Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
The transference of a part of or an entire liver from one human or animal to another.
The transference of a kidney from one human or animal to another.
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
A dead body, usually a human body.
Human artificial insemination in which the semen used is that of a man other than the woman's husband.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Transfer of preovulatory oocytes from donor to a suitable host. Oocytes are collected, fertilized in vitro, and transferred to a host that can be human or animal.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Elements of limited time intervals, contributing to particular results or situations.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Tissue, organ, or gamete donation intended for a designated recipient.
The transference of a heart from one human or animal to another.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Centers for collecting, characterizing and storing human blood.
The transfer of leukocytes from a donor to a recipient or reinfusion to the donor.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
The body location or part from which tissue is taken for TRANSPLANTATION.
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.
Transference of an organ between individuals of the same species or between individuals of different species.
A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Partial or total replacement of the CORNEA from one human or animal to another.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Excision of kidney.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
Excision of all or part of the liver. (Dorland, 28th ed)
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
The formation of one or more genetically identical organisms derived by vegetative reproduction from a single cell. The source nuclear material can be embryo-derived, fetus-derived, or taken from an adult somatic cell.
Consideration and concern for others, as opposed to self-love or egoism, which can be a motivating influence.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.
A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.
The transference of either one or both of the lungs from one human or animal to another.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The degree to which the blood supply for BLOOD TRANSFUSIONS is free of harmful substances or infectious agents, and properly typed and crossmatched (BLOOD GROUPING AND CROSSMATCHING) to insure serological compatibility between BLOOD DONORS and recipients.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
Prospective patient listings for appointments or treatments.
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.
An individual that contains cell populations derived from different zygotes.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The rate dynamics in chemical or physical systems.
Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.
The transference of a pancreas from one human or animal to another.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
Methods of implanting a CELL NUCLEUS from a donor cell into an enucleated acceptor cell.
Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
An encapsulated lymphatic organ through which venous blood filters.
A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)
EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
The return of a sign, symptom, or disease after a remission.
Veins which drain the liver.
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The process by which a tissue or aggregate of cells is kept alive outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Immunological rejection of tumor tissue/cells following bone marrow transplantation.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Single layer of large flattened cells covering the surface of the cornea.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
An institutional policy of granting authority to health personnel to perform procedures on patients or to remove organs from cadavers for transplantation unless an objection is registered by family members or by the patient prior to death. This also includes emergency care of minors without prior parental consent.
The immune responses of a host to a graft. A specific response is GRAFT REJECTION.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
The induction of prolonged survival and growth of allografts of either tumors or normal tissues which would ordinarily be rejected. It may be induced passively by introducing graft-specific antibodies from previously immunized donors, which bind to the graft's surface antigens, masking them from recognition by T-cells; or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
Disease having a short and relatively severe course.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
The process by which ELECTRONS are transported from a reduced substrate to molecular OXYGEN. (From Bennington, Saunders Dictionary and Encyclopedia of Laboratory Medicine and Technology, 1984, p270)
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
Inorganic oxides that contain nitrogen.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.
Pathological processes of the LIVER.
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
Progenitor cells from which all blood cells derive.
Proteins prepared by recombinant DNA technology.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
Partial or total replacement of all layers of a central portion of the cornea.
The transfer of energy of a given form among different scales of motion. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed). It includes the transfer of kinetic energy and the transfer of chemical energy. The transfer of chemical energy from one molecule to another depends on proximity of molecules so it is often used as in techniques to measure distance such as the use of FORSTER RESONANCE ENERGY TRANSFER.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
A type of FLUORESCENCE SPECTROSCOPY using two FLUORESCENT DYES with overlapping emission and absorption spectra, which is used to indicate proximity of labeled molecules. This technique is useful for studying interactions of molecules and PROTEIN FOLDING.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Established cell cultures that have the potential to propagate indefinitely.
Antibodies produced by a single clone of cells.
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
The privacy of information and its protection against unauthorized disclosure.
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
A social group consisting of parents or parent substitutes and children.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
The preparation of leukocyte concentrates with the return of red cells and leukocyte-poor plasma to the donor.
Transference of fetal tissue between individuals of the same species or between individuals of different species.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
Revealing of information, by oral or written communication.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The ultimate exclusion of nonsense sequences or intervening sequences (introns) before the final RNA transcript is sent to the cytoplasm.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
Nucleotide sequences located at the ends of EXONS and recognized in pre-messenger RNA by SPLICEOSOMES. They are joined during the RNA SPLICING reaction, forming the junctions between exons.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
The transfer of mammalian embryos from an in vivo or in vitro environment to a suitable host to improve pregnancy or gestational outcome in human or animal. In human fertility treatment programs, preimplantation embryos ranging from the 4-cell stage to the blastocyst stage are transferred to the uterine cavity between 3-5 days after FERTILIZATION IN VITRO.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Deoxyribonucleic acid that makes up the genetic material of viruses.
Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.
The landowner - the conservation easement donor - retains title to the property. Regardless of changes in ownership, however, ... the conservation easement runs with the title, thereby protecting the land in perpetuity, for example from inappropriate ...
Benefactors (donations $20,000.00 and over) and Major Donors ($5000.00 and over) are permanently acknowledged on all printed ... Proceeds from investments now fund prizes for the awards in perpetuity. ...
There are ethical issues to consider since many donors of objects typically expect the museum to care for them in perpetuity. ... While each museum has its own procedures for accessioning, in most cases it begins with either an offer from a donor to give an ... Common donor restrictions include requiring that an object always be exhibited, or that a collection stays together. However, ... It is in clear contravention of the donor's intentions and it is an integral part of an important collection.' He said it was ...
Serving the Greater Boston area, it is made up of some 1,100 separate charitable funds established by thousands of donors over ... such as supporting individual nonprofit organizations in perpetuity. Today the Foundation is the largest public charity and the ... Today, the Foundation and its donors make grants each year to hundreds of nonprofits in Greater Boston and across the country. ... Working in partnership with donors to achieve high-impact philanthropy; and Serving as a civic hub and center of information, ...
They are supported by a broad range of private as well as public donors and seek contributions primarily from inside the ... They are governed by local boards and build capital endowment with the aim to ensure funding capability in perpetuity. The ... They support more than 1,000 large donor clients, have £500m of endowed funds under their management, and every year around ... The website allows supporters and donors to search for and find small charities and voluntary organisations in their community ...
... principal is held in perpetuity and that the earnings from this original principal are allocated according to the donor's ... depending on university policy or donor preferences. Some universities will facilitate donors' meeting the students they are ... The donor might be allowed to name the position. Endowed professorships aid the university by providing a faculty member who ... The case of Leona Helmsley is often used to illustrate the downsides of the legal concept of donor intent as applied to ...
According to the Academy, most of these prizes are endowed in perpetuity, though some are funded through other arrangements ... with the school or through private donors. For a school to become part of the program, a $2,500 endowment contribution is ...
Endowments last in perpetuity due to the corpus never being able to be spent. The first community foundation was set up in ... In the USA the donor receives a charitable tax deduction in the year that gifts are made into their funds, but not all ... The assets of community foundations are pooled and invested, with donors typically having a choice of investment products. The ... district or province Are supported by a broad range of private as well as public donors and seek philanthropic contributions ...
... endowing two teaching fellowships in perpetuity and becoming the youngest major donor in the College's history. In April 2019, ...
... by agreement with the donor, to maintain intact in perpetuity or until a specific future date/event or has been used for the ... or a restriction imposed by the donor or provider. These donor/provider restrictions are usually communicated in writing and ... Fund accounting is an accounting system for recording resources whose use has been limited by the donor, grant authority, ... Agency or Custodian funds are held to account for resources before they are disbursed according to the donor's instructions. ...
It is divided into the Wolfson, Nuffield and Spooner Wings, named after donors to the College during its first few decades. ... and her husband Steve Edwards to secure the future of the college as a college at the University of Cambridge in perpetuity. In ... Dame Rosemary Murray and the donors. New Hall was founded in 1954, housing sixteen students in Silver Street where Darwin ...
... Limited was also one of the founding donors of the Lee Kuan Yew School of Public Policy as well as the ... Today, it still supports a chair in business administration and continues in perpetuity. ...
It is a religious endowment by which land and other income-producing property is given in perpetuity for the maintenance of a ... A mutavalli administers a vaqf in accordance with the stipulations in the donor's bequest. In many vaqfs, the position of ...
... to steward donors' wishes in perpetuity, and to build a permanent "nest egg" for the broad community needs of Charlotte and ... If we did, where would it stop?" The bulk of the foundation's donations are made at the direction of donors who may choose to ... The Foundation for the Carolinas is a donor-advised charity with a non-exclusive focus on North Carolina and South Carolina. ... In 2019, FFTC-held funds distributed more than 20,000 grants for a total of $336 million, with donors contributing $298 million ...
... making it the largest donation at the University of Hawaii from a private donor. The Shidler College of Business is accredited ... will generate income in perpetuity to meet the College's long-term financial needs. Shidler offers a Bachelor of Business ... making it the largest donation to the University of Hawaii from a private donor. Mr. Shidler's unique gift of ownership ...
If the property is not used for a market, the donor specifically reserved the right to reclaim the land. The first market sheds ... the City had to use the property to create Market Street and market buildings for that purpose in perpetuity, (2) the City had ... two years to build the market buildings, and (3) the remaining land of the donors that then would front on Market Street could ...
... large areas of stained glass were often accompanied by a bequest or condition that masses for the donor be said in perpetuity, ... although donor portraits had the advantage that the donor could see them displayed in his own lifetime. Furthermore, donor ... Donor portrait usually refers to the portrait or portraits of donors alone, as a section of a larger work, whereas votive ... The purpose of donor portraits was to memorialize the donor and his family, and especially to solicit prayers for them after ...
Rosenwald cautioned donors against perpetuity: "I am opposed to gifts in perpetuity for any purpose." Some donors have ... Many arguments against donor intent are made against honoring it in perpetuity. Such arguments date back at least to the 18th ... Donor intent is considered virtually impossible to be maintained in perpetuity because of changing situations, erosion of ... Donor intent is most often expressed in gift restrictions, terms, or agreements between a donor and donee, but it may also be ...
Donors often provide monetary support, but it is common for conservation-minded landowners to donate an easement on their land ... trusts will sometimes retain ownership of the land in perpetuity, or sell the land to a third party. This third party is often ...
While a foundation can persist for generations or in perpetuity, some sponsoring organizations impose a "sunset" on donor- ... Whitney Ball, co-founder and executive director of the donor-advised fund Donors Trust, described donor-advised funds: A donor- ... A list of prohibited payments to donors and advisers to donor-advised fund. New rules about what grants can be made from donor- ... Donor-advised funds provide a flexible way for donors to pass money through to charities-an alternative to direct giving or ...
Donors include a Who's Who of local philanthropists. Individuals can join the trust for a $50 annual fee, which also grants ... The trust obtains the property rights and can choose to retain the land in perpetuity or coordinate with another organization ... the property owners agree to give up the right to develop the land and to conserve resources in perpetuity. The landowner ... important waters and lands along California's Central Coast and focus on purchasing property for conservation in perpetuity. It ...
Several of the university's large donors were reportedly particularly hard hit due to investment with Bernard Madoff. On July ... "Brandeis's promises that the Rose would be maintained in perpetuity". Ironically, a major new book was to be published in 2009 ... numerous art-world figures and some donors to the museum. The Massachusetts attorney general's office has approval powers over ... Martha Coakley said she planned to conduct a detailed review of the decision relative to wills and agreements made with donors ...
In some legal systems, a settlor is also referred to as a trustor, or occasionally, a grantor or donor. Where the trust is a ... certainty of objects - the beneficiaries must be clearly ascertainable within the perpetuity period. Where a settlement of ... a donor usually refers to someone who grants a power other than a trust. For example, in the United Kingdom, evidence in ...
... to remain in perpetuity as a fund for the establishment of a Professorship of Oratory and Belles Letters." In recognition of ... shall entitle the donor to name the College." The following year, the appeal was answered by College treasurer Nicholas Brown, ...
... after the donor's death, under the care of an administrator (mutawalli) and supervisor (nāzir) selected on the basis of the ... of both to be set aside in perpetuity for the Moroccans in Jerusalem. The Qanṭarat Umam al-Banāt endowment consisted of a hall ...
Enduring power of attorney, which takes effect once the donor is incapacitated The death of the donor ends both. The relevant ... This can be done either for a pre-defined period of time, or in perpetuity ("enduring"). The power of attorney can be granted ... These can be general (i.e. to do anything which can legally be done by the donor in relation to their money or assets), or can ... A solicitor is not required to create a Power of Attorney - it is created simply by being signed by the donor, in the presence ...
Main donors include: Australia, Canada, Germany, Ireland, Norway, Sweden, Switzerland, United Kingdom, United States, the Bill ... By 2011, the Crop Trust had established in-perpetuity support (i.e. grants funded through the Crop Trust's endowment) for ... The Crop Trust Trust also has a Donors' Council, chaired by Jaap Satter (Netherlands). As of May 2016 the organization had ... in perpetuity, through existing institutions. Crop diversity is the biological foundation of agriculture, and is the raw ...
The Acadia Youth Conservation Corps was established by FOA and endowed by an anonymous donor in 1999 to employ 16 high school ... to maintain the park's carriage road system in perpetuity, which leveraged federal funds to fully restore the road system. ...
The SDMF UK Charity is able to accept and channel donations from UK based donors to the benefit of St David's Marist, Inanda.[ ... which will provide financial resources to the School in perpetuity. The Endowment capital is invested to achieve long term ...
According to the January 2008 Penn State press release, The fellowship, named for the donor and his late wife, Beatrice "Bea" ... will match the endowment's annual spendable income in perpetuity, thus increasing the amount available to the recipient in the ...
... particularly that of perpetuity, which a natural person could not have had. Examples are a religious officiant in that capacity ...
The donor of the games sat on a high platform in the stands alongside images of the gods, visible to all. Large sums were bet ... one for ten years and another for perpetuity. He was murdered in 44 BC, on the Ides of March by the Liberatores.[52] ...
... "in perpetuity" (la-zemitut). And Resh Lakish interpreted the words of Leviticus 14:2, "This shall be the law of the person with ... to refer to the donor of a meal-offering, instead of the usual "man" (אָדָם‎, adam, in Leviticus 1:2, or אִישׁ‎, ish, in ...
From 2001-2006, a generous gift from a donor allowed LGBTS to establish and oversee the Larry Kramer Initiative, which hosted a ... stated that gay and lesbian studies was too narrow a specialty for a program in perpetuity. Kramer's rejected proposal read: " ...
The name was changed to Pillsbury Academy in 1886 in honor of one of a major donor, George A. Pillsbury former mayor of ... Pillsbury's transcripts are now held by Maranatha Baptist University in perpetuity. In April 2014 the campus was purchased and ...
The initial contract was for two seasons, but the race was expected to return in perpetuity. On August 16-17 the same year, ... The 39-lap Clauson event, named for an organ donor charity in Clauson's memory, features heat races and last-chance races ...
... to free tuition in perpetuity and were sold until 1867. The university also sold less-expensive limited term "transferable" ... at the north end of campus that would be named Sheppard Field in honor of the University's business manager and lumber donor. ...
"Col.Harmon Dies; Aviation Pioneer; Donor of Aeronautic Trophy a Leader in Modern Technique --Suggested World Force Turned to ... Harmon left $55,000 of his estate to continue funding the award in "perpetuity," but Harmon's relatives challenged the bequest ...
Benet". Often the donor laid the charter of feoffment or some other symbol, such as a knife or other symbol of possession, upon ... Several cases are recorded where the King specifically forbade the tenant from alienating a church or land held in perpetuity ... Frequently, land would be donated to a religious body, which would simultaneously re-let it to the donor, in order to evade ... Coke held that it could not be voided by the donor's overlord, an opinion reiterated by Bracton. The Statute made provision in ...
Shaykhu t-Taifa considered the ulamā' the best agents of the donor to distribute religious taxes since they knew to whom it ... Contrary to Usulis, Akhbaris believe in the perpetuity of Sharia from only the infalibles, so the right to interpret the Quran ... develop from the deputies of the donor for the distribution of religious taxes in his early writings to being the deputies of ... as the trustees of the Imām for distribution and the donor who distributed these himself was considered to obtain no reward. ...
Article 28 of the Mandate required that those rights be safeguarded in perpetuity, under international guarantee. The General ... a Palestinian state would remain donor dependent. In April 2011, the UN's co-ordinator for the Middle East peace process issued ...
In 2013, Lee authored Act 112 which created a new law requiring superPACs to disclose their top donors in all elections ... "a first step that must be taken to make sure we have this incredible valuable resource protected in perpetuity." In a ... "Pay to Play Prohibition Amendment" (PDF). "Super PACs must list top donors under bill". Honolulu Star-Advertiser. 2013-04-14. ...
... the system goes on in perpetuity." Two of Aguirre's supervisors left the SEC for lucrative positions at private law firms. Paul ... Wall Street Is Bush's Biggest Donor" The New York Times (October 23, 2003). Retrieved March 4, 2011 Senate report, pp. 28-29 " ...
"DONORS AND SUPPORTERS". Orangutan Foundation UK. n.d. Retrieved 3 March 2021. "Short Stories: Terry Pratchett's Jungle Quest". ... In 2015, Pratchett's estate announced an in-perpetuity endowment to the University of South Australia. The Sir Terry Pratchett ...
Arents eventually inherited her uncle's fortune and used the money to create and support in perpetuity a number of social ... Parents, teachers, staff, volunteers, and donors support the school's daily operations. St. Andrew's School adheres to the ...
If the gift is of land and made during the donor's lifetime, it must comply with Section 53(1)(b) of the Law of Property Act ... Charitable trusts are also exempt from many formalities when being created, including the rule against perpetuities. The ... This is only possible when the trust instrument indicates that the donor intended for the fund to be divided, and cannot work ... to make charities more accountable to the donors, beneficiaries and the public. Along with these objectives, it has six ...
Stryker is a donor of the New York Community Trust, which announced in 2020 that it would donate $75 million to the city's ... easements were placed on the property to ensure that the land remains protected and accessible to the public in perpetuity. In ... "Donor gives $325K to fight Minn. gay marriage ban". The Sacramento Bee. August 7, 2012.[permanent dead link] "Mystery Point ... Stryker was named one of the nation's Top 50 donors by the Chronicle of Philanthropy every year from 2006 to 2012 and again in ...
From 2001-2006, a generous gift from a donor allowed LGBTS to establish and oversee the Larry Kramer Initiative, which hosted a ... then-Yale provost Alison Richard said that gay and lesbian studies was too narrow a specialty for a program in perpetuity, ...
But if seisin did not follow upon the gift it cannot be maintained after the donor's death against the will of the heir, for it ... 12 28 American Jurisprudence 2nd Estates 61 American Jurisprudence 2nd Perpetuities and Restraints on Alienation Henderson, E. ... In general, it was held that a donor should pay the other parties who had an interest to give them relief. However, the results ... It certainly could not be voided by the donor's lord. This opinion was reiterated by Bracton. The use of land by tenants (serfs ...
... to ensure Masses would be said for their souls in perpetuity. Families with an ordained priest as a member often designated him ... founded in 1774 with funds of a single ecclesiastical donor, Choirmaster of the Cathedral, Fernando Ortiz Cortés, who became ...
Update on Donor Privacy Case in California; Corporate Foundations, Annual Distributions, and Self-Dealing; Nonprofits Coalesce ... Behind Solutions to Student Loan Debt Crisis; Foundation Leaders Continue to Speak on the Value of Perpetuity; and more! ...
While a foundation can persist for generations or in perpetuity, some sponsoring organizations impose a "sunset" on donor- ... Whitney Ball, co-founder and executive director of the donor-advised fund Donors Trust, described donor-advised funds: A donor- ... A list of prohibited payments to donors and advisers to donor-advised fund. New rules about what grants can be made from donor- ... Donor-advised funds provide a flexible way for donors to pass money through to charities-an alternative to direct giving or ...
Rosenwald cautioned donors against perpetuity: "I am opposed to gifts in perpetuity for any purpose." Some donors have ... Many arguments against donor intent are made against honoring it in perpetuity. Such arguments date back at least to the 18th ... Donor intent is considered virtually impossible to be maintained in perpetuity because of changing situations, erosion of ... Donor intent is most often expressed in gift restrictions, terms, or agreements between a donor and donee, but it may also be ...
New investment is vital to ensure ecosystem recovery and perpetuity.". Key to the future viability of conservation in the ... Pioneering investment to protect Pacific ecosystems presents new opportunity for donors By BirdLife Pacific ... for donor investment." About the Critical Ecosystem Partnership Fund - The Critical Ecosystem Partnership Fund is a joint ... international and local organizations and donor agencies, to ensure this good work continues for the people of the Pacific." ...
As a not-for-profit project, were dependant on volunteers and donors to:. *Adopt a seed into the library, protecting it in ... perpetuity. *Grow out seed and return freshly-saved seed to us. *Donate varieties from your seed collection ...
... major donor that the donors name would be attached to a gallery at the Metropolitan Museum of Art "in perpetuity." The donor ... shrewdly asked, "How long does perpetuity last?" Montebello candidly replied "Fifty years." In answer to the Editors ...
Donor Advised Funds. Gifts made by donor-advised funds are recorded on the on the record of the Donor Advised Fund. ... Endowments are intended to be held in perpetuity; therefore spending typically comes from accumulated earnings from investment ... As evidence of donor intent and documentation of restrictions for gifts to be made in the future, donors will be asked to fill ... If the donor wishes to claim a charitable donation and the value of the item exceeds $500, the donor must complete IRS form ...
To assure that philanthropy merits the respect and trust of the general public and that donors and prospective donors can have ... Endowments are gifts held in perpetuity and invested in a manner that protects the principal from inflation. The investment ... What are my rights as a donor?. The University Development Office feels strongly that philanthropy is based on voluntary action ... To read more about these rights, please go to the following link: Donor Bill of Rights. ...
Naming the Director position would link a donors name with excellence in worldwide dental leadership in perpetuity. ...
This fund includes all gifts from donors who designate their donations to the endowment. The principal of the fund is invested ... The principal remains untouched, so the endowment can last into perpetuity. Income from the investment of these funds is used ... China and the United States as Aid Donors: Past and Future Trajectories. Patrick Kilby ...
Among Our Many Donor Investments. *A major multi-year investment to fund the planning and launch of the Center of Excellence in ... A $1 million endowment to support basic neuroscience research in perpetuity. *Many targeted gifts from individuals and ... Among Our Many Donor Investments. *An endowed fellowship to train the finest post-doctoral fellows and faculty members who are ... Among Our Many Donor Investments. *An $8.6 million unrestricted gift-half for endowment and half for current use-to fund ...
Donor philanthropy comes in many forms. Every year, donors give annual gifts that provide expendable funds that go directly to ... They may establish an endowment that provides funds in perpetuity, supporting many students year after year. They may decide to ... While the Hathaway was created by the state, many scholarships are created by donors-donors love to support students directly ... There are many other ways donors impact students. Donors support professors and their research, and often its corporations and ...
the donors intent must be respected even when the donor has died. Societies grow and change, but the mission defined by the ... creator of the foundation remains the mission in perpetuity." Do we really think the need for libraries is going to vanish? The ... Perfect separation between the donors and the endowment? Of course not, since the donors would play a role in governance. But ... Major donors would not contribute if they felt that the endowment would essentially just substitute its funds for tax money at ...
... and it exists in perpetuity. We are grateful to donors for establishing the following endowed chairs, which were celebrated ... Donors invest in the future. Generous donors have established 46 endowed chairs at Childrens Hospital Colorado since 1997 as a ... With donor support, Childrens Hospital Colorado led the effort to develop the first new childhood leukemia drug in more than a ... By partnering with donors who care as deeply as we do about eradicating childhood cancers, well continue to pioneer new cancer ...
Interested donors should meet with The Arboretum Director or designate in selecting a tree for their dedication. A dedicated ... tree will be cared for in perpetuity and would be replaced if it dies so the dedication is maintained. ...
Rather than the entire fund being utilized at once, your gift is invested in perpetuity. The Physicians Committee has ... protecting the future income stream against inflation and providing the donor(s) a lasting legacy, guaranteeing that the ... either individually or with multiple donors participating. ...
... gains or losses on split-interest agreements for which distributions are not donor-imposed to be invested in perpetuity. ... Temporarily restricted funds that have met the restrictions of the donor and are available to be used to support University ... Gifts received by the University that have donor-imposed restrictions expiring with the passage of time, the occurrence of an ... Gifts pledged to the University that have donor-imposed restrictions expiring with the passage of time, the occurrence of an ...
Drawing on a relatively unique dataset of foundation donors, and combining it with a large archive of tax returns filed by ... Other legal rules further encourage grant-making institutions to strive to exist "in perpetuity.". This Essay offers new ... Since the timing of the donors death is relatively random, these outcomes offer convincing causal evidence that the ability of ... as soon as the organizations last living donor dies. Payout rates, or the share of assets spent each year, move sharply in the ...
The Van Weelden family created a donor-advised fund to give back in perpetuity ... Donor Stories, Granting in Action A Lasting Legacy. ...
Under a conservation agreement, the landowner continues to own the land, but the property is protected in perpetuity from ... Donors honored for conservation easements * font size decrease font size increase font size ...
Donor countries cannot maintain funding of several billion dollars a year in perpetuity, and a resurgence of malaria could ... We also advocate for sustained and increased funding of malaria-related efforts by donor governments and endemic countries. ...
Gifts are invested in perpetuity. A portion of the distribution (interest) of any given endowment fund may be reinvested in the ... fund at the request of the donor or the department to further enhance the funds buying power over time. Presently, four to ...
... earned from generous donations made to the Center by donors who wanted to ensure that important work can continue in perpetuity ... Become a donor (or renew your support!). *Sign up to receive our newsletters, monthly Pasture Calendar, and/or event ...
We are now looking to expand that site to approximately 350 acres and secure it as a great ape sanctuary in perpetuity - by ... This value will be re-assessed once a prospective donor steps forward to make an offer to Maui Land & Pineapple Company on the ... The land acquisition has become an important prerequisite for continuation of the project. A major donor or corporation ... 2011 - 2014: TGF decided to focus on improving its present home in northern California until the right donor (or corporation) ...
In other words, Colorado is and will continue to be a donor state, just as it is in federal highway funding. ... That 1.15 percent is fixed in perpetuity even though our share of the national population will soon approach 2 percent. ...
Just because a prominent person used to be an active trustee or donor may not justify storing her personal details in the ... perpetuity. ... For example, just because an organization acquires donor or ... They depend on IT to convey and store data about trustees, donors, business partners and clients that need to be kept ...
... which provides a permanent bond between the donor and the NCSBS. Through an endowed fund the donor... ... Through an endowed fund the donor transfers assets to the NCSBS, which are carefully managed and preserved in perpetuity to ... Donors may specify what purposes the endowed fund is to serve and how the fund is to be administered. The NCSBS carefully ... We are happy to work with donors to build an endowed fund over the years; additional gifts may be added to an endowed fund at ...
Another of the evangelists (Matthew 6:1-4) warns donors not to "sound a trumpet before thee as the hypocrites do ... that they ... will be affixed in perpetuity. Monogrammed giving is easy to mock. But it satisfies more than a normal human desire to purchase ... It also serves as an enduring example to other potential donors, and so its beneficence may be multiplied in years to come. ... note the many caveats we are obliged to state in the introduction to our SLATE 60 list of Americas biggest donors. How much ...
Donors like the assurance that their gift will be managed wisely, and they find it appealing that an endowment will provide ... support in perpetuity. In one instance, Paul Brandt, a conservation donor made a 1,000-fold increase in his annual membership ... An anonymous donor created an endowment to support the Turtle Flambeau Flowage, which supports a wide variety of activities ... Other donors have made additional contributions to this growing endowed fund.. Through the Natural Resources Foundation, ...
  • In philanthropy, donor intent is the purpose, sometimes publicly expressed, for which a philanthropist intends a charitable gift or bequest. (
  • Finally, respect for donor intent is defended as necessary to preserve pluralism in civil society: "Those who take the idea of donor intent seriously believe that only by protecting the idiosyncratic and at times outlandish ideas of donors will it be possible for philanthropy to innovate and pursue ideas that are either ahead of or behind their time," Frumkin has said. (
  • Last year alone, donor philanthropy resulted in more than $17 million in scholarship support for students. (
  • Yet all this time, there were individual donors and philanthropy executives sitting on large pools of money that could theoretically have been used to help address many of our biggest concerns. (
  • Environmental philanthropy is a growing area of interest nationally, and among The Denver Foundation's community of donors. (
  • But of course it's me so I can't resist giving you just a teensy tiny overview of what they are because, in many ways, my Donor Advised Fund is the cornerstone of my strategic philanthropy. (
  • This value will be re-assessed once a prospective donor steps forward to make an offer to Maui Land & Pineapple Company on the Gorilla Foundation's behalf. (
  • Since the timing of the donor's death is relatively random, these outcomes offer convincing causal evidence that the ability of a donor to monitor her foundation's managers importantly affects whether those managers follow her wishes. (
  • Past grantees such as the Thorne Ecological Institute and Environmental Learning for Kids are helping to train the next generation of caring citizens and budding scientists.Many of the Foundation's donors support a broad range of environmental causes through grants from their donor-advised funds to groups working at the national and international level, such as World Wildlife Fund, Trust for Public Land and the Sierra Club. (
  • However, donors must realize there may be conditions beyond the Foundation's control that threaten donated plantings. (
  • The national endowment could help fund the two digital systems, with other money coming from states, other government entities, educational institutions, and other philanthropic donors. (
  • Akron Community Foundation was established in 1955 to improve the quality of life in the Greater Akron area by building permanent endowments and providing philanthropic leadership that enables donors to make lasting investments in the community. (
  • A prima donor is a woman who is thinking of her philanthropic passions, planning her estate, and thinking about her legacy. (
  • Donor-advised funds provide a flexible way for donors to pass money through to charities-an alternative to direct giving or creating a private foundation. (
  • In addition, most donor-advised funds can solely give to IRS certified 501(c)(3) organizations or their foreign equivalents. (
  • Donor-advised funds do reap a significant cost advantage (foundations carry a 2.5-4% of assets overhead expense to maintain, a 1-2% excise tax on NET investment earnings and a required 5% spending of assets each year) but may also have one more drawback: a limited lifetime, although this varies depending on the sponsor. (
  • While a foundation can persist for generations or in perpetuity, some sponsoring organizations impose a "sunset" on donor-advised funds, after which they collapse individual funds into their general charity pool. (
  • Most foundations that offer donor-advised funds only make grants from these funds to other public charities, and usually perform due diligence to verify the grantee's tax-exempt status. (
  • citation needed] Drexel University environmental sociologist Robert Brulle, who has studied networks of nonprofit funding, described donor-advised funds: In this type of foundation, individuals or other foundations contribute money to the donor directed foundation, and it then makes grants based on the stated preferences of the original contributor. (
  • Whitney Ball, co-founder and executive director of the donor-advised fund Donors Trust, described donor-advised funds: A donor-advised fund begins with a donor contributing cash or assets to a public charity, which in turn creates a separate account for the donor, who may recommend disbursements from the fund to other public charities. (
  • Donor funds support students in their extra-academic experiences, which augment their educations and give them a leg up in their careers. (
  • Some donors have designated legacy gifts so that the Foundation can steward the funds in perpetuity to support pressing environmental causes as they evolve over time. (
  • Donors contributed over $50,000 and AUGS matched the donations up to $50,000 for over $100,000 in funds raised. (
  • The Denver Foundation works with our donors to support a broad range of environmental causes through grants from their funds. (
  • We do not promise funds in perpetuity to organizations nor can we commit to increasing the level of support that we provide in the future because an organization's operating budget is increasing due to a facility expansion. (
  • To celebrate John's passion for leadership and his lasting impact on the chemical engineering profession, the endowment will provide scholarship funds to support, in perpetuity, the leadership development training of two selected young professional members of AIChE annually. (
  • Endowments are permanent funds held by Children's Mercy Hospital that are designed to last in perpetuity. (
  • One of the meeting highlights was the announcement of the Campaign for Sustainability, with a goal of raising $1.5 million in endowed funds to help maintain the non-profit's many programs in perpetuity. (
  • Last year I wrote an extensive overview of Donor Advised Funds in How We Make Meaningful And Tax Efficient Charitable Donations , so I won't belabor the point. (
  • Donor Advised Funds (abbreviated as DAFs) are a tax-advantaged way to make charitable gifts. (
  • This revenue funds projects and activities that protect or restore forests, often supporting local communities with alternative livelihood opportunities that keep trees standing, and it helps fund programs to do so in perpetuity. (
  • These endowment funds are invested permanently, where only the interest from the investment is used to fund the long-term research position in perpetuity. (
  • Endowed funds are carefully managed for growth, and will help the hospital in perpetuity. (
  • In the United States, a donor-advised fund (commonly called a DAF) is a charitable giving vehicle administered by a public charity created to manage charitable donations on behalf of organizations, families, or individuals. (
  • To participate in a donor-advised fund, a donating individual or organization opens an account in the fund and deposits cash, securities, or other financial instruments. (
  • A donor-advised fund is an account at a sponsoring organization, generally a public charity, where an individual can make a charitable gift to enjoy an immediate tax benefit and retain advisory privileges to disburse charitable gifts over time. (
  • The contribution a donor makes to their donor-advised fund is 100% irrevocable and destined for a final 501(c)(3) organization. (
  • Donors enjoy administrative convenience (the sponsoring organization does the paperwork after the initial donation), cost savings (a foundation requires around 2.5% to 4% of its assets each year to run), and tax advantages (versus individual giving) by conducting their grantmaking through the fund. (
  • On average, conversion time for a contribution to a donor-advised fund to a grant from the donor-advised fund, is approximately 24 months. (
  • citation needed] A donor-advised fund has some disadvantages compared to a private foundation, and some advantages. (
  • Both can accept donations of unusual or illiquid assets (e.g., part ownership of a private company, art, real estate, partnerships or limited partnership shares), but a donor-advised fund has higher deductions for these gifts (depending on the gift). (
  • In a donor-advised fund, the donor only advises the sponsoring organization where the money should go. (
  • Because a public charity houses the fund, donors receive the maximum tax deduction available, while avoiding excise taxes and other restrictions imposed on private foundations. (
  • The donor receives the maximum tax deduction at the time they donate to their account, and the organization that administers the fund gains full control over the contribution, granting the donor advisory status. (
  • As such, the administrating fund is not legally bound to the donor, but makes grants to other public charities on the donor's recommendation. (
  • Rather than the entire fund being utilized at once, your gift is invested in perpetuity. (
  • This table shows the monthly gift amounts needed to establish a $25,000 endowed fund - either individually or with multiple donors participating. (
  • Among others, I support maintaining or increasing legal requirements for mandatory distributions by private foundations, and closing legal loopholes offered by a relatively new charitable phenomenon, the donor advised fund. (
  • An individual or family can create an endowed fund, which provides a permanent bond between the donor and the NCSBS. (
  • Through an endowed fund the donor transfers assets to the NCSBS, which are carefully managed and preserved in perpetuity to provide annual income. (
  • Donors may specify what purposes the endowed fund is to serve and how the fund is to be administered. (
  • A portion of the distribution (interest) of any given endowment fund may be reinvested in the fund at the request of the donor or the department to further enhance the fund's buying power over time. (
  • 100% of WLF Angel contributions are placed in the endowed fund so they can provide future grants in perpetuity. (
  • This message was the core of an electronic appeal shared with 600+ friends and donors of CEU as part of the CEU Development Office's annual end-of-year fund drive. (
  • Some of our donors support groups working at the national and international level, such as World Wildlife Fund, Trust for Public Land and the Sierra Club. (
  • The intent is to build the fund to the $10,000 level to endow the fund in perpetuity. (
  • When donors establish an endowed fund, they have the option to name the fund-for themselves, creating a legacy typically at their alma mater-or for someone in their lives, such as a parent or faculty member. (
  • Thus, the fund continues to generate interest income for the area designated by the donor-often this is in the form of financial aid for students through scholarships and/or fellowships-in perpetuity. (
  • The original donor to this fund, Dr. Alfrieda M. Frost, was a lifelong educator who held two degrees from the Department of Educational Administration. (
  • Many billionaires donate through private foundations and a Donor Advised Fund is a lot like having your very own private foundation, but without all the administrative and tax burdens, and with many of the benefits! (
  • A donor-advised fund is a type of giving program that allows you to combine the most favorable tax benefits with the flexibility to easily support your favorite charities. (
  • A donor-advised fund is a flexible, strategic giving vehicle available to any donor who is able to meet the minimum initial contribution requirement (sometimes as little as $5,000). (
  • We hope that the value of this work is recognised and supported by all governments, international and local organizations and donor agencies, to ensure this good work continues for the people of the Pacific. (
  • Drawing on a relatively unique dataset of foundation donors, and combining it with a large archive of tax returns filed by private foundations, I search for evidence that managers of long-lasting organizations depart significantly from the preferences of the organization's supporters. (
  • As a result of the ongoing effects of the drought, recent wildfires and persistent pockets of poverty, California's needs in the coming year will be great, and year-end giving is an opportunity for donors to make a difference through their support. (
  • The confluence of technology and donor support has created tremendous forward momentum toward understanding and treating these common and life-altering conditions. (
  • While the Hathaway was created by the state, many scholarships are created by donors-donors love to support students directly through scholarships. (
  • Over the years, more than 900 UW endowments that provide scholarships and other student support have been created by donors, and countless students have benefited from this generosity. (
  • With donor support, Children's Hospital Colorado led the effort to develop the first new childhood leukemia drug in more than a decade. (
  • We deliver a comprehensive suite of services and support to CBC students, alumni, donors and friends. (
  • The Physicians Committee has investment and spending policies in place designed to preserve the purchasing power of the principal over the long term, protecting the future income stream against inflation and providing the donor(s) a lasting legacy, guaranteeing that the Physicians Committee will still have the support it needs far into the future. (
  • In the ideal case, a private foundation can support a family's charitable vision in perpetuity. (
  • Established in 2012, the endowment provides partial annual funding support to the local NGO, TKCP-PNG, for the management and protection of the YUS Conservation Area in perpetuity. (
  • To sustain all of the great new educational programs and ambitious, large-scale works that will be made possible once the facility is completed, it will be counting on increased support from its most loyal donors. (
  • Thanks to all the support, the Save 1000 Acres campaign raised more than $11 million over the last four years to protect these 975 acres in perpetuity. (
  • Donors pledging support at this level for three or more years will be included in our Leadership Circle and receive special acknowledgment in our publications. (
  • Written into Nancy Ives' will, her planned gift will establish the Nancy Wilson Ives Biological Sciences, Health Sciences and Physical Sciences scholarships in perpetuity, enabling more students to obtain degrees in those areas of study. (
  • Defenders of donor intent argue that on a basic ethical level, trustees and gift recipients must do what they have agreed with the original donor to do, explicitly or implicitly: "When donor intent is violated, and particularly when it is egregiously violated, it undermines the bedrock trust on which all charitable giving rests. (
  • I find that a firm's overhead, or the ratio of administrative expenses to grants made, jumps by about 12% as soon as the organization's last living donor dies. (
  • Once this goal is met, The Foundation will be able to guarantee funding of two research grants in perpetuity. (
  • I shall show in the course of this book, 2 that, independently of the grants which the princes made for a certain time, there were others in perpetuity. (
  • Endowments are gifts held in perpetuity and invested in a manner that protects the principal from inflation. (
  • Link your name with New Hampshire Humanities in perpetuity by making a gift to one of our endowments by contacting Lynn Douillette . (
  • Naming the Director position would link a donor's name with excellence in worldwide dental leadership in perpetuity. (
  • Donor intent is protected in American law regarding charitable trusts, and trustees' primary fiduciary obligation is to carry out a donor's wishes. (
  • In some instances, however, donor intent has been lost only a short time after a donor's death. (
  • The Alumni Association Scholarship is an example of a donor-supported scholarship. (
  • His effusive passion and dedication to the theatre arts will live on in perpetuity through the students this scholarship aids. (
  • Prima Donors are contributors who have made a commitment to the WLF of $10,000 or more. (
  • The team says the breakthrough will allow farmers to preserve sperm from prized animals in perpetuity. (
  • American Endowment Foundation for example allows successor advisors in perpetuity. (
  • Many are finding the value in utilizing the assistance of surrogate mothers, egg donors and sperm donors. (
  • Existing methods involve using chemotherapy drugs or irradiation to remove sperm stem cells from the recipients before transplanting donor cells. (
  • Donor intent is considered virtually impossible to be maintained in perpetuity because of changing situations, erosion of capital, and the distance of successor trustees from a donor. (
  • Future donors might not be inclined to leave money to charitable causes if they see that trustees, grant recipients, or policymakers do not respect the stated intent. (
  • They depend on IT to convey and store data about trustees, donors, business partners and clients that need to be kept confidential. (
  • Lastly, research continues to look at the storage life of cord blood units, and paying a yearly fee for a child until age 18, 21 or into perpetuity may not even guarantee the stem cells' viability. (
  • Donor intent is thus also defended as necessary to ensure future charitable giving. (
  • The vision and dedication of the greater Akron community's leaders have helped Akron Community Foundation plan for tomorrow by building a permanent, growing charitable endowment that will provide income in perpetuity. (
  • Thank you to the generosity of our donors, the PFD Research Foundation was able to meet its goal of raising $100,000 in DC. (
  • Baker is an excellent example of how donors' gifts impact UW students and how students give back to the university they love. (
  • Gifts are invested in perpetuity. (
  • The following are just a few examples of the life changing impact our donors' gifts have on our students, our campuses and both our local and global communities. (
  • Then, you're able to make gifts out of your DAF in perpetuity. (
  • Mitt Romney told his top donors Wednesday that his loss to President Obama was a disappointing result that neither he nor his top aides had expected, but said he believed his team ran a "superb" campaign with "no drama," and attributed his rival's victory to "the gifts" the administration had given to blacks, Hispanics and young voters during Obama's first term. (
  • Donors often choose to make a contribution in the form of gifts that provide them and/or their beneficiary income for life. (
  • 5. Obtain Informed Consent - Obtain informed consent agreements from the surrogate/donor (and if married, their spouses), the fertility program and/or clinic you have chosen. (
  • Because contributions to a donor directed foundation are not required to be made public, their existence provides a way for individuals or corporations to make anonymous contributions. (
  • It can't be to make the Yale School of Music the best in the nation, as Ann suggested: if I may make a legal comparison, that would be like a donor giving a huge sum of money to a law school like Southern Methodist University. (
  • We want to understand what Wikimedia and Wikipedia mean to people-from our community to our readers to our donors to our partners-and make sure that we can clearly communicate the values that we stand for and why people love Wikipedia. (
  • Donors make the difference. (
  • Further, donors avoid the cost of establishing and administering a private foundation, including staffing and legal fees. (
  • 1] Carl Schramm, former president of the Ewing Marion Kauffman Foundation, has said on donor intent, "If we dont recognize it, we discourage wealthy people from creating foundations in the future. (
  • Potential donors may contact the Foundation for suggestions of trees appropriate for the Garden (see also Attachment A). (
  • Plaques identifying the species and honoring the donor or loved one will be installed according to Foundation standards on or near the memorial tree. (
  • Romney argued that Obama's healthcare plan's promise of coverage "in perpetuity" was "highly motivational" to those voters making $25,000 to $35,000 who might not have been covered, as well as to African American and Hispanic voters. (
  • You (the donor) are able to take a tax deduction for the full dollar amount you put into your DAF in the calendar year you decide to put money in your DAF. (
  • Following a successful pilot phase, a generous donor recently made it possible for the program to continue through 2021. (
  • 2011 - 2014: TGF decided to focus on improving its present home in northern California until the right donor (or corporation) is found to purchase the land for TGF in perpetuity. (
  • A big idea requires partners with a shared vision, so the Conservancy teamed up with the Palomar Audubon Society, the Friends of Daley Ranch, San Diego County Parks and Recreation, the U.S. Navy, the State of California, Marine Corps Camp Pendleton and hundreds of supporters, including the San Pasqual Band of Mission Indians, and donors to the Save 1000 Acres campaign. (
  • These arrangements can provide donors significant tax benefits. (
  • The American people can't afford to wait in perpetuity for us to grow faster, create more jobs, strengthen our middle class, clean our environment, fix our immigration system," Obama said. (
  • The Blinken Open Society Archives is named for the donors to the valuable collections related to the Cold War and human rights. (
  • So the idea was: How do you enable those people who love Africa and would love to see Africa's spectacular wildlife diversity survive in perpetuity - how do you help those people help the actual conservationists working on the ground? (
  • Fidelity to donor intent is sometimes distinguished from grant compliance, and "donor intent" refers to the actions of a grantmaking entity and grant compliance refers to the actions of a grant recipient, but the term donor intent is commonly used to refer to both the guiding principles of a grantmaking entity and the purposes of a specific gift. (
  • For the more than 100 attendees, including donors, officials and volunteers this event was part 30th anniversary celebration, part tribute and part welcome to the agencies' newest members to their Board of Directors. (
  • Survey data of Americans indicates that donor intent and grant compliance are valued by the public. (
  • Other legal rules further encourage grant-making institutions to strive to exist "in perpetuity. (
  • Donor intent is most often expressed in gift restrictions, terms, or agreements between a donor and donee, but it may also be expressed separately in the words, actions, beliefs, and giving practices of a philanthropist. (
  • He declined to discuss the donors, but said the pledge was a single gift. (
  • Jake: That's why the donor has to limit the gift as this one did. (
  • In making this gift, the donors wish to acknowledge Dr. Kemp's role as a professor and friend of the University in "such a manner as to illustrate the importance that he places on education by providing financial aid to those worthy of assistance in the pursuit of studies in Chemistry. (
  • We are pacing really well, and typically we go above that fundraising target because we have other sources of funding that we need to be investing in, including our endowment that we launched in January 2016, which has a goal of ensuring that Wikipedia remains in perpetuity. (
  • Thoughts of donor conception practices from a donor offspring whose views changed dramatically once he had children of his own. (
  • 6. Execute Legal Contracts - Work with an attorney knowledgeable in reproductive law to draft, negotiate and finalize legal agreements as needed with infertility specialists, agencies and/or third-party donors or surrogates. (
  • Both Open and Leadership Circle donors receive advance notice of special programming and invitations to be our guest at select programs. (
  • Matthew's story is a moving one for future business students and potential donors. (
  • In words of thanks for his donors, Romney said he never expected the campaign to raise more than $500 million. (
  • Circle Donors lead by example, inspiring others to invest as generously as possible. (
  • Our donors invest in what matters most - our health, the health of our loved ones and the health of our community. (
  • An anonymous donor recently offered the museum $1 million if it would take time to more carefully consider its options for the future apart from selling its art collection, the single part of the Berkshire Museum that makes it special. (
  • Romney said he and his team were discussing how to keep the campaign's donor group connected - perhaps with annual meetings or a monthly newsletter - "so we can stay informed and have influence on the direction of the party, and perhaps the selection of a future nominee. (
  • Maintaining good contact with donors can assist with any future questions about the item. (
  • Prima Donors get together for round tables, dine-arounds and educational opportunities to learn more about the community and emerging issues. (
  • As a community, we now live so much for perpetuity that we fail to deal with the present. (
  • Funded by a community of donors, endowed research chairs at the QEII are world-renowned experts in their field who are appointed for a five-year term. (
  • Many arguments against donor intent are made against honoring it in perpetuity. (
  • 689.13 Rule against perpetuities not applicable to dispositions of property for private cemeteries, etc. (
  • It also serves as an enduring example to other potential donors, and so its beneficence may be multiplied in years to come. (
  • For nearly 200 years, Massachusetts General Hospital's accomplishments in life-saving patient care, cutting-edge medical research and superb caregiver education have been nurtured by the legacy of its committed donors. (
  • This was due in large part to a match challenge from an anonymous donor. (
  • Rios and others have attempted to justify the Ayers visit on the basis that it was privately funded by "an anonymous donor" who has endowed the center with a million dollars. (
  • Donor countries cannot maintain funding of several billion dollars a year in perpetuity, and a resurgence of malaria could threaten hard-won progress. (
  • Listen to your donors, do research, ask what messages resonate and conduct A/B testing on messaging used in e-mail and site banners. (
  • We listen to our donors and our readers, and we do research. (
  • Interested donors should meet with The Arboretum Director or designate in selecting a tree for their dedication. (
  • A dedicated tree will be cared for in perpetuity and would be replaced if it dies so the dedication is maintained. (
  • For memorial donations totaling at least $150.00 (or More) a personalized message "wall tile" is displayed in the museum in tribute to the deceased in perpetuity. (
  • All regular membership benefits on a continuous basis, plus a signatured "Wall Tile" mounted and displayed in our museum in perpetuity. (
  • For memorial donations totaling at least $150 a personalized message "wall tile" is displayed in the museum in tribute to the deceased or loved one in perpetuity. (
  • Donors are responsible for paying the purchase cost of the tree from the chosen nursery plus the nursery delivery fee to the site. (
  • If for any reason the adopted tree must be removed from the Garden, the donor will be given the opportunity, at no additional cost, to adopt another memorial tree. (
  • The one-time cost of adopting a tree to honor a special friend or loved one in perpetuity is $500. (
  • When using a public donor cord blood bank, the bank pays for the collection and storing of the baby's cord blood, and there is no initial or yearly bill for storing the blood. (
  • The donor will be informed of the scheduled planting time and location in order to offer the opportunity for the donor to be present at the planting. (