A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27)
A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAILURE.
A phospholipid from the platelet membrane that contributes to the blood clotting cascade by forming a phospholipid-protein complex (THROMBOPLASTIN) which serves as a cofactor with FACTOR VIIA to activate FACTOR X in the extrinsic pathway of BLOOD COAGULATION.
An anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout.
An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.
Diseases of domestic and wild horses of the species Equus caballus.
A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
A plant genus of the family ASCLEPIADACEAE. The downy akund floss fiber from the seeds is used like kapok.
Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.
Absence or reduced levels of PROTHROMBIN in the blood.
Substances that reduce or suppress INFLAMMATION.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.
The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.
The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.
A group of disorders having a benign course but exhibiting clinical and histological features suggestive of malignant lymphoma. Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. (From Dorland, 28th ed & Stedman, 26th ed)
Rare skin eruption characterized by acute formation of pustules filled with NEUTROPHILS, fever, and peripheral blood LEUKOCYTOSIS. Most cases are associated with the use of antibiotics (e.g., BETA-LACTAMS).
Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.
This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.
Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)
'Skin diseases' is a broad term for various conditions affecting the skin, including inflammatory disorders, infections, benign and malignant tumors, congenital abnormalities, and degenerative diseases, which can cause symptoms such as rashes, discoloration, eruptions, lesions, itching, or pain.

Racing problems in the U.S.A. (1/149)

The major problems of racing in the United States at the present time are caused by too much racing. This has led to too few horses and small fields. Consequently many owners and trainers are trying to enter their horses too frequently and to race them when they are not really fit to run. The desire to race horses as frequently as possible has led to constant pressure from horsemen through their organizations for so called "permissive medication". Started in the state of Colorado approximately ten years ago this has grown until finally there are only a few states, notably New York and New Jersey that have resisted the pressure. The drug that gave the opening wedge to permissive medication was phenylbutazone, but this in many states has led to the inclusion of other drugs including analgesics and drugs that veterinarians claim are needed for therapeutic purposes. Some states have endeavoured to control phenylbutazone medication by quantitation and while lower limits cause little difficulty, maximum allowable limits have caused problems and are not practical. While there has been no publicity to my knowledge about frusemide (furosemide, lasix) the abuse of this drug for so called "bleeders" is an example that may seriously interfere with drug detection in urine and its use should be confined to proven "bleeders" (i.e. horses suffering from epistaxis). Pre-race blood testing began roughly ten years ago at the harness tracks and has been resisted by our flat tracks rather successfully up to the present time. The blood testing methods and those used by the same laboratories in post-race urine testing is inadequate and will not detect many illegal drugs.  (+info)

Anti-ulcer effects of 4'-(2-carboxyetyl) phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride (cetraxate) on various experimental gastric ulcers in rats. (2/149)

Anti-ulcer effects of cetraxate, a new compound possessing anti-plasmin, anti-casein and anti-trypsin actions were investigated by using experimental gastric ulcer models in rats. Cetraxate, 300 mg/kg p.o. showed significant inhibitory effects of 65.3%, 70.0%, 30.2%, and 67.1% against aucte types of ulcers producing by aspirin, phenylbutazone, indomethacin, and pyloric ligature (Shay's ulcer), respectively. These effects were greater than those obtained by gefarnate and aluminum sucrose sulfate may be mainly attributed to the protecting action of this drug on gastric mucosa. Ctraxate further revealed remarkable inhibitory effects on chronic types of ulcers produced by acetic acid, clamping, and clamping-cortisone. In acetic acid ulcer in particular, cetraxate was found to have a dose-dependent inhibitory effect at doses over 50 mg/kg. Of test drugs including L-glutamine and methylmethionine sulfonium chloride, cetraxate showed the most remarkable inhibitory effect on beta-glucuronidase activity in ulcer tissue of these three types of ulcers. These findings suggest that cetraxate may prevent the connective tissue in the ulcer location from decomposition due to lysosomal enzymes such as beta-glucuronidase, thereby accelerating the recovery from ulcer.  (+info)

The effect of streptomycin, oxytetracycline, tilmicosin and phenylbutazone on spermatogenesis in bulls. (3/149)

To determine whether declining semen quality associated with health problems may be due to certain antibiotic or anti-inflammatory treatments, semen was collected 3 times per week for up to 42 d from 6 normal bulls after treatment with oxytetracycline, tilmicosin, dihydrostreptomycin, or phenylbutazone. No adverse effects on semen quality were observed.  (+info)

Antinative DNA antibodies as a reaction to pyrazole drugs. (4/149)

A case history is presented of the occurrence of a high binding capacity for native DNA in the serum of a patient on phenylbutazone. This reverted to normal on stopping the drug. The patient also had a reversible neutropenia and leucopenia, and it is suggested that the high anti-DNA binding capacity was a feature of a drug-induced lupus-like phenomenon.  (+info)

Effect of 1-(m-chlorophenyl)-3-N,N-dimethyl-carbamoyl-5-methoxypyrazole (PZ-177) on drug-metabolizing enzyme on rat liver. (5/149)

Effect of 1-(m-chlorphenyl)-3-N,N-dimethylcarbamoyl-5-methoxypyrazole (PZ-177) (62.5 and 250 mg/kg) on rat liver was investigated by measuring liver weight and drug-metabolizing enzyme activity. The effects of PZ-177 were compared with those of phenobarbital, phenylbutazone, and tiaramide hydrochloride. Increase of liver weight and liver/body weight ratio was observed in the rats treated with PZ-177 or phenobarbital, however, normal values were reverted to 1--2 weeks after treatment. PZ-177 similar to phenobarbital, significantly enhanced the activity of aminopyrine demethylase and aniline hydroxylase after 1,2, and 4 weeks of treatment. In contrast, tiaramide hydrochloride decreased the activity of aminopyrine demethylase and aniline hydroxylase after 1 week of treatment, and significantly enhanced the activity of these enzymes after 4 weeks. The content of cytochrome P-450 and the activity of NADPH cytochrome C reductase were also increased by treatment with PZ-177. The sleeping time by hexobarbital was shortened significantly by the administration of PZ-177. Vmax for both aminopyrine demethylase and aniline hydroxylase increased by treatment with PZ-177. However, only the Km for aniline hydroxylase was increased by treatment with PZ-177. From the results of these experiments, PZ-177 may be classified as a phenobarbital-type inducer.  (+info)

Feprazone, a new anti-inflammatory agent. Studies of potency and gastrointestinal tolerance. (6/149)

Two studies are reported; a double-blind cross-over trial of feprazone 600 mg daily and aspirin 3.6 g daily in the treatment of rheumatoid arthritis, and an uncontrolled open study of gastrointestinal tolerance in twenty rheumatoid arthritis patients with known intolerance to other drugs. The first study showed that feprazone was significantly superior to aspirin in all the parameters tested. In the second study all twenty patients showed an improvement of their gastrointestinal symptoms, nineteen reporting no symptoms at all when taking the new preparation.  (+info)

Reiter's disease in three boys. (7/149)

Three cases of Reiter's disease occurring in boys under the age of 16 are reported. One of these presented with a Salmonella enteritidis diarrhoea. This conforms to the 'dysenteric' form of Reiter's disease usually seen in Europe and rarely reported in England. Another presented with a monarticular arthritis of the knee, and the third has developed a chronic relapsing erosive arthritis as a result of sexually acquired Reiter's disease--an occurrence not previously reported in this age group. We draw attention to the frequency of diarrhoea in these children and the sex incidence of 1 female to 4--5 males, which agrees more with Reiter's disease of dysenteric origin than that acquired venereally.  (+info)

Molecular characteristics of the inhibition of human neutrophil elastase by nonsteroidal antiinflammatory drugs. (8/149)

Nonsteroidal antiinflammatory drugs(NSAIDs) are known as clinically effective agents for treatment of inflammatory diseases. Inhibition of cyclooxygenase has been thought to be a major facet of the pharmacological mechanism of NSAIDs. However, it is difficult to ascribe the antiinflammatory effects of NSAIDs solely to the inhibition of prostaglandin synthesis. Human neutrophil elastase (HNElastase; HNE, EC 3.4.21.37) has been known as a causative factor in inflammatory diseases. To investigate the specific relationship between HNElastase inhibition and specificity of molecular structure of several NSAIDs, HNElastase was purified by Ultrogel AcA54 gel filtration, CM-Sephadex ion exchange, and HPLC (with TSK 250 column) chromatography. HNElastase was inhibited by aspirin and salicylate in a competitive manner and by naproxen, ketoprofen, phenylbutazone, and oxyphenbutazone in a partial competative manner, but not by ibuprofen and tolmetin. HNElastase-phenylbutazone-complex showed strong Raman shifts at 200, 440, 1124, 1194, 1384, 1506, and 1768 cm(-1). The Raman bands 1194, 1384, and 1768 cm(-1) may represent evidences of the conformational change at -N=N-phi radical, pyrazol ring, and -C=O radical of the elastase-drug complex, respectively. Phenylbutazone might be bound to HNElastase by ionic and hydrophobic interaction, and masked the active site. Inhibition of HNElastase could be another mechanism of action of NSAIDs besides cyclooxygenase inhibition in the treatment of inflammatory diseases. Different inhibition characteristics of HNE-lastase by NSAIDs such as aspirin, phenylbutazone-like drugs and ineffective drugs could be important points for drawing the criteria for appropriate drugs in clinical application.  (+info)

Phenylbutazone is a non-steroidal anti-inflammatory drug (NSAID) that was commonly used in the past to treat pain and inflammation associated with conditions such as rheumatoid arthritis, osteoarthritis, and gout. It works by inhibiting the activity of cyclooxygenase (COX) enzymes, which are involved in the production of prostaglandins, chemicals that mediate inflammation and pain.

However, due to its potential for serious side effects, including bone marrow suppression, liver toxicity, and increased risk of heart attack and stroke, phenylbutazone is no longer commonly used in human medicine in many countries, including the United States. It may still be used in veterinary medicine under strict supervision.

Oxyphenbutazone is a non-selective non-steroidal anti-inflammatory drug (NSAID) that has been used in the past for its analgesic, anti-inflammatory, and antipyretic properties. It works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the synthesis of prostaglandins, chemicals that mediate inflammation, pain, and fever.

However, due to its potential for serious side effects such as gastrointestinal ulcers, bleeding, and kidney damage, as well as interactions with other medications, oxyphenbutazone is no longer commonly used in many countries. It has been largely replaced by newer NSAIDs that have a more favorable safety profile.

It's important to note that the use of oxyphenbutazone should be under the strict supervision of a healthcare professional and should only be taken as directed, as it can cause potentially serious side effects even at therapeutic doses.

Kidney papillary necrosis is a medical condition characterized by the death (necrosis) of the renal papillae, which are the small conical projections at the ends of the renal tubules in the kidneys. This condition typically occurs due to reduced blood flow to the kidneys or as a result of toxic injury from certain medications, chronic infections, diabetes, sickle cell disease, and systemic vasculitides.

The necrosis of the papillae can lead to the formation of small stones or debris that can obstruct the flow of urine, causing further damage to the kidneys. Symptoms of kidney papillary necrosis may include fever, flank pain, nausea, vomiting, and bloody or foul-smelling urine. The diagnosis is typically made through imaging studies such as CT scans or MRI, and treatment may involve addressing the underlying cause, administering antibiotics to prevent infection, and providing supportive care to maintain kidney function.

Platelet Factor 3 (PF3) is not a separate protein entity but rather refers to the complex formed when platelets are activated and expose their inner membrane, specifically a phospholipid-rich granule called the granule membrane particle, to the outside. This complex of platelet membrane with coagulation factors then serves as a catalytic surface for the acceleration of thrombin formation in the coagulation cascade.

In other words, PF3 is a part of the activated platelet's surface that plays an important role in blood clotting by promoting the conversion of prothrombin to thrombin and the subsequent fibrin formation, which helps to strengthen the clot.

I'm sorry for any confusion, but "Apazone" is not a term recognized in medical terminology. It may be a proper name of a compound or medication from a specific company or context, but without more information, I cannot provide an accurate definition or meaning. In general, it's important to use precise and unambiguous language when discussing medical topics to ensure clear communication and understanding.

Naproxen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for its analgesic (pain-relieving), antipyretic (fever-reducing), and anti-inflammatory properties. It works by inhibiting the enzyme cyclooxygenase, which leads to reduced prostaglandin production, thereby alleviating pain, inflammation, and fever.

Medical professionals prescribe Naproxen for various conditions such as:

1. Pain management: Naproxen can be used to treat mild to moderate pain caused by conditions like headaches, menstrual cramps, muscle aches, and dental issues.
2. Inflammatory conditions: It is effective in reducing inflammation associated with arthritis (osteoarthritis, rheumatoid arthritis, and juvenile arthritis), gout, bursitis, and tendonitis.
3. Fever reduction: Naproxen can help lower fever caused by infections or other medical conditions.

Common side effects of Naproxen include stomach upset, heartburn, nausea, dizziness, and headaches. Serious side effects, although rare, may include gastrointestinal bleeding, kidney damage, and increased risk of cardiovascular events (e.g., heart attack or stroke). Patients should consult their healthcare provider for appropriate dosage and potential risks before starting Naproxen therapy.

I understand you are asking for a medical definition of "Horse Diseases." However, it's important to note that there isn't a specific medical field dedicated to horse diseases as we typically categorize medical fields by human diseases and conditions. Veterinary medicine is the field responsible for studying, diagnosing, and treating diseases in animals, including horses.

Here's a general definition of 'Horse Diseases':

Horse diseases are health issues or medical conditions that affect equine species, particularly horses. These diseases can be caused by various factors such as bacterial, viral, fungal, or parasitic infections; genetic predispositions; environmental factors; and metabolic disorders. Examples of horse diseases include Strangles (Streptococcus equi), Equine Influenza, Equine Herpesvirus, West Nile Virus, Rabies, Potomac Horse Fever, Lyme Disease, and internal or external parasites like worms and ticks. Additionally, horses can suffer from musculoskeletal disorders such as arthritis, laminitis, and various injuries. Regular veterinary care, preventative measures, and proper management are crucial for maintaining horse health and preventing diseases.

Sulfinpyrazone is a medication that belongs to the class of drugs known as uricosurics. It works by increasing the amount of uric acid that is removed from the body through urine, which helps to lower the levels of uric acid in the blood. This makes it useful for the treatment of conditions such as gout and kidney stones that are caused by high levels of uric acid.

In addition to its uricosuric effects, sulfinpyrazone also has antiplatelet properties, which means that it can help to prevent blood clots from forming. This makes it useful for the prevention of heart attacks and strokes in people who are at risk.

Sulfinpyrazone is available by prescription and is typically taken by mouth in the form of tablets. It may be used alone or in combination with other medications, depending on the individual patient's needs and medical condition. As with any medication, sulfinpyrazone should be used under the supervision of a healthcare provider, and patients should follow their provider's instructions carefully to ensure safe and effective use.

'Calotropis' is a genus of flowering plants in the family Apocynaceae, also known as milkweeds or crownflowers. There are two main species within this genus: Calotropis procera and Calotropis gigantea. These plants are native to tropical and subtropical regions of Africa, Asia, and Australia. They have large, showy flowers and produce a milky sap that contains latex. Some parts of these plants, such as the roots and leaves, have been used in traditional medicine for various purposes, including treating skin conditions, inflammation, and pain. However, it is important to note that all parts of Calotropis plants contain toxic compounds and can cause serious side effects if ingested or applied improperly. Therefore, they should only be used under the guidance of a qualified healthcare professional.

I'm sorry for any confusion, but "horses" is not a medical term. It is the common name given to the species *Equus ferus caballus*, which are large domesticated mammals used for transportation, work, and recreation. If you have any questions about horses or a related topic that you would like a medical perspective on, please let me know and I'd be happy to help!

Hypoprothrombinemia is a medical condition characterized by a decreased level of prothrombin (coagulation factor II) in the blood, which can lead to an increased bleeding tendency. Prothrombin is a protein involved in the coagulation cascade that helps to form blood clots and stop bleeding.

Hypoprothrombinemia can be caused by various factors, including vitamin K deficiency, liver disease, inherited or acquired disorders of prothrombin synthesis, or the use of certain medications such as warfarin. Symptoms may include easy bruising, prolonged bleeding from cuts or injuries, nosebleeds, and in severe cases, internal bleeding. Treatment typically involves addressing the underlying cause and may include vitamin K supplementation, fresh frozen plasma transfusions, or other specific therapies depending on the etiology of the condition.

Anti-inflammatory agents are a class of drugs or substances that reduce inflammation in the body. They work by inhibiting the production of inflammatory mediators, such as prostaglandins and leukotrienes, which are released during an immune response and contribute to symptoms like pain, swelling, redness, and warmth.

There are two main types of anti-inflammatory agents: steroidal and nonsteroidal. Steroidal anti-inflammatory drugs (SAIDs) include corticosteroids, which mimic the effects of hormones produced by the adrenal gland. Nonsteroidal anti-inflammatory drugs (NSAIDs) are a larger group that includes both prescription and over-the-counter medications, such as aspirin, ibuprofen, naproxen, and celecoxib.

While both types of anti-inflammatory agents can be effective in reducing inflammation and relieving symptoms, they differ in their mechanisms of action, side effects, and potential risks. Long-term use of NSAIDs, for example, can increase the risk of gastrointestinal bleeding, kidney damage, and cardiovascular events. Corticosteroids can have significant side effects as well, particularly with long-term use, including weight gain, mood changes, and increased susceptibility to infections.

It's important to use anti-inflammatory agents only as directed by a healthcare provider, and to be aware of potential risks and interactions with other medications or health conditions.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Platelet aggregation inhibitors are a class of medications that prevent platelets (small blood cells involved in clotting) from sticking together and forming a clot. These drugs work by interfering with the ability of platelets to adhere to each other and to the damaged vessel wall, thereby reducing the risk of thrombosis (blood clot formation).

Platelet aggregation inhibitors are often prescribed for people who have an increased risk of developing blood clots due to various medical conditions such as atrial fibrillation, coronary artery disease, peripheral artery disease, stroke, or a history of heart attack. They may also be used in patients undergoing certain medical procedures, such as angioplasty and stenting, to prevent blood clot formation in the stents.

Examples of platelet aggregation inhibitors include:

1. Aspirin: A nonsteroidal anti-inflammatory drug (NSAID) that irreversibly inhibits the enzyme cyclooxygenase, which is involved in platelet activation and aggregation.
2. Clopidogrel (Plavix): A P2Y12 receptor antagonist that selectively blocks ADP-induced platelet activation and aggregation.
3. Prasugrel (Effient): A third-generation thienopyridine P2Y12 receptor antagonist, similar to clopidogrel but with faster onset and greater potency.
4. Ticagrelor (Brilinta): A direct-acting P2Y12 receptor antagonist that does not require metabolic activation and has a reversible binding profile.
5. Dipyridamole (Persantine): An antiplatelet agent that inhibits platelet aggregation by increasing cyclic adenosine monophosphate (cAMP) levels in platelets, which leads to decreased platelet reactivity.
6. Iloprost (Ventavis): A prostacyclin analogue that inhibits platelet aggregation and causes vasodilation, often used in the treatment of pulmonary arterial hypertension.
7. Cilostazol (Pletal): A phosphodiesterase III inhibitor that increases cAMP levels in platelets, leading to decreased platelet activation and aggregation, as well as vasodilation.
8. Ticlopidine (Ticlid): An older P2Y12 receptor antagonist with a slower onset of action and more frequent side effects compared to clopidogrel or prasugrel.

Aspirin is the common name for acetylsalicylic acid, which is a medication used to relieve pain, reduce inflammation, and lower fever. It works by inhibiting the activity of an enzyme called cyclooxygenase (COX), which is involved in the production of prostaglandins, hormone-like substances that cause inflammation and pain. Aspirin also has an antiplatelet effect, which means it can help prevent blood clots from forming. This makes it useful for preventing heart attacks and strokes.

Aspirin is available over-the-counter in various forms, including tablets, capsules, and chewable tablets. It is also available in prescription strengths for certain medical conditions. As with any medication, aspirin should be taken as directed by a healthcare provider, and its use should be avoided in children and teenagers with viral infections due to the risk of Reye's syndrome, a rare but serious condition that can affect the liver and brain.

The placebo effect is a psychological or psychophysiological phenomenon in which a person's symptoms improve following a treatment but this improvement is not attributable to the properties of the treatment itself. Instead, it is believed to be due to the mind's belief in the effectiveness of the treatment, often influenced by positive expectations and the ritualistic aspects of the therapy itself.

Placebos are often used in clinical trials as a control group to compare against the actual treatment. The placebo effect can make it challenging to determine whether an observed improvement is truly due to the treatment or other factors.

The duodenum is the first part of the small intestine, immediately following the stomach. It is a C-shaped structure that is about 10-12 inches long and is responsible for continuing the digestion process that begins in the stomach. The duodenum receives partially digested food from the stomach through the pyloric valve and mixes it with digestive enzymes and bile produced by the pancreas and liver, respectively. These enzymes help break down proteins, fats, and carbohydrates into smaller molecules, allowing for efficient absorption in the remaining sections of the small intestine.

Platelet aggregation is the clumping together of platelets (thrombocytes) in the blood, which is an essential step in the process of hemostasis (the stopping of bleeding) after injury to a blood vessel. When the inner lining of a blood vessel is damaged, exposure of subendothelial collagen and tissue factor triggers platelet activation. Activated platelets change shape, become sticky, and release the contents of their granules, which include ADP (adenosine diphosphate).

ADP then acts as a chemical mediator to attract and bind additional platelets to the site of injury, leading to platelet aggregation. This forms a plug that seals the damaged vessel and prevents further blood loss. Platelet aggregation is also a crucial component in the formation of blood clots (thrombosis) within blood vessels, which can have pathological consequences such as heart attacks and strokes if they obstruct blood flow to vital organs.

Coronary artery bypass surgery, also known as coronary artery bypass grafting (CABG), is a surgical procedure used to improve blood flow to the heart in patients with severe coronary artery disease. This condition occurs when the coronary arteries, which supply oxygen-rich blood to the heart muscle, become narrowed or blocked due to the buildup of fatty deposits, called plaques.

During CABG surgery, a healthy blood vessel from another part of the body is grafted, or attached, to the coronary artery, creating a new pathway for oxygen-rich blood to flow around the blocked or narrowed portion of the artery and reach the heart muscle. This bypass helps to restore normal blood flow and reduce the risk of angina (chest pain), shortness of breath, and other symptoms associated with coronary artery disease.

There are different types of CABG surgery, including traditional on-pump CABG, off-pump CABG, and minimally invasive CABG. The choice of procedure depends on various factors, such as the patient's overall health, the number and location of blocked arteries, and the presence of other medical conditions.

It is important to note that while CABG surgery can significantly improve symptoms and quality of life in patients with severe coronary artery disease, it does not cure the underlying condition. Lifestyle modifications, such as regular exercise, a healthy diet, smoking cessation, and medication therapy, are essential for long-term management and prevention of further progression of the disease.

A "drug eruption" is a general term used to describe an adverse skin reaction that occurs as a result of taking a medication. These reactions can vary in severity and appearance, and may include symptoms such as rash, hives, itching, redness, blistering, or peeling of the skin. In some cases, drug eruptions can also cause systemic symptoms such as fever, fatigue, or joint pain.

The exact mechanism by which drugs cause eruptions is not fully understood, but it is thought to involve an abnormal immune response to the medication. There are many different types of drug eruptions, including morphilliform rashes, urticaria (hives), fixed drug eruptions, and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), which is a severe and potentially life-threatening reaction.

If you suspect that you are experiencing a drug eruption, it is important to seek medical attention promptly. Your healthcare provider can help determine the cause of the reaction and recommend appropriate treatment. In some cases, it may be necessary to discontinue the medication causing the reaction and switch to an alternative therapy.

Pseudolymphoma is a term used to describe a benign reactive lymphoid hyperplasia that mimics the clinical and histopathological features of malignant lymphomas. It is also known as pseudolymphomatous cutis or reactive lymphoid hyperplasia.

Pseudolymphoma can occur in various organs, but it is most commonly found in the skin. It is usually caused by a localized immune response to an antigenic stimulus such as insect bites, tattoos, radiation therapy, or certain medications. The condition presents as a solitary or multiple nodular lesions that may resemble lymphoma both clinically and histologically.

Histologically, pseudolymphoma is characterized by a dense infiltrate of lymphocytes, plasma cells, and other immune cells, which can mimic the appearance of malignant lymphoma. However, unlike malignant lymphomas, pseudolymphomas lack cytological atypia, mitotic activity, and clonal proliferation of lymphoid cells.

Pseudolymphoma is usually a self-limiting condition that resolves spontaneously or with the removal of the antigenic stimulus. However, in some cases, it may persist or recur, requiring further evaluation and treatment to exclude malignant lymphoma.

Acute Generalized Exanthematous Pustulosis (AGEP) is a severe cutaneous adverse reaction that typically occurs within 48 hours after the initiation of medication. It is characterized by the rapid development of widespread sterile pustules on an erythematous and edematous base, often accompanied by systemic symptoms such as fever and neutrophilia.

The most common triggers for AGEP are antibiotics (such as beta-lactams, macrolides, and fluoroquinolones), antifungals, and calcium channel blockers. The diagnosis of AGEP is based on clinical presentation, histopathological findings, and the exclusion of other causes of pustular eruptions.

The management of AGEP includes immediate discontinuation of the offending medication, supportive care, and sometimes systemic corticosteroids. The prognosis is generally good with most patients recovering within 2 weeks, although recurrences may occur upon re-exposure to the causative agent.

An exanthem is a skin eruption or rash that often occurs as a symptom of various diseases, such as infectious illnesses. It can appear in different forms, including maculopapular (consisting of both macules and papules), vesicular (small fluid-filled blisters), petechial (small purple or red spots caused by bleeding under the skin), or erythematous (reddened). The rash can be localized to certain areas of the body or generalized, covering large parts or the entire body. Exanthems are usually accompanied by other symptoms related to the underlying disease, such as fever, cough, or muscle aches.

Trimethoprim-sulfamethoxazole combination is an antibiotic medication used to treat various bacterial infections. It contains two active ingredients: trimethoprim and sulfamethoxazole, which work together to inhibit the growth of bacteria by interfering with their ability to synthesize folic acid, a vital component for their survival.

Trimethoprim is a bacteriostatic agent that inhibits dihydrofolate reductase, an enzyme needed for bacterial growth, while sulfamethoxazole is a bacteriostatic sulfonamide that inhibits the synthesis of tetrahydrofolate by blocking the action of the enzyme bacterial dihydropteroate synthase. The combination of these two agents produces a synergistic effect, increasing the overall antibacterial activity of the medication.

Trimethoprim-sulfamethoxazole is commonly used to treat urinary tract infections, middle ear infections, bronchitis, traveler's diarrhea, and pneumocystis pneumonia (PCP), a severe lung infection that can occur in people with weakened immune systems. It is also used as a prophylactic treatment to prevent PCP in individuals with HIV/AIDS or other conditions that compromise the immune system.

As with any medication, trimethoprim-sulfamethoxazole combination can have side effects and potential risks, including allergic reactions, skin rashes, gastrointestinal symptoms, and blood disorders. It is essential to follow the prescribing physician's instructions carefully and report any adverse reactions promptly.

Vesiculobullous skin diseases are a group of disorders characterized by the formation of blisters (vesicles) and bullae (larger blisters) on the skin. These blisters form when there is a separation between the epidermis (outer layer of the skin) and the dermis (layer beneath the epidermis) due to damage in the area where they join, known as the dermo-epidermal junction.

There are several types of vesiculobullous diseases, each with its own specific causes and symptoms. Some of the most common types include:

1. Pemphigus vulgaris: an autoimmune disorder where the immune system mistakenly attacks proteins that help to hold the skin together, causing blisters to form.
2. Bullous pemphigoid: another autoimmune disorder, but in this case, the immune system attacks a different set of proteins, leading to large blisters and inflammation.
3. Dermatitis herpetiformis: a skin condition associated with celiac disease, where gluten ingestion triggers an immune response that leads to the formation of itchy blisters.
4. Pemphigoid gestationis: a rare autoimmune disorder that occurs during pregnancy and causes blisters on the abdomen and other parts of the body.
5. Epidermolysis bullosa: a group of inherited disorders where there is a fragile skin structure, leading to blistering and wound formation after minor trauma or friction.

Treatment for vesiculobullous diseases depends on the specific diagnosis and may include topical or systemic medications, such as corticosteroids, immunosuppressants, or antibiotics, as well as wound care and prevention of infection.

Skin diseases, also known as dermatological conditions, refer to any medical condition that affects the skin, which is the largest organ of the human body. These diseases can affect the skin's function, appearance, or overall health. They can be caused by various factors, including genetics, infections, allergies, environmental factors, and aging.

Skin diseases can present in many different forms, such as rashes, blisters, sores, discolorations, growths, or changes in texture. Some common examples of skin diseases include acne, eczema, psoriasis, dermatitis, fungal infections, viral infections, bacterial infections, and skin cancer.

The symptoms and severity of skin diseases can vary widely depending on the specific condition and individual factors. Some skin diseases are mild and can be treated with over-the-counter medications or topical creams, while others may require more intensive treatments such as prescription medications, light therapy, or even surgery.

It is important to seek medical attention if you experience any unusual or persistent changes in your skin, as some skin diseases can be serious or indicative of other underlying health conditions. A dermatologist is a medical doctor who specializes in the diagnosis and treatment of skin diseases.

... may be toxic to the embryo and can be transferred via the umbilical cord and by milk. Phenylbutazone can be used ... Positive phenylbutazone tests in horse meat were uncommon in the UK, however. Phenylbutazone was originally made available for ... Phenylbutazone can also cause agranulocytosis. Phenylbutazone amplifies the anticoagulant effect of vitamin K antagonists such ... Phenylbutazone was legal on most tracks around the United States in 1968, but had not yet been approved by Churchill Downs. ...
"Phenylbutazone - National Library of Medicine HSDB Database". Toxnet.nlm.nih.gov. Archived from the original on 25 June 2014. ... Phenylbutazone is used therapeutically in humans as a treatment for ankylosing spondylitis when other treatments are not ... "Phenylbutazone (NSAID) (Chemical Page)". wildpro.twycrosszoo.org. 2 January 2011. Archived from the original on 30 April 2013. ... There is also speculation that some horse meat from the United States, where phenylbutazone is commonly used, may have entered ...
When the horse's post-Derby urinalysis revealed the phenylbutazone, his owner and handlers believed someone else may have been ... Carpenter, Steven L.; McDonnell, W. M. (1995). "Misuse of Veterinary Phenylbutazone". Archives of Internal Medicine. 155 (11): ... The use of phenylbutazone was subsequently approved on March 6, 1974, by the Kentucky Racing Commission in recognition of ... but winner Dancer's Image was disqualified to last place after traces of phenylbutazone were discovered in the mandatory post- ...
with P. L. Boardman: Hart FD, Boardman PL (27 November 1965). "Indomethacin and phenylbutazone: a comparison". Br Med J. 2 ( ...
Biron, P (15 May 1986). "Withdrawal of oxyphenbutazone: what about phenylbutazone?". CMAJ: Canadian Medical Association Journal ...
... is a nonsteroidal anti-inflammatory drug (NSAID). It is a metabolite of phenylbutazone. It was withdrawn from ... Matthews NS, Peck KE, Taylor TS, Mealey KL (May 2001). "Pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone ... Biron P (May 1986). "Withdrawal of oxyphenbutazone: what about phenylbutazone?". CMAJ. 134 (10): 1119-20. PMC 1491052. PMID ...
Phenylbutazone Generic term for a widely used analgesic medication in horses. Most common trade name is Butazolidin; often ... Butazolidin or bute See Phenylbutazone, below. Chalk The horse who runs a particular race at the best win odds; the favorite. A ...
Aspirin and phenylbutazone are associated with intrinsic hepatotoxicity; idiosyncratic reaction has been associated with ... ibuprofen, sulindac, phenylbutazone, piroxicam, diclofenac and indomethacin. Glucocorticoids are so named due to their effect ...
Phenylbutazone can partially reverse the beneficial effects of furosemide. Other ineffective treatments include leukocyte ... Other anti-inflammatory agents, such as hesperidin-citrus bioflavinoids, vitamin C, NSAIDs such as phenylbutazone, ...
Geller J (1968). "A comparative trial of aloxiprin ('Palaprin Forte') and phenylbutazone ('Butazolidin')". The British Journal ...
Anti-inflammatory agents: ibuprofen, indomethacin, phenylbutazone, oxyphenbutazone, acetazolamide, piroxicam, diclofenac. ...
Diclofenac, carprofen, flunixin, ibuprofen and phenylbutazone were associated with mortality. Meloxicam has thus far been found ...
Phenylbutazone is commonly used for its strong effect and relatively low cost. Flunixin (Banamine), ketofen, and others are ... However, firocoxib provides less pain relief than phenylbutazone or flunixin. Care must be taken that pain is not totally ... January 2005). Suxibuzone as a Therapeutical Alternative to Phenylbutazone in the Treatment of Lameness in Horses (PDF). 11th ... MacAllister CG, Morgan SJ, Borne AT, Pollet RA (January 1993). "Comparison of adverse effects of phenylbutazone, flunixin ...
Administration of phenylbutazone to a horse also receiving flunixin has been shown to increase the risk of toxicity without ... Reed SK, Messer NT, Tessman RK, Keegan KG (March 2006). "Effects of phenylbutazone alone or in combination with flunixin ... McConnico RS, Morgan TW, Williams CC, Hubert JD, Moore RM (November 2008). "Pathophysiologic effects of phenylbutazone on the ... Foreman JH, Ruemmler R (November 2011). "Phenylbutazone and flunixin meglumine used singly or in combination in experimental ...
When administered correctly, PLT has shown similar clinical efficacy to phenylbutazone. The effects of PLT toxicity in dogs are ...
Paradies HH (December 1987). "Structure of phenylbutazone and mofebutazone in the crystalline state and in solution". Journal ...
It is a prodrug of the non-steroidal anti-inflammatory drug (NSAID) phenylbutazone, and is commonly used in horses. Yasuda Y, ... and metabolism of suxibuzone and phenylbutazone in humans". Journal of Pharmaceutical Sciences. 71 (5): 565-72. doi:10.1002/jps ... randomised and blinded field study comparing efficacy of suxibuzone and phenylbutazone in lame horses". Equine Veterinary ...
However, this side effect does not occur with all drugs in the NSAID class, including phenylbutazone. Diclofenac is a topical ... 1993) Effects of large doses of phenylbutazone, flunixin meglumine, and ketoprofen in horses. J. Am. Vet. Med. Ass. 202, 71-77 ... Foreman, J. H.; Ruemmler, R. (2011). "Phenylbutazone and flunixin meglumine used singly or in combination in experimental ... The most commonly used NSAIDs in the United States is phenylbutazone, although flunixin meglumine and firocoxib are also ...
... phenylbutazone and flunixin". The British Veterinary Journal. 143 (5): 462-476. doi:10.1016/0007-1935(87)90024-8. PMID 3119142 ... although there was less effect on eicosanoid production when compared to the effects produced by NSAIDs such as phenylbutazone ...
In fact, phenylbutazone was shown superior to ketoprofen in cases of experimentally-induced synovitis when both drugs were used ... It is therefore not considered superior to phenylbutazone as previously believed, although clinical signs of lameness are ... "Effects of pretreatment with ketoprofen and phenylbutazone on experimentally induced synovitis in horses". American Journal of ...
... phenylbutazone. Clofezone was used to treat joint and muscular pain, but is not marketed any more. Berger A, Wachter H, eds. ( ... Comparative studies on the bioavailability of various drug forms of phenylbutazone and clofezone (Perclusone)]". Die Pharmazie ...
It is a combination of clofexamide, an antidepressant, and phenylbutazone, a nonsteroidal anti-inflammatory drug (NSAID). ... Comparative studies on the bioavailability of various drug forms of phenylbutazone and clofezone (Perclusone)]". Die Pharmazie ...
Other chemical exposures associated with the development of AML include benzene, chloramphenicol and phenylbutazone. High ...
The drug in question - phenylbutazone - is now legal for use on racehorses in many states, including Kentucky. Winners of the ... A urine test revealed traces of phenylbutazone (an anti-inflammatory painkiller drug) inside Dancer's Image. Forward Pass won ... allowing horses to run on phenylbutazone. In 1970, Diane Crump became the first female jockey to ride in the Derby, finishing ...
Anti-inflammatory drugs such as phenylbutazone can be used to ease pain and help control swelling. Treating pigeon fever with ...
Anecdotal reports that long-term use of phenylbutazone increases the risk of this reaction are unverified. After the animal has ...
Cardoe N, Steele CE (1976-1977). "A double-blind crossover comparison of tolmetin sodium and phenylbutazone in the treatment of ...
... is occasionally referred to as "bute" and this risks confusion with phenylbutazone, also called "bute". ... Phenylbutazone, which is a drug also used with horses, was tested for in the 2013 European meat adulteration scandal. Intended ...
It is an analog of phenylbutazone but instead of a n-butyl group it is prenylated. Koyama T, Izawa Y, Wada H, Makita T, ...
NSAIDs are commonly used (flunixin is the drug of choice, but phenylbutazone may also be used). Corticosteroids are sometimes ...
Phenylbutazone may be toxic to the embryo and can be transferred via the umbilical cord and by milk. Phenylbutazone can be used ... Positive phenylbutazone tests in horse meat were uncommon in the UK, however. Phenylbutazone was originally made available for ... Phenylbutazone can also cause agranulocytosis. Phenylbutazone amplifies the anticoagulant effect of vitamin K antagonists such ... Phenylbutazone was legal on most tracks around the United States in 1968, but had not yet been approved by Churchill Downs. ...
Learn about Phenylbutazone Tablets for Animal Use (Canada) including: active ingredients, directions for use, precautions, and ... Phenylbutazone Tablets (Canada). This page contains information on Phenylbutazone Tablets for veterinary use.. The information ...
Contains 200 mg phenylbutazone, 1.5% benzyl alcohol and purified water per ml. ... Contains 200 mg phenylbutazone, 1.5% benzyl alcohol and purified water per ml. ... Contains 200 mg phenylbutazone, 1.5% benzyl alcohol and purified water per ml. ...
Effect of Phenylbutazone, Flunixin Meglumine and Firocoxib on ex vivo Cyclo-oxygenase Activity in Horses Undergoing Elective ... Effect of Phenylbutazone, Flunixin Meglumine and Firocoxib on ex vivo Cyclo-oxygenase Activity in Horses Undergoing Elective ... phenylbutazone (4.4 mg/kg bwt i.v. b.i.d.), (2) flunixin meglumine (FM, 1.1 mg/kg bwt i.v. b.i.d.) and (3) firocoxib (FIR, 0.1 ...
Butatron Phenylbutazone Tablets are used for the relief of inflammatory conditions associated with the musculoskeletal system ... Butatron Tablets are a non-steroidal anti-inflammatory drug (NSAID). Each Butatron Tablet contains 1 gram phenylbutazone. The ... Butatron Phenylbutazone Tablets are used for the relief of inflammatory conditions associated with the musculoskeletal system ... Butatron Tablets are a non-steroidal anti-inflammatory drug (NSAID). Each Butatron Tablet contains 1 gram phenylbutazone. The ...
The effect of flunixin or phenylbutazone was maintained for at least 24 hours. Flunixin meglumine and phenylbutazone appear to ... Procedure-Horses received flunixin (1.1 mg/kg), phenylbutazone (4.4 mg/kg), or physiologic saline (0.9% NaCl; 1 mL/45 kg) ... or phenylbutazone-treated horses were not significantly different. Conclusions and Clinical Relevance-In horses with navicular ... syndrome treated once daily for 4 days, typical clinical doses of flunixin and phenylbutazone resulted in similar significant ...
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We know now there is an association between phenylbutazone and breakdown injuries ... Tim Parkin, indicated that he will call for policies that will allow zero phenylbutazone to be in the horses blood on race day ... The author of the study believes the increased odds of fatality in the horses using phenylbutazone are because these horses ... Parkin said that horses with phenylbutazone in their systems were 50% more likely to sustain a fatal or nonfatal ...
CAS Number: 129-18-0 Molecular Formula: C19H20N2NaO2 Standard:USP32/EP6 Package:25kg/drum
EQUI-PHAR PHENYLBUTAZONE INJECTION 20% Phenylbutazone-Injection. ANADA 200-371, Approved by FDA. Click here for SDS Active ... Phenylbutazone 200 mg. Benzyl alcohol 1.5%. Sodium hydroxide used to adjust pH and water for injection U.S.P.. Indications:. ...
COMPOSITION Each ml contains Phenylbutazone 180 mg, Dexamethasone (as sodium phosphate) 0.35 mg. INDICATION Anti inflammatory, ... Each ml contains Phenylbutazone 180 mg, Dexamethasone (as sodium phosphate) 0.35 mg. ... COMPOSITION Each ml contains Phenylbutazone 180 mg, Dexamethasone (as sodium phosphate) 0.35 mg. INDICATION Anti inflammatory, ...
Grovet is an independent Dutch veterinary-pharmaceutical wholesaler. Over 20 years we are active in the veterinary field of medicines, feed supplements and care products on sport-horses.
Phenylbutazone. Phenylbutazone causes an increase (by about 80%) in the free fraction of etodolac. Although in vivo studies ... have not been done to see if etodolac clearance is changed by coadministration of phenylbutazone, it is not recommended that ...
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Mathieu P, Villemot JP, Stoltz JF, Scheck F, Garnier LF (June 1996). "[Antiaggregant effect and tolerance of calcium carbasalate administrated immediately after aorto-coronary bypass. Results of a double-blind versus placebo study]". Pathologie-Biologie. 44 (6): 571-80. PMID 8977914 ...
InChI=1S/C16H14O5/c1-11(17)20-13-8-4-3-7-12(13)16(18)21-15-10-6-5-9-14(15)19-2/h3-10H,1- ...
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PHENYLBUTAZONE (PHENYLBUTAZONE) 100MG Marketing Status: Discontinued Active Ingredient: PHENYLBUTAZONE Proprietary Name: ... PHENYLBUTAZONE Dosage Form; Route of Administration: CAPSULE; ORAL Strength: 100MG Reference Listed Drug: No Reference Standard ...
Indomethacin and phenylbutazone: a comparison. BMJ 2:1281-1284.. View. Pollock TM, Bell JA, Hill AB, Cockburn WC, Cvjetanović B ...
Adverse reactions to medications are common and often manifest as a cutaneous eruption. Drug-induced cutaneous disorders frequently display a characteristic clinical morphology such as morbilliform exanthem, urticaria, hypersensitivity syndrome, pseudolymphoma, photosensitivity, pigmentary changes, acute generalized exanthematous pustulosis, ...
2) Each milliliter of solution contains 200 mg of phenylbutazone. (b) Sponsors. See sponsor numbers in § 510.600(c) of this ... a) Specifications. (1) Each milliliter of solution contains 100 milligrams (mg) of phenylbutazone. ...
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
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Detailed drug Information for Duo-Vil 2-25. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
If you are using this medicine for a long time, tell your doctor about any extra stress or anxiety in your life, including other health concerns and emotional stress. Your dose of this medicine might need to be changed for a short time while you have extra stress. Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. Talk to your doctor right away if you have more than one of these symptoms while you are using this medicine: blurred vision, dizziness or fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness. This medicine may cause you to get more infections than usual. Avoid people who are sick or have infections and wash your hands often. If you are exposed to chickenpox or measles, tell your doctor right away. If you start to have a fever, chills, sore throat, or any other sign of an infection, call your doctor right away. Check with your doctor right away ...
Phenylbutazone. Butazolidin. NSAID, Antiarthritic. Phenylpropanolamine + Chlorpheniramine. Ornade Spansule. Antihistamine. ...
  • Phenylbutazone, often referred to as "bute", is a nonsteroidal anti-inflammatory drug (NSAID) for the short-term treatment of pain and fever in animals. (wikipedia.org)
  • A recent study indicates that phenylbutazone, commonly called bute, is a risk factor for breakdown injuries in racehorses. (vin.com)
  • The author of the study believes the increased odds of fatality in the horses using phenylbutazone are because these horses need pain medication to race and bute may allow the horses to continue racing and training. (vin.com)
  • PHENYLBUTAZONE Injection (200mg/ml) (also known as bute) is a non-steroidal anti-inflammatory drug. (racehorsemed.co)
  • Equipalazone contains 1g of phenylbutazone (bute). (emgora.ru)
  • Bute Phenylbutazone Powder for Horses soothe your equine's swelling and discomfort with Bute Powder for Horses. (emgora.ru)
  • Equipalazone Oral Powder is supplied in sachets, each containing 1g of Phenylbutazone ("bute"), a drug from the NSAID group (Non Steroidal Anti-inflammatory. (emgora.ru)
  • Buy Bute Phenylbutazone from Canada. (emgora.ru)
  • SMART BUTE (Phenylbutazone 2 gm/scoop + Omeprazole 1 gm/scoop), Oral Powder, 30 Scoops (20cc Scoop) Lameness in horses is not a specific condition in horses. (emgora.ru)
  • Jul 13, - Buy Bute (phenylbutazone) Phenylbutazone Powder for Horses, lbs at emgora.ru FREE shipping and the BEST customer service! (emgora.ru)
  • No products which contained horse DNA also tested positive for the veterinary drug phenylbutazone or bute. (foodmanufacture.co.uk)
  • Phenylbutazone is the most commonly used NSAID for horses in the United States. (wikipedia.org)
  • Horses (n = 18) undergoing elective surgery were recruited and allocated to treatment groups depending on clinician preference (1) phenylbutazone (4.4 mg/kg bwt i.v. b.i.d.), (2) flunixin meglumine (FM, 1.1 mg/kg bwt i.v. b.i.d.) and (3) firocoxib (FIR, 0.1 mg/kg bwt i.v. s.i.d. (ivis.org)
  • Butatron Phenylbutazone Tablets are used for the relief of inflammatory conditions associated with the musculoskeletal system in horses. (valleyvet.com)
  • Buy 3 Butatron Phenylbutazone for Horses (item 1380RX) and save! (valleyvet.com)
  • Objective -To use force plate analysis to evaluate the analgesic efficacies of flunixin meglumine and phenylbutazone administered IV at typical clinical doses in horses with navicular syndrome. (avma.org)
  • at those time points, the assessed variables in flunixin- or phenylbutazone-treated horses were not significantly different. (avma.org)
  • Conclusions and Clinical Relevance -In horses with navicular syndrome treated once daily for 4 days, typical clinical doses of flunixin and phenylbutazone resulted in similar significant improvement in lameness at 6, 12, and 24 hours after the final dose, compared with findings in horses treated with saline solution. (avma.org)
  • Flunixin meglumine and phenylbutazone appear to have similar analgesic effects in horses with navicular syndrome. (avma.org)
  • Dr. Parkin said that horses with phenylbutazone in their systems were 50% more likely to sustain a fatal or nonfatal musculoskeletal injury than those racing without a non-steroidal drug in their system. (vin.com)
  • Phenylbutazone Powder for horses is pain medicine for horses used to relieve inflammatory conditions associated with the musculoskeletal system. (emgora.ru)
  • Phenylbutazone is a synthetic, non-hormonal, anti-inflammatory agent that is indicated for the relief of inflammatory conditions in horses. (emgora.ru)
  • Clinical and serum variables, colonic inflammation (histologic grading), and measurement of myeloperoxidase (MPO) activity, malondialdehyde (MDA) and prostaglandin E 2 (PGE 2 ) concentrations, ingesta volatile fatty acid (VFA) content, and arterial blood flow in the RDC were evaluated for a 21-day period in horses administered phenylbutazone (8.8 mg/kg, PO, q 24 h) or a control substance. (avma.org)
  • Two horses developed colitis while receiving phenylbutazone. (avma.org)
  • COMPOSITION Each ml contains Phenylbutazone 180 mg, Dexamethasone (as sodium phosphate) 0.35 mg. (fangtongpharm.com)
  • Although phenylbutazone is available as an injection, tablets, and paste, the powder form may be. (emgora.ru)
  • Contains 200 mg phenylbutazone, 1.5% benzyl alcohol and purified water per ml. (pbsanimalhealth.com)
  • This page contains information on Phenylbutazone Tablets for veterinary use . (drugs.com)
  • Phenylbutazone can be administered orally (via paste, powder or feed-in) or intravenously. (wikipedia.org)
  • A & G Pharmaceutical Inc. Equizone™, Palatable Phenylbutazone Flavored Powder. (emgora.ru)
  • Equizone (phenylbutazone) Powder. (emgora.ru)
  • Limit intravenous (IV) administration to a maximum of 5 successive days, which may be followed by oral phenylbutazone dosage forms. (racehorsemed.co)
  • This citrus-flavored powder is made with a specially targeted ingredient-phenylbutazone-which helps to relieve swelling by blocking specific enzymes. (emgora.ru)
  • No other clinical or hematologic abnormalities were detected for phenylbutazone or control treatments. (avma.org)
  • 1. Use a relatively high dose of PHENYLBUTAZONE for the first 48 hours, then reduce gradually to a maintenance dose. (racehorsemed.co)
  • Side effects of phenylbutazone are similar to those of other NSAIDs. (wikipedia.org)
  • 4. Many chronic conditions will respond to p PHENYLBUTAZONE therapy, but discontinued treatment may result in recurrence of symptoms. (racehorsemed.co)
  • Below are symptoms of a phenylbutazone overdose in different parts of the body. (medlineplus.gov)
  • Side effects of phenylbutazone in dogs include gastrointestinal (GI) ulceration, bone marrow depression, rashes, malaise, blood dyscrasias, and diminished renal blood flow. (wikipedia.org)
  • She found multiple risk factors for breakdown injuries that had been found previously, but hers was the first study to find the association between phenylbutazone and breakdown injuries. (vin.com)
  • Phenylbutazone is occasionally used in dogs for the longer-term management of chronic pain, particularly due to osteoarthritis. (wikipedia.org)
  • Dogs receiving chronic phenylbutazone therapy should be followed with regular blood work and renal monitoring. (wikipedia.org)
  • Phenylbutazone was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in 1949. (wikipedia.org)
  • Plasma albumin concentrations decreased significantly from days 10 to 21 during phenylbutazone treatment, compared with results during the same days for the control treatment. (avma.org)
  • 2. Response to PHENYLBUTAZONE therapy is prompt, usually occurring within 24 hours. (racehorsemed.co)
  • Positive phenylbutazone tests in horse meat were uncommon in the UK, however. (wikipedia.org)
  • The effect of flunixin or phenylbutazone was maintained for at least 24 hours. (avma.org)
  • Phenylbutazone exerted no inhibiting effect. (erowid.org)
  • She was treated with penicillin twice a day, phenylbutazone, and vitamin B1 over the next 3 days. (cdc.gov)
  • 3. In animals, PHENYLBUTAZONE is largely metabolized in 8 hours. (racehorsemed.co)
  • No significant differences were detected in the RDC between phenylbutazone and control treatments for MPO activity, MDA and PGE 2 concentrations, and histologic evidence of inflammation. (avma.org)
  • After looking at this study, the epidemiologist for the Jockey Club, Dr. Tim Parkin, indicated that he will call for policies that will allow zero phenylbutazone to be in the horse's blood on race day. (vin.com)
  • The test found Warrior's Charge had phenylbutazone in his blood after the Stephen Foster Stakes. (lex18.com)
  • Phenylbutazone has a plasma elimination half-life of 4-8 hours, however the inflammatory exudate half life is 24 hours, so single daily dosing can be sufficient, although it is often used twice per day. (wikipedia.org)
  • In the 1968 Kentucky Derby, Dancer's Image, the winner of the race, was disqualified after traces of phenylbutazone were allegedly discovered in a post-race urinalysis. (wikipedia.org)