R deficient erythrocytes were used as a molecular tool to help explore the role of protein 4.1R in the CD47 pathway. To achieve this aim, flow cytometry to measure phosphatidylserine exposure, 1D and 2D protein immunoblotting, 1D and 2D electrophoresis, RS100 ProteinChips coupled to SELDI-TOF, Q-TOF and MALDI-TOF, calcium influx, 2D serine/threonine phosphoblots and protein kinase A and protein kinase C inhibition were employed. Results showed increased phosphatidylserine exposure in 4.1R deficient erythrocytes and protein immunoblots ...
Preventing Airway Hypercontractility | Science SignalingPreventing Airway Hypercontractility | Science Signaling
Asthma is associated with airway obstruction, airway inflammation, and bronchoconstriction. Immune cell infiltration and their production of inflammatory cytokines, such as interleukin (IL)-13, IL-17A, and tumor necrosis factor-α (TNF-α), increase airway smooth muscle contractility by increasing the calcium sensitivity of a pathway involving the guanosine triphosphatase RhoA, the kinase ROCK2, myosin light chain phosphatase, and myosin light chain. Mfge8 is an integrin-binding and phosphatidylserine-binding protein that functions in the clearance of apoptotic cells. Comparison of wild-type and mfge8-deficient mice in a mouse model of asthma (induced by ovalbumin) revealed that the mfge8-deficient mice had increased pulmonary resistance, a measure of airway hyperresponsiveness, but the abundance of infiltrated immune cells, the types of cells present, and the abundance of the inflammatory cytokines were the same between the two genotypes of mice. Isolated tracheal rings from the ...
Product information, instructions, health benefits, and usage for Phosphatidyl SerineProduct information, instructions, health benefits, and usage for Phosphatidyl Serine
Phosphatidyl Serine list and information including what is Phosphatidyl Serine, health benefits and usage indications. Find articles and product list for other top low-carb products, fat-burners, nutrition bars and shakes.
Phosphatidyl Serine - Cape Fear Naturals - $20.95 - Cape Fear Naturals, LLCPhosphatidyl Serine - Cape Fear Naturals - $20.95 - Cape Fear Naturals, LLC
Phosphatidyl Serine supplements can help replenish phosphatidyl serine levels***, supports normal brain function***, clear thinking*** & a healthy mind***.
Pure Encapsulations - PS 100 (phosphatidylserine) - 120Pure Encapsulations - PS 100 (phosphatidylserine) - 120
PS 100 (standardized phosphatidylserine) Supports mental function Phosphatidylserine is a phospholipid found in all cells, but is most concentrated in brain cells. This familiarly-called brain nutrient supports cognitive function, emotional well-being and behavioral performance by restoring cell membrane composition. It has also been shown to support memory. In a double blind placebo controlled multicenter study of 425 individuals, daily supplementation of phosphatidylserine over six months resulted in statistically significant support of behavioral and cognitive parameters. In another six-month study of 40 individuals, phosphatidylserine supplementation enhanced cerebral metabolism and outcomes of cognitive training. These findings are consistent with earlier studies. In a placebo- controlled investigation of 149 subjects, the group receiving phosphatidylserine scored higher than placebo in performance tests related to memory tasks of daily life. In a trial of 35 subjects, those receiving
DSpace ISS: Expression of phosphatidylserine receptor and down-regulation of pro-inflammatory molecule production by its...DSpace ISS: Expression of phosphatidylserine receptor and down-regulation of pro-inflammatory molecule production by its...
De Simone R, Ajmone-Cat MA, Nicolini A, Minghetti L. Expression of phosphatidylserine receptor and down-regulation of pro-inflammatory molecule production by its natural ligand in rat microglial cultures. Journal of neuropathology and experimental neurology 2002;61(3):237-244 ...
Peregrine Pharmaceuticals Announces Five Abstracts Accepted for Presentation at AACR 2017 Annual Meeting (NASDAQ:PPHM)Peregrine Pharmaceuticals Announces Five Abstracts Accepted for Presentation at AACR 2017 Annual Meeting (NASDAQ:PPHM)
Bavituximab is an investigational monoclonal antibody that targets PS. Signals from PS inhibit the ability of immune cells to recognize and fight tumors. Bavituximab is believed to override PS mediated immunosuppressive signaling by blocking the engagement of PS with its receptors as well as by sending an alternate immune activating signal. Previous studies demonstrated PS-targeting antibodies shift the functions of immune cells in tumors, resulting in multiple signs of immune activation and anti-tumor responses. Peregrines clinical development strategy for bavituximab currently focuses on small, early-stage, proof-of-concept trials evaluating the drug in combination with other cancer treatments. As part of this approach the National Comprehensive Cancer Network (NCCN) has awarded grants to support three different clinical trials of bavituximab treatment combinations. These trials will evaluate novel bavituximab combinations in glioblastoma, head and neck cancer, and hepatocellular carcinoma ...
PHOSPHATIDYL SERINEPHOSPHATIDYL SERINE
Buy PHOSPHATIDYL SERINE Online.Phosphatidylserine consists of phosphatidylserine which is a phospholipid of vital importance for the good working order of the brain. On the other hand, Phosphatidylserine increa
Infrared spectra of brain phosphatidylserine | Biochemical JournalInfrared spectra of brain phosphatidylserine | Biochemical Journal
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Externalization of phosphatidylserine may not be an early signal of apoptosis in neuronal cells, but only the...Externalization of phosphatidylserine may not be an early signal of apoptosis in neuronal cells, but only the...
TY - JOUR. T1 - Externalization of phosphatidylserine may not be an early signal of apoptosis in neuronal cells, but only the phosphatidylserine-displaying apoptotic cells are phagocytosed by microglia. AU - Adayev, Tatyana. AU - Estephan, Rima. AU - Meserole, Susan. AU - Mazza, Bethanne. AU - Yurkow, Edward J.. AU - Banerjee, Probal. PY - 1998/11/1. Y1 - 1998/11/1. N2 - Earlier reports on nonneural cells have shown that the normally inner plasma membrane lipid, phosphatidylserine (PS), flip-flops out during the early stages of apoptosis, whereas DNA laddering and plasma membrane permeabilization occur during the late stages. In this study, the applicability of these parameters to CNS-derived neuronal cells was tested using hippocampal HN2-5, cells that undergo apoptosis under anoxia. Because such insults on unsynchronized cells, e.g., undifferentiated HN2-5 cells, result in both early and late apoptotic cells, we mechanically separated these cells into three fractions containing (a) cells that ...
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Metastases are a major cause of cancer mortality. AXL, a receptor tyrosine kinase aberrantly expressed in many tumors, is a potent oncogenic driver of metastatic cell motility and has been identified as broadly relevant in cancer drug resistance. Despite its frequent association with changes in cancer phenotypes, the precise mechanism leading to AXL activation is incompletely understood. In addition to its ligand growth arrest specific-6 (Gas6), activation of AXL requires the lipid moiety phosphatidylserine (PS). Phosphatidylserine is only available to mediate AXL activation when it is externalized on cell membranes, an event that occurs during certain physiologic processes such as apoptosis. Here, it is reported that exposure of cancer cells to phosphatidylserine-containing vesicles, including synthetic liposomes and apoptotic bodies, contributes to enhanced migration of tumor cells via a PS-Gas6-AXL signaling axis. These findings suggest that anticancer treatments that induce fractional cell ...
Sub-domain structure of lipid-bound annexin-V resolved by electron image analysis. - Semantic ScholarSub-domain structure of lipid-bound annexin-V resolved by electron image analysis. - Semantic Scholar
Two-dimensional crystals of annexin-V bound to lipid layers containing dioleoylphosphatidylserine have been obtained in the presence of Ca2+. The crystals diffract to 20 A resolution and have the symmetry of the plane group p3 (unit cell dimensions: a = b = 94 A, gamma = 120 degrees). Electron image analysis revealed that the crystals are composed of trimers of annexin-V forming triskelion-like motifs. Each annexin-V molecule has a characteristic elongated shape, about 65 A by 20 A, when observed perpendicularly to the crystal plane. It is composed of two staggered domains of similar size, about 40 A by 20 A. Both domains are made of two sub-domains. The present data suggest that the four resolved sub-domains represent the folding units corresponding to the four 70 amino acid repeating segments characteristic of all annexins.
Phosphatidyl Serine - 60 Capsules - - Seeking HealthPhosphatidyl Serine - 60 Capsules - - Seeking Health
Phosphatidyl Serine by Seeking Health provides 100 mg of phosphatidylserine (PS) from non-GMO sunflower lecithin. This natural phospholipid may help support ...
Phosphatidylserine - Golden Horizon BiologicsPhosphatidylserine - Golden Horizon Biologics
Golden Horizon Biologics is phosphatidylserine manufacture. This page describes the introduction of phosphatidylserine, phosphatidylserine benefits and phosphatidylserine use
PHOSPHATIDYLSERINE: Uses, Side Effects, Interactions and Warnings - WebMDPHOSPHATIDYLSERINE: Uses, Side Effects, Interactions and Warnings - WebMD
Find patient medical information for PHOSPHATIDYLSERINE on WebMD including its uses, effectiveness, side effects and safety, interactions, user ratings and products that have it.
Peregrine Announces Positive Top-Line Data From Randomized, Double-Blind Bavituximab Phase II Trial in Second-Line Non-Small...Peregrine Announces Positive Top-Line Data From Randomized, Double-Blind Bavituximab Phase II Trial in Second-Line Non-Small...
TUSTIN, CA -- (Marketwire) -- 05/21/12 -- Peregrine Pharmaceuticals, Inc. (NASDAQ: PPHM) today announced positive top-line results from its randomized, double-blind, placebo-controlled Phase IIb trial evaluating two dose levels of bavituximab plus docetaxel versus docetaxel plus placebo (control arm) in patients with second-line non-small ...
Peregrine Announces Positive Top-Line Data From Randomized, Double-Blind Bavituximab Phase II Trial in Second-Line Non-Small...Peregrine Announces Positive Top-Line Data From Randomized, Double-Blind Bavituximab Phase II Trial in Second-Line Non-Small...
Bavituximab Plus Chemotherapy Demonstrates Doubling of Overall Response Rates Versus Chemotherapy Alone 50 Improvement in Progression-Free Survival and Overall
Progressive Laboratories Phosphatidyl Serine - 60 capsules | AccutritionProgressive Laboratories Phosphatidyl Serine - 60 capsules | Accutrition
Progressive Laboratories Phosphatidyl Serine contains phospholipids, particularly phosphatidylserine, which support cognitive functions such as memory and learning, cell membrane flexibility and normal cortisol levels.
Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase | The EMBO JournalTransport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase | The EMBO Journal
In the present study, we showed in mammalian cells that a P4‐ATPase ATP8A1 translocates PS from the luminal leaflet to the cytosolic leaflet in the RE membranes. We also found that a membrane fission protein EHD1, which binds PS in vitro, is dispersed from REs to the cytoplasm by ATP8A1 depletion. Cells depleted of ATP8A1 generate extensively tubulated membranes from REs, which appear resistant to fission. Cells depleted of EHD1 also generate tubular membranes from REs. From these results, we propose that the flipping of PS to the cytosolic leaflet by a P4‐ATPase is critical for recruiting a membrane fission protein to the RE membranes and generating transport vesicles from REs. Studies in Saccharomyces cerevisiae have shown that a P4‐ATPase Drs2, which flips PS and to a lesser extent PE, is essential for membrane traffic between the late Golgi compartment and endosomes (Sebastian et al, 2012) and that other P4‐ATPases Dnf1 and Dnf2, which flip phospholipids such as PC and PE, ...
Phosphatidyl-Serine 100 mg Soy FreePhosphatidyl-Serine 100 mg Soy Free
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Regeneration of the nervous system. Nutritional and dietary supplements Muscle-Zone.pl. A wide selection of Phosphatidylserine at affordable prices. The best supplements available on the market. CHECK HERE!
Phosphatidyl SerinePhosphatidyl Serine
Progressive Laboratories Phosphatidyl Serine supports cognitive functions such as memory and learning, cell membrane flexibility and normal cortisol levels.
Phosphatidyl Serine SoftgelsPhosphatidyl Serine Softgels
Phosphatidyl Serine (PS) is a naturally occurring nutrient and is an essential component of human cells. Large amounts of PS are found in the brain ...
METHOD FOR PRODUCING LIPOSOME AND METHOD FOR DISSOLVING CHOLESTEROL - Patent applicationMETHOD FOR PRODUCING LIPOSOME AND METHOD FOR DISSOLVING CHOLESTEROL - Patent application
0028] In the method for producing liposomes according to the present invention, one or more lipids such as soybean lecithin, hydrogenated soybean lecithin, egg yolk lecithin, phosphatidylcholines, phosphatidylserines phosphatidylethanolamines, phosphatidyl inositols, sphingomyelins, phosphatidic acids, long-chain alkyl phosphates, gangliosides, glycolipids, phosphatidyl glycerols, and sterols, can be used. Phosphatidylcholines can be exemplified by dimyristoylphosphatidylcholine, dipalmitoylphosphatidylcholine, distearoylphosphatidylcholine, etc. Phosphatidylserines can be exemplified by dipalmitoyl phosphatidylserine, dipalmitoyl phosphatidylserine (sodium salt), phosphatidylserine (sodium salt) derived from bovine brain, etc. Phosphatidylethanolamines can be exemplified by dimyristoylphosphatidylethanolamine, dipalmitoylphosphatidylethanolamine, distearoylphosphatidylethanolamine, etc. Phosphatidyl inositols can be exemplified by phosphatidylinositol (sodium salt) derived from wheat, etc. ...
Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated...Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated...
The effect of glucosylceramide (GlcCer) on activated protein C (APC)-phospholipid interactions was examined using fluorescence resonance energy transfer. Human APC, labeled with either fluorescein (Fl-APC) or dansyl (DEGR-APC) donor, bound to phosphatidylcholine/phosphatidylserine (PC/PS, 9:1 w/w) vesicles containing octadecylrhodamine (OR) acceptor with a K(d) (app) = 16 micro g/ml, whereas Fl-APC (or DEGR-APC) bound to PC/PS/GlcCer(OR) (8:1:1) vesicles with a K(d) (app) = 3 micro g/ml. This 5-fold increase in apparent affinity was not species-specific since bovine DEGR-APC also showed a similar GlcCer-dependent enhancement of binding of APC to PC/PS vesicles. From the efficiency of fluorescence resonance energy transfer, distances of closest approach of approximately 63 and approximately 64 A were estimated between the dansyl on DEGR-APC and rhodamine in PC/PS/GlcCer(OR) and PC/PS(OR), respectively, assuming kappa(2) = 2/3. DEGR-APC bound to short chain C8-GlcCer with an apparent K(d) of 460 ...
4-Hydroxy-2-Nonenal Enhances Tissue Factor Activity in Human Monocytic Cells via p38 Mitogen-Activated Protein Kinase...4-Hydroxy-2-Nonenal Enhances Tissue Factor Activity in Human Monocytic Cells via p38 Mitogen-Activated Protein Kinase...
Approach and Results-TF activity and antigen levels on intact cells were measured using factor Xa generation and TF monoclonal antibody binding assays, respectively. Exposure of phosphatidylserine on the cell surface was analyzed using thrombin generation assay or by binding of a fluorescent dye-conjugated annexin V. 2′,7′-dichlorodihydrofluorescein diacetate was used to detect the generation of reactive oxygen species. Our data showed that HNE increased the procoagulant activity of unperturbed THP-1 cells that express traces of TF antigen, but had no effect on unperturbed endothelial cells that express no measurable TF antigen. HNE increased TF procoagulant activity but not TF antigen of both activated monocytic and endothelial cells. HNE treatment generated reactive oxygen species, activated p38 mitogen-activated protein kinase, and increased the exposure of phosphatidylserine at the outer leaflet in THP-1 cells. Treatment of THP-1 cells with an antioxidant, N-acetyl cysteine, suppressed ...
Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis | Journal of NeuroscienceEvidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis | Journal of Neuroscience
The present findings demonstrate that the lipid peroxidation product HNE can induce apoptosis in PC12 cells and primary rat hippocampal neurons and suggest that HNE is a mediator of oxidative stress-induced apoptosis. HNE induced loss of plasma membrane phosphatidylserine asymmetry (detected by annexin-V binding) and nuclear condensation and DNA fragmentation in PC12 cells and hippocampal neurons. HNE-induced cell death was prevented by cycloheximide, actinomycin-D, and aurintricarboxylic acid, consistent with a role for macromolecular synthesis and endonuclease activity in the cell death process. Although we recently reported that low concentrations of cycloheximide that do not cause sustained blockade of protein synthesis can protect neurons against excitotoxic and oxidative insults by a mechanism that apparently involves stimulation of antioxidant pathways (Furukawa et al., 1997), the concentration of cycloheximide used in the present study (10 μm) causes an essentially complete and ...
Myelin alters the inflammatory phenotype of macrophages by activating PPARs | Acta Neuropathologica Communications | Full TextMyelin alters the inflammatory phenotype of macrophages by activating PPARs | Acta Neuropathologica Communications | Full Text
Foamy macrophages, containing myelin degradation products, are abundantly found in active multiple sclerosis (MS) lesions. Recent studies have described an altered phenotype of macrophages after myelin internalization. However, mechanisms by which myelin affects the phenotype of macrophages and how this phenotype influences lesion progression remain unclear. We demonstrate that myelin as well as phosphatidylserine (PS), a phospholipid found in myelin, reduce nitric oxide production by macrophages through activation of peroxisome proliferator-activated receptor β/δ (PPARβ/δ). Furthermore, uptake of PS by macrophages, after intravenous injection of PS-containing liposomes (PSLs), suppresses the production of inflammatory mediators and ameliorates experimental autoimmune encephalomyelitis (EAE), an animal model of MS. The protective effect of PSLs in EAE animals is associated with a reduced immune cell infiltration into the central nervous system and decreased splenic cognate antigen specific
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Suicidal erythrocyte death, eryptosis, as a novel mechanism in heart failure-associated anaemia | Biomedical Data JournalSuicidal erythrocyte death, eryptosis, as a novel mechanism in heart failure-associated anaemia | Biomedical Data Journal
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MACS/FertilitypediaMACS/Fertilitypedia
MACS technique eliminates apoptotic sperms and may be indicated prior to ICSI, in order to guarantee that the injected spermatozoa are not damaged at a molecular level. Alternatively it could be combined with PICSI.. The externalization of the phospholipid phosphatidylserine (PS) to the sperm plasma membrane is a characteristic feature of the apoptotic phenomenon that occurs early during the process of sperm cell death. This basic knowledge has prompted investigators to develop a magnetic-based selection system for sperm cells that can separate early apoptotic from non-apoptotic germ cells (MACS).. Human sperm quality is defined by the classical parameters, concentration, motility and morphology, according to standard WHO diagnostic semen analysis. Nevertheless, hidden anomalies affecting spermatozoa membranes and causing apoptosis are present. Such features are not routinely detected in ejaculated spermatozoa but they have been proven to have a negative impact on ART outcome. Indeed, successful ...
Annexin V-Biotin Apoptosis Detection Kit | GeneTexAnnexin V-Biotin Apoptosis Detection Kit | GeneTex
The Annexin V-Biotin Apoptosis Detection Kit is based on the observation that soon after initiating apoptosis, most cell types translocate the membrane phospholipid phosphatidylserine (PS) from the inner face of the plasma membrane to the cell surface. Once on the cell surface, PS can easily bind to Biotin-conjugated Annexin V, a protein that has a strong natural affinity for PS. Annexin V-Biotin can be detected in conjunction with conventional dye-staining using any streptavidine- or avidin-dye reagents, such as (strept)avidine-fluorescein, -peroxidase, -alkaline phosphatase (AP), and -β-gal, etc. |p>‧ Detection method- Flow cytometry (Ex = 488 nm; Em = 530 nm) using and fluorescence microscopy |br>‧ Sample type- Living cells (suspension and adherant)|br>‧ Species reactivity- Mammalian |br>‧ Applications- Detect early/middle stages of apoptosis; differentiate apoptosis from necrosis.|p>|b>Features and Benefits|/b>|br>‧ Simple one step staining procedure in 30 minutes|br>‧ Fast and
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Phosphatidylserine for cognition and cortisol management - XbodyConceptsPhosphatidylserine for cognition and cortisol management - XbodyConcepts
Studies suggest phosphatidylserine has an effect on neurotransmitters that may play a role in cognitive functions. It has been shown that treatment with phosphatidylserine enhances cholinergic neurotransmission [2,3] and even increases the turnover of dopamine and norepinephrine in the brain [4].. In 1986 Delwaide et al. [5] reported that patients suffering from senile dementia improved their cognitive disorder with oral phosphatidylserine supplementation (derived from bovine brain cortex). Bovine brain cortex derived phosphatidylserine has also been shown to shift EEG power more towards the normal level in patients with mild primary degenerative dementia [6]; improved behavioral and cognitive parameters were also observed [7] as well as improved learning and memory in aged rodents [8,10].. However, because of concerns about mad cow disease (bovine spongiform encephalopathy [BSE]) [9], commercially available products are now made from cabbage or soy. Although the fatty acid composition of ...
Publications | african drylands institute for sustainabilityPublications | african drylands institute for sustainability
The (Na+ +K+)-activated, Mg2+-dependent ATPase from rabbit kidney outer medulla was prepared in a partially inactivated, soluble form depleted of endogenous phospholipids, using deoxycholate. This preparation was reactivated 10 to 50-fold by sonicated liposomes of phosphatidylserine, but not by non-sonicated phosphatidylserine liposomes or sonicated phosphatidylcholine liposomes. The reconstituted enzyme resembled native membrane preparations of (Na+ +K+)-ATPase in its pH optimum being around 7.0, showing optimal activity at Mg2+:ATP mol ratios of approximately 1 and a Km value for ATP of 0.4 mM. Arrhenius plots of this reactivated activity at a constant pH of 7.0 and an Mg2+: ATP mol ratio of 1:1 showed a discontinuity (sharp change of slope) at 17 degrees C, with activation energy (Ea) values of 13-15 kcal/mol above this temperature and 30-35 kcal below it. A further discontinuity was also found at 8.0 degrees C and the Ea below this was very high (greater than 100 kcal/mol). Increased Mg2+ ...
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Plus itPlus it
The present study provides evidence that the tirucallic acid isomer αATA(8,24) is more potent than tirucallic acid derivatives investigated so far with respect to induction of apoptotic cell death in prostate cancer cells in vitro and in vivo. Furthermore, the differential selectivity of the tirucallic acid derivatives in destroying cancer cells without overt cytotoxicity to normal cells encouraged us to analyze the mechanisms of their toxicity.. Cell death occurs mostly dichotomously as either apoptosis or necrosis. Apoptosis is an active, programmed process of autonomous cellular dismantling that does not elicit inflammation known to be produced by necrosis (Fink and Cookson, 2005). Therefore, drugs leading to apoptotic cell death are of great interest in biomedical and pharmaceutical research. On the basis of several markers of apoptosis, such as loss of membrane phospholipid asymmetry resulting in phosphatidylserine externalization, caspase-3 activation, and the late-occurring DNA ...
Download Autoantibodies and Autoimmunity: Molecular Mechanisms in by Kenneth Michael Pollard PDF - MK Plast Book ArchiveDownload Autoantibodies and Autoimmunity: Molecular Mechanisms in by Kenneth Michael Pollard PDF - MK Plast Book Archive
Kono. 2002. A genetic analysis of lupus. Allergy 57 Suppl 72:67-74. Croker, B. , G. Gilkeson, and L. Morel. 2003. Genetic interactions between susceptibility loci reveal epistatic pathogenic networks in murine lupus. Genes Immun 4:575-585. , X. H. Tian, B. P. Croker, and E. K. Wakeland. 1999. Epistatic modifiers of autoimmunity in a murine model of lupus nephritis. Immunity 11:131-139. , J. Kappler, and B. L. Kotzin. 2001. Autoimmune disease: why and where it occurs. Nat Med 7:899-905. Rubin, R. 2002. Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest 109:41-50. , B. Krammer, and G. Schwamberger. 1999. Cutting edge: differential effect of apoptotic versus necrotic tumor cells on macrophage antitumor activities. J Immunol 163:1730-1732. Pollard, K. , D. L. Pearson, M. Bluthner, and E. M. Tan. 2000. Proteolytic cleavage of a self-antigen following xenobiotic-induced cell death produces a fragment with novel ...
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PKC is a major intracellular receptor for the mouse skin tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). PKC represents a large family of phosphatidylserine-dependent serine/threonine kinases. Protein kinase Cε (PKCε) is a member of the novel PKC sub-family. PKCε is a transforming oncogene and a predictive biomarker of various human cancers, including prostate cancer (PCa). We have shown that PKCε expression level correlates with human PCa aggressiveness. PKCε overexpression is sufficient to transform androgen-dependent LNCaP cells into an androgen-independent variant, which rapidly initiates growth in vivo in both intact and castrated male nude mice. PKCε silencing using specific siRNA in DU145 cells inhibits Stat3-regulated gene expression (COX-2) and cell invasion. Also, PKCε deletion (even one allele) in TRAMP mice prevents development of PCa. Taken together, the evidence indicates an association of PKCε to PCa development and aggressiveness. Thus, PKCε may be a potential ...
KIM-1 Signalling In Ischemic AKI and Phagocytosis by Ola Z. Ismail"KIM-1 Signalling In Ischemic AKI and Phagocytosis" by Ola Z. Ismail
Acute kidney injury (AKI) is defined by the rapid loss of kidney function due to tissue damage. It affects 10-30 % of hospitalized patients and is independently associated with increased morbidity and mortality. Ischemia-reperfusion injury (IRI) is the most common pathoetiological mechanism of AKI, whereby tissue injury is mediated by reactive oxygen species. Ischemic AKI leads to the rapid upregulation of a transmembrane protein, kidney injury molecule-1 (KIM-1) on the apical membrane of proximal tubular epithelial cells (TECs). Previous work from our group and others demonstrated that the extracellular domain of KIM-1 specifically binds to phosphatidylserine on apoptotic cells, thereby transforming KIM-1-expressing TECs into semi-professional phagocytes for apoptotic corpses. The pathophysiological role of KIM-1 in AKI and relevant signalling mechanisms have not yet been elucidated. Using an in vivo model of AKI in mice genetically deficient in Kim-1, we reveal that Kim-1 expression protects mice from
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ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein...ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein...
Sigma-Aldrich offers abstracts and full-text articles by [Hiroyuki Takatsu, Keiko Baba, Takahiro Shima, Hiroyuki Umino, Utako Kato, Masato Umeda, Kazuhisa Nakayama, Hye-Won Shin].
Health Library | Rutgers Cancer Institute of New JerseyHealth Library | Rutgers Cancer Institute of New Jersey
1. Toffano G, Leon A, Benvegnu D. Effect of brain cortex phospholipids on catechol-amine content of mouse brain. Pharmacol Res Commun. 1976;8:581-590. 2. LaBrake CC, Fung LW. Phospholipid vesicles promote human hemoglobin oxidation. J Biol Chem. 1992;267:16703-16711. 3. Orlando P, Cerrito F, Zirili P. The fate of doubly-labelled brain phospholipids administered to mice. Farmaco. 1975;30:451-458. 4. Gindin J, Novikov M, Kedar D, et al. The effect of plant phosphatidylserine on age-associated memory impairment and mood in the functioning elderly. Geriatric Institute for Education and Research and Dept of Geriatrics; Kaplan Hospital; Rehovot, Israel; 1995.. 5. Crook TH III, Adderly BD. The Memory Cure: The Safe, Scientifically Proven Breakthrough That Can Slow, Halt, Or Even Reverse Age-Related Memory Loss. New York, NY: Pocket Books; 1998:71,72. 6. Gaby AR. Dont believe everything you read. Townsend Letter for Doctors and Patients. May 1997:122-123. 7. Gindin J, Novikov M, Kedar D, et al. The ...
PSOne Classic Games Landing On PS Vita ConsolePSOne Classic Games Landing On PS Vita Console
The new PSone Classic support for Sonys new PS Vita pocket gaming console, will enable users to access, purchase and download games, and you will only need to purchase or already purchase the games once to enjoy playing them on PS3, PSP, or Vita, says Sony
Ubisoft backtracks on claims it lowered AC: Unity resolution on PS4 to achieve Xbox One parity | MCV/DEVELOPUbisoft backtracks on claims it lowered AC: Unity resolution on PS4 to achieve Xbox One parity | MCV/DEVELOP
A developer working on Assassins Creed: Unity has said that the game has been made to run at a reduced resolution of 900p on PS4 to keep it in line with | MCV/DEVELOP
Transport of exogenous fluorescent phosphatidylserine analogue to the Golgi apparatus in cultured fibroblasts. | JCBTransport of exogenous fluorescent phosphatidylserine analogue to the Golgi apparatus in cultured fibroblasts. | JCB
We have examined intracellular transport and metabolism of the fluorescent analogue of phosphatidylserine, 1-palmitoyl-2-(N-[12[(7-nitrobenz-2-oxa-1,3-diazole-4-yl)amino] dodecanoyl])-phosphatidylserine ([palmitoyl-C12-NBD]-PS) in cultured fibroblasts. When monolayer cultures were incubated with liposomes containing (palmitoyl-C12-NBD)-PS at 37 degrees C, fluorescent PS was transported to the Golgi apparatus. NBD-containing analogues of phosphatidylcholine, phosphatidylethanolamine (PE), or phosphatidic acid did not accumulate in the Golgi apparatus under the same experimental conditions. We suggest that the transport is not due to endocytosis, but is the result of incorporation and trans-bilayer movement of the (palmitoyl-C12-NBD)-PS at the plasma membrane followed by translocation of the lipid from plasma membrane to the Golgi apparatus via nonvesicular mechanisms. Uptake of fluorescent PS was inhibited by depletion of cellular ATP and was blocked by structural analogues of the lipid or by ...
This Week in Biotech -- The Motley FoolThis Week in Biotech -- The Motley Fool
Heralding the charge higher was AcelRx Pharmaceuticals (NASDAQ:ACRX) which advanced 18% on the week after disclosing on Tuesday that its post-operative pain management system, Sufentanil NanoTab PCA, met its primary endpoint in late-stage trials and reconfirmed all previous late-stage study results. This data is strong enough for AcelRx to seek approval from the Food and Drug Administration with a new drug application filing expected next quarter. Id be cautious with AcelRx moving forward, as the possibility of an FDA rejection for opioid-based treatments is always a possibility.. Also gaining double digits on the week was the highly embattled Peregrine Pharmaceuticals (NASDAQ:PPHM) which rallied after the FDA approved its late-stage trial design for its second-line non-small-cell lung cancer immunotherapy, Bavituximab. While trial design approvals are rarely big news, it is in this case because mid-stage results for Bavituximab have been all over the place. At first Bavituximab demonstrated a ...
Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks<...Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks<...
TY - JOUR. T1 - Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks. AU - Koutoku, Tomoyuki. AU - Takahashi, Hirokazu. AU - Tomonaga, Shozo. AU - Oikawa, Daichi. AU - Saito, Shin. AU - Tachibana, Tetsuya. AU - Han, Li. AU - Hayamizu, Kohsuke. AU - Denbow, D. Michael. AU - Furuse, Mitsuhiro. PY - 2005/8. Y1 - 2005/8. N2 - The present study investigated whether centrally administered phosphatidylserine (PS) could modify the behavior of chicks under isolation-induced stress. Isolation stress-induced vocalization and spontaneous activity for 10 min, which were attenuated by intracerebroventricular (i.c.v.) injection of PS. The effect of PS was compared with other phospholipids or l-serine, a constituent of PS. Phosphatidylcholine (PC) had no effect on these behavior, but phosphatidylethanolamine (PE) significantly increased vocalizations and spontaneous activity compared with PS. l-Serine similarly decreased isolation-induced vocalizations and ...
September: Ballooning platelets | News | University of BristolSeptember: Ballooning platelets | News | University of Bristol
Platelets play a central role in stopping bleeding (haemostasis) and causing blockages in arteries (arterial thrombosis), particularly in coronary artery disease. At sites of blood vessel damage, they rapidly form aggregates or clumps which are stabilized by the local production of an enzyme called thrombin and generation of a clot of fibrin (a type of protein). Platelets coordinate this local clotting process by exposing a certain type of lipid (fat) called phosphatidylserine (PS) on their cell surface, allowing recruitment of the components of the clotting system that lead to the generation of a clot. This is called a procoagulant surface. The procoagulant activity therefore depends upon the surface area of membrane with exposed PS. In a paper published today in Circulation, Professor Alastair Poole of Bristols School of Physiology and Pharmacology and colleagues show that this surface area is enhanced substantially by the formation of balloon structures from platelets, with subsequent ...
TAM receptors, Phosphatidylserine, inflammation, and Cancer | Cell Communication and Signaling | Full TextTAM receptors, Phosphatidylserine, inflammation, and Cancer | Cell Communication and Signaling | Full Text
The numerous and diverse biological roles of Phosphatidylserine (PtdSer) are featured in this special issue. This review will focus on PtdSer as a cofactor required for stimulating TYRO3, AXL and MERTK - comprising the TAM family of receptor tyrosine kinases by their ligands Protein S (PROS1) and growth-arrest-specific 6 (GAS6) in inflammation and cancer. As PtdSer binding to TAMs is a requirement for their activation, the biological repertoire of PtdSer is now recognized to be broadened to include functions performed by TAMs. These include key homeostatic roles necessary for preserving a healthy steady state in different tissues, controlling inflammation and further additional roles in diseased states and cancer. The impact of PtdSer on inflammation and cancer through TAM signaling is a highly dynamic field of research. This review will focus on PtdSer as a necessary component of the TAM receptor-ligand complex, and for maximal TAM signaling. In particular, interactions between tumor cells and their
Phosphatidylserine (PS) - Nootropics ExpertPhosphatidylserine (PS) - Nootropics Expert
i] De Simone R., Ajmone-Cat M.A., Tirassa P., Minghetti L. "Apoptotic PC12 cells exposing phosphatidylserine promote the production of anti-inflammatory and neuroprotective molecules by microglial cells."Journal of Neuropathology and Experimental Neurology. 2003 Feb;62(2):208-16. (source). [ii] Kosicek M., Hecimovic S. "Phospholipids and Alzheimers Disease: Alterations, Mechanisms and Potential Biomarkers" International Journal of Molecular Science. 2013 Jan; 14(1): 1310-1322. (source). [iii] Crook T.H., Tinklenberg J., Yesavage J., Petrie W., Nunzi M.G., Massari D.C. "Effects of phosphatidylserine in age-associated memory impairment." Neurology. 1991 May;41(5):644-9. (source). [iv] Cunnane S.C., Schneider J.A., Tangney C., Tremblay-Mercier J., Fortier M., Bennett D.A., Morris M.C. "Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimers disease." Journal of Alzheimers Disease. 2012;29(3):691-7. (source). [v] Monteleone P., Beinat L., Tanzillo C., Maj M., Kemali D. ...
Peregrine Pharmaceuticals - WikipediaPeregrine Pharmaceuticals - Wikipedia
Peregrine Pharmaceuticals, Inc. is a publicly-traded American biopharmaceutical company with a portfolio of monoclonal antibodies in clinical trials as potential cancer treatments and diagnostic agents. As of 2016 their lead product candidate was bavituximab. It also has a revenue-generating subsidiary, Avid Bioservices, which is a contract manufacturing organization that provides services to Peregrine and to other companies. Peregrine was founded in 1981. In 2002 Peregrine established a wholly owned subsidiary, Avid Bioservices, a contract manufacturing organization that provides cGMP development and biomanufacturing services for both Peregrine and outside customers. In 2015 Avid had revenues of about $27 million, about 80% of which came under contract from Halozyme Therapeutics. Bavituximab (PGN401) is a human-mouse chimeric monoclonal antibody against phosphatidylserine, which is a component of cell membranes that is exposed when a cell is transformed into solid tumor cancer cell or dies, and ...
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|p|PS 150 features 150 mg of non-soy, sunflower-sourced phosphatidylserine (PS) per capsule. There are no foods rich in PS, so supplementation is essential in order to increase the bodys levels of this brainsupportive nutrient.**|/p||br||p||b|Recommended
Peregrine Pharmaceuticals Reports Financial Results for First Quarter of Fiscal Year 2017 and Recent Developments (NASDAQ:PPHM)Peregrine Pharmaceuticals Reports Financial Results for First Quarter of Fiscal Year 2017 and Recent Developments (NASDAQ:PPHM)
intentions, hopes, beliefs, expectations, representations, projections, plans or predictions of the future are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. The forward-looking statements involve risks and uncertainties including, but not limited to, the risk that one or more of the NCCN grant funded investigator-initiated clinical studies may experience initiation and/or enrollment delays, the risk that data from one or more of the NCCN grant funded investigator-initiated clinical studies does not support the companys current understanding of the potential role of bavituximab in the treatment of various cancers or is otherwise inconclusive, the risk that the final data from the biomarker analysis does not generate any partnership interest, the risk that on-going analysis of SUNRISE trial data, bio-specimen samples and patient characteristics may not identify any subgroup that received clinical benefit from the addition of bavituximab, ...
Peregrine Pharmaceuticals Reports Top-Line and Initial Biomarker Data from Phase III SUNRISE Trial of Bavituximab in Oral...Peregrine Pharmaceuticals Reports Top-Line and Initial Biomarker Data from Phase III SUNRISE Trial of Bavituximab in Oral...
ESMO) 2016 Congress. The presentation included interim efficacy and safety outcomes, as well as initial findings from the companys ongoing biomarker analysis of samples collected during the study. The SUNRISE Phase III trial was discontinued earlier this year based on a pre-specified interim analysis although patient treatment and follow-up in the study were allowed to continue. The pre-planned biomarker analysis has been taking place as patient follow-up has continued and available results were evaluated as part of the recent top-line data analysis. The study protocol pre-specified the collection of thousands of patient samples for exploratory analyses over a wide range of possible biomarkers, including pre-treatment levels of beta-2 glycoprotein-1 (β2GP1). Data presented at ESMO demonstrated that patients with pre-treatment β2GP1 levels between 200 and 240 (representing approximately 30% of randomized patients) achieved a statistically significant, 5.5-month improvement (13.2 months vs. 7.7 ...
Phosphatidylserine | Your Wellbeing NutraceuticalsPhosphatidylserine | Your Wellbeing Nutraceuticals
Phosphatidylserine is used to support brain health and memory. It is also used for stress reduction and is useful for Alzheimers and dementia.
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There are many benefits derived from maintaining good levels of Phosphatidylserine from age-related decline in mental function, improving thinking skills, enhancing mood, and other benefits.
Search Results | RUPSearch Results | RUP
Lipid droplets (LDs) are evolutionarily conserved organelles that play important roles in cellular metabolism. Each LD is enclosed by a monolayer of phospholipids, distinct from bilayer membranes. During LD biogenesis and growth, this monolayer of lipids expands by acquiring phospholipids from the endoplasmic reticulum (ER) through nonvesicular mechanisms. Here, in a mini-screen, we find that ORP5, an integral membrane protein of the ER, can localize to ER-LD contact sites upon oleate loading. ORP5 interacts with LDs through its ligand-binding domain, and ORP5 deficiency enhances neutral lipid synthesis and increases the size of LDs. Importantly, there is significantly more phosphatidylinositol-4-phosphate (PI(4)P) and less phosphatidylserine (PS) on LDs in ORP5-deficient cells than in normal cells. The increased presence of PI(4)P on LDs in ORP5-deficient cells requires phosphatidylinositol 4-kinase 2-α. Our results thus demonstrate the existence of PI(4)P on LDs and suggest that LD-associated ...
Frozen Synapse Prime Launches On PS Vita On September 23 | Gaming UnionFrozen Synapse Prime Launches On PS Vita On September 23 | Gaming Union
Sony has announced that Frozen Synapse Prime, the PS Vita version of Frozen Synapse, will launch on the 23rd of September in both North America and Europe. In addition, the games soundtrack will…
Profit Sharing and Gainsharing: A Review of Theory, Incidence, and EffectsProfit Sharing and Gainsharing: A Review of Theory, Incidence, and Effects
Downloadable! The slowdown in productivity growth since the 1970s has led to increased interest in alternative compensation schemes-such as profit sharing and gainsharing-that might raise worker productivity and reduce turnover. In this working paper, Jones, Kato, and Pliskin summarize the rise in popularity of profit sharing (PS) and gainsharing (GS) plans; review existing theoretical and empirical work on PS and GS; and highlight findings that relate the effectiveness of such programs at raising productivity and enhancing employment stability. They also note that some existing studies contain some econometric problems relating to plan and model variables; there are measurement problems as well. Their paper primarily focuses on PS plans.(This abstract was borrowed from another version of this item.)
Gadget : Black Ops III on PS4 this monthGadget : Black Ops III on PS4 this month
Eclipse also sets the stage for Zetsubou No Shima, the highly-anticipated, all-new entry in the Call of Duty: Black Ops III Zombies storyline that spans the four DLC Map Packs for Black Ops III this year. The Origins characters continue on their mission to stop the zombie apocalypse not only in this universe but in all universes. Our heroes find themselves stranded on a remote Pacific island which is home to the Division 9 facility: a secret biological research lab whose experiments with Element 115 and its effects on human, animal, and plant biology has created horrors beyond belief. Zetsubou No Shima features a foliage rich island map including new terrifying zombie enemies, a variety of innovative transport mechanics, more devastating traps and classic Zombies side quests.. The Call of Duty: Black Ops III Eclipse DLC Map Pack is available at a discounted rate via the Call of Duty: Black Ops III DLC Season Pass, which features four DLC Map Packs planned for the year.. ...
Preclinical Study Presented at AACR Annual Meeting Shows Broad Anti-Cancer Potential of Peregrines anti-PS Vascular Targeting...Preclinical Study Presented at AACR Annual Meeting Shows Broad Anti-Cancer Potential of Peregrine's anti-PS Vascular Targeting...
-Combination of a Bavituximab Equivalent and an Agent that Re-Activates the Tumor Suppressor P53 Inhibited Tumor Growth Synergistically in Preclinical Breast Ca
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PHOSPHATIDYLSERINE - Progressive NutracarePHOSPHATIDYLSERINE - Progressive Nutracare
Phosphatydylserine is used to support memory and cognitive function in individuals with mild to moderate faulty memory due to age. Has been reported to maintain the structure and functioning of brain cells, as well as to improve memory, learning, concentration, word recall, and mood in middle-aged and elderly persons w
Armored Core V gets new January release for Japan | VG247Armored Core V gets new January release for Japan | VG247
From Softwares announced its releasing Armored Core V on January 26 for ¥7,800 in Japan on PS3 and Xbox 360. The mech title was suposed to lau…
Jadwal Pendaftaran dan Pelaksanaan UAS Ganjil TA. 2016-2017 - Fakultas Ilmu Seni dan Sastra | Universitas PasundanJadwal Pendaftaran dan Pelaksanaan UAS Ganjil TA. 2016-2017 - Fakultas Ilmu Seni dan Sastra | Universitas Pasundan
Diberitahukan Kepada Seluruh Mahasiswa/i Fakultas Ilmu Seni dan Sastra Universitas Pasundan Bandung.. Bahwa Ujian Akhir Semester (UAS) Semester Ganjil Tahun Akademik 2016-2017, akan dilaksanakan pada tanggal 16 - 27 Januari 2017,. Aktivasi / Cetak Kartu ujian secara online di akademik.unpas.ac.id dimulai Tanggal 26 Desember 2016 sampai 06 Januari 2017.. Adapun Pelaksanaan ujian dilaksanakan sesuai Jadwal Perkuliahan Reguler dengan pembagian minggu berdasarkan sifat ujian ( Untuk Jadwal Penggunaan Ruangan Harap diperhatikan). dengan persyaratan Telah Membayar DPP Minimal 75 % dan DPPS 75 % Tahun Akademik 2016/2017.. Demikian Pengumuman ini, Harap Diperhatikan.. ...
PhosSerine Complex 90 gels | NutriCologyPhosSerine Complex 90 gels | NutriCology
Phosphatidylserine is a phospholipid contained in all cell membranes. It is a smaller component of lecithin than phosphatidylcholine
CortisolCortisol
ApoptosisApoptosis
Immune tolerance in pregnancyImmune tolerance in pregnancy
PISD (gene)PISD (gene)
Red blood cellRed blood cell
Cross-presentationCross-presentation
Phospholipid scramblasePhospholipid scramblase
Phospholipase A1Phospholipase A1
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GeldanamycinGeldanamycin
SheddaseSheddase
Κατάθλιψη - ΒικιπαίδειαΚατάθλιψη - Βικιπαίδεια
Lipid bilayerLipid bilayer
ApoptosisApoptosis
SDPRSDPR
Dual-polarization interferometryDual-polarization interferometry
PhagocytePhagocyte
JMJD6JMJD6
L-serine-phosphatidylethanolamine phosphatidyltransferaseL-serine-phosphatidylethanolamine phosphatidyltransferase
Fluid mosaic modelFluid mosaic model
CDP-diacylglycerol-serine O-phosphatidyltransferaseCDP-diacylglycerol-serine O-phosphatidyltransferase
PhosphatidylethanolaminePhosphatidylethanolamine
AnnexinAnnexin
Hemolytic anemiaHemolytic anemia
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HAVCR1HAVCR1
AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
PhosphatidylserinesAnnexin A5CDPdiacylglycerol-Serine O-PhosphatidyltransferaseApoptosisPhagocytosisPhospholipidsCell MembranePhosphatidylethanolaminesHydrocortisoneMembrane LipidsFatigue Syndrome, ChronicAppetiteSleepFatigueSkinParasympathetic Nervous SystemCircadian RhythmExerciseSalivaSleep, REMLongevityThiamin PyrophosphokinaseCaloric RestrictionLife ExpectancyHistamine ReleaseEthanolamineCompulsive BehaviorWeight LiftingEgg YolkSubarachnoid HemorrhageJumonji Domain-Containing Histone DemethylasesUmbilical VeinsReceptors, Cell SurfaceInfarction, Middle Cerebral ArteryBrain IschemiaNeurologyMemoryNeuropsychological TestsMemory DisordersCognition DisordersMemory, Short-TermAnnexin A2Annexin A1Annexin A6Annexin A4Fatty Acids, EssentialDocosahexaenoic AcidsFatty AcidsAscorbic Acid DeficiencyFatty Acids, UnsaturatedElectronic MailSpectrophotometry, InfraredSpectroscopy, Fourier Transform InfraredPeriodicals as TopicJournal Impact FactorPublishing
PHOSPHATIDYLSERINE: Uses, Side Effects, Interactions and Warnings - WebMDPHOSPHATIDYLSERINE: Uses, Side Effects, Interactions and Warnings - WebMD
Phosphatidylserine & Cortisol | LIVESTRONG.COMPhosphatidylserine & Cortisol | LIVESTRONG.COM
7 OH And Phosphatidylserine - AnabolicMinds.com7 OH And Phosphatidylserine - AnabolicMinds.com
Phosphatidyl Serine - Bodybuilding.comPhosphatidyl Serine - Bodybuilding.com
Abstract 19922: Phosphatidylserine Receptor Upregulation in Stroke for Targeted Carrier Delivery | CirculationAbstract 19922: Phosphatidylserine Receptor Upregulation in Stroke for Targeted Carrier Delivery | Circulation
Infrared spectra of brain phosphatidylserine | Biochemical JournalInfrared spectra of brain phosphatidylserine | Biochemical Journal
PhosphatidylSerine - Soy-free, non-GMO Sharp-PS® GREEN for Memory, Focus, MoodPhosphatidylSerine - Soy-free, non-GMO Sharp-PS® GREEN for Memory, Focus, Mood
Phosphatidylserine - Supplements - Nutrition ExpressPhosphatidylserine - Supplements - Nutrition Express
Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammationPhosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation
Inserm - Microbubble-Assisted Ultrasound-Induced Transient Phosphatidylserine TranslocationInserm - Microbubble-Assisted Ultrasound-Induced Transient Phosphatidylserine Translocation
Phosphatidylserine Apoptosis Kit (Green Fluorescence 405) Kit-0744 - Creative BioMartPhosphatidylserine Apoptosis Kit (Green Fluorescence 405) Kit-0744 - Creative BioMart
Phosphatidylserine - WikipediaPhosphatidylserine - Wikipedia
Phosphatidylserine decarboxylase - WikipediaPhosphatidylserine decarboxylase - Wikipedia
Phosphatidylserine: Side Effects, Dosages, Treatment, Interactions, WarningsPhosphatidylserine: Side Effects, Dosages, Treatment, Interactions, Warnings
Phosphatidylserine Powder - Chemical & PharmaceuticalsPhosphatidylserine Powder - Chemical & Pharmaceuticals
Phosphatidylserine - Health LibraryPhosphatidylserine - Health Library
Effects of phosphatidylserine in age-associated memory impairmentEffects of phosphatidylserine in age-associated memory impairment
PhosphatidylserinePhosphatidylserine
Phosphatidylserine externalization, necroptotic bodies release, and phagocytosis during necroptosis. - PubMed - NCBIPhosphatidylserine externalization, "necroptotic bodies" release, and phagocytosis during necroptosis. - PubMed - NCBI
ExRx.net • View topic - phosphatidylserine/cortisol blockersExRx.net • View topic - phosphatidylserine/cortisol blockers
Phosphatidylserine | GreenMedInfo | Substance | Natural MedicinePhosphatidylserine | GreenMedInfo | Substance | Natural Medicine
Sensors | Free Full-Text | Sensing Phosphatidylserine in Cellular Membranes | NotesSensors | Free Full-Text | Sensing Phosphatidylserine in Cellular Membranes | Notes
In vivo detection and imaging of phosphatidylserine expression during programmed cell death | PNASIn vivo detection and imaging of phosphatidylserine expression during programmed cell death | PNAS
A receptor for phosphatidylserine-specific clearance of apoptotic cells. - PubMed - NCBIA receptor for phosphatidylserine-specific clearance of apoptotic cells. - PubMed - NCBI
Phosphatidyl serine | C13H24NO10P - PubChemPhosphatidyl serine | C13H24NO10P - PubChem
ExRx.net • View topic - phosphatidylserine to help switch offExRx.net • View topic - phosphatidylserine to help 'switch off'
Natures Way Phosphatidyl-Serine at Netrition.com.Nature's Way Phosphatidyl-Serine at Netrition.com.
Phosphatidylserine | definition of phosphatidylserine by Medical dictionaryPhosphatidylserine | definition of phosphatidylserine by Medical dictionary
Phosphatidyl SerinePhosphatidyl Serine
NIOSHTIC-2 Publications Search - 20020712 - Oxidative signaling pathway for externalization of plasma membrane...NIOSHTIC-2 Publications Search - 20020712 - Oxidative signaling pathway for externalization of plasma membrane...
PTDSS2 - Phosphatidylserine synthase 2 - Homo sapiens (Human) - PTDSS2 gene & proteinPTDSS2 - Phosphatidylserine synthase 2 - Homo sapiens (Human) - PTDSS2 gene & protein
Neuronal specific increase of phosphatidylserine by docosahexaenoic acid.Neuronal specific increase of phosphatidylserine by docosahexaenoic acid.
Life Extension Phosphatidyl Serine - eVitamins.comLife Extension Phosphatidyl Serine - eVitamins.com
phosphatidyl serinephosphatidyl serine
Carlson Labs Phosphatidyl Serine - eVitamins AustraliaCarlson Labs Phosphatidyl Serine - eVitamins Australia
Now Foods, Extra Strength Phosphatidyl Serine, 300 mg, 50 Softgels - iHerbNow Foods, Extra Strength Phosphatidyl Serine, 300 mg, 50 Softgels - iHerb
Read detailed descriptionRead detailed description
AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
PhosphatidylserinesAnnexin A5CDPdiacylglycerol-Serine O-PhosphatidyltransferaseApoptosisPhagocytosisPhospholipidsCell MembranePhosphatidylethanolaminesHydrocortisoneMembrane LipidsFatigue Syndrome, ChronicAppetiteSleepFatigueSkinParasympathetic Nervous SystemCircadian RhythmExerciseSalivaSleep, REMLongevityThiamin PyrophosphokinaseCaloric RestrictionLife ExpectancyHistamine ReleaseEthanolamineCompulsive BehaviorWeight LiftingEgg YolkSubarachnoid HemorrhageJumonji Domain-Containing Histone DemethylasesUmbilical VeinsReceptors, Cell SurfaceInfarction, Middle Cerebral ArteryBrain IschemiaNeurologyMemoryNeuropsychological TestsMemory DisordersCognition DisordersMemory, Short-TermAnnexin A2Annexin A1Annexin A6Annexin A4Fatty Acids, EssentialDocosahexaenoic AcidsFatty AcidsAscorbic Acid DeficiencyFatty Acids, UnsaturatedElectronic MailSpectrophotometry, InfraredSpectroscopy, Fourier Transform InfraredPeriodicals as TopicJournal Impact FactorPublishing
PhospholipidPhosphatidyl SerineAntibodiesPhospholipidsApoptosisApoptoticSignal transductionSupplementsTranslocationAnti-phosphatidylserineSupplemental PhosphatidylSerineCortisolSupplementationBrainDosageSoybean-derivedSunflowerSupplementComplexAcetylcholineBovineMemoryStressPowderSharp-PSCellLevelsNutrientEffectiveness
Phospholipid10
Phosphatidyl Serine2
Antibodies1
  • Phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) were strongly correlated with the presence of lupus anticoagulant showing a high specificity for the diagnosis of antiphospholipid syndrome. (elsevier.com)
Phospholipids4
Apoptosis5
Apoptotic1
Signal transduction1
Supplements5
Translocation1
  • Non-Radioactive: No special requirements for waste treatment.Convenient: All essential assay components are included.Optimized Performance: Provide optimal conditions for detecting the translocation of phosphatidylserine.Enhanced Value: Less expensive than the sum of individual components. (creativebiomart.net)
Anti-phosphatidylserine1
Supplemental PhosphatidylSerine2
Cortisol7
Supplementation3
Brain6
Dosage1
Soybean-derived1
Sunflower2
Supplement1
Complex1
  • PuriSure's Phosphatidylserine can be safely added to any complex you desire as it is free of animal products, derived from soy, and is both vegetarian and vegan friendly. (purisure.com)
Acetylcholine1
Bovine2
Memory3
Stress3
Powder1
Sharp-PS1
Cell1
Levels1
Nutrient2
Effectiveness1
Frontiers | Interleaflet Coupling, Pinning, and Leaflet Asymmetry-Major Players in Plasma Membrane Nanodomain Formation | Cell...
Frontiers | Interleaflet Coupling, Pinning, and Leaflet Asymmetry-Major Players in Plasma Membrane Nanodomain Formation | Cell... (frontiersin.org)
Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiprothrombin antibodies...
Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiprothrombin antibodies... (keio.pure.elsevier.com)
Externalization of phosphatidylserine may not be an early signal of apoptosis in neuronal cells, but only the...
Externalization of phosphatidylserine may not be an early signal of apoptosis in neuronal cells, but only the... (researchwithrutgers.com)
Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia | Disease Models & Mechanisms
Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia | Disease Models & Mechanisms (dmm.biologists.org)
Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.com
Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.com (patents.com)
Human Metabolome Database: Showing metabocard for PS(14:0/14:0) (HMDB0012330)
Human Metabolome Database: Showing metabocard for PS(14:0/14:0) (HMDB0012330) (hmdb.ca)
Lipid - Wikipedia
Lipid - Wikipedia (en.wikipedia.org)
PS- and PSR-mediated uptake of apoptotic cells occurs b | Open-i
PS- and PSR-mediated uptake of apoptotic cells occurs b | Open-i (openi.nlm.nih.gov)
Chemical Aspects of Neuronal Information Transmission in Synapses | SpringerLink
Chemical Aspects of Neuronal Information Transmission in Synapses | SpringerLink (link.springer.com)
Benefits Of Soy Lecithin- Gaspari Nutrition
Benefits Of Soy Lecithin- Gaspari Nutrition (gasparinutrition.com)
Solid-State NMR Study of Drug Interaction with Phospholipid Bilayers Chlorpromazine, olanzapine and articaine interacting with...
Solid-State NMR Study of Drug Interaction with Phospholipid Bilayers Chlorpromazine, olanzapine and articaine interacting with... (bora.uib.no)
Rapid evaporative ionisation mass spectrometry of electrosurgical vapours for the identification of breast pathology: towards...
Rapid evaporative ionisation mass spectrometry of electrosurgical vapours for the identification of breast pathology: towards... (breast-cancer-research.biomedcentral.com)
Frontiers | Metabolome and Lipidome Profiles of Populus × canescens Twig Tissues During Annual Growth Show Phospholipid-Linked...
Frontiers | Metabolome and Lipidome Profiles of Populus × canescens Twig Tissues During Annual Growth Show Phospholipid-Linked... (frontiersin.org)
In situ biomarker discovery and label-free molecular histopathological diagnosis of lung cancer by ambient mass spectrometry...
In situ biomarker discovery and label-free molecular histopathological diagnosis of lung cancer by ambient mass spectrometry... (nature.com)
Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor | Nature Communications
Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor | Nature Communications (nature.com)
Synthesis of Stereoisomeric Phospholipids for Use in Membrane Studies | SpringerLink
Synthesis of Stereoisomeric Phospholipids for Use in Membrane Studies | SpringerLink (link.springer.com)
Welcome to CDC stacks
Welcome to CDC stacks (stacks.cdc.gov)
Oleksandr O Kapralov<...
Oleksandr O Kapralov<... (publichealth.pitt.edu)
Community Academic Profiles - Faculty & Researchers - Stanford Medicine
Community Academic Profiles - Faculty & Researchers - Stanford Medicine (med.stanford.edu)
Jun Wang - Research Output - Northwestern Scholars
Jun Wang - Research Output - Northwestern Scholars (scholars.northwestern.edu)
ISOLATION AND CHARACTERIZATION OF LAMELLAR BODIES AND TUBULAR MYELIN FROM RAT LUNG HOMOGENATES | JCB
ISOLATION AND CHARACTERIZATION OF LAMELLAR BODIES AND TUBULAR MYELIN FROM RAT LUNG HOMOGENATES | JCB (jcb.rupress.org)
Cord Serum Lipidome in Prediction of Islet Autoimmunity and Type 1 Diabetes | Diabetes
Cord Serum Lipidome in Prediction of Islet Autoimmunity and Type 1 Diabetes | Diabetes (diabetes.diabetesjournals.org)