AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureHealth Care
PhosphatidylcholinesCalorimetry, Differential ScanningLipid BilayersGlycerylphosphorylcholineMolecular ConformationPhospholipidsAtrial SeptumBiophysical Phenomena1,2-DipalmitoylphosphatidylcholineBiophysicsThermodynamicsDimyristoylphosphatidylcholinePhosphatidylethanolaminesGelsMembranes, ArtificialAcylationMembrane FluidityLiposomesX-Ray DiffractionMembrane LipidsEgg YolkMagnetic Resonance SpectroscopyFatty Acids, UnsaturatedMolecular StructureStructure-Activity RelationshipLysophosphatidylcholinesDeuteriumTemperatureCholesterolStearic AcidsMicellesFatty AcidsIsomerismPhysicochemical PhenomenaFluorescence PolarizationPhosphatidylcholine-Sterol O-AcyltransferasePulmonary SurfactantsChemistry, PhysicalPhase TransitionPhospholipid EthersFatty Acids, MonounsaturatedChromatography, Thin LayerPhospholipases AKineticsMembranesModels, ChemicalPhosphatidic AcidsMass SpectrometryPhospholipid Transfer ProteinsPressureOxidation-ReductionPlatelet Activating FactorChromatography, High Pressure LiquidSpectroscopy, Fourier Transform InfraredWaterCholineSurface PropertiesPhosphatidylglycerolsDiglyceridesSpectrometry, FluorescenceElectron Spin Resonance SpectroscopyPhospholipases A2LipidsLipoproteins, HDLFluorescent DyesCattleEthanolHydrolysisLiverSubstrate SpecificityModels, BiologicalLipoproteins, LDLMicroscopy, ElectronModels, MolecularCell Membrane
Phosphatidylcholines
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.
Calorimetry, Differential Scanning
Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.
Lipid Bilayers
Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.
Glycerylphosphorylcholine
A component of PHOSPHATIDYLCHOLINES or LECITHINS, in which the two hydroxy groups of GLYCEROL are esterified with fatty acids. (From Stedman, 26th ed) It counteracts the effects of urea on enzymes and other macromolecules.
Molecular Conformation
The characteristic three-dimensional shape of a molecule.
Phospholipids
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Atrial Septum
The thin membrane-like muscular structure separating the right and the left upper chambers (HEART ATRIA) of a heart.
Biophysical Phenomena
The physical characteristics and processes of biological systems.
1,2-Dipalmitoylphosphatidylcholine
Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.
Biophysics
The study of PHYSICAL PHENOMENA and PHYSICAL PROCESSES as applied to living things.
Thermodynamics
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Dimyristoylphosphatidylcholine
A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes.
Phosphatidylethanolamines
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids.
Gels
Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.
Membranes, Artificial
Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.
Acylation
The addition of an organic acid radical into a molecule.
Membrane Fluidity
The motion of phospholipid molecules within the lipid bilayer, dependent on the classes of phospholipids present, their fatty acid composition and degree of unsaturation of the acyl chains, the cholesterol concentration, and temperature.
Liposomes
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
X-Ray Diffraction
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Membrane Lipids
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
Egg Yolk
Cytoplasm stored in an egg that contains nutritional reserves for the developing embryo. It is rich in polysaccharides, lipids, and proteins.
Magnetic Resonance Spectroscopy
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Fatty Acids, Unsaturated
FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.
Molecular Structure
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Structure-Activity Relationship
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Lysophosphatidylcholines
Derivatives of PHOSPHATIDYLCHOLINES obtained by their partial hydrolysis which removes one of the fatty acid moieties.
Deuterium
Deuterium. The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.
Temperature
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Cholesterol
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Stearic Acids
A group of compounds that are derivatives of octadecanoic acid which is one of the most abundant fatty acids found in animal lipids. (Stedman, 25th ed)
Micelles
Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
Fatty Acids
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
Isomerism
The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Physicochemical Phenomena
The physical phenomena describing the structure and properties of atoms and molecules, and their reaction and interaction processes.
Fluorescence Polarization
Measurement of the polarization of fluorescent light from solutions or microscopic specimens. It is used to provide information concerning molecular size, shape, and conformation, molecular anisotropy, electronic energy transfer, molecular interaction, including dye and coenzyme binding, and the antigen-antibody reaction.
Phosphatidylcholine-Sterol O-Acyltransferase
An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. EC 2.3.1.43.
Pulmonary Surfactants
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
Chemistry, Physical
The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes.
Phase Transition
A change of a substance from one form or state to another.
Phospholipid Ethers
Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.
Fatty Acids, Monounsaturated
Fatty acids which are unsaturated in only one position.
Chromatography, Thin Layer
Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Phospholipases A
Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates.
Kinetics
The rate dynamics in chemical or physical systems.
Membranes
Thin layers of tissue which cover parts of the body, separate adjacent cavities, or connect adjacent structures.
Models, Chemical
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
Phosphatidic Acids
Fatty acid derivatives of glycerophosphates. They are composed of glycerol bound in ester linkage with 1 mole of phosphoric acid at the terminal 3-hydroxyl group and with 2 moles of fatty acids at the other two hydroxyl groups.
Mass Spectrometry
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Phospholipid Transfer Proteins
A ubiquitous family of proteins that transport PHOSPHOLIPIDS such as PHOSPHATIDYLINOSITOL and PHOSPHATIDYLCHOLINE between membranes. They play an important role in phospholipid metabolism during vesicular transport and SIGNAL TRANSDUCTION.
Pressure
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Platelet Activating Factor
A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.
Chromatography, High Pressure Liquid
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Spectroscopy, Fourier Transform Infrared
A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.
Water
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Choline
A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
Surface Properties
Characteristics or attributes of the outer boundaries of objects, including molecules.
Phosphatidylglycerols
A nitrogen-free class of lipids present in animal and particularly plant tissues and composed of one mole of glycerol and 1 or 2 moles of phosphatidic acid. Members of this group differ from one another in the nature of the fatty acids released on hydrolysis.
Diglycerides
Spectrometry, Fluorescence
Measurement of the intensity and quality of fluorescence.
Electron Spin Resonance Spectroscopy
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
Phospholipases A2
Phospholipases that hydrolyze the acyl group attached to the 2-position of PHOSPHOGLYCERIDES.
Lipids
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Lipoproteins, HDL
A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.
Fluorescent Dyes
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
Cattle
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Ethanol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Hydrolysis
The process of cleaving a chemical compound by the addition of a molecule of water.
Liver
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Substrate Specificity
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Models, Biological
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Lipoproteins, LDL
A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.
Microscopy, Electron
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Models, Molecular
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Cell Membrane
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

Dietary control of triglyceride and phospholipid synthesis in rat liver slices. (1/6517)

1. The effect of dietary manipulation on the synthesis of triglycerides and phospholipids was investigated by determining the incorporation of labeled long-chain fatty acid or glycerol into these lipids in liver slices derived from normally fed, fasted, and fat-free refed rats. 2. Triglyceride synthesis was affected markedly by the dietary regime of the animal; the lowest rates were measured with fasted rats, and the highest ones with fat-free refed rats. 3. In contrast to triglyceride synthesis, phospholipid synthesis occured at virtually constant rates regardless of the dietary conditions. 4. Addition of large amounts of fatty acid to the incubation mixture resulted in a marked stimulation of triglyceride synthesis, whereas phospholipid synthesis was affected to a much smaller extent. 5. These results indicate that the synthesis of triglycerides and that of phospholipids are controlled independently, and that the availability of fatty acid in the cell contributes to the control of triglyceride synthesis.  (+info)

Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation. (2/6517)

Blocking protein C binding to the endothelial cell protein C receptor (EPCR) on the endothelium is known to reduce protein C activation rates. Now we isolate human EPCR and thrombomodulin (TM) and reconstitute them into phosphatidylcholine vesicles. The EPCR increases protein C activation rates in a concentration-dependent fashion that does not saturate at 14 EPCR molecules/TM. Without EPCR, the protein C concentration dependence fits a single class of sites (Km = 2.17 +/- 0.13 microM). With EPCR, two classes of sites are apparent (Km = 20 +/- 15 nM and Km = 3.2 +/- 1.7 microM). Increasing the EPCR concentration at a constant TM concentration increases the percentage of high affinity sites. Holding the TM:EPCR ratio constant while decreasing the density of these proteins results in a decrease in the EPCR enhancement of protein C activation, suggesting that there is little affinity of the EPCR for TM. Negatively charged phospholipids also enhance protein C activation. EPCR acceleration of protein C activation is blocked by anti-EPCR antibodies, but not by annexin V, whereas the reverse is true with negatively charged phospholipids. Human umbilical cord endothelium expresses approximately 7 times more EPCR than TM. Anti-EPCR antibody reduces protein C activation rates 7-fold over these cells, whereas annexin V is ineffective, indicating that EPCR rather than negatively charged phospholipid provide the surface for protein C activation. EPCR expression varies dramatically among vascular beds. The present results indicate that the EPCR concentration will determine the effectiveness of the protein C activation complex.  (+info)

Molecular dynamics on a model for nascent high-density lipoprotein: role of salt bridges. (3/6517)

The results of an all-atom molecular dynamics simulation on a discoidal complex made of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and a synthetic alpha-helical 18-mer peptide with an apolipoprotein-like charge distribution are presented. The system consists of 12 acetyl-18A-amide (Ac-18A-NH2) (. J. Biol. Chem. 260:10248-10255) molecules and 20 molecules of POPC in a bilayer, 10 in each leaflet, solvated in a sphere of water for a total of 28,522 atoms. The peptide molecules are oriented with their long axes normal to the bilayer (the "picket fence" orientation). This system is analogous to complexes formed in nascent high-density lipoprotein and to Ac-18A-NH2/phospholipid complexes observed experimentally. The simulation extended over 700 ps, with the last 493 ps used for analysis. The symmetry of this system allows for averaging over different helices to improve sampling, while maintaining explicit all-atom representation of all peptides. The complex is stable on the simulated time scale. Several possible salt bridges between and within helices were studied. A few salt bridge formations and disruptions were observed. Salt bridges provide specificity in interhelical interactions.  (+info)

Morphological behavior of acidic and neutral liposomes induced by basic amphiphilic alpha-helical peptides with systematically varied hydrophobic-hydrophilic balance. (4/6517)

Lipid-peptide interaction has been investigated using cationic amphiphilic alpha-helical peptides and systematically varying their hydrophobic-hydrophilic balance (HHB). The influence of the peptides on neutral and acidic liposomes was examined by 1) Trp fluorescence quenched by brominated phospholipid, 2) membrane-clearing ability, 3) size determination of liposomes by dynamic light scattering, 4) morphological observation by electron microscopy, and 5) ability to form planar lipid bilayers from channels. The peptides examined consist of hydrophobic Leu and hydrophilic Lys residues with ratios 13:5, 11:7, 9:9, 7:11, and 5:13 (abbreviated as Hels 13-5, 11-7, 9-9, 7-11, and 5-13, respectively; Kiyota, T., S. Lee, and G. Sugihara. 1996. Biochemistry. 35:13196-13204). The most hydrophobic peptide (Hel 13-5) induced a twisted ribbon-like fibril structure for egg PC liposomes. In a 3/1 (egg PC/egg PG) lipid mixture, Hel 13-5 addition caused fusion of the liposomes. Hel 13-5 formed ion channels in neutral lipid bilayer (egg PE/egg PC = 7/3) at low peptide concentrations, but not in an acidic bilayer (egg PE/brain PS = 7/3). The peptides with hydrophobicity less than Hel 13-5 (Hels 11-7 and Hel 9-9) were able to partially immerse their hydrophobic part of the amphiphilic helix in lipid bilayers and fragment liposome to small bicelles or micelles, and then the bicelles aggregated to form a larger assembly. Peptides Hel 11-7 and Hel 9-9 each formed strong ion channels. Peptides (Hel 7-11 and Hel 5-13) with a more hydrophilic HHB interacted with an acidic lipid bilayer by charge interaction, in which the former immerses the hydrophobic part in lipid bilayer, and the latter did not immerse, and formed large assemblies by aggregation of original liposomes. The present study clearly showed that hydrophobic-hydrophilic balance of a peptide is a crucial factor in understanding lipid-peptide interactions.  (+info)

Localization and environment of tryptophans in soluble and membrane-bound states of a pore-forming toxin from Staphylococcus aureus. (5/6517)

The location and environment of tryptophans in the soluble and membrane-bound forms of Staphylococcus aureus alpha-toxin were monitored using intrinsic tryptophan fluorescence. Fluorescence quenching of the toxin monomer in solution indicated varying degrees of tryptophan burial within the protein interior. N-Bromosuccinimide readily abolished 80% of the fluorescence in solution. The residual fluorescence of the modified toxin showed a blue-shifted emission maximum, a longer fluorescence lifetime as compared to the unmodified and membrane-bound alpha-toxin, and a 5- to 6-nm red edge excitation shift, all indicating a restricted tryptophan environment and deeply buried tryptophans. In the membrane-bound form, the fluorescence of alpha-toxin was quenched by iodide, indicating a conformational change leading to exposure of some tryptophans. A shorter average lifetime of tryptophans in the membrane-bound alpha-toxin as compared to the native toxin supported the conclusions based on iodide quenching of the membrane-bound toxin. Fluorescence quenching of membrane-bound alpha-toxin using brominated and spin-labeled fatty acids showed no quenching of fluorescence using brominated lipids. However, significant quenching was observed using 5- and 12-doxyl stearic acids. An average depth calculation using the parallax method indicated that the doxyl-quenchable tryptophans are located at an average depth of 10 A from the center of the bilayer close to the membrane interface. This was found to be in striking agreement with the recently described structure of the membrane-bound form of alpha-toxin.  (+info)

Platelet high affinity low density lipoprotein binding and import of lipoprotein derived phospholipids. (6/6517)

The binding of low density lipoprotein (LDL) to the platelet cell membrane could facilitate the transfer of phospholipids from LDL to the platelets. A polyclonal antibody against the platelet glycoproteins IIb/IIIa inhibited the high affinity binding of 125I-LDL by up to 80%. The transfer of pyrene (py)-labeled sphingomyelin (SM), phosphatidylcholine and phosphatidylethanolamine from LDL to the platelets was unaffected by the antibody. The lectin wheat germ agglutinin (WGA) reduced the binding of 125I-LDL to the platelets by approximately 80%. In contrast, the lectin stimulated the transfer of SM from LDL into the platelets by about three-fold. WGA also specifically augmented the transfer of py-SM between lipid vesicles and the platelets, the stimulation being abolished in the presence of N-acetylglucosamine. Dextran sulfate (DS) increased the specific binding of 125I-LDL to the platelets by up to 2.8-fold. On the other hand, the import of LDL-derived py-phospholipids was unaffected by DS. Together, the results indicate that the phospholipid transfer from LDL to the platelets is independent of the high affinity LDL binding to the platelets and is specifically stimulated by WGA. Thus, the interactions of platelets with LDL phospholipids differ markedly from those with the apoprotein components of the lipoproteins.  (+info)

Phospholipid-subclass-specific partitioning of lipophilic ions in membrane-water systems. (7/6517)

Herein, we systematically investigate phospholipid-subclass-specific alterations in the partitioning of both cationic and anionic amphiphiles to identify the importance of ester, ether and vinyl ether linkages at the sn-1 position of phospholipids in the partitioning of charged amphiphiles. The results demonstrated that the membrane-water partition coefficient of a prototypic cationic amphiphile (i.e. 3,3'-dipropylthiadicarbocyanine iodide) was approximately 2.5 times higher in membranes comprised of plasmenylcholine in comparison with membranes comprised of either phosphatidylcholine or plasmanylcholine. In striking contrast, the membrane-water partition coefficient of a prototypic anionic amphiphile [i.e. bis-(1,3-dibutylbarbituric acid)trimethine oxonol] in membranes comprised of plasmenylcholine was approximately 2.5 times lower than that manifest in membranes comprised of phosphatidylcholine or plasmanylcholine. Utilizing theseexperimentally determined partition coefficients,the relative membrane dipole potential of membranes comprised of plasmenylcholine was calculated and found to be approximately 25 mV lower than in membranes comprised of phosphatidylcholine or plasmanylcholine. This lower membrane dipole potential in membranes comprised of plasmenylcholine is equivalent to the membrane potential induced by incorporation of approximately 25 mol% of anionic phospholipids in membranes comprised of phosphatidylcholine. Collectively, these results demonstrate that phospholipid-subclass-specific differences in the membrane dipole potential contribute to alterations in the partitioning of lipophilic ions in membrane bilayers comprised of distinct phospholipid subclasses. Moreover, they suggest that these physicochemical differences can be exploited to facilitate the targeting of charged lipophilic drugs to specific cells and subcellular membrane compartments.  (+info)

Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites. (8/6517)

Antibodies to phosphatidylcholine (PtC), a common constituent of mammalian and bacterial cell membranes, represent a large proportion of the natural antibody repertoire in mice. Previous studies of several mouse strains (e.g., C57BL/6) have shown that anti-PtC antibodies are mainly encoded by the VH11 and VH12 immunoglobulin heavy chain variable region gene families. We show here, however, that VH11 and VH12 encode only a small proportion of the anti-PtC antibodies in BALB/c mice. Instead, VHQ52-encoded antibodies predominate in this strain. In addition, two-thirds of the cells expressing VHQ52 family genes use a single gene (which, interestingly, has been previously shown to predominate in the anti-oxazolone response). We also show here that in anti-PtC antibodies from all strains, the distinctive antigen-binding sites associated with VHQ52 differ substantially from those associated with VH11 and VH12. That is, VHQ52-containing transcripts preferentially use the joining region JH4 rather than JH1 and exhibit more diverse complementarity-determining region 3 (CDR3) junctions with more N-region nucleotide additions at the gene segment junctions. Thus, the VH gene family that predominates in the anti-PtC repertoire differs among mouse strains, whereas the distinctive VHDJH rearrangements (CDR3, JH) associated with each VH gene family are similar in all strains. We discuss these findings in the context of a recent hypothesis suggesting that CDR3 structure, independent of VH framework, is sufficient to define the specificity of an antibody.  (+info)

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Egg phosphatidylcholine is used to improve liver functionality and enhance the functioning of digestive system in elderly people. Increasing old age population is expected to drive the market growth. Moreover, egg phosphatidylcholine is used as means of relief for food allergies which in turn is expected to drive demand in dietary supplements. FDA approval for choline, an ingredient in egg phosphatidylcholine, is expected to supplement growing importance as a dietary supplement. Increasing use of egg phosphatidylcholine as a solvent for insoluble pharmaceutical ingredients is expected to have a positive impact on the market for pharmaceutical applications.. Egg phosphatidylcholine is used in cosmetics as an emulsifier for creams. It prevents skin cell damage and improves elasticity of skin. Growing cosmetics industry owing to increasing income levels and changing lifestyle across globe is expected to drive the market growth over the forecast period. Moreover, medical benefits associated with egg ...
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A method for the rapid and quantitative separation of glycerophosphocholine, choline phosphate and choline upon ion-exchange columns is described. The method has been utilized to examine the stimulation of phosphatidylcholine breakdown in quiescent Swiss 3T3 cells in response to bombesin and 12-O-tetradecanoylphorbol 13-acetate (TPA). The stimulated generation of choline is shown to precede that of choline phosphate, with no effect upon glycerophosphocholine levels; but was attenuated in cells in which protein kinase C activity was down-regulated. The results thus suggest that stimulation of the cells with either bombesin or TPA activates phospholipase D-catalysed phosphatidylcholine breakdown by a common mechanism involving the activation of protein kinase C. ...
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https://www.evitamins.com/reviews/natures-plus-phosphatidyl-choline-108382
Phosphatidylcholine Complex Triple Pack ā€¢ Double Wood SupplementsPhosphatidylcholine Complex Triple Pack ā€¢ Double Wood Supplements
Phosphatidylcholine is a phospholipid with a choline molecule attached and is the main form of choline found in food. Double Woods Phosphatidylcholine contains 210 x 1200 mg softgels. Click here to learn more.
https://doublewoodsupplements.com/products/phosphatidylcholine-complex-triple-pack
PDF] Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol. | Semantic ScholarPDF] Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol. | Semantic Scholar
We use fluorescence microscopy to directly observe liquid phases in giant unilamellar vesicles. We find that a long list of ternary mixtures of high melting temperature (saturated) lipids, low melting temperature (usually unsaturated) lipids, and cholesterol produce liquid domains. For one model mixture in particular, DPPC/DOPC/Chol, we have mapped phase boundaries for the full ternary system. For this mixture we observe two coexisting liquid phases over a wide range of lipid composition and temperature, with one phase rich in the unsaturated lipid and the other rich in the saturated lipid and cholesterol. We find a simple relationship between chain melting temperature and miscibility transition temperature that holds for both phosphatidylcholine and sphingomyelin lipids. We experimentally cross miscibility boundaries both by changing temperature and by the depletion of cholesterol with beta-cyclodextrin. Liquid domains in vesicles exhibit interesting behavior: they collide and coalesce, can finger into
https://www.semanticscholar.org/paper/Separation-of-liquid-phases-in-giant-vesicles-of-of-Veatch-Keller/9a4ff9d67107a317f5bef96f7a683ea3374d881a
Global Egg Phosphatidylcholine Market 2016 Industry Trends, Sales, Supply, Demand, Analysis & Forecast to 2021 - Tech Report...Global Egg Phosphatidylcholine Market 2016 Industry Trends, Sales, Supply, Demand, Analysis & Forecast to 2021 - Tech Report...
The market research report by QY Research provides detailed study on the overall Egg Phosphatidylcholine market size, its financial positions, its unique selling points, key products, and key developments. This research report has segmented the Egg Phosphatidylcholine market based on the segments covering all the domains in terms of type, country, region, forecasting revenues, andā€¦
https://techreportinsights.wordpress.com/2017/02/14/global-egg-phosphatidylcholine-market-2016-industry-trends-sales-supply-demand-analysis-forecast-to-2021/
Investigations of lipid-protein interactions on monolayers of chain-substituted phosphatidylcholines. :: MPG.PuReInvestigations of lipid-protein interactions on monolayers of chain-substituted phosphatidylcholines. :: MPG.PuRe
Author: Dahmen-Levison, U. et al.; Genre: Journal Article; Published in Print: 2000; Title: Investigations of lipid-protein interactions on monolayers of chain-substituted phosphatidylcholines.
https://pure.mpg.de/pubman/faces/ViewItemFullPage.jsp?itemId=item_1930528
Source Naturals Phosphatidyl Choline In Lecithin 420 mg 180 Sgels - Swanson Health ProductsSource Naturals Phosphatidyl Choline In Lecithin 420 mg 180 Sgels - Swanson Health Products
Shop the best Source Naturals Phosphatidyl Choline In Lecithin 420 mg 180 Sgels products at Swanson Health Products. Trusted since 1969, we offer trusted quality and great value on Source Naturals Phosphatidyl Choline In Lecithin 420 mg 180 Sgels products.
https://www.swansonvitamins.com/source-naturals-phosphatidyl-choline-in-lecithin-420-mg-180-sgels
On the role of phospholipids in reconstituted cytochrome P-450 system. A model study using dilauroyl and distearoyl...
TY - JOUR. T1 - On the role of phospholipids in reconstituted cytochrome P-450 system. A model study using dilauroyl and distearoyl glycerophosphocholine.. AU - Rietjens, I.M.C.M.. AU - Ancher, L.J.. AU - Veeger, C.. PY - 1989. Y1 - 1989. M3 - Article. VL - 181. SP - 309. EP - 316. JO - European Journal of Biochemistry. JF - European Journal of Biochemistry. SN - 0014-2956. ER - ...
https://research.wur.nl/en/publications/on-the-role-of-phospholipids-in-reconstituted-cytochrome-p-450-sy
Deconfinement and Quantum Liquid Crystalline States of Dipolar Fermions in Optical Lattices - Kent Academic RepositoryDeconfinement and Quantum Liquid Crystalline States of Dipolar Fermions in Optical Lattices - Kent Academic Repository
We describe a simple model of fermions in quasi-one dimension that features interaction-induced deconfinement (a phase transition where the effective dimensionality of the system increases as interactions are turned on) and which can be realised using dipolar fermions in an optical lattice(1). The model provides a relisation of a soft quantum matter phase diagram of strongly-correlated fermions, featuring meta-nematic, smectic and crystalline states, in addition to the normal Fermi liquid. In this paper we review the model and discuss in detail the mechanism behind each of these transitions on the basis of bosonization and detailed analysis of the RPA susceptibility. ...
https://kar.kent.ac.uk/25606/
1,2-dioleoyl-sn-glycero-3-phosphocholine 4235-95-4 H-NMR | C-NMR Spectral Analysis NMR Spectrum1,2-dioleoyl-sn-glycero-3-phosphocholine 4235-95-4 H-NMR | C-NMR Spectral Analysis NMR Spectrum
1,2-dioleoyl-sn-glycero-3-phosphocholine 4235-95-4 NMR spectrum, 1,2-dioleoyl-sn-glycero-3-phosphocholine H-NMR spectral analysis, 1,2-dioleoyl-sn-glycero-3-phosphocholine C-NMR spectral analysis ect.
http://www.molbase.com/en/hnmr_4235-95-4-moldata-45766.html
Discount China Wholesale Phosphatidylcholine 70%, 1KG/BAG [216]- US$500.00 - Allcosmeticsource.comDiscount China Wholesale Phosphatidylcholine 70%, 1KG/BAG [216]- US$500.00 - Allcosmeticsource.com
Allcosmeticsource.com Phosphatidylcholine 70%, 1KG/BAG [216]- INTRODUCTION What is Phosphatidylcholine? Phosphatidylcholine is an integral component of every cell in the human body. Consumed regularly as part of our normal diets, Phosphatidylcholine has also been proven safe and effective over decades of study as a therapeutic agent. Researched extensively by scientists, Phosphatidylcholine has been shown to play a vital role
http://allcosmeticsource.com/phosphatidylcholine-70-1kgbag-p-216.html
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine/1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1-rac-glycerol) sodium salt lipid...1,2-dioleoyl-sn-glycero-3-phosphoethanolamine/1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1-rac-glycerol) sodium salt lipid...
Page contains details about 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine/1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1-rac-glycerol) sodium salt lipid bilayer . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
http://nano.nature.com/nano/GR-M7923231
Choline - Bluebonnet - Phosphatidyl Choline 420mg 60sg
Triple strength lecithin, concentrated source of phosphatidyl choline. Available in easy-to-swallow softgels for maximum assimilation and absorption.
http://www.totaldiscountvitamins.com/product/729/choline
Phosphatidyl Choline by Allergy ResearchPhosphatidyl Choline by Allergy Research
Phosphatidyl choline, a primary component of lecithin, is converted in the brain into the neurotransmitter acetylcholine. Researchers have found acetylcholine to be a primary carrier of memory.
https://healthremedies.com/shop/allergy-research-group/phosphatidyl-choline-allergy-research/
Bluebonnet - Phosphatidyl Choline 420mg 60sg
Triple strength lecithin, concentrated source of phosphatidyl choline. Available in easy-to-swallow softgels for maximum assimilation and absorption.
https://www.totaldiscountvitamins.com/create_review/729/choline
phosphatidylcholine(1+) 8002-43-5 Route Of Synthesis Synthetic Routesphosphatidylcholine(1+) 8002-43-5 Route Of Synthesis Synthetic Routes
phosphatidylcholine(1+) 8002-43-5 route of synthesis, phosphatidylcholine(1+) chemical synthesis methods, phosphatidylcholine(1+) synthetic routes ect.
http://www.molbase.com/en/synthesis_8002-43-5-moldata-4410.html
1,2-Didecanoyl-sn-glycero-3-phosphocholine ā‰„99% (TLC) | 3436-44-01,2-Didecanoyl-sn-glycero-3-phosphocholine ā‰„99% (TLC) | 3436-44-0
1,2-Didecanoyl-sn-glycero-3-phosphocholine ā‰„99% (TLC); CAS Number: 3436-44-0; Synonyms: Didecanoyllecithin,3-sn-Phosphatidylcholine, 1,2-didecanoyl,PC,PC(10:0/10:0),(7R)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-(1-oxodecyl)oxy-3,5,9-trioxa-4-phosphanonadecan-1-aminium 4-oxide, inner salt,1,2-Dicaprinoyl-sn-glycero-3-phosphocholine,L-Ī±-Phosphatidylcholine, didecanoyl; find Sigma-Aldrich-P7081 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich
https://www.sigmaaldrich.com/US/en/product/sigma/p7081
Species profile search | Environment, land and water | Queensland GovernmentSpecies profile search | Environment, land and water | Queensland Government
Search or browse for species information such as species names, notes and images for Queenslands native and naturalised plants and animals from the WildNet database.
https://apps.des.qld.gov.au/species-search/?kingdom=plants&class=equisetopsida&family=restionaceae
Species profile search | Environment, land and water | Queensland GovernmentSpecies profile search | Environment, land and water | Queensland Government
Search or browse for species information such as species names, notes and images for Queenslands native and naturalised plants and animals from the WildNet database.
https://apps.des.qld.gov.au/species-search/?kingdom=animals&class=aves&family=orthonychidae
All About Endangered Species - Species Profiles | SeaWorld Parks & EntertainmentAll About Endangered Species - Species Profiles | SeaWorld Parks & Entertainment
Take a deep dive and learn all about endangered species - from Federal wildlife laws to conservation organizations. Click here for a library of endangered species resources.
https://seaworld.org/animals/all-about/endangered-species/species-profiles/
Life Extension Micellized Pure Pc, 120ml - Apran
The naturally occurring substance phosphatidyl choline is a primary building block in the body. Its one of several so called phospholipids that are structural elements of all cell membranes, facilitating membrane integrity and healthy cell function.. Phosphatidyl choline is also a normal constituent of bile and promotes fat emulsification, absorption, and transport. Its metabolism provides choline to the body which is needed by the brain to produce acetylcholine, a major neurotransmitter that transmits signals between nerve cells.. Sufficient levels of phosphatidyl choline have been shown to support many biochemical pathways and enhance physiology.. ...
http://www.apran.com/en/life-extension-micellized-pure-pc-120ml.html
Phosphatidylcholine(PC),orison chemicals limitedPhosphatidylcholine(PC),orison chemicals limited
the basic information about Phosphatidylcholine(PC) produced in China and supplied by Orison chemicals Limited, high quality and bulk quantity of Phosphatidylcholine(PC) from soy
http://orisonchem.com/market-info-data/phosphatidylcholine_LeciPROPC_info.html
Buy Phosphatidylcholine: How to Decide if this is the Best Supplement for youBuy Phosphatidylcholine: How to Decide if this is the Best Supplement for you
Where to Buy Phosphatidylcholine supplements and powder. Reviews of the Best Phosphatidylcholine capsules, liquids, or injctions and the lowest prices.
https://nootriment.com/buy-phosphatidylcholine/
Name Changes in MassoniaName Changes in Massonia
I find it interesting that Nhu points out the name was something established by Baker over 100 years ago, but traditional taxonomists that started taking in a more inclusive approach lumped the two as nodes of variation, yet now molecular work has shown they are different molecular species. Now what constitutes that? I think the percent of divergence (usually from a small sampling of both specimens and molecular markers) varies between phyla, families, genera, and maybe even subspecies. For fungi, it is typically about 3 percent, but within plants can vary a lot. Nonetheless, if molecular work does not show two nodes as monophyletic, but the morphology allows for separation, one can still call them separate species! Maybe the unpublished molecular work shows them in two distinct clades that diverged some time ago, or are these two Massonia not even part of the same clade? If they were two clades that diverged recently, but have a small amount of sequence divergence might they still be considered ...
http://www.pacificbulbsociety.org/pbslist/2013-January/ij21mmq2k6jgikvcivc46hs5q3.html
Phosphatidylcholine Supplements - Tagged Does Not Contain: Wheat - Seeking HealthPhosphatidylcholine Supplements - Tagged Does Not Contain: Wheat - Seeking Health
Phosphatidylcholine is produced naturally by our bodies and is important for the health of our cell membranes, liver, heart, muscles and brain. In order to p...
https://www.seekinghealth.com/collections/phosphatidylcholine-supplements?constraint=does-not-contain_wheat&view=view-36&grid_list
BURN inches of FAT with Lipostabil (phosphatidylcholine) for only $5.50 per amp?! | superhumangearBURN inches of FAT with Lipostabil (phosphatidylcholine) for only $5.50 per amp?! | superhumangear
|Yes, that is true. We have 5% and 10% phosphatidylcholine with deoxycholate! $5.50 /5% 5 ml, $7.50 /10% 5 [email protected] are lipo-dissolve injections? Lipo-dissolve injections have become an increasingly popular means to remove excess fat. The procedure goes by many names (e.g., LipostabilĀ®, Lipodissolve, Flab-Jab, Lipojection, Lipotherapy, etc.) and involves the injection of mixtures ofā€¦
https://superhumangear.wordpress.com/2010/06/07/burn-inches-of-fat-with-lipostabil-phosphatidylcholine-for-only-5-50-per-amp/
Plants Profile for ShibataeaPlants Profile for Shibataea
The Plants Database includes the following 1 species of Shibataea . Click below on a thumbnail map or name for species profiles ...
https://www.plants.usda.gov/core/profile?symbol=SHIBA
Plants Profile for Blepharidachne (desertgrass)Plants Profile for Blepharidachne (desertgrass)
The Plants Database includes the following 2 species of Blepharidachne . Click below on a thumbnail map or name for species profiles ...
https://www.plants.usda.gov/core/profile?symbol=BLEPH
Plants Profile for Harbouria (harbouria)Plants Profile for Harbouria (harbouria)
The Plants Database includes the following 1 species of Harbouria . Click below on a thumbnail map or name for species profiles ...
https://plants.usda.gov/core/profile?symbol=HARBO
Plants Profile for Thelesperma (greenthread)Plants Profile for Thelesperma (greenthread)
The Plants Database includes the following 12 species of Thelesperma . Click below on a thumbnail map or name for species profiles ...
https://plants.usda.gov/core/profile?symbol=THELE
Correlation between plasma and hepatic phosphatidylcholine hydroperoxide, energy charge, and total glutathione content in...
TY - JOUR. T1 - Correlation between plasma and hepatic phosphatidylcholine hydroperoxide, energy charge, and total glutathione content in ischemia reperfusion injury of rat liver. AU - Suzuki, M.. AU - Fukuhara, K.. AU - Unno, Michiaki. AU - Htwe, T.. AU - Takeuchi, H.. AU - Kakita, T.. AU - Matsuno, S.. PY - 2000/1/1. Y1 - 2000/1/1. N2 - Background/Aims: Oxygen-derived free radicals are believed to be responsible for the hepatocellular injury leading to liver failure following ischemia-reperfusion in liver, endotoxemia and many other life-threatening illnesses. This study was designed to investigate the reactive oxygen species interaction in lipid peroxidation, the adenosine and energy charge levels of liver cells, and total glutathione content in ischemic-reperfusion injury of liver in rat. Methodology: To prevent intestinal congestion during the clamping of vascular structures, subcutaneous transposition of the spleen was done beforehand. Four to six weeks later, after the development of ...
https://tohoku.pure.elsevier.com/en/publications/correlation-between-plasma-and-hepatic-phosphatidylcholine-hydrop/
Phosphatidylcholines: Beyond the MembranePhosphatidylcholines: Beyond the Membrane
Phosphatidylcholines (PC) are the most abundant phospholipids in mammalian cells, where they serve well-characterized structural roles, maintaining membrane integrity, facilitating lipoprotein assembly and serving as a surfactant in the lung. Over the past decade, seminal papers have been published that describe novel roles for specific PC species derived from both the cytidine diphosphate-choline (CDP-choline) and phosphatidylethanolamine N-methyltransferase (PEMT) pathways of PC synthesis; these roles include both nuclear receptor agonism and generating critical physiological pools of the omega 3 fatty acid, docosahexaenoic acid (DHA). In addition to these novel functions, complex interactions between PC and its substrate, choline, with growth and energetic status have emerged, following the observation that the mammalian target of rapamycin complex 1 (mTORC1) is a major regulator of PC synthesis through the CDP-choline pathway. Presented in this dissertation are the tests of our primary ...
https://ecommons.cornell.edu/handle/1813/59560
Thrombin induces proliferation of osteoblast-like cells through phosphatidylcholine hydrolysis<...Thrombin induces proliferation of osteoblast-like cells through phosphatidylcholine hydrolysis<...
TY - JOUR. T1 - Thrombin induces proliferation of osteoblast-like cells through phosphatidylcholine hydrolysis. AU - Suzuki, Atsushi. AU - Kozawa, Osamu. AU - Shinoda, Junji. AU - Watanabe, Yasuko. AU - Saito, Hidehiko. AU - Oiso, Yutaka. PY - 1996/7/1. Y1 - 1996/7/1. N2 - We examined the effect of thrombin on phosphatidylcholine-hydrolyzing phospholipase D activity in osteoblast-like MC3T3-E1 cells. Thrombin stimulated the formation of choline dose dependently in the range between 0.01 and 1 U/ml, but not the phosphocholine formation. Diisopropylfluorophosphate (DFP)-inactivated thrombin had little effect on the choline formation. The combined effects of thrombin and 12-O-tetradecanoylphorbol-13-acetate, a protein kinase C-activating phorbol ester, on the choline formation were additive. Staurosporine, an inhibitor of protein kinases, had little effect on the thrombin-induced formation of choline. Combined addition of thrombin and NaF, an activator of heterotrimeric GTP-binding protein, did not ...
https://pure.fujita-hu.ac.jp/en/publications/thrombin-induces-proliferation-of-osteoblast-like-cells-through-p
Pathogens | Free Full-Text | Interaction of Phenol-Soluble Modulins with Phosphatidylcholine VesiclesPathogens | Free Full-Text | Interaction of Phenol-Soluble Modulins with Phosphatidylcholine Vesicles
Several members of the staphylococcal phenol-soluble modulin (PSM) peptide family exhibit pronounced capacities to lyse eukaryotic cells, such as neutrophils, monocytes, and erythrocytes. This is commonly assumed to be due to the amphipathic, Ī±-helical structure of PSMs, giving PSMs detergent-like characteristics and allowing for a relatively non-specific destruction of biological membranes. However, the capacities of PSMs to lyse synthetic phospholipid vesicles have not been investigated. Here, we analyzed lysis of synthetic phosphatidylcholine (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, POPC) vesicles by all Staphylococcus aureus and S. epidermidis PSMs. In addition, we investigated the lytic capacities of culture filtrates obtained from different S. aureus PSM deletion mutants toward POPC vesicles. Our results show that all staphylococcal PSMs have phospholipid vesicle-lysing activity and the capacity of S. aureus culture filtrate to lyse POPC vesicles is exclusively dependent on PSMs.
http://mdpi.com/2076-0817/1/1/3/xml
Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine by endothelin, a complete...Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine by endothelin, a complete...
The mitogenic activity of endothelin and its ability to stimulate PtdIns(4,5)P2 and phosphatidylcholine turnover in Rat-1 fibroblasts was studied. Stimulated incorporation of [3H]thymidine occurred in the absence of any other added growth factors. The endothelins stimulated rapid generation of both Ins(1,4,5)P3 and choline. Endothelin-1 and endothelin-2 were equipotent in stimulating both responses, but endothelin-3 was less potent. Endothelin-1-stimulated Ins(1,4,5)P3 generation reached a maximum at 5 s and then declined; however, the response was long-lived, with a 4.5-fold elevation over basal still observed after 15 min. Endothelin-stimulated choline generation was observed with no increase in choline phosphate; indeed, the apparent level of this metabolite fell after 30 min of stimulation, presumably due to the observed stimulation of phosphatidylcholine synthesis. The endothelin-stimulated increase in choline generation was abolished in cells where protein kinase C was down-regulated. ...
http://www.biochemj.org/content/272/3/761
DNA-Induced Aggregation and Fusion of Phosphatidylcholine Liposomes in the Presence of Multivalent Cations Observed by the Cryo...DNA-Induced Aggregation and Fusion of Phosphatidylcholine Liposomes in the Presence of Multivalent Cations Observed by the Cryo...
Read DNA-Induced Aggregation and Fusion of Phosphatidylcholine Liposomes in the Presence of Multivalent Cations Observed by the Cryo-TEM Technique, The Journal of Membrane Biology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.deepdyve.com/lp/springer_journal/dna-induced-aggregation-and-fusion-of-phosphatidylcholine-liposomes-in-g0JX5gp8ng
Phosphatidylcholine (PC) | Reference Library - Supplements | Supplements | Healthways, Inc.
What Is It? A member of the phospholipid or fatty acid class of compounds, phosphatidylcholine (PC) is the major component of lecithin, a compound that naturally occurs in all cell membranes and is essential for biological functions. (1, 2) Lecithin is found in eggs and plants such as mustard, soy, and sunflower. Although egg lecithin contains a large amount of phosphatidylcholine (69%), plant lecithins are considered safer than animal sources. As a result, most PC supplements are derived from soy lecithin which contains 24% phosphatidylcholine. Lecithin-derived phosphatidylcholine acts as a surfactant, which means that it is responsible for maintaining the surface tension of cell membranes and controls what enters and leaves the cell through the membranes.. In the body, phosphatidylcholine is the major supplier of choline, which is a precursor to the neurotransmitter acetylcholine. Acetylcholine is necessary for optimal brain and nerve function. As a result, researchers are interested in using ...
http://wholehealthmd.com/main/supplements/phosphatidylcholine-pc-99.aspx
The effect of saturated phospholipids on human skin - Phospholipid Research CenterThe effect of saturated phospholipids on human skin - Phospholipid Research Center
How deep can drugs penetrate into your skin?. We presented our new skin penetration study with saturated phospholipids at the 11th PBP world meeting, on 22 March, 2018 in Granada.. The Phospholipid Research Center and Lipoid GmbH tracked topically applied phospholipids among other skin lipids - with the help of Lipotype lipidomics.. Many dermatological products contain phospholipids whose properties change with their saturation. Saturated lipids are gel-like at body temperature, while unsaturated lipids are more liquid. This influences drug delivery and interactions with skin.. Download poster (PDF) ...
https://www.phospholipid-institute.com/2018/03/22/the-effect-of-saturated-phospholipids-on-human-skin/
Source Naturals, Phosphatidyl Choline, in Lecithin, 420 mg - 180 SoftgelsSource Naturals, Phosphatidyl Choline, in Lecithin, 420 mg - 180 Softgels
|ul| |li|Dietary Supplement|/li| |/ul| |p|Source Naturals Phosphatidyl Choline provides premium quality and potency. This product has been concentrated to contain 3 times the phosphatidyl choline found in ordinary lecithin. This special soy lecithin al
http://www.pickvitamin.com/source-naturals-phosphatidyl-choline-in-lecithin-420-mg-180-softgels.html
Pharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjectsPharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjects
IdB 1016 is a complex of silybin (the main active component of silymarin) and phosphatidylcholine, which in animal models shows greater oral bioavailability and therefore greater pharmacological activity compared with pure silybin and silymarin. In order to assess its pharmacokinetic profile in man, ā€¦
https://pubmed.ncbi.nlm.nih.gov/2088770/?dopt=Abstract
Plus it
The FA composition of skeletal muscle phospholipids is altered in both humans (2, 3, 27) and rats (24, 32, 44) after chronic (ā‰„4 wk) exercise training. Here we provide novel data describing the effect of exercise training on skeletal muscle phospholipid molecular species profile using ESI-MS. This investigation characterized relative changes in the phospholipid profile of both oxidative (RVL) and glycolytic (WVL) muscle fibers with low and high-intensity exercise training. We have also characterized, for the first time, differences in the profile of phospholipid molecular species between these two muscle fiber types.. Previous studies have reported that long-chain n-3 PUFAs are higher in the insulin-sensitive type I and type IIa fibers (32) and that type I fibers have a preference for stearic acid (18:0) over palmitic acid (16:0) (7, 17). The results of the present study reveal that these differences are also manifest in whole phospholipid PA and PE species (Table 3). Even though the ...
http://jap.physiology.org/content/97/5/1823
Effect of aerosolized dipalmitoyl lecithin on oxygen-toxic rat lungs.
Pulmonary surfactant is reduced in oxygen toxicity but whether this represents a decrease in production or inactivation of surface-active material already present is not known. We divided 200 g male Wister-Lewis rats into different experimental group
http://www.biomedsearch.com/nih/Effect-aerosolized-dipalmitoyl-lecithin-oxygen/1173344.html
Phosphatidylcholine Market (2014 - 2019) | Phosphatidylcholine Market Report Trends, Analysis, Forecast - Micro Market MonitorPhosphatidylcholine Market (2014 - 2019) | Phosphatidylcholine Market Report Trends, Analysis, Forecast - Micro Market Monitor
Phosphatidylcholine market research report covering industry trends, market share, market growth analysis and projection by MIcroMarketMonitor.com. Phosphatidylcholine market report includes,|Key question answered| What are market estimates and forecasts; which of Phosphatidylcholine markets are doing well and which are not? and |Audience for this report| Phosphatidylcholine companies.
http://www.micromarketmonitor.com/market-report/phosphatidylcholine-reports-5345348522.html
View all posts in Buy Non-GMO Lecithin Powder
About Non-GMO Lecithin Powder Lecithin is a complex fatty substance found in all animal and plant tissues which is composed of phosphoric acid, sterols, carbohydrates, fatty acids, glycerol, glycolipids, sphingolipids, phospholipids (e.g., phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol, and phosphatidyl serine), and various other compounds. Lecithin is naturally found in foods, especially fatty foods such as egg yolk, soybeans, nuts, wheat germ, fish, legumes, and peanuts. It is also present, to a lesser extent, in foods like yeast, grains, bee pollen, cauliflower, and cabbage. A key component of lecithin, phosphatidyl choline, is the main lipid component in both plant and [ā€¦]. ...
http://blogs.natureshappiness.com/tag/buy-non-gmo-lecithin-powder/
UNIGE - Matile Group - PublicationsUNIGE - Matile Group - Publications
We report the design, synthesis, and evaluation of rigid oligonaphthalenediimide (O-NDI) rods that are expected to act as transmembrane anionāˆ’Ļ€ slides. Studies in fluorogenic large unilamellar egg yolk phosphatidylcholine vesicles reveal that rigid O-NDI rods mediate anion-selective transport with a rare halide VI selectivity sequence (Cl- , F- , Br- , I-). This and decreasing activity, selectivity, and halide sequence with increasing positive charge of the rod termini support the occurrence of anionāˆ’Ļ€ interactions. A strong anomalous mole fraction effect in Cl-/I- mixtures is in agreement with the existence of multiple active sites along the anionāˆ’Ļ€ slide and multi-anion hopping as a mechanism of transport. The strong inverted NDI quadruple moment found by DFT calculations is in excellent agreement with these results.. [open archive unige:6919 ā€¢ pdf ...
https://www.unige.ch/sciences/chiorg/matile/publications?pubId=653&pubNum=108
Phosphatidylcholine | Article about phosphatidylcholine by The Free DictionaryPhosphatidylcholine | Article about phosphatidylcholine by The Free Dictionary
Looking for phosphatidylcholine? Find out information about phosphatidylcholine. Biochem any of a group of phospholipids that are found in many plant and animal tissues, esp egg yolk: used in making candles, cosmetics, and inks, and as... Explanation of phosphatidylcholine
https://encyclopedia2.thefreedictionary.com/phosphatidylcholine
Photosensitive liposomes for DMPC phospholipid application-AVT (Shanghai) Pharmaceutical Tech Co., LtdPhotosensitive liposomes for DMPC phospholipid application-AVT (Shanghai) Pharmaceutical Tech Co., Ltd
Speaking of DMPC phospholipids, you should not be unfamiliar with the product name dimyristoyl lecithin. This synthetic phospholipid with a PC content of 99 has many applications. One of them is photo...
http://en.avt-avt.com/article-item-2962.html
Specific Phospholipid Oxidation Products Inhibit Ligand Activation of Toll-Like Receptors 4 and 2 | Arteriosclerosis,...Specific Phospholipid Oxidation Products Inhibit Ligand Activation of Toll-Like Receptors 4 and 2 | Arteriosclerosis,...
The current studies demonstrate that in both ECs and macrophages, ox-PAPC inhibits the ability of bacterial lipids that target TLR4 and TLR2 to increase synthesis of chemokines. Furthermore, we identify KOdiA-PC and POVPC as the major, specific phospholipids in ox-PAPC responsible for this inhibition.. Our studies addressed the mechanism of this inhibition and concluded that the inhibition of LPS action by ox-PAPC in these cell types was mediated by effects at the cellular level. This conclusion was based on the observation that pretreatment of cells with ox-PAPC followed by exposure to LPS was as effective as cotreatment to inhibit LPS action (Figure 3). To determine the cellular target of ox-PAPC inhibition, we first examined the effect of ox-PAPC on intracellular signaling from MyD88 to NF-ĪŗB activation. Our results indicate that ox-PAPC does not inhibit the pathway from MyD88 to NF-ĪŗB activation (Figures 2B and 2C), because no effect on IL-1Ī² action, which shares this pathway, was ...
http://atvb.ahajournals.org/content/23/7/1197
Closely related oxidized phospholipids differentially modulate the physicochemical properties of lipid particles - UQ eSpace
Oxidation of glycerophospholipids results in the formation of large variety of oxidized phospholipid products that differs significantly in their chemical compositions and molecular structures. Biological activities of these oxidized products also differ considerably. Here we report the comparisons of the physicochemical properties of non-oxidized phospholipid particle containing two closely related tOx-PLs: 1-palmitoyl-2-(5-keto-6-octendioyl)-sn-glycero-3-phosphocholine (KOdiA-PC) and 1-palmitoyl-2-(9-keto-10-dodecendioyl)-sn-glycero-3-phosphocholine (KDdiA-PC). DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) was used as a model membrane non-oxidized phospholipid. Physicochemical properties of the lipid particles were characterized by using fluorescence spectroscopy, native polyacrylamide gel and agarose gel electrophoresis. Our result shows that the presence of closely related tOx-PLs, which differ only in the chemical composition of the oxidized fatty acyl chains at the sn-2 position, ...
https://espace.library.uq.edu.au/view/UQ:472306
Phospholipid Resource | Learn About, Share and Discuss Phospholipid At Popflock.comPhospholipid Resource | Learn About, Share and Discuss Phospholipid At Popflock.com
Get Phospholipid essential facts. View Videos or join the Phospholipid discussion. Add Phospholipid to your PopFlock.com topic list or share. Phospholipid at popflock.com
https://popflock.com/learn?s=Phospholipid
Origin of a superlattice observed in Li0.9Mo6O17 by scanning tunneling microscopy - RHK TechnologyOrigin of a superlattice observed in Li0.9Mo6O17 by scanning tunneling microscopy - RHK Technology
Figure 1: Zoomed 5 nm image. Using Fourier filtering of the larger raw image, the superlattice is removed, and only the crystal lattice remains. Specifically, in filtering, we selected all of the crystallographic Bragg peaks connected by reciprocal lattice vectors appearing in the FFT. (PHYSICAL REVIEW B 93, 045430 (2016)). We use scanning tunneling microscopy to study the lithium molybdenum purple bronze (Li0.9Mo6O17) at room temperature. Our measurements allow us to identify the single-crystal cleave plane and show that it is possible to obtain clean cleaved surfaces reflecting the crystal structure without the complications of nanoscale surface disorder. In addition to the crystal lattice, we observe a coexisting discommensurate superlattice with wave vectors q = 0.5aāˆ— Ā± 0.25bāˆ—. We propose that the origin of the superstructure is a surface reconstruction that is driven by cleaving along a crystal plane that contains in-plane MoO4 tetrahedra connected to out-of-plane MoO6 octahedra ...
https://www.rhk-tech.com/origin-superlattice-observed-li0-9mo6o17-scanning-tunneling-microscopy
Brevet US5962069 - Process for fabricating layered superlattice materials and AB03 type metal ... - Google BrevetsBrevet US5962069 - Process for fabricating layered superlattice materials and AB03 type metal ... - Google Brevets
A liquid precursor containing a metal is applied to a first electrode, dried in air at a first temperature of 160 C. and then a second temperature of 260 C., RTP baked at a temperature of 300 C. in oxygen, RTP baked at a temperature of 650 C. in nitrogen, and annealed at a temperature of 800 C. in nitrogen to form a strontium bismuth tantalate layered superlattice material. A second electrode is deposited and then the device is patterned to form a capacitor, and a second anneal is performed at a temperature of 800 C. in nitrogen. Alternatively, the second anneal may be performed in oxygen at a temperature of 600 C. or less. In this manner, a high electronic quality thin film of a layered superlattice material is fabricated without a high-temperature oxygen anneal.
http://www.google.fr/patents/US5962069
Lecithin - Learn About Lecithin - Buy Lecithin Supplements - Nutrition ExpressLecithin - Learn About Lecithin - Buy Lecithin Supplements - Nutrition Express
Low prices on Lecithin! Cost-effective source of choline and inositol. Lecithin is one of natures miracle foods. An ingredient in lecithin, choline, is used by your body to produce acetylcholine, which allows nerve cells to send impulses properly. Lecithin also supports a healthy heart mainly due to lecithin being abundant in inositol.
https://www.nutritionexpress.com/supplements/lecithin/lindberg+lecithin+1200+mg+120+softgels.aspx
Lecithin - Learn About Lecithin - Buy Lecithin Supplements - Nutrition ExpressLecithin - Learn About Lecithin - Buy Lecithin Supplements - Nutrition Express
Low prices on Lecithin! Cost-effective source of choline and inositol. Lecithin is one of natures miracle foods. An ingredient in lecithin, choline, is used by your body to produce acetylcholine, which allows nerve cells to send impulses properly. Lecithin also supports a healthy heart mainly due to lecithin being abundant in inositol.
https://www.nutritionexpress.com/health+concerns/brain+memory/lecithin/lewis+labs+lecithin+16+ounces.aspx
Schniarfer - Valerian & Laureline graphic novels - Species profile - Writeups.orgSchniarfer - Valerian & Laureline graphic novels - Species profile - Writeups.org
Everything you did not actually want to know about Schniarfers, as they appear in Valerian & Laureline graphic novels. Pictures, physiology, schniarf...
https://www.writeups.org/schniarfer-valerian-laureline-schniarfeur/
Sunflower Liquid Lecithin | NOW FoodsSunflower Liquid Lecithin | NOW Foods
Naturally Occurring Phosphatidyl Choline & Other Phosphatides Soy-Free, Non-GMO NOWĀ® Sunflower Liquid Lecithin has Phosphatidyl Choline, the most abundant phosp
https://www.nowfoods.com/supplements/sunflower-liquid-lecithin
Watching the heart beat of moleculesWatching the heart beat of molecules
Scientists report on a new method of rapidly identifying different molecular species under a microscope. Their technique of coherent Raman spectro-imaging with two laser frequency combs takes a big step towards the holy grail of real-time label-free biomolecular imaging.
https://www.nanowerk.com/news2/newsid=32775.php
Vol 9: Observation of linear and quadratic magnetic field-dependence of magneto-photocurrents in InAs-GaSb superlattice. - pdf...
Vol 9: Observation of linear and quadratic magnetic field-dependence of magneto-photocurrents in InAs-GaSb superlattice.. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentaciĆ³n y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
http://libros.duhnnae.com/2017/jun2/149655622817-Vol-9-Observation-of-linear-and-quadratic-magnetic-field-dependence-of-magneto-photocurrents-in-InAs-GaSb-superlattice-Li-Yuan-Liu-Yu-Jiang-C.php
Asymmetric distribution of phosphatidylcholine and sphingomyelin between micellar and vesicular phases: Potential implications...
Fingerprint Dive into the research topics of Asymmetric distribution of phosphatidylcholine and sphingomyelin between micellar and vesicular phases: Potential implications for canalicular bile formation. Together they form a unique fingerprint. ...
https://utsouthwestern.pure.elsevier.com/en/publications/asymmetric-distribution-of-phosphatidylcholine-and-sphingomyelin-/fingerprints/
Workshop: Colin Mclean and Jim Bednar - ANC | Institute for Adaptive and Neural Computation
Colin Mclean. Using Probabilistic Clustering to help Identify Multiple Protein Instances in Static PPI Datasets. Functioning of synapses is governed by macromolecular complexes held together by protein-protein, protein-lipid and lipid-lipid interactions. In the Post-Synaptic Density (PSD) multi-protein complexes contain multiple core proteins, such as the scaffolding proteins: PSD-95, SHANK, SAPAP. Commonly used clustering techniques fail to capture the role of these important proteins, by placing each protein in only a single community. Probabilistic clustering techniques circumnavigate this problem by assigning a probability to each protein belonging to a community, allowing overlapping structure of the data. We have implemented a principled statistical approach, based on clustering edges between nodes, for finding overlapping communities in our static Protein-Protein Interaction (PPI) networks ...
http://www.anc.ed.ac.uk/events/workshop-colin-mclean-and-jim-bednar-chair-maria-shippi
Publikationen | Max-Planck-Institut fĆ¼r biophysikalische ChemiePublikationen | Max-Planck-Institut fĆ¼r biophysikalische Chemie
Pinheiro, T. J. T.; Vaz, W.L.C.; Geraldes, C. F. G. C.; Prado, A.; Dacosta, M. S.: A 31P-NMR study on multilamellar liposomes formed from the lipids of a thermophilic bacterium. Biochemical and Biophysical Research Communications 148 (1), S. 397 - 402 (1987 ...
https://www.mpibpc.mpg.de/publication-search/72093?person=%2Fpersons%2Fresource%2Fpersons15949
PhosphatidylcholinePhosphatidylcholine
... which contains both phosphatidylcholine and deoxycholate (Figure 3). This bile salt is used to solubilize phosphatidylcholine ... Dipalmitoyl phosphatidylcholine (a.k.a. lecithin) is a major component of pulmonary surfactant and is often used in the L/S ... Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup. They are a major component of ... While phosphatidylcholines are found in all plant and animal cells, they are absent in the membranes of most bacteria, ...
https://en.wikipedia.org/wiki/Phosphatidylcholine
Phosphatidylcholine synthasePhosphatidylcholine synthase
In enzymology, a phosphatidylcholine synthase (EC 2.7.8.24) is an enzyme that catalyzes the chemical reaction CDP- ... whereas its two products are CMP and phosphatidylcholine. This enzyme belongs to the family of transferases, specifically those ... "Cloning and characterization of the gene for phosphatidylcholine synthase". J. Biol. Chem. 275 (25): 18919-25. doi:10.1074/jbc. ... "Plant-exuded choline is used for rhizobial membrane lipid biosynthesis by phosphatidylcholine synthase". J. Biol. Chem. 274 (28 ...
https://en.wikipedia.org/wiki/Phosphatidylcholine_synthase
Phosphatidylcholine desaturasePhosphatidylcholine desaturase
In enzymology, a phosphatidylcholine desaturase (EC 1.14.19.22, previously EC 1.3.1.35) is an enzyme that catalyzes the ... Slack CR, Roughan PG, Browse J (June 1979). "Evidence for an oleoyl phosphatidylcholine desaturase in microsomal preparations ... Stymne S, Appelqvist LA (October 1978). "The biosynthesis of linoleate from oleoyl-CoA via oleoyl-phosphatidylcholine in ...
https://en.wikipedia.org/wiki/Phosphatidylcholine_desaturase
Phosphatidylcholine 12-monooxygenasePhosphatidylcholine 12-monooxygenase
In enzymology, a phosphatidylcholine 12-monooxygenase (EC 1.14.13.26) is an enzyme that catalyzes the chemical reaction 1-acyl- ...
https://en.wikipedia.org/wiki/Phosphatidylcholine_12-monooxygenase
Phosphatidylcholine transfer proteinPhosphatidylcholine transfer protein
In humans, phosphatidylcholine transfer protein is encoded by the PCTP gene. PCTP transfers phosphatidylcholine molecules ... "Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into ... Phosphatidylcholine transfer protein (PCTP) also known as StAR-related lipid transfer domain protein 2 (STARD2) is a specific ... "Entrez Gene: phosphatidylcholine transfer protein". van Helvoort A, de Brouwer A, Ottenhoff R, Brouwers JF, Wijnholds J, ...
https://en.wikipedia.org/wiki/Phosphatidylcholine_transfer_protein
Phosphatidylcholine-dolichol O-acyltransferasePhosphatidylcholine-dolichol O-acyltransferase
In enzymology, a phosphatidylcholine---dolichol O-acyltransferase (EC 2.3.1.83) is an enzyme that catalyzes the chemical ... The systematic name of this enzyme class is 3-sn-phosphatidylcholine:dolichol O-acyltransferase. Keenan RW, Kruczek ME (1976 ... the two substrates of this enzyme are 3-sn-phosphatidylcholine and dolichol, whereas its two products are 1-acyl-sn-glycero-3- ... reaction 3-sn-phosphatidylcholine + dolichol ā‡Œ {\displaystyle \rightleftharpoons } 1-acyl-sn-glycero-3-phosphocholine + ...
https://en.wikipedia.org/wiki/Phosphatidylcholineā€”dolichol_O-acyltransferase
Phosphatidylcholine-retinol O-acyltransferasePhosphatidylcholine-retinol O-acyltransferase
In enzymology, a phosphatidylcholine---retinol O-acyltransferase (EC 2.3.1.135) is an enzyme that catalyzes the chemical ... The systematic name of this enzyme class is phosphatidylcholine:retinol---[cellular-retinol-binding-protein] O-acyltransferase ... Other names in common use include lecithin---retinol acyltransferase, phosphatidylcholine:retinol-(cellular-retinol-binding- ... the two substrates of this enzyme are phosphatidylcholine and [[retinol---[cellular-retinol-binding-protein]]], whereas its two ...
https://en.wikipedia.org/wiki/Phosphatidylcholineā€”retinol_O-acyltransferase
Phosphatidylcholine-sterol O-acyltransferasePhosphatidylcholine-sterol O-acyltransferase
In enzymology, a phosphatidylcholine---sterol O-acyltransferase (EC 2.3.1.43) is an enzyme that catalyzes the chemical reaction ... The systematic name of this enzyme class is phosphatidylcholine:sterol O-acyltransferase. Other names in common use include ... the two substrates of this enzyme are phosphatidylcholine and sterol, whereas its two products are 1-acylglycerophosphocholine ... phosphatidylcholine + a sterol ā‡Œ {\displaystyle \rightleftharpoons } 1-acylglycerophosphocholine + a sterol ester Thus, ...
https://en.wikipedia.org/wiki/Phosphatidylcholineā€”sterol_O-acyltransferase
GlycerophospholipidGlycerophospholipid
Phosphatidylcholines Phosphatidylcholines are lecithins. Choline is the alcohol, with a positively charged quaternary ammonium ... By contrast, the exoplasmic side (the side on the exterior of the cell) consists mainly of phosphatidylcholine and ... Phosphatidic acid synthesis in eukaryotes is different, there are two routes, one to the other toward phosphatidylcholine and ... Phosphatidylethanoamines, phosphatidylcholines, and other phospholipids are examples of phosphatidates. ...
https://en.wikipedia.org/wiki/Glycerophospholipid
2-acylglycerophosphocholine O-acyltransferase2-acylglycerophosphocholine O-acyltransferase
Van Den Bosch H, Van Golde MG, Slotboom AJ, Van Deenen LL (1968). "The acylation of isomeric monoacyl phosphatidylcholines". ... phosphatidylcholine Thus, the two substrates of this enzyme are acyl-CoA and 2-acyl-sn-glycero-3-phosphocholine, whereas its ... two products are CoA and phosphatidylcholine. This enzyme belongs to the family of transferases, specifically those ...
https://en.wikipedia.org/wiki/2-acylglycerophosphocholine_O-acyltransferase
1-Lysophosphatidylcholine1-Lysophosphatidylcholine
1-LysoPC can be produced as a by-product of the reaction transferring an acyl group from a phosphatidylcholine to an acceptor ... Because they result from the hydrolysis of an acyl group from the sn-1 position of phosphatidylcholine, they are also called 1- ... A rat enzyme was found to transfer the acyl group from 2-lysoPC to 1-lysoPC, producing phosphatidylcholine. In the human body, ... LRAT-like protein (RLP-1; a product of the gene HRASLS5), catalyzes transfer of an acyl group from phosphatidylcholine (PC) to ...
https://en.wikipedia.org/wiki/1-Lysophosphatidylcholine
CiticolineCiticoline
... produces phosphatidylcholine when condensed with diacylglycerol. Phosphatidylcholine can also be produced by the methylation ... Phosphatidylcholine is synthesized in vivo by two pathways The Kennedy pathway, which includes the transformation of choline to ... Citicoline increases phosphatidylcholine synthesis. The mechanism for this may be: By converting 1, 2-diacylglycerol into ... Phosphatidylcholine is a major phospholipid in eukaryotic cell membranes. Close regulation of its biosynthesis, degradation, ...
https://en.wikipedia.org/wiki/Citicoline
Phosphatidylethanolamine N-methyltransferasePhosphatidylethanolamine N-methyltransferase
16 September 2013). "Phosphatidylcholine and Related Lipids". AOCS Lipid Library. AOCS. Archived from the original on 11 ... Li Z, Agellon LB, Allen TM, Umeda M, Jewell L, Mason A, Vance DE (May 2006). "The ratio of phosphatidylcholine to ... DeLong CJ, Shen YJ, Thomas MJ, Cui Z (Oct 1999). "Molecular distinction of phosphatidylcholine synthesis between the CDP- ... Yao ZM, Vance DE (Feb 1988). "The active synthesis of phosphatidylcholine is required for very low density lipoprotein ...
https://en.wikipedia.org/wiki/Phosphatidylethanolamine_N-methyltransferase
Choline kinaseCholine kinase
Phosphatidylcholine is the major phospholipid in eukaryotic membranes. Phosphatidylcholine is important for a variety of ... Li Z, Agellon LB, Allen TM, Umeda M, Jewell L, Mason A, Vance DE (May 2006). "The ratio of phosphatidylcholine to ... Kent C (1990). "Regulation of phosphatidylcholine biosynthesis". Progress in Lipid Research. 29 (2): 87-105. doi:10.1016/0163- ... Choline kinase catalyzes the formation of phoshocholine, the committed step in phosphatidylcholine biosynthesis. ...
https://en.wikipedia.org/wiki/Choline_kinase
POPCPOPC
... is a phosphatidylcholine. It is a diacylglycerol and phospholipid. The full name is 1-palmitoyl-2-oleoyl-sn-glycero-3- ...
https://en.wikipedia.org/wiki/POPC
Carotenoid complexCarotenoid complex
Lycopene - phosphatidylcholine - anti-inflammatory whey protein isolate. Lycopene - phosphatidylcholine - trans-resveratrol: ... phosphatidylcholine - simvastatin LycoD3, Lycopene - phosphatidylcholine - vitamin D3: 6 fold improvement in pharmacokinetics ... The lycopene and phosphatidylcholine complex with vitamin D3 is able not only to protect it from stomach acidity but also to ... Phospholipids, in particular phosphatidylcholine, play a critical role in this process as scaffolding for lipids, proteins and ...
https://en.wikipedia.org/wiki/Carotenoid_complex
Lipid bilayer phase behaviorLipid bilayer phase behavior
In a phosphatidylcholine-based bilayer this process typically occurs over a timescale of weeks. This discrepancy can be ... Saturated phosphatidylcholine lipids with tails longer than 14 carbons are solid at room temperature, while those with fewer ... "Lateral diffusion in binary mixtures of cholesterol and phosphatidylcholines". Proceedings of the National Academy of Sciences ...
https://en.wikipedia.org/wiki/Lipid_bilayer_phase_behavior
DipalmitoylphosphatidylcholineDipalmitoylphosphatidylcholine
Currently, these liposomes are used in the study of the properties of this phosphatidylcholine and of its use as a mechanism of ... Ashton, M. R.; Postle, A. D.; Hall, M. A.; Smith, S. L.; Kelly, F. J.; Normand, I. C. (April 1992). "Phosphatidylcholine ... DPPC is a variant of phosphatidylcholine. Its structure includes both a hydrophilic "head" and hydrophobic "tails", and it is ... More specifically, it has been found that phosphatidylcholine (PC) is the most abundant phospholipid (70%-85%), and that PC is ...
https://en.wikipedia.org/wiki/Dipalmitoylphosphatidylcholine
CholineCholine
Phosphatidylcholines are needed for the synthesis of VLDLs: 70-95% of their phospholipids are phosphatidylcholines in humans. ... For example, phosphatidylcholines (PC) can be hydrolyzed to choline (Chol) in most cell types. Choline can also be produced by ... Phosphatidylcholine levels in the plasma of fasting adults is 1.5-2.5 mmol/L. Its consumption elevates the free choline levels ... Phosphatidylcholines are excreted into bile and work together with bile acid salts as surfactants in it, thus helping with the ...
https://en.wikipedia.org/wiki/Choline
PLA2G6PLA2G6
Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. Model organisms have been used in the study of PLA2G6 ... helps to regulate the levels of a compound called phosphatidylcholine, which is abundant in the cell membrane. The encoded ...
https://en.wikipedia.org/wiki/PLA2G6
PhosphorylcholinePhosphorylcholine
Also not to be confused with phosphatidylcholine. Phosphorylcholine (abbreviated ChoP) is the hydrophilic polar head group of ... Phosphorylcholine is part of platelet-activating factor; the phospholipid phosphatidylcholine as well as sphingomyelin, the ...
https://en.wikipedia.org/wiki/Phosphorylcholine
LecithinLecithin
Because it contains phosphatidylcholines, lecithin is a source of choline, an essential nutrient. There is no clinical evidence ... In 1850, he named the phosphatidylcholine lĆ©cithine. Gobley originally isolated lecithin from egg yolk - Ī»Ī­ĪŗĪ¹ĪøĪæĻ‚ (lekithos) is ... Some phospholipids, such as phosphatidylcholine, have good solubility in ethanol, whereas most other phospholipids do not ... Complex mixture of phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidic acid, glycolipids, etc. ...
https://en.wikipedia.org/wiki/Lecithin
Legionella bozemanaeLegionella bozemanae
"Legionella bozemanae synthesizes phosphatidylcholine from exogenous choline". Microbiological Research. 166 (2): 87-98. doi: ...
https://en.wikipedia.org/wiki/Legionella_bozemanae
Ras GTPaseRas GTPase
Injection increases synthesis of diacylglycerol from phosphatidylcholine. Some meiosis effects are antagonized by rap1 (and by ...
https://en.wikipedia.org/wiki/Ras_GTPase
Injection lipolysisInjection lipolysis
This practice, using drugs generally based on phosphatidylcholine and deoxycholate (PCDC), evolved from the initial intravenous ... 2004). "Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review". Dermatologic Surgery. 30 (3 ... "The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads". Dermatologic Surgery. 27 (4): ... "Phosphatidylcholine in the treatment of localized fat". Journal of Drugs in Dermatology. 2 (5): 511-8. PMID 14558399.{{cite ...
https://en.wikipedia.org/wiki/Injection_lipolysis
List of EC numbers (EC 5)List of EC numbers (EC 5)
... phosphatidylcholine-retinol O-acyltransferase; EC 3.1.1.64, retinoid isomerohydrolase; and EC 1.1.1.315, 11-cis-retinol ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_5)
Phospholipase D1Phospholipase D1
Phosphatidylcholine (PC)-specific phospholipases D (PLDs) EC 3.1.4.4 catalyze the hydrolysis of PC to produce phosphatidic acid ... "Entrez Gene: PLD1 phospholipase D1, phosphatidylcholine-specific". Andersson L, Bostrƶm P, Ericson J, Rutberg M, Magnusson B, ... December 1995). "Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly ...
https://en.wikipedia.org/wiki/Phospholipase_D1
MetribuzinMetribuzin
"Reduced metribuzin pollution with phosphatidylcholine-clay formulations". Pest Management Science. 67 (3): 271-278. doi:10.1002 ...
https://en.wikipedia.org/wiki/Metribuzin
PLA2G5PLA2G5
Kim KP, Han SK, Hong M, Cho W (2000). "The molecular basis of phosphatidylcholine preference of human group-V phospholipase A2 ... It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce ...
https://en.wikipedia.org/wiki/PLA2G5
Furan fatty acidsFuran fatty acids
Batna, A; Spiteller, G (1994). "Effects of soybean lipoxygenase-1 on phosphatidylcholines containing furan fatty acids". Lipids ...
https://en.wikipedia.org/wiki/Furan_fatty_acids
Role of Acyl Chain Composition of Phosphatidylcholine in Tafazzin-Mediated Remodeling of Cardiolipin in LiposomesRole of Acyl Chain Composition of Phosphatidylcholine in Tafazzin-Mediated Remodeling of Cardiolipin in Liposomes
The results of mechanistic studies on the tafazzin-mediated transacylation from phosphatidylcholine (PC) to monolyso-CL (MLCL) ... Role of Acyl Chain Composition of Phosphatidylcholine in Tafazzin-Mediated Remodeling of Cardiolipin in Liposomes Biochemistry ... The results of mechanistic studies on the tafazzin-mediated transacylation from phosphatidylcholine (PC) to monolyso-CL (MLCL) ...
https://pubmed.ncbi.nlm.nih.gov/29091407/
Ask the Pharmacist: 5 people who need more phosphatidylcholineAsk the Pharmacist: 5 people who need more phosphatidylcholine
Fatigue is a challenging issue for people, and its hard to test for a root cause beyond standard adrenal and thyroid function tests.
https://www.marconews.com/story/life/2019/11/11/ask-pharmacist-5-people-who-need-more-phosphatidylcholine/2519691001/
Phosphatidylcholine-Sterol O-Acyltransferase | Harvard Catalyst Profiles | Harvard CatalystPhosphatidylcholine-Sterol O-Acyltransferase | Harvard Catalyst Profiles | Harvard Catalyst
Phosphatidylcholine-Sterol O-Acyltransferase*Phosphatidylcholine-Sterol O-Acyltransferase. *O-Acyltransferase, ... "Phosphatidylcholine-Sterol O-Acyltransferase" is a descriptor in the National Library of Medicines controlled vocabulary ... This graph shows the total number of publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in ... Below are the most recent publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in Profiles. ...
https://connects.catalyst.harvard.edu/Profiles/display/Concept/Phosphatidylcholine-Sterol%20O-Acyltransferase
Phosphatidylcholine (PC) Supplement | BodyBioPhosphatidylcholine (PC) Supplement | BodyBio
BodyBio PC (Phosphatidylcholine) Details: What It Is and How to Take It BodyBio PC (Phosphatidylcholine)s Role in the Body. ... What To Expect When You Start Taking BodyBio PC (Phosphatidylcholine) supplements. 0-2 Weeks. As with any supplement or new ... "Phosphatidylcholine is a key nutrient for your brain, for your myelin, for your mitochondria, its great for detox, its great ... Phosphatidylcholine (PC) - ensures cell membrane integrity and function*. *Phosphatidylethanolamine (PE) - vital to ...
https://bodybio.com/collections/immune-detox/products/bodybio-pc-phosphatidylcholine?variant=34379596005511
L -a-Phosphatidylcholine egg yolk, Type XVI-E, = 99 TLC, lyophilized powder 8002-43-5L -a-Phosphatidylcholine egg yolk, Type XVI-E, = 99 TLC, lyophilized powder 8002-43-5
3-sn-Phosphatidylcholine,L-Ī±-Lecithin,Azolectin,PC; find Sigma-Aldrich-P3556 MSDS, related peer-reviewed papers, technical ... L-Ī±-Phosphatidylcholine egg yolk, Type XVI-E, ā‰„99% (TLC), lyophilized powder; CAS Number: 8002-43-5; EC Number: 232-307-2; ... L-Ī±-Phosphatidylcholine has been used:. *to form a thin lipid film used in Kupffer cell depletion by liposome-encapsulated ... Phosphatidylcholine belongs to the class of glycerophoshpolipids and contains choline as the head-group. Choline is attached to ...
https://www.sigmaaldrich.com/VN/en/product/sigma/p3556
Binding and dynamics of melatonin at the interface of phosphatidylcholine-cholesterol membranesBinding and dynamics of melatonin at the interface of phosphatidylcholine-cholesterol membranes
... ... CitationHuixia, L.; Marti, J. Binding and dynamics of melatonin at the interface of phosphatidylcholine-cholesterol membranes ...
https://upcommons.upc.edu/handle/2117/172822
Bioactive oxidized phosphatidylcholines cause apoptotic cell death in cardiomyocytes during ischemia reperfusionBioactive oxidized phosphatidylcholines cause apoptotic cell death in cardiomyocytes during ischemia reperfusion
... ... Using in vitro model of IR, our goal was to identify oxidized phosphatidylcholines (OxPC) from cardiomyocytes, to determine ...
https://mspace.lib.umanitoba.ca/xmlui/handle/1993/30363
PRIME PubMed | In vitro effects of phosphatidylcholine and transgalactooligosaccharides on the production of 1,2-sn...PRIME PubMed | In vitro effects of phosphatidylcholine and transgalactooligosaccharides on the production of 1,2-sn...
In vitro effects of phosphatidylcholine and transgalactooligosaccharides on the production of 1,2-sn-diacylglycerol by ... Microbial species involved in production of 1,2-sn-diacylglycerol and effects of phosphatidylcholine on human fecal microbiota. ... TY - JOUR T1 - In vitro effects of phosphatidylcholine and transgalactooligosaccharides on the production of 1,2-sn- ... In vitro effects of phosphatidylcholine and transgalactooligosaccharides on the production of 1,2-sn-diacylglycerol by ...
https://www.unboundmedicine.com/medline/citation/18828790/In_vitro_effects_of_phosphatidylcholine_and_transgalactooligosaccharides_on_the_production_of_12_sn_diacylglycerol_by_Bifidobacterium_longum_biovar_infantis_
Phosphatidylcholine metabolism in neonatal mouse calvaria<...
title = "Phosphatidylcholine metabolism in neonatal mouse calvaria",. abstract = "Phosphatidylcholine metabolism was examined ... the rate of phosphatidylcholine production through this pathway appeared to be too slow to account for the phosphatidylcholine ... the rate of phosphatidylcholine production through this pathway appeared to be too slow to account for the phosphatidylcholine ... the rate of phosphatidylcholine production through this pathway appeared to be too slow to account for the phosphatidylcholine ...
https://www.scholars.northwestern.edu/en/publications/phosphatidylcholine-metabolism-in-neonatal-mouse-calvaria
Bombesin and platelet-derived growth factor stimulate phosphatidylcholine breakdown by a common mechanism - Fingerprint -...Bombesin and platelet-derived growth factor stimulate phosphatidylcholine breakdown by a common mechanism - Fingerprint -...
Dive into the research topics of Bombesin and platelet-derived growth factor stimulate phosphatidylcholine breakdown by a ... Bombesin and platelet-derived growth factor stimulate phosphatidylcholine breakdown by a common mechanism. ...
https://pureportal.strath.ac.uk/en/publications/bombesin-and-platelet-derived-growth-factor-stimulate-phosphatidy/fingerprints/
Dr. Russell Jaffe on Phosphatidylcholine - PERQUEDr. Russell Jaffe on Phosphatidylcholine - PERQUE
What is Phosphatidylcholine? How is it used in the body? On this edition of Ask Dr. J, Dr. Russell Jaffe answers those ... What is Phosphatidylcholine? How is it used in the body? On this edition of "Ask Dr. J", Dr. Russell Jaffe answers those ... Russell Jaffe on Phosphatidylcholine. In Ask Dr. J, News by Justin Welton. February 4, 2021. ...
https://www.perque.com/dr-russell-jaffe-on-phosphatidylcholine/
Flexible loops of thread-like micelles are formed upon interaction of L-?-dimyristoyl-phosphatidylcholine with the...Flexible loops of thread-like micelles are formed upon interaction of L-?-dimyristoyl-phosphatidylcholine with the...
Flexible loops of thread-like micelles are formed upon interaction of L-?-dimyristoyl-phosphatidylcholine with the ... Flexible loops of thread-like micelles are formed upon interaction of L-?-dimyristoyl-phosphatidylcholine with the ... Flexible loops of thread-like micelles are formed upon interaction of L-?-dimyristoyl-phosphatidylcholine with the ...
https://www.bcp.fu-berlin.de/en/chemie/chemie/forschung/OrgChem/ludwig/veroeffentlichungen/_Publikationen_Inhalt/2010/098/index.html
Bilayer polarity and its thermal dependency in the ā„“o and ā„“d phases of binary phosphatidylcholine/cholesterol mixtures | - CCMARBilayer polarity and its thermal dependency in the ā„“o and ā„“d phases of binary phosphatidylcholine/cholesterol mixtures | - CCMAR
Bilayer polarity and its thermal dependency in the ā„“o and ā„“d phases of binary phosphatidylcholine/cholesterol mixtures. ...
https://ccmar.ualg.pt/biblio/bilayer-polarity-and-its-thermal-dependency-lo-and-ld-phases-binary
Topical skin cream comprising phosphatidylcholine dha and l-tyrosine - Patent US-2011306577-A1 - PubChemTopical skin cream comprising phosphatidylcholine dha and l-tyrosine - Patent US-2011306577-A1 - PubChem
US-2011306577-A1 chemical patent summary.
https://pubchem.ncbi.nlm.nih.gov/patent/US-2011306577-A1
Metabolic and Structural Effects of Phosphatidylcholine and Deoxycholate Injections on Subcutaneous Fat: A Randomized,...
Metabolic and Structural Effects of Phosphatidylcholine and Deoxycholate Injections on Subcutaneous Fat: A Randomized, ... Metabolic and Structural Effects of Phosphatidylcholine and Deoxycholate Injections on Subcutaneous Fat: A Randomized, ... Metabolic and Structural Effects of Phosphatidylcholine and Deoxycholate Injections on Subcutaneous Fat: A Randomized, ...
https://www.aserf.org/final-reports/metabolic-and-structural-effects-of-phosphatidylcholine-and-deoxycholate-injections-on-subcutaneous-fat-a-randomized-controlled-trial
Bacterial Inhibition of Phosphatidylcholine Synthesis Triggers Apoptosis in the Brain | Journal of Experimental Medicine |...Bacterial Inhibition of Phosphatidylcholine Synthesis Triggers Apoptosis in the Brain | Journal of Experimental Medicine |...
Bacterial Inhibition of Phosphatidylcholine Synthesis Triggers Apoptosis in the Brain Janine Zweigner, Janine Zweigner ... Lyso-Phosphatidylcholine (lyso-PC) Prevents Pneumococcal Apoptosis in Microglia and Neurons. To determine whether the ... Phosphatidylcholine (PtdCho) is a major component of eukaryotic cell membranes. Its biosynthesis occurs mainly via the cytidine ... Phosphatidylcholine (PtdCho) is an essential component of mammalian cell membranes and PtdCho deficiency, either due to ...
https://rupress.org/jem/article/200/1/99/40084/Bacterial-Inhibition-of-Phosphatidylcholine
Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane...Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane...
Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane ... Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane ...
https://publikationen.uni-tuebingen.de/xmlui/handle/10900/38982
Partitioning of perfluorooctanoate into phosphatidylcholine bilayers i by Wei Xie, Geoffrey D. Bothun et al."Partitioning of perfluorooctanoate into phosphatidylcholine bilayers i" by Wei Xie, Geoffrey D. Bothun et al.
These findings suggest that PFOAs effect on the phase behavior of phosphatidylcholines depends on the cooperativity and state ... its relative effect on the phase behavior was largely independent of the phosphatidylcholine. PFOA caused swelling of DMPC but ... the main phase transition temperature Tm while increasing the width of the phase transition of all three phosphatidylcholines. ... These findings suggest that PFOAs effect on the phase behavior of phosphatidylcholines depends on the cooperativity and state ...
https://digitalcommons.uri.edu/che_facpubs/46/
Reorientational and conformational ordering processes at elevated pressures in 1,2-Dioleoyl phosphatidylcholine - NRC...Reorientational and conformational ordering processes at elevated pressures in 1,2-Dioleoyl phosphatidylcholine - NRC...
Reorientational and conformational ordering processes at elevated pressures in 1,2-Dioleoyl phosphatidylcholine. DOI. Resolve ... Raman and infrared spectra of fully hydrated bilayers of 1,2-dioleoyl phosphatidylcholine (DOPC) were measured at increasing ... Reorientational and conformational ordering processes at elevated pressures in 1,2-Dioleoyl phosphatidylcholine. From National ...
https://nrc-publications.canada.ca/eng/view/object/?id=efbb7e26-d197-492c-842d-f973b7115c5d
10-(perfluorobutyl)decyl phosphatidylcholine Properties, Molecular Formula, Applications - WorldOfChemicals10-(perfluorobutyl)decyl phosphatidylcholine Properties, Molecular Formula, Applications - WorldOfChemicals
... decyl phosphatidylcholine. Get 10-(perfluorobutyl)decyl phosphatidylcholine molecular formula, CAS number, boiling point, ...
https://www.worldofchemicals.com/chemicals/chemical-properties/10-perfluorobutyldecyl-phosphatidylcholine.html
PC (Phosphatidylcholine)PC (Phosphatidylcholine)
... $49.99 60CT - $49.99 USD 100CT - $74.99 USD 16oz - $189.99 USD OVERVIEW BodyBio PC combines four ... Phosphatidylcholine (PC) - ensures cell membrane integrity and function*. Phosphatidylethanolamine (PE) - vital to ... Since PC decreases as we age, more doctors are recommending supplementation with phosphatidylcholine to ensure were keeping ... studies show that increased levels of Phosphatidylcholine (PC) can help the body heal while also improving brain function, ...
https://drkimwellness.com/products/pc-phosphatidylcholine
Phosphatidylcholine Archives - PhosphatidylcholinePhosphatidylcholine Archives - Phosphatidylcholine
Phosphatidylcholine. Phosphatidylcholine Information and its Role in Healthy Aging Subscribe by: RSS ā˜… Phosphatidylcholine is ... Welcome to Phosphatidylcholine Dot Org We will be providing information about the wonderful phospholipid Phosphatidylcholine, ... Phosphatidylcholine is an integral component of every cell in the human body. Consumed regulalry as part of our normal diets, ... "Phosphatidylcholine addresses all by itself a major aging process. This is because that substances depletes from your cell ...
https://www.phosphatidylcholine.org/tag/phosphatidylcholine/
Phosphatidylcholine - Milltown PharmacyPhosphatidylcholine - Milltown Pharmacy
Soy-free, GMO-free, sunflower-derived phosphatidylcholine.. *Major source of methyl groups to promote healthy methylation, ... Soy-free, GMO-free, sunflower-derived phosphatidylcholine.. *Major source of methyl groups to promote healthy methylation, ...
https://milltownpharmacy.com/product/phosphatidylcholine/
phosphatidylcholine - Brett Combsphosphatidylcholine - Brett Combs
Tag / phosphatidylcholine February 13, 2019. February 13, 2019. by Brett Combs Your 100 Trillion Cells Need Phosphatidylcholine ...
https://brettcombs.com/tag/phosphatidylcholine/
IMSEAR at SEARO: Characteristics of phosphatidylcholine/peptidylglycolipid liposomes.
Characteristics of phosphatidylcholine/peptidylglycolipid liposomes. Indian Journal of Biochemistry & Biophysics. 1984 Feb; 21( ...
https://imsear.searo.who.int/handle/123456789/28978
phosphatidylcholine Archives - Echelon Biosciencesphosphatidylcholine Archives - Echelon Biosciences
675 Arapeen Dr. Ste 302 Salt Lake City, UT 84108 - 801-588-0455. ...
https://www.echelon-inc.com/product-tag/phosphatidylcholine/?filter_categories=biochemical-reagents
Unexpected depletion in plasma choline and phosphatidylcholine concentrations in a pregnant woman with bipolar affective...Unexpected depletion in plasma choline and phosphatidylcholine concentrations in a pregnant woman with bipolar affective...
During pregnancy, plasma concentrations of choline and phosphatidylcholine are increased to meet the demands of the foetus. ... However, our findings in this case included depletion of plasma choline and phosphatidylcholine concentrations. Other unusual ... Our data analysis was limited by the lack of information on the actual amounts of choline and phosphatidylcholine that were ... Phosphatidylcholine, for example, supplies important long chain polyunsaturated fatty acids, and deficiency of polyunsaturated ...
https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-2-55
Natures Way Vitamin B6 50 mg - NutriveneNature's Way Vitamin B6 50 mg - Nutrivene
Allergy Research Phosphatidyl Choline 385 mg. $25.49. Add to cart. * Longevity Science MK-7 Vitamin K2. $17.95. ...
https://www.nutrivene.com/product/natures-way-vitamin-b6/
Biotics Research, Phosphatidylcholine - 100 Softgel CapsulesBiotics Research, Phosphatidylcholine - 100 Softgel Capsules
Phosphatidylcholine is a major constituent of cell membranes, and is important for normal cellular membrane function and repair ... Phosphatidylcholine supplies a supplemental source of this important phospholipid. ... Phosphatidylcholine supplies a supplemental source of this important phospholipid. Phosphatidylcholine is a major constituent ... Each softgel capsule contains 1,200 mg of lecithin providing 420mg of phosphatidylcholine. Phosphatidylcholine (from soy ...
https://popularvitamin.com/biotics-research-phosphatidylcholine-100-softgel-capsules.html
Phosphatidylcholine powder 300 gr | Vitalakosttillskott.se
Phosphatidylcholine Powder (PC) innehƄller fosfatidylkolin, vilken Ƥr en av de viktigaste nƤringsƤmnena som krƤvs fƶr hƤlsa. ... Phosphatidylcholine Powder (PC) innehƄller fosfatidylkolin, vilken Ƥr en av de viktigaste nƤringsƤmnena som krƤvs fƶr hƤlsa. ... Bli fƶrst med att recensera "Phosphatidylcholine powder 300 gr" Avbryt svar. Din e-postadress kommer inte publiceras. ... Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model ...
https://vitalakosttillskott.se/produkt/phosphatidylcholine-powder/
LecithinCholineLiposomesLipidsDPPCPhosphatidylserineLyso-phosphatidylcholineBilayersExtractCholesterolPtdChoAcyltransferaseSunflowerPowderSynthesisPhospholipidsBiosynthesisMembranes2016NutrientVitroSupplementationAgingLipolysisConcentrationsFattyCellLiverAbsorptionBioavailabilityImproving brainImportant
Lecithin7
  • Each softgel capsule contains 1,200 mg of lecithin providing 420mg of phosphatidylcholine. (popularvitamin.com)
  • Phosphatidylcholine (from soy lecithin). (popularvitamin.com)
  • NATURAL FACTORS - Phosphatidyl Choline - 90 Softgel(s) - NPN: 80023613 -- Phosphatidyl Choline (also referred to as phosphatidylcholine) is a preferred form of choline derived directly from lecithin. (goodhealthmarthamilton.com)
  • Polyunsaturated Phosphatidylcholine is a liquid form of lecithin, which is an enzyme naturally produced in our body. (mesotherapy-solutions.com)
  • Dipalmitoyl phosphatidylcholine (DPPC), or lecithin, is functionally the principle phospholipid. (medscape.com)
  • Lecithin is a source of phosphatidylcholine, the phospholipid found in cell membranes. (myvitalab.com)
  • In addition to this, the lecithin extracted from soybean oil comprises three forms of phospholipids -phosphatidylinositol (PI), phosphatidylcholine (PC), and phosphatidylethanolamine (PE), which make it highly sought-after throughout the world. (dejavekita.com)
Choline8
  • Phosphatidylcholine belongs to the class of glycerophoshpolipids and contains choline as the head-group. (sigmaaldrich.com)
  • Phosphatidylcholine is produced in the liver by the CDP-choline (cytidine diphosphocholine) pathway. (sigmaaldrich.com)
  • Incorporation of choline into phosphatidylcholine was slow in this tissue. (northwestern.edu)
  • Although rates of choline-phosphatidylcholine base exchange were higher in bone microsomes than in microsomes from liver, the rate of phosphatidylcholine production through this pathway appeared to be too slow to account for the phosphatidylcholine produced by the calvaria. (northwestern.edu)
  • During pregnancy, plasma concentrations of choline and phosphatidylcholine are increased to meet the demands of the foetus. (biomedcentral.com)
  • However, our findings in this case included depletion of plasma choline and phosphatidylcholine concentrations. (biomedcentral.com)
  • Choline is a nutrient that is a precursor of phosphatidylcholine and the plasma concentrations of both nutrients are controlled by endogenous synthesis and dietary intake [ 1 ]. (biomedcentral.com)
  • Patients with bipolar affective disorder are effectively managed with pharmacological intervention, such as lithium, haloperidol and benztropine, but studies on the influence of these drugs on plasma choline and phosphatidylcholine concentrations are limited. (biomedcentral.com)
Liposomes5
  • IMSEAR at SEARO: Characteristics of phosphatidylcholine/peptidylglycolipid liposomes. (who.int)
  • The experiments on the spontaneously hypertensive rats show that both single and long-term injections of phosphatidylcholine liposomes (PCL) cause a significant decrease in blood pressure. (dp.ua)
  • Such a hypotensive effect correlated with a dose of phosphatidylcholine liposomes. (dp.ua)
  • Dimeric Artesunate-Phosphatidylcholine-Based Liposomes for Irinotecan Delivery as a Combination Therapy Approach. (bvsalud.org)
  • In this work , dimeric artesunate - phosphatidylcholine conjugate (dARTPC)-based liposomes encapsulated with irinotecan (Ir) were developed for anticancer combination therapy . (bvsalud.org)
Lipids2
  • Recently, several types of synthetic lipids that have headgroups with the opposite charge to that of phosphatidylcholine have emerged, i.e., a positively charged ammonium group is present adjacent to the ester linkage in their glycerol moiety and a negatively charged group is placed at their terminus. (datapdf.com)
  • The aim of this study was to determine how such lipids, with antiparallel arranged headgroup charge, interact with naturally occurring phosphatidylcholines. (datapdf.com)
DPPC2
  • 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) was used to represent a naturally occurring phospholipid. (datapdf.com)
  • Research has found that dipalmitoyl phosphatidylcholine (DPPC). (cdc.gov)
Phosphatidylserine1
  • Erythrocytes infected with Plasmodium falciparum or Plasmodium knowlesi efficiently incorporated radioactive serine into phosphatidylserine (PtdSer), phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho). (unipr.it)
Lyso-phosphatidylcholine1
  • Supplementation with exogenous lyso-phosphatidylcholine prevents cell death and treatment of mice with cytidine diphosphocholine attenuates hippocampal damage during meningitis, even after the onset of infection. (rupress.org)
Bilayers2
  • Partitioning of perfluorooctanoate into phosphatidylcholine bilayers i" by Wei Xie, Geoffrey D. Bothun et al. (uri.edu)
  • Raman and infrared spectra of fully hydrated bilayers of 1,2-dioleoyl phosphatidylcholine (DOPC) were measured at increasing hydrostatic pressures up to -37 kbar. (canada.ca)
Extract1
  • To overcome this, MerivaĀ® uniquely binds curcumin extract to the lipid molecule - phosphatidylcholine - creating a phytosome form, with increased absorption and bioavailability. (thepowermall.com)
Cholesterol6
  • Ceramides and phosphatidylcholines were analyzed using a LC-MS. Total cholesterol and triglycerides were performed by enzymatic methods and HDL cholesterol was determined by a direct enzymatic method. (vtt.fi)
  • Uptake of cholesterol by isolated rat hepatocytes in a serum-free medium was remarkably enchanced by dispersion with several kinds of phosphatidylcholine. (fujita-hu.ac.jp)
  • The abilities to accelerate cholesterol uptake were in proportion to the content of unsaturated fatty acid in the phosphatidylcholine used. (fujita-hu.ac.jp)
  • It was confirmed by electron microscopy that there is no relation between the size of the cholesterol-phosphatidylcholine complex and uptake. (fujita-hu.ac.jp)
  • These data suggest that recognition of unsaturated fatty acids in phosphatidylcholine by isolated cells enhances uptake of cholesterol. (fujita-hu.ac.jp)
  • Cholesterol uptake (Isolated rat hepatocyte) Phosphatidylcholine Unsaturated fatty acid Dioleoylphosphatidylcholine Dipalmitoylphosphatidylcholine. (fujita-hu.ac.jp)
PtdCho2
  • PtdCho, phosphatidylcholine. (rupress.org)
  • Phosphatidylcholine (PtdCho) is an essential component of mammalian cell membranes and PtdCho deficiency, either due to chemicals or altered nutrition, leads to apoptosis, especially in hippocampal neurons. (rupress.org)
Acyltransferase3
  • Phosphatidylcholine-Sterol O-Acyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in Harvard Catalyst Profiles by year, and whether "Phosphatidylcholine-Sterol O-Acyltransferase" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in Profiles. (harvard.edu)
Sunflower1
Powder2
  • Phosphatidylcholine Powder (PC) innehĆ„ller fosfatidylkolin, vilken Ƥr en av de viktigaste nƤringsƤmnena som krƤvs fƶr hƤlsa. (vitalakosttillskott.se)
  • Phosphatidylcholine powder is excellent for emulsifying fat, making this nutrient extremely valuable for liver health. (curatedwellness.com)
Synthesis4
  • No evidence for significant phosphatidylcholine synthesis through the methylation pathway was found in the calvarial tissue. (northwestern.edu)
  • Phosphatidylcholine synthesis in the calvaria was unaffected by 2 h of treatment of 10 nM-parathyroid hormone, 0.1 nM-0.1 Ī¼M-1Ī±,25-dihydroxycholecalciferol, 5 Ī¼M-prostaglandin E 1 or 2.5 nM-salmon calcitonin, or by 17 h of treatment with 10 nM-parathyroid hormone or 0.1 nM-1Ī±,25-dihydroxycholecalciferol. (northwestern.edu)
  • Phosphatidylcholine synthesis in the calvaria was unaffected by 2 h of treatment of 10 nM-parathyroid hormone, 0.1 nM-0.1 Ī¼M-1Ī±,25-dihydroxycholecalciferol, 5 Ī¼M-prostaglandin E1 or 2.5 nM-salmon calcitonin, or by 17 h of treatment with 10 nM-parathyroid hormone or 0.1 nM-1Ī±,25-dihydroxycholecalciferol. (northwestern.edu)
  • Influence of host factors on phosphatidylcholine synthesis in Schistosoma mansoni / by Bruce W. Young. (who.int)
Phospholipids1
  • Krill oil is rich in the long-chain omega-3s eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and more than 80 percent of these two fatty acids are bound to phospholipids, predominantly phosphatidylcholine. (uschinahpa.org)
Biosynthesis1
  • A congenital muscular dystrophy with mitochondrial structural abnormalities caused by defective de novo phosphatidylcholine biosynthesis. (medscape.com)
Membranes4
  • The results of mechanistic studies on the tafazzin-mediated transacylation from phosphatidylcholine (PC) to monolyso-CL (MLCL) in artificial lipid membranes are controversial. (nih.gov)
  • Welcome to Phosphatidylcholine Dot Org We will be providing information about the wonderful phospholipid Phosphatidylcholine, one of the major components of biological cell membranes which is slowly depleted with age. (phosphatidylcholine.org)
  • Phosphatidylcholine is a major constituent of cell membranes, and is important for normal cellular membrane function and repair. (popularvitamin.com)
  • Naturally abundant in cell membranes, phosphatidylcholine breaks down the fat stored in fat cells (adipocytes). (mesotherapy-solutions.com)
20161
  • Sep 19, 2016 - Phosphatidylcholine, a naturally occurring lipid, is the most common lipid found in organisms. (datapdf.com)
Nutrient1
  • PipingRock Mega Phosphatidylcholine brings you this important nutrient in easy-to-swallow softgels, making it easier than ever to get daily support for your wellness routine. (pipingrock.com)
Vitro2
  • Using in vitro model of IR, our goal was to identify oxidized phosphatidylcholines (OxPC) from cardiomyocytes, to determine their bioactivity on cardiomyocyte viability and mitochondrial permeability, and using an OxPC specific EO6 antibody inhibit OxPC activity on cardiomyocytes. (umanitoba.ca)
  • Bifidobacterium longum biovar infantis was grown in vitro using anaerobic static batch cultures in the presence of phosphatidylcholine (PC) and trans-galactooligosaccharides (TOS). (unboundmedicine.com)
Supplementation1
  • Since PC decreases as we age, more doctors are recommending supplementation with phosphatidylcholine to ensure we're keeping our cells, and in turn, entire body healthy at any age. (bodybio.com)
Aging2
  • Inventor, Author, and Futurist Raw Kurzweil on bigthink.com talks about how important Phosphatidylcholine is in its role in aging. (phosphatidylcholine.org)
  • Phosphatidylcholine addresses all by itself a major aging process. (phosphatidylcholine.org)
Lipolysis1
  • Dermaheal LL (lipolytic) solution is a powerful method of injectable lipolysis, enriched with biomimetic peptide, phosphatidylcholine, L-carnitine, which dissolves the excess fat in unreacheable places. (cosmateline.com)
Concentrations1
  • Among women who were not using oral contraceptives or menopausal hormone therapy when the samples were collected (1124 cases and 1124 controls), higher concentrations of acylcarnitine and lower concentrations of arginine, asparagine, and five different phosphatidylcholines were associated with an increased risk of breast cancer. (who.int)
Fatty1
Cell1
Liver3
  • After administration, phosphatidylcholine induces an enzymatic reaction, which leads to the dissolution of fat by producing an emulsion of nano-sized monoglycerides that is transported into the liver and metabolized by beta-oxidation. (mesotherapy-solutions.com)
  • One study noted the combination of milk thistle and phosphatidylcholine exerted antioxidant effects on liver and gastric cells. (purebulk.com)
  • One study found a combination of milk thistle, phosphatidylcholine, and vitamin E supported liver health by improving liver enzymes. (purebulk.com)
Absorption1
  • Phosphatidylcholine facilitates the emulsification of fat into the tiniest particles, enabling the absorption and transportation of fat. (mesotherapy-solutions.com)
Bioavailability1
  • Phosphatidylcholine synergizes with milk thistle by improving the bioavailability of silybin. (purebulk.com)
Improving brain1
  • Whether you're hoping to heal a current health concern like digestive, cognitive or immune function, or prevent future problems, studies show that increased levels of Phosphatidylcholine (PC) can help the body heal while also improving brain function, mental focus, and memory. (bodybio.com)
Important1
  • Phosphatidylcholine supplies a supplemental source of this important phospholipid. (popularvitamin.com)
Ask the Pharmacist: 5 people who need more phosphatidylcholine
Ask the Pharmacist: 5 people who need more phosphatidylcholine (marconews.com)
Overview of COVID-19 Vaccines | CDC
Overview of COVID-19 Vaccines | CDC (cdc.gov)
Ganglioside - WikipƩdia
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LCAT gene: MedlinePlus Genetics
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Nature's Way Vitamin B6 50 mg - Nutrivene
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Pharmaceuticals | Free Full-Text | Cannabinoids and Reproduction: A Lasting and Intriguing History
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Frontiers | Assessing Drought and Heat Stress-Induced Changes in the Cotton Leaf Metabolome and Their Relationship With...
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Frontiers | Exercise-Induced Plasma Metabolomic Profiles in Patients With Peripheral Arterial Disease
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ATSDR - Asbestos Expert Panel - Appendix E
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Nutrients | Free Full-Text | Common Genetic Variants Alter Metabolism and Influence Dietary Choline Requirements
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Respiratory Distress Syndrome: Background, Etiology, Epidemiology
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Respiratory Distress Syndrome Medication: Lung Surfactants
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Recombinant Mouse EGF-containing fibulin-like extracellular matrix protein 1 (Efemp1) | CSB-MP007450MO | Cusabio
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Bacterial microcompartments | Nature Reviews Microbiology
Bacterial microcompartments | Nature Reviews Microbiology (nature.com)
Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders | Nature Reviews Gastroenterology &...
Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders | Nature Reviews Gastroenterology &... (nature.com)
PDF) The Powdering Process with a Set of Ceramic Mills for Green Tea Promoted Catechin Extraction and the ROS Inhibition Effect
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Gut Flora Metabolite Seen to Predict Mortality in HF
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5 Best Immune System Support Supplements to boost your Immunity - Best Bodybuilding, Sexual Health, Weight Loss Supplements And...
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Lecithin-Cholesterol Acyltransferase Deficiency: Overview, Presentation, Differential Diagnosis
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ABCA7 Deficiency Accelerates Amyloid-Ī² Generation and Alzheimer's Neuronal Pathology | Journal of Neuroscience
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Fungal Pneumonia: Overview, Risk Factors, Epidemiology of Fungal Pneumonia
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KEGG REACTION: R01317
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Protein-Energy Malnutrition Workup: Approach Considerations, Laboratory Studies, Other Tests
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KEGG REACTION: R05647
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QCM TD biomoleĢcules 2017-2018 par CASPAR BAUGUIL - Fichier PDF
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Detoxification - Detoxification Supplements & Vitamins - PureCapsPRO.com
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Hypothesis: The Role of Sterols in Autism Spectrum Disorder
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Marine Drugs | Free Full-Text | New Metabolites from the Marine Sponge Scopalina hapalia Collected in Mayotte Lagoon
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Using lipidomics to reveal details of lipid accumulation in developing Siberian apricot (Prunus sibirica L.) seed kernels |...
Using lipidomics to reveal details of lipid accumulation in developing Siberian apricot (Prunus sibirica L.) seed kernels |... (researchsquare.com)