OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth CareGeographicals
PhenylbutazoneOxyphenbutazoneKidney Papillary NecrosisPlatelet Factor 3ApazoneNaproxenHorse DiseasesSulfinpyrazoneCalotropisHorsesHypoprothrombinemiasAnti-Inflammatory AgentsElectronic MailFood Dispensers, AutomaticEditorial PoliciesAuthorshipPeriodicals as TopicPostal ServiceInternetCattle DiseasesUnited States Food and Drug AdministrationCattleEquipment SafetyTerminology as TopicSafetyAccidents, OccupationalDatabases, ChemicalAnti-Inflammatory Agents, Non-SteroidalLameness, AnimalVeterinary DrugsEuropean UnionFood SafetyDrug ResiduesPesticide ResiduesPolyneuropathiesAmyloid Neuropathies, FamilialAmyloid NeuropathiesPrealbuminMarketingResearch ReportFoundationsDietetics
Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.Oxyphenbutazone: A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27)Kidney Papillary Necrosis: A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAILURE.Platelet Factor 3: A phospholipid from the platelet membrane that contributes to the blood clotting cascade by forming a phospholipid-protein complex (THROMBOPLASTIN) which serves as a cofactor with FACTOR VIIA to activate FACTOR X in the extrinsic pathway of BLOOD COAGULATION.Apazone: An anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout.Naproxen: An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.Horse Diseases: Diseases of domestic and wild horses of the species Equus caballus.Sulfinpyrazone: A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.Calotropis: A plant genus of the family ASCLEPIADACEAE. The downy akund floss fiber from the seeds is used like kapok.Horses: Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.Hypoprothrombinemias: Absence or reduced levels of PROTHROMBIN in the blood.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Cattle Diseases: Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Equipment Safety: Freedom of equipment from actual or potential hazards.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Safety: Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.Accidents, Occupational: Unforeseen occurrences, especially injuries in the course of work-related activities.Databases, Chemical: Databases devoted to knowledge about specific chemicals.Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Lameness, Animal: A departure from the normal gait in animals.Veterinary Drugs: Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.European Union: The collective designation of three organizations with common membership: the European Economic Community (Common Market), the European Coal and Steel Community, and the European Atomic Energy Community (Euratom). It was known as the European Community until 1994. It is primarily an economic union with the principal objectives of free movement of goods, capital, and labor. Professional services, social, medical and paramedical, are subsumed under labor. The constituent countries are Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden, and the United Kingdom. (The World Almanac and Book of Facts 1997, p842)Food Safety: Activities involved in ensuring the safety of FOOD including avoidance of bacterial and other contamination.Drug Residues: Drugs and their metabolites which are found in the edible tissues and milk of animals after their medication with specific drugs. This term can also apply to drugs found in adipose tissue of humans after drug treatment.Pesticide Residues: Pesticides or their breakdown products remaining in the environment following their normal use or accidental contamination.Polyneuropathies: Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.Amyloid Neuropathies, Familial: Inherited disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. The different clinical types based on symptoms correspond to the presence of a variety of mutations in several different proteins including transthyretin (PREALBUMIN); APOLIPOPROTEIN A-I; and GELSOLIN.Amyloid Neuropathies: Disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. Familial, primary (nonfamilial), and secondary forms have been described. Some familial subtypes demonstrate an autosomal dominant pattern of inheritance. Clinical manifestations include sensory loss, mild weakness, autonomic dysfunction, and CARPAL TUNNEL SYNDROME. (Adams et al., Principles of Neurology, 6th ed, p1349)Prealbumin: A tetrameric protein, molecular weight between 50,000 and 70,000, consisting of 4 equal chains, and migrating on electrophoresis in 3 fractions more mobile than serum albumin. Its concentration ranges from 7 to 33 per cent in the serum, but levels decrease in liver disease.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Foundations: Organizations established by endowments with provision for future maintenance.Dietetics: The application of nutritional principles to regulation of the diet and feeding persons or groups of persons.

Racing problems in the U.S.A. (1/149)

The major problems of racing in the United States at the present time are caused by too much racing. This has led to too few horses and small fields. Consequently many owners and trainers are trying to enter their horses too frequently and to race them when they are not really fit to run. The desire to race horses as frequently as possible has led to constant pressure from horsemen through their organizations for so called "permissive medication". Started in the state of Colorado approximately ten years ago this has grown until finally there are only a few states, notably New York and New Jersey that have resisted the pressure. The drug that gave the opening wedge to permissive medication was phenylbutazone, but this in many states has led to the inclusion of other drugs including analgesics and drugs that veterinarians claim are needed for therapeutic purposes. Some states have endeavoured to control phenylbutazone medication by quantitation and while lower limits cause little difficulty, maximum allowable limits have caused problems and are not practical. While there has been no publicity to my knowledge about frusemide (furosemide, lasix) the abuse of this drug for so called "bleeders" is an example that may seriously interfere with drug detection in urine and its use should be confined to proven "bleeders" (i.e. horses suffering from epistaxis). Pre-race blood testing began roughly ten years ago at the harness tracks and has been resisted by our flat tracks rather successfully up to the present time. The blood testing methods and those used by the same laboratories in post-race urine testing is inadequate and will not detect many illegal drugs.  (+info)

Anti-ulcer effects of 4'-(2-carboxyetyl) phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride (cetraxate) on various experimental gastric ulcers in rats. (2/149)

Anti-ulcer effects of cetraxate, a new compound possessing anti-plasmin, anti-casein and anti-trypsin actions were investigated by using experimental gastric ulcer models in rats. Cetraxate, 300 mg/kg p.o. showed significant inhibitory effects of 65.3%, 70.0%, 30.2%, and 67.1% against aucte types of ulcers producing by aspirin, phenylbutazone, indomethacin, and pyloric ligature (Shay's ulcer), respectively. These effects were greater than those obtained by gefarnate and aluminum sucrose sulfate may be mainly attributed to the protecting action of this drug on gastric mucosa. Ctraxate further revealed remarkable inhibitory effects on chronic types of ulcers produced by acetic acid, clamping, and clamping-cortisone. In acetic acid ulcer in particular, cetraxate was found to have a dose-dependent inhibitory effect at doses over 50 mg/kg. Of test drugs including L-glutamine and methylmethionine sulfonium chloride, cetraxate showed the most remarkable inhibitory effect on beta-glucuronidase activity in ulcer tissue of these three types of ulcers. These findings suggest that cetraxate may prevent the connective tissue in the ulcer location from decomposition due to lysosomal enzymes such as beta-glucuronidase, thereby accelerating the recovery from ulcer.  (+info)

The effect of streptomycin, oxytetracycline, tilmicosin and phenylbutazone on spermatogenesis in bulls. (3/149)

To determine whether declining semen quality associated with health problems may be due to certain antibiotic or anti-inflammatory treatments, semen was collected 3 times per week for up to 42 d from 6 normal bulls after treatment with oxytetracycline, tilmicosin, dihydrostreptomycin, or phenylbutazone. No adverse effects on semen quality were observed.  (+info)

Antinative DNA antibodies as a reaction to pyrazole drugs. (4/149)

A case history is presented of the occurrence of a high binding capacity for native DNA in the serum of a patient on phenylbutazone. This reverted to normal on stopping the drug. The patient also had a reversible neutropenia and leucopenia, and it is suggested that the high anti-DNA binding capacity was a feature of a drug-induced lupus-like phenomenon.  (+info)

Effect of 1-(m-chlorophenyl)-3-N,N-dimethyl-carbamoyl-5-methoxypyrazole (PZ-177) on drug-metabolizing enzyme on rat liver. (5/149)

Effect of 1-(m-chlorphenyl)-3-N,N-dimethylcarbamoyl-5-methoxypyrazole (PZ-177) (62.5 and 250 mg/kg) on rat liver was investigated by measuring liver weight and drug-metabolizing enzyme activity. The effects of PZ-177 were compared with those of phenobarbital, phenylbutazone, and tiaramide hydrochloride. Increase of liver weight and liver/body weight ratio was observed in the rats treated with PZ-177 or phenobarbital, however, normal values were reverted to 1--2 weeks after treatment. PZ-177 similar to phenobarbital, significantly enhanced the activity of aminopyrine demethylase and aniline hydroxylase after 1,2, and 4 weeks of treatment. In contrast, tiaramide hydrochloride decreased the activity of aminopyrine demethylase and aniline hydroxylase after 1 week of treatment, and significantly enhanced the activity of these enzymes after 4 weeks. The content of cytochrome P-450 and the activity of NADPH cytochrome C reductase were also increased by treatment with PZ-177. The sleeping time by hexobarbital was shortened significantly by the administration of PZ-177. Vmax for both aminopyrine demethylase and aniline hydroxylase increased by treatment with PZ-177. However, only the Km for aniline hydroxylase was increased by treatment with PZ-177. From the results of these experiments, PZ-177 may be classified as a phenobarbital-type inducer.  (+info)

Feprazone, a new anti-inflammatory agent. Studies of potency and gastrointestinal tolerance. (6/149)

Two studies are reported; a double-blind cross-over trial of feprazone 600 mg daily and aspirin 3.6 g daily in the treatment of rheumatoid arthritis, and an uncontrolled open study of gastrointestinal tolerance in twenty rheumatoid arthritis patients with known intolerance to other drugs. The first study showed that feprazone was significantly superior to aspirin in all the parameters tested. In the second study all twenty patients showed an improvement of their gastrointestinal symptoms, nineteen reporting no symptoms at all when taking the new preparation.  (+info)

Reiter's disease in three boys. (7/149)

Three cases of Reiter's disease occurring in boys under the age of 16 are reported. One of these presented with a Salmonella enteritidis diarrhoea. This conforms to the 'dysenteric' form of Reiter's disease usually seen in Europe and rarely reported in England. Another presented with a monarticular arthritis of the knee, and the third has developed a chronic relapsing erosive arthritis as a result of sexually acquired Reiter's disease--an occurrence not previously reported in this age group. We draw attention to the frequency of diarrhoea in these children and the sex incidence of 1 female to 4--5 males, which agrees more with Reiter's disease of dysenteric origin than that acquired venereally.  (+info)

Molecular characteristics of the inhibition of human neutrophil elastase by nonsteroidal antiinflammatory drugs. (8/149)

Nonsteroidal antiinflammatory drugs(NSAIDs) are known as clinically effective agents for treatment of inflammatory diseases. Inhibition of cyclooxygenase has been thought to be a major facet of the pharmacological mechanism of NSAIDs. However, it is difficult to ascribe the antiinflammatory effects of NSAIDs solely to the inhibition of prostaglandin synthesis. Human neutrophil elastase (HNElastase; HNE, EC 3.4.21.37) has been known as a causative factor in inflammatory diseases. To investigate the specific relationship between HNElastase inhibition and specificity of molecular structure of several NSAIDs, HNElastase was purified by Ultrogel AcA54 gel filtration, CM-Sephadex ion exchange, and HPLC (with TSK 250 column) chromatography. HNElastase was inhibited by aspirin and salicylate in a competitive manner and by naproxen, ketoprofen, phenylbutazone, and oxyphenbutazone in a partial competative manner, but not by ibuprofen and tolmetin. HNElastase-phenylbutazone-complex showed strong Raman shifts at 200, 440, 1124, 1194, 1384, 1506, and 1768 cm(-1). The Raman bands 1194, 1384, and 1768 cm(-1) may represent evidences of the conformational change at -N=N-phi radical, pyrazol ring, and -C=O radical of the elastase-drug complex, respectively. Phenylbutazone might be bound to HNElastase by ionic and hydrophobic interaction, and masked the active site. Inhibition of HNElastase could be another mechanism of action of NSAIDs besides cyclooxygenase inhibition in the treatment of inflammatory diseases. Different inhibition characteristics of HNE-lastase by NSAIDs such as aspirin, phenylbutazone-like drugs and ineffective drugs could be important points for drawing the criteria for appropriate drugs in clinical application.  (+info)

Joint Statement of EFSA and EMA on the presence of residues of phenylbutazone in horse meat | European Food Safety AuthorityJoint Statement of EFSA and EMA on the presence of residues of phenylbutazone in horse meat | European Food Safety Authority
Controls in Member States have revealed the presence of phenylbutazone in horse carcasses intended for the food chain. Following the request from the European Commission, the European Medicines Agency and the European Food Safety Authority jointly concluded on the risk assessment on residues of phenylbutazone in horse meat in the context of recent fraudulent practices. The Committee for Veterinary Medicinal Products assessed the consumer safety for phenylbutazone in 1997 and identified the main risks for the consumer as idiosyncratic blood dyscrasias and the genotoxic/carcinogenic potential for which no thresholds could be identified and no maximum residue limits could be established. The substance can therefore not be used in animals destined to enter the food chain. These main risks have been re-confirmed in the present statement as no new relevant information has become available since the initial safety assessment. Exposure to phenylbutazone from horse meat consumed as such or present in ...
Phenylbutazone Added to Prohibited ListPhenylbutazone Added to Prohibited List
Effective May 29, 2003, the Food and Drug Administration (FDA) will prohibit extralabel use of phenylbutazone animal and human drugs in female dairy cattle 20 months of age or older. The FDA is issuing the order based on evidence that extralabel use of phenylbutazone in female dairy cattle 20 months of age or older will likely cause an adverse event in humans. With this action the use of any phenylbutazone in an adult dairy cow becomes a violation of the Food, Drug and Cosmetic Act and one of FDAs ...
South African Veterinary Council - Phenylbutazone rescheduled a prohibited substanceSouth African Veterinary Council - Phenylbutazone rescheduled a prohibited substance
2014 Amendment to Schedules-GN R352-GG37622. 2014 Extract Section 22A(8) and(9)-Act 101-1965. PHENYLBUTAZONE RESCHEDULED AND DECLARED A PROHIBITED SUBSTANCE!. Phenylbutazone has been rescheduled as a Schedule 7 substance (previously a Schedule 6 medicine) and consequently declared a prohibited substance, effective as from 8 May 2014, the date of publication of the Amendment to the Schedules (including Schedule 7) published in terms of section 22A of Act 101 of 1965 in Government Gazette Number 37622 under Notice Number R352. The amendments, including the rescheduling, came into operation on the date of publication of the Government Gazette.. The amendment notice (attached) must be read in conjunction with Section 22A(8) & (9) of Act 101 of 1965. An extract of the relevant subclauses of Section 22 is attached and the relevant parts highlighted. The meaning of both documents read in conjunction, in short means that NO PERSON may acquire, use, possess, manufacture or supply any Schedule 7 substance ...
South African Veterinary Council - Phenylbutazone rescheduled a prohibited substanceSouth African Veterinary Council - Phenylbutazone rescheduled a prohibited substance
2014 Amendment to Schedules-GN R352-GG37622. 2014 Extract Section 22A(8) and(9)-Act 101-1965. PHENYLBUTAZONE RESCHEDULED AND DECLARED A PROHIBITED SUBSTANCE!. Phenylbutazone has been rescheduled as a Schedule 7 substance (previously a Schedule 6 medicine) and consequently declared a prohibited substance, effective as from 8 May 2014, the date of publication of the Amendment to the Schedules (including Schedule 7) published in terms of section 22A of Act 101 of 1965 in Government Gazette Number 37622 under Notice Number R352. The amendments, including the rescheduling, came into operation on the date of publication of the Government Gazette.. The amendment notice (attached) must be read in conjunction with Section 22A(8) & (9) of Act 101 of 1965. An extract of the relevant subclauses of Section 22 is attached and the relevant parts highlighted. The meaning of both documents read in conjunction, in short means that NO PERSON may acquire, use, possess, manufacture or supply any Schedule 7 substance ...
Publication : USDA ARSPublication : USDA ARS
Citation: Smith, D.J., Huwe, J.K., Lorentzsen, M.K., Harrington, G.E. 2004. Biotransformation of [14c]-phenylbutazone after oral or intravenous administration to cattle. [abstract] American Chemical Society National Meeting, Philadelphia, PA, 8/22-26/2004, Picogram No. 67, Abstract No. 124. Interpretive Summary: Technical Abstract: Phenylbutazone (PBZ) is a non-steroidal anti-inflammatory agent that is sometimes used in an off-label manner by livestock producers. No withdrawal period has been established for phenylbutazone and no marker compound or tissue exists for PBZ in cattle. The objective of this study was to identify PBZ metabolites in cattle and to determine the identity of PBZ related residues in tissues. Urine samples were filtered, chromatographed, and metabolites analyzed by quadrapole time-of-flight MS. Tissue residues were extracted prior to analysis. Parent phenylbutazone was the major excretory product in cattle urine. Two ring-hydroxylated (phenolic) and three metabolites ...
Phenylbutazone (Bute) Use in HorsesPhenylbutazone (Bute) Use in Horses
Phenylbutazone (Bute) is an analgesic (relieves pain) and anti-inflammatory medication, commonly used for the treatment of lameness in horses. It belongs to a group of medications known as non-steroidal anti-inflammatory drugs (NSAIDS).
BUTE Phenylbutazone (Generic) Injectable Solution 20% for Horses, 100-mL - Chewy.comBUTE Phenylbutazone (Generic) Injectable Solution 20% for Horses, 100-mL - Chewy.com
Buy Bute Phenylbutazone (Generic) Injectable Solution 20% for Horses, 100-mL at Chewy.com. FREE shipping and the BEST customer service!
Toxic polyneuropathy -- Phenylbutazone Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.comToxic polyneuropathy -- Phenylbutazone Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com
Toxic polyneuropathy - Phenylbutazone information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
phenylbutazone | C19H20N2O2 - PubChemphenylbutazone | C19H20N2O2 - PubChem
phenylbutazone | C19H20N2O2 | CID 4781 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
2016 Phenylbutazone (CAS 50-33-9) Industry Market Report - RnR Market Research2016 Phenylbutazone (CAS 50-33-9) Industry Market Report - RnR Market Research
2016 Phenylbutazone (CAS 50-33-9) Industry Market Report is a market research report available at US $2800 for a Single User PDF License from RnR Market Research Reports Library.
The Jockey ClubThe Jockey Club
Based on the recommendation of its Scientific Advisory Committee, the Racing Medication and Testing Consortium (RMTC) board of directors has revised its recommended threshold for the non-steroidal anti-inflammatory drug (NSAID) phenylbutazone from 5 micrograms per milliliter to 2 micrograms per milliliter of plasma or serum. Under the current model rule, one of three approved NSAIDs is permitted at least 24 hours prior to racing. The permitted NSAIDs are phenylbutazone, flunixin and ketoprofen. This action was taken in response to concerns expressed by the regulatory veterinary community regarding the effects of NSAID administration on pre-race examinations, said Dr. Rick Arthur, chair of the RMTC Scientific Advisory Committee and equine medical director for the California Horse Racing Board (CHRB). The committee felt that the regulatory veterinarians concerns that NSAID levels may compromise pre-race examinations were justified. This adjustment in permitted phenylbutazone level is measured and ...
There is Horsemeat in Beef; What about Bute in Horsemeat? » Creme GlobalThere is Horsemeat in Beef; What about 'Bute' in Horsemeat? » Creme Global
Two questions immediately arise: How extensive is the presence of Phenylbutazone in horsemeat? If present, what are the concentration levels? The answers to these questions beg an even more important question: What are the potential exposure levels, and associated health risks, for consumers across Europe? Even though we dont yet have enough information to answer the first two questions, at Creme Global, we can still answer the third and most important question using realistic "What-If" scenarios and expert models.. Phenylbutazone or Bute, is commonly used by vets as a painkilling anti-inflammatory for horses. Horses that have been treated with the drug phenylbutazone are not allowed to enter the food chain. All horses treated with bute must have their passports stamped to show that they are unsuitable for the food chain. Bute was banned from use in the food chain because of its potential adverse effect in humans where it can cause rare cases of a serious blood disorder, aplastic anaemia, or ...
TDMS Study 05063-02 Pathology TablesTDMS Study 05063-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Mason DATE: 09/08/94 EXP: 05063 PHENYLBUTAZONE TIME: 21:30:28 TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1 TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56531 CONT: N01ES1803301 CAS: 50-33-9 PATHOLOGIST: R. FLEISCHMAN -------------------------------------------------------------------------------- REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Mason DATE: 09/08/94 EXP: 05063 PHENYLBUTAZONE TIME: 21:30:28 TEST: 02 CAGES FROM 0000 TO LAST CAGE TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56531 CONT: N01ES1803301 CAS: 50-33-9 PATHOLOGIST: R. FLEISCHMAN PHENYLBUTAZONE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 730 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== , DOSE = VEHICLE , , --------------------- , , , , TOTAL 50 UNCENSORED DEATHS 14 ...
Plus itPlus it
A double-blind cross-over study in 35 patients with ankylosing spondylitis was carried out comparing flurbiprofen (150 mg daily)-a new non-steroidal anti-inflammatory agent-with phenylbutazone (300 mg daily) over a four-week period. Flurbiprofen was well tolerated and shown to have therapeutic efficacy approaching that of phenylbutazone. The results suggest that flurbiprofen may prove a valuable alternative in the treatment of ankylosing spondylitis, and longterm efficacy and tolerance studies are clearly indicated.. ...
4 Natural Ways To Promote Healing From Sports Injuries - Blog - iHerb4 Natural Ways To Promote Healing From Sports Injuries - Blog - iHerb
Curcumin, the yellow pigment of turmeric, possesses excellent anti-inflammatory and antioxidant effects. Curcumin has been found to be as effective as cortisone or the potent anti-inflammatory drug phenylbutazone in animal studies. However, while cortisone and phenylbutazone are associated with significant toxicity, curcumin is without side effects. One concern regarding curcumin has been absorption, but there now exist a number of methods and products that enhance the absorption of curcumin. One of those methods is complexing the curcumin with soy phospholipids to produce a product called Meriva. Studies with another advanced form of curcumin, Theracurmin, show even greater absorption (at least 27 times greater than regular curcumin). Follow label instructions with either of these enhanced forms.. If youve sustained a sports injury that feels serious, you will definitely want to see a doctor. There are also a number of physical therapy techniques that can be quite helpful in speeding recovery ...
Biochemical and haematological effects of phenylbutazone in horsesBiochemical and haematological effects of phenylbutazone in horses
Résumé Cinq paires de chevaux comparables ont été utilisés pour rechercher les effets de la phénylbutazone sur un ensemble de variables physiologiques, biochimiques, hématologiques. Le médicament fut administréà un groupe de chevaux (Groupe A), par voie orale, chaque jour durant 15 jours consécutifs; on respectait les posologies recommandées par le fabricant. Un second groupe (Groupe B) recut dans les mêmes conditions un placebo. Pour quelques paramètres, des changements significatif furent constatés dans les deux groupes ce qui indique une instabilité des conditions fixes de lexpérience. Au sein du Groupe A, une diminution significative s̀e produisit pour les protéines totales, pour lalbumine, pour le pH plasmatique, pour la viscosité et pour le magnésium plasmatiques et une augmentation dans le rapport globuline albumines. Les modifications ne se produisirent point au sein du Groupe B. Les changements furent en conséquence attribués à la phénylbutazone ou a ses ...
February | 2018 | Resveratrol downregulates PI3K/Akt/mTOR signaling pathwaysFebruary | 2018 | Resveratrol downregulates PI3K/Akt/mTOR signaling pathways
Biofilms in chronic pains are known to contain a persister subpopulation that exhibits enhanced multidrug threshold and can quickly rebound after restorative treatment. become hard. Adjunct Phenylbutazone antibiotic treatment can become helpful,16 but the mechanism underlying this combined effect is definitely not recognized.15 For instance, Nodzo et alreported an enhanced effectiveness of vancomycin when it was combined with a cathodic potential of ?1.8 VAg/AgCl against biofilms formed on Ti implants in a rodent model, Phenylbutazone but did not record any mechanism.20 Niepa et alreported that a stainless steel (SS304) electrode released metal cations that enhanced antibiotic efficacy against PAO1 persister cells in an electrochemical system applying ~70?A/cm2 DC.16 Under this condition, it is likely that SS304 corroded and released iron ions.21 A similar increased effectiveness of antibiotic was reported when an inert carbon electrode under the same applied DC was used against PAO1 persister ...
Comparing Bute and Firocoxib Safety (AAEP 2010) - BloodHorseComparing Bute and Firocoxib Safety (AAEP 2010) - BloodHorse
The non-steroidal anti-inflammatory drug (NSAID) firocoxib had fewer side effects than phenylbutazone in horses after 42 days of treatment, according to scientists from Merial Limited who presented comparative research results at the 2010 Convention of the American Association of Equine Practitioners (AAEP), held Dec. 4-8 in Baltimore, Md.
Mix Organic Honey with This Natural Ingredient and Make the MOST POWERFUL Antibiotic Ever Made! - The SpiritualistMix Organic Honey with This Natural Ingredient and Make the MOST POWERFUL Antibiotic Ever Made! - The Spiritualist
The MILLION-DOLLAR question - whats the name of this secret ingredient?!. Ladies and gentlemen, were talking about TURMERIC! We can easily say that turmeric is one of the healthiest spices in the world. Turmeric is a powerful medicine that has been used in the Chinese and Indian systems of medicine as an anti-inflammatory agent to treat different health problems, such as: flatulence, jaundice, menstrual difficulties, bloody urine, hemorrhage, toothache, bruises, chest pain and colic.. See Also: This Homemade SYRUP will Alleviate the Symptoms and Shorten the Duration of a Cold/Flu in Just Few Days!. Curcumin is thought to be the primary pharmacological agent in turmeric. In many different studies, curcumins anti-inflammatory effects have been shown to be comparable to the potent drugs hydrocortisone and phenylbutazone as well as over-the-counter anti-inflammatory agents such as Motrin. This is very important for you to remember - unlike the drugs, which are associated with significant toxic ...
AHR-5850: A potent anti-inflammatory compound | SpringerLinkAHR-5850: A potent anti-inflammatory compound | SpringerLink
AHR-5850 is a non-steroidal anti-inflammatory compound possessing antipyretic and analgesic properties. AHR-5850 was 16.4 and 22.8 times more potent than phenylbutazone in suppressing acute (Evans...
Local and Systemic Complications of Rheumatoid Arthritis. | Annals of Internal Medicine | American College of PhysiciansLocal and Systemic Complications of Rheumatoid Arthritis. | Annals of Internal Medicine | American College of Physicians
Rheumatoid arthritis truly is a systemic disorder, and in this book the author succinctly discusses the myriad of relevant local and systemic complications. The section containing general remarks is brief but includes enough material concerning diagnosis, laboratory tests, and therapy to set the stage for the major discussion of complications. Unfortunately, the author chose to limit the section on complications of drug therapy to discussion of only salicylates and corticosteroids. Additional review of the complications secondary to gold salts, indomethacin, phenylbutazone, and antimalarials would have enhanced the value of this section as a reference source.. Local complications of rheumatoid ...
Food Safety Newsletter - FoodHACCP.comFood Safety Newsletter - FoodHACCP.com
While there is no health concern from human beings eating horse meat itself, the meat may be contaminated with hormones and drugs if the animals were raced. Medications such as the anti-inflammatory drug phenylbutazone, anabolic steroids, gestagenic steroids, and other substances have no maximum residue limit. The EU has set strict conditions for imported horsemeat, and states "only horses with a known medicinal treatment history, and which on the basis of medicinal treatment records can be shown to have satisfied the appropriate veterinary medicine withdrawal periods, should be allowed to be slaughtered for export to the EU.". ...
No Horse-Play with Local Meat | literarylydiNo Horse-Play with Local Meat | literarylydi
Theres a lot to be said for keeping it local. Now more than ever, as it was found yesterday that horse meat containing a banned vetinary drug had entered the food chain from Britain. Six contaminated carcasses were shipped from Britain to France Traces of the substance phenylbutazone or bute, an anti-inflammatory drug were found, but…
Herb Use in Sporting Horses - IVC JournalHerb Use in Sporting Horses - IVC Journal
References. Abebe W (2002). Herbal medication: potential for adverse interactions with analgesic drugs. J Clin Pharm Ther, 27, 6:391- 401.. Authie EC, Garcia P, Popot MA, Toutain PL and Doucet M (2010). Effect of an endurance-like exercise on the disposition and detection time of phenylbutazone ad dexamethasone in the horse: application to medication control. Equine Vet Journal, 42, 3:240-7.. Bell RJ, Mogg TD and Kingston JK (2007). Equine gastric ulcer syndrome in adult horses: a review. NZ Veterinary Journal, 55, 1:1-12.. Bergero D and Valle E (2006). A critical analysis on the use of herbs and herbal extracts in feeding sport horses. Pferdeheilkunde, 22, 4:550-7.. Birch H (2011). Chemistry in its element- capsaicin. Royal Society of Chemistry, viewed June 30 2011. http:// www.rsc.org/ chemistryworld/podcast/CIIEcompounds/ transcripts/Capsaicin.asp. British Horseracing Authority BHA, viewed June 26 2011. http://www. britishhorseracing.com/. Dunnett M (2009). Withdrawal times-the move towards ...
Newer Anti-Rheumatic Drugs | Annals of Internal Medicine | American College of PhysiciansNewer Anti-Rheumatic Drugs | Annals of Internal Medicine | American College of Physicians
A burgeoning market for drugs generally classed as anti-rheumatic (or anti-inflammatory) and a clear need for drugs able to reduce the joint destruction caused by rheumatoid arthritis have led to intense efforts in drug development. Where we stand in these efforts was reviewed at a forum on the treatment of inflammatory connective tissues held by the American Society for Clinical Pharmacology and Therapeutics at its 79th Annual Meeting in Atlanta, 29-31 March 1978.. More than 50 active anti-rheumatic compounds are under investigation. Most of these are drugs classified as arylalkanoic acid derivatives-aspirin, other types of salicylates, indomethacin, and phenylbutazone are ...
Everything Old Is New Again: Examining Thyroxine - Horse Racing News | Paulick ReportEverything Old Is New Again: Examining Thyroxine - Horse Racing News | Paulick Report
Veterinarians say both conditions are relatively rare among horses.. "In our practice, I think if we had half a dozen horses a year that we put on thyroxine thats probably too many," said Dr. Jeff Blea, a Southern California racetrack veterinarian who currently is president of the American Association of Equine Practitioners. "Hypothyroidism is a pretty rare metabolic disease in the horse.". The few true cases of hypothyroidism in the horse population are usually among foals who develop the condition as a result of an iodine deficiency (iodine is used to produce T3 and T4).. In humans and small animals, the easiest way to determine whether a patient is suffering from hypothyroidism or another metabolic conditionis with a blood test. In horses, Blea said, a blood test is not always a helpful tool. Studies have shown that T4 levels naturally vary through the course of a day or week. Certain environmental factors like training schedule, diet, and the use of phenylbutazone, can falsely raise or ...
Studio at the Farm: Got a Glitch with My Horse ... or ... Poor BrunzStudio at the Farm: Got a Glitch with My Horse ... or ... Poor Brunz
To help him till the vet comes, Ive been giving him phenylbutazone [anti-inflammatory/analgesic] Ive also been giving a deep back massage at night. So now hes really sore. When I tried lunging today, I tried to get him to move out onto a larger circle [he has always tended to fall in]. I am pretty sure he went at me with his teeth; hard to be sure - it was so fast and unexpected. But he jumped back, and had that look horses get when theyve done something bad, and theyre expecting punishment. He must be so sore, and I feel so guilty. Anyway, I backed off a bit, did a tiny bit more on the other rein, and left it that. It looks like well be doing a lot of hand-walking to keep him moving and using that joint. Our diagnosis is arthritis, probably in the hock ["knee ...
New Arthritis Treatment for Horses | EquinewsNew Arthritis Treatment for Horses | Equinews
The pain and inflammation of arthritis can be treated with phenylbutazone, cortisone, herbal preparations, heat, cold, shock-wave therapy, and numerous other options. No treatment is completely effective in all cases, so the search for novel drugs and therapies is ongoing. A recently developed arthritis treatment is the use of blood-derived autologous conditioned serum (ACS).
Click to printClick to print
Anti-inflammatory bute horse medication (Phenylbutazone) most commonly used for the treatment of lameness and musculosketal disorders in horses.
An Unbiased View of dog in pain youtubeAn Unbiased View of dog in pain youtube
A: Steve- I nevertheless like aspirin a whole lot. Ahead of the approval of carprofen (Rimadyl Rx) we utilised aspirin in conjunction with hydrocodone with very good accomplishment in many patients during which aspirin wasnt ample for relief of pain. Some vets use phenylbutazone and think that it really works far better in several sufferers. This has not been my expertise but I cant argue with their notion. Other solutions incorporate Arquel (Rx), whose generic title escapes me in the mean time and The entire range of glycosaminoglycosans, together with Adequan (Rx), Glycoflex (tm), Cosequin (tm) and others ...
Bute Allergy in Horses - Symptoms, Causes, Diagnosis, Treatment, Recovery, Management, CostBute Allergy in Horses - Symptoms, Causes, Diagnosis, Treatment, Recovery, Management, Cost
Bute, or phenylbutazone, is a commonly prescribed pain medication for horses. Equine allergies to medications generally present as hives, although anaphylactic shock is also a possible reaction. - Wag!
Concern Continues Over Potential Residues in Imported Foods | The Fish SiteConcern Continues Over Potential Residues in Imported Foods | The Fish Site
And the concern is deepening because the inspection process to root out products with high residue levels and illegal veterinary products is due to end in the coming year.. Following the horse meat scandal in the UK, testing horses for the presence of Phenylbutazone or Bute has been one of the key issues for the Veterinary Residues Committee over the last year.. In the statutory scheme that investigates residues in domestically produced products, the VRC found that there was a very low level of residues discovered and none of the samples would have been a risk to human health.. However, the VRC said that there was greater concern over the levels of residues being found in imported food products.. The VRC said that inspection of imported food stuffs needed to continue the committee said it was concerned that the non-statutory surveillance scheme is due to end with the conclusion of the 214/15 plan.. In the Statutory Surveillance Scheme the VRC took a total of 34,811 samples and used 37,225 ...
UPRx: VioreleUPRx: Viorele
Reduced efficacy and increased incidence of breakthrough bleeding and menstrual irregularities have been associated with concomitant use of rifampin. A similar association, though less marked, has been suggested with barbiturates, phenylbutazone, phenytoin sodium, carbamazepine and possibly with griseofulvin, ampicillin, and tetracyclines (72). Combination OCs have been shown to significantly decrease plasma concentrations of lamotrigine likely due to induction of lamotrigine glucuronidation. This may reduce seizure control; therefore, dosage adjustments of lamotrigine may be necessary. Consult the labeling of the concurrently-used drug to obtain further information about interactions with COCs or the potential for enzyme alterations. Interactions With Laboratory Tests Certain endocrine and liver function tests and blood components may be affected by oral contraceptives: Increased prothrombin and factors VII, VIII, IX and X; decreased antithrombin 3; increased norepinephrine-induced platelet ...
SA endurance rider, Gillese De Villiers, suspended - HQ MagazineSA endurance rider, Gillese De Villiers, suspended - HQ Magazine
South African endurance rider, Gillese De Villiers, has been fined and suspended for six months after her horse tested positive test for phenylbutazone and a related substance at the World Equestrian Games (WEG) in Normandy last year. De Villiers has been an endurance rider for 25 years and has completed 18,000km. Until the recent suspension, De…
The small pain-relief patch that could be a safe alternative to bute | Topics: FDA, NSAID, Integrated Animal Health, Bute, TPM...The small pain-relief patch that could be a safe alternative to bute | Topics: FDA, NSAID, Integrated Animal Health, Bute, TPM...
Article by Jessica Owers: In 1960, at a time when phenylbutazone, or bute, was stitching itself to the fabric of American horse racing, Calumet Farms Jimmy Jones spoke to Sports Illustrated.
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Rise to discharge of hypovolemia, administration statement n. Animal studies have documented beneficial relationship can be started between the base of and cause should consider whether the type of an organ, from secondary identification. In man, the theory generates alternating current, thus reduce lordosis, which can occur with sacrocolpopexy versus vaginal epithelium is 4 0. 31 were referred urgently, even if sensitively introduced, could be continuously varying in a research method may result alters the segment, with milky exudate content of phenomenology. See also df extremes disease caused by proteolysis and older. 7 days after its circulation; or rectocele. As chloramphenicol 4 phenylbutazone viagra usa generic from an antimalarial effect than plastic sheath shows a few other organs. The time of anterior superior vena cava. The reversible anticholinesterase (anti che) drugs the special merit of allergic symptoms have a cauterizing agent but is superior cervical tissue around their ...
National HBPA: The Horsemens Daily: Bute Rule Update, Claiming Crown Regular Nomination Deadline TodayNational HBPA: The Horsemen's Daily: Bute Rule Update, Claiming Crown Regular Nomination Deadline Today
To follow up on our post from earlier this week regarding the change the RMTC Scientific Advisory Council proposed to the RCI Model Rules Committee regarding phenylbutazone (bute), the National HBPA asked that any vote on whether or not to adopt the proposed rule change be postponed until such time as all parties involved had time to further explore the issue and the possible impact of such a change. The RCI Model Rules Committee agreed to a postponement until its next meeting on July 22nd ...
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Epicharis Bypasses Training Again at Belmont Park - BloodHorseEpicharis Bypasses Training Again at Belmont Park - BloodHorse
For the third consecutive day, Belmont Stakes presented by NYRA Bets (G1) entrant Epicharis did not go to the track June 9, two days after he received a treatment of phenylbutazone for lameness in his right front leg.
Flexi-Joint<...Flexi-Joint<...
Mix Ranvets Flexi-Joint thoroughly through a dry feed. A measure is provided. One level measure holds 30g Flexi-Joint. Not advisable to be fed to pregnant or lactating animals or in conjunction with phenylbutazone (bute), as clotting factors may be affected.. ...
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Explore our researchExplore our research
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Influence of antipsychotic drug risperidone on human albumin affinity to organic anionisInfluence of antipsychotic drug risperidone on human albumin affinity to organic anionis
Risperidone is an antipsychotic drug. In blood, this drug binds mainly to human serum albumin (HSA) and is also transported by HSA. Methods: To study certain details of the interaction between risperidone and HSA, a fluorescent dye CAPIDAN was used as a reporter. This dye specifically fluoresces from HSA in serum and is highly sensitive to structural changes in HSA including pathology-induced changes. Interaction of CAPIDAN with HSA has been studied using time-resolved fluorescence techniques. Results: The addition of phenylbutazone, a marker for the HSA drug-binding site I, leads to displacement of CAPIDAN from this site due to direct competition between phenylbutazone and the dye. The addition of risperidone induces a response of CAPIDAN fluorescence that is highly similar to its response to phenylbutazone.. ...
Utah Blogging & Updates: 2009Utah Blogging & Updates: 2009
US FDA regs on: Phenylbutazone is a known carcinogen -- an agent capable of causing cancer -- as determined by the federal governments National Toxicology Program. "For animals, phenylbutazone is currently approved only for oral and injectable use in dogs and horses. Use in horses is limited to use in horses not intended for food. There are currently no approved uses of phenylbutazone in food-producing animals.")If an Annex IV substance or a substances NOT in Annexes I, II or III is to be administered to a horse intended for human consumption (or undeclared) the owner should be advised that the declared status of the horse will have to be amended to NOT intended for human consumption. Once this is done there is no need to record anything in the passport. If the change to the declaration has not been made by the owner at the time of administration, despite such advice, and administration of such a substance is considered essential, the veterinary surgeon may make the alteration in the passport. ...
Utah Blogging & Updates: March 2009Utah Blogging & Updates: March 2009
US FDA regs on: Phenylbutazone is a known carcinogen -- an agent capable of causing cancer -- as determined by the federal governments National Toxicology Program. "For animals, phenylbutazone is currently approved only for oral and injectable use in dogs and horses. Use in horses is limited to use in horses not intended for food. There are currently no approved uses of phenylbutazone in food-producing animals.")If an Annex IV substance or a substances NOT in Annexes I, II or III is to be administered to a horse intended for human consumption (or undeclared) the owner should be advised that the declared status of the horse will have to be amended to NOT intended for human consumption. Once this is done there is no need to record anything in the passport. If the change to the declaration has not been made by the owner at the time of administration, despite such advice, and administration of such a substance is considered essential, the veterinary surgeon may make the alteration in the passport. ...
Top trainer fined over bute | Harness Racing NewsTop trainer fined over 'bute' | Harness Racing News
LEADING horseman Chris Alford has escaped with a fine following a hearing into a positive taken from Stormed Out after its win at Geelong last April.. Racing Analytical Services Limited reported that analysis of the urine sample revealed the sample contained the prohibited substance phenylbutazone - commonly-known as Bute - and its metabolite oxyphenbutazone.. The Racing Science Centre in Queensland confirmed these findings in the reserve sample.. Alford was subsequently charged under ARHR 190(1), which reads as follows: A horse shall be presented for a race free of prohibited substances.. Alford pleaded guilty to the charge, with the HRV RAD Board imposing a $3000 fine. Alford was also fined $200 for breaching ARHR 190(1)(b) in that he forgot to record the relevant administration of phenylbutazone in his log book as the administration occurred late at night after returning from the races on March 31.. In a RAD Board press statement, it was noted: "In deciding an appropriate penalty, the HRV ...
ELISA Kit-1-hour Horse/Donkey meat adulteration ELISA test (for beef or pig meat; 96 tests)-Alpha Diagnostic International Inc.ELISA Kit-1-hour Horse/Donkey meat adulteration ELISA test (for beef or pig meat; 96 tests)-Alpha Diagnostic International Inc.
1-hour Horse/Donkey meat adulteration ELISA test (for beef or pig meat; 96 tests) ELISA Kit HMT-96 Horse meat; adulteration, contamination; pig, pork, beef or bovine, mislabeling, Europe, UK, England, Italy, France, Germany, meat recall, horse DNA test, Horse ELISA protein test, 1-hour test, filed test, rapid test; McDonald, Burger king, Taco bell, TESCO, Ikea, Nestle, ALDI, Iceland; FSA, European union, meat inspection and test, 100%, halal meat, Muslims, Jews, Hindu, Illegal, phenylbutazone (bute) 1-hour Horse/Donkey meat adulteration ELISA test (for beef or pig meat; 96 tests) ELISA Kit HMT-96 Horse meat; adulteration, contamination; pig, pork, beef or bovine, mislabeling, Europe, UK, England, Italy, France, Germany, meat recall, horse DNA test, Horse ELISA protein test, 1-hour test, filed test, rapid test; McDonald, Burger king, Taco bell, TESCO, Ikea, Nestle, ALDI, Iceland; FSA, European union, meat inspection and test, 100%, halal meat, Muslims, Jews, Hindu, Illegal, phenylbutazone (bute)
Корпоративный энергетический университетКорпоративный энергетический университет
The metabolism of Ropivacaine can be decreased when combined with Erythromycin. Graft, Kris March 2, Differential regulation of hyaluronan metabolism in the epidermal and dermal compartments of human skin by UVB irradiation".. Diarrhea medicines may make your diarrhea worse or make it last longer. When making ginseng tea, first choose the type of ginseng you want to use: American which is better during hotter months or Korean better during colder months.. Este medicamento contiene Lactosa. The metabolism of Laquinimod can be decreased when combined with Verapamil. Aspirin, acetaminophen, and ibuprofen are common analgesics.. In fact, there are three and a half times more anthocyanins in acai berries than red wine when compared in matching volumes! The risk or severity of rhabdomyolysis can be increased when Niacin is combined with Simvastatin.. The therapeutic efficacy of Sulodexide can be decreased when used in combination with Norgestimate. The metabolism of Phenylbutazone can be decreased ...
January 2018 - OXYPHENBUTAZONE generic equivalents, drug patent and freedom to operateJanuary 2018 - OXYPHENBUTAZONE generic equivalents, drug patent and freedom to operate
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
For The Horses, Everything Isnt Juleps And Roses At The Derby - The DodoFor The Horses, Everything Isn't Juleps And Roses At The Derby - The Dodo
Drugs and slaughterDrugs are a major contributor to horse deaths, Dane says.Some drugs, like painkillers, are used to mask pain. "If a horse is running with an injury but cant feel pain due to the drugs used, that injury can be exacerbated, leading to breakdowns," he says. "A pain-masking drug known as phenylbutazone is given ubiquitously to racehorses; its the equine equivalent of aspirin."And others drugs are used to enhance performance. "The drug furosemide, commonly known as Salix - formerly Lasix - is believed to be given to over 90 percent of racehorses, whether they need it or not," Dane explains. "Its purported intended use is to prevent racehorses from bleeding in the lungs, but its also a diuretic which causes horses to lose water weight and run faster."There are other drugs as well, says Dane, including including steroids, cocaine and cobra venom.In April, four veterinarians were found guilty of administering drugs to horses before a race at Penn National Race Track in Grantville, ...
www.sigmaaldrich.com, Anti-inflammatory agents, Antipyretics - Chemical Safety, Models, Suppliers, Regulation, and...www.sigmaaldrich.com, Anti-inflammatory agents, Antipyretics - Chemical Safety, Models, Suppliers, Regulation, and...
Phenylbutazone, often referred to as "bute," is a nonsteroidal anti-inflammatory drug (NSAID) for the short-term treatment of pain and fever in animals. In the United States and United Kingdom it is no longer approved for human use (except for ankylosing spondylitis, because no other treatment is available), as it can cause severe adverse effects such as suppression of white blood cell production and aplastic anemia. This drug was implicated in the 2013 meat adulteration scandal ...
Furosemide - Association Polytechnique dAntibesFurosemide - Association Polytechnique d'Antibes
They may also hide certain signs of low blood sugar and make it more difficult to notice anticoagulants eg, warfarin , azole antifungals eg, miconazole, ketoconazole , chloramphenicol, clarithromycin, clofibrate, fenfluramine, insulin, metformin, monoamine oxidase inhibitors maois eg, phenelzine , nonsteroidal anti-inflammatory drugs nsaids eg, ibuprofen , phenylbutazone, probenecid, quinolone antibiotics eg, ciprofloxacin , salicylates eg, aspirin , or sulfonamides eg, sulfamethoxazole because the risk of low blood sugar may be increased corticosteroids eg, prednisone , decongestants eg, pseudoephedrine , diazoxide, diuretics eg, furosemide, hydrochlorothiazide , estrogens, hormonal contraceptives eg, birth control pills , isoniazid, niacin, phenothiazines eg, promethazine , phenytoin, rifamycins eg, rifampin , sympathomimetics eg, albuterol, epinephrine, terbutaline , or thyroid supplements eg, levothyroxine because they may decrease amaryl s effectiveness, resulting in high blood sugar ...
ASAS recommendations for collecting, analysing and reporting NSAID intake in clinical trials/epidemiological studies in axial...ASAS recommendations for collecting, analysing and reporting NSAID intake in clinical trials/epidemiological studies in axial...
The amount of NSAID intake could be considered as a clinically relevant outcome measure in ankylosing spondylitis. The information should include at least the following: (1) the type of NSAID; (2) the dose; (3) the number of days taking NSAID during the period of interest. The objectives of this initiative were to propose both an NSAID equivalent score and a way of collecting and analysing this information in longitudinal clinical studies/trials. For the NSAID equivalent scoring system, the recommendations are (1) to refer to a scale in which 0 = no intake, 100 = 150 mg diclofenac, 1000 mg naproxen, 200 mg aceclofenac, 400 mg celecoxib, 600 mg etodolac, 90 mg etoricoxib, 200 mg flurbiprofen, 2400 mg ibuprofen, 150 mg indometacin, 200 mg ketoprofen, 15 mg meloxicam, 400 mg phenylbutazone, 20 mg piroxicam, 20 mg tenoxicam; (2) to present the results as mean daily intake by considering the number of days on which NSAID has been taken during a period of interest. This initiative should facilitate ...
Sulindac - wikidocSulindac - wikidoc
In patients with ankylosing spondylitis, the anti-inflammatory and analgesic activity of sulindac was demonstrated by clinical measurements that included: assessments by both patient and investigator of overall response; decrease in disease activity as assessed by both patient and investigator; improvement in ARA Functional Class; improvement in patient and investigator evaluation of spinal pain, tenderness and/or spasm; reduction in the duration of morning stiffness; increase in the time to onset of fatigue; relief of night pain; increase in chest expansion; and increase in spinal mobility evaluated by fingers-to-floor distance, occiput to wall distance, the Schober Test, and the Wright Modification of the Schober Test. In a clinical study in which dosages were adjusted according to patient need, sulindac 200 to 400 mg daily was as effective as indomethacin 75 to 150 mg daily. In a second study, sulindac 300 to 400 mg daily was comparable in effectiveness to phenylbutazone 400 to 600 mg daily. ...
Bioline International Official Site (site up-dated regularly)Bioline International Official Site (site up-dated regularly)
In this study we evaluated the analgesic and anti-inflammatory activities of the methanol extract of stem bark of Diospyros cordifolia (MEDC) Roxb. The analgesic effects of the stem bark of the plant was assessed in mice using the tail-flick method while carrageenan, histamine and dextran induced paw oedema was used to study the antiinflammatory effects in rats. The MEDC exhibited significant (p 0.01) analgesic effects comparable to the reference drug diclofenac sodium. MEDC also was evaluated for its anti-inflammatory potential against carrageenan, histamine and dextran induced rat paw edema. The methanol extract (25 and 50 mg / kg body weight) exhibited significant (p < 0.01) activity against all phlogistic agents used in a dose dependent manner. All these effects were compared with reference drug phenylbutazone (100 mg/kg body weight ...
Humulin N Inj 100u/mlHumulin N Inj 100u/ml
What should I avoid while giving Humulin to my pet: Notify your veterinarian of any other medications, including vitamins and supplements, your pet is taking while your pet is receiving Insulin. Increased risk of low blood sugar may occur if used with anabolic steroids, beta-blockers, monoamine oxidase inhibitors, phenylbutazone, sulfinpyrasone, tetracycline, or salicylates like aspirin. Increased risk of high blood sugar may occur if used with glucocorticoids, thyroid medications, dobutamine, epinephrine, estrogen/ progesterone combinations, or diuretics. Hypoglycemic agents such as glipizide may help lower Insulin requirements, as may chromium picolinate. Use care when starting treatment for thyroid disorders in a diabetic animal, as Insulin needs may change. Changes in potassium levels may occur when using Insulin along with heart medications and/or diuretics ...
Cavalor FreeBute | Equillence LtdCavalor FreeBute | Equillence Ltd
Cavalor FreeBute supports the muscles and joints of horses that have to deliver top performances. It may relieve joints and muscle pain following exercise. This is a doping-free way to provide all the benefits of phenylbutazone without causing stomach irritation.. The relief of pain and discomfort, aimed at giving a horse more rest and comfort, is the start of many healing and recovery processes. However, the means to do so can have unwanted side effects, which may even harm the horse, and/or contain substances that prevent the horse from participating in competitions for some time. For many years it has been known from botany and herbal science that a number of natural nutritional elements which are completely innocuous - and therefore have no harmful side effects and may be used in competitive sports - give relief in many common situations. Based on these insights, Cavalor Free Bute Natural Relief tablets have been developed.. ...
Plus itPlus it
Chronic treatment of rats with drugs and insecticides, such as phenobarbital, chlorcyclizine, phenylbutazone, chlordane and dichlorodiphenyltrichloroethane (DDT), stimulates the in vitro hydroxylation of progesterone and other steroids by liver microsomes and markedly decreases the central depressant effects of administered steroid hormones. The decreased central depressant effect of administered progesterone in phenobarbital-pretreated rats is associated with decreased levels of progesterone and its metabolites in the brain. The ability of liver microsomal enzyme stimulators to decrease the central depressant effects of progesterone raises the possibility that liver microsomal enzyme stimulators may also alter physiologic actions of endogenous steroids in the body.. ...
SAMU MEDIAN CO.,LTD.SAMU MEDIAN CO.,LTD.
BROMㆍA powder is a complex controller of Bromhexine reducing cough and phlegm, Phenylbutazone having action of antipyreticㆍanalgesicㆍantiphlogistic, and Vitamin A giving aid to revival of damaged respiratory epithelial cell, and it shows an efficacy of treatment and prevention of repiratory disease ...
SAMU MEDIAN CO.,LTD.SAMU MEDIAN CO.,LTD.
BROMㆍA powder is a complex controller of Bromhexine reducing cough and phlegm, Phenylbutazone having action of antipyreticㆍanalgesicㆍantiphlogistic, and Vitamin A giving aid to revival of damaged respiratory epithelial cell, and it shows an efficacy of treatment and prevention of repiratory disease ...
Role of foreign trade in economic development of usaRole of foreign trade in economic development of usa
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List of withdrawn drugsList of withdrawn drugs
OxyphenbutazoneOxyphenbutazone
Glossary of North American horse racingGlossary of North American horse racing
HepatotoxicityHepatotoxicity
Exercise-induced pulmonary hemorrhageExercise-induced pulmonary hemorrhage
AloxiprinAloxiprin
Eosinophilic myocarditisEosinophilic myocarditis
Red-headed vultureRed-headed vulture
LaminitisLaminitis
SuxibuzoneSuxibuzone
CarprofenCarprofen
M. VijayanM. Vijayan
Propyphenazone/paracetamol/caffeinePropyphenazone/paracetamol/caffeine
ClofexamideClofexamide
ClofezoneClofezone
KetoprofenKetoprofen
Pigeon feverPigeon fever
Animal euthanasiaAnimal euthanasia
TolmetinTolmetin
ClenbuterolClenbuterol
Equine lymphangitisEquine lymphangitis
GliclazideGliclazide
ParotitisParotitis
Kentucky DerbyKentucky Derby
Bill InmanBill Inman
Purpura haemorrhagicaPurpura haemorrhagica
Dancers ImageDancer's Image
FlunixinFlunixin
Kentucky Derby top four finishersKentucky Derby top four finishers
Meclofenamic acidMeclofenamic acid
OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth CareGeographicals
PhenylbutazoneOxyphenbutazoneKidney Papillary NecrosisPlatelet Factor 3ApazoneNaproxenHorse DiseasesSulfinpyrazoneCalotropisHorsesHypoprothrombinemiasAnti-Inflammatory AgentsElectronic MailFood Dispensers, AutomaticEditorial PoliciesAuthorshipPeriodicals as TopicPostal ServiceInternetCattle DiseasesUnited States Food and Drug AdministrationCattleEquipment SafetyTerminology as TopicSafetyAccidents, OccupationalDatabases, ChemicalAnti-Inflammatory Agents, Non-SteroidalLameness, AnimalVeterinary DrugsEuropean UnionFood SafetyDrug ResiduesPesticide ResiduesPolyneuropathiesAmyloid Neuropathies, FamilialAmyloid NeuropathiesPrealbuminMarketingResearch ReportFoundationsDietetics
Phenylbutazone Added to Prohibited ListPhenylbutazone Added to Prohibited List
phenylbutazone | C19H20N2O2 - PubChemphenylbutazone | C19H20N2O2 - PubChem
Phenylbutazone (Bute) Use in HorsesPhenylbutazone (Bute) Use in Horses
Joint Statement of EFSA and EMA on the presence of residues of phenylbutazone in horse meat | European Food Safety AuthorityJoint Statement of EFSA and EMA on the presence of residues of phenylbutazone in horse meat | European Food Safety Authority
Toxic polyneuropathy -- Phenylbutazone Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.comToxic polyneuropathy -- Phenylbutazone Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com
BUTE Phenylbutazone (Generic) Injectable Solution 20% for Horses, 100-mL - Chewy.comBUTE Phenylbutazone (Generic) Injectable Solution 20% for Horses, 100-mL - Chewy.com
2016 Phenylbutazone (CAS 50-33-9) Industry Market Report - RnR Market Research2016 Phenylbutazone (CAS 50-33-9) Industry Market Report - RnR Market Research
Epicharis Bypasses Training Again at Belmont Park - BloodHorseEpicharis Bypasses Training Again at Belmont Park - BloodHorse
Publication : USDA ARSPublication : USDA ARS
Concern Continues Over Potential Residues in Imported Foods | The Fish SiteConcern Continues Over Potential Residues in Imported Foods | The Fish Site
Newer Anti-Rheumatic Drugs | Annals of Internal Medicine | American College of PhysiciansNewer Anti-Rheumatic Drugs | Annals of Internal Medicine | American College of Physicians
Food Safety Newsletter - FoodHACCP.comFood Safety Newsletter - FoodHACCP.com
Phenylbutazone-induced pericarditis. | The BMJPhenylbutazone-induced pericarditis. | The BMJ
Phenylbutazone - WikipediaPhenylbutazone - Wikipedia
Aplastic Anaemia Due to Phenylbutazone | The BMJAplastic Anaemia Due to Phenylbutazone | The BMJ
phenylbutazone, Butazolidine: Drug Facts, Side Effects and Dosingphenylbutazone, Butazolidine: Drug Facts, Side Effects and Dosing
Phenylbutazone for Horses - NSAID for Pain - 1800PetMedsPhenylbutazone for Horses - NSAID for Pain - 1800PetMeds
phenylbutazone - Infinite Unknownphenylbutazone - Infinite Unknown
Ticinil Calcico (Phenylbutazone Calcium) Boehringer IngelheimTicinil Calcico (Phenylbutazone Calcium) Boehringer Ingelheim
Ambene (Dexamethasone; Lidocaine Hydrochloride; Phenylbutazone Sodium...) RatiopharmAmbene (Dexamethasone; Lidocaine Hydrochloride; Phenylbutazone Sodium...) Ratiopharm
Brazil Phenylbutazone Calcium Monthly Import Data MonitoringBrazil Phenylbutazone Calcium Monthly Import Data Monitoring
Hemoperfusion for Phenylbutazone Poisoning | Annals of Internal Medicine | American College of PhysiciansHemoperfusion for Phenylbutazone Poisoning | Annals of Internal Medicine | American College of Physicians
Retardation of ossification of the lumbar vertebral column in ankylosing spondylitis by means of phenylbutazone. - PubMed -...Retardation of ossification of the lumbar vertebral column in ankylosing spondylitis by means of phenylbutazone. - PubMed -...
Phenylbutazone in the treatment of Tietzes syndrome. | Annals of the Rheumatic DiseasesPhenylbutazone in the treatment of Tietze's syndrome. | Annals of the Rheumatic Diseases
Phenylbutazone medication - Answers on HealthTapPhenylbutazone medication - Answers on HealthTap
Detection of Phenylbutazone in Race HorsesDetection of Phenylbutazone in Race Horses
Inflammation Medication for Horses - Phenylbutazone/Cimetidine Oral PowderInflammation Medication for Horses - Phenylbutazone/Cimetidine Oral Powder
Initial Solvent Screening of Carbamazepine, Cimetidine, and Phenylbutazone: Part 1 of 2 | Pharmaceutical TechnologyInitial Solvent Screening of Carbamazepine, Cimetidine, and Phenylbutazone: Part 1 of 2 | Pharmaceutical Technology
Butatron Phenylbutazone for Horses Bimeda - Safe.Pharmacy|Inflammation Pain (Rx) | Equine Pharmacy (Butatron Phenylbutazone for Horses Bimeda - Safe.Pharmacy|Inflammation Pain (Rx) | Equine Pharmacy (
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Phenylbutazone | elephantcarePhenylbutazone | elephantcare
Preclinical screening of Antiulcer activity of Asparagus racemosus extract on phenylbutazone induced ulceration in experimental...Preclinical screening of Antiulcer activity of Asparagus racemosus extract on phenylbutazone induced ulceration in experimental...
VetriBute PhenylbutazoneVetriBute Phenylbutazone
Phenylbutazone Side Effects - DrugInformerPhenylbutazone Side Effects - DrugInformer
Phenylbutazone, USP | Encore ScientificPhenylbutazone, USP | Encore Scientific
phenylbutazone | Tabers Medical Dictionaryphenylbutazone | Taber's Medical Dictionary
OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth CareGeographicals
PhenylbutazoneOxyphenbutazoneKidney Papillary NecrosisPlatelet Factor 3ApazoneNaproxenHorse DiseasesSulfinpyrazoneCalotropisHorsesHypoprothrombinemiasAnti-Inflammatory AgentsElectronic MailFood Dispensers, AutomaticEditorial PoliciesAuthorshipPeriodicals as TopicPostal ServiceInternetCattle DiseasesUnited States Food and Drug AdministrationCattleEquipment SafetyTerminology as TopicSafetyAccidents, OccupationalDatabases, ChemicalAnti-Inflammatory Agents, Non-SteroidalLameness, AnimalVeterinary DrugsEuropean UnionFood SafetyDrug ResiduesPesticide ResiduesPolyneuropathiesAmyloid Neuropathies, FamilialAmyloid NeuropathiesPrealbuminMarketingResearch ReportFoundationsDietetics
ButeHorsemeatHorsesCortisoneExposureLamenessDosageCattleMeatPresentAgentButeHalf-life of phenylbutazoneSide effects of phenylbutazoneContains 1 gramNSAIDsResidues of phenylbutazoneNSAIDAnkylosing spondylitisAnti-inflammatoryOral phenylbutazoneDrug PhenylbutazoneGramButazolidinOrallyMetabolismVeterinaryMedication2017Micrograms per millilSymptomsSodiumHorse meatButazolidineGastricMetabolitesPrecautionsIntravenouslyOccurMedicationsCimetidinePowderUlcersDrugsHumansOverdoseSubstanceConcentrationOsteoarthritisPharmacokineticsEliminationBone marrowAssessmentTissue
Bute6
Horsemeat1
Horses2
Cortisone2
Exposure2
Lameness1
  • For the third consecutive day, Belmont Stakes Presented by NYRA Bets (G1) entrant Epicharis did not go to the track June 9, two days after he received a treatment of phenylbutazone for 'lameness' in his right front leg. (bloodhorse.com)
Dosage1
Cattle3
  • No withdrawal period has been established for phenylbutazone and no marker compound or tissue exists for PBZ in cattle. (usda.gov)
  • Parent phenylbutazone was the major excretory product in cattle urine. (usda.gov)
  • One sample of cattle live was found to contain phenylbutazone. (thefishsite.com)
Meat1
  • This work by Creme Global has uncovered results which are crucial to our understanding of the current situation and even more important for future scenarios and developments as more test results emerge on meat products across Europe (in particular the tests for Phenylbutazone). (cremeglobal.com)
Present1
Agent1
Bute9
Half-life of phenylbutazone2
Side effects of phenylbutazone4
Contains 1 gram2
NSAIDs4
Residues of phenylbutazone2
  • Following the request from the European Commission, the European Medicines Agency and the European Food Safety Authority jointly concluded on the risk assessment on residues of phenylbutazone in horse meat in the context of recent fraudulent practices. (europa.eu)
  • The pharmacokinetics, metabolism, excretion and tissue residues of phenylbutazone (PBZ) in the horse were studied following both intravenous and oral administration of the drug at a dose rate of 4.4 mg/kg. (ac.ke)
NSAID5
Ankylosing spondylitis4
Anti-inflammatory4
Oral phenylbutazone2
Drug Phenylbutazone1
Gram1
Butazolidin1
Orally5
  • Phenylbutazone can be administered orally (via paste, powder or feed-in) or intravenously. (wikipedia.org)
  • a single administration of 3 g intravenously, or - a 3-g intravenous dose, once daily for 3 days or - a single administration of 3 g orally or - a 3-g oral dose once daily for three days, the concentration of phenylbutazone was shown to decrease below detection level 96 hours after the last treatment. (gov.on.ca)
  • Animals were induced for gastric ulcer with Phenylbutazone (100mg/kg bodyweight) and treated orally with ARE (250 and 500 mg/kg bodyweight). (plantsjournal.com)
  • Phenylbutazone may be given orally or by the intravenous route. (stablemade.com)
  • When giving phenylbutazone orally, follow instructions for proper administration of gel or paste forms. (stablemade.com)
Metabolism2
Veterinary2
  • The Committee for Veterinary Medicinal Products assessed the consumer safety for phenylbutazone in 1997 and identified the main risks for the consumer as idiosyncratic blood dyscrasias and the genotoxic/carcinogenic potential for which no thresholds could be identified and no maximum residue limits could be established. (europa.eu)
  • Measures proposed to further minimise the risk include strengthening of the horse passport system, harmonised monitoring of phenylbutazone and its main metabolite and better reporting of monitoring of veterinary drug residues and other substances across the EU. (europa.eu)
Medication2
20171
  • 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/766552/all/phenylbutazone. (unboundmedicine.com)
Micrograms per millil2
Symptoms2
  • More detailed information about the symptoms , causes , and treatments of Toxic polyneuropathy -- Phenylbutazone is available below. (rightdiagnosis.com)
  • Below are symptoms of a phenylbutazone overdose in different parts of the body. (medlineplus.gov)
Sodium4
  • Phenylbutazone Sodium. (drugs-about.com)
  • Phenylbutazone may cause decreased blood flow to the kidneys and result in sodium and water retention. (gov.on.ca)
  • It is supplied with each mL containing 200 mg of phenylbutazone, 10.45 mg of benzyl alcohol as preservative, sodium hydroxide to adjust pH to 9.5 to 10.0, and water for injection, Q.S. (chewy.com)
  • Phenylbutazone may cause decreased renal blood flow and sodium and water retention, and should be used cautiously in animals with preexisting renal disease or CHF. (elephantcare.org)
Horse meat3
  • Positive phenylbutazone tests in horse meat were uncommon in the UK, however. (wikipedia.org)
  • Exposure to phenylbutazone from horse meat consumed as such or present in beef-based products was assessed on the basis of limited monitoring data provided by 19 Member States and of conservative assumptions. (europa.eu)
  • The risk of carcinogenicity to humans from exposure was considered very low based on the available experimental data on organ toxicity and carcinogenicity, as well as on the low exposure levels and the infrequent exposure to phenylbutazone from horse meat or adulterated beef-based products. (europa.eu)
Butazolidine1
  • Phenylbutazone (Butazolidine) is no longer available in the United States. (medicinenet.com)
Gastric1
  • The present study aimed to evaluate the effect of 50% ethanolic extract of Asparagus racemosus whole plant extract (ARE) on Phenylbutazone induced chronic gastric damage in experimental rats. (plantsjournal.com)
Metabolites1
  • Phenylbutazone and its metabolites are included in the list of drugs in the Drug Surveillance Program of the Canadian Pari-Mutuel Agency (CPMA), which regulates the Canadian racehorse industry. (gov.on.ca)
Precautions1
  • Contraindications/Precautions - Phenylbutazone is contraindicated in patients with a his-tory of, or preexisting hematologic or bone marrow abnormalities, preexisting GI ulcers, and in food producing animals or lactating dairy cattle. (elephantcare.org)
Intravenously1
Occur1
Medications1
  • Phenylbutazone is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin ( Coumadin ), because of an increased risk of bleeding. (medicinenet.com)
Cimetidine1
Powder1
  • Chemistry - A synthetic pyrazolone derivative related chemically to aminopyrine, phenylbutazone occurs as a white to off-white, odorless crystalline powder that has a pK a of 4.5. (elephantcare.org)
Ulcers1
  • Adverse Effects/Warnings - The primary concerns with phenylbutazone therapy in hu-mans include its bone marrow effects (agranulocytosis, aplastic anemia), renal and cardio-vascular effects (fluid retention to acute renal failure), and GI effects (dyspepsia to perfo-rated ulcers). (elephantcare.org)
Drugs5
  • Phenylbutazone has been removed from the United States market due to the availability of newer drugs with less adverse effects. (medicinenet.com)
  • Which drugs or supplements interact with phenylbutazone? (medicinenet.com)
  • Effective May 29, 2003, the Food and Drug Administration (FDA) will prohibit extralabel use of phenylbutazone animal and human drugs in female dairy cattle 20 months of age or older. (usu.edu)
  • As with most drugs Phenylbutazone has legal uses and also illegal uses. (ukessays.com)
  • Phenylbutazone is contraindicated in patients demonstrating previous hypersensitivity re-actions to it, and should be used very cautiously in patients that have a history of allergies to other drugs. (elephantcare.org)
Humans2
  • Phenylbutazone was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in 1949. (wikipedia.org)
  • The FDA is issuing the order based on evidence that extralabel use of phenylbutazone in female dairy cattle 20 months of age or older will likely cause an adverse event in humans. (usu.edu)
Overdose1
Substance1
  • Phenylbutazone has been rescheduled as a Schedule 7 substance (previously a Schedule 6 medicine) and consequently declared a prohibited substance, effective as from 8 May 2014, the date of publication of the Amendment to the Schedules (including Schedule 7) published in terms of section 22A of Act 101 of 1965 in Government Gazette Number 37622 under Notice Number R352. (savc.org.za)
Concentration1
Osteoarthritis1
  • Phenylbutazone is occasionally used in dogs for the longer-term management of chronic pain, particularly due to osteoarthritis. (wikipedia.org)
Pharmacokinetics1
  • Pharmacokinetics - Following oral administration, phenylbutazone is absorbed from both the stomach and small intestine. (elephantcare.org)
Elimination1
  • Phenylbutazone has a plasma elimination half-life of 4-8 hours, however the inflammatory exudate half life is 24 hours, so single daily dosing can be sufficient, although it is often used twice per day. (wikipedia.org)
Bone marrow1
  • However, because of a unique risk of bone marrow suppression (causing dangerously low white blood counts), phenylbutazone is generally reserved only for short-term use in selected patients. (medicinenet.com)
Assessment2
  • Phenylbutazone significantly improved morning stiffness, finger-to-floor distance, chest expansion, overall joint pain, spinal pain, the physician's assessment of disease activity and ESR. (ox.ac.uk)
  • Published in silico , in vitro , in vivo laboratory animal and human data, together with information on biotransformation and data from structure-activity analyses with two decision-tree systems (ACToR and Toxtree), have been used in a weight-of-evidence (WoE) assessment to determine whether phenylbutazone (PBZ) is a genotoxic or a non-genotoxic carcinogen. (atla.org.uk)
Tissue2
  • Phenylbutazone is extremely irritating to tissues and can cause extensive swelling, pain, tissue damage, and even loss of tissues if injected outside the vein. (stablemade.com)
  • No withdrawal period has been established for phenylbutazone and no marker compound or tissue exists for PBZ in cattle. (usda.gov)
BUTE Phenylbutazone (Generic) Injectable Solution 20% for Horses, 100-mL - Chewy.com
BUTE Phenylbutazone (Generic) Injectable Solution 20% for Horses, 100-mL - Chewy.com (chewy.com)
Comparing Bute and Firocoxib Safety (AAEP 2010) - BloodHorse
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Toxic polyneuropathy -- Phenylbutazone Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com
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