Herbicides
Comamonadaceae
Molecular Structure
Sulfur Compounds
Effect of phenylurea herbicides on soil microbial communities estimated by analysis of 16S rRNA gene fingerprints and community-level physiological profiles. (1/1212)
The effect of three phenyl urea herbicides (diuron, linuron, and chlorotoluron) on soil microbial communities was studied by using soil samples with a 10-year history of treatment. Denaturing gradient gel electrophoresis (DGGE) was used for the analysis of 16S rRNA genes (16S rDNA). The degree of similarity between the 16S rDNA profiles of the communities was quantified by numerically analysing the DGGE band patterns. Similarity dendrograms showed that the microbial community structures of the herbicide-treated and nontreated soils were significantly different. Moreover, the bacterial diversity seemed to decrease in soils treated with urea herbicides, and sequence determination of several DGGE fragments showed that the most affected species in the soils treated with diuron and linuron belonged to an uncultivated bacterial group. As well as the 16S rDNA fingerprints, the substrate utilization patterns of the microbial communities were compared. Principal-component analysis performed on BIOLOG data showed that the functional abilities of the soil microbial communities were altered by the application of the herbicides. In addition, enrichment cultures of the different soils in medium with the urea herbicides as the sole carbon and nitrogen source showed that there was no difference between treated and nontreated soil in the rate of transformation of diuron and chlorotoluron but that there was a strong difference in the case of linuron. In the enrichment cultures with linuron-treated soil, linuron disappeared completely after 1 week whereas no significant transformation was observed in cultures inoculated with nontreated soil even after 4 weeks. In conclusion, this study showed that both the structure and metabolic potential of soil microbial communities were clearly affected by a long-term application of urea herbicides. (+info)Proliferative effects of cholecystokinin in GH3 pituitary cells mediated by CCK2 receptors and potentiated by insulin. (2/1212)
1. Proliferative effects of CCK peptides have been examined in rat anterior pituitary GH3 cells, which express CCK2 receptors. 2. CCK-8s, gastrin(1-17) and its glycine-extended precursor G(1-17)-Gly, previously reported to cause proliferation via putative novel sites on AR4-2J and Swiss 3T3 cells, elicited significant dose dependent increases of similar magnitude in [3H]thymidine incorporation over 3 days in serum-free medium of 39 +/- 10% (P < 0.01, n = 20), 37 +/- 8% (P < 0.01, n = 27) and 41 +/- 6% (P < 0.01, n = 36) respectively. 3. CCK-8s and gastrin potentially stimulated mitogenesis (EC50 values 0.12 nM and 3.0 nM respectively), whilst G-Gly displayed similar efficacy but markedly lower potency. L-365,260 consistently blocked each peptide. The CCK2 receptor affinity of G-Gly in GH3 cells was 1.09 microM (1.01;1.17, n = 6) and 5.53 microM (3.71;5.99, n = 4) in guinea-pig cortex. 4. 1 microM G-Gly weakly stimulated Ca2+ increase, eliciting a 104 +/- 21% increase over basal Ca2+ levels, and was blocked by 1 microM L-365,260 whilst CCK-8s (100 nM) produced a much larger Ca2+ response (331 +/- 14%). 5. Insulin dose dependently enhanced proliferative effects of CCK-8s with a maximal leftwards shift of the CCK-8s curve at 100 ng ml(-1) (17 nM) (EC50 decreased 500 fold, from 0.1 nM to 0.2 pM; P < 0.0001). 10 microg ml(-1) insulin was supramaximal reducing the EC50 to 5 pM (P = 0.027) whilst 1 ng ml(-1) insulin was ineffective. Insulin weakly displaced [125I]BHCCK binding to GH3 CCK2 receptors (IC50 3.6 microM). 6. Results are consistent with mediation of G-Gly effects via CCK2 receptors in GH3 cells and reinforce the role of CCK2 receptors in control of cell growth. Effects of insulin in enhancing CCK proliferative potency may suggest that CCK2 and insulin receptors converge on common intracellular targets and indicates that mitogenic stimuli are influenced by the combination of extracellular factors present. (+info)Taste qualities of solutions preferred by hamsters. (3/1212)
Molecules of diverse chemical structure are sweet to humans and several lines of evidence (genetic, physiological, behavioral) suggest that there may be distinct sweet perceptual qualities. To address how many perceptual categories these molecules elicit in hamsters (Mesocricetus auratus), we studied patterns of generalization of conditioned taste aversions for seven sweeteners: 100 mM sucrose, 320 mM maltose, 32 mM D-phenylalanine, 3.2 mM sodium saccharin, 16 mM calcium cyclamate, 10 mM dulcin and 32 mM sodium m-nitrobenzene sulfonate. Each stimulus was preferred versus water in two-bottle intake tests and stimulated the chorda tympani nerve. For each of seven experimental groups the conditional stimulus (CS) was a sweetener and for the control group the CS was water. Apomorphine.HCl was injected i.p. after a CS was sampled and, after recovery, test stimuli (TS) were presented for 1 h daily. The intake (ml) of each TS consumed by experimental animals was compared with mean TS intake by the control group. Learned aversions for 18/21 stimulus pairs cross-generalized, resulting in a single cluster of generalization patterns for the seven stimuli. Cross-generalization failures (maltose-cyclamate, maltose-sucrose, cyclamate-NaNBS) may be the consequence of particular stimulus features (e.g. salience, cation taste), rather than the absence of a 'sucrose-like' quality. The results are consistent with a single hamster perceptual quality for a diverse set of chemical structures that are sweet to humans. (+info)Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. (4/1212)
The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors for fatty acids (FAs) that regulate glucose and lipid homeostasis. We report the crystal structure of the PPAR delta ligand-binding domain (LBD) bound to either the FA eicosapentaenoic acid (EPA) or the synthetic fibrate GW2433. The carboxylic acids of EPA and GW2433 interact directly with the activation function 2 (AF-2) helix. The hydrophobic tail of EPA adopts two distinct conformations within the large hydrophobic cavity. GW2433 occupies essentially the same space as EPA bound in both conformations. These structures provide molecular insight into the propensity for PPARs to interact with a variety of synthetic and natural compounds, including FAs that vary in both chain length and degree of saturation. (+info)Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-containing lipoprotein and bile acids in HepG2. (5/1212)
We studied the effect of NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl) ureido]methyl]cyclohexane), a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on intracellular cholesterol esterification and the secretion of apolipoprotein B100 (apoB)-containing lipoprotein and bile acids in the human hepatoma cell line HepG2. NTE-122 markably inhibited [3H]oleate incorporation into cholesteryl esters in HepG2 cells incubated with 5 microg/ml 25-hydroxycholesterol as a stimulus for ACAT (IC50=6.0 nM). On the other hand, NTE-122 did not affect [3H]oleate incorporation into triglycerides and phospholipids and [14C]acetate incorporation into cholesterol. The stimulation of ACAT by 25-hydroxycholesterol caused significant increases in the secretion of radiolabeled cholesteryl esters, radiolabeled triglycerides and apoB mass. NTE-122 pronouncedly inhibited the secretion of radiolabeled cholesteryl esters in proportion to the inhibition of cellular cholesterol esterification, and it significantly reduced the secretion of radiolabeled triglycerides and apoB mass in HepG2 cells incubated with 25-hydroxycholesterol. Furthermore, NTE-122 increased the secretion of bile acids synthesized from [14C]-cholesterol. These results suggest that NTE-122 is capable of exhibiting anti-hyperlipidemic effects by reducing both the cholesterol content and the amount of secreted very low-density lipoprotein and enhancing the excretion of bile acid from the liver. (+info)Analysis of the behaviour of selected CCKB/gastrin receptor antagonists in radioligand binding assays performed in mouse and rat cerebral cortex. (6/1212)
1. The previously described complex behaviour of the CCKB/gastrin receptor antagonist, L-365,260, in radioligand binding assays could be explained by a variable population of two binding sites. We have investigated whether other CCKB/gastrin receptor ligands (PD134,308, PD140,376, YM022 and JB93182) can distinguish between these sites. 2. In the mouse cortex assay, Hill slopes were not different from unity and the ligand pKI values did not differ when either [125I]-BH-CCK-8S or [3H]-PD140,376 was used as label as expected for a single site (G2). 3. In the rat cortex, where previous analysis of replicate (n=48) L-365,260 data indicated the presence of two CCKB/gastrin sites (G1 and G2), the competition data for PD134,308, PD140,376, YM022 and JB93182 could be explained by a homogeneous population of CCKB/gastrin sites because the Hill slope estimates were not significantly different from unity. However, the estimated affinity values for JB93182 and YM022 were significantly higher and that for PD134,308 was significantly lower than those obtained in the mouse cortex when the same radioligand was used. In view of our previous data obtained with L-365,260, the rat cortex data were also interpreted using a two-site model. In this analysis, SR27897 expressed approximately 9 fold, PD134,308 approximately 13 fold and PD140,376 approximately 11 fold selectivity for the G2 site. In contrast, JB93182 expressed approximately 23 fold and YM022 approximately 4 fold selectivity for the G1 site. If the two-site interpretation of the data is valid then, because of its reverse selectivity to L-365,260, JB93182 has been identified as a compound which if radiolabelled could provide a test of this receptor subdivision. (+info)Characterization of the binding of a novel radioligand to CCKB/gastrin receptors in membranes from rat cerebral cortex. (7/1212)
1. We have investigated the binding of a novel radiolabelled CCKB/gastrin receptor ligand, [3H]-JB93182 (5[[[(1S)-[[(3,5-dicarboxyphenyl)amino]carbonyl]-2-phenylethyla mino]-carbonyl]-6-[[(1-adamantylmethyl) amino]carbonyl]-indole), to sites in rat cortex membranes. 2. The [3H]-JB93182 was 97% radiochemically pure as assessed by reverse-phase HPLC (RP-HPLC) and was not degraded by incubation (150 min) with rat cortex membranes. 3. Saturation analysis indicated that [3H]-JB93182 labelled a homogeneous population of receptors in rat cortex membranes (pKD=9.48+/-0.08, Bmax=3.61+/-0.65 pmol g(-1) tissue, nH=0.97+/-0.02, n=5). The pKD was not significantly different when estimated by association-dissociation analysis (pKD=9.73+/-0.11; n=10). 4. In competition studies, the low affinity of the CCKA receptor antagonists, L-364,718; SR27897 and 2-NAP, suggest that, under the assay conditions employed, [3H]-JB93182 (0.3 nM) does not label CCKA receptors in the rat cortex. 5. The affinity estimates obtained for reference CCKB/gastrin receptor antagonists were indistinguishable from one of the affinity values obtained when a two site model was used to interpret [125I]-BH-CCK8S competition curves obtained in the same tissue (Harper et al., 1999). 6. This study provides further evidence for the existence of two CCKB/gastrin sites in rat cortex. [3H]-JB93182 appears to label selectively sites previously designated as gastrin-G1 and therefore it may be a useful compound for the further discrimination and characterization of these putative receptor subtypes. (+info)L-365,260 inhibits in vitro acid secretion by interacting with a PKA pathway. (8/1212)
The aim of this study was to analyse the antisecretory mechanism of L-365,260 in vitro in isolated rabbit gastric glands. We showed that compound L-365,260, described as a non-peptide specific competitive CCK-B receptor antagonist, was able to dose-dependently inhibit [14C]-aminopyrine accumulation induced by histamine (10(-4) M), carbachol (5x10(-5) M), 3-isobutyl-1-methyl-xanthine (IBMX) (5x10(-6) M) and forskolin (5x10(-7) M) with similar IC50 values respectively of 1.1+/-0.6x10(-7) M, 1.9+/-1.2x10(-7) M, 4.2+/-2.0x10(-7) M and 4.0+/-2.8x10(-7) M. We showed that L-365,260 acted beyond receptor activation and production of intracellular second messengers and that it had no action on the H+/K+ -ATPase. We found that L-365,260 inhibited cyclic AMP-induced [14C]-aminopyrine accumulation in digitonin-permeabilized rabbit gastric glands, suggesting that this compound acted, at least in part, as an inhibitor of the cyclic AMP-dependent protein kinase (PKA) pathway. (+info)Phenylurea compounds are a class of chemical compounds that contain a phenyl group (a functional group consisting of a six-membered aromatic ring with a hydrogen atom and a single bond to a carbon atom or other group) linked to a urea moiety. Urea is an organic compound that contains a carbonyl functional group connected to two amine groups.
Phenylurea compounds are commonly used as herbicides, fungicides, and insecticides in agriculture due to their ability to inhibit certain enzymes and disrupt plant growth processes. Some examples of phenylurea compounds include chlorotoluron, diuron, linuron, and monuron.
It is important to note that some phenylurea compounds have been found to be toxic to non-target organisms, including mammals, birds, and fish, and can pose environmental risks if not used properly. Therefore, it is essential to follow the recommended guidelines for their use and disposal to minimize potential health and ecological impacts.
Linuron is a type of pesticide called a selective herbicide, which is used to control weeds in various crops such as corn, soybeans, and vegetables. It works by inhibiting the growth of susceptible plants, causing them to die. Linuron is absorbed by the leaves and roots of the plants and moves throughout the plant to provide long-lasting control of weeds.
It is important to note that linuron can be harmful if swallowed, inhaled, or comes into contact with the skin. It can cause irritation to the eyes, skin, and respiratory tract, and prolonged exposure can lead to more serious health effects. Therefore, it is essential to follow all safety guidelines when using linuron or any other pesticide.
Herbicides are a type of pesticide used to control or kill unwanted plants, also known as weeds. They work by interfering with the growth processes of the plant, such as inhibiting photosynthesis, disrupting cell division, or preventing the plant from producing certain essential proteins.
Herbicides can be classified based on their mode of action, chemical composition, and the timing of their application. Some herbicides are selective, meaning they target specific types of weeds while leaving crops unharmed, while others are non-selective and will kill any plant they come into contact with.
It's important to use herbicides responsibly and according to the manufacturer's instructions, as they can have negative impacts on the environment and human health if not used properly.
Comamonadaceae is a family of gram-negative, aerobic or facultatively anaerobic bacteria that are commonly found in various environments such as soil, water, and the rhizosphere of plants. The name Comamonadaceae comes from the type genus Comamonas. Members of this family are known to be metabolically versatile and can degrade a wide range of organic compounds, including aromatic compounds and polysaccharides. Some species in this family are also known to be opportunistic pathogens in humans, causing infections such as pneumonia, bacteremia, and meningitis.
Methylurea compounds are organic substances that contain the functional group methylurea, which is formed by the reaction between methylamine and carbonyl diurea. These compounds have the general structure O=C(NH)NH-CO-N(CH3)NH2. They can be found in various chemical and pharmaceutical products, including as intermediates in the synthesis of certain drugs and polymers. Methylurea compounds are also used as herbicides and in the treatment of some medical conditions. However, exposure to high levels of methylurea or its derivatives can be harmful and may cause irritation to the skin, eyes, and respiratory tract.
Diuron is a pesticide and herbicide that is used to control weeds in various settings, such as agriculture, landscaping, and forestry. Its chemical name is 3-(3,4-dichlorophenyl)-1,1-dimethylurea. Diuron works by inhibiting photosynthesis in plants, which prevents them from growing and eventually kills them.
While diuron is effective at controlling weeds, it can also have harmful effects on non-target organisms, including aquatic life and pollinators. Additionally, there are concerns about the potential for diuron to contaminate water sources and pose risks to human health. As a result, its use is regulated in many countries, and there are restrictions on how it can be applied and disposed of.
It's worth noting that Diuron is not a medical term or a drug used for treating any medical condition in humans or animals.
Molecular structure, in the context of biochemistry and molecular biology, refers to the arrangement and organization of atoms and chemical bonds within a molecule. It describes the three-dimensional layout of the constituent elements, including their spatial relationships, bond lengths, and angles. Understanding molecular structure is crucial for elucidating the functions and reactivities of biological macromolecules such as proteins, nucleic acids, lipids, and carbohydrates. Various experimental techniques, like X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy (cryo-EM), are employed to determine molecular structures at atomic resolution, providing valuable insights into their biological roles and potential therapeutic targets.
Sulfur compounds refer to chemical substances that contain sulfur atoms. Sulfur can form bonds with many other elements, including carbon, hydrogen, oxygen, and nitrogen, among others. As a result, there is a wide variety of sulfur compounds with different structures and properties. Some common examples of sulfur compounds include hydrogen sulfide (H2S), sulfur dioxide (SO2), and sulfonic acids (R-SO3H).
In the medical field, sulfur compounds have various applications. For instance, some are used as drugs or drug precursors, while others are used in the production of medical devices or as disinfectants. Sulfur-containing amino acids, such as methionine and cysteine, are essential components of proteins and play crucial roles in many biological processes.
However, some sulfur compounds can also be harmful to human health. For example, exposure to high levels of hydrogen sulfide or sulfur dioxide can cause respiratory problems, while certain organosulfur compounds found in crude oil and coal tar have been linked to an increased risk of cancer. Therefore, it is essential to handle and dispose of sulfur compounds properly to minimize potential health hazards.
Volatile Organic Compounds (VOCs) are organic chemicals that have a low boiling point and easily evaporate at room temperature. They can be liquids or solids. VOCs include a variety of chemicals, such as benzene, toluene, xylene, and formaldehyde, which are found in many household products, including paints, paint strippers, and other solvents; cleaning supplies; pesticides; building materials and furnishings; office equipment such as copiers and printers, correction fluids and carbonless copy paper; and glues and adhesives.
VOCs can cause both short- and long-term health effects. Short-term exposure to high levels of VOCs can cause headaches, dizziness, visual disturbances, and memory problems. Long-term exposure can cause damage to the liver, kidneys, and central nervous system. Some VOCs are also suspected or known carcinogens.
It is important to properly use, store, and dispose of products that contain VOCs to minimize exposure. Increasing ventilation by opening windows and doors or using fans can also help reduce exposure to VOCs.
N-Benzoyl-N'-phenylurea
1,3-Diphenylurea
Benzoylurea
Chlortoluron
VEGFR-2 inhibitor
Nicarbazin
Ureas
Cytokinin
Centralite
Pencycuron
DCMU
Dulcin
Quizartinib
Sorafenib: where do we go from here?
N-Benzoyl-N'-phenylurea - Wikipedia
Effects of a bicarbonate-alkaline mineral water on gastric functions and functional dyspepsia: a preclinical and clinical study
1,3-bis{4-[dihydroxy(oxido)-|E5-stibanyl]phenyl}urea | C13H14N2O7Sb2 | CID 225717 - PubChem
Long-lasting cholecystokinin(2) receptor blockade after a single subcutaneous injection of YF476 or YM022. | CureHunter
Publication Detail
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OPUS 4 | Search
MESH TREE NUMBER CHANGES - 2014 MeSH. July 29, 2013
MESH TREE NUMBER CHANGES - 2014 MeSH. July 29, 2013
MESH TREE NUMBER CHANGES - 2014 MeSH. July 29, 2013
MESH TREE NUMBER CHANGES - 2014 MeSH. July 29, 2013
Cppu2
- The synthetic cytokinin forchlorfenuron N-(2-chloro-4-pyridinyl)-N'-phenylurea (CPPU) is widely used, its effect on grape quality is poorly understood. (cgiar.org)
- Metabolomic analyses showed shifts in the abundance of compounds associated with carbohydrate metabolism and TCA cycle in CPPU-treated grapes. (cgiar.org)
Cytokinin1
- Although these compounds do not possess intrinsic cytokinin activity, we have demonstrated their tremendous potential for use in the plant tissue culture industry as well as in agriculture. (rcsb.org)
Inhibitor1
- Inhibitor 5 and the compounds disclosed bind to 3CLpro using a non-covalent mode of action that utilize a His163 H-bond interaction in the S1 subpocket. (bvsalud.org)
Synthetic2
Acetate1
- Moreover, the relative percentage of the linalyl-cation-derived compounds, linalool and linalyl acetate, decreased in most of the regenerated plants. (eurekamag.com)
Herbicides1
- In order to get a comprehensive picture on the behavior in municipal wastewater treatment, the following groups of emerging organic micropollutants, spanning a broad range of applications and physico-chemical properties, were selected as target compounds: pharmaceuticals (beta blockers, psycho-active drugs), UV-filters, vulcanization accelerators (benzothiazoles), biocides (anti-dandruffs, preservatives, disinfectants) and pesticides (phenylurea and triazine herbicides). (hbz-nrw.de)
Organic2
- N-Benzoyl-N′-phenylurea is an organic compound with PhCONHCONHPh formula. (wikipedia.org)
- A wide range of halogenated organic compounds were used as solvents, agricultural chemicals, and insulating liquids. (ispub.com)
Substances1
- Il s'agit d'une source d'informations unique sur les substances chimiques fabriquées et importées en Europe. (europa.eu)
Maize1
- They were tested on four CKX isoforms from maize and Arabidopsis, where the best compounds showed IC50 values in the 10-8 M concentration range. (rcsb.org)
Inhibition1
- Description: In a biochemical assay measuring inhibition of peptide substrate phosphorylation by the test compound in the presence ot recombinant human c-FMS. (guidetomalariapharmacology.org)
Percentage1
- 5μӏ of sample is injected and this operation is repeated using the C6 and C18 columns with percentage change of the compounds of the mobile phase and the flow values are 0.9 ml / min, 1.5 ml / min. (ijpsr.com)
Increases2
- The combinatorial chemistry and high throughput screening increases the solubility of poorly water soluble compounds. (scialert.net)
- We have identified a key substance, compound 19, which not only increases stress resistance and seed yield in Arabidopsis, but also improves the yield of wheat, barley and rapeseed grains under field conditions. (rcsb.org)
Toxic1
- instead it occasionally leads to the formation of metabolic products that are more toxic or persistent than the parent compound 4 . (nature.com)
Structure3
- Structure of N-benzoyl-N′-phenylurea was first determined in 2010. (wikipedia.org)
- Starting from compound 5 (CCF0058981), a structure-based optimization of the P1 subsite was performed against the severe acute respiratory syndrome coronavirus (SARS-CoV-2) main protease (3CLpro). (bvsalud.org)
- Compounds based on benzeneacetamide, that are similar in structure to ACETANILIDES . (nih.gov)
Activity1
- Antioxidant Activity of Some Algerian Medicinal Plants Extracts Containing Phenolic Compounds. (innspub.net)
Herbicides2
- The enzyme, found in members of the Sphingobium genus, initiates the degradation of N,N-dimethyl-phenylurea herbicides by mono-N- demethylation. (expasy.org)
- several bio adsorbents have all been used for trace-level analysis of various targets (e.g., pharmaceuticals, PAHs, pesticides, carbamate, bisphenols, phenols, phthalate acid esters, phenylurea herbicides and hormones,) prior to their identification by chromatographic and spectrometric techniques. (crimsonpublishers.com)
Volatile organic c1
- Similarly, the European Parliament and the Council of the European Union have specified the regulative systems for dangerous particles, volatile organic compounds, and greenhouse gases into indoor or outdoor air" [3]. (crimsonpublishers.com)
Niacinamide1
- A niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. (bvsalud.org)
Phenyl2
- Forchlorfenuron is a phenyl urea compound. (industryherald24.com)
- High-throughput screening (HTS) of Roche's compound collections identified a tetrahydropyrazolopyrazine (THPP) scaffold that was further optimized to increase potency, via modification of the phenyl urea substituent, and increase solubility, exemplified by the inclusion of the morpholino-lactone group. (dalriadatx.com)
Toxicity1
- They have been treated for decades with immunotherapeutic agents like interferon alfa, cytokines and monoclonal antibodies, but both the marginal efficacy and the significant toxicity of these compounds have generally limited the median survival rate of the treated patients to six months 5 . (nature.com)
Mechanism of act2
- Carbanilides, including TCC, enhanced hormone-dependent induction of ER- and AR-dependent gene expression but had little agonist activity, suggesting a new mechanism of action of endocrine-disrupting compounds. (nih.gov)
- In HBV carrier mice, 17i reduced serum levels of HBV DNA and expression of HBcAg in the liver, pointing to capsid assembly inhibition as the main mechanism of action for the compound. (dalriadatx.com)
Orally1
- These compounds are orally active. (mmpc.org)
Organic compound2
- N-Benzoyl-N′-phenylurea is an organic compound with PhCONHCONHPh formula. (wikipedia.org)
- Benzene is an organic compound with the molecular formula C6H6. (ambeed.com)
Drugs1
- Several groups of organic compounds, i.e., new brominated flame retardants, drugs of abuse and their metabolites, disinfection by-products, perfluoroalkyl substances, hormones, pharmaceuticals and siloxanes, are now considered to be emergent organic contaminants based on the risk they pose to human health and entire ecosystems, even at low or trace concentration levels. (crimsonpublishers.com)
Administration1
- The only possible carcinogenic effects from compound administration were in male mice. (nih.gov)
Human2
- Compound 6a , merging the best inhibitory profile against the target kinases, showed anti-proliferative efficacy against the human melanoma cell lines A2058, expressing the BRAF V600D mutation, and WM266-4, expressing BRAF V600E. (nature.com)
- As HBV replication occurs primarily in the liver, the medicinal chemistry team concurrently evaluated many of the compounds prepared in human and mouse liver microsomes to assess clearance. (dalriadatx.com)
Total1
- This graph shows the total number of publications written about "Trityl Compounds" by people in this website by year, and whether "Trityl Compounds" was a major or minor topic of these publications. (uchicago.edu)
Shown1
- Bisphenol A (BPA) is an endocrine disruptor which has been shown to be a harmful compound for living organisms. (nel.edu)
Treatment2
- Disclosed are compounds that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (PCSK9), and methods of using these modulators to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease (CVD), including treatment of hypercholesterolemia. (justia.com)
- The team at the China Innovation Center of Roche recently disclosed this hit-to-lead compound aimed at breaking the "therapeutic ceiling" associated with current hepatitis B virus (HBV) treatment options (current options are pegylated interferons and modified nucleosides/tides). (dalriadatx.com)
Target1
- Further washout experiments in MCF-7 cells looking at the acetylation of HDAC 1/2 target proteins confirmed the slow binding kinetics of the compound. (dalriadatx.com)