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PhenanthrenesPolycyclic Hydrocarbons, AromaticBiodegradation, EnvironmentalSoil PollutantsPyrenesDelftiaPolycyclic CompoundsPolyporusSphingomonasPolyporaceaePolyporalesBay-Region, Polycyclic Aromatic HydrocarbonHumic SubstancesSoil MicrobiologyNaphthalenesChrysenesHydrocarbons, AromaticAnthracenesNaphtholsDioxygenasesDendrobiumHydrocarbonsGonanesButylaminesStereoisomerismBasidiomycotaEpoxy CompoundsDNA AdductsMucoralesCreosoteGram-Negative Aerobic BacteriaPoloxaleneFluorenesDioscoreaBromine CompoundsBiotransformationAdsorptionPetroleumRalstoniaWater Pollution, ChemicalMycobacteriumMutagensLigninGas Chromatography-Mass SpectrometryBurkholderiaSphingomonadaceaePseudomonasCarcinogensOxygenasesHydroponicsBiphenyl CompoundsBacteriaAnnonaceaeMutagenicity TestsAporphinesBenzo(a)pyreneAzaguanine
PhenanthrenesPolycyclic Hydrocarbons, Aromatic: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)Biodegradation, Environmental: Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.Soil Pollutants: Substances which pollute the soil. Use for soil pollutants in general or for which there is no specific heading.Pyrenes: A group of condensed ring hydrocarbons.Delftia: A genus of gram-negative, strictly aerobic chemoorganotrophic bacteria, in the family COMAMONADACEAE.Polycyclic Compounds: Compounds consisting of two or more fused ring structures.Polyporus: A genus of basidiomyceteous fungi in the family POLYPORACEAE found mostly on living trees or dead wood.Sphingomonas: A genus of gram-negative, aerobic, rod-shaped bacteria characterized by an outer membrane that contains glycosphingolipids but lacks lipopolysaccharide. They have the ability to degrade a broad range of substituted aromatic compounds.Polyporaceae: A family of bracket fungi, order POLYPORALES, living in decaying plant matter and timber.Polyporales: An order of fungi in the phylum BASIDIOMYCOTA having macroscopic basidiocarps. The members are characterized by their saprophytic activities as decomposers, particularly in the degradation of CELLULOSE and LIGNIN. A large number of species in the order have been used medicinally. (From Alexopoulos, Introductory Mycology, 4th ed, pp504-68)Bay-Region, Polycyclic Aromatic Hydrocarbon: A concave exterior region on some POLYCYCLIC AROMATIC HYDROCARBONS that have three phenyl rings in a non-linear arrangement.Humic Substances: Organic matter in a state of advanced decay, after passing through the stages of COMPOST and PEAT and before becoming lignite (COAL). It is composed of a heterogenous mixture of compounds including phenolic radicals and acids that polymerize and are not easily separated nor analyzed. (E.A. Ghabbour & G. Davies, eds. Humic Substances, 2001).Soil Microbiology: The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.Naphthalenes: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.Chrysenes: 1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.Hydrocarbons, Aromatic: Organic compounds containing carbon and hydrogen in the form of an unsaturated, usually hexagonal ring structure. The compounds can be single ring, or double, triple, or multiple fused rings.Anthracenes: A group of compounds with three aromatic rings joined in linear arrangement.Naphthols: Naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. They are often used in dyes and pigments, as antioxidants for rubber, fats, and oils, as insecticides, in pharmaceuticals, and in numerous other applications.Dioxygenases: Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.Dendrobium: A plant genus of the family ORCHIDACEAE that contains dihydroayapin (COUMARINS) and phenanthraquinones.HydrocarbonsGonanes: Steroids containing the fundamental tetracyclic unit with no methyl groups at C-10 and C-13 and with no side chain at C-17. The concept includes both saturated and unsaturated derivatives.ButylaminesStereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Basidiomycota: A phylum of fungi that produce their sexual spores (basidiospores) on the outside of the basidium. It includes forms commonly known as mushrooms, boletes, puffballs, earthstars, stinkhorns, bird's-nest fungi, jelly fungi, bracket or shelf fungi, and rust and smut fungi.Epoxy Compounds: Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.DNA Adducts: The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.Mucorales: An order of zygomycetous fungi, usually saprophytic, causing damage to food in storage, but which may cause respiratory infection or MUCORMYCOSIS in persons suffering from other debilitating diseases.Creosote: A greasy substance with a smoky odor and burned taste created by high temperature treatment of BEECH and other WOOD; COAL TAR; or resin of the CREOSOTE BUSH. It contains CRESOLS and POLYCYCLIC AROMATIC HYDROCARBONS which are CARCINOGENS. It has been widely used as wood preservative and in PESTICIDES and had former use medicinally in DISINFECTANTS; LAXATIVES; and DERMATOLOGIC AGENTS.Gram-Negative Aerobic Bacteria: A large group of aerobic bacteria which show up as pink (negative) when treated by the gram-staining method. This is because the cell walls of gram-negative bacteria are low in peptidoglycan and thus have low affinity for violet stain and high affinity for the pink dye safranine.Poloxalene: A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.Fluorenes: A family of diphenylenemethane derivatives.Dioscorea: A plant genus best known for edible underground tubers. Yam may also refer to a moist variety of sweet potato, IPOMOEA BATATAS.Bromine Compounds: Inorganic compounds that contain bromine as an integral part of the molecule.Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Adsorption: The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.Petroleum: Naturally occurring complex liquid hydrocarbons which, after distillation, yield combustible fuels, petrochemicals, and lubricants.Ralstonia: A genus in the family BURKHOLDERIACEAE, comprised of many species. They are associated with a variety of infections including MENINGITIS; PERITONITIS; and URINARY TRACT INFECTIONS.Water Pollution, Chemical: Adverse effect upon bodies of water (LAKES; RIVERS; seas; groundwater etc.) caused by CHEMICAL WATER POLLUTANTS.Mycobacterium: A genus of gram-positive, aerobic bacteria. Most species are free-living in soil and water, but the major habitat for some is the diseased tissue of warm-blooded hosts.Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.Lignin: The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed)Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Burkholderia: A genus of gram-negative, aerobic, rod-shaped bacteria. Organisms in this genus had originally been classified as members of the PSEUDOMONAS genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Pseudomonas species, and hence, this new genus was created.Sphingomonadaceae: A family of gram-negative, asporogenous rods or ovoid cells, aerobic or facultative anaerobic chemoorganotrophs. They are commonly isolated from SOIL, activated sludge, or marine environments.Pseudomonas: A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Oxygenases: Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.Hydroponics: A technique for growing plants in culture solutions rather than in soil. The roots are immersed in an aerated solution containing the correct proportions of essential mineral salts. (From Concise Dictionary of Biology, 1990)Biphenyl CompoundsBacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Annonaceae: The custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.Mutagenicity Tests: Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.Aporphines: Dibenzoquinolines derived in plants from (S)-reticuline (BENZYLISOQUINOLINES).Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.Azaguanine: One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.

An investigation into the binding of the carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one to DNA in vitro. (1/766)

After metabolic activation the carcinogen 15,16-dihydro-11-[3H]methylcyclopenta[a]phenanthren-17-one binds to DNA in vitro, and this binding is prevented by 7,8-benzoflavone. Radioactivity cannot be removed from the DNA with organic solvents or by chromatography on Sephadex G-50, even after heat denaturation of the DNA. Enzymatic hydrolysis yields radioactive fractions, which elute from a column of Sephadex LH-20 immediately after the natural nucleosides. At least two species of reactive metabolites are involved in this bending, those with a half-life of a few hr and others with greater stability. After extraction from the aqueous incubation mixture, they could be detected in discrete polar fractions from separations of the complex metabolite mixture by high-pressure liquid chromatography. Their ability to bind to DNA decreased with time at ambient temperature, and they were rapidly deactivated by acid. 7,8-Benzolflavone acted by suppressing the formation of polar metabolites derived from enzymatic oxidation of the aromatic double bonds. The inhibitor had no effect on the enzymes hydroxylating saturated carbon; hence it is unlikely that metabolism of the methyl group is important in conversion of this carcinogen to its proximate form, although the presence of the 11-methyl group is essential for carcinogenic activity in this series.  (+info)

Contrasting effects of a nonionic surfactant on the biotransformation of polycyclic aromatic hydrocarbons to cis-dihydrodiols by soil bacteria. (2/766)

The biotransformation of the polycyclic aromatic hydrocarbons (PAHs) naphthalene and phenanthrene was investigated by using two dioxygenase-expressing bacteria, Pseudomonas sp. strain 9816/11 and Sphingomonas yanoikuyae B8/36, under conditions which facilitate mass-transfer limited substrate oxidation. Both of these strains are mutants that accumulate cis-dihydrodiol metabolites under the reaction conditions used. The effects of the nonpolar solvent 2,2,4, 4,6,8,8-heptamethylnonane (HMN) and the nonionic surfactant Triton X-100 on the rate of accumulation of these metabolites were determined. HMN increased the rate of accumulation of metabolites for both microorganisms, with both substrates. The enhancement effect was most noticeable with phenanthrene, which has a lower aqueous solubility than naphthalene. Triton X-100 increased the rate of oxidation of the PAHs with strain 9816/11 with the effect being most noticeable when phenanthrene was used as a substrate. However, the surfactant inhibited the biotransformation of both naphthalene and phenanthrene with strain B8/36 under the same conditions. The observation that a nonionic surfactant could have such contrasting effects on PAH oxidation by different bacteria, which are known to be important for the degradation of these compounds in the environment, may explain why previous research on the application of the surfactants to PAH bioremediation has yielded inconclusive results. The surfactant inhibited growth of the wild-type strain S. yanoikuyae B1 on aromatic compounds but did not inhibit B8/36 dioxygenase enzyme activity in vitro.  (+info)

Antimalarial activities of various 9-phenanthrenemethanols with special attention to WR-122,455 and WR-171,669. (3/766)

Pilot appraisals of the activities of 16 specially selected 9-phenanthrenemethanols against acute infections with Plasmodium falciparum in owl monkeys showed that all were more active than the reference compound, WR-33,063. WR-122,455, the most active derivative, and WR-171,669, ranked sixth, were selected for study in human volunteers. To assist this undertaking, appraisals of both compounds in owl monkeys infected with various strains of P. falciparum were expanded. These assessments showed: (i) that WR-122,455 was four times as active as chloroquine against infections with chloroquine-sensitive strains and that WR-171,669 equalled chloroquine in activity; (ii) that these compounds were fully active against infections with strains resistant to chloroquine, pyrimethamine, or quinine, or to all three standard drugs; (iii) that the activity of WR-122,455 was a function of total dose, single doses being as effective as the same amounts delivered in three or seven daily fractions; and (iv) that a single dose of WR-122,455 conferred extended, although only partial, protection against challenges with trophozoites. Complementary experiments in rhesus monkeys inoculated with sporozoites of P. cynomolgi showed that the activity of WR-122,455 was limited to blood schizonts and did not extend to early or late tissue schizonts. These evaluations were compatible with the results of preliminary studies of the activities of WR-122,455 and WR-171,669 in human volunteers.  (+info)

Inhibition of GABA-gated chloride channels by 12,14-dichlorodehydroabietic acid in mammalian brain. (4/766)

1. 12,14-dichlorodehydroabietic acid (12,14-Cl2DHA) reduced GABA-stimulated uptake of 36Cl- into mouse brain synaptoneurosomes suggesting inhibition of mammalian GABA(A) receptor function. 2. 12,14-Cl2DHA did not affect the binding of [3H]-muscimol to brain membranes but displaced specifically bound [3H]-EBOB. The inhibitory effect on [3H]-EBOB binding was not reversible. 12,14-Cl2DHA reduced the availability of [3H]-EBOB binding sites (Bmax) without changing the KD of the radioligand for remaining sites. 12,14-Cl2DHA did not affect the rate of association of [3H]-EBOB with its chloride channel receptor, but increased the initial rate of [3H]-EBOB dissociation. 3. 12,14-Cl2DHA enhanced the incidence of EPSCs when rapidly applied to cultured rat cortical neurones. Longer exposures produced block of IPSCs with marked increases in the frequency of EPSCs and min EPSCs. 12,14-Cl2DHA also irreversibly suppressed chloride currents evoked by pulses of exogenous GABA in these cells. 4. Ultimately, 12,14-Cl2DHA inhibited all synaptic traffic and action currents in current clamped cells indicating that, in contrast to picrotoxinin (which causes paroxysmal bursting), it is not fully selective for the GABA(A) receptor-chloride channel complex. 5. The depolarizing block seen with 12,14-Cl2DHA in amphotericin-perforated preparations implicates loss of Ca2+ buffering in the polarity change and this may account for inhibition of spontaneous action potentials. 6. Our investigation demonstrates that 12,14-Cl2DHA blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive insurmountable GABA(A) antagonist. The mechanism likely involves either irreversible binding of 12,14-Cl2DHA to the trioxabicyclooctane recognition site or a site that is allosterically coupled to it. We cannot exclude, however, the possibility that 12,14-Cl2DHA causes localized proteolysis or more extensive conformational change within a critical subunit of the chloride channel.  (+info)

A novel aromatic-ring-hydroxylating dioxygenase from the diterpenoid-degrading bacterium Pseudomonas abietaniphila BKME-9. (5/766)

Pseudomonas abietaniphila BKME-9 is able to degrade dehydroabietic acid (DhA) via ring hydroxylation by a novel dioxygenase. The ditA1, ditA2, and ditA3 genes, which encode the alpha and beta subunits of the oxygenase and the ferredoxin of the diterpenoid dioxygenase, respectively, were isolated and sequenced. The ferredoxin gene is 9. 2 kb upstream of the oxygenase genes and 872 bp upstream of a putative meta ring cleavage dioxygenase gene, ditC. A Tn5 insertion in the alpha subunit gene, ditA1, resulted in the accumulation by the mutant strain BKME-941 of the pathway intermediate, 7-oxoDhA. Disruption of the ferredoxin gene, ditA3, in wild-type BKME-9 by mutant-allele exchange resulted in a strain (BKME-91) with a phenotype identical to that of the mutant strain BKME-941. Sequence analysis of the putative ferredoxin indicated that it is likely to be a [4Fe-4S]- or [3Fe-4S]-type ferredoxin and not a [2Fe-2S]-type ferredoxin, as found in all previously described ring-hydroxylating dioxygenases. Expression in Escherichia coli of ditA1A2A3, encoding the diterpenoid dioxygenase without its putative reductase component, resulted in a functional enzyme. The diterpenoid dioxygenase attacks 7-oxoDhA, and not DhA, at C-11 and C-12, producing 7-oxo-11, 12-dihydroxy-8,13-abietadien acid, which was identified by 1H nuclear magnetic resonance, UV-visible light, and high-resolution mass spectrometry. The organization of the genes encoding the various components of the diterpenoid dioxygenase, the phylogenetic distinctiveness of both the alpha subunit and the ferredoxin component, and the unusual Fe-S cluster of the ferredoxin all suggest that this enzyme belongs to a new class of aromatic ring-hydroxylating dioxygenases.  (+info)

Effect of selected antimalarial drugs and inhibitors of cytochrome P-450 3A4 on halofantrine metabolism by human liver microsomes. (6/766)

Halofantrine (HF) is used in the treatment of uncomplicated multidrug-resistant Plasmodium falciparum malaria. Severe cardiotoxicity has been reported to be correlated with high plasma concentrations of HF but not with that of its metabolite N-debutylhalofantrine. The aim of this study was to investigate the effects of other antimalarial drugs and of ketoconazole, a typical cytochrome P-450 3A4 inhibitor, on HF metabolism by human liver microsomes. Antimalarial drug inhibitory effects were ranked as follows: primaquine > proguanil > mefloquine > quinine > quinidine > artemether > amodiaquine. Artemisine, doxycycline, sulfadoxine, and pyrimethamine showed little or no inhibition of HF metabolism. Mefloquine, quinine, quinidine, and ketoconazole used at maximal plasma concentrations inhibited N-debutylhalofantrine formation noncompetitively with Ki values of 70 microM, 49 microM, 62 microM, and 0.05 microM resulting in 7%, 49%, 26%, and 99% inhibition, respectively, in HF metabolism. In conclusion, we showed that quinine and quinidine coadministered with HF might inhibit its metabolism resulting in the potentiation of HF-induced cardiotoxicity in patients. This requires a close monitoring of ECG. For the same reasons, the concomitant administration of HF and ketoconazole must be avoided. By contrast, none of the other antimalarials studied inhibited HF metabolism and, by extrapolation, cytochrome P-450 3A4 activity.  (+info)

Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. (7/766)

PG490 (triptolide) is a diterpene triepoxide with potent immunosuppressive and antiinflammatory properties. PG490 inhibits interleukin(IL)-2 expression by normal human peripheral blood lymphocytes stimulated with phorbol 12-myristate 13-acetate (PMA) and antibody to CD3 (IC50 of 10 ng/ml), and with PMA and ionomycin (Iono, IC50 of 40 ng/ml). In Jurkat T-cells, PG490 inhibits PMA/Iono-stimulated IL-2 transcription. PG490 inhibits the induction of DNA binding activity at the purine-box/antigen receptor response element (ARRE)/nuclear factor of activated T-cells (NF-AT) target sequence but not at the NF-kappaB site. PG490 can completely inhibit transcriptional activation at the purine-box/ARRE/NF-AT and NF-kappaB target DNA sequences triggered by all stimuli examined (PMA, PMA/Iono, tumor necrosis factor-alpha). PG490 also inhibits PMA-stimulated activation of a chimeric transcription factor in which the C-terminal TA1 transactivation domain of NF-kappaB p65 is fused to the DNA binding domain of GAL4. In 16HBE human bronchial epithelial cells, IL-8 expression is regulated predominantly by NF-kappaB, and PG490 but not cyclosporin A can completely inhibit expression of IL-8. The mechanism of PG490 inhibition of cytokine gene expression differs from cyclosporin A and involves nuclear inhibition of transcriptional activation of NF-kappaB and the purine-box regulator operating at the ARRE/NF-AT site at a step after specific DNA binding.  (+info)

PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells. (8/766)

Progress in the treatment of solid tumors has been slow and sporadic. The efficacy of conventional chemotherapy in solid tumors is limited because tumors frequently have mutations in the p53 gene. Also, chemotherapy only kills rapidly dividing cells. Members of the tumor necrosis factor (TNF) family, however, induce apoptosis regardless of the p53 phenotype. Unfortunately, the cytotoxicity of TNF-alpha is limited by its activation of NF-kappaB and activation of NF-kappaB is proinflammatory. We have identified a compound called PG490, that is composed of purified triptolide, which induces apoptosis in tumor cells and sensitizes tumor cells to TNF-alpha-induced apoptosis. PG490 potently inhibited TNF-alpha-induced activation of NF-kappaB. PG490 also blocked TNF-alpha-mediated induction of c-IAP2 (hiap-1) and c-IAP1 (hiap-2), members of the inhibitor of apoptosis (IAP) family. Interestingly, PG490 did not block DNA binding of NF-kappaB, but it blocked transactivation of NF-kappaB. Our identification of a compound that blocks TNF-alpha-induced activation of NF-kappaB may enhance the cytotoxicity of TNF-alpha on tumors in vivo and limit its proinflammatory effects.  (+info)

Efficacy and Safety Study of Sodium Tanshinone IIA Sulfonate on Pulmonary Hypertension - Full Text View - ClinicalTrials.govEfficacy and Safety Study of Sodium Tanshinone IIA Sulfonate on Pulmonary Hypertension - Full Text View - ClinicalTrials.gov
Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine,the dried root of Salvia miltiorrhiza Bunge known as Danshen. Danshen has been known for the function of improving body functions such as activating blood circulation and removing blood stasis according to the theory of traditional Chinese medicine. Danshen and its various formula products including STS have been long-time widely used in oriental countries, especially China to treat various inflammatory and cardiovascular diseases for its pharmacological actions, including vasodilatation, anticoagulation, anti-inflammation, and free radical scavenging,with negligible adverse effects observed.. The investigators objective is to evaluate whether STS exhibits beneficial effects on pulmonary hypertension. This is a randomized, controlled, multicentre clinical trial study. 90 patients with pulmonary ...
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Two diol-epoxide metabolites of benzo[c]phenanthrene and benzo[a]pyrene, polynuclear aromatic hydrocarbons which occur in the environment, were tested for carcinogenicity by direct injection into the mammary fat pads of female CD rats. The compounds anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene (BcPDE), a fjord region diol-epoxide, and anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a bay region diol-epoxide, were applied at total doses of 12.2 µmol. 6-Nitrochrysene was applied at the same dose as a positive control (K. El-Bayoumy, A. Rivenson, P. Upadhyaya, Y-H. Chae, and S. S. Hecht, Cancer Res. 53: 3719-3722, 1993). The sterically hindered fjord region diol-epoxide BcPDE was a powerful mammary tumorigen and carcinogen, rapidly inducing significantly more fibroadenoma and adenocarcinoma than either of the other compounds. Anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene was a weaker mammary tumorigen than BcPDE and 6-nitrochrysene. The ...
Impairment of triptolide on liver mitochondria in isolated liver mitochondria and HL7702 cell line. - Semantic ScholarImpairment of triptolide on liver mitochondria in isolated liver mitochondria and HL7702 cell line. - Semantic Scholar
OBJECTIVE To observe the impairing effects of triptolide on liver mitochondria in isolated rat-liver mitochondria and human normal liver HL7702 cell line. METHODS Rat-liver mitochondria were isolated from adult female Sprague-Dawley (SD) rats. Liver mitochondria were incubated with 0, 1.25, 2.5, 5 and 10 μmol/L triptolide for detecting mitochondrial swelling and with 0, 2.5, 5 and 10 μmol/L triptolide for mitochondrial permeability transition pore (MPTP) activity. Mitochondrial swelling was estimated by measuring the apparent absorbance change during 600 s in the mitochondrial suspensions at 520 nm with a mitochondrial swelling examining kit. The effect of triptolide on MPTP was determined with a fluorescence detection kit by detecting the fluorescence intensity at an excitation wavelength of 488 nm emitted at 527 nm. Human normal liver HL7702 cells were treated without or with 0.02, 0.1 and 0.5 μmol/L triptolide for 24 h for analyzing mitochondrial transmembrane potential (Δψm) and reactive
Effects of Soil/Sediment Organic Matter on the Desorption, Bioavailability, Sequestration, and Transformation of Phenanthrene |...Effects of Soil/Sediment Organic Matter on the Desorption, Bioavailability, Sequestration, and Transformation of Phenanthrene |...
Three geosorbents were characterized using 13C-NMR to determine the relative degree of hard and soft carbon. Michigan peat is a relatively young soil from which phenanthrene readily desorbs; Chelsea soil is a high-organic, muck-type top soil with an intermediate hysteresis index; and Lachine shale is a geologically old soil with a high hysteresis index. The sorption isotherms were fit to the Freundlich equation. Soils were aged under anoxic conditions for 2 or 4 months, and the mass of nonradiolabeled phenanthrene was varied to achieve a constant equilibrium aqueous concentration. Radiolabeled phenanthrene in methanol was added to each bottle as a tracer. The bioflasks consisted of a 250-mL flask with a center well for sodium hydroxide (NaOH) and a side arm. A concentrated mineral-nutrient solution and a cell solution of Pseudomonas CRE7, a phenanthrene degrader, were added to the flasks. The NaOH was removed from the center well at sampling to measure the extent of mineralization. Oxygen was ...
Frontiers | Isolation and Characterization of Phenanthrene Degrading Bacteria from Diesel Fuel-Contaminated Antarctic Soils |...Frontiers | Isolation and Characterization of Phenanthrene Degrading Bacteria from Diesel Fuel-Contaminated Antarctic Soils |...
Antarctica is an attractive target for human exploration and scientific investigation, however the negative effects of human activity on this continent are long lasting and can have serious consequences on the native ecosystem. Various areas of Antarctica have been contaminated with diesel fuel, which contains harmful compounds such as heavy metals and polycyclic aromatic hydrocarbons (PAH). Bioremediation of PAHs by the activity of microorganisms is an ecological, economical and safe decontamination approach. Since the introduction of foreign organisms into the Antarctica is prohibited, it is key to discover native bacteria that can be used for diesel bioremediation. By following the degradation of the PAH phenanthrene, we isolated 53 PAH metabolizing bacteria from diesel contaminated Antarctic soil samples, with three of these isolates exhibiting a high phenanthrene degrading capacity. In particular, the Sphingobium xenophagum D43FB isolate showed the highest phenanthrene degradation ability,
Items where Author is Ajima, M N O - CMFRI RepositoryItems where Author is "Ajima, M N O" - CMFRI Repository
Sukhadane, Kapil S and Pandey, A K and Ajima, M N O and Jayakumar, Teena and Vennila, A and Raut, Shailendra M (2017) Isolation and Characterization of Phenanthrene-Degrading Bacteria from PAHs Contaminated Mangrove Sediment of Thane Creek in Mumbai, India. Polycyclic Aromatic Compounds. pp. 1-11. Bharti, Vivekanand and Pandey, P K and Alagarsamy, V and Rajkumar, M and Ajima, M N O (2016) Water Quality, Survival and Growth Performance of Cirrhinus mrigala (Hamilton 1822) in Substrate Based Tanks. Asian Fisheries Science, 29. pp. 137-150. Sukhadane, Kapil S and Pandey, P K and Vennila, A and Purushothaman, C S and Ajima, M N O (2015) Sources, distribution and risk assessment of polycyclic aromatic hydrocarbons in the mangrove sediments of Thane Creek, Maharashtra, India. Environmental Monitoring and Assessment. pp. 187-274. ...
phenanthrene 85-01-8 Chemical Safety Info Safety Infophenanthrene 85-01-8 Chemical Safety Info Safety Info
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Deuterated Phenanthrene Tetraol in Smokers Who Are at High Risk For Lung Cancer - Full Text View - ClinicalTrials.govDeuterated Phenanthrene Tetraol in Smokers Who Are at High Risk For Lung Cancer - Full Text View - ClinicalTrials.gov
PRIMARY OBJECTIVES:. I. To determine the relationship between urinary deuterated ([D10]) phenanthrene tetraol (PheT) level, PheT:phenanthrols (HOPhe) ratio, and the presence of bronchoepithelial metaplasia and/or dysplasia in smokers who have undergone screening bronchoscopy at Roswell Park Cancer Institute (RPCI).. OUTLINE:. Patients receive deuterated phenanthrene tetraol orally (PO). Urine samples are collected for laboratory studies for 6 hours after dosing. ...
Molecular structure in relation to oestrogenic activity. Compounds without a phenanthrene nucleus | Proceedings of the Royal...Molecular structure in relation to oestrogenic activity. Compounds without a phenanthrene nucleus | Proceedings of the Royal...
In earlier publications the oestrogenic activity of a number of synthetic substances has been discussed. The first compounds to be tested contained the phenanthrene ring system, and it was shown (Cook, Dodds and Hewett 1933; Cook and Dodds 1933; Cook, Dodds, Hewett and Lawson 1934; Cook, Dodds and Greenwood 1934) that a high degree of activity is possessed by 9 : 10-dihydroxy-9 : 10-di-n-propyl-9 : 10-dihydro-1 : 2 : 5 : 6-dibenzanthracene. Potency was also observed in the highly unsaturated aliphatic acid, clupanodonic acid, whilst a feeble but definite oestrogenic action was found to be possessed by calciferol. Since neither of these compounds contains the phenanthrene ring system, it was considered that this was not essential for oestrogenic properties. A further interesting observation was made in the partial activity of 1-keto-1: 2: 3: 4: 5: 6: 7: 8-octahydroanthracene. This substance produced an advanced pro-oestrus, but full cornification could not be produced no matter how much of the ...
Effect of Model Sorptive Phases on Phenanthrene Biodegradation: Molecular Analysis of Enrichments and Isolates Suggests...Effect of Model Sorptive Phases on Phenanthrene Biodegradation: Molecular Analysis of Enrichments and Isolates Suggests...
The Yellowstone National Park Research Coordination Network is a collaboration of scientists and NPS staff to develop a coordinated research network focused on geothermal biology and geochemistry.
Most recent papers with the keyword Stress metabolic | Read by QxMDMost recent papers with the keyword Stress metabolic | Read by QxMD
Mounting evidence has strongly implicated oxidative stress in the development of cardiac dysfunction, and myocardial apoptosis contributes to the pathogenesis of heart failure. Quantitative cardiac proteomics data revealed that pressure load by TAC resulted in a significant decline in mitochondrial metabolic activity, where TIIA (Tanshinone IIA sulfonate) treatment reversed it in vivo, which might be mediated by Nrf2. In NRVMs, TIIA treatment ameliorated H2O2-induced caspase-3/9 activations through the suppression of p38 and mTOR signaling pathways, where caspase-mediated cleavage of YY1 and PARP resulted in the defects in mitochondrial biogenesis and DNA repair, and this event finally led to cardiomyocyte apoptosis ...
Welcome to Wen Jiang GroupWelcome to Wen Jiang Group
Jiang, W., Zhao, Y., Xu, T., Zhao, B. L., Hou, J. W., Ma, G. E., Lu, X. Z., and Xin, W. J. 1996. Effects of sodium tanshinone iia sulfate on mitochondrial electron transport chain: A preliminary study. in: Proceedings of the international symposium on natural antioxidants: molecular mechanism and health effects. Packer, L., Traber, M. G., and Xin, W. J., eds., Beijing, AOCS Press, Champaign, Illinois. ...
Structure and antifungal activity of hircinol, loroglossol and orchinolStructure and antifungal activity of hircinol, loroglossol and orchinol
Author(s): Fisch, MH; Flick, BH; Arditti, J | Abstract: The structure of hircinol, a phytoalexin isolated from Loroglossum hircinum has been established as 2, 5-dihydroxy-4-methoxy-9,10-dihydrophenanthrene. This phytoalexin, the second to be identified in the Orchidaceae, is less effective than orchinol, and its isomeric co-metabolite, loroglossol, 5-hydroxy-2,4-dimethyoxy-9,10-dihydrophenanthrene, is inactive. © 1973.
Validation of data on polycyclic biomarkers, naphthalenes, phenanthrenes, and alkyldibenzothiophenes obtained by gas...Validation of data on polycyclic biomarkers, naphthalenes, phenanthrenes, and alkyldibenzothiophenes obtained by gas...
The possibility of using the data on the hydrocarbon composition obtained by analysis of hydrocarbon concentrates for geochemical studies has been shown on the example of Pannonian Basin (Serbia) crude oils of different genetic types and different degrees of thermal maturity and biodegradation. A high convergence of the values of geochemical parameters calculated on the basis of the composition of steranes and terpanes, alkylnaphthalenes, phenanthrenes, and dibenzothiophenenes in hydrocarbon concentrates and chromatographic fractions isolated from them has been found by correlation analysis ...
CSEMP assessment of c1 phenanthrenes in sediment at station Clyde FirthCInnerCumbraes se02CSEMP assessment of c1 phenanthrenes in sediment at station Clyde FirthCInnerCumbraes se02
Clean Seas Environment Monitoring Programme (CSEMP) accessment of c1 phenanthrenes in sediment (unsieved) at station Clyde_FirthCInnerCumbraes_se02, Skelmorlie (Clyde) from the Marine Environment Monitoring and Assessment National database (MERMAN).
DiVA - Search resultDiVA - Search result
Electric current is known to flow through the π-bonds in oligothiophenes. In order to use them as molecular wires it is important to use a technique where the potential gradients can be generated and maintained in supramolecular networks. A solution to this problem can be the use of metal complexes as junction points within such a network.. In this project pathways to synthesize 2-thia-7,8-diaza-cyclopenta[l]phenanthrene (1) and 1-thia-7,8-diaza-cyclopenta[l]phenanthrene (2) for use in molecular electronic devices have been investigated. 4-(5-Bromo-thiophen-2-yl)2,2-bipyridine (3) was prepared via Kröhnke reaction from 3-(5-bromothiophene-2-yl)acrolein and 1-(2-Oxo-2-pyridine-2-yl-ethyl)-pyridinium iodide in an overall yield of 14 %. Several routes towards 2-thia-7,8-diaza-cyclopenta[l]phenanthrene (1) and 1-thia-7,8-diaza-cyclopenta[l]phenanthrene (2) were tested. Since the original planned pathway did not work, lack of time made it impossible to complete the series of experiments that were ...
ChemIDplus - 159092-80-5 - CZXWGQHRIOYVGI-UHFFFAOYSA-N - Phenanthrene, 2,5,10-trinitro- - Similar structures search, synonyms,...ChemIDplus - 159092-80-5 - CZXWGQHRIOYVGI-UHFFFAOYSA-N - Phenanthrene, 2,5,10-trinitro- - Similar structures search, synonyms,...
159092-80-5 - CZXWGQHRIOYVGI-UHFFFAOYSA-N - Phenanthrene, 2,5,10-trinitro- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Carcinogen Metabolites as Biomarkers<...Carcinogen Metabolites as Biomarkers<...
TY - CHAP. T1 - Carcinogen Metabolites as Biomarkers. AU - Hecht, Stephen S.. PY - 2008/4/22. Y1 - 2008/4/22. KW - 1-Hydroxypyrene (1-HOP). KW - Carcinogen metabolism and carcinogen metabolite biomarker use. KW - Carcinogen metabolite biomarkers. KW - Gas chromatography with nitrosamine-selective detection (GC-TEA). KW - Heterocyclic aromatic amines. KW - Metabolic detoxification. KW - Phenanthrene metabolites. KW - Prototypic polycyclic aromatic hydrocarbon (PAH). UR - http://www.scopus.com/inward/record.url?scp=84865448168&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84865448168&partnerID=8YFLogxK. U2 - 10.1002/9780470725726.ch8. DO - 10.1002/9780470725726.ch8. M3 - Chapter. AN - SCOPUS:84865448168. SN - 9780470027431. SP - 97. EP - 110. BT - Molecular Epidemiology of Chronic Diseases. PB - John Wiley and Sons. ER - ...
Triptolide promotes senescence of prostate cancer cells through induction of histone methylation and heterochromatin formationTriptolide promotes senescence of prostate cancer cells through induction of histone methylation and heterochromatin formation
Background: Triptolide is a medicinal herb-derived diterpene triepoxide with potent anti-tumor activity against a wide range of tumors. The anti-tumor mechanism of this small molecule has been correlated mainly with its ability to inhibit and inactivate subunits of RNA polymerase II, thereby suppressing global gene transcription. Epigenetic imbalance including histone methylation are well known to play important role in Prostate cancer (PCa) onset and progression. The goal of this study was to investigate whether Triptolide performs its anti-PCa activities by reshaping the histone methylation landscape in PCa cells.Methods: Triptolide-treated PCa cell lines were analyzed by RT-qPCR and western blotting to measure the expression of histone methylases; demethylases and associated histone marks. Detection of senescence was done using Senescence Associated β-Galactosidase Staining. Apoptosis and cell cycle analysis were performed by flow cytometry. Senescence -associated heterochromatine foci were detected
Cheryl Zimmerman, RPh, PhD | School of Dentistry - University of MinnesotaCheryl Zimmerman, RPh, PhD | School of Dentistry - University of Minnesota
Jing Wang, Yan Zhong, Steven G Carmella, J Bradley Hochalter, Diane Rauch, Andrew Oliver, Joni Jensen, Dorothy K Hatsukami, Pramod Upadhyaya, Stephen S Hecht and Cheryl Zimmerman. Phenanthrene metabolism in smokers: use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation. J Pharmacol Exp Ther 342(3): 750-60, 2012. (e-published June 6, 2012) PMID: ...
Transformation and mineralization of benzo[«03B1»]pyrene by microbial cultures enriched on mixtures of three- and four-ring...Transformation and mineralization of benzo[«03B1»]pyrene by microbial cultures enriched on mixtures of three- and four-ring...
Microorganisms originating from a soil contaminated by low levels of polycyclic aromatic hydrocarbons (PAHs) were enriched with three- and four-ring PAHs as primary substrates in the presence of benzo[a]pyrene (BaP). Most enrichment cultures, isolated in the presence or absence of a sorptive matrix, significantly transformed BaP. Evidence of BaP mineralization was obtained with cultures enriched on phenanthrene and anthracene. Our findings supplement literature data suggesting the wide occurrence of microbial activity against BaP. ...
Biodegradation of PAHs by Acinetobacter isolated from karst groundwater in a coal-mining area | springerprofessional.deBiodegradation of PAHs by Acinetobacter isolated from karst groundwater in a coal-mining area | springerprofessional.de
A bacterial strain Acinetobacter sp. WSD with phenanthrene-degrading ability was identified based on biochemical tests and 16S rDNA gene sequence …
Supplementary Components1. sediment-cap interface with the application of voltage than in - Extracellular ATP inhibits chloride...Supplementary Components1. sediment-cap interface with the application of voltage than in - Extracellular ATP inhibits chloride...
Supplementary Components1. sediment-cap interface with the application of voltage than in controls. Vertical profiles of phenanthrene porewater focus were attained by PDMS-coated dietary fiber, and results demonstrated that phenanthrene at the depth of 0-0.5 cm below the anode was degraded to ~70% of the original concentration within 10 weeks. PAH degrading genes showed a rise of around 1 purchase of magnitude at the same depth. The no power handles demonstrated no degradation of PAH. These results claim that electrode improved capping may be used to control redox potential, offer microbial electron acceptor, and stimulate PAH degradation. of 8912.18 For all PDMS analyses, the technique described by Lu18 was used. The dietary fiber was cleaned ahead of MLN2238 kinase inhibitor deployment by sonication in hexane for at the least around 30 minutes, accompanied by a wash with acetone and deionized drinking water. After a day of equilibration of the fibers with the sediment, fibers had been rinsed ...
Enhancing Phenanthrene Biomineralization in a Polluted Soil Using Gaseous Toluene as a CosubstrateEnhancing Phenanthrene Biomineralization in a Polluted Soil Using Gaseous Toluene as a Cosubstrate
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GMD - phenanthrene - InChI=1S/C14H10/c1-3-7-13-11(5-1)9-10-12-6-2-4-8-14(12)13/h1-10HGMD - phenanthrene - InChI=1S/C14H10/c1-3-7-13-11(5-1)9-10-12-6-2-4-8-14(12)13/h1-10H
The Golm Metabolome Database (GMD) facilitates the search for and dissemination of mass spectra from biologically active metabolites quantified using GC-MS.
Phenanthrene, 3-ethylPhenanthrene, 3-ethyl
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Teen Ink | phenanthreneTeen Ink | phenanthrene
Im younger then i act and older than i look. I have a boyfriend and live with my mum and sis, i speak english and french. I enjoy talking in short, robotic sentances. Oh well im not very good at about me descriptions.
Phenanthrene, 3,10-dimethylPhenanthrene, 3,10-dimethyl
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Structure/Reactivity Relationships in the Benzo[ c ]phenanthrene Skeleton: Stable Ion and Electrophilic Substitution ...Structure/Reactivity Relationships in the Benzo[ c ]phenanthrene Skeleton: Stable Ion and Electrophilic Substitution ...
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Health Services / Food AllergyHealth Services / Food Allergy
Học Khu yêu cầu phải thông báo khi học sinh có kết quả chuẩn đoán mắc một chứng bệnh bệnh dị ứng thực phẩm, đặc biệt là các chứng bệnh dị ứng có thể gây ra các phản ứng nguy hiểm hoặc các phản ứng đe dọa đến tính mạng. Điều quan trọng là quý vị cần liên lạc với y tá trường và thông báo loại thực phẩm mà học sinh bị dị ứng, cũng như tính chất của phản ứng đó. Ngoài ra, sau khi ghi danh, học sinh sẽ nhận được mẫu khai các chứng bệnh dị ứng. Quý vị cần phải điền và nộp lại mẫu điền này cùng với giấy tờ đăng ký nếu học sinh có một chứng bệnh liên quan tới dị ứng thực phẩm. Tuy nhiên, nếu học sinh được chẩn đoán là có một chứng bệnh dị ứng thực phẩm có thể gây ra phản ứng nguy hiểm hoặc đe dọa đến tính mạng, chứng bệnh của đứa trẻ sẽ ...
Thực phẩm chức năng - Collagen | sữa ong chúa | nhau thai cừuThực phẩm chức năng - Collagen | sữa ong chúa | nhau thai cừu
Cung cấp sỉ & lẻ các thực phẩm chức năng nhập khẩu từ Mỹ, Pháp , Anh. Cam kết hàng chính hãng - An toàn vệ sinh thực phẩm
Thực phẩm chức năng - Collagen | sữa ong chúa | nhau thai cừuThực phẩm chức năng - Collagen | sữa ong chúa | nhau thai cừu
Cung cấp sỉ & lẻ các thực phẩm chức năng nhập khẩu từ Mỹ, Pháp , Anh. Cam kết hàng chính hãng - An toàn vệ sinh thực phẩm
Bàn ghế cà phê giá rẻ giá 680.000 Đ - Thiết kế thi công nội thất, bàn ghế gỗ cho quán cafeBàn ghế cà phê giá rẻ giá 680.000 Đ - Thiết kế thi công nội thất, bàn ghế gỗ cho quán cafe
Bàn ghế cà phê giá rẻ giá 680.000 Đ, Chúng tôi chuyên cung cấp số lượng lớn các loại bàn ghế cà phê gỗ thông pallet, quầy bar, kệ trang trí
Poly-Aromatic HydrocarbonsPoly-Aromatic Hydrocarbons
PAH is an acronym for Poly-Aromatic Hydrocarbons (PAH), a chemical compound that contains more than one fused benzene ring. They are commonly found in petroleum fuels, coal products, and tar; e.g. Naphthalene, Anthracene, Phenanthrene
Cardiac effects of antimalarial treatment with halofantrine - MORU Tropical Health NetworkCardiac effects of antimalarial treatment with halofantrine - MORU Tropical Health Network
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Concept Questions for Chemistry using PhET - PhET ContributionConcept Questions for Chemistry using PhET - PhET Contribution
These are clicker questions that I use in Chemistry with PhET. Many could be used for any grade level. The questions could be used as a framework to modify for specific needs. I update this file as I add questions ...
Lenses and their Images - PhET příspěvekLenses and their Images - PhET příspěvek
Students will locate and describe the image that is seen through a lens, both with an actual lens and with the PHET simulation ...
Mondays Apoc-Eclipse Liveblog | PJ MediaMonday's Apoc-Eclipse Liveblog | PJ Media
Welcome to HOT MIC, PJ Medias daily liveblog. Join our editors and contributors for news updates and conversation throughout the day, and add your thoughts to the mix in our comments section at the bottom or by clicking on the comment bubbles on individual posts.  Be sure to save this ...
Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5 R )-5-hydroxytriptolide (LLDT-8)...Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5 R )-5-hydroxytriptolide (LLDT-8)...
The Chinese traditional herb Tripterygium wilfordii Hook f (TwHF) has been widely used in the treatment of autoimmune and inflammatory diseases. Over the past few decades, great efforts have been made to explore modern preparations of TwHF with higher efficacy, solubility, and lower toxicity. In this study, we reviewed several examples both of naturally occurring compounds and their derivatives in TwHF, and summarized the preclinical evaluations with regard to autoimmune and inflammatory diseases. All of the candidate compounds described herein have been or are currently in clinical trials. Although some studies encountered problems, the data still provided valuable references for future studies. (5R)-5-hydroxytriptolide (LLDT-8, Leitengshu) is a novel triptolide derivative with potent immunosuppressive and anti-inflammatory activities developed at Shanghai Institute of Materia Medica. Indeed, a Phase I clinical trial for this compound has been completed in rheumatoid arthritis patients. The results
The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook FThe Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F
Various preparations of Tripterygium wilfordii Hook F (TwHF) have been used in the treatment of a number of autoimmune and inflammatory diseases since the 1960s. Accumulated data from the clinical trials suggest efficacy of this treatment in a number of rheumatic diseases, including rheumatoid arthr …
China Tripterygium Wilfordii Extract, China Tripterygium Wilfordii Extract Manufacturers and Suppliers on Alibaba.comChina Tripterygium Wilfordii Extract, China Tripterygium Wilfordii Extract Manufacturers and Suppliers on Alibaba.com
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Molecular Evidence of Cryptotanshinone for Treatment and Prevention of Human Cancer | Bentham ScienceMolecular Evidence of Cryptotanshinone for Treatment and Prevention of Human Cancer | Bentham Science
Title:Molecular Evidence of Cryptotanshinone for Treatment and Prevention of Human Cancer. VOLUME: 13 ISSUE: 7. Author(s):Wenxing Chen, Yin Lu, Guangying Chen and Shile Huang. Affiliation:College of Pharmacy and Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210046, China.. Keywords:Cryptotanshinone, tanshinones, cancer, cell proliferation, cell death, mTOR.. Abstract:Cryptotanshinone is one of the major tanshinones isolated from the roots of the plant Salvia miltiorrhiza Bunge (Danshen). Danshen has been widely used in traditional Chinese medicine for treatment of a variety of diseases, including coronary artery disease, acute ischemic stroke, hyperlipidemia, chronic renal failure, chronic hepatitis, and Alzheimers disease, showing no serious adverse effects. Recent studies have shown that cryptotanshinone not only possesses the potential for treatment and prevention of the above-mentioned diseases, but ...
Inhibition of cell growth and nuclear factor-κB activity in pancreatic cancer cell lines by a tylophorine analogue, DCB-3503<...Inhibition of cell growth and nuclear factor-κB activity in pancreatic cancer cell lines by a tylophorine analogue, DCB-3503<...
TY - JOUR. T1 - Inhibition of cell growth and nuclear factor-κB activity in pancreatic cancer cell lines by a tylophorine analogue, DCB-3503. AU - Shiah, Her Shyong. AU - Gao, Wenli. AU - Baker, David C.. AU - Cheng, Yung Chi. PY - 2006/10/1. Y1 - 2006/10/1. N2 - A tylophorine analogue, DCB-3503, has been shown to have potent activity against tumor growth in vitro and in vivo, as well as activity in an autoimmune disease model in vivo. This study focuses on investigating the mechanisms responsible for antitumor activity of DCB-3503. The concentrations for inhibiting 50% growth/colony formation ability are 50/ 162 and 40/149 nmol/L for PANC-1 and HPAC cells, respectively. The growth inhibition effects are associated with DCB-3503-induced reprogramming of tumor cells. DCB-3503 could interfere w: th cell cycle progression. Several cell cycle regulatory proteins, including cyclin D1, are down-regulated by DCB-3503. Using several different transcription elements coupled with a reporter gene, it was ...
Tumorigenicity of 5-Methylchrysene Dihydrodiols and Dihydrodiol Epoxides in Newborn Mice and on Mouse Skin<...Tumorigenicity of 5-Methylchrysene Dihydrodiols and Dihydrodiol Epoxides in Newborn Mice and on Mouse Skin<...
TY - JOUR. T1 - Tumorigenicity of 5-Methylchrysene Dihydrodiols and Dihydrodiol Epoxides in Newborn Mice and on Mouse Skin. AU - Hecht, Stephen S.. AU - Radok, Lynn. AU - Amin, Shantu. AU - Huie, Keith. AU - Melikian, Assieh A.. AU - Hoffmann, Dietrich. AU - Pataki, John. AU - Harvey, Ronald G.. PY - 1985/4/1. Y1 - 1985/4/1. N2 - 5-Methylchrysene, (±-trans-1,2-dihydro-1,2-dihydroxy-5-methylchrysene, (±-trans-7,8-dihydro-7,8-dihydroxy-5-methyl-chrysene, (±)-trans-1,2-dihydroxy-anti-3,4-epoxy-1,2,3,4-tetra-hydro-5-methylchrysene (anti-DE-l), (±trans-1,2-dihydroxy-«yr?-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (syn-DE-l), and (±trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydro-5-methylchrysene (anti-DE-ll) were tested for tumorigenicity in newborn mice and for tumor-initiating activity on mouse skin. In newborn mice, a total dose of 56 nmol of anti-DE-l induced 4.6 lung tumors/mouse and 1.2 liver tumors/mouse. These incidences were significantly higher than observed for any of the ...
Tripterygium Wilfordii hook - EVIDENCE BASED NATURAL HEALTHTripterygium Wilfordii hook - EVIDENCE BASED NATURAL HEALTH
Pancreatic adenocarcinoma is characterized by a poor prognosis and lack of response to conventional therapy. The incidence has shown that no significant sign of decline throughout the past 20 years and almost equals its mortality[1-3]. The 5-year survival rate for this disease is less than 4% and the median survival time after diagnosis is less than 6 mo[2,3]. Surgical resection of the tumor is still the only effective treatment option, although only 20% of carcinomas of the head of the pancreas are resectable[4].Furthermore, the median survival even after apparent curative resection is only 20 mo, because of early tumor recurrence or rapid metastatic spread[2,4]. Other treatment options, such as chemotherapy or radiation therapy, provide limited palliation without significant improvement of survival in patients with unresectable pancreatic cancer[2]. Therefore; new targets for chemo-preventive and therapeutic agents need to be identified.Triptolide (TL), extracts of the Chinese herb ...
Characterization of a Polycyclic Aromatic Hydrocarbon Degradation Gene Cluster in a Phenanthrene-Degrading Acidovorax Strain |...Characterization of a Polycyclic Aromatic Hydrocarbon Degradation Gene Cluster in a Phenanthrene-Degrading Acidovorax Strain |...
Members of the Acidovorax genus are frequently encountered in association with PAH degradation, notably that of phenanthrene, but prior to this work little was known of the underlying genetic determinants behind the phenotype. The particular Acidovorax strain used in this study has genes very similar in sequence and arrangement to those in Alcaligenes faecalis AFK2, and the initial dioxygenase sequence is also highly similar to those in several Burkholderia strains, although not to that of Burkholderia sp. strain RP007. These observations suggest that this particular genotype may be widespread among some PAH-degrading members of the order Burkholderiales.. Unfortunately for comparative purposes, while the genes determined in this study bear significant resemblance to the Alcaligenes faecalis AFK2 sequences deposited in GenBank, there does not appear to be a publication associated with the entry (GenBank accession number AB024945). However, other previously published research on AFK2 revealed the ...
Healthy Plant Extract Tripterygium Wilfordii Extract 38748-32-2 High Purity - rawpowdersanabolicHealthy Plant Extract Tripterygium Wilfordii Extract 38748-32-2 High Purity - rawpowdersanabolic
Buy Healthy Plant Extract Tripterygium Wilfordii Extract 38748-32-2 High Purity direct from Pharmaceutical Raw Material of China Factory that provide Latest Pharmaceutical Raw Material - rawpowdersanabolic.
Tripterygium wilfordii | LewisGale Regional Health SystemTripterygium wilfordii | LewisGale Regional Health System
Learn more about Tripterygium wilfordii at LewisGale Regional Health System Thundergod Vine, Lei Gong Teng Uses Principal Proposed Uses ...
Tripterygium wilfordii tablets in the treatment of active ankylosing spondylitis: a randomized double-blind, placebo-controlled...Tripterygium wilfordii tablets in the treatment of active ankylosing spondylitis: a randomized double-blind, placebo-controlled...
This trial will assess the efficacy of tripterygium wilfordii Hook-F in patients with active ankylosing spondylitis. The primary endpoints are immunoglobulin A,
Tripterygium wilfordii | Doctors HospitalTripterygium wilfordii | Doctors Hospital
Learn more about Tripterygium wilfordii at Doctors Hospital of Augusta Thundergod Vine, Lei Gong Teng Uses Principal Proposed Uses Rheumatoid...
The use of directional traps for the assessment of short-term phenanthrene effects upon soil springtail communities. - Jean...The use of directional traps for the assessment of short-term phenanthrene effects upon soil springtail communities. - Jean...
The use of directional traps for the assessment of short-term phenanthrene effects upon soil springtail communities. : In: Environmental Pollution, 2006, 140 (2), pp.364-370. Directional traps, both horizontal and vertical, were used to assess the behavioural impact of phenanthrene application on soil springtail communities. Avoidance was not detected. Rather, a vertical attraction of the dominant species, Folsomia manolachei, was demonstrated, as well as a decrease in horizontal movements of Lepidocyrtus
Plus itPlus it
5459 Triptolide (TPL), a diterpenoid triepoxides-like small molecule purified from Tripterygium wilfordii Hook F., has been used as an anti-tumor and anti-inflammation agent with very promising results from clinical trails. For the better targeting on tumor and the reducing of TPL toxicity, the improvement of deliver formula of TPL is needed. Four forms of TPL Nan vehicles were prepared as follow: 1) TPL-PEG-Lip, which was made by enrapture of TPL in liposome (Lip) with 1,2-Dipalmitoyl-sn-Glycero-3-Phosphoethanolamine-N-[Amino (Polyethylene Glycol) 2000] (H2N-PEG-DPPE); 2) TPL-Fol-PEG-Lip, which utilized the folate to enhance the targeting ability to tumor cells via the over-expressed folate receptors; 3) TPL-Transferrin-Lip, which utilized the transferrin to target tumor cells via transferring receptors; and 4) TPL-hyaluronan (HA)-Lip, which utilized the hyaluronan as ligand for CD44 over-expressed on surface of tumor cells. The effects of different TPL nanovehicles on the tumor cell growth ...
Celastrol pretreatment as a therapeutic option against cisplatin-induced nephrotoxicity | AVESİSCelastrol pretreatment as a therapeutic option against cisplatin-induced nephrotoxicity | AVESİS
Celastrol is a natural bioactive compound extracted from the medicinal plant Tripterygium wilfordii Hook F. It exhibits immunosuppressive, anti-inflammatory, and antioxidant activities. Cisplatin is a commonly used chemotherapeutic drug in the treatment of a wide range of tumors. Although very effective therapeutically, it can cause nephrotoxicity leading to dose reduction or discontinuation of treatment. This study aims to clarify the therapeutic potential of celastrol in cisplatin-induced nephrotoxicity. The possible protective effects of celastrol pretreatment against cisplatin-induced oxidative stress and genotoxicity were investigated. A rat kidney epithelial cell line NRK-52E was pretreated with the desired concentrations of celastrol (200 nM, 100 nM, and 50 nM) for 24 h. The cells were treated with 50 mu M cisplatin for a further 24 h to see whether cisplatin caused the same or less toxicity compared to the vehicle control group. Alkaline comet assay was performed for genotoxicity ...
Transition Metal Complexes of Phenanthrenequinone Thiosemicarbazone as by Zahra Afrasiabi Navan, Ekkehard Sinn et al."Transition Metal Complexes of Phenanthrenequinone Thiosemicarbazone as" by Zahra Afrasiabi Navan, Ekkehard Sinn et al.
The thiosemicarbazone derivative of 9,10-phenanthrenequinone, 1, and its metal complexes were synthesized. The X-ray crystal structure for 1 confirms the presence of the E tautomeric arrangement in this compound. Its copper complex shows 1:1 stoichiometry while nickel and cobalt compounds show 1:2 stoichiometry. The X-ray crystal structure of the nickel complex indicates two tridentate ligands coordinating in the thiolato form yielding an octahedral geometry for the mer isomer. The copper complex exhibits maximum antiproliferative activity against human breast cancer cell-line, T47D probably due to inhibition of steroid binding to the cognative receptor or by preventing dimerization of the estrogen receptor.
Tanshinone IIA sulfonic sodiumTanshinone IIA sulfonic sodium
Background Adverse wellness effects of cigarette smoke cigarettes arise partly from its impact about innate and adaptive immune system responses resulting in impaired innate immunity and sponsor defense. after an individual initial OVA problem and/or acrolein publicity on day time 14 or 48?hrs following the last OVA problem on day time 18. Inflammatory cells and Th1/Th2 cytokine amounts were assessed in BALF and Tanshinone IIA sulfonic sodium lung cells samples were gathered for evaluation of mucus and Th1/Th2 cytokine manifestation determination of proteins alkylation mobile thiol position and transcription element activity. Results Contact with acrolein pursuing OVA problem of OVA-sensitized mice led to markedly attenuated sensitive airway inflammation proven by reduced inflammatory cell infiltrates mucus hyperplasia and Th2 cytokines. Acrolein publicity quickly depleted lung cells glutathione (GSH) amounts and induced activation from the Nrf2 pathway indicated by build up of Nrf2 improved ...
EP2-PKA signaling is suppressed by triptolide in lipopolysaccharide-induced microglia activation | Journal of Neuroinflammation...EP2-PKA signaling is suppressed by triptolide in lipopolysaccharide-induced microglia activation | Journal of Neuroinflammation...
Microglia are key players for the inflammatory responses in the central nervous system. Suppression of microglial activation and the resulting production of proinflammatory molecules are considered a promising strategy to alleviate the progression of neurodegenerative disorders. Triptolide was demonstrated as a potent anti-inflammatory compound both in vitro and in vivo. The present study explored potential signal pathways of triptolide in the lipopolysaccharide (LPS)-induced inflammatory response using primary rat microglial cells. Microglial cells were pretreated with triptolide and stimulated with LPS. To investigate the anti-inflammatory effect of triptolide, we used Griess reagent and Western blot for NO release and iNOS expression, respectively. Moreover, we applied microglia-conditioned medium to neuronal cells and used the MTS assay to test cell viability. We found that triptolide inhibited LPS-induced NO and iNOS synthesis in microglial cells, which in turn protected neurons. To evaluate the
Characterization of an alkylammonium-montmorillonite-phenanthrene...: Ingenta ConnectCharacterization of an alkylammonium-montmorillonite-phenanthrene...: Ingenta Connect
Low molecular weight polycyclic aromatic hydrocarbons can intercalate from the solid phase into montmorillonite (Mt) saturated with quaternary alkylammonium ions. However, the interaction and relationship between guest and host organic molecules in the interlayer space of the clay are not well understood. We have intercalated phenanthrene into tetradecyltrimethylammonium (TDTMA)-montmorillonite by a solid-solid reaction. The basal spacing of the original TDTMA-Mt complex is close to 1.8 nm, indicating the presence in the interlayer space of a double layer of TDTMA ions with the alkyl (polymethylene) chains lying parallel to the silicate layers, and the carbon zig-zags adopting an all-trans conformation. After intercalation of phenanthrene the basal spacing increases to about 3.4 nm, indicating a change in orientation of the alkyl chains with respect to the silicate layers. 13C-NMR spectroscopy shows that adding phenanthrene to TDTMA-Mt leads to a displacement by -3 ppm of the -(CH2)n - signal ...
Lei Gong Teng (Radix Tripterygium wilfordii) - Health ArticlesLei Gong Teng (Radix Tripterygium wilfordii) - Health Articles
Lei Gong Teng is also known as Thunder god vine. The bitter and very toxic herb has been used in TCM as an anti-inflammatiory and immunosuppressive agent and to resolve toxins, treat proteinuric renal disease, etc., as it expels Wind-Damp, resolves edema, calms pain, etc., by enhancing the functions of Liver and kidney channels. Ingredients …. ...
The effect of tripterygium wilfordii polyglycosidium on the compound action potential of skeletal muscle in experimental...The effect of tripterygium wilfordii polyglycosidium on the compound action potential of skeletal muscle in experimental...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
e0094 Research of triptolide on Ang II-induced neonatal cardiac fibroblasts proliferation and collagen synthesis | Hearte0094 Research of triptolide on Ang II-induced neonatal cardiac fibroblasts proliferation and collagen synthesis | Heart
Results 1. The proliferation of CFb is significantly promoted after adding Ang II, compared with the control group (p,0.05 or p,0.01). The 100 μg/l TP showed the effect of inhibiting the proliferation of CFb at the first 24 h (p,0.01), reached a peak within 48 h (p,0.001), started to diminish after 72 h, indicate the best time to exert effects were at 2 to 3 days. 2. With the time increase after adding Ang II, collagen synthesis increased, there is significant difference compared with the control group (p,0.05 or p,0.01). After 24 h, 48 h, 72 h of adding TP, the collagen content of each group compared with the Ang II group were significantly different. The effect of high concentration TP (100 μg/l) reached the peak (p,0.001) at 48 h (p,0.001). 3. After 24 h of adding Ang II, TGF-β1 expression was significantly increased (p,0.01). After 24 h of adding different concentrations of TP, TGF-β1 expression were significantly decreased (p,0.05 or p,0.01). 4. After 30min of adding Ang II, ERK1/2 ...
Chinese Plant CompoundChinese Plant Compound
... , Triptolide Wipes out Cancer in 40 Days, Say new Research. Triptolide is a diterpenoid epoxide found in the Thunder God Vine, Tripterygium wilfordii. It has in vitro and in vivo activities againstmouse models of polycystic kidney disease[1] and http://en.wikipedia.org/wiki/Pancreatic_cancer” rel="nofollow",pancreatic cancer, but its physical properties limit its therapeutic potential.[2] Consequently, a synthetic prodrug, minnelide, … Continue reading →. ...
Wipes outWipes out
Chinese Plant Compound , Triptolide Wipes out Cancer in 40 Days, Say new Research. Triptolide is a diterpenoid epoxide found in the Thunder God Vine, Tripterygium wilfordii. It has in vitro and in vivo activities againstmouse models of polycystic kidney disease[1] and http://en.wikipedia.org/wiki/Pancreatic_cancer” rel="nofollow",pancreatic cancer, but its physical properties limit its therapeutic potential.[2] Consequently, a synthetic prodrug, minnelide, … Continue reading →. ...
Antidiabetes and Antiobesity Effect of the Cryptotanshinone in Danshen tea | superhumangearAntidiabetes and Antiobesity Effect of the Cryptotanshinone in Danshen tea | superhumangear
Abstract Metabolic disorders, including type 2 diabetes and obesity, represent major health risks in industrialized countries. AMP-activated protein kinase (AMPK) has become the focus of a great deal of attention as a novel therapeutic target for the treatment of metabolic syndromes, because AMPK has been demonstrated to mediate, at least in part, the effects of…
wholesale Tanshinone IIA 40%,bulk price $0.00/kg;Herbal & Plant Extracts Supplier-eBioChem.comwholesale Tanshinone IIA 40%,bulk price $0.00/kg;Herbal & Plant Extracts Supplier-eBioChem.com
Appearance:red-brown powder or cherry red crystal powder;Sources:Dry roots;MOQ:1KG;Specification:40% ;Physical Appearance: red-brown powder or cherry red crystal powderMeasure method: HPLCPaking speci
HKU Scholars Hub: Inhibition of synovial fibroblast production of IL-6 by triptolide, an active ingredient of Trypterygyium...HKU Scholars Hub: Inhibition of synovial fibroblast production of IL-6 by triptolide, an active ingredient of Trypterygyium...
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1027-3948&volume=22&issue=Supp 2&spage=25&epage=&date=2000&atitle=Inhibition+of+synovial+fibroblast+production+of+IL-6+by+triptolide,+an+active+ingredient+of+Trypterygyium+Wilfordii+hook+ ...
Pharmacokinetic changes of halofantrine in experimentally-induced diabetes mellitus following oral drug administration |...Pharmacokinetic changes of halofantrine in experimentally-induced diabetes mellitus following oral drug administration |...
It was hypothesized in this study that alterations in plasma lipoprotein profile and disturbed gastrointestinal motility as observed in diabetes mellitus may influence the disposition of halofantrine (HF), a highly lipophilic antimalarial drug. Therefore, using a rat model of diabetes mellitus induced by administration of alloxan monohydrate, the effects of the disease on the pharmacokinetics of HF was investigated. Also, the drug binding to normal and diabetic plasma components was determined. Results showed that the mean Cmax values of HF and its major metabolite, desbutylhalofantrine (DHF), were markedly higher (up to 2.5 times) in the control than in diabetic rats (p , 0.05). Also, the early AUC (AUC0 - 12) and rate of drug absorption (Cmax /AUC0-) were markedly reduced by 40 and 58%, respectively, in diabetic compared to control group. However, the Tmax, AUC0-, and elimination T1/2 of HF were comparable between the two groups (p , 0.05). The binding of HF and DHF in diabetic plasma was ...
18-Norabietane - Wikipedia18-Norabietane - Wikipedia
18-Norabietane is a diterpene perhydrogenated phenanthrene derivative. It occurs in the mineral fichtelite. Ruzicka, L.; Balas, Fr.; Schinz, H. (1923). "Higher terpene compounds. XII. Fichtelite and the stereochemistry of hydrogenated phenanthrene derivatives". Helvetica Chimica Acta. 6: 692-697. doi:10.1002/hlca.19230060174 ...
Experimental and Therapeutic MedicineExperimental and Therapeutic Medicine
Authors: Zhang J, Guan Y, He L, Tao L, Zang Z, Zhu W, Chen L, Jin C Abstract Topical administration of triptolide (TP) is effective in the treatment of rheumatoid arthritis (RA), but it can also induce skin irritation. Previous studies have used data mining strategies to analyze the application of Tripterygium wilfordii in the treatment of RA and have shown that TP and ferulic acid (FA) can be used in combination due to their component compatibility. The aims of the present study were to investigate the mechanisms underlying the effects of TP treatment and to identify its effects on metabolism and oxidative damage ...
CCCC 1990, Volume 55, Issue 1, Abstracts pp. 245-255 | Collection of Czechoslovak Chemical CommunicationsCCCC 1990, Volume 55, Issue 1, Abstracts pp. 245-255 | Collection of Czechoslovak Chemical Communications
The synthesis and geometry of (Z)- and (E)-oximes, II and III, derivatives of tetrahydro-2H-benzo[d][1,2,3]triazoles and tetrahydrobenzo[c][1,2,5]oxadiazoles, was investigated. The possibility of structural assignments of II and III by Beckmann rearrangement was examined. Some CNDO/2 calculations were also carried out on the oximes II and III.. ...
A3PJ-5703-24E Omron Automation and Safety | Switches | DigiKeyA3PJ-5703-24E Omron Automation and Safety | Switches | DigiKey
Order Omron Automation and Safety A3PJ-5703-24E (Z6913-ND) at DigiKey. Check stock and pricing, view product specifications, and order online.
Plymouth Marine Science Electronic Archive (PlyMSEA)Plymouth Marine Science Electronic Archive (PlyMSEA)
Pipe, RK; Moore, MN. 1986 An Ultrastructural-Study On The Effects Of Phenanthrene On Lysosomal Membranes And Distribution Of The Lysosomal-Enzyme Beta-Glucuronidase In Digestive Cells Of The Periwinkle Littorina-Littorea. Aquatic Toxicology, 8 (1). 65 - 76. 10.1016/0166-445X(86)90073-1 Full text not available from this repository ...
1,3,4,5-Tetrahydroxy-2-methoxy-7-methylanthracene-9,10-dione - Alfa Chemistry1,3,4,5-Tetrahydroxy-2-methoxy-7-methylanthracene-9,10-dione - Alfa Chemistry
1,3,4,5-Tetrahydroxy-2-methoxy-7-methylanthracene-9,10-dione/ACM7229698 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
PQR | (3beta,7beta,12beta,25s)-3,7,12,20-tetrahydroxy-11,15,23-trioxolanost-8-en-26-oic acidPQR | (3beta,7beta,12beta,25s)-3,7,12,20-tetrahydroxy-11,15,23-trioxolanost-8-en-26-oic acid
You are viewing an interactive 3D depiction of the molecule (3beta,7beta,12beta,25s)-3,7,12,20-tetrahydroxy-11,15,23-trioxolanost-8-en-26-oic acid (C30H44O9) from the PQR.
IPNI Plant Name Query ResultsIPNI Plant Name Query Results
You searched on: Genus = Tripterygium and Ranks = gen and Hybrids only = false Found 1 record. Edit search View these results in delimited format: classic, minimal, short, extended ...
PJ Patong Resortel, Phuket (Patong Beach)PJ Patong Resortel, Phuket (Patong Beach)
PJ Patong Resortel, Patong Beach from 45 $ (22.Feb) Instant hotel booking. PJ Patong Resortel boasts a convenient location in Phukets most livable district. It has easy access to the citys major attraction. The best sho...
PhenanthrenoidPhenanthrenoid
FlickingeriaFlickingeria
Dendrobium plicatileDendrobium plicatile
Dendrobium nobileDendrobium nobile
GlaucineGlaucine
Polycyclic aromatic hydrocarbonPolycyclic aromatic hydrocarbon
Monomeria barbataMonomeria barbata
AnalgesicAnalgesic
Acetylcholinesterase inhibitorAcetylcholinesterase inhibitor
Plicatol CPlicatol C
2,3-Dichloro-5,6-dicyano-1,4-benzoquinone2,3-Dichloro-5,6-dicyano-1,4-benzoquinone
Bulbophyllum vaginatumBulbophyllum vaginatum
AromatizationAromatization
DihydrostilbenoidDihydrostilbenoid
AnthraceneAnthracene
ChryseneChrysene
AromaticityAromaticity
1-hydroxy-2-naphthoate hydroxylase1-hydroxy-2-naphthoate hydroxylase
CoeloginanthrinCoeloginanthrin
CyanonickelateCyanonickelate
Eria carinataEria carinata
Coelogyne cristataCoelogyne cristata
Bisphenol ABisphenol A
GABAA receptor positive allosteric modulatorGABAA receptor positive allosteric modulator
7-Hydroxy-2,3,4,8-tetramethoxyphenanthrene7-Hydroxy-2,3,4,8-tetramethoxyphenanthrene
18-Norabietane18-Norabietane
Juncus effususJuncus effusus
OpiumOpium
Bulbophyllum reptansBulbophyllum reptans
Cirrhopetalum maculosumCirrhopetalum maculosum
OrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureHealth Care
PhenanthrenesPolycyclic Hydrocarbons, AromaticBiodegradation, EnvironmentalSoil PollutantsPyrenesDelftiaPolycyclic CompoundsPolyporusSphingomonasPolyporaceaePolyporalesBay-Region, Polycyclic Aromatic HydrocarbonHumic SubstancesSoil MicrobiologyNaphthalenesChrysenesHydrocarbons, AromaticAnthracenesNaphtholsDioxygenasesDendrobiumHydrocarbonsGonanesButylaminesStereoisomerismBasidiomycotaEpoxy CompoundsDNA AdductsMucoralesCreosoteGram-Negative Aerobic BacteriaPoloxaleneFluorenesDioscoreaBromine CompoundsBiotransformationAdsorptionPetroleumRalstoniaWater Pollution, ChemicalMycobacteriumMutagensLigninGas Chromatography-Mass SpectrometryBurkholderiaSphingomonadaceaePseudomonasCarcinogensOxygenasesHydroponicsBiphenyl CompoundsBacteriaAnnonaceaeMutagenicity TestsAporphinesBenzo(a)pyreneAzaguanine
phenanthrene (CHEBI:28851)phenanthrene (CHEBI:28851)
PhenanthrenePhenanthrene
PhenanthrenePhenanthrene
Phenanthrene - WikipediaPhenanthrene - Wikipedia
Benzo(c)phenanthrene - WikipediaBenzo(c)phenanthrene - Wikipedia
Characterization of an alkylammonium-montmorillonite-phenanthrene...: Ingenta ConnectCharacterization of an alkylammonium-montmorillonite-phenanthrene...: Ingenta Connect
IUCr) 9,10-Di-iodo-phenanthreneIUCr) 9,10-Di-iodo-phenanthrene
Comparison of phenanthrene and pyrene degradation by different wood-decaying fungi. - PubMed - NCBIComparison of phenanthrene and pyrene degradation by different wood-decaying fungi. - PubMed - NCBI
Photocatalytic activity of Gd2O2CO3·ZnO·CuO nanocomposite used for the degradation of phenanthrene | SpringerLinkPhotocatalytic activity of Gd2O2CO3·ZnO·CuO nanocomposite used for the degradation of phenanthrene | SpringerLink
CSEMP assessment of c3 phenanthrenes in sediment at station Clyde FirthCInnerDunoon se06CSEMP assessment of c3 phenanthrenes in sediment at station Clyde FirthCInnerDunoon se06
CSEMP assessment of c1 phenanthrenes in sediment at station EScotland EScIntermediate se01CSEMP assessment of c1 phenanthrenes in sediment at station EScotland EScIntermediate se01
Correlation between Carcinogenicity and Chemical Structure in Cyclopenta[a]phenanthrenes | Cancer ResearchCorrelation between Carcinogenicity and Chemical Structure in Cyclopenta[a]phenanthrenes | Cancer Research
FLP reduction and hydroboration of phenanthrene o-iminoquinones and α-diimines - Dalton Transactions (RSC Publishing)FLP reduction and hydroboration of phenanthrene o-iminoquinones and α-diimines - Dalton Transactions (RSC Publishing)
Application of Cell Immobilization in Slurry-Phase Bioremediation: Phenanthrene Biodegradation and Detoxification | SpringerLinkApplication of Cell Immobilization in Slurry-Phase Bioremediation: Phenanthrene Biodegradation and Detoxification | SpringerLink
Mechanisms of metal-catalyzed cycloisomerizations of o-propargylbiaryls and o-allenylbiaryls to phenanthrenes: a DFT study -...Mechanisms of metal-catalyzed cycloisomerizations of o-propargylbiaryls and o-allenylbiaryls to phenanthrenes: a DFT study -...
Complete genome sequence of the phenanthrene-degrading soil bacterium Delftia acidovorans Cs1-4. - PubMed - NCBIComplete genome sequence of the phenanthrene-degrading soil bacterium Delftia acidovorans Cs1-4. - PubMed - NCBI
Frontiers | Isolation and Characterization of Phenanthrene Degrading Bacteria from Diesel Fuel-Contaminated Antarctic Soils |...Frontiers | Isolation and Characterization of Phenanthrene Degrading Bacteria from Diesel Fuel-Contaminated Antarctic Soils |...
EAWAG-BBD: Pathway Page, Phenanthrene (fungal 9R,10R)EAWAG-BBD: Pathway Page, Phenanthrene (fungal 9R,10R)
Phenanthrene (D10,98%)- CAS Number 1517-22-2Phenanthrene (D10,98%)- CAS Number 1517-22-2
Deuterated Phenanthrene Tetraol in Smokers Who Are at High Risk For Lung Cancer - Full Text View - ClinicalTrials.govDeuterated Phenanthrene Tetraol in Smokers Who Are at High Risk For Lung Cancer - Full Text View - ClinicalTrials.gov
Effects of plant species identity, diversity and soil fertility on biodegradation of phenanthrene in soilEffects of plant species identity, diversity and soil fertility on biodegradation of phenanthrene in soil
Effects of Soil/Sediment Organic Matter on the Desorption, Bioavailability, Sequestration, and Transformation of Phenanthrene |...Effects of Soil/Sediment Organic Matter on the Desorption, Bioavailability, Sequestration, and Transformation of Phenanthrene |...
Phenanthrene | 85-01-8Phenanthrene | 85-01-8
Metabolism of phenanthrene by the white rot fungus Pleurotus ostreatus. | Applied and Environmental MicrobiologyMetabolism of phenanthrene by the white rot fungus Pleurotus ostreatus. | Applied and Environmental Microbiology
Effects of Glucosinolate-Rich Broccoli Sprouts on Urinary Levels of Aflatoxin-DNA Adducts and Phenanthrene Tetraols in a...Effects of Glucosinolate-Rich Broccoli Sprouts on Urinary Levels of Aflatoxin-DNA Adducts and Phenanthrene Tetraols in a...
Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbonsUrinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons
Seasonal Biotransformation of Naphthalene, Phenanthrene, and Benzo[a]pyrene in Surficial Estuarine Sediments | Applied and...Seasonal Biotransformation of Naphthalene, Phenanthrene, and Benzo[a]pyrene in Surficial Estuarine Sediments | Applied and...
Plus itPlus it
DNA single strand breakage, DNA adducts, and sister chromatid exchange in lymphocytes and phenanthrene and pyrene metabolites...DNA single strand breakage, DNA adducts, and sister chromatid exchange in lymphocytes and phenanthrene and pyrene metabolites...
Molecular structure in relation to oestrogenic activity. Compounds without a phenanthrene nucleus | Proceedings of the Royal...Molecular structure in relation to oestrogenic activity. Compounds without a phenanthrene nucleus | Proceedings of the Royal...
OrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureHealth Care
PhenanthrenesPolycyclic Hydrocarbons, AromaticBiodegradation, EnvironmentalSoil PollutantsPyrenesDelftiaPolycyclic CompoundsPolyporusSphingomonasPolyporaceaePolyporalesBay-Region, Polycyclic Aromatic HydrocarbonHumic SubstancesSoil MicrobiologyNaphthalenesChrysenesHydrocarbons, AromaticAnthracenesNaphtholsDioxygenasesDendrobiumHydrocarbonsGonanesButylaminesStereoisomerismBasidiomycotaEpoxy CompoundsDNA AdductsMucoralesCreosoteGram-Negative Aerobic BacteriaPoloxaleneFluorenesDioscoreaBromine CompoundsBiotransformationAdsorptionPetroleumRalstoniaWater Pollution, ChemicalMycobacteriumMutagensLigninGas Chromatography-Mass SpectrometryBurkholderiaSphingomonadaceaePseudomonasCarcinogensOxygenasesHydroponicsBiphenyl CompoundsBacteriaAnnonaceaeMutagenicity TestsAporphinesBenzo(a)pyreneAzaguanine
Biodegradation of phenanthreneAnthraceneBenzoPAHsDegradation of phenanthreneDegrade phenanthrenePolycyclic aromatic hyHydrocarbonKineticsMetaboliteBioremediationRate of phenanthreneLevels of phenanthreneNaphthalene and phenanthreneFluoreneBenzeneDerivativesBioavailabilitySoilsSoilPyrene metabolitesMetabolitesUrineConcentrationMetabolismTetraolCompoundsAqueousPseudomonasChrysosporiumConcentrationsTotal radioactivitySynthesisCharacterizationPathwayMethanolRavatiteSymplasticSurfactantCytochromeArthrobacterSpectroscopyBacteriaFungusUptakeSole carbonFluorescence
Biodegradation of phenanthrene2
Anthracene6
Benzo7
PAHs9
Degradation of phenanthrene6
Degrade phenanthrene3
Polycyclic aromatic hy2
Hydrocarbon2
  • Residents of Qidong, People's Republic of China, are at high risk for development of hepatocellular carcinoma, in part due to consumption of aflatoxin-contaminated foods, and are exposed to high levels of phenanthrene, a sentinel of hydrocarbon air toxics. (aacrjournals.org)
  • A high convergence of the values of geochemical parameters calculated on the basis of the composition of steranes and terpanes, alkylnaphthalenes, phenanthrenes, and dibenzothiophenenes in hydrocarbon concentrates and chromatographic fractions isolated from them has been found by correlation analysis. (ac.rs)
Kinetics3
Metabolite3
Bioremediation1
  • This work highlights the possibility of using microbial fuel cells to achieve high degradation rates of phenanthrene through co-metabolism with concomitant electricity production and could potentially be utilised as an independent system or be integrated with other bioremediation technologies (e.g. pump and treat or permeable reactive barriers) to remediate petroleum hydrocarbons from contaminated subsurface environments or industrial effluents. (westminster.ac.uk)
Rate of phenanthrene2
  • Recipient(s) will receive an email with a link to 'The influence of a surfactant on the rate of phenanthrene mass transfer into water' and will not need an account to access the content. (iwaponline.com)
  • The rate of phenanthrene mineralization in this soil may be increased substantially through bioaugmentation with a bacterial inoculum. (elsevier.com)
Levels of phenanthrene1
Naphthalene and phenanthrene1
Fluorene1
Benzene1
  • Phenanthrene is nearly insoluble in water but is soluble in most low polarity organic solvents such as toluene, carbon tetrachloride, ether, chloroform, acetic acid and benzene. (wikipedia.org)
Derivatives3
Bioavailability1
  • We established enrichment cultures in which solid organic phases were used to reduce phenanthrene bioavailability to different degrees (R. J. Grosser, M. Friedrich, D. M. Ward, and W. P. Inskeep, Appl. (montana.edu)
Soils3
Soil13
Pyrene metabolites2
Metabolites2
Urine1
Concentration3
Metabolism2
Tetraol2
  • I. To determine the relationship between urinary deuterated ([D phenanthrene tetraol (PheT) level, PheT:phenanthrols (HOPhe) ratio, and the presence of bronchoepithelial metaplasia and/or dysplasia in smokers who have undergone screening bronchoscopy at Roswell Park Cancer Institute (RPCI). (clinicaltrials.gov)
  • Patients receive deuterated phenanthrene tetraol orally (PO). (clinicaltrials.gov)
Compounds3
Aqueous1
Pseudomonas2
  • A concentrated mineral-nutrient solution and a cell solution of Pseudomonas CRE7, a phenanthrene degrader, were added to the flasks. (epa.gov)
  • Mashreghi, M & Prosser, JI 2006, ' Survival and activity of Lux-marked phenanthrene-degrading Pseudomonas stutzeri P16 under different conditions ', Iranian Journal of Science and Technology Transaction A - Science , vol. 30, pp. 71-80. (elsevier.com)
Chrysosporium1
  • Circular dichroism spectra of the phenanthrene trans-9,10-dihydrodiol indicated that the absolute configuration of the predominant enantiomer was 9R,10R, which is different from that of the principal enantiomer produced by Phanerochaete chrysosporium. (asm.org)
Concentrations1
  • In a randomized, placebo-controlled chemoprevention trial, we tested whether drinking hot water infusions of 3-day-old broccoli sprouts, containing defined concentrations of glucosinolates, could alter the disposition of aflatoxin and phenanthrene. (aacrjournals.org)
Total radioactivity1
Synthesis1
Characterization1
Pathway1
Methanol1
Ravatite1
Symplastic1
  • Phenanthrene diffused through the cuticles of both species in 24-48 h, entering the epidermis to reside predominantly within the cell walls of maize (indicative of apoplastic transport) and the cellular cytoplasm of spinach (indicative of symplastic transport). (lancs.ac.uk)
Surfactant2
Cytochrome1
  • Significantly less phenanthrene trans-9,10-dihydrodiol was observed in incubations with the cytochrome P-450 inhibitor SKF 525-A (77% decrease), 1-aminobenzotriazole (83% decrease), or fluoxetine (63% decrease). (asm.org)
Arthrobacter1
Spectroscopy1
Bacteria3
  • Adsorption studies revealed that the anode (carbon) electrode has a high affinity for phenanthrene with 90% of the solute adsorbed in less than 3h.This suggests the carbon electrode could be used in co-localising petroleum contaminants in the environment while they are being degraded by electrochemically active bacteria iin the anode of a MFC. (westminster.ac.uk)
  • The availability of phenanthrene to bacteria declined in a biphasic double exponential pattern with time. (elsevier.com)
  • Shahriari Moghadam M, Ebrahimipour G, Abtahi B, Ghassempour A. Isolation, Identification and Optimization of Phenanthrene Degrading Bacteria From the Coastal Sediments of Nayband Bay, Jundishapur J Microbiol. (kowsarpub.com)
Fungus1
Uptake3
Sole carbon1
  • Strain Sphe3 is able to utilize phenanthrene as a carbon source at high rates and appears to internalize phenanthrene with two mechanisms: a passive diffusion when cells are grown on glucose, and an inducible active transport system when cells are grown on phenanthrene as a sole carbon source. (openarchives.gr)
Fluorescence1
Search | The Merck Index Online
Search | The Merck Index Online (rsc.org)
Phenanthrene (CHEBI:28851)
Phenanthrene (CHEBI:28851) (ebi.ac.uk)
Spatial and Temporal Variability of Polycyclic Aromatic Hydrocarbons in Sediments from Yellow River-Dominated Margin
Spatial and Temporal Variability of Polycyclic Aromatic Hydrocarbons in Sediments from Yellow River-Dominated Margin (hindawi.com)
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GABAA receptor positive allosteric modulator - Wikipedia (en.wikipedia.org)
Frontiers | Vasorelaxant and Hypotensive Effects of an Ethanolic Extract of Eulophia macrobulbon and Its Main Compound 1-(4′...
Frontiers | Vasorelaxant and Hypotensive Effects of an Ethanolic Extract of Eulophia macrobulbon and Its Main Compound 1-(4′... (frontiersin.org)
Relativistic effects in homogeneous gold catalysis | Nature
Relativistic effects in homogeneous gold catalysis | Nature (nature.com)
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Dextromethorphan | Harvard Catalyst Profiles | Harvard Catalyst (connects.catalyst.harvard.edu)
Oxymorphone - DrugBank
Oxymorphone - DrugBank (drugbank.ca)
LIPID MAPS® Lipidomics Gateway
LIPID MAPS® Lipidomics Gateway (lipidmaps.org)
Development of New Radical Cascades and Multi-Component Reactions | Springer for Research & Development
Development of New Radical Cascades and Multi-Component Reactions | Springer for Research & Development (rd.springer.com)
CEISAM->Equipe...
CEISAM->Equipe... (sciences.univ-nantes.fr)
Phenanthrene, 4-methyl
Phenanthrene, 4-methyl (webbook.nist.gov)
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Opioids: Allergy vs. Pseudoallergy (uspharmacist.com)
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Human Metabolome Database: Showing metabocard for Rheochrysin (HMDB0035931) (hmdb.ca)
Pain & HA; Exam 2 at Wilkes University - StudyBlue
Pain & HA; Exam 2 at Wilkes University - StudyBlue (studyblue.com)
Amarkand | Eulophia | Dioscorea | Immunomodulation
Amarkand | Eulophia | Dioscorea | Immunomodulation (ijpsonline.com)
Anti-fatigue effect of Amarkand on endurance exercise capacity in rats | BMC Complementary and Alternative Medicine | Full Text
Anti-fatigue effect of Amarkand on endurance exercise capacity in rats | BMC Complementary and Alternative Medicine | Full Text (bmccomplementalternmed.biomedcentral.com)
Pharmacology 2 Cheat Sheet by gwenw - Download free from Cheatography - Cheatography.com: Cheat Sheets For Every Occasion
Pharmacology 2 Cheat Sheet by gwenw - Download free from Cheatography - Cheatography.com: Cheat Sheets For Every Occasion (cheatography.com)
臺灣蘭科植物－石斛、連珠石斛與臺灣金線連之化學成分及藥理活性研究__臺灣博碩士論文知識加值系統
臺灣蘭科植物－石斛、連珠石斛與臺灣金線連之化學成分及藥理活性研究__臺灣博碩士論文知識加值系統 (ndltd.ncl.edu.tw)
Bamboo orchid, Arundina graminifolia : Philippine Medicinal Herbs / StuartXchange
Bamboo orchid, Arundina graminifolia : Philippine Medicinal Herbs / StuartXchange (stuartxchange.com)
WO2011035842A1 - Polymerizable compounds and their use in liquid-crystal displays - Google Patents
WO2011035842A1 - Polymerizable compounds and their use in liquid-crystal displays - Google Patents (patents.google.com)
Sulfonyl radical-enabled 6- endo-trig cyclization for regiospecific synthesis of unsymmetrical diaryl sulfones - Organic...
Sulfonyl radical-enabled 6- endo-trig cyclization for regiospecific synthesis of unsymmetrical diaryl sulfones - Organic... (pubs.rsc.org)
Methanol-to-olefins process over zeolite catalysts with DDR topology: effect of composition and structural defects on catalytic...
Methanol-to-olefins process over zeolite catalysts with DDR topology: effect of composition and structural defects on catalytic... (pubs.rsc.org)
Nalbuphine | Profiles RNS
Nalbuphine | Profiles RNS (profiles.umassmed.edu)
Opiates - Nationwide Medical Reivew
Opiates - Nationwide Medical Reivew (drugfreeworkplace.com)
Simple Accordion with CSS & jQuery by Soh Tanaka
Simple Accordion with CSS & jQuery by Soh Tanaka (orgsyn.org)
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Overexpression of DnWRKY29 in tobacco impaired plants tolerance to salt and drought stresses, Russian Journal of Plant... (deepdyve.com)
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US5709943A - Biological adsorption supports - Google Patents (patents.google.com)
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The Tox & The Hound - IS THIS ANYTHING? (emcrit.org)
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In honor of Philippe Garrigues | Springer for Research & Development (rd.springer.com)
Chemical, physical, profile and laboratory analysis oceanographic data collected aboard the Ferrel in the Gulf of Mexico from...
Chemical, physical, profile and laboratory analysis oceanographic data collected aboard the Ferrel in the Gulf of Mexico from... (data.nodc.noaa.gov)
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Opioid analgesic drugs and serotonin toxicity (syndrome): mechanisms, animal models, and links to clinical effects |... (link.springer.com)