Peripheral nervous system diseases. Medical search

Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.

Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.

The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.

Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.

Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.

An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.

Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.

The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.

The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.

A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)

A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)

Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.

Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.

A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, usually causing an inapparent intestinal infection in mice. A small number of mice may show signs of flaccid paralysis.

The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.

A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.

The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.

The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)

The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.

Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.

A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.

Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.

Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)

Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.

Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.

A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during mitosis.

Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)

The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.

Renewal or physiological repair of damaged nerve tissue.

Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).

The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.

Characteristic properties and processes of the NERVOUS SYSTEM as a whole or with reference to the peripheral or the CENTRAL NERVOUS SYSTEM.

A protein that accounts for more than half of the peripheral nervous system myelin protein. The extracellular domain of this protein is believed to engage in adhesive interactions and thus hold the myelin membrane compact. It can behave as a homophilic adhesion molecule through interactions with its extracellular domains. (From J Cell Biol 1994;126(4):1089-97)

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.

Injuries to the PERIPHERAL NERVES.

Elements of limited time intervals, contributing to particular results or situations.

The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.

A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)

MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.

Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.

An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)

The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.

Regularly spaced gaps in the myelin sheaths of peripheral axons. Ranvier's nodes allow saltatory conduction, that is, jumping of impulses from node to node, which is faster and more energetically favorable than continuous conduction.

Postmortem examination of the body.

Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.

A subclass of closely-related SOX transcription factors. Members of this subfamily have been implicated in regulating the differentiation of OLIGODENDROCYTES during neural crest formation and in CHONDROGENESIS.

The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.

Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures.

An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.

Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.

Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.

Specialized organs adapted for the reception of stimuli by the NERVOUS SYSTEM.

A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.

Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.

Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.

Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.

Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.

Twelve pairs of nerves that carry general afferent, visceral afferent, special afferent, somatic efferent, and autonomic efferent fibers.

Specialized afferent neurons capable of transducing sensory stimuli into NERVE IMPULSES to be transmitted to the CENTRAL NERVOUS SYSTEM. Sometimes sensory receptors for external stimuli are called exteroceptors; for internal stimuli are called interoceptors and proprioceptors.

A branch of the tibial nerve which supplies sensory innervation to parts of the lower leg and foot.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

Neurons which activate MUSCLE CELLS.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.

The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.

Drugs that act principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system. (From Smith and Reynard, Textbook of Pharmacology, 1991, p75)

Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

Clusters of multipolar neurons surrounded by a capsule of loosely organized CONNECTIVE TISSUE located outside the CENTRAL NERVOUS SYSTEM.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

An early growth response transcription factor that controls the formation of the MYELIN SHEATH around peripheral AXONS by SCHWANN CELLS. Mutations in EGR2 transcription factor have been associated with HEREDITARY MOTOR AND SENSORY NEUROPATHIES such as CHARCOT-MARIE-TOOTH DISEASE.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.

An infant during the first month after birth.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

Mice which carry mutant genes for neurologic defects or abnormalities.

In tissue culture, hairlike projections of neurons stimulated by growth factors and other molecules. These projections may go on to form a branched tree of dendrites or a single axon or they may be reabsorbed at a later stage of development. "Neurite" may refer to any filamentous or pointed outgrowth of an embryonal or tissue-culture neural cell.

Clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons. Sensory ganglia may also have intrinsic interneurons and non-neuronal supporting cells.

A group of disorders characterized by an autosomal dominant pattern of inheritance with high rates of spontaneous mutation and multiple neurofibromas or neurilemmomas. NEUROFIBROMATOSIS 1 (generalized neurofibromatosis) accounts for approximately 95% of cases, although multiple additional subtypes (e.g., NEUROFIBROMATOSIS 2, neurofibromatosis 3, etc.) have been described. (From Neurochirurgie 1998 Nov;44(4):267-72)

Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.

The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.

Catalyzes the final step in the galactocerebroside biosynthesis pathway.

Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.

Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.

A species of fruit fly much used in genetics because of the large size of its chromosomes.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.

Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)

An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.

Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.

A general term indicating inflammation of a peripheral or cranial nerve. Clinical manifestation may include PAIN; PARESTHESIAS; PARESIS; or HYPESTHESIA.

The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.

The functional hereditary units of INSECTS.

Infections of the BRAIN; SPINAL CORD; or MENINGES caused by HELMINTHS (parasitic worms).

The medial terminal branch of the sciatic nerve. The tibial nerve fibers originate in lumbar and sacral spinal segments (L4 to S2). They supply motor and sensory innervation to parts of the calf and foot.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.

An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

Treatment of muscles and nerves under pressure as a result of crush injuries.

The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.

An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.

Differentiated tissue of the central nervous system composed of NERVE CELLS, fibers, DENDRITES, and specialized supporting cells.

Refers to animals in the period of time just after birth.

Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)

A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.

Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.

Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

Unsuccessful surgical treatment of hip dislocation in congenital sensory neuropathy with anhidrosis. A case report. (1/1736)

A six-year-old girl with congenital sensory neuropathy with anhidrosis (CSNA) presented with bilateral hip dysplasia and subluxation on the right side. Conservative treatment of the hips by closed reduction and a plaster cast was unsuccessful. When aged seven years the patient had an intertrochanteric varus rotation osteotomy on the right side, but subluxation was again evident after five months. A Salter-type pelvic osteotomy was carried out followed by immobilisation, but one year later subluxation was present in the right hip and dislocation in the left. At the age of nine years, the right femoral head resembled a Charcot joint, although walking ability was preserved. In patients with CSNA, surgery may not always be advisable. (+info)

Phase II study of cisplatin and vinorelbine as first-line chemotherapy in patients with carcinoma of the uterine cervix. (2/1736)

PURPOSE: To evaluate the activity and toxicity of the combination of cisplatin (80 mg/m2 day 1) and vinorelbine (25 mg/m2 days 1 and 8) in patients with carcinoma of the uterine cervix that has not been previously treated with chemotherapy. PATIENTS AND METHODS: Fifty patients with cervical cancer were enrolled onto this study (27 stage IB-III, 23 stage IVB-recurrent). A two-stage optimal Simon design was applied. Thirteen responders of 29 treated patients were required to proceed beyond the first stage, and 28 responders were needed overall. RESULTS: Hematologic toxicity was mild, with neutropenia being the most frequent side effect. Nonhematologic toxicity was frequent but never severe; one patient had grade 3 peripheral neurotoxicity. Objective responses were recorded for 32 patients (64%): 11 patients (22%) achieved a complete response (CR) and 21 patients (42%) achieved a partial response (PR). The response rate was 81.5% in patients with IB-III stage (25.9% CR rate) and 43.5% in patients with IVB-recurrent disease (17.4% CR rate). Responses were seen both in stage IVB patients (one CR and two PRs, for an overall rate of 37.5%) and in patients with recurrent disease (three CRs + four PRs, for an overall rate of 46.7%). CONCLUSION: The combination of cisplatin and vinorelbine is an active regimen in the treatment of patients with early-stage and advanced carcinoma of the uterine cervix. The hematologic and nonhematologic toxicity of this combination is mild. (+info)

Clinicopathological features of Churg-Strauss syndrome-associated neuropathy. (3/1736)

We assessed the clinicopathological features of 28 patients with peripheral neuropathy associated with Churg-Strauss syndrome. Initial symptoms attributable to neuropathy were acute painful dysaesthesiae and oedema in the dysaesthetic portion of the distal limbs. Sensory and motor involvement mostly showed a pattern of mononeuritis multiplex in the initial phase, progressing into asymmetrical polyneuropathy, restricted to the limbs. Parallel loss of myelinated and unmyelinated fibres due to axonal degeneration was evident as decreased or absent amplitudes of sensory nerve action potentials and compound muscle action potentials, indicating acute massive axonal loss. Epineurial necrotizing vasculitis was seen in 54% of cases; infiltrates consisted mainly of CD8-positive suppressor/cytotoxic and CD4-positive helper T lymphocytes. Eosinophils were present in infiltrates, but in smaller numbers than lymphocytes. CD20-positive B lymphocytes were seen only occasionally. Deposits of IgG, C3d, IgE and major basic protein were scarce. The mean follow-up period was 4.2 years, with a range of 8 months to 10 years. Fatal outcome was seen only in a single patient, indicating a good survival rate. The patients who responded well to the initial corticosteroid therapy within 4 weeks regained self-controlled functional status in longterm follow-up (modified Rankin score was < or = 2), while those not responding well to the initial corticosteroid therapy led a dependent existence (P < 0.01). In addition the patients with poor functional outcomes had significantly more systemic organ damage caused by vasculitis (P < 0.05). Necrotizing vasculitis mediated by cytotoxic T cells, leading to ischaemic changes, appears to be a major cause of Churg-Strauss syndrome-associated neuropathy. The initial clinical course and the extent of systemic vasculitic lesions may influence the long-term functional prognosis. (+info)

Neurological complications of neurofibromatosis type 1 in adulthood. (4/1736)

Neurofibromatosis type 1 (NF1) is a genetic disease with a wide range of neurological manifestations. To examine these, and to evaluate neurological morbidity in adulthood of patients with NF1, we studied a hospital-based series of 158 patients that included 138 adult patients aged >18 years and 20 children. NF1 evaluation included a multidisciplinary clinical and a clinically oriented radiological investigation. Neurological events occurring during childhood (in both children and adults of the series) and adulthood were recorded. One or several neurological manifestations have been observed in 55% of patients (adults and children) (n = 87). These included: headache (28 patients); hydrocephalus (7); epilepsy (5); lacunar stroke (1); white matter disease (1); intraspinal neurofibroma (3); facial palsy (1); radiculopathy (5); and polyneuropathy (2). Tumours included: optic pathway tumours (20); meningioma (2); cerebral glioma (3); and malignant peripheral nerve sheath tumours (6). Life-threatening complications were observed in five adults and included four malignant peripheral nerve sheath tumours and one meningioma. Pain was the leading symptom in 11 adults and was related to malignant peripheral nerve sheath tumours, complications of intraspinal neurofibromas, subcutaneous neurofibromas and peripheral nerve neurofibromas. NF1 in adults was not associated with other disabling or life-threatening neurological complications. Symptomatic optic pathway tumours, cerebral gliomas, symptomatic aqueductal stenosis and spinal compression due to intraspinal NF were observed exclusively during childhood. In this series, the predominant neurological features of adults with NF1 were chronic pain and malignant peripheral nerve sheath tumours. (+info)

Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data. (5/1736)

In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and kidney of affected cats revealed contamination with the ionophor salinomycin. Epidemiologic and clinical data were collected from 823 cats, or about 1% of the cats at risk. In 21 affected cats, postmortem examination was performed. The affected cats had acute onset of lameness and paralysis of the hindlimbs followed by the forelimbs. Clinical and pathologic examination indicated a distal polyneuropathy involving both the sensory and motor nerves. (+info)

Ten- to 15-year outcome of surgery for lumbar disc herniation: radiographic instability and clinical findings. (6/1736)

The most appropriate treatment for radiculopathy associated with disc pathology is still controversial. Since 1934, surgical treatment has consisted of hemilaminectomy and removal of the herniated material. Many authors believe that these procedures may cause degenerative spondylosis and vertebral instability. Several surgical methods have been proposed, but the long-term effects are still being debated. In addition there appear to be few well-designed outcome studies on the management of this disease. In the present study, 150 patients were selected for surgery with strict criteria and all treated with the standard technique. The series was evaluated by subjective analyses (Roland questionnaire; 120 patients), objective examinations (68 patients - 56.6%) and radiographic studies including dynamic views (analyzed by the Taillard and Boxall methods) to establish the presence of vertebral instability (50 patients - 41.6%). The subjective and objective analyses showed a high rate of good results. Radiographic studies showed vertebral instability in 30 cases, but only 9 were symptomatic. Recurrences were not observed and only a few patients suffered from leg pain. The standard procedure for lumbar disc herniation showed good results at 10- and 15-year follow-up. (+info)

Successful treatment of IgM paraproteinaemic neuropathy with fludarabine. (7/1736)

OBJECTIVES: To evaluate the response of four patients with IgM paraproteinaemic neuropathy to a novel therapy-pulsed intravenous fludarabine. BACKGROUND: The peripheral neuropathy associated with IgM paraproteinaemia usually runs a chronic, slowly progressive course which may eventually cause severe disability. Treatment with conventional immunosuppressive regimens has been unsatisfactory. Fludarabine is a novel purine analogue which has recently been shown to be effective in low grade lymphoid malignancies. METHODS: Four patients were treated with IgM paraproteinaemic neuropathy with intravenous pulses of fludarabine. Two of the four patients had antibodies to MAG and characteristic widely spaced myelin on nerve biopsy and a third had characteristic widely spaced myelin only. The fourth had an endoneurial lymphocytic infiltrate on nerve biopsy and a diagnosis of Waldenstrom's macroglobulinaemia. RESULTS: In all cases subjective and objective clinical improvement occurred associated with a significant fall in the IgM paraprotein concentration in three cases. Neurophysiological parameters improved in the three patients examined. The treatment was well tolerated. All patients developed mild, reversible lymphopenia and 50% mild generalised myelosuppression, but there were no febrile episodes. CONCLUSION: Fludarabine should be considered as a possible treatment for patients with IgM MGUS paraproteinaemic neuropathy. (+info)

Vasculitic polyradiculopathy in systemic lupus erythematosus. (8/1736)

A 22 year old woman with recently diagnosed systemic lupus erythematosus presented with subacute progressive areflexic paraparesis, electrophysiologically identified as a pure axonal polyradiculopathy. Sural nerve biopsy disclosed necrotising vasculitis. A striking radiological feature was marked enhancement of the cauda equina with gadolinium. (+info)

In the peripheral nervous system (PNS), the disease is more severe. While most nervous system diseases affect either central ... nervous system (CNS) or PNS, this disease affects both, but the changes in the PNS lead to death. This occurs by axonal disease ... neuropathological features in the central and peripheral nervous system". Modern Pathology. 29 (9): 962-976. doi:10.1038/ ... Genetic diseases and disorders, Syndromes affecting the nervous system). ...

https://en.wikipedia.org/wiki/Andermann_syndrome

Central nervous system disease Peripheral neuropathy "Nervous System Diseases - Neurologic Diseases". MedlinePlus. Retrieved ... "Central nervous system: Structure, function, and diseases". 22 December 2017. "Peripheral Nervous System". www.indiana.edu. " ... The nerves connect to the peripheral nervous system. The peripheral nervous system connects to the muscles and glands and sends ... Nervous system diseases, also known as nervous system or neurological disorders, refers to a small class of medical conditions ...

https://en.wikipedia.org/wiki/Nervous_system_disease

They could include diseases or disorders in the central nervous system or peripheral nervous system. Examples of neuropathic ... or changes in hormonal balances associated with aging Terminal illness Itch can originate in the peripheral nervous system ( ... or in the central nervous system (neuropathic, neurogenic, or psychogenic). Itch originating in the skin is known as ... for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010". ...

https://en.wikipedia.org/wiki/Itch

Some patients with systemic vasculitis will have their multi-organ disease spread to the peripheral nervous system; this is ... It can be as part of a systemic problem or can exist as a single-organ issue only affecting the peripheral nervous system (PNS ... Vasculitic neuropathy is a peripheral neuropathic disease. In a vasculitic neuropathy there is damage to the vessels that ... Infectious diseases: hepatitis B, hepatitis C, human immunodeficiency virus (HIV), cytomegalovirus, lyme disease, human T-cell- ...

https://en.wikipedia.org/wiki/Vasculitic_neuropathy

Neurology works with diseases of the central and peripheral nervous systems, such as amyotrophic lateral sclerosis (ALS) and ... Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its ... the central nervous system (defined as the brain and spinal cord), and the peripheral nervous system. In many species - ... Neurosurgery and psychosurgery work primarily with surgical treatment of diseases of the central and peripheral nervous systems ...

https://en.wikipedia.org/wiki/Neuroscience

Wight, P. a. L. (1960). A histological study of the spinal cord and peripheral nervous system in scrapie disease of sheep ( ... As these involve the animal's nervous system he moved onto the field of neuropathology. In 1956, he returned to Britain to work ... The Histopathology of Marek's Disease Oregon Disease in Turkeys Who's Who in Commerce and Industry vol 14 SILLER, WALTER G. " ... Here he mainly worked on mainstream African animal diseases such as Heartwater and Rabies. ...

https://en.wikipedia.org/wiki/P._A._L._Wight

... a broad term describing any disease process which affects the peripheral nervous system. However, neuropathies may be due to ... 20 (5 Peripheral Nervous System Disorders): 1274-92. doi:10.1212/01.CON.0000455881.83803.a9. PMID 25299282. S2CID 35635940. " ... Neuritis (/njʊəˈraɪtɪs/) is inflammation of a nerve or the general inflammation of the peripheral nervous system. Inflammation ... CS1 maint: others, Articles with short description, Short description is different from Wikidata, Peripheral nervous system ...

https://en.wikipedia.org/wiki/Neuritis

It is a disease of the peripheral nervous system, caused by a mutation in one of two myelin genes. Roussy and Lévy published ... his investigations on the role of the thalamus and the autonomic nervous system. During World War I he was chief of neurology ... A hereditary disease that is usually first noticed in infancy. Named with Dr. Gabrielle Lévy. Les psychonévroses de guerre, ... "Roussy-Lévy disease": spinocerebellar degeneration with muscular atrophy of the lower limbs, sensory ataxia, plus other ...

https://en.wikipedia.org/wiki/Gustave_Roussy

... is a group of autosomal dominant inherited neurological diseases that affect the peripheral nervous system particularly on the ... They accumulate in the peripheral nervous system where HSAN manifest, but not in the central nervous system in mice bearing a ... Peripheral nervous system disorders, Rare diseases, Neurogenetic disorders). ... However, information on the expression of the gene in the peripheral nervous system is still lacking. In fruit fly (Drosophila ...

https://en.wikipedia.org/wiki/Hereditary_sensory_and_autonomic_neuropathy_type_I

It is a disease of the peripheral nervous system, caused by a mutation in one of two myelin genes. Roussy and Lévy published ... She suffered from a severe disease of the nervous system, which she diagnosed herself, but she remained lucid until the end. ... An obituary published in the Journal of Nervous and Mental Disease describes her as having "qualities of intense application ... "Gabrielle Lévy, M.d". The Journal of Nervous and Mental Disease. 81 (6): 725. June 1935. doi:10.1097/00005053-193506000-00066. ...

https://en.wikipedia.org/wiki/Gabrielle_Charlotte_Lévy

This coordination can be disrupted by damage or diseases of the central nervous system, peripheral nerves or autonomic nervous ... refers to urinary bladder problems due to disease or injury of the central nervous system or peripheral nerves involved in the ... peripheral nerve damage, Parkinson's disease, or other neurodegenerative diseases. Neurogenic bladder can be diagnosed through ... Peripheral nerves can also be damaged as a complication of major surgery of the pelvis, such as for removal of tumors. The ...

https://en.wikipedia.org/wiki/Neurogenic_bladder_dysfunction

Hence, he believed the entire body-all the organs, glands and peripheral nervous system-was implicated in the natural disease ... The Journal of Nervous and Mental Disease. 200 (12): 1022-30. doi:10.1097/NMD.0b013e318275cf19. PMID 23197117. S2CID 41939669 ... Bleuler later expanded his new disease concept into a monograph in 1911, which was finally translated into English in 1950. ... According to some scholars, the disease has always existed only to be 'discovered' during the early 20th century. The ...

https://en.wikipedia.org/wiki/History_of_schizophrenia

These diagnostic tests of the peripheral nervous system, especially useful in evaluating diseases of the muscles, nerves, and ... Electrodiagnostic medicine focuses only on the peripheral nervous system and not the central nervous system. Whereas a clinical ... the pathophysiology along with clinical methods used to diagnose diseases involving both central and peripheral nervous systems ... Clinical neurophysiology is a medical specialty that studies the central and peripheral nervous systems through the recording ...

https://en.wikipedia.org/wiki/Clinical_neurophysiology

Peripheral nervous system diseases may be further categorized by the type of nerve cell (motor, sensory, or both) affected by ... complex disorders linked by the degeneration of neurons in either the peripheral nervous system or the central nervous system. ... Neurodegenerative diseases of the central nervous system can affect the brain and/or spinal cord. This article will cover the ... Disease: amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Huntington's disease (HD), spinal muscular atrophy (SMA ...

https://en.wikipedia.org/wiki/Epigenetics_of_neurodegenerative_diseases

... especially as relating to the pathophysiology underlying diseases of the central and peripheral nervous system. It is the ...

https://en.wikipedia.org/wiki/Clinical_Neurophysiology_(journal)

Reilly, Mary M.; Murphy, Sinéad M.; Laurá, Matilde (2011). "Charcot-Marie-Tooth disease". Journal of the Peripheral Nervous ... System. 16 (1): 1-14. doi:10.1111/j.1529-8027.2011.00324.x. ISSN 1529-8027. PMID 21504497. "First clinical trial for Charcot ... She began to study neuromuscular disease, in particular Charcot-Marie-Tooth disease. In 2004, she found that Vitamin C could be ... Reilly has served as President of the British Peripheral Nerve Society and the International Peripheral Nerve Society. In 2015 ...

https://en.wikipedia.org/wiki/Mary_Reilly_(academic)

... diseases of the peripheral nervous system, dermatological diseases, respiratory and other disorders. The marine climate has hot ... Here you can treat degenerative, inflammatory and diarthritic rheumatic diseases, post-traumatic states, ...

https://en.wikipedia.org/wiki/Neptun,_Romania

... peripheral, and autonomic nervous systems. Stroke Parkinson's disease Alzheimer's disease Huntington's disease Multiple ... History of neuroscience Outline of the human nervous system Action potential Acetylcholinesterase Central nervous system (CNS) ... Neurophysiology is the study of the function (as opposed to structure) of the nervous system. Brain mapping Electrophysiology ... Neural oscillation Molecular neuroscience is a branch of neuroscience that examines the biology of the nervous system with ...

https://en.wikipedia.org/wiki/Outline_of_neuroscience

Vascular diseases, Peripheral nervous system disorders, Sensitivities). ... the cardiovascular system, the nervous system, and circulation control system. Orthostatic intolerance is divided, roughly ... OI can be a subcategory of dysautonomia, a disorder of the autonomic nervous system occurring when an individual stands up. ...

https://en.wikipedia.org/wiki/Orthostatic_intolerance

A neuromuscular disease is any disease affecting the peripheral nervous system (PNS), the neuromuscular junction, or skeletal ... a part of the central nervous system. However, the anterior horn is also part of the motor unit. Diseases that affect the ... Prognosis and management vary by disease.[citation needed] List of neuromuscular disorders Motor neuron diseases Neuromuscular ... such as the failure of the body's system for absorbing vitamin B-12. Diseases of the motor end plate include myasthenia gravis ...

https://en.wikipedia.org/wiki/Neuromuscular_disease

Peripheral nervous system disorders, Cytomegalovirus-associated diseases, HIV/AIDS, All stub articles, Nervous system disease ... that CMV polyradiculomyelopathy should be treated with both ganciclovir and foscarnet in patients who develop the disease while ...

https://en.wikipedia.org/wiki/CMV_polyradiculomyelopathy

The following diseases can be treated here: orthopedic and traumatic, nervous, rheumatological, peripheral nervous system, skin ...

https://en.wikipedia.org/wiki/Uniejów

... motor neuron disease, peripheral neuropathy, and other diseases of the nervous system". J. Neuroimmunol. 56 (1): 27-33. doi: ... 1989). "Total, anti-viral, and anti-myelin IgG subclass reactivity in inflammatory diseases of the central nervous system". J. ... 2006). "Anti-ganglioside antibodies in coeliac disease with neurological disorders". Digestive and Liver Disease. 38 (3): 183-7 ... Antibodies to ganglioside are found to be elevated in coeliac disease. Recent studies show that gliadin can cross-link to ...

https://en.wikipedia.org/wiki/Antiganglioside_antibodies

... (CIDP) is an acquired autoimmune disease of the peripheral nervous system ... Journal of the Peripheral Nervous System. 10 (3): 329-337. doi:10.1111/j.1085-9489.2005.10311.x. PMID 16221292. S2CID 24896124 ... Ultrasound of the peripheral nerves may show swelling of the affected nerves. Magnetic resonance imaging can also be used in ... Fatigue has been identified as common in CIDP patients, but it is unclear how much this is due to primary (due to the disease ...

https://en.wikipedia.org/wiki/Chronic_inflammatory_demyelinating_polyneuropathy

A synaptopathy is a disease of the brain, spinal cord or peripheral nervous system relating to the dysfunction of synapses. ... Some diseases of unknown etiology have been proposed to be synaptopathies. Examples include autism spectrum disorder and ... Increasing knowledge of the genetic basis of these diseases has linked proteins to the function of the synapse. Age-related ... Another example of synaptopathy occurs in the auditory system. This cochlear synaptopathy has been seen after prolonged noise ...

https://en.wikipedia.org/wiki/Synaptopathy

... a genetically and clinically heterogeneous group of inherited disorders of the peripheral nervous system characterized by ... Abrams, Charles K.; Rash, John E. (2009). "Connexins in the Nervous System". In Harris, Andrew; Locke, Darren (eds.). Connexins ... Classifications of Charcot-Marie-Tooth disease refers to the types and subtypes of Charcot-Marie-Tooth disease (CMT), ... 1997). "New Mutations in the X-Linked Form of Charcot-Marie-Tooth Disease". European Neurology. 37 (1): 38-42. doi:10.1159/ ...

https://en.wikipedia.org/wiki/Charcot–Marie–Tooth_disease_classifications

... (CMT) is a hereditary motor and sensory neuropathy of the peripheral nervous system characterized ... Peripheral nervous system disorders, Cytoskeletal defects, Syndromes affecting the nervous system). ... "Neurophysiologic abnormalities in children with Charcot-Marie-Tooth disease type 1A". Journal of the Peripheral Nervous System ... In 2010, CMT was one of the first diseases where the genetic cause of a particular patient's disease was precisely determined ...

https://en.wikipedia.org/wiki/Charcot–Marie–Tooth_disease

... even expert neurologists experienced in the diagnosis of diseases of the peripheral nervous system may not previously have ... Motor neuron diseases, Rare diseases, Unsolved problems in neuroscience, All stub articles, Nervous system disease stubs). ... Facial onset sensory and motor neuronopathy, often abbreviated FOSMN, is a rare disorder of the nervous system in which sensory ... In common with many neurological diseases, there is no one 'test' for FOSMN. The diagnosis can be notoriously difficult, mainly ...

https://en.wikipedia.org/wiki/Facial_onset_sensory_and_motor_neuronopathy

Charcot-Marie-Tooth (CMT) is the most frequent heritable disorder of the peripheral nervous system (a neuronal disease) and is ... Diabetes, a metabolic disease, induces oxidative stress, which triggers a build up of mitochondrial tRNA mutations. It has also ... Depletion of the other substrate of aminoacyl-tRNA synthetases, the cognate tRNA, may be relevant to certain diseases, e.g. ... Certain diseases' causation (such as neuronal pathologies, cancer, disturbed metabolic conditions, and autoimmune disorders) ...

https://en.wikipedia.org/wiki/Aminoacyl_tRNA_synthetase

Demyelinating diseases can be divided in those affecting the central nervous system (CNS) and those affecting the peripheral ... The demyelinating diseases of the peripheral nervous system include:[citation needed] Guillain-Barré syndrome and its chronic ... A demyelinating disease is any disease of the nervous system in which the myelin sheath of neurons is damaged. This damage ... Both myelinoclastic and leukodystrophic modes of disease may result in lesional demyelinations of the central nervous system. ...

https://en.wikipedia.org/wiki/Demyelinating_disease

Rare diseases, Neurodegenerative disorders, Peripheral nervous system disorders). ... Parkinson's disease and multiple system atrophy, being the first process to give an objective diagnosis of Multiple System ... The region in question includes the SHC2 gene which, in mice and rats, appears to have some function in the nervous system. The ... Many people affected by MSA experience dysfunction of the autonomic nervous system, which commonly manifests as orthostatic ...

https://en.wikipedia.org/wiki/Multiple_system_atrophy

Axons in the central nervous system do not regenerate after injury the same way that axons in the peripheral nervous system do ... Mutations to the MAG gene are implicated in demyelination diseases such as multiple sclerosis. ... Lopez PH (2014). "Role of myelin-associated glycoprotein (siglec-4a) in the nervous system". Advances in Neurobiology. 9: 245- ... Lopez PH (2014). "Role of myelin-associated glycoprotein (siglec-4a) in the nervous system". Advances in Neurobiology. 9: 245- ...

https://en.wikipedia.org/wiki/Myelin-associated_glycoprotein

Child's Nervous System. 25 (1): 13-20. doi:10.1007/s00381-008-0701-x. PMID 18818933. S2CID 30117644. Carter CJ (November 2009 ... "The peripheral blood mononuclear cell microRNA signature of coronary artery disease". Biochemical and Biophysical Research ...

https://en.wikipedia.org/wiki/Mir-198_microRNA_precursor_family

Coniine acts directly on the central nervous system through inhibitory action on nicotinic acetylcholine receptors. In high ... The alkaloid content found in C. maculatum also affects the thermoregulatory centre by a phenomenon called peripheral ... Avian Diseases. 34 (2): 433-437. doi:10.2307/1591432. JSTOR 1591432. PMID 2369382. Blamey, M.; Fitter, R.; Fitter, A. (2003). ...

https://en.wikipedia.org/wiki/Conium_maculatum

... sprue Cenani-Lenz syndactylism Cennamo-Gangemi syndrome Central core disease Central diabetes insipidus Central nervous system ... late infantile Cervical cancer Cervical hypertrichosis neuropathy Cervical hypertrichosis peripheral neuropathy Cervical ribs ... Marie-Tooth disease type 1A Charcot-Marie-Tooth disease type 1B Charcot-Marie-Tooth disease type 1C Charcot-Marie-Tooth disease ... Marie-Tooth disease type 2C Charcot-Marie-Tooth disease type 2D Charcot-Marie-Tooth disease type 4A Charcot-Marie-Tooth disease ...

https://en.wikipedia.org/wiki/List_of_diseases_(C)

"Peripheral Solutions to Peripheral Development: The Case of Early 20th Century Romania" (PDF file), in Journal of World Systems ... culminating in Brătianu's arrival to power after the premier fell victim to a nervous disease -, Stere replaced Petre Poni at ... At the time, a physician who examined him noted that he had suffered a nervous breakdown, and had him moved to a prison ...

https://en.wikipedia.org/wiki/Constantin_Stere

The involvement of both the central and peripheral nervous system in COVID‑19 has been reported in many medical publications. ... Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a virus, the severe acute respiratory syndrome ... The virus is not detected in the central nervous system (CNS) of the majority of COVID-19 patients with neurological issues. ... The cells of the central nervous system, the microglia, neurons, and astrocytes, are also involved in the release of pro- ...

https://en.wikipedia.org/wiki/COVID-19

The peripheral nervous system is made up of these spinal roots, nerves, and ganglia. The dorsal roots are afferent fascicles, ... Spinal cord injury can also be non-traumatic and caused by disease (transverse myelitis, polio, spina bifida, Friedreich's ... The spinal cord is the main pathway for information connecting the brain and peripheral nervous system. Much shorter than its ... These rootlets form the demarcation between the central and peripheral nervous systems.[citation needed] Generally, the spinal ...

https://en.wikipedia.org/wiki/Spinal_cord

... peripheral nervous system, liver, spleen, and bone marrow. Inside cells under normal conditions, lysosomes convert, or ... Members of this group include Niemann-Pick disease, Fabry disease, Krabbe disease, Gaucher disease, Tay-Sachs disease, ... Xanthomatosis Niemann-Pick disease "Lipid Storage Diseases Fact Sheet". National Institute of Neurological Disorders and Stroke ... Enzyme replacement therapy is available mainly to treat Fabry disease and Gaucher disease and people with these types of ...

https://en.wikipedia.org/wiki/Lipid_storage_disorder

... s are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where ... "Histamine H3 Receptor as a Potential Target for Cognitive Symptoms in Neuropsychiatric Diseases." Behavioural Brain Research ... Central nervous system Peripheral nervous system Heart Lungs Gastrointestinal tract Endothelial cells Like all histamine ... because it is linked to the central nervous system and its regulation of other neurotransmitters. Examples of such disorders ...

https://en.wikipedia.org/wiki/Histamine_H3_receptor

The sympathoadrenal system is a physiological connection between the sympathetic nervous system and the adrenal medulla and is ... Schrier, Robert W (1999). Atlas of Diseases of the Kidney. Philadelphia, PA: Blackwell Science. pp. Volume 3. Bray, George A ( ... Together, the effects increase peripheral blood pressure, but decrease central blood pressure. This can have larger effects on ... the brain acts on the central nervous system by crossing the blood-brain barrier and affecting the sympathetic nervous system. ...

https://en.wikipedia.org/wiki/Sympathoadrenal_system

... peripheral nervous system, and central nervous system. B. Burgdorferi does not produce toxins. Therefore, many of the signs and ... Halperin JJ (June 2008). "Nervous system Lyme disease". Infectious Disease Clinics of North America. 22 (2): 261-74, vi. doi: ... Lyme disease organizations at Curlie CDC - Lyme Disease Lyme Disease Tests - Lab Tests Online NIH - Lyme Disease NICE ... Lyme disease can affect several body systems and produce a broad range of symptoms. Not everyone with Lyme disease has all of ...

https://en.wikipedia.org/wiki/Lyme_disease

Although the disease is the basis for this type of neurolysis, other diseases such as peripheral neuralgia or vasospastic ... A neurolytic agent such as alcohol, phenol, or glycerol is typically injected into the nervous system. Chemical neurolysis ... Peripheral nerves move (glide) across bones and muscles. A peripheral nerve can be trapped by scarring of surrounding tissue ... "External Neurolysis (peripheral nerve disorders) , Department of Neurosurgery". med.nyu.edu. Retrieved 2020-04-24. Bahn, Bret M ...

https://en.wikipedia.org/wiki/Neurolysis

The mGluRs perform a variety of functions in the central and peripheral nervous systems: For example, they are involved in ... Platt SR (March 2007). "The role of glutamate in central nervous system health and disease--a review". Veterinary Journal. 173 ... Also, some researchers have suggested that activation of mGluR4 could be used as a treatment for Parkinson's disease. Most ... More recent reports on ionotropic glutamate receptors able to couple to metabotropic transduction systems suggest that ...

https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor

... is a motor speech disorder resulting from damage to peripheral nervous system (cranial or spinal nerves) or ... Demyelinating disorders Infectious/Inflammatory Degenerative disorders Metabolic Neoplastic Traumatic Vascular Diseases Flaccid ... lower motor neuron system. Depending on which nerves are damaged, flaccid dysarthria affects respiration, phonation, resonance ...

https://en.wikipedia.org/wiki/Flaccid_dysarthria

Also affected are the hypothalamus, spinal cord and peripheral nervous system-autonomic dysfunction. The European Federation of ... as diseases of the nervous system, code 31.8. Diagnostic tests can be used to establish some features of the condition and ... Several areas of the nervous system (such as the autonomic nervous system and numerous regions of the brain) can be affected by ... Lewy pathology affects the peripheral autonomic nervous system; autonomic dysfunction is observed less often in AD, ...

https://en.wikipedia.org/wiki/Dementia_with_Lewy_bodies

"Interim Treatment Guidance for Central Nervous System and Parameningeal Infections Associated with Injection of Contaminated ... Additionally, very common adverse effects, occurring in more than 10% of people, include peripheral edema, headaches, trouble ... August 2016). "Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases ... "Voriconazole". The American Society of Health-System Pharmacists. Retrieved 8 December 2017. Kendig EL, Wilmott RW, Chernick V ...

https://en.wikipedia.org/wiki/Voriconazole

... s, All stub articles, Nervous system drug stubs). ... COMT inhibitors are indicated for the treatment of Parkinson's disease in combination with levodopa and an aromatic L-amino ... Entacapone and opicapone are peripheral inhibitors, unable to cross the blood-brain barrier. Tolcapone is able to cross the ... Scott, Lesley J. (2016-08-06). "Opicapone: A Review in Parkinson's Disease". Drugs. 76 (13): 1293-1300. doi:10.1007/s40265-016- ...

https://en.wikipedia.org/wiki/Catechol-O-methyltransferase_inhibitor

Neurosteroids are synthesized in the central nervous system (CNS) and the peripheral nervous system (PNS) from cholesterol and ... Neuropsychiatric Disease and Treatment. 1 (4): 329-43. PMC 2424120. PMID 18568113. Rudolph U, Knoflach F (Sep 2011). "Beyond ... Baulieu EE (1997). "Neurosteroids: of the nervous system, by the nervous system, for the nervous system". Recent Progress in ... GABA is a major inhibitory neurotransmitter in the central nervous system. Upon binding, it triggers the GABAA receptor to open ...

https://en.wikipedia.org/wiki/GABAA_receptor_positive_allosteric_modulator

A prion disease called kuru has been traced to this. Brain-computer interface Central nervous system disease List of ... Some basic types of responsiveness such as reflexes can be mediated by the spinal cord or peripheral ganglia, but sophisticated ... Except for a few primitive organisms such as sponges (which have no nervous system) and cnidarians (which have a nervous system ... and neurology is the medical discipline that diagnoses and treats diseases of the nervous system. The brain is also the most ...

https://en.wikipedia.org/wiki/Brain

Wood-allum, Clare A.; Shaw, Pamela J. (2014). "Thyroid disease and the nervous system". Neurologic Aspects of Systemic Disease ... "nervous system" and -pathy, "disease of") without modifier usually means peripheral neuropathy. Neuropathy affecting just one ... non-sensory nervous system (i.e., the autonomic nervous system), affecting mostly the internal organs such as the bladder ... Testing for small-fiber peripheral neuropathies often relates to the autonomic nervous system function of small thinly- and ...

https://en.wikipedia.org/wiki/Peripheral_neuropathy

July 2015). "Structural and functional features of central nervous system lymphatic vessels". Nature. 523 (7560): 337-41. doi: ... ISBN 978-0-323-54800-7. Anrather J (2017-01-01). "Chapter 28 - Pathophysiology of the Peripheral Immune Response in Acute ... Ischemic Stroke". In Caplan LR, Biller J, Leary MC, Lo EH (eds.). Primer on Cerebrovascular Diseases (Second ed.). San Diego: ...

https://en.wikipedia.org/wiki/Deep_cervical_lymph_nodes

Central nervous system effects such as hallucinations or confusion have been observed in rare cases, attributed mostly to ... This side effect is more likely to occur in people with pre-existing cardiac disease, or with the use of other medicines known ... Levander S, Ståhle-Bäckdahl M, Hägermark O (1 September 1991). "Peripheral antihistamine and central sedative effects of single ... These have also been confirmed in both recent and past studies to have no adverse effects on the liver, blood, nervous system, ...

https://en.wikipedia.org/wiki/Hydroxyzine

Central nervous system involvement may cause strokes or seizures.[citation needed] Renal system: Kidney involvement is common ... The medical eponyms Kussmaul disease or Kussmaul-Maier disease reflect the seminal description of the disease in the medical ... Neurologic system: Nerve involvement may cause sensory changes with numbness, pain, burning, and weakness (peripheral ... These manifestations result from ischemic damage to affected organs, often the skin, heart, kidneys, and nervous system. ...

https://en.wikipedia.org/wiki/Polyarteritis_nodosa

Wheeler G, Ntounia-Fousara S, Granda B, Rathjen T, Dalmay T (April 2006). "Identification of new central nervous system ... "Differential microRNA expression in peripheral blood mononuclear cells from Graves' disease patients". The Journal of Clinical ...

https://en.wikipedia.org/wiki/Mir-431_microRNA_precursor_family

"Peripheral and Central Nervous System Advisory Committee Background Package on Azilect" (PDF). FDA. Retrieved December 7, 2011 ... that it actually prevented the death of the dopaminergic neurons that characterize Parkinson's disease and slowed disease ... Parkinson's disease is characterized by the death of cells that produce dopamine, a neurotransmitter. An enzyme called ... Selegiline Ladostigil Akao Y, Maruyama W, Yi H, Shamoto-Nagai M, Youdim MB, Naoi M (June 2002). "An anti-Parkinson's disease ...

https://en.wikipedia.org/wiki/Rasagiline

"Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T ... host disease. The specific cell-surface markers for Tr1 cells in humans and mice are CD4+ CD49b+LAG-3+ CD226+ from which LAG-3+ ... Tr1 cells are self or non-self antigen specific and their key role is to induce and maintain peripheral tolerance and suppress ... Phase I/II of clinical trials of Tr1 cell treatment concerning Crohn's disease have been successful and appear to be safe and ...

https://en.wikipedia.org/wiki/Type_1_regulatory_T_cell

Spinocerebellar degeneration is a rare inherited neurological disorder of the central nervous system characterized by the slow ... Many SCAs below fall under the category of polyglutamine diseases, which are caused when a disease-associated protein (i.e., ... peripheral neuropathy, seizures, among others. As with other forms of ataxia, SCA frequently results in atrophy of the ... Both onset of initial symptoms and duration of disease are variable. If the disease is caused by a polyglutamine trinucleotide ...

https://en.wikipedia.org/wiki/Spinocerebellar_ataxia

... and pain affect the vestibular system and the central nervous system which can cause the symptom of disequilibrium. Balance ... vascular system, fluid or blood volume, spinal cord, peripheral nerves, or body electrolytes. Dizziness can accompany certain ... Medical conditions that often have dizziness as a symptom include: Benign paroxysmal positional vertigo Ménière's disease ... This sensation can originate in the inner ear or other motion sensors, or in the central nervous system. Neurologic disorders ...

https://en.wikipedia.org/wiki/Dizziness

These highly specialized glial cells wrap and electrically insulate axons in the peripheral and central nervous system, ... This line of research helps us to understand the molecular mechanisms of human neurological diseases in which genetic mutations ... A major focus of their research is on neuron-glia interactions that result in the assembly of myelin in the nervous system. ... focuses on molecular mechanisms of synapse development and function in the mammalian central nervous system. For that purpose, ...

https://en.wikipedia.org/wiki/Max_Planck_Institute_for_Experimental_Medicine

has_disease_location some (peripheral nervous system or part of some peripheral nervous system) ... has_disease_location some (peripheral nervous system or part of some peripheral nervous system) ... peripheral nervous system disease. Go to external page http://www.ebi.ac.uk/efo/EFO_0009387 Copy ... A disease involving the peripheral nervous system. [ https://orcid.org/0000-0002-6601-2165 ] ...

https://www.ebi.ac.uk/ols/ontologies/efo/terms?short_form=EFO_0009387

Symptomatic treatment of painful diseases of the peripheral nervous system with a combination preparation of thiamine, ... Peripheral Nervous System Diseases / drug therapy* * Peripheral Nervous System Diseases / etiology * Pyridoxine / ...

https://pubmed.ncbi.nlm.nih.gov/1330858/

Results of search for su:{Peripheral nervous system diseases} Refine your search. *. Availability. * Limit to currently ... The physiology of peripheral nerve disease / Austin J. Sumner. by Sumner, Austin J. ... Peripheral neuropathies : report of a WHO study group [meeting held in Geneva from 1 to 4 October 1979] by WHO Study Group on ... by WHO Study Group on Peripheral Neuropathies , World Health Organization.. Series: Organisation mondiale de la Santé. Série de ...

https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=su:%7BPeripheral%20nervous%20system%20diseases%7D

Learn about neuropathy and more than 100 other types of peripheral nerve disorders. ... Peripheral nerves are nerves outside your brain and spinal cord. ... Peripheral Nervous System Diseases (National Institutes of ... What are peripheral nerve disorders?. Peripheral nerve disorders happen when one or more peripheral nerves are damaged. Damaged ... What Are the Parts of the Nervous System? (Eunice Kennedy Shriver National Institute of Child Health and Human Development) ...

https://medlineplus.gov/peripheralnervedisorders.html

"Journal of the Peripheral Nervous System. 7 (4): 229-32. doi:10.1046/j.1529-8027.2002.02030.x. PMID 12477169.. ... Also, the disease can be diagnosed by a positive "middle finger test", where resisted middle finger extension produces pain. ... "Examination of peripheral nerve injuries: an anatomical approach. Stuttgart: Thieme. p. 62. ISBN 978-3-13-143071-7. .. ... The chief complaint of this disease is usually pain in the dorsal aspect of the upper forearm, and any weakness described is ...

https://en.wikipedia.org/wiki/Radial_tunnel_syndrome

Peripheral Nervous System Diseases. Neuromuscular Diseases. Nervous System Diseases. Polyradiculoneuropathy. Autoimmune ... Diseases of the Nervous System. Demyelinating Diseases. Autoimmune Diseases. Immune System Diseases. ... Genetic and Rare Diseases Information Center resources: Chronic Graft Versus Host Disease Chronic Inflammatory Demyelinating ... Condition or disease Intervention/treatment Phase Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Biological: ...

https://clinicaltrials.gov/ct2/show/NCT04281472

Nervous System Lyme Borreliosis; Neuroborreliosis, Borrelia burgdorferi; Peripheral Nervous System Lyme Disease. On-line free ... Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms ... and late persistent disease. Neuroborreliosis, infection of the nervous system by B. burgdorferi, may occur during early ... Concurrent infection of the central nervous system by borrelia burgdorferi and bartonella henselae: evidence for a novel tick- ...

https://lookfordiagnosis.com/cases.php?term=Lyme+Neuroborreliosis&filter=lyme%7Clyme+borreliosis%7Cborreliosis%7Clyme+disease&values=0.782673%7C0.644809%7C0.448349%7C0.252042&lang=1&from=10

Disease should be diagnosed by using the Brighton Collaboration case definitions and cerebrospinal fluid IgM reactivity. ... neurotropic disease; MoH, Ministry of Health; PNS, autoimmune neurologic disease with peripheral nervous system involvement; YF ... autoimmune neurologic disease with central nervous system involvement; CSF, cerebrospinal fluid; IQR, interquartile range; NA, ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ...

https://wwwnc.cdc.gov/eid/article/27/6/20-4170-t1

... and peripheral nerves has been recognized in several clinical and postmortem case reports and series by Combe, Addison, and ... Metz J. Cobalamin deficiency and the pathogenesis of nervous system disease. Annu Rev Nutr. 1992. 12:59-79. [QxMD MEDLINE Link] ... Vitamin B12 deficiency and nervous system disease in HIV infection. Arch Neurol. 1993 Aug. 50(8):807-11. [QxMD MEDLINE Link]. ... Vitamin B-12 role in the peripheral and central nervous systems. The neurologic manifestation of cobalamin deficiency is less ...

https://www.medscape.com/answers/1152670-77132/which-age-groups-are-at-highest-risk-for-vitamin-b-12-related-neurological-disorders

Peripheral Nervous System Diseases [‎5]‎. Personnel Management [‎47]‎. Personnel Selection [‎6]‎. Pharmaceutical Preparations ...

https://extranet.who.int/iris/restricted/handle/10665/155715/browse?rpp=20&sort_by=-1&type=mesh&etal=-1&starts_with=O&order=ASC

Categories: Peripheral Nervous System Diseases Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ...

https://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Peripheral+Nervous+System+Diseases&parentid=17951&catid=19746

Symptoms of autoimmune diseases can include fatigue, aching joints and muscles, inflammation, hair loss, and rashes. Learn more ... Peripheral nervous system manifestations in systemic autoimmune diseases. Maedica (Bucur). 2014;9(3):289-294. ... Guillain-Barré syndrome (GBS) results from an immune system attack on the peripheral nervous system, usually after a bacterial ... Celiac Disease Celiac disease occurs when the immune system attacks the lining of the small intestines in response to gluten, a ...

https://www.verywellhealth.com/autoimmune-disease-symptoms-3232847

epidemiological studies; central nervous system; rabies; sheep; peripheral nervous system diseases; strain differences; signs ... disease reservoirs; disease prevalence; disease transmission; digestive system diseases; anti-infective agents; Portugal. ... type III secretion system; intestinal mucosa; mutants; digestive system diseases; Escherichia coli O157; disease resistance; ... Aujeszky disease; isomers; disease resistance; immune response; immune system; pathogenesis; biochemical mechanisms; disease ...

https://pubag.nal.usda.gov/?f%5Bjournal_name%5D%5B%5D=Veterinary+microbiology&f%5Bpublication_year_rev%5D%5B%5D=7993-2007&f%5Bsource%5D%5B%5D=2007+v.125+no.3-4

... neurochemistry and molecular mechanisms of the central and peripheral nervous systems in health and disease. ... musculoskeletal system, peripheral nervous system and vascular supply to the trunk, head and neck, limbs, and back. ... of human diseases and understanding how physiological systems interact in order to maintain homeostasis in health and disease. ... organization and current research-based concepts of the human nervous system. Emphasis on fundamental knowledge of the ...

https://medicine.iu.edu/anatomy-cell-biology-physiology/education/graduate-degrees/courses

Peripheral Nervous System Diseases/diagnosis, Leprosy/complications, Palpation/methods @font-face{font-family:Roboto;font- ...

https://bvsalud.org/en/multimedia?q=hansen+or+hanseniase+or+lepra+or+leprosy&filter=descriptor:Palpation+AND+descriptor:Doen%C3%A7as+do+Sistema+Nervoso+Perif%C3%A9rico+AND+descriptor:Palpa%C3%A7%C3%A3o+AND+media_collection_filter:Instituto+Lauro+de+Souza+Lima

... is the most common clinical genetic disease of the peripheral nervous system. Although many studies have focused on elucidating ... The biological function enrichment analysis suggested that myelin sheath, axon, peripheral nervous system, mitochondrial ... a systematic analysis of biology to decode the underlying pathological molecular mechanisms and the mechanism of its disease ... peripheral nervous system development, myelination in peripheral nervous system, and peripheral nervous system axon ...

https://www.hindawi.com/journals/bmri/2020/1353516/

Central and Peripheral Nervous System, Neuromuscular Disease & Disorders w/Dr. Esfahani. day:. Wednesday. date:. 08/03/2022. ... ANES) Residents Split Curriculum - CA0/1s: Central and Peripheral Nervous System, Neuromuscular Disease & Disorders w/Dr. ... Infectious Diseases Infectious Diseases & International Health Infectious Diseases Training Program Journal Club LCME M.D./Ph.D ... Microbiology, Immunology and infectious Diseases Graduate Program Microbiology, Immunology, and Cancer Biology Molecular Cell ...

https://www.healthsystem.virginia.edu/events/index.cfm?viewformat=month&viewtype=som&startdate=08/02/2022&filterdepartment=2

Peripheral Nervous System Diseases Medicine & Life Sciences 100% * Drug Therapy Medicine & Life Sciences 55% ... Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting toxicity, negatively affecting both quality of ... N2 - Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting toxicity, negatively affecting both ... AB - Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting toxicity, negatively affecting both ...

https://mayoclinic.pure.elsevier.com/en/publications/recent-developments-of-novel-pharmacologic-therapeutics-for-preve

... the precise mechanism inducing dysmylination in NPC1 disease is still unclear. In the present study, a quantitative evaluation ... Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting in a neurodegenerative ... and histopathologic changes confirm peripheral nervous system myelin abnormalities in the feline model of niemann-pick disease ... Metabolic Brain Disease. Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting ...

https://www.semanticscholar.org/paper/Decreased-expression-of-myelin-gene-regulatory-in-C-Yan-Lukas/2a212482cb154eb33d9dca0d5e90558b817c0547

This is supposed to be an autoimmune disease of the peripheral nervous system. Would taking this help or hurt my condition ... Maximized immune system: The primary vehicle the immune system uses for destroying invaders is enzymes. Macrophages, for ... What they do is, by removing circulating immune complexes, take load off the immune system so that your immune system can work ... At first, these CICs may be neutralized by the immune system, then eliminated through the lymphatic system and the kidneys. ...

https://www.jonbarron.org/article/proteolytic-enzyme-formula

New research indicates that inflammation plays a causal role in the array of neurologic changes associated with Lyme disease, ... of patients with Lyme disease develop peripheral and central nervous system involvement, often accompanied by debilitating and ... About 15% of patients with Lyme disease develop peripheral and central nervous system involvement, often accompanied by ... only when lymphocytic inflammatory lesions were also observed in both the central nervous system and peripheral nervous system ...

https://www.news-medical.net/news/20150417/Inflammation-plays-causal-role-in-neurologic-changes-associated-with-Lyme-disease.aspx

Chronic carbon-disulfide exposure resulted in central and peripheral nervous system dysfunction, gastrointestinal changes, ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... cardiovascular disease, and mental illness. Studies have shown that workers exposed to carbon- disulfide show frequent ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=carbon+disulfide&f1=%2A&Startyear=&Adv=0&terms=1&EndYear=&Limit=10000&sort=&D1=10&PageNo=5&RecNo=41&View=f&

MS is a disease of the central nervous system. This includes the brain and spinal cord. GBS is a disease of the peripheral ... since damaged myelin of the peripheral nervous system regenerates more effectively than that of the central nervous system. The ... nervous system (the nerves outside the brain and spinal cord). MS does not cause a sudden and catastrophic paralysis of the ... How can we propagate this to the general public that we have a better system available to treat COVID. What is use of having a ...

https://hpathy.com/feedback/letters-to-the-editor-feedback-from-aug-2021/

... of which the R220Pfs*23 carrier also had neurologic manifestations in the central nervous system. We then constructed GJB1 ... All 4 probands presented typical early-onset peripheral neuropathy, of which the R220Pfs*23 carrier also had neurologic ... manifestations in the central nervous system. We then constructed GJB1 expression vectors and performed cell biological ... All four probands presented typical early-onset peripheral neuropathy, ...

https://www.frontiersin.org/articles/10.3389/fnins.2022.972288/full

This Institute studies all the scientific and medical fields to do with the central and peripheral nervous system, its ... The economic impact of these diseases accounts for a third of the human cost of diseases in Europe. ... plasticity and aging of the nervous system. Genes interact with the environment at every stage when the functional nervous ... Progress in our knowledge of the symptoms and causes of nervous system disorders has enabled us to determine their extent and ...

https://aviesan.fr/en,/aviesan/accueil/menu-header/instituts-thematiques-multi-organismes/neurosciences-sciences-cognitives-neurologie-psychiatrie

Peripheral and Central Nervous System Implications in Celiac Disease Women in Digestive Diseases: At the Forefront 2022 ... Peripheral and Central Nervous System Implications in Celiac Disease. Saturday, November 20, 2021 8:30 AM - 1 PM None ... 2022 Safadi Lecture: Emerging Gene Therapies for the Central Nervous System. Thursday, August 18, 2022 11 AM - 1 PM 900 E 57th ... Videos Updates in IBD and Annual Updates in Digestive Diseases Neurological and Psychological Implications in Celiac Disease ...

https://www.vumedi.com/channel/uchicago-medicine/tab/events-154/

... is a genetically heterogeneous hereditary peripheral neuropathy. Brain volumetry and diffusion tensor imaging (DTI) were ... Transient central nervous system white matter abnormality in X-linked Charcot-Marie-Tooth disease. Ann. Neurol. 2002, 52, 429- ... a disorder affecting the central and peripheral nervous systems. Cell Tissue Res. 2015, 360, 659-673. [Google Scholar] [ ... However, the central nervous system (CNS) has been implicated in several CMT patients with GJB1 and MFN2 mutations [4,5], and ...

https://www.mdpi.com/2077-0383/10/21/4945

Chronic exposure may result in poisoning of the nervous system, liver damage, and peripheral vascular disease, which could ... Agency for Toxic Substance and Disease Registration. Agency for Toxic Substance and Disease Registration. ... Organochloride insecticides affect the peripheral nervous system (PNS) through dermal absorption, inhalation, and ingestion. ... Methyl mercury is the most toxicological form of the element and, by its accumulation in the central nervous system (CNS), may ...

https://www.atsdr.cdc.gov/training/toxmanual/modules/4/lecturenotes.html

Charcot-Marie-Tooth Disease (CMT), also known as hereditary motor sensory neuropathy (HMSN), was first reported by French neurologists Charcot and Marie and British neurologist Tooth in 1886 [ 1 , 2 ]. (hindawi.com)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting toxicity, negatively affecting both quality of life and disease outcomes. (elsevier.com)
Some patients with Lyme disease also show evidence of demyelinating neuropathy and slowing nerve conduction. (news-medical.net)
X-linked Charcot-Marie-Tooth Disease type 1(CMT1X) is the second most common form of inherited peripheral neuropathy that is caused by mutations in the gap junction beta-1 (GJB1) gene. (frontiersin.org)
All four probands presented typical early-onset peripheral neuropathy, of which the R220Pfs * 23 carrier also had neurologic manifestations in the central nervous system. (frontiersin.org)
Aims/hypothesis: The aim of this study was to evaluate the effects on diabetic peripheral neuropathy (DPN) of a long-term intensive lifestyle intervention (ILI) programme designed to achieve and maintain weight loss. (elsevier.com)
Comorbidities for peripheral neuropathy were excluded. (biomedcentral.com)
These results confirm the role of peripheral neuropathy in Gaucher pain and demonstrate that skin denervation is as a constitutive feature of the disorder. (biomedcentral.com)
showed a high prevalence of peripheral neuropathy (16.5%) in a cohort of GD1 patients followed for 2 years [ 9 ]. (biomedcentral.com)
Serial electrophysiological and immunological findings showed that diabetes was involved in the immune-mediated mechanism of peripheral neuropathy. (elsevier.com)
GJB1 disorders are typically characterized by peripheral motor and sensory neuropathy with or without fixed CNS abnormalities and/or acute, self-limited episodes of transient neurologic dysfunction (especially weakness and dysarthria). (nih.gov)
Peripheral neuropathy typically manifests in affected males between ages five and 25 years. (nih.gov)
GJB1 Charcot-Marie-Tooth neuropathy with or without central nervous system dysfunction (CMT1X) should be suspected in an individual with the following clinical findings, electrophysiologic findings, and family history. (nih.gov)
Disease or damage involving the SCIATIC NERVE , which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY ). (nih.gov)
Acute peripheral nervous system involvement associated with Lyme disease includes radiculopathy, cranial neuropathy (Bell palsy, Figure 5 ), and mononeuropathy multiplex. (cfp.ca)
Neurologic symptoms of late Lyme disease can include encephalomyelitis, peripheral neuropathy, or encephalopathy. (cfp.ca)
It is associated with many diseases, including diabetic peripheral neuropathy, postherpetic neuralgia, human immunodeficiency virus-related disorders, and chronic radiculopathy. (mayoclinicproceedings.org)
Have you ever heard of diabetic peripheral neuropathy? (nomonausea.com)
A basic peripheral neuropathy workup is recommended in cases in which the diagnosis is uncertain. (medscape.com)
Neuropathy refers to pain and miscommunication between the central nervous system and the rest of your body. (alleviatepain.com)
Peripheral neuropathy occurs when the nerves of the extremities, such as the legs, hands, and feet, are affected. (alleviatepain.com)
When something happens to the nerves of your involuntary nervous system, which controls circulation and the heart, as well as digestion and bladder function, you have autonomic neuropathy. (alleviatepain.com)

Peripheral nerve disorders happen when one or more peripheral nerves are damaged. (medlineplus.gov)
Peripheral nerve disorders are very common. (medlineplus.gov)
Diabetes is the most common cause of peripheral nerve disorders. (medlineplus.gov)
Some examples of peripheral nerve disorders from physical injury include complex regional pain syndrome and brachial plexus injuries . (medlineplus.gov)
What are the symptoms of peripheral nerve disorders? (medlineplus.gov)
How are peripheral nerve disorders diagnosed? (medlineplus.gov)
Can peripheral nerve disorders be prevented? (medlineplus.gov)
Like many other degenerative disorders, hereditary peripheral neuropathies have been difficult to treat. (hindawi.com)
This graduate course uses a multidisciplinary approach to integrate the basic with the clinical neurosciences in understanding the human nervous system and select neurological disorders. (iu.edu)
Charcot-Marie-Tooth (CMT) disease is a genetically heterogeneous group of disorders characterized by progressive distal muscle weakness and atrophy, usually with foot deformities and sensory loss, as well as decreased tendon reflexes ( Szigeti and Lupski, 2009 ). (frontiersin.org)
Progress in our knowledge of the symptoms and causes of nervous system disorders has enabled us to determine their extent and frequency better. (aviesan.fr)
These conditions can be inherited in autosomal dominant, autosomal recessive, and X-linked patterns, and each group of disorders exhibits variable clinical presentation, age of onset, degree of severity, and disease progression. (ggc.org)
One can see a neurosurgeon if you have any symptoms like birth-defects, trauma to brain or spine due to some shock or accident, brain tumours, vascular disorders, infections in the brain or spine, stroke, or degenerative diseases of the spine like multiple sclerosis. (practo.com)
Surgeons who are specialized in examining, diagnosing, and treating diseases and disorders related to the nervous system through medications and surgeries are called Neurosurgeons. (practo.com)
Both Neurosurgeons and Neurologists are medical doctors who are specialized and well trained in Neurology and treat patients who are suffering from nervous system disorders. (practo.com)
We provide to our customers our in depth know-how in the evaluation of treatment for neurodegenerative diseases and neurological disorders. (neurofit.com)
Otolaryngologists are physicians trained in the medical and surgical management and treatment of patients with diseases and disorders of the ear, nose, throat (ENT), and related structures of the head and neck. (ac.ir)
Neurology is a branch of medicine dealing with disorders of the nervous system. (ac.ir)
Neurosurgery (or Neurological Surgery) is the medical specialty concerned with the prevention, diagnosis, treatment, and rehabilitation of disorders which affect any portion of the nervous system including the brain, spinal cord, peripheral nerves, and extra-cranial cerebrovascular system. (ac.ir)
Neurologist in Multan - Neurology is the branch of medical sciences that deals with the disease, disorders of the nervous system. (hamariweb.com)
He treats the disorders and diseases that affect the brain, spinal cord, and nerves, such as: strokes or Cerebrovascular disease, Demyelinating diseases, Headache disorders, Infections of the brain and peripheral nervous system, Movement disorders, Speech disorders, Neurodegenerative disorders are all included in the treatment domain of Neurologist. (hamariweb.com)
Definition of neurology: a science involved in the study of the nervous systems, especially of the diseases and disorders affecting them. (neurosciencenews.com)
Parkinson's disease (PD) is a neurodegenerative disorder, affectingmotor and non-motor functions of the central and peripheral nervous systems, including the dopaminergic neurons of the substantia nigra.The incidence of PD is one of the highest among all neurological disorders. (neuramedy.com)
The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. (weedworldmagazine.org)
In this way you are preventing disorders with your nervous system which means that you are preventing the burning feet in your feet. (instiks.com)

What are peripheral nerves? (medlineplus.gov)
Your peripheral nerves branch off from your brain and spinal cord and connect to all parts of your body, including your muscles and organs. (medlineplus.gov)
The areas most commonly affected by leprosy are the superficial peripheral nerves, skin, mucous membranes of the upper respiratory tract, anterior chamber of the eyes, and the testes. (medscape.com)
For Schwann cells in particular, the mycobacteria bind to the G domain of the alpha-chain of laminin 2 (found only in peripheral nerves) in the basal lamina, causing demyelination. (medscape.com)
The pathology found in the dorsal root ganglia and sensory nerves may explain the localized pain and motor deficits that Lyme disease patients experience close to the origin of the tick bite. (news-medical.net)
Histopathologic findings consist of degeneration of myelinated fibers in peripheral nerves and chromatolysis and loss of sensory neurons in spinal ganglia. (msdvetmanual.com)
Peripheral nerves control sensory, motor and autonomic functions and can regenerate though very slowly. (uctv.tv)

A logical approach to the treatment of cerebral lupus is to build a treatment strategy around the various possible pathogeneses: (1) ischemia due to thromboses secondary to the antiphospholipid syndrome, (2) small-vessel noninflammatory proliferative vasculopathy due to cell-mediated immune mechanisms, and (3) antibody-mediated damage to the spinal cord and optic nerve-akin to Devic disease. (medscape.com)
Central nervous system involvement includes lymphocytic meningitis and, rarely, encephalomyelitis (parenchymal inflammation of brain or spinal cord, with focal abnormalities). (cfp.ca)
Spinal muscular atrophy (SMA) is a rare genetic disease affecting the central nervous system, peripheral nervous system and voluntary muscle movement. (nm.org)
A neurosurgeon is a doctor with a specialization in diagnosis and treatment of brain, spinal cord and nerve-related diseases. (practo.com)
No, a neurologist cannot treat birth-defects in the nervous system, but a neurosurgeon can operate on such defects present since birth in the brain and spinal cord in infants and children. (practo.com)
In other cases of ADEM, modest visual or motor deficits may persist, as may sphincter abnormalities in patients with spinal cord disease. (medscape.com)
CB1 receptors, which are mostly concentrated in the central nervous system - your brain and spinal cord and mostly in areas of the central nervous system that have to do with processing pain messages from the body[12].CB2 receptors, which are more evenly distributed throughout the body and are especially prevalent in the immune system[12]. (siciley.com)
In its early years, the Institute's staff focused on dealing with long-term effects and complications of injuries of the skull, brain and spinal cord, the peripheral and in particular autonomic nervous system. (kiev.ua)
One of the most significant and complex network of the body nervous system deals with the brain and spinal cord. (hamariweb.com)
2016). A DYNC1H1 mutation in autosomal dominant spinal muscular atrophy shows the potential of pharmacological inhibition of histone deacetylase 6 as a treatment for disease associated cellular phenotypes . (city.ac.uk)
it is occasionally used for repairing damaged peripheral joints and rarely used to correct spinal deformities as it involves significant morbidity. (medscape.com)
The leukemia cells can spread outside the blood to other parts of the body, including the central nervous system (brain and spinal cord ), skin, and gums . (cancer.gov)
Stroke (brain hemorrhage/infarction), Diseases of arteries and veins of the brain and spinal cord, brain tumors. (neurocitihospital.com)

Hereditary neuropathies, including Charcot-Marie-Tooth disease, affect the peripheral nervous system and include symptoms of muscle weakness, decreased reflexes, foot deformities, and loss of sensation. (ggc.org)

Your genes , including changes in your genes or conditions that you inherit from your parents, such as Charcot-Marie-Tooth disease . (medlineplus.gov)
Charcot-Marie-Tooth Disease (CMT) is the most common clinical genetic disease of the peripheral nervous system. (hindawi.com)
The Dear Medical Professional Letter has a brief description of Charcot-Marie-Tooth disease and the neurotoxic drug list. (cmtausa.org)

Journal of the Peripheral Nervous System , 9 (2), 92-97. (elsevier.com)
Scaioli, V , Andreetta, F & Mantegazza, R 2004, ' Unusual neurophysiological and immunological findings in myasthenia gravis: A case report ', Journal of the Peripheral Nervous System , vol. 9, no. 2, pp. 92-97. (elsevier.com)
Journal Of The Peripheral Nervous System , 21(3), pp. 261-262. (city.ac.uk)

A pronounced neurodegeneration and glia activation in the olfactory system of NPC1−/− animals is demonstrated, accompanied by sensory deficits, which underlines the critical role and location of the OB as a possible entrance gate for noxious substances. (semanticscholar.org)
Clinical symptoms of LNB of the peripheral nervous system may include facial nerve palsy, neurogenic pain radiating along the back into the legs and feet, limb pain, sensory loss, or muscle weakness. (news-medical.net)
Specifically, our work has demonstrated that there is a complex interplay between immune responses and sensory pathways and that chronic pain following nervous system damage results from a neuroimmune imbalance leading to chronic neuroinflammation and long-lasting neuropathic pain. (edu.au)
The peripheral nervous system includes sensory receptors. (hamariweb.com)
The control of balance requires the integration of information from multiple sensory and motor systems by the central nervous system (CNS). (cdc.gov)
Because the balance system is so complex, it can be impaired by a large number of disease processes affecting any of the multiple sensory inputs, neural processing centers, or motor outputs. (cdc.gov)
it is the sensory system that provides the dominant input about movement and sense of balance. (medicalsymptomsguide.com)

Treatment for symptoms depends on the type of peripheral nerve disorder you have, where it is, and how severe. (medlineplus.gov)
Less threatening flare-ups may be treated with as much as 100 mg or as little as 10 mg prednisone orally (PO) daily (QD) (or other agents in equivalent dosage), again tapering gradually according to clinical symptoms, with an increase of 10-20% during the taper if clinical disease flares again. (medscape.com)
Inflammation, which can cause tissue and organ damage, is the main trigger behind the symptoms of autoimmune diseases . (verywellhealth.com)
These signs and symptoms are common to most autoimmune diseases. (verywellhealth.com)
About 15% of patients with Lyme disease develop peripheral and central nervous system involvement, often accompanied by debilitating and painful symptoms. (news-medical.net)
Pain is one of the most disabling symptoms of Gaucher disease. (biomedcentral.com)
Sometimes called Kugelberg-Welander disease, the most common symptoms of this type of SMA include clumsiness, trouble walking and climbing steps, fine tremor and muscle weakness. (nm.org)
In endemic areas, the disease should be ruled out in all patients who develop unexplained neurological symptoms. (who.int)
As with any chronic disease, patient education is vital to familiarize the patient with the symptoms, course, and treatment of the disease. (medscape.com)
Regular exercise helps reduce the symptoms and may slow the progress of the disease. (medscape.com)
Typically the diagnosis of valvular disease and dysfunction has been previously established but emergency physicians must be alert to the presenting signs and symptoms to aid the undiagnosed patient, and with bedside echocardiography becoming more common, initial diagnosis will occur more commonly in the ED. (mhmedical.com)
Also, partial presentations (an absence of some of the following signs/symptoms) do not necessarily imply less severe disease. (cdc.gov)
Symptoms of the disease include periodic episodes of rotary vertigo or dizziness. (medicalsymptomsguide.com)
Symptoms caused by mercury, such as general fatigue may be caused by many disease states so dental fillings are rarely suspected. (sohointegrativemedicine.com)

Chronic carbon - disulfide exposure resulted in central and peripheral nervous system dysfunction, gastrointestinal changes, cardiovascular disease, and mental illness. (cdc.gov)
Myopathies are associated with weakness and dysfunction of predominantly proximal skeletal muscles, and wasting may occur in later stages of disease. (ggc.org)
Neuropathic pain (NP), caused by a primary lesion or dysfunction in the nervous system, affects approximately 4 million people in the United States each year. (mayoclinicproceedings.org)
β-amyloid i.c.v injection induces learning deficits and a dysfunction of the cholinergic system. (neurofit.com)

Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting in a neurodegenerative process in patients mainly at an early age, although some patients may start with manifestation in adult. (semanticscholar.org)
In neurodegenerative diseases, stroke, and infection, NETs in human blood samples has been found to be positively or negatively associated with clinical outcome [ 16 - 18 ]. (aging-us.com)
Alzheimer's disease is the most common age-related neurodegenerative disorder, characterized by the progressive degeneration of neuronal populations and the simultaneous loss of memory and cognitive functions. (neurofit.com)
Alpha Cognition Inc. is a clinical stage, biopharmaceutical company dedicated to developing treatments for under-served neurodegenerative diseases, such as Alzheimer's Dementia and Amyotrophic Lateral Sclerosis (ALS). (alphacognition.com)
Its use for the treatment of neurodegenerative diseases has been patented by the Company and granted an Orphan Drug Designation. (alphacognition.com)

3) 'Encephalopathy and polyneuropathy are the most common diseases related to neurology following the exposure to low levels of environmental substances. (harvoa.org)

Repair and rebuild the cardiovascular system. (jonbarron.org)
According to the results of questionnaire and electrocardiogram, all subjects were free of hypertension, hyperlipemia, cardiovascular disease, and diabetes mellitus. (hindawi.com)
In addition to renal disease, cardiovascular effects, and reproductive toxicity, lead may cause irreversible neurologic damage. (cdc.gov)
150/90 mmHg), significant cardiovascular impairment or event within previous 12 months or patients who had active autoimmune disease or a medical condition that required immunosuppression. (merck.com)

Our Neurology series is designed for the practitioner managing conditions and disease of the central and peripheral nervous systems. (audio-digest.org)
She writes across the biomedical sciences, but holds strong interests in rheumatology, neurology, autoimmune diseases, genetics, and the intersection of broader social, cultural and emotional contexts with biomedical topics. (the-rheumatologist.org)
Best Neurology Treatment in Ludhiana, Punjab, A neurologist is a medical expert who specializes in checking, diagnosing, and treating nervous system problems. (neurocitihospital.com)

Clinical studies supporting this approach were generally performed in lupus nephritis because of its frequency, severity, and quantifiable improvement or deterioration, still, the same treatment approaches are generally applied to other organ systems, including the central and peripheral nervous systems and muscular disease. (medscape.com)
Tapering to an every-other-day steroid regimen reduces adverse effects substantially but probably will not be successful until the clinical disease is relatively stable. (medscape.com)
Modulation of the immune system via B-cell depletion is entering clinical practice. (medscape.com)
It is the most common clinical single-gene genetic disease of the peripheral nervous system with high clinical heterogeneity and genetic heterogeneity, with a prevalence of about 1/2500 [ 3 , 4 ]. (hindawi.com)
Although this classification helps in describing disease progression and prognosis, studies of GD clinical history showed the existence of a continuum of phenotypes, ranging from the severe GD2 to the asymptomatic GD1 form [ 3 ]. (biomedcentral.com)
Therefore, we proposed a hypothesize that peripheral neutrophils probably elevated after SAH and the elevation of neutrophils count perhaps associated with unfavorable SAH clinical outcome. (aging-us.com)
We reviewed the clinical manifestations and outcome of 20 cases of neurobrocellosis out of 1375 patients with brucellosis admitted to the infectious diseases ward of a tertiary hospital in Hamedan, Islamic Republic of Iran. (who.int)
In modern clinical practice, physicians personally assess patients in order to diagnose, prognose , treat, and prevent disease using clinical judgment. (owiki.org)
While rates of endometrial carcinoma continue to rise globally, patients with advanced or recurrent disease have limited options available to them once the disease progresses following platinum-based chemotherapy," said Dr. Gregory Lubiniecki, Vice President, Oncology Clinical Research, Merck Research Laboratories. (merck.com)

A condition referred to as "chronic Lyme disease" has been suggested by a small number of medical practitioners, but its existence is viewed with scepticism by the mainstream medical community. (cfp.ca)

Leprosy is a chronic granulomatous disease principally affecting the skin and peripheral nervous system. (medscape.com)
Despite this discovery, leprosy was not initially thought to be an infectious disease. (medscape.com)
Leprosy is included among the Neglected Tropical Diseases as designated by the World Health Organization. (medscape.com)
Leprosy is not a highly infectious disease. (medscape.com)
Leprosy is not generally spread by means of direct contact through intact skin, although the most vulnerable are close contacts of patients with untreated multibacillary disease. (medscape.com)

However, the diagnosis of SS with neurologic involvement is sometimes difficult, and central nervous system (CNS) manifestations have been described rarely. (lww.com)
Molecular testing is useful to confirm the diagnosis and to identify the disease causing mutations within a family to allow for carrier testing and prenatal diagnosis. (ggc.org)
In the context of significant weight loss, serum creatinine levels may overestimate eGFR, leading to a delayed diagnosis of chronic kidney disease (CKD) and late referral to a specialist. (medscape.com)
The field includes medical diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular heart disease and electrophysiology. (ac.ir)
Internal Medicine or General Medicine is the medical specialty dealing with the prevention, diagnosis, and treatment of adult diseases. (ac.ir)
Medicine is the science and practice of establishing the diagnosis , prognosis , treatment , and prevention of disease . (owiki.org)
Medicine is the science and practice of the diagnosis, prognosis, treatment, and prevention of disease. (owiki.org)

The invention also includes the use of these cells for the treatment of neurological conditions such as Parkinson's disease. (justia.com)

A condition where damage to the peripheral nervous system (including the peripheral elements of the autonomic nervous system) is associated with chronic ingestion of alcoholic beverages. (umassmed.edu)

The disease mimicked relapsing-remitting multiple sclerosis (MS) in 10 patients and primary progressive MS in 13 patients. (lww.com)
Lewy body (ies) (disease) (G31.8) · multiple sclerosis (G35) · neurosyphilis (A52.1) · niacin deficiency [pellagra] (E52) · polyarteritis nodosa (M30.0) · systemic lupus erythematosus (M32. (who.int)

A type of glial cell of the peripheral nervous system that helps separate and insulate nerve cells called Schwann cells may cause the tumor as a result of overproduction. (medicalsymptomsguide.com)

AL amyloidosis often occurs in persons with monoclonal gammopathy and typically affects the heart and kidneys, although the peripheral and autonomic nervous systems, gastrointestinal tract, and other organs may be involved. (medscape.com)
The purpose of this study was to examine the effects of moderate intensity interval training from the change of the autonomic nervous activity. (hindawi.com)
It is clarified that the exercise as well as activating the vagus nerve activity stimulates the total autonomic nervous activity. (hindawi.com)
Autonomic nervous activity decreases with age. (hindawi.com)
it shows the imbalance of the autonomic nervous activity. (hindawi.com)
For keeping people healthy, it is necessary to find an exercise to suppress the sympathetic activity and to increase the autonomic nervous activity especially vagus nerve activity. (hindawi.com)
Then, we demonstrate the effectiveness of this training from the change of the autonomic nervous activity by moderate intensity interval training in an index of the heart rate. (hindawi.com)

Our research is focused on neuropathic pain, a particularly debilitating form of chronic pain caused by a lesion or disease affecting the somatosensory nervous system. (edu.au)

Infections , such as HIV and Lyme disease . (medlineplus.gov)
Infections of patients with this bacterium manifests as the disease cholera. (sens.org)
AA amyloidosis affects persons with chronic infections or autoinflammatory diseases and primarily involves the kidneys. (medscape.com)

Autoimmune diseases , such as rheumatoid arthritis and lupus . (medlineplus.gov)

Alopecia areata is a condition in which the immune system attacks the hair follicles, causing hair loss. (verywellhealth.com)
Antiphospholipid syndrome (APS) is a condition in which antibodies -proteins produced by the immune system-damage the cells lining the blood vessels. (verywellhealth.com)
Celiac disease occurs when the immune system attacks the lining of the small intestines in response to gluten , a protein found in wheat, rye, barley, and many prepared foods. (verywellhealth.com)
Clean up your immune system. (jonbarron.org)
The vast majority of metabolic enzymes in your body, the enzymes that regulate everything from liver function to the immune system, are proteases, or proteolytic enzymes. (jonbarron.org)
The principal aim of our research is to understand the relationship between the nervous system and the immune system, with particular emphasis on how immune cells and their mediators affect neuropathic pain, and to assess immunotherapeutic approaches. (edu.au)
When the immune system detects toxic inorganic metals in body tissues, it sees these as "foreign" and proceeds to destroy them, turning on its own tissues, hence the term "autoimmune. (sohointegrativemedicine.com)

It has been mainly considered as nociceptive pain secondary to skeletal involvement but it is described even in the absence of bone disease without a clear explanation. (biomedcentral.com)
Cardiac involvement associated with Lyme disease includes intermittent atrioventricular heart block, often involving the atrioventricular node (although heart block can occur at multiple levels), and sometimes myopericarditis. (cfp.ca)
Fifty-one patients had peripheral nervous system involvement (PNS). (lww.com)
At least 36 proteins have been identified in humans, with 17 showing systemic involvement and the rest presenting as localized diseases. (medscape.com)

In case of peripheral lesion, it is the anal tone and the contraction that varied the symptomatology. (bvsalud.org)

Dr. Kaposi's work is also interesting in the context of the current challenge of classifying patients with complex and overlapping multisystem autoimmune diseases. (the-rheumatologist.org)
There is growing evidence that the effects of amalgam in a person's teeth could contribute to autoimmune diseases. (sohointegrativemedicine.com)

Also there are other causes which are not so common as the previously mentioned causes, but also there are people who have burning feet caused by chronic kidney disease, injuries, stings and bites from insects, deficiencies of calcium, B vitamins, thiamine and folic acid, peripheral vascular disease, burning feet syndrome and traumas. (instiks.com)

Genes interact with the environment at every stage when the functional nervous system is forming and contributes to its plasticity over time. (aviesan.fr)
This panel consists of 144 genes that have been associated with inherited neuromuscular diseases. (ggc.org)

Our group studies genetic diseases that confer a high predisposition to develop cancer. (germanstrias.org)

The biological function enrichment analysis suggested that myelin sheath, axon, peripheral nervous system, mitochondrial function, various metabolic processes, and autophagy played important roles in CMT development. (hindawi.com)

In certain cases, the cause of peripheral nerve disorder is not known. (medlineplus.gov)
The advent of next-generation sequencing (NGS) has expanded and accelerated the analysis of various diseases at the level of genome, especially in heterogeneous disorder groups such as CMT [ 9 , 10 ]. (hindawi.com)
This effort was driven by the memory of their son, Greyson , who died of Krabbe disease, a rare inherited degenerative disorder of the central and peripheral nervous systems. (susannahfox.com)
Vertigo is usually caused by a disorder in the central or peripheral vestibular system. (medicalsymptomsguide.com)
Meniere's disease is a disorder of the inner ear that can cause affect hearing and balance. (medicalsymptomsguide.com)

It is being developed as a new generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease, with minimal gastrointestinal side effects and novel routes of administration. (alphacognition.com)

Control of brain and nerve diseases : a world-wide challenge. (who.int)
This program discusses peripheral nerve diseases, including the anatomy of the central and peripheral nervous systems by Dr. Maggie Waung. (uctv.tv)

On successful completion of this module you will be able to describe the structure and functions of the auditory, visual, and central and peripheral nervous system and outline pathophysiology of common diseases of these systems. (mdx.ac.uk)
We could not elucidate pathophysiology of systemic diseases like lupus without first looking for commonalities and distinctions among patients," says Dr. Salmon. (the-rheumatologist.org)

Since loss of myelin is considered as a main pathogenetic factor, the precise mechanism inducing dysmylination in NPC1 disease is still unclear. (semanticscholar.org)
GJB1- encoded GJB1 protein, also named connexin-32 (Cx32), is widely expressed in peripheral myelin and is specifically located at uncompacted folds of Schwann cell cytoplasm around the nodes of Ranvier and Schmidt-Lanterman incisures ( Abrams and Freidin, 2015 ). (frontiersin.org)

Graduate-level neuroscience course providing an introduction to terminology, pathways, organization and current research-based concepts of the human nervous system. (iu.edu)
I have long known my future career will lie somewhere in the field of Neuroscience, but only due to my internship last summer did I realize my passion lies in research and development of therapeutics for neurological diseases. (sens.org)
However, differentiation to a specific neural cell population is required to realize many of the potential applications of ES cells in regenerative medicine of the central nervous system and neuroscience. (justia.com)
Neuroscience is the scientific study of nervous systems. (neurosciencenews.com)

Few of the central and peripheral nervous system diseases are seizures, brain stroke, epilepsy, Alzheimer's disease, and myasthenia gravis. (practo.com)
MCI is known as a risk factor for Alzheimer's disease and dementia. (neurofit.com)

Crohn's disease is an inflammatory bowel disease that causes widespread digestive tract inflammation. (verywellhealth.com)
New research indicates that inflammation plays a causal role in the array of neurologic changes associated with Lyme disease, according to a study published in The American Journal of Pathology . (news-medical.net)
The researchers examined the role of inflammation in the nervous systems of Bb-infected animals. (news-medical.net)
11 A brain disease that is characterized by inflammation of the brain tissue occurring as a result of an underlying condition. (malacards.org)
Evidence indicates that neutrophil has promoted inflammation in several central nervous system diseases. (aging-us.com)
To identify a mechanistic pathway that may clarify the relationship between blood neutrophil count and neurological outcomes, we studied the role of NETs on microglia, which is the fundamental effector cells for inflammation response in the central nervous system [ 26 , 27 ]. (aging-us.com)
AA amyloidosis is another form of acquired systemic disease that results from high levels of serum AA protein, an acute phase reactant associated with chronic inflammation. (medscape.com)
Among its many beneficial health effects CBD has been shown to reduce pain and inflammation, alleviate anxiety, protect the nervous system, and prevent seizures[2-4]. (siciley.com)

however, patients with coexisting diseases, such as inflammatory bowel disease (IBD), have dietary restrictions. (medscape.com)

Basic Anatomy of the Balance System. (cdc.gov)

Intensity and quality of pain were recorded by Douleur Neuropathique en 4 questionnaire and Neuropathic Pain Symptom Inventory. (biomedcentral.com)
As with all valvular diseases, exertional dyspnea is the most common presenting symptom (80% of patients with mitral stenosis). (mhmedical.com)
Vertigo is described as a symptom, it is not a disease. (medicalsymptomsguide.com)

It affects the eyes and the skin as well as the upper respiratory system, and is able to penetrate the lungs during mouth breathing as opposed to nose breathing. (cdc.gov)
Chronic inflammatory demyelinating polyradiculoneuropathy is a rare and chronic autoimmune disease that affects the peripheral nervous system. (takeda.com)

6) 'Some aspects of the mechanism of action of atmospheric pollutants (acetone, benzene, ammonia, formaldehyde, and ozone) on the central nervous system were studied by using methods of functional electroencephalography (analysis of the readjustment reaction to a rhythmic light stimulus, evoked potentials of the cerebral cortex, and determination of the photometrazol thresholds). (harvoa.org)

Systemic emboli may occur and result in myocardial, kidney, central nervous system, or peripheral infarction. (mhmedical.com)

Departments of neurooncology, acute injury of the central and peripheral nervous system, neuro-vascular pathology, restorative neurosurgery and pediatric neurosurgery were created. (kiev.ua)
While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. (dealpain.net)

Centers for Disease Control and Prevention. (cdc.gov)
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)

Neurological diseases range from Alzheimer's and other dementias to stroke and brain cancer . (labiotech.eu)
Diabetes can also increase the risk of heart disease, stroke, kidney disease, vision problems, and nervous system issues. (nomonausea.com)

Disease of the brain. (studystack.com)
Transplantation experiments have demonstrated the potential of mouse ES derived neural cells to participate in brain development and to correct various deficits in animal model systems. (justia.com)
Many neurological diseases affect multiple regions of the brain and many cell types. (labiotech.eu)
CBD acts on your brain and body through a network of receptors called the endocannabinoid system (ECS). (siciley.com)
Cannabinoids and their receptors throughout the brain and body form an interconnected network called the endocannabinoid system (ECS). (siciley.com)

Chemokines such as IL-8 and CCL2 are known to mediate the influx of immune cells in the central nervous system compartment during bacterial meningitis, and CXCL13 is the major determinant of B cell recruitment into the cerebrospinal fluid during neuroinflammation,' explained Dr. Philipp. (news-medical.net)

Although many studies have focused on elucidating the pathogenesis of CMT, few focuses on achieving a systematic analysis of biology to decode the underlying pathological molecular mechanisms and the mechanism of its disease remains to be elucidated. (hindawi.com)
Emphasis on fundamental knowledge of the structure, neurochemistry and molecular mechanisms of the central and peripheral nervous systems in health and disease. (iu.edu)
She also emphasizes the importance of Kaposi's contribution in recognizing SLE as a systemic disease, because that enabled the search for underlying mechanisms. (the-rheumatologist.org)
The following aspects were analyzed among the proposed mechanisms: changes in the occlusion and condylar position, increase in the vertical dimension, change of the peripheral impulse to the central nervous system, natural regression to the mean, placebo effect and individual's cognitive awareness. (bvsalud.org)

Anatomy41

Organisms10

Diseases33

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Psychiatry and Psychology1

Phenomena and Processes18

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Named Groups1

Health Care4

Unsuccessful surgical treatment of hip dislocation in congenital sensory neuropathy with anhidrosis. A case report. (1/1736)

Phase II study of cisplatin and vinorelbine as first-line chemotherapy in patients with carcinoma of the uterine cervix. (2/1736)

Clinicopathological features of Churg-Strauss syndrome-associated neuropathy. (3/1736)

Neurological complications of neurofibromatosis type 1 in adulthood. (4/1736)

Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data. (5/1736)

Ten- to 15-year outcome of surgery for lumbar disc herniation: radiographic instability and clinical findings. (6/1736)

Successful treatment of IgM paraproteinaemic neuropathy with fludarabine. (7/1736)

Vasculitic polyradiculopathy in systemic lupus erythematosus. (8/1736)

Central Nervous System Diseases

Peripheral Nervous System Diseases

Peripheral Nervous System

Nervous System Diseases

Central Nervous System Viral Diseases

Meningoencephalitis

Central Nervous System Infections

Central Nervous System

Brain

Subacute Sclerosing Panencephalitis

AIDS Dementia Complex

Brain Diseases

Demyelinating Diseases

Maus Elberfeld virus

Peripheral Nerves

Cerebrospinal Fluid

Meninges

Enterovirus Infections

Nervous System

Neurons

Astrocytes

Schwann Cells

Sciatic Nerve

Disease Models, Animal

Myelin Sheath

Magnetic Resonance Imaging

Cells, Cultured

Axons

Peripheral Nervous System Neoplasms

Ganglia, Spinal

Autonomic Nervous System Diseases

Lamin Type A

Enteric Nervous System

Neural Crest

Immunohistochemistry

Spinal Cord

Nerve Regeneration

Digestive System Diseases

Nerve Tissue Proteins

Neuroglia

Nervous System Physiological Phenomena

Myelin P0 Protein

Mutation

In Situ Hybridization

Peripheral Nerve Injuries

Time Factors

Neural Conduction

Gene Expression Regulation, Developmental

Charcot-Marie-Tooth Disease

Myelin Proteins

Molecular Sequence Data

Cause of Death

Wallerian Degeneration

Neuritis, Autoimmune, Experimental

Autonomic Nervous System

Ranvier's Nodes

Autopsy

Central Nervous System Neoplasms

SOXE Transcription Factors

Sympathetic Nervous System

Trauma, Nervous System

Heart Conduction System

Nervous System Neoplasms

Neurons, Afferent

Sense Organs

Drosophila

Cell Differentiation

Drosophila Proteins

Polyneuropathies

Neurofilament Proteins

RNA, Messenger

Ganglia, Sympathetic

Nerve Growth Factors

Immune System Diseases

Cranial Nerves

Sensory Receptor Cells

Sural Nerve

Mice, Inbred C57BL

Amino Acid Sequence

Endocrine System Diseases