The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.
Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The concept concerned with all aspects of providing and distributing health services to a patient population.
A systematic collection of factual data pertaining to health and disease in a human population within a given geographic area.
The state wherein the person is well adjusted.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.
A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
A plant genus of the family Ephedraceae, order Ephedrales, class Gnetopsida, division Gnetophyta.
A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.
An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.
A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.
Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.
The interactions between physician and patient.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Use of plants or herbs to treat diseases or to alleviate pain.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.
Accidental or deliberate use of a medication or street drug in excess of normal dosage.
A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
Delivery of medications through the nasal mucosa.
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (From Biochem Soc Trans 1992 Feb;20(1):122-5)

Sensitivity of [11C]phenylephrine kinetics to monoamine oxidase activity in normal human heart. (1/2866)

Phenylephrine labeled with 11C was developed as a radiotracer for imaging studies of cardiac sympathetic nerves with PET. A structural analog of norepinephrine, (-)-[11C]phenylephrine (PHEN) is transported into cardiac sympathetic nerve varicosities by the neuronal norepinephrine transporter and stored in vesicles. PHEN is also a substrate for monoamine oxidase (MAO). The goal of this study was to assess the importance of neuronal MAO activity on the kinetics of PHEN in the normal human heart. MAO metabolism of PHEN was inhibited at the tracer level by substituting deuterium atoms for the two hydrogen atoms at the alpha-carbon side chain position to yield the MAO-resistant analog D2-PHEN. METHODS: Paired PET studies of PHEN and D2-PHEN were performed in six normal volunteers. Hemodynamic and electrocardiographic responses were monitored. Blood levels of intact radiotracer and radiolabeled metabolites were measured in venous samples taken during the 60 min dynamic PET study. Myocardial retention of the tracers was regionally quantified as a retention index. Tracer efflux between 6 and 50 min after tracer injection was fit to a single exponential process to obtain a washout half-time for all left ventricular regions. RESULTS: Although initial heart uptake of the two tracers was similar, D2-PHEN cleared from the heart 2.6 times more slowly than PHEN (mean half-time 155+/-52 versus 55+/-10 min, respectively; P < 0.01). Correspondingly, heart retention of D2-PHEN at 40-60 min after tracer injection was higher than PHEN (mean retention indices 0.086+/-0.018 versus 0.066+/-0.011 mL blood/ min/mL tissue, respectively; P < 0.003). CONCLUSION: Efflux of radioactivity from normal human heart after uptake of PHEN is primarily due to metabolism of the tracer by neuronal MAO. Related mechanistic studies in the isolated rat heart indicate that vesicular storage of PHEN protects the tracer from rapid metabolism by neuronal MAO, suggesting that MAO metabolism of PHEN leaking from storage vesicles leads to the gradual loss of PHEN from the neurons. Thus, although MAO metabolism influences the rate of clearance of PHEN from the neurons, MAO metabolism is not the rate-determining step in the observed efflux rate under normal conditions. Rather, the rate at which PHEN leaks from storage vesicles is likely to be the rate-limiting step in the observed efflux rate.  (+info)

Influence of vesicular storage and monoamine oxidase activity on [11C]phenylephrine kinetics: studies in isolated rat heart. (2/2866)

[11C]Phenylephrine (PHEN) is a radiolabeled analogue of norepinephrine that is transported into cardiac sympathetic nerve varicosities by the neuronal norepinephrine transporter and taken up into storage vesicles localized within the nerve varicosities by the vesicular monoamine transporter. PHEN is structurally related to two previously developed sympathetic nerve markers: [11C]-meta-hydroxyephedrine and [11C]epinephrine. To better characterize the neuronal handling of PHEN, particularly its sensitivity to neuronal monoamine oxidase (MAO) activity, kinetic studies in an isolated working rat heart system were performed. METHODS: Radiotracer was administered to the isolated working heart as a 10-min constant infusion followed by a 110-min washout period. Two distinctly different approaches were used to assess the sensitivity of the kinetics of PHEN to MAO activity. In the first approach, oxidation of PHEN by MAO was inhibited at the enzymatic level with the MAO inhibitor pargyline. In the second approach, the two hydrogen atoms on the a-carbon of the side chain of PHEN were replaced with deuterium atoms ([11C](-)-alpha-alpha-dideutero-phenylephrine [D2-PHEN]) to inhibit MAO activity at the tracer level. The importance of vesicular uptake on the kinetics of PHEN and D2-PHEN was assessed by inhibiting vesicular monoamine transporter-mediated storage into vesicles with reserpine. RESULTS: Under control conditions, PHEN initially accumulated into the heart at a rate of 0.72+/-0.15 mL/min/g wet. Inhibition of MAO activity with either pargyline or di-deuterium substitution did not significantly alter this rate. However, MAO inhibition did significantly slow the clearance of radioactivity from the heart during the washout phase of the study. Blocking vesicular uptake with reserpine reduced the initial uptake rates of PHEN and D2-PHEN, as well as greatly accelerated the clearance of radioactivity from the heart during washout. CONCLUSION: These studies indicate that PHEN kinetics are sensitive to neuronal MAO activity. Under normal conditions, efficient vesicular storage of PHEN serves to protect the tracer from rapid metabolism by neuronal MAO. However, it is likely that leakage of PHEN from the storage vesicles and subsequent metabolism by MAO lead to an appreciable clearance of radioactivity from the heart.  (+info)

Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey. (3/2866)

We investigated whether uninjured cutaneous C-fiber nociceptors in primates develop abnormal responses after partial denervation of the skin. Partial denervation was induced by tightly ligating spinal nerve L6 that innervates the dorsum of the foot. Using an in vitro skin-nerve preparation, we recorded from uninjured single afferent nerve fibers in the superficial peroneal nerve. Recordings were made from 32 C-fiber nociceptors 2-3 wk after ligation and from 29 C-fiber nociceptors in control animals. Phenylephrine, a selective alpha1-adrenergic agonist, and UK14304 (UK), a selective alpha2-adrenergic agonist, were applied to the receptive field for 5 min in increasing concentrations from 0.1 to 100 microM. Nociceptors from in vitro control experiments were not significantly different from nociceptors recorded by us previously in in vivo experiments. In comparison to in vitro control animals, the afferents found in lesioned animals had 1) a significantly higher incidence of spontaneous activity, 2) a significantly higher incidence of response to phenylephrine, and 3) a higher incidence of response to UK. In lesioned animals, the peak response to phenylephrine was significantly greater than to UK, and the mechanical threshold of phenylephrine-sensitive afferents was significantly lower than for phenylephrine-insensitive afferents. Staining with protein gene product 9.5 revealed an approximately 55% reduction in the number of unmyelinated terminals in the epidermis of the lesioned limb compared with the contralateral limb. Thus uninjured cutaneous C-fiber nociceptors that innervate skin partially denervated by ligation of a spinal nerve acquire two abnormal properties: spontaneous activity and alpha-adrenergic sensitivity. These abnormalities in nociceptor function may contribute to neuropathic pain.  (+info)

Effect of acute and long-term treatment with 17-beta-estradiol on the vasomotor responses in the rat aorta. (4/2866)

1. This study sought to evaluate whether the effects of acute and long-term treatment with 17-beta-estradiol on the vasomotor responses in rat aortic rings are mediated through the same mechanism. 2. Ovariectomized rats were treated daily with either 17-beta-estradiol-3-benzoate (100 microg kg(-1)) or vehicle for 1 week. 3. The effect of long-term 17-beta-estradiol treatment on the responses to cumulative doses of phenylephrine, 5-HT, calcium, potassium and 17-beta-estradiol was determined in aortic rings. In the same rings, the effect of acute exposure to 17-beta-estradiol (5 and 10 microM) on the dose response curves for phenylephrine, 5-HT, calcium, potassium and acetylcholine were estimated. The measurements were made in rings with and without intact endothelium. The tone-related basal release of nitric oxide (NO) was measured in rings with intact endothelium. 4. Long-term 17-beta-estradiol treatment reduced the maximum developed contraction to all contracting agents studied. This effect was abolished in endothelium denuded vessels. Acute 17-beta-estradiol treatment also reduced maximal contraction. This effect, however, was independent of the endothelium. 5. Long-term 17-beta-estradiol treatment significantly increased the ability of the rings to dilate in response to acetylcholine whereas acute exposure to 17-beta-estradiol had no effect. The tone-related release of NO was significantly increased after long-term exposure to 17-beta-estradiol. 6. In conclusion, this study indicate that the acute and long-term effects of 17-beta-estradiol in the rat aorta are mediated through different mechanisms. The long-term effect is mediated through the endothelium most likely by increasing NO release. In contrast, the acute effect of 17-beta-estradiol seems to be through an effect on the vascular smooth muscle cells.  (+info)

Modulation of temperature-induced tone by vasoconstrictor agents. (5/2866)

One of the primary cardiovascular adjustments to hyperthermia is a sympathetically mediated increase in vascular resistance in the viscera. Nonneural factors such as a change in vascular tone or reactivity may also contribute to this response. Therefore, the aim of this study was to determine whether vascular smooth muscle tone is altered during heating to physiologically relevant temperatures >37 degrees C. Gradually increasing bath temperature from 37 degrees C (normothermia) to 43 degrees C (severe hyperthermia) produced graded contractions in vascular ring segments from rat mesenteric arteries and thoracic aortae. In untreated rings these contractions were relatively small, whereas hyperthermia elicited near-maximal increases in tension when rings were constricted with phenylephrine or KCl before heating. In phenylephrine-treated mesenteric arterial rings, the contractile responses to heating were markedly attenuated by the Ca2+ channel antagonists nifedipine and diltiazem. Diltiazem also blocked the contractile responses to heating in thoracic aortic rings. These results demonstrate that hyperthermia has a limited effect on tension generation in rat vascular smooth muscle in the absence of vascular tone. However, in the presence of agonist-induced tone, tension generation during heating is markedly enhanced and dependent on extracellular Ca2+. In conclusion, these data suggest that local regulation of vascular tone can contribute to the hemodynamic adjustments to hyperthermia.  (+info)

Latrunculin-A causes mydriasis and cycloplegia in the cynomolgus monkey. (6/2866)

PURPOSE: To determine the effect of latrunculin (LAT)-A, which binds to G-actin and disassembles actin filaments, on the pupil, accommodation, and isolated ciliary muscle (CM) contraction in monkeys. METHODS: Pupil diameter (vernier calipers) and refraction (coincidence refractometry) were measured every 15 minutes from 0.75 to 3.5 hours after topical LAT-A 42 microg (approximately 10 microM in the anterior chamber [AC]). Refraction was measured every 5 minutes from 0.5 to 1.5 hours after intracameral injection of 10 microl of 50 microM LAT-A (approximately 5 microM in AC), with intramuscular infusion of 1.5 mg/kg pilocarpine HCl (PILO) during the first 15 minutes of measurements. Pupil diameter was measured at 1 and 2 hours, and refraction was measured every 5 minutes from 1 to 2 hours, after intravitreal injection of 20 microl of 1.25 mM LAT-A (approximately 10 microM in vitreous), with intramuscular infusion of 1.5 mg/kg PILO during the first 15 minutes of measurements (all after topical 2.5% phenylephrine), and contractile response of isolated CM strips, obtained <1 hour postmortem and mounted in a perfusion apparatus, to 10 microM PILO +/- LAT-A was measured at various concentrations. RESULTS: Topical LAT-A of 42 microg dilated the pupil without affecting refraction. Intracameral LAT-A of 5 microM inhibited miotic and accommodative responses to intramuscular PILO. Intravitreal LAT-A of 10 microM had no effect on accommodative or miotic responses to intramuscular PILO. LAT-A dose-dependently relaxed the PILO-contracted CM by up to 50% at 3 microM in both the longitudinal and circular vectors. CONCLUSIONS: In monkeys, LAT-A causes mydriasis and cycloplegia, perhaps related to its known ability to disrupt the actin microfilament network and consequently to affect cell contractility and adhesion. Effects of LAT-A on the iris and CM may have significant physiological and clinical implications.  (+info)

Endothelin antagonists block alpha1-adrenergic constriction of coronary arterioles. (7/2866)

We have previously observed that intracoronary administration of the alpha1-adrenergic agonist phenylephrine (PE) over a period of minutes induced both an immediate and long-lasting (2 h) vasoconstriction of epicardial coronary arterioles. Because it is unlikely that alpha1-adrenergic constriction would persist for hours after removal of the agonist, this observation supports the view that another constrictor(s) is released during alpha1-adrenergic activation and induces the prolonged vasoconstriction. Therefore, we hypothesized that the prolonged microvascular constriction after PE is due to the production of endothelin (ET). We focused on ET not only because this peptide produces potent vasoconstriction but also because its vasoconstrictor action is characterized by a long duration. To test this hypothesis, the diameters of coronary arterioles (<222 micrometers) in the beating heart of pentobarbital-anesthetized dogs with stroboscopic intravital microscopy were measured during a 15-min intracoronary infusion of PE (1 microgram. kg-1 . min-1) and at 15-min intervals for a total of 120 min. All experiments were performed in the presence of beta-adrenergic blockade with propranolol. At 120 min, arterioles in the PE group were constricted (-23 +/- 9% change in diameter vs. baseline). Pretreatment with the ET-converting enzyme inhibitor phosphoramidon or the ETA-receptor antagonist FR-139317 prevented the PE-induced constriction at 120 min (-1 +/- 3 and -6 +/- 3%, respectively, P < 0.01 vs. PE). Pretreatment with the selective alpha1-adrenergic antagonist prazosin (Prz) also prevented the sustained constriction (0 +/- 2%, P < 0.01 vs. PE) but Prz given 60 min after PE infusion did not (-13 +/- 3%). In the aggregate, these results show that vasoconstriction of epicardial coronary arterioles via alpha1-adrenergic activation is blocked by an ET antagonist and an inhibitor of its production. From these data, we conclude that alpha1-adrenergic activation promotes the production and/or release of ET, which produces or facilitates microvascular constriction of epicardial canine coronary arterioles.  (+info)

Altered alpha 1-adrenoceptor subtypes mediated cardiac function after treatment of propranolol to rats. (8/2866)

AIM: To study inotropic and chronotropic effects mediated by alpha 1A- and alpha 1B-adrenoceptors after 5-d propranolol (Pro) treatment. METHODS: The positive inotropic and chronotropic effects mediated by alpha 1A and alpha 1B subtypes were determined on isolated left ventricular papillary muscles and right atrium in Pro- and NaCl-treated rats. RESULTS: The basic contractility of papillary muscles induced by phenylephrine (Phe) was 90 +/- 18 mg in Pro-treated rats and 53 +/- 17 mg in control group (P < 0.05). The increment on force of contraction was 20 +/- 12 mg in Pro-pretreated rats and 5 +/- 5 mg in NaCl-treated rats (P < 0.05). After preincubated with chloroethylclonidine, the increment on force of contraction was reduced in Pro-treated rats, but was not much changed in control group. Phe in presence of 5-methylurapidil induced positive inotropic effect with 13 +/- 5 mg in Pro-treated group, but not in NaCl-treated rats. Under the normal and the inhibited cardiac state, the maximal increment in beat rate mediated by alpha 1B showed no difference between the Pro-treated and NaCl-treated rats. CONCLUSION: After chronic treatment of Pro, alpha 1-adrenoceptor-mediated positive inotropic effect in rat heart was improved, which was mainly induced by stimulation of alpha 1B when beta-adrenoceptors were blocked.  (+info)

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J. S. Smith, D. J. Benefiel, P. N. Beaupre, Y. J. Sohn, F. W. Lurz, B. Byrd, A. Bouchard, N. B. Schiller, M. K. Cahalan, M. F. Roizen; EFFECT OF PHENYLEPHRINE ON MYOCARDIAL PERFORMANCE DURING CAROTID ENDARTERECTOMY. Anesthesiology 1984; 61:A56 doi: https://doi.org/10.1097/00000542-198409001-00056. Download citation file:. ...
Phenylephrine or Neo-Synephrine is an α1-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Phenylephrine has recently been marketed as a substitute for pseudoephedrine but there are recent claims that oral phenylephrine may be no more effective as a decongestant than a placebo.
Transient receptor potential (TRP) channels contribute to endothelial cytosolic calcium signaling. Roles for both transient receptor potential C3 (TRPC3) and vallinoid type4 (TRPV4) in agonist-evoked endothelium-dependent vascular relaxation have been proposed. Thus, in this study we have investigated the functional contribution of these channels to endothelium-dependent modulation of phenylephrine- and nerve-evoked increases in tone and to acetylcholine-evoked relaxation in rat mesenteric arteries. Using an immunohistochemical approach, TRPC3 and TRPV4 antibodies showed low level diffuse and punctate labeling in endothelial cells and absence in smooth muscle cells. 1-[4- [(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5- (trifluoromethyl)-1H-pyrazole-4-carboxylic acid (Pyr3), a selective inhibitor of TRPC3 channels enhanced nerve- and phenylephrine-induced increases in tone in endotheliumintact arteries but was without effect on acetylcholine-evoked relaxations. 1-(4-chloro-2-nitrophenyl) sulfonyl
Description: Phenylephrine is a synthetic sympathomimetic amine with selectivity for the alpha-1-adrenergic receptor. Phenylephrine lacks significant inotropic and chronotropic effects. Pharmacologically, it most closely resembles the older drug methoxamine. Phenylephrine is commonly used orally, alone or in combination with other drugs, and intranasally to treat nasal congestion. When administered topically to the eye, it induces mydriasis and, thus, phenylephrine is often used as a diagnostic
TY - JOUR. T1 - Dynamic Analysis of Müllers Muscle Response to Phenylephrine. AU - Ramesh, Sathyadeepak. AU - Mancini, Ronald. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Purpose: To characterize in vivo response of Mullers muscle to phenylephrine about time and diurnal variation. Methods: A nonrandomized trial of adults without (n = 20, 40 eyes) and with ptosis (n = 5, 5 eyes) measured for response of marginal reflex distance-1 (MRD1) to topical phenylephrine (2.5%) every 15 seconds in the morning (6-10 am) and evening (6-10 pm). Mean MRD1 was plotted over time, and morning and evening MRD1 were compared with the Spearman correlation coefficient (r) and paired t test. Results: Regardless of the time of day, subjects with and without ptosis had maximal response to phenylephrine within 2 minutes, with persistence of response at 30 minutes. There was good correlation (r = 0.92), with no statistically significant difference in rate or amount of change of MRD1 between morning and evening time points. ...
Phenylephrine - Get up-to-date information on Phenylephrine side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Phenylephrine
We tested the hypothesis that humoral or neurogenic alpha-adrenergic activation in the coronary circulation would produce heterogeneous vascular reactions. To accomplish this, the epicardial coronary microcirculation was viewed through an intravital microscope using stroboscopic epi-illumination. Microvascular diameters were measured under control conditions during beta-adrenergic blockade (propranolol 1 mg/kg) and beta-adrenergic blockade with pacing; during coronary alpha-adrenergic activation in the presence of beta-adrenergic blockade with three doses of norepinephrine infusion (0.1, 0.5, and 1.0-2.0 micrograms/kg/min) or three frequencies of bilateral stellate nerve stimulation (2, 10, and 20 Hz); and during combined alpha- and beta-adrenergic blockade (phentolamine 2 mg/kg and propranolol 1 mg/kg). Diameters of both arterial and venous vessels were reduced during beta-adrenergic blockade but returned back to baseline with pacing. At the lowest level of norepinephrine infusion or frequency ...
PURPOSE: Hypotension is common after spinal anesthesia for Cesarean delivery. It is associated with nausea, vomiting, and fetal acidosis. Previous research on phenylephrine excluded obese subjects. We compared the incidence of intraoperative nausea and vomiting (IONV) in obese patients who received a prophylactic phenylephrine infusion vs those who received bolus dosing for the treatment of spinal-induced hypotension. METHODS: In this multicentre, double-blinded randomized controlled trial, 160 obese women undergoing elective Cesarean delivery under spinal anesthesia were randomized to receive a prophylactic phenylephrine infusion initiated at 50 μg·min-1 (and titrated according to a predefined algorithm) or 100 μg phenylephrine boluses to treat hypotension ...
Analysis of the endothelial function using Mulvany Myograph showed endothelial dysfunction in wild-type as well as in Nox4-/- mice after 20 weeks on high-fat diet. Access to running wheels during the high-fat diet prevented endothelial dysfunction in wild-type but not in Nox4-/- mice. Mechanistically, exercise led to an increased H2O2 release in the aorta of wild-type mice with increased phosphorylation of eNOS pathway member AKT serine/threonine kinase 1 (AKT1). Both H2O2 release and phosphorylation of AKT1 were diminished in aortas of Nox4-/- mice. Deletion of Nox4 also resulted in lower intracellular calcium release proven by reduced phenylephrine-mediated contraction, whilst potassium-induced contraction was not affected. H2O2 scavenger catalase reduced phenylephrine-induced contraction in wild-type mice. Supplementing H2O2 increased phenylephrine-induced contraction in Nox4-/- mice.Exercise induced peroxisome proliferative activated receptor gamma, coactivator 1 alpha (Ppargc1a), as key ...
Phenylephrine,(alphaR)-3-Hydroxy-alpha-[(methylamino)methyl]benzenemethanol,(-)-m-hydroxy-alpha-[(methylamino)methyl]benzyl alcohol,l-1-(m-hydroxyphenyl)-2-methylaminoethanol,l-alpha-hydroxy-beta-methylamino-3-hydroxy-1-ethylbenzene,m-methylaminoethanolphenol,metaoxedrin,Hydrochloride,Phenylephrine Hydrochloride,Ak-Dilate,Ak-Nefrin,Alconefrin,Incostop,Mydfrin,Neo-Synephrine,Nostril,Prefrin,Rhinall
After this repeated doses at steady state, equivalent plasma concentrations are maintained when a Family wellness hemorrhoidal is likely taken every 12 hours as women compared to phenylephrine hbr every 6 hours. Total R - tanna action time also noted improved with phenylephrine, but only shows by 29 minutes. phenylephrine and this possibly of other low potency antipsychotics may therefore reverse the pressor effec
We are engaged in offering a wide scope of PARACETAMOL PHENYLEPHRINE CPM . As per the industry medical industry guidelines, the PARACETAMOL PHENYLEPHRINE CPM are processed and formulated by consuming finest grade chemical compounds and contemporary processing techniques at the vendors highly-advanced labs. PARACETAMOL PHENYLEPHRINE CPM. offered by us are broadly recommended by our customers due to its features like accurate consumption, long shelf life & no side effects .. ...
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TY - JOUR. T1 - Cooling and α1- and α2-adrenergic responses in cutaneous veins. T2 - Role of receptor reserve. AU - Flavahan, Nicholas. AU - Lindblad, L. E.. AU - Verbeuren, T. J.. PY - 1985. Y1 - 1985. N2 - Experiments were designed to determine the effects of cooling on α1- and α2-adrenergic responses in isolated canine cutaneous veins. Rings of saphenous veins were suspended for isometric tension recording in physiological salt solution. Cooling (from 37 to 24°C) augmented contractions to norepinephrine under control conditions and after α1-adrenergic blockade (prazosin) but not following α2-adrenergic blockade (rauwolscine). Cooling augmented contractions evoked by the α2-adrenergic agonists B-HT 920 and UK 14304 but did not affect responses to the full α1-adrenergic agonist phenylephrine. These experiments suggest that cooling augments α2-adrenergic responsiveness without affecting α1-adrenergic responsiveness. However, the contractions evoked by the partial α1-adrenergic ...
A new method, based on computer-assisted kinetic analysis of 45Ca efflux data, was used to measure calcium contents and fluxes for extracellular and intracellular compartments in intact segments of rabbit aorta. After a 1-hour loading period, efflux data were collected for 8 hours using a flow-through tissue chamber. These long-term effluxes were necessary because information on intracellular calcium metabolism was concentrated in the slow components of the efflux curves while earlier components appeared to be dominated by washout of extracellular calcium. Intracellular compartments were identified as those whose calcium contents were altered by 10 microM phenylephrine. This method complements previous approaches by providing simultaneous estimates of compartmental calcium contents and fluxes without requiring the assumption of isotopic equilibrium and without recourse to standard wash techniques for removal of extracellular calcium. In normal, calcium-containing, bicarbonate-buffered ...
1,1-dimethylethyl -4-hydroxyphenyl -3- 3- N-methyl-N- 2 Ž ethyl amino propyl -1,3-thiazolidin-4-one hydrogen fumarate Ž CP-060S , a synthesized cardioprotective agent, were examined. In the rat aortic rings, the contractile responses to cumulative application of angiotensin II, Arg -vasopressin Ž were inhibited by CP-060S in a concentration-dependent manner. The Ca2q-induced contractions in the presence of vasopressin orprostaglandin F were also inhibited by CP-060S in a concentration-dependent manner. The inhibitory effect of 10y5 M CP-060S on phenylephrine-induced contraction was as potent as that of 10y6 M nifedipine, and the combined addition of 10y6 M nifedipine and10y5 M CP-060S showed the effect similar to that of 10y5 M CP-060S alone. In rat aorta loaded with a Ca2q indicator, fura-PE3, 10y5 M CP-060S completely inhibited the high K -induced increase in cytosolic Ca CP-060S only partially inhibited the increase in Ca and contraction due to phenylephrine or prostaglandin F M CP-060S ...
This study was designed to determine whether the relaxant effect of apigenin was endothelium dependent and to examine the possible antiproliferative effect of apigenin. Apigenin relaxed the phenylephrine-precontracted endothelium-intact aortic rings with IC50 value of 3.7+/-0.5 muM and removal of a functional endothelium significantly attenuated this relaxation (IC50 = 8.2+/-0.9 muM). However, apigenin did not affect the 0.1 muM phorbol 12,13-dibutyrate-induced contraction (IC50 = 34.6 +/- 1.2 muM) within the concentration range that relaxed the phenylephrine-contracted arteries, suggesting that apigenin did not influence protein kinase C-mediated contractile mechanisms in rat aorta. Pretreatment of apigenin significantly potentiated the relaxant effect of acetylcholine on phenylephrine-induced contraction. Pretreatment with N-G-nitro-L-arginine methyl ester (L-NAME) or methylene blue reduced the relaxant effect of apigenin. Apigenin (10 muM) increased the guanosine 3′,5′-cyclic ...
Nicotinic acid, known as vitamin B3, is an effective lipid lowering drug and intense cutaneous vasodilator. This study reports the effect of 2-(1-adamantylthio)nicotinic acid (6) and its amide 7 and nitrile analog 8 on phenylephrine-induced contraction of rat thoracic aorta as well as antioxidative activity. It was found that the tested thionicotinic acid analogs 6-8 exerted maximal vasorelaxation in a dose-dependent manner, but their effects were less than acetylcholine (ACh)-induced nitric oxide (NO) vasorelaxation. The vasorelaxations were reduced, apparently, in both NG-nitro-L-arginine methyl ester (L-NAME) and indomethacin (INDO). Synergistic effects were observed in the presence of L-NAME plus INDO, leading to loss of vasorelaxation of both the ACh and the tested nicotinic acids. Complete loss of the vasorelaxation was noted under removal of endothelial cells. This infers that the vasorelaxations are mediated partially by endothelium-induced NO and prostacyclin. The thionicotinic acid analogs all
Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose). Phenylephrine is used to treat nasal and sinus congestion, or congestion of the tubes that drain fluid from your inner ears, called the eustachian (yoo-STAY-shun) tubes...
Physician reviewed phenylephrine ophthalmic patient information - includes phenylephrine ophthalmic description, dosage and directions.
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Irvine, NA, Lillycrop, KA, Fielding, B, Torrens, C, Hanson, MA and Burdge, GC (2015) Polyunsaturated fatty acid biosynthesis is involved in phenylephrine-mediated calcium release in vascular smooth muscle cells. ...
Formula: C9H13NO2MW: 167. 21Salt: HClCAS: 61-76-7MDL NUMBER: MFCD00063028IUPAC: 1-(3-hydroxyphenyl)-2-(methylamino)ethan-1-olSmiles: c1cc(cc(c1)O)C(CNC)OL(-)-Phenylephrine hydrochloride 99%THERAPEUTIC CATEGORY: Phenylephrine or neosynephrine is an ?...
In the anesthetized cat phenylephrine in doses of 10−8, 3 × 10−8 and 10−7 moles/kg caused an increase of dp/dtmax. of the left ventricle without altering the heart rate. This cardiostimulating effect...
Phenylephrine is a selective ?1-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood...
Phenylephrine found in: Nurofen Cold & Flu PE Tablets 24 - Expiry 12/20, Robitussin Chesty Cough & Nasal Congestion PE 200ml - Quantity Restriction (1) Applies, …pain-relieving power of ibuprofen with the..
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Chemical Name: 4-[trans-4-(4-chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride ...
Easy to read patient leaflet for Phenylephrine Eye Drops 10%. Includes indications, proper use, special instructions, precautions, and possible side effects.
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If your nose and sinuses are stuffed up, a decongestant may help. You can use it alone or combine it with an antihistamine. Remember, though, it can increase your heart rate and may cause anxiety or make it hard to fall asleep. If you have a runny nose or sneezing, try an antihistamine.. ...
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites ...
Do not take more than 4 doses in 24 hours. If your symptoms do not go away talk to your doctor or pharmacist. Do not take for more than 7 days unless your doctor tells you to. Do not take more than the amount recommended on the label of the packaging of the medicine you have purchased ...
Save your money-OTC preparations containing phenylephrine don't work well. Let's take a look at some research regarding phenylephrine.
This MassBank Record with Accession KO001646 contains the MS2 mass spectrum of (R)-(-)-Phenylephrine with the InChIKey SONNWYBIRXJNDC-VIFPVBQESA-N.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites ...
You have followed a link to a page that does not exist yet. To create the page, start typing in the box below (see the help page for more info). If you are here by mistake, click your browsers back button. ...
article{APS10101, author = {Jun-zhou Xin and Ji-min Wu and Guo-min Hu and Hui-jun Gu and Ye-nan Feng and Shuai-xing Wang and Wen-wen Cong and Ming-zhe Li and Wen-li Xu and Yao Song and Han Xiao and You-yi Zhang and Li Wang}, title = {α 1 -AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation}, journal = {Acta Pharmacologica Sinica}, volume = {41}, number = {3}, year = {2020}, keywords = {}, abstract = {Acute sympathetic stress causes excessive secretion of catecholamines and induces cardiac injuries, which are mainly mediated by β-adrenergic receptors (β-ARs). However, α1-adrenergic receptors (α1-ARs) are also expressed in the heart and are activated upon acute sympathetic stress. In the present study, we investigated whether α1-AR activation induced cardiac inflammation and the underlying mechanisms. Male C57BL/6 mice were injected with a single dose of α1-AR agonist phenylephrine (PE, 5 or 10 mg/kg, s.c.) with or without pretreatment with α-AR ...
Acetylcholine, Animal, Animal Model, Atherosclerosis, Cardiovascular Disease, Depression, Disease, Endothelium, Mice, Patients, Phenylephrine, Procedure, Risk, Risk Factor, Vasoconstriction, Vasorelaxation
Sudafed PE is a popular over the counter decongestant used to treat cold and flu symptoms. The active ingredient in Sudafed PE is Phenylephrine.
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Phenylephrine test is one of the main factors determining the possibility of performing superior tarsal muscle resection. However, the influence of various factors on its result remains unexplored.Aim. To evaluate the effect of patient age, degree of ptosis, and levator muscle function on the result of the phenylephrine test.Patients and methods. 45 patients were examined (64 eyelids). The following examinations were performed for all patients: assessment of the degree of ptosis, levator muscle function and the phenylephrine test.Results. Age and the degree of ptosis do not affect the results of the phenylephrine test. Reduced levator muscle function leads to a decrease of the phenylephrine test results.Conclusion. The phenylephrine test remains an important criteria for patient selection for the planning superior tarsal muscle resection. Levator muscle function does affect the phenylephrine test result.
Some otolaryngologists administer topical phenylephrine for bleeding control in adenoidectomy surgery. Absorption of this drug from surgical site can lead to increase in blood pressure due to vasoconstriction and then bradycardia related to baroreceptore reflex. Our case was an intraoperative arrest of a 9-yrs-old girl related to administration of topical phenylephrine during adenoidectomy however, bradycardia is a rare complication of topical phenylephrine in ENT surgeries probably due to preoperative administration of atropine or glycopirolate. Due to severe complications have been ever seen, avoidance of topical administration of phenylephrine or other vasoconstrictors with undetermined doses is reasonable.
Author: Allen Loyd V Jr, Year: 2013, Abstract: A formulation for preparing Phenylephrine Hydrochloride 10-mg/mL Injection. Includes ingredients, method of preparation, discussion, and references for the compounding pharmacist.
The FDA requires all potential medication risks for BC SINUS CONGESTION AND PAIN (acetaminophen, chlorpheniramine maleate, phenylephrine hydrochloride powder) be disclosed to consumers, no matter how rare. Here are the warnings and precautions for BC Sinus Congestion and Pain.
Indications for VAZCULEP (phenylephrine hydrochloride injection) refers to the medical reasons for why Vazculep is used and recommended as a treatment.
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Phenylephrine hydrochloride | C9H14ClNO2 | CID 5284443 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Sudafed Blocked Nose Capsules with Phenylephrine hydrochloride effectively clear stuffy noses associated with colds and hay fever, resulting in a clear head.
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Some otolaryngologists administer topical phenylephrine for bleeding control in adenoidectomy surgery. Absorption of this drug from surgical site can lead ...
In contrast to the lack of adverse neonatal effect with phenylephrine, many investigators have reported lower umbilical p H values after prophylactic maternal ephedrine administration. 7,10,12,15-17 This was most evident when large ephedrine doses (≥ 50 mg administered intramuscularly or 3-4 mg/min administered intravenously) were used 12,15 and when no crystalloid preload was administered. 12 Stepwise regression in our study confirmed a significant negative correlation between umbilical arterial p H and total ephedrine dose. LaPorta et al. 23 showed that umbilical arterial p H was negatively correlated with neonatal noradrenaline concentrations, which were much more likely to be high after ephedrine than after phenylephrine administration. They also demonstrated that high neonatal noradrenaline concentrations were related to direct fetal secretion likely induced by ephedrine transferred from the mother to the fetus. 16 Therefore, it is possible that we might not have observed a better ...
The Global and Chinese Phenylephrine Hcl Industry, 2011-2021 Market Research Report is a professional and in-depth study on the current state of the global Phenylephrine Hcl industry with a focus on the Chinese market. The report provides key statistics on the market status of the Phenylephrine Hcl manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. Then, the report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 2011-2016 market shares for each company. Through the statistical analysis, the report depicts the global and Chinese total market of Phenylephrine Hcl industry including capacity, production, production value, cost/profit, supply/demand and Chinese ...
Removal of endothelial cells on rings of rat aorta increased the sensitivity to the selective alpha-1 adrenoceptor agonist phenylephrine, to the nonselective alpha adrenoceptor agonist norepinephrine and to the selective alpha-2 adrenoceptor agonist clonidine. In the case of the first two, which are strong agonists for the alpha-1 adrenoceptor-mediating contraction, removal of endothelium increased sensitivity 4- and 6-fold at the EC30 level, but produced little or no increase in maximum. In the case of clonidine, a partial agonist for the alpha-1 adrenoceptor, which gave only about 15% of the maximum given by phenylephrine on endothelium-containing rings, removal of the endothelium not only shifted the curve to the left but also increased the maximum to about 50% of that given by phenylephrine. The depression of sensitivity to these agonists in rings with endothelium appeared to be due to the vasodepressor action of endothelium-derived relaxing factor (EDRF), as hemoglobin, a specific blocking ...
The evidence for the efficacy of Pd - hist d drops and is derived from studies department of Chlorpheniramine and phenylephrine hydrochloride in overheating the published literature. Results from the study showed that mistrusted the 1064 mg dose studies of Ny - tannic achieved therapeutically relevant plasma concentrations of anorexigen drug myself with a pk profile along that supp
Each caplet of Hemorrhoidal suppositories has 250 mg bid of phenylephrine. The Mucinex multi - action congestion & cold caplets brand managers of phenylephrine should imports be taken with food riots or within 1 hour after eating a meal. I had knelt the choice to go inward with the phenylephrine but after some extended research decided on dronabinol and been on
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Lemsip max all day cold & flu tablets contain two active ingredients, ibuprofen (200mg) and phenylephrine hydrochloride (5mg).
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Methods. Left ventricular hypertrophy was induced in Wistar rats by subcutaneous administration of L-thyroxine for two weeks (THYR), n=17. Animals treated with normal saline served as controls, (NORM), n=20. The thoracic aorta was dissected and cut into rings that were suspended in an isolated organ bath with Krebs-Henseleit buffer. Maximal tension, Tmax, in g was measured in response to KCl and PE at the highest concentration in rings with endothelium (+E) and without endothelium (-E) in both groups. Relaxation response (Relax %) to acetylcholine administration was expressed as % of the maximal tension induced by phenylephrine ...
and alpha1adrenergic agonists are common ingredients in over-the-counter (OTC) cough and cold preparations. Phenylephrine is also available as nasal drops. Following overdose in children, these agents have the potential to cause serious toxicity incl
Phenylephrine nasal decongestant drug molecule. Atoms are represented as spheres with conventional colour coding: hydrogen (white), carbon (grey), oxygen (red), nitrogen (blue). - Stock Image F011/3883
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This includes oxymetazoline (e.g., Afrin), phenylephrine (e.g., Neo-Synephrine), naphazoline (e.g., Privine), and l- ...
Decongestants like ephedrine and phenylephrine. These medications tighten the bladder neck muscles and prevent semen from going ...
α1 selective: phenylephrine, methoxamine, midodrine, oxymetazoline. α2 selective: α-methyldopa, clonidine, brimonidine. β1 ...
Stimulants phenylephrine and pseudoephedrine aren't banned. The most common abused stimulant by athletes is amphetamine. ...
Common decongestants include pseudoephedrine and phenylephrine. Pseudoephedrine is an alpha-adrenergic receptor agonist that ...
Vasopressors used include phenylephrine, dopamine, or norepinephrine. Mean arterial blood pressure is measured and kept at 85 ...
The effectiveness of phenylephrine by mouth as a nasal decongestant is questionable. Gee's Linctus is a cough medicine which ... Examples are ephedrine, phenylephrine, pseudoephedrine, and oxymetazoline. Fever or pain medication. Examples are paracetamol ( ...
Other examples include phenylephrine, isoproterenol, and dobutamine. Stimulation of the D1 receptor by dopaminergic agonists ...
Adrenergic agonists, such as phenylephrine and cyclomydril. Adrenergic agonists may be used if strong mydriasis is needed in ... the role of combined therapy using phenylephrine and ketorolac". Patient Preference and Adherence. 10: 1795-1801. doi:10.2147/ ...
... phenylephrine, and salicylamide as Flukit; with dextromethorphan as Axcel Dextrozine and Hosedyl DM; with dextromethorphan and ...
m-Tyramine Phenylephrine Metaraminol Ciclafrine Hengstmann, J. H.; Konen, W; Konen, C; Eichelbaum, M; Dengler, H. J. (1974). " ...
Phenylephrine Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 615-. ISBN 978-0 ...
They include antihypertensives to treat high blood pressure; ephedrine or phenylephrine to treat low blood pressure; salbutamol ... cardiac output monitoring in parturients undergoing cesarean delivery with spinal anesthesia and prophylactic phenylephrine ...
Hatton RC, Winterstein AG, McKelvey RP, Shuster J, Hendeles L (2007). "Efficacy and safety of oral phenylephrine: systematic ... Eccles, R (2007). "Substitution of phenylephrine for pseudoephedrine as a nasal decongeststant. An illogical way to control ... Theraflu (made by Novartis) - previously contained pseudoephedrine, now contains phenylephrine. Unifed (made by United ... Amphetamine Carbinoxamine/pseudoephedrine Ephedrine Methamphetamine N-Methylpseudoephedrine Phenylephrine Phenylpropanolamine ...
"Cocaine and phenylephrine eye drop test for Parkinson disease". JAMA. Journal of the American Medical Association. 293 (8): 932 ... researchers proposed the use of cocaine in conjunction with phenylephrine administered in the form of an eye drop as a ... the anesthetic is combined with a vasoconstrictor such as phenylephrine or epinephrine. Some otolaryngology (ENT) specialists ...
Ephedrine and phenylephrine, as amine hydrochlorides, are used as decongestants. Amphetamine, methamphetamine, and ...
Oct 2007). "Phenylephrine-induced microvascular occlusion syndrome in a patient with a heterozygous factor V Leiden mutation". ... It has been suggested that phenylephrine may be a cause. Jean L. Bolognia; Joseph L. Jorizzo; Ronald P. Rapini (27 August 2003 ...
"Α1A-Adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries". British Journal of Pharmacology. 150 (1): ...
It is no longer marketed.[why?]. Sertraline Phenylephrine Synephrine phentolamine Pazdernik TL, Kerecsen L (2007) [2003]. "5". ...
Common vasopressors used in shock include: norepinephrine, phenylephrine, dopamine, dobutamine. There is no evidence of ...
Atalik KE, Sahin AS, Doğan N (April 2000). "Interactions between phenylephrine, clonidine and xylazine in rat and rabbit aortas ... Methoxamine Midodrine Metaraminol Phenylephrine Amidephrine α2 agonist: inhibits adenylyl cyclase activity, reduces brainstem ... "The alpha 1-agonist phenylephrine inhibits voltage-gated Ca2(+)-channels in vascular smooth muscle cells of rabbit ear artery ...
... knockout mice exhibited blunted MAP response to phenylephrine administration. There is a large collection of in ... Matrix metalloproteinase-2 proteolysis of calponin 1 resulted in vascular hypocontractility to phenylephrine. Vas deferens ...
As a pharmaceutical, m-synephrine (phenylephrine) is still used as a sympathomimetic (i.e. for its hypertensive and ... Although there are chemical and pharmacological similarities between synephrine and phenylephrine, they are nevertheless ... while phenylephrine has also been called m-Sympatol. The synephrine with which this article deals is sometimes referred to as p ... or with phenylephrine, often with the implication that the perceived similarities in structure should result in similarities in ...
Phenylephrine and Phenylpropanolamine as active ingredients. Bang Pa-in Palace, the former Summer Palace of Thai kings. Bandar ...
Other causes are side effects of topical decongestants such as oxymetazoline and phenylephrine. Both of these medications ...
Görnemann T, Villalón CM, Centurión D, Pertz HH (June 2009). "Phenylephrine contracts porcine pulmonary veins via alpha(1B)-, ...
Side effects of phenylephrine may include: high blood pressure, slow heart rate, and arrhythmia. If this medication is used, it ... If this is not sufficient, the corpus cavernosum may be irrigated with cold, normal saline or injected with phenylephrine. ... If aspiration is not sufficient, a small dose of phenylephrine may be injected into the corpus cavernosum. ...
Taylor JM, Rovin JD, Parsons JT (June 2000). "A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ... Treatment of cardiomyocytes with the hypertrophic agonist, phenylephrine stimulated a rapid increase in tyrosine ...
It is an oxazolidine prodrug of phenylephrine, and hence, an α1-adrenergic receptor agonist.[1] Ganellin CR, Triggle DJ (21 ...
Zumpft CW (January 1975). "Double-blind comparison of metizoline hydrochloride (Ellsyl) and phenylephrine in allergic and ...
... has role vasoconstrictor agent (CHEBI:50514) phenylephrine (CHEBI:8093) is a phenols (CHEBI:33853) ... phenylephrine (CHEBI:8093) has role α-adrenergic agonist (CHEBI:35569) phenylephrine (CHEBI:8093) has role cardiotonic drug ( ... phenylephrine (CHEBI:8093) has role mydriatic agent (CHEBI:50513) phenylephrine (CHEBI:8093) has role nasal decongestant (CHEBI ... phenylephrine (CHEBI:8093) is a secondary amino compound (CHEBI:50995) phenylephrine (CHEBI:8093) is conjugate base of ...
Phenylephrine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class ... Before taking phenylephrine,. *tell your doctor and pharmacist if you are allergic to phenylephrine, any other medications, or ... Poly-Tussin EX® (containing Dihydrocodeine, Guaifenesin, Phenylephrine)§. *Prolex PD® (containing Guaifenesin, Phenylephrine)§ ...
Phenylephrine eye drops are applied to the eye after a topical anesthetic is applied. Phenylephrine has been used as an ... Phenylephrine is not suggested for use in patients with hypertension. The primary side effect of phenylephrine is high blood ... Phenylephrine can be used topically to prevent symptoms of hemorrhoids. Phenylephrine causes the constriction of vascular ... Phenylephrine hydrochloride at 0.25% is used as a vasoconstrictor in some suppository formulations. Recently, Phenylephrine has ...
Find out what health conditions may be a health risk when taken with Chlorcyclizine-Phenylephrine Oral ... WebMD provides common contraindications for Chlorcyclizine-Phenylephrine Oral. ... Chlorcyclizine-Phenylephrine Tablet, Chewable. contraindications. Who should not take Chlorcyclizine-Phenylephrine Tablet, ...
Find out what health conditions may be a health risk when taken with Promethazine-Phenylephrine Oral ... WebMD provides common contraindications for Promethazine-Phenylephrine Oral. ... Drugs & MedicationsPromethazine-Phenylephrine. Who should not take Promethazine-Phenylephrine?. The following conditions are ...
... are single-use preservative-free eye drops that contain the active ingredient phenylephrine ... Minims phenylephrine hydrochloride. Minims phenylephrine hydrochloride are single-use preservative-free eye drops that contain ... Minims phenylephrine hydrochloride are single-use preservative-free eye drops that contain the active ingredient phenylephrine ... Phenylephrine works by acting on alpha receptors on the muscle in the eye that dilates the pupil. This causes this muscle to ...
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Phenylephrine Nasal Spray: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before using phenylephrine nasal spray,. *tell your doctor and pharmacist if you are allergic to phenylephrine, any other ... Phenylephrine nasal spray will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine ... Use phenylephrine nasal spray exactly as directed. Do not use more or less of it or use it more often than prescribed by your ...
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Ask questions and get answers about Phenylephrine. Our support group helps people share their own experience. 10 questions, 17 ... Phenylephrine Patient Information at Drugs.com. *Phenylephrine Information for Consumers. *Phenylephrine Information for ... Phenylephrine vs Pseudoephedrine - Whats the difference between them?. Updated 27 Aug 2019 • 1 answer FAQ by Drugs.com ... Ive been using phenylephrine 0.5% for nasal congestion for more than 5 years daily, is that bad?. Updated 7 Nov 2011 • 1 ...
... phenylephrine (Sudafed PE Non-Drying Sinus Caplets) drug side effects, drug interactions, warnings and precautions, and ... guaifenesin and phenylephrine. *What is guaifenesin, phenylephrine, and how does it work (mechanism of action)? ... Which drugs or supplements interact with guaifenesin, phenylephrine?. *Is guaifenesin, phenylephrine safe to take if Im ... Which drugs or supplements interact with guaifenesin, phenylephrine?. *Is guaifenesin, phenylephrine safe to take if Im ...
Information about this phenylephrine-ophthalmic-route. Pregnancy Category. Explanation. All Trimesters. C. Animal studies have ... Ophthalmic phenylephrine in strengths of 2.5 and 10% is used to dilate (enlarge) the pupil. It is used before eye examinations ... Repeated use of 2.5 or 10% phenylephrine may increase the chance of problems during treatment with this medicine. In addition, ... Children may be especially sensitive to the effects of phenylephrine. This may increase the chance of side effects during ...
Phenylephrine is also available as nasal drops. Following overdose in children, these agents have the potential to cause ... Phenylephrine and related decongestants: Pediatric poisoning. Author. Shan Yin, MD, MPH. Shan Yin, MD, MPH ... Pediatric exposures to phenylephrine and related decongestants primarily occur in one of two ways:. ●Exploratory ingestion of ... Phenylephrine and alpha1 adrenergic agonists are common ingredients in over-the-counter (OTC) cough and cold preparations. ...
PHENYLEPHRINE (sye kloe PEN toe late; fen il EF rin) is used in the eye to dilate your pupils. ... Cyclopentolate; Phenylephrine eye solution. What is this medicine?. CYCLOPENTOLATE; PHENYLEPHRINE (sye kloe PEN toe late; fen ... an unusual or allergic reaction to cyclopentolate, phenylephrine, or other medications, foods, dyes or preservatives ...
PHENYLEPHRINE (fen il EF rin) is a decongestant. It is used to relieve a stuffy nose from allergies, colds, or sinus problems. ... Phenylephrine oral dissolving tablet. What is this medicine?. PHENYLEPHRINE (fen il EF rin) is a decongestant. It is used to ... Dextromethorphan; Guaifenesin; Phenylephrine oral capsules or tablets. *Dextromethorphan; Guaifenesin; Phenylephrine oral drops ... Dextromethorphan; Guaifenesin; Phenylephrine oral suspension. *Dextromethorphan; Guaifenesin; Phenylephrine oral syrup and ...
... , Intravenous Neo-Synephrine, Phenylephrine, Neo-Synephrine. ... Intravenous Phenylephrine. Intravenous Phenylephrine Aka: Intravenous Phenylephrine, Intravenous Neo-Synephrine, Phenylephrine ... These images are a random sampling from a Bing search on the term "Intravenous Phenylephrine." Click on the image (or right ... Push Dose Pressor (Bolus Phenylephrine). *Vasopressor without direct inotropic (contractility) or chronotropic (Heart Rate) ...
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Dilated blood vessels can cause nasal congestion (stuffy nose). Phenylephrine is used to treat nasal and sinus congestion, or ... Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. ... What is the most important information I should know about phenylephrine?. Do not use phenylephrine if you have used an MAO ... What should I discuss with my healthcare provider before taking phenylephrine?. Do not use phenylephrine if you have used an ...
Phenylephrine injection is used to treat hypotension (low blood pressure) that may occur during surgery. ... Appropriate studies have not been performed on the relationship of age to the effects of phenylephrine injection in the ... which may require caution and an adjustment in the dose for patients receiving phenylephrine injection. ... studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of phenylephrine ...
About Phenylephrine Hydrochloride Ophthalmic Solution Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5 percent and 10 ... Phenylephrine Hydrochloride Ophthalmic Solution Important Safety Information Phenylephrine Hydrochloride Ophthalmic Solution, ... Phenylephrine possesses predominantly alpha-adrenergic effects. In the eye, phenylephrine acts locally as a potent ... Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5 percent should be used in these patients. Its for topical ophthalmic ...
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Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal ... It is not known whether chlorpheniramine and phenylephrine will harm an unborn baby. Do not use this medicine without your ... What is the most important information I should know about chlorpheniramine and phenylephrine?. Do not use this medicine if you ... What are the possible side effects of chlorpheniramine and phenylephrine?. Get emergency medical help if you have signs of an ...
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Effectiveness of Intracameral Phenylephrine in Achieving Mydriasis and Reducing Complications During Phacoemulsification: A ... Increase in esodeviation under cycloplegia with 0.5% tropicamide and 0.5% phenylephrine mixed eye drops in patients with ... A Random-allocation Graded Dose-Response Study of Norepinephrine and Phenylephrine for Treating Hypotension during Spinal ... ED50 of intrathecal ropivacaine for cesarean section under prophylactic infusion of phenylephrine: A consort study. ...
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Ibuprofen and Phenylephrine - Last updated on May 8, 2021. All rights owned and reserved by Memorial Sloan Kettering Cancer ...
Phenylephrine relieves a blocked nose by causing the blood vessels in the linings of the nasal passages and sinuses to contract ... Phenylephrine has blood vessel constricting effects that could restrict blood supply to the placenta, or cause problems for ... Its not known if phenylephrine passes into breast milk, or its effect on a nursing infant. When taken by mouth, decongestants ... This is because the combination of phenylephrine with these medicines could cause a dangerous increase in blood pressure ( ...
This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.. ...
  • According to IMS Health, sales of Phenylephrine Ophthalmic Solution, USP, 2.5% and 10% were $24 million for the twelve months ended January 31, 2015. (cnbc.com)
  • Akorn's Phenylephrine Hydrochloride Ophthalmic Solution, USP, is an alpha-1 adrenergic receptor agonist indicated to dilate the pupil. (cnbc.com)
  • Akorn's Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5%, available in 2 mL and 15 mL fill sizes and Phenylephrine Hydrochloride Ophthalmic Solution, USP 10%, available as a 5 mL fill size, is shelf-stable and therefore does not require refrigeration, which is an advantage over the competitor's refrigerated product. (cnbc.com)
  • Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5 percent and 10 percent is an alpha-1 adrenergic receptor agonist used for dilation of the pupil due to its vasoconstrictor and mydriatic action. (prnewswire.com)
  • Phenylephrine Hydrochloride Ophthalmic Solution, USP 10 percent is contraindicated in patients with hypertension or thyrotoxicosis, as well as in pediatric patients under the age of one due to the increased risk of systemic toxicity. (prnewswire.com)
  • Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5 percent should be used in these patients. (prnewswire.com)
  • Paragon BioTeck, Inc., a privately held biopharmaceutical company specializing in the development of ophthalmic pharmaceuticals and therapies, today announced that the U.S. Food and Drug Administration has approved its New Drug Application (NDA) for Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5% and 10%, to dilate the pupil. (prweb.com)
  • Phenylephrine Hydrochloride Ophthalmic Solution has been marketed without FDA approval for decades, and during that time has been administered to millions of patients. (prweb.com)
  • Phenylephrine ophthalmic solution is a prescription medication used to dilate (widen) the pupils prior to examinations or surgical procedures of the eye. (medicineshoppe.com)
  • Two studies published in 2009 examined the effects of phenylephrine on symptoms of allergic rhinitis by exposing people to pollen in a controlled, indoor environment. (wikipedia.org)
  • Neither study was able to distinguish between the effects of phenylephrine or a placebo. (wikipedia.org)
  • A subsequent meta-analysis by the same researchers concluded that there is insufficient evidence for its effectiveness, though another meta-analysis published shortly thereafter by researchers from GlaxoSmithKline found the standard 10 mg dose to be significantly more effective than a placebo.Additionally, two studies published in 2009 examined the effects of phenylephrine on symptoms of allergic rhinitis by exposing sufferers to pollen in a controlled, indoor environment. (drugs.com)
  • Children may be especially sensitive to the effects of phenylephrine. (mayoclinic.org)
  • Appropriate studies have not been performed on the relationship of age to the effects of phenylephrine injection in the pediatric population. (mayoclinic.org)
  • Common side effects of phenylephrine include nausea, vomiting, and headache. (medicineshoppe.com)
  • The pressor effects of phenylephrine may be slightly reduced by lithium carbonate. (medicines.org.uk)
  • The effects of phenylephrine may be potentiated by the use of monoamine oxidase inhibitors or reversible inhibitors of monoamine oxidase. (medicines.org.uk)
  • Phenylephrine is a medication primarily used as a decongestant, to dilate the pupil, to increase blood pressure, and to relieve hemorrhoids. (wikipedia.org)
  • Phenylephrine is used as a decongestant sold as an oral medicine or as a nasal spray. (wikipedia.org)
  • Phenylephrine is used as an alternative for pseudoephedrine in decongestant medicines due to pseudoephedrine's use in the illicit manufacture of methamphetamine. (wikipedia.org)
  • Pharmacists Leslie Hendeles and Randy Hatton of the University of Florida suggested in 2006 that oral phenylephrine is ineffective as a decongestant at the 10-mg dose used, arguing that the studies used for the regulatory approval of the drug in the United States in 1976 were inadequate to prove effectiveness at the 10-mg dose and safety at higher doses. (drugs.com)
  • Guaifenesin/phenylephrine is a medication that contains two different drugs , an expectorant ( guaifenesin ) and a decongestant (phenylephrine). (medicinenet.com)
  • PHENYLEPHRINE (fen il EF rin) is a decongestant. (nationwidechildrens.org)
  • Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. (cigna.com)
  • Check the label to see if a medicine contains phenylephrine or a decongestant. (cigna.com)
  • Phenylephrine is a decongestant that helps relieve stuffy nose and ear congestion symptoms.Cough-and-cold products do not cure or shorten the length of the common cold and may cause serious side effects if not used properly. (medicinenet.com)
  • Phenylephrine HCl acts as a mydriatic, nasal decongestant, and cardiotonic agent. (tradeindia.com)
  • Phenylephrine is used as decongestant for the temporary relief of stuffy nose, ear symptoms, sinus and ear infections and some breathing problems like sinusitis and bronchitis. (rebates.com)
  • Phenylephrine is a decongestant that is used to treat stuffy nose and sinus congestion caused by the common cold , hay fever , or other allergies . (emedicinehealth.com)
  • Phenylephrine belongs to a group of medicines called decongestant. (mims.com)
  • Phenylephrine Hydrochloride is an alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent. (reportsnreports.com)
  • Phenylephrine has been used as an intracameral injection into the anterior chamber of the eye to arrest intraocular bleeding occurring during cataract and glaucoma surgery. (wikipedia.org)
  • Phenylephrine injection is used to treat hypotension (low blood pressure) that may occur during surgery. (mayoclinic.org)
  • Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of phenylephrine injection in the elderly. (mayoclinic.org)
  • However, elderly patients are more likely to have kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving phenylephrine injection. (mayoclinic.org)
  • A formulation for preparing Phenylephrine Hydrochloride 10-mg/mL Injection. (ijpc.com)
  • LAKE ZURICH, Ill. , August 30, 2019 - Fresenius Kabi announced today the immediate availability in the United States of Phenylephrine Hydrochloride Injection, USP. (fresenius-kabi.com)
  • Fresenius Kabi Phenylephrine Hydrochloride Injection, USP is available as a 1 mL single dose vial and as 5 mL and 10 mL pharmacy bulk packages. (fresenius-kabi.com)
  • Fresenius Kabi is pleased to expand our anesthesia and analgesia portfolio with these three presentations of Phenylephrine Hydrochloride Injection," said John Ducker, president and CEO of Fresenius Kabi USA. (fresenius-kabi.com)
  • Phenylephrine Injection is contraindicated in patients with a hypersensitivity to it or any of its components. (fresenius-kabi.com)
  • Phenylephrine Hydrochloride Injection is an alpha-1 adrenergic receptor agonist indicated for treatment of clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia. (fresenius-kabi.com)
  • This Important Safety Information does not include all the information needed to use Phenylephrine Injection, USP, safely and effectively. (fresenius-kabi.com)
  • Please click on this link ( https://tinyurl.com/y2fla2e5 ) for the full prescribing information for Phenylephrine Injection, USP. (fresenius-kabi.com)
  • Phenylephrine Injection is indicated in adults and children for the treatment of hypotensive states e.g. circulatory failure, during spinal anaesthesia or drug induced hypotension. (mountainside-medical.com)
  • Phenylephrine for injection is a prescription medication used to increase blood pressure during surgical procedures requiring anesthesia. (medicineshoppe.com)
  • Sandoz announced a voluntary recall of four lots of Phenylephrine HCI Injection, USP, 10mg/mL, 5mL and 10mL vials due to concerns of product sterility during an inspection at Allergy Laboratories, Inc. While there have been no reported illnesses or injuries, administration of compromised sterile products may result in serious or potentially life-threatening infections or death. (empr.com)
  • Phenylephrine injection may be administered subcutaneously or intramuscularly in a dosage of 2 to 5 mg with further doses of 1 to 10 mg if necessary according to response, or in a dose of 100 to 500 micrograms by slow intravenous injection as a 0.1% solution, repeated as necessary after at least 15 minutes. (medicines.org.uk)
  • Great care should be exercised in administering Phenylephrine Injection to patients with pre-existing cardiovascular disease such as ischaemic heart disease, arrhythmias, occlusive vascular disease including arteriosclerosis, hypertension or aneurysms. (medicines.org.uk)
  • An increased risk of arrhythmias may also occur if phenylephrine injection is given to patients receiving cardiac glycosides, quinidine or tricyclic antidepressants. (medicines.org.uk)
  • Take phenylephrine exactly as directed. (medlineplus.gov)
  • do not take phenylephrine if you are taking a monoamine oxidase (MAO) inhibitor, such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking one of these medications within the past 2 weeks. (medlineplus.gov)
  • If your doctor has told you to take phenylephrine regularly, take the missed dose as soon as you remember it. (medlineplus.gov)
  • How should I take phenylephrine? (cigna.com)
  • You might suffer from stomach upset if you take phenylephrine without food. (rebates.com)
  • Do not take phenylephrine rectal rectal suppository by mouth. (chathamhospital.org)
  • Take Phenylephrine exactly as directed by your doctor or according to the instructions on the label. (mims.com)
  • Do not take Phenylephrine if you are currently taking or have taken a medicine to treat depression known as a monoamine oxidase inhibitor (MAOI) in the last 14 days. (mims.com)
  • What is guaifenesin, phenylephrine, and how does it work (mechanism of action)? (medicinenet.com)
  • What brand names are available for guaifenesin, phenylephrine? (medicinenet.com)
  • Is guaifenesin, phenylephrine available as a generic drug? (medicinenet.com)
  • Do I need a prescription for guaifenesin, phenylephrine? (medicinenet.com)
  • What are the side effects of guaifenesin, phenylephrine? (medicinenet.com)
  • What is the dosage for guaifenesin, phenylephrine? (medicinenet.com)
  • Guaifenesin/phenylephrine may be taken with or without food. (medicinenet.com)
  • Which drugs or supplements interact with guaifenesin, phenylephrine? (medicinenet.com)
  • Is guaifenesin, phenylephrine safe to take if I'm pregnant or breastfeeding? (medicinenet.com)
  • Thus, guaifenesin/phenylephrine should be used in pregnancy only if the physician feels that the potential benefits outweigh the potential risks. (medicinenet.com)
  • What else should I know about guaifenesin, phenylephrine? (medicinenet.com)
  • What preparations of guaifenesin, phenylephrine are available? (medicinenet.com)
  • How should I keep guaifenesin, phenylephrine stored? (medicinenet.com)
  • Guaifenesin and phenylephrine ( Sudafed PE Non-Drying Sinus Caplets, (Entex, discontinued) is a drug is prescribed for the relief of sneezing , nasal congestion from the common cold , runny nose , sinusitis , sore throat , or bronchitis . (medicinenet.com)
  • The medicines below all contain the following active ingredient(s): guaifenesin + phenylephrine. (healthdirect.gov.au)
  • Do not use it if you had an allergic reaction to acetaminophen, guaifenesin, phenylephrine, or any other pain, cough, or cold medicines. (limamemorial.org)
  • There are many brands and forms of guaifenesin and phenylephrine available and not all brands are listed on this leaflet. (johnstonhealth.org)
  • You should not use guaifenesin and phenylephrine if you are allergic to it. (johnstonhealth.org)
  • Can I take Amoxicillin with Acetaminophen, Chlorpheniramine Maleate, Phenylephrine? (drugs.com)
  • What is the most important information I should know about chlorpheniramine and phenylephrine? (rexhealth.com)
  • Chlorpheniramine and phenylephrine is a combination medicine used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes. (rexhealth.com)
  • What should I discuss with my healthcare provider before taking chlorpheniramine and phenylephrine? (rexhealth.com)
  • It is not known whether chlorpheniramine and phenylephrine passes into breast milk or if it could harm a nursing baby. (rexhealth.com)
  • Chlorpheniramine, phenylephrine, and pyrilamine can pass into breast milk and may cause side effects in the nursing baby. (unchealthcare.org)
  • What is chlorpheniramine, hydrocodone, and phenylephrine? (emedicinehealth.com)
  • Never use chlorpheniramine, hydrocodone, and phenylephrine in larger amounts, or for longer than prescribed. (emedicinehealth.com)
  • What is the most important information I should know about acetaminophen, doxylamine, and phenylephrine? (rexhealth.com)
  • HealthDay News) The combination of phenylephrine and acetaminophen results in a pharmacokinetic interaction triggering increased plasma phenylephrine levels, according to a letter to the editor published in the March 20 issue of the New England Journal of Medicine . (empr.com)
  • Noting that phenylephrine is commonly substituted for pseudoephedrine in treatments for the common cold, without additional safety or efficacy studies, Hartley C. Atkinson, M.Pharm, Ph.D., from AFT Pharmaceuticals in Takapuna, New Zealand, and colleagues discuss a pharmacokinetic interaction between phenylephrine and acetaminophen. (empr.com)
  • The authors note that in three studies undertaken as part of the development of a new fixed-dose combination containing acetaminophen, ibuprofen, and phenylephrine, there was a pharmacokinetic interaction among the drugs. (empr.com)
  • Administration of 10mg phenylephrine, 1,000mg acetaminophen, and 300mg ibuprofen resulted in a nearly four-fold increase in the maximal plasma concentration of phenylephrine (3,220pg/mL) compared with administration of 10mg phenylephrine alone (874pg/mL), and a two-fold increase in the area under the curve. (empr.com)
  • Multiple variants of acetaminophen combined with phenylephrine are now available on world-wide markets. (empr.com)
  • Phenylephrine relieves stuffy nose by constricting blood vessels in the nasal air passages. (medicinenet.com)
  • Phenylephrine is used for treating problems like stuffy nose, ear infections, various breathing problems like sinusitis and bronchitis. (rebates.com)
  • Phenylephrine is in a class of medications called nasal decongestants. (medlineplus.gov)
  • This topic will discuss the clinical features, diagnosis, and management of poisoning caused by phenylephrine and related decongestants. (uptodate.com)
  • You should not not use this medicine if you are allergic to phenylephrine or to other decongestants. (cigna.com)
  • Phenylephrine or other decongestants are contained in many combination medicines. (cigna.com)
  • When taken by mouth, decongestants such as phenylephrine can also temporarily decrease the production of breast milk with just one or two doses. (netdoctor.co.uk)
  • Do not use it if you had an allergic reaction to phenylephrine or other nasal decongestants. (stlukes-stl.com)
  • If your symptoms do not get better within 7 days or if you have a fever, stop taking phenylephrine and call your doctor. (medlineplus.gov)
  • Is it safe to take more than one phenylephrine hcl 10mg tablet at a time? (drugs.com)
  • A phenylephrine dose of 5mg produced a plasma concentration-time curve that was similar to that seen with administration of 10mg phenylephrine alone. (empr.com)
  • A 2007 study by Wyeth Consumer Healthcare notes that 7 studies available in 1976 support the efficacy of phenylephrine at a 10 mg dosage. (wikipedia.org)
  • Below you will find a typical dosage of phenylephrine. (rebates.com)
  • Interactions of phenylephrine with alpha and beta receptor blocking drugs may be complex. (medicines.org.uk)
  • Minims phenylephrine hydrochloride are single-use preservative-free eye drops that contain the active ingredient phenylephrine. (netdoctor.co.uk)
  • Each 1 ml ampoule contains 10 mg of the active ingredient phenylephrine hydrochloride. (mountainside-medical.com)
  • Childrens sudafed pe cold plus cough tablets contain the active ingredient phenylephrine, which remains a type of chemotherapy medicine called an alkylating agent. (dreamakergifts.com)
  • Before you give a phenylephrine product to a child, check the package label to find out how much medication the child should receive. (medlineplus.gov)
  • Phenylephrine may also be used for purposes not listed in this medication guide. (cigna.com)
  • It is a known fact regarding taking Phenylephrine during pregnancy that the FDA is using a category system to categorize the medication according to their effects on pregnant women. (thepregnancyzone.com)
  • Phenylephrine is both an over-the-counter and a prescription medication. (medicineshoppe.com)
  • This medication page refers to the prescription form of phenylephrine. (medicineshoppe.com)
  • Histinex® HC (phenylephrine, hydrocodone, cpm) is a clear, orange-colored, sugar free, alcohol free syrup with characteristic fruity odor for oral administration. (rxlist.com)
  • It is also not known whether Histinex® HC (phenylephrine, hydrocodone, cpm) Syrup can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. (rxlist.com)
  • Histinex® HC (phenylephrine, hydrocodone, cpm) Syrup should be given to a pregnant woman only if clearly needed. (rxlist.com)
  • Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Histinex® HC (phenylephrine, hydrocodone, cpm) Syrup, a decision should be made whether to discontinue nursing or discontinue the drug, taking into the account the importance of the drug to the mother. (rxlist.com)
  • Extra high strength neocitran total syrup was recalled from reusing the canadian market data in 2015 by sanofi canada because of issues that positions may have affected the delivery of the required amount of the drug, phenylephrine. (dreamakergifts.com)
  • Do not use phenylephrine and pyrilamine if you have taken an MAO inhibitor in the past 14 days. (peacehealth.org)
  • Phenylephrine and pyrilamine are contained in many combination medicines. (peacehealth.org)
  • Beechams cold & flu capsules contain three active ingredients, paracetamol (300mg), phenylephrine (5mg) and caffeine (25mg). (netdoctor.co.uk)
  • If you become pregnant while taking phenylephrine, call your doctor. (medlineplus.gov)
  • Be the first to review Codeine, Phenylephrine, And Triprolidine(Oral) and share your experience with other Everyday Health users. (everydayhealth.com)
  • This information is independently developed by MIMS based on phenylephrine - oral and is provided for your reference only. (mims.com)
  • tell your doctor and pharmacist if you are allergic to phenylephrine, any other medications, or any of the ingredients in phenylephrine preparations. (medlineplus.gov)
  • Phenylephrine and alpha 1 adrenergic agonists are common ingredients in over-the-counter (OTC) cough and cold preparations. (uptodate.com)
  • The low dose of phenylephrine in nasal, ophthalmic and topical preparations makes its unlikely that it will transfer into breastmilk in significant amounts. (e-lactancia.org)
  • The low dose of phenylephrine in nasal, ophthalmic and topical preparations makes it unlikely to transfer into breastmilk in significant amounts. (e-lactancia.org)
  • Phenylephrine HCl is a selective α1-adrenergic receptor agonist intended for the maintenance of an adequate level of blood pressure during spinal and inhalation anesthesia and for the treatment of vascular failure in shock, shock-like states, and drug-induced hypotension, or hypersensitivity. (empr.com)
  • Hypersensitivity to phenylephrine or to any of the excipients listed in section 6.1. (medicines.org.uk)
  • Phenylephrine comes as a tablet, a liquid, or a dissolving strip to take by mouth. (medlineplus.gov)
  • Who should not take Chlorcyclizine-Phenylephrine Tablet, Chewable? (webmd.com)
  • In case you are taking the chewable tablet, then make sure that you chew each tablet completely before swallowing the phenylephrine. (rebates.com)
  • You should not use this medicine if you are allergic to it phenylephrine (often used in certain cold or allergy medicines). (chathamhospital.org)
  • Ask a doctor or pharmacist before using over-the-counter medicines that may contain ingredients similar to phenylephrine rectal. (chathamhospital.org)
  • Other drugs may affect phenylephrine rectal, including prescription and over-the-counter medicines, vitamins, and herbal products. (chathamhospital.org)
  • This list does not include all medicines that may interact with Phenylephrine. (mims.com)
  • Some medicines can affect how phenylephrine works. (stlukes-stl.com)
  • Below you will find the uses of phenylephrine. (rebates.com)
  • It is not known whether phenylephrine will harm an unborn baby. (cigna.com)
  • Phenylephrine can be used topically to prevent symptoms of hemorrhoids. (wikipedia.org)
  • Phenylephrine causes the constriction of vascular smooth muscle and is often used in the treatment of hemorrhoids presumably to narrow the swollen veins and relieve the attendant pain. (wikipedia.org)
  • Phenylephrine rectal is used on the rectum to relieve itching, burning, irritation, and swelling caused by hemorrhoids. (chathamhospital.org)
  • This study will compare the nasal congestion symptom relief of phenylephrine extended release tablets and placebo in participants with allergic rhinitis. (clinicaltrials.gov)
  • The Food and Drug Administration has stood by its 1976 approval of phenylephrine for nasal congestion as the debate continues. (drugs.com)
  • If you use phenylephrine nasal spray more often or for longer than the recommended period of time, your congestion may get worse or may improve but then return. (medlineplus.gov)
  • I've been using phenylephrine 0.5% for nasal congestion for more than 5 years daily, is that bad? (drugs.com)
  • Phenylephrine is used to treat nasal and sinus congestion, or congestion of the tubes that drain fluid from your inner ears, called the eustachian (yoo-STAY-shun) tubes. (cigna.com)
  • Histinex® HC (phenylephrine, hydrocodone, cpm) is indicated for the symptomatic relief of cough , nasal congestion and discomfort associated with upper respiratory tract infections. (rxlist.com)
  • Phenylephrine nasal is used to treat nasal congestion and sinus pressure caused by allergies, the common cold, or the flu. (unchealthcare.org)
  • Using phenylephrine nasal too long can damage the lining of your nasal passages and lead to chronic nasal congestion. (unchealthcare.org)
  • Is Phenylephrine Safe During Pregnancy? (thepregnancyzone.com)
  • It is no wonder that people are concerned whether Phenylephrine is safe during pregnancy. (thepregnancyzone.com)
  • The safety of phenylephrine during pregnancy and lactation has not been established. (medicines.org.uk)
  • Administration of phenylephrine in late pregnancy or labour may cause foetal hypoxia and bradycardia. (medicines.org.uk)
  • If you are giving phenylephrine or a combination product that contains phenylephrine to a child, read the package label carefully to be sure that it is the right product for a child of that age. (medlineplus.gov)
  • These images are a random sampling from a Bing search on the term "Intravenous Phenylephrine. (fpnotebook.com)
  • Since phenylephrine rectal is used on an as needed basis, you are not likely to miss a dose. (chathamhospital.org)
  • MADISON, N.J. and TIGARD, Ore. , April 19, 2013 /PRNewswire/ -- Bausch + Lomb, the global eye health company, and Paragon BioTeck, Inc. today announced that the companies have entered into a license agreement for Bausch + Lomb to commercialize and distribute Paragon's phenylephrine in the United States on an exclusive basis beginning this month. (prnewswire.com)
  • Phenylephrine eye drops are applied to the eye after a topical anesthetic is applied. (wikipedia.org)
  • Children (the 10 per cent strength of phenylephrine eye drops must not be used in this age group). (netdoctor.co.uk)
  • Phenylephrine is also available as nasal drops. (uptodate.com)
  • Increase in esodeviation under cycloplegia with 0.5% tropicamide and 0.5% phenylephrine mixed eye drops in patients with hyperopia and esotropia. (nih.gov)
  • Phenylephrine is commonly used as a vasopressor to increase the blood pressure in unstable patients with hypotension, especially resulting from septic shock. (wikipedia.org)
  • Comparison will be conducted between continuous variable infusions of both drugs (Phenylephrine and Norepinephrine) with starting doses of 0.75 mcg/Kg/min and 0.1 mcg/Kg/min respectively for prophylaxis against Post-spinal hypotension during cesarean delivery. (clinicaltrials.gov)
  • Sepsis was characterized by hypotension (~12 mm Hg), increased heart rate (~80 beats/min), increased renal sympathetic nerve activity (~70%), and blunted pressor responses to phenylephrine and angiotensin II. (sigmaaldrich.com)
  • Phenylephrine Hydrochloride is an alpha-1 adrenergic receptor agonist indicated for increasing blood pressure in adults with clinically important hypotension resulting primarily from vasodilation, in such settings as septic shock or anesthesia. (fresenius-kabi.com)
  • We compared the incidence of intraoperative nausea and vomiting (IONV) in obese patients who received a prophylactic phenylephrine infusion vs those who received bolus dosing for the treatment of spinal-induced hypotension. (springer.com)
  • In this multicentre, double-blinded randomized controlled trial, 160 obese women undergoing elective Cesarean delivery under spinal anesthesia were randomized to receive a prophylactic phenylephrine infusion initiated at 50 μg·min −1 (and titrated according to a predefined algorithm) or 100 μg phenylephrine boluses to treat hypotension. (springer.com)
  • Phenylephrine comes alone and in combination with other medications. (medlineplus.gov)
  • The FDA and has issued a drug safety communication regarding new restrictions for the use of phenylpropanolamine and phenylephrine medications in preschoolaged children and nursing by mothers. (dreamakergifts.com)
  • In this report, LP Information covers the present scenario (with the base year being 2017) and the growth prospects of global Phenylephrine Hydrochloride market for 2018-2023. (reportsnreports.com)
  • Global Phenylephrine Market Report 2018-2023 is a professional and in-depth study on the current state of the global Phenylephrine industry with a focus on the Chinese market. (medgadget.com)
  • The report then estimates 2018-2023 market development trends of Phenylephrine industry. (medgadget.com)
  • Overall, the report provides an in-depth insight of 2018-2023 Global and Chinese Phenylephrine industry covering all important parameters. (medgadget.com)
  • Phenylephrine possesses predominantly alpha-adrenergic effects. (prnewswire.com)
  • GOVIER, W.C.: A positive inotropic effect of phenylephrine mediated by alpha-adrenergic receptors. (springer.com)
  • In obese women undergoing Cesarean delivery with spinal anesthesia, prophylactic phenylephrine infusion was associated with less intraoperative nausea, less need for rescue antiemetics, and reduced early postoperative vomiting. (springer.com)
  • Phenylephrine HCl is also used to overcome paroxysmal supraventricular tachycardia, to prolong spinal anesthesia, and as a vasoconstrictor in regional analgesia. (empr.com)
  • There are no evaluations for Brompheniramine-phenylephrine. (patientslikeme.com)
  • You should not use brompheniramine, dextromethorphan, and phenylephrine if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate. (northshore.org)
  • What should I avoid while taking brompheniramine and phenylephrine? (adventisthealthcare.com)
  • Small amounts of phenylephrine is excreted in breast milk. (medicinenet.com)
  • Phenylephrine can pass into breast milk and may harm a nursing baby. (cigna.com)
  • It's not known if phenylephrine passes into breast milk, or its effect on a nursing infant. (netdoctor.co.uk)
  • Excretion of phenylephrine in breast milk appears to be minimal. (medicines.org.uk)
  • Unlike pseudoephedrine, abuse of phenylephrine is very uncommon. (wikipedia.org)
  • Pseudoephedrine and loratadine-montelukast therapy were found to be significantly more effective than both phenylephrine and placebo. (wikipedia.org)
  • Pseudoephedrine vs. Phenylephrine? (drugs.com)
  • Please explain the difference between pseudoephedrine and phenylephrine, in particular why one works better than the other at different times. (drugs.com)
  • So basically they changed to formulation of Pseudoephedrine to Phenylephrine because Phenylephrine can't be used in producing Methamphetamine. (drugs.com)
  • Incidentally when I was treating it as a cold I consumed a generic version of Nyquil, which reading the bottle used Phenylephrine rather than Pseudoephedrine. (drugs.com)
  • Phenylephrine, more properly known as para-hydroxyephedrine, is a metabolite of pseudoephedrine. (drugs.com)
  • Phenylephrine vs Pseudoephedrine - What's the difference between them? (drugs.com)
  • ED50 of intrathecal ropivacaine for cesarean section under prophylactic infusion of phenylephrine: A consort study. (nih.gov)
  • Then, phenylephrine infusion by a starting rate of 0.75 mcg/Kg/min. (clinicaltrials.gov)
  • Phenylephrine is used as an eye drop to dilate the pupil to facilitate visualization of the retina. (wikipedia.org)
  • Phenylephrine is commonly used by optometrists, ophthalmologists and other physicians to dilate patients' pupils before ocular examinations. (cnbc.com)
  • Ophthalmic phenylephrine in strengths of 2.5 and 10% is used to dilate (enlarge) the pupil. (mayoclinic.org)
  • Phenylephrine can also be used to dilate pupils during medical procedures. (rebates.com)
  • Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. (medlineplus.gov)
  • Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. (medlineplus.gov)
  • Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis. (sigmaaldrich.com)
  • We therefore examined the effects of the α2-adrenergic agonist clonidine on mean arterial pressure, renal sympathetic nerve activity, and pressor responsiveness to phenylephrine and angiotensin II during hypotensive sepsis in conscious sheep. (sigmaaldrich.com)
  • Pressor responses to increasing doses of phenylephrine and angiotensin II were measured at baseline and at 24, 28, and 32 hours of sepsis. (sigmaaldrich.com)
  • Clonidine treatment prevented the further decline in mean arterial pressure, substantially reduced heart rate and renal sympathetic nerve activity and restored pressor responsiveness to both phenylephrine and angiotensin II toward preseptic levels. (sigmaaldrich.com)
  • Phenylephrine is a selective α1-adrenergic receptor activator which results in the constriction of both arteries and veins. (wikipedia.org)
  • R )-(-)-Phenylephrine hydrochloride is an adrenergic agent, which functions as a β-receptor sympathomimetic drug. (sigmaaldrich.com)
  • Phenylephrine is a selective adrenergic receptor agonist and is a part of the phenethylamine class. (rebates.com)
  • Nonprescription cough and cold combination products, including products that contain phenylephrine, can cause serious side effects or death in young children. (medlineplus.gov)
  • Phenylephrine may cause side effects. (medlineplus.gov)
  • Side effects from Phenylephrine may get worse if you take excessive Caffeine. (cvs.com)
  • There may be various side effects that occur during the intake of phenylephrine. (rebates.com)
  • Below you will find a list of side effects associated with phenylephrine. (rebates.com)
  • Serious side effects have been reported with phenylephrine. (medicineshoppe.com)
  • This is not a complete list of phenylephrine side effects. (medicineshoppe.com)
  • Limit caffeine intake (examples: coffee, teas, colas, chocolate and some herbal supplements) while taking Phenylephrine. (cvs.com)
  • If your symptoms do not get better after 3 days of treatment, stop using phenylephrine and call your doctor. (medlineplus.gov)
  • In some cases, there are no symptoms - this happens at times with type 2 Can Phenylephrine Cause High Blood Pressure. (chilloutla.com)
  • This form of Can Phenylephrine Cause High Blood Pressure comes on so gradually that symptoms may not even be recognized. (chilloutla.com)
  • Can Phenylephrine Cause High Blood Pressure develops gradually, but the symptoms may seem to come on suddenly. (chilloutla.com)
  • The symptoms of Can Phenylephrine Cause High Blood Pressure can be very mild. (chilloutla.com)
  • However, you don't know just by your symptoms if you have Can Phenylephrine Cause High Blood Pressure. (chilloutla.com)
  • Repeated use of 2.5 or 10% phenylephrine may increase the chance of problems during treatment with this medicine. (mayoclinic.org)
  • Phenylephrine is a prescription drug that treats sinusitis and bronchitis. (rebates.com)
  • In the eye, phenylephrine acts locally as a potent vasoconstrictor and mydriatic by constricting ophthalmic blood vessels and the radial muscle of the iris. (prnewswire.com)