AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Central Nervous System DiseasesPeripheral Nervous System DiseasesPeripheral Nervous SystemNervous System DiseasesCentral Nervous System Viral DiseasesMeningoencephalitisCentral Nervous System InfectionsCentral Nervous SystemBrainSubacute Sclerosing PanencephalitisAIDS Dementia ComplexBrain DiseasesDemyelinating DiseasesMaus Elberfeld virusPeripheral NervesCerebrospinal FluidMeningesEnterovirus InfectionsNervous SystemNeuronsAstrocytesSchwann CellsSciatic NerveDisease Models, AnimalMyelin SheathMagnetic Resonance ImagingCells, CulturedAxonsPeripheral Nervous System NeoplasmsGanglia, SpinalAutonomic Nervous System DiseasesLamin Type AEnteric Nervous SystemNeural CrestImmunohistochemistrySpinal CordNerve RegenerationDigestive System DiseasesNerve Tissue ProteinsNeurogliaNervous System Physiological PhenomenaMyelin P0 ProteinMutationIn Situ HybridizationPeripheral Nerve InjuriesTime FactorsNeural ConductionGene Expression Regulation, DevelopmentalCharcot-Marie-Tooth DiseaseMyelin ProteinsMolecular Sequence DataCause of DeathWallerian DegenerationNeuritis, Autoimmune, ExperimentalAutonomic Nervous SystemRanvier's NodesAutopsyCentral Nervous System NeoplasmsSOXE Transcription FactorsSympathetic Nervous SystemTrauma, Nervous SystemHeart Conduction SystemNervous System NeoplasmsNeurons, AfferentSense OrgansDrosophilaCell DifferentiationDrosophila ProteinsPolyneuropathiesNeurofilament ProteinsRNA, MessengerGanglia, SympatheticNerve Growth FactorsImmune System DiseasesCranial NervesSensory Receptor CellsSural NerveMice, Inbred C57BLAmino Acid SequenceEndocrine System DiseasesMice, TransgenicMotor NeuronsMice, KnockoutBase SequenceChick EmbryoEmbryo, NonmammalianPeripheral Nervous System AgentsPeripheral Vascular DiseasesRats, Sprague-DawleyGangliaSignal TransductionGene ExpressionOligodendrogliaRisk FactorsEarly Growth Response Protein 2PhenotypeNeuropeptidesInfant, NewbornTranscription FactorsMice, Neurologic MutantsNeuritesGanglia, SensoryNeurofibromatosesCell Adhesion Molecules, NeuronalCell MovementGanglioside GalactosyltransferaseNerve DegenerationBrain ChemistryDrosophila melanogasterGene Expression RegulationLeukocytes, MononuclearSciatic NeuropathyMyelin Basic ProteinCohort StudiesNeuritisTrigeminal GanglionGenes, InsectCentral Nervous System HelminthiasisTibial NerveRetrospective StudiesOrgan SpecificityZebrafishMembrane ProteinsNerve CrushBrain StemLeukodystrophy, Globoid CellNerve TissueAnimals, NewbornDiabetic NeuropathiesBasic Helix-Loop-Helix Transcription FactorsFluorescent Antibody TechniqueTissue Distribution
Central Nervous System Diseases: Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.Peripheral Nervous System Diseases: Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.Peripheral Nervous System: The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.Central Nervous System Viral Diseases: Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.Meningoencephalitis: An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.Central Nervous System Infections: Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.Central Nervous System: The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Subacute Sclerosing Panencephalitis: A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)AIDS Dementia Complex: A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.Maus Elberfeld virus: A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, usually causing an inapparent intestinal infection in mice. A small number of mice may show signs of flaccid paralysis.Peripheral Nerves: The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.Cerebrospinal Fluid: A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.Meninges: The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.Enterovirus InfectionsNervous System: The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Astrocytes: A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.Schwann Cells: Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.Sciatic Nerve: A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Myelin Sheath: The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Axons: Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.Peripheral Nervous System Neoplasms: Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)Ganglia, Spinal: Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.Autonomic Nervous System Diseases: Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.Lamin Type A: A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during mitosis.Enteric Nervous System: Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)Neural Crest: The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Spinal Cord: A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.Nerve Regeneration: Renewal or physiological repair of damaged nerve tissue.Digestive System Diseases: Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).Nerve Tissue ProteinsNeuroglia: The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.Nervous System Physiological Phenomena: Characteristic properties and processes of the NERVOUS SYSTEM as a whole or with reference to the peripheral or the CENTRAL NERVOUS SYSTEM.Myelin P0 Protein: A protein that accounts for more than half of the peripheral nervous system myelin protein. The extracellular domain of this protein is believed to engage in adhesive interactions and thus hold the myelin membrane compact. It can behave as a homophilic adhesion molecule through interactions with its extracellular domains. (From J Cell Biol 1994;126(4):1089-97)Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Peripheral Nerve Injuries: Injuries to the PERIPHERAL NERVES.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Neural Conduction: The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Charcot-Marie-Tooth Disease: A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)Myelin Proteins: MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Cause of Death: Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.Wallerian Degeneration: Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.Neuritis, Autoimmune, Experimental: An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)Autonomic Nervous System: The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.Ranvier's Nodes: Regularly spaced gaps in the myelin sheaths of peripheral axons. Ranvier's nodes allow saltatory conduction, that is, jumping of impulses from node to node, which is faster and more energetically favorable than continuous conduction.Autopsy: Postmortem examination of the body.Central Nervous System Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.SOXE Transcription Factors: A subclass of closely-related SOX transcription factors. Members of this subfamily have been implicated in regulating the differentiation of OLIGODENDROCYTES during neural crest formation and in CHONDROGENESIS.Sympathetic Nervous System: The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.Trauma, Nervous System: Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures.Heart Conduction System: An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.Nervous System Neoplasms: Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.Neurons, Afferent: Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.Sense Organs: Specialized organs adapted for the reception of stimuli by the NERVOUS SYSTEM.Drosophila: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Drosophila Proteins: Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.Polyneuropathies: Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.Neurofilament Proteins: Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Ganglia, Sympathetic: Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.Nerve Growth Factors: Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.Immune System Diseases: Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.Cranial Nerves: Twelve pairs of nerves that carry general afferent, visceral afferent, special afferent, somatic efferent, and autonomic efferent fibers.Sensory Receptor Cells: Specialized afferent neurons capable of transducing sensory stimuli into NERVE IMPULSES to be transmitted to the CENTRAL NERVOUS SYSTEM. Sometimes sensory receptors for external stimuli are called exteroceptors; for internal stimuli are called interoceptors and proprioceptors.Sural Nerve: A branch of the tibial nerve which supplies sensory innervation to parts of the lower leg and foot.Mice, Inbred C57BLAmino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Endocrine System Diseases: Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Motor Neurons: Neurons which activate MUSCLE CELLS.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Chick Embryo: The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.Embryo, Nonmammalian: The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.Peripheral Nervous System Agents: Drugs that act principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system. (From Smith and Reynard, Textbook of Pharmacology, 1991, p75)Peripheral Vascular Diseases: Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Ganglia: Clusters of multipolar neurons surrounded by a capsule of loosely organized CONNECTIVE TISSUE located outside the CENTRAL NERVOUS SYSTEM.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Oligodendroglia: A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Early Growth Response Protein 2: An early growth response transcription factor that controls the formation of the MYELIN SHEATH around peripheral AXONS by SCHWANN CELLS. Mutations in EGR2 transcription factor have been associated with HEREDITARY MOTOR AND SENSORY NEUROPATHIES such as CHARCOT-MARIE-TOOTH DISEASE.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Neuropeptides: Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.Infant, Newborn: An infant during the first month after birth.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Mice, Neurologic Mutants: Mice which carry mutant genes for neurologic defects or abnormalities.Neurites: In tissue culture, hairlike projections of neurons stimulated by growth factors and other molecules. These projections may go on to form a branched tree of dendrites or a single axon or they may be reabsorbed at a later stage of development. "Neurite" may refer to any filamentous or pointed outgrowth of an embryonal or tissue-culture neural cell.Ganglia, Sensory: Clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons. Sensory ganglia may also have intrinsic interneurons and non-neuronal supporting cells.Neurofibromatoses: A group of disorders characterized by an autosomal dominant pattern of inheritance with high rates of spontaneous mutation and multiple neurofibromas or neurilemmomas. NEUROFIBROMATOSIS 1 (generalized neurofibromatosis) accounts for approximately 95% of cases, although multiple additional subtypes (e.g., NEUROFIBROMATOSIS 2, neurofibromatosis 3, etc.) have been described. (From Neurochirurgie 1998 Nov;44(4):267-72)Cell Adhesion Molecules, Neuronal: Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Ganglioside Galactosyltransferase: Catalyzes the final step in the galactocerebroside biosynthesis pathway.Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.Brain Chemistry: Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.Drosophila melanogaster: A species of fruit fly much used in genetics because of the large size of its chromosomes.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Leukocytes, Mononuclear: Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.Sciatic Neuropathy: Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)Myelin Basic Protein: An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Neuritis: A general term indicating inflammation of a peripheral or cranial nerve. Clinical manifestation may include PAIN; PARESTHESIAS; PARESIS; or HYPESTHESIA.Trigeminal Ganglion: The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.Genes, Insect: The functional hereditary units of INSECTS.Central Nervous System Helminthiasis: Infections of the BRAIN; SPINAL CORD; or MENINGES caused by HELMINTHS (parasitic worms).Tibial Nerve: The medial terminal branch of the sciatic nerve. The tibial nerve fibers originate in lumbar and sacral spinal segments (L4 to S2). They supply motor and sensory innervation to parts of the calf and foot.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Organ Specificity: Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.Zebrafish: An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Nerve Crush: Treatment of muscles and nerves under pressure as a result of crush injuries.Brain Stem: The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.Leukodystrophy, Globoid Cell: An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.Nerve Tissue: Differentiated tissue of the central nervous system composed of NERVE CELLS, fibers, DENDRITES, and specialized supporting cells.Animals, Newborn: Refers to animals in the period of time just after birth.Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)Basic Helix-Loop-Helix Transcription Factors: A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

Unsuccessful surgical treatment of hip dislocation in congenital sensory neuropathy with anhidrosis. A case report. (1/1736)

A six-year-old girl with congenital sensory neuropathy with anhidrosis (CSNA) presented with bilateral hip dysplasia and subluxation on the right side. Conservative treatment of the hips by closed reduction and a plaster cast was unsuccessful. When aged seven years the patient had an intertrochanteric varus rotation osteotomy on the right side, but subluxation was again evident after five months. A Salter-type pelvic osteotomy was carried out followed by immobilisation, but one year later subluxation was present in the right hip and dislocation in the left. At the age of nine years, the right femoral head resembled a Charcot joint, although walking ability was preserved. In patients with CSNA, surgery may not always be advisable.  (+info)

Phase II study of cisplatin and vinorelbine as first-line chemotherapy in patients with carcinoma of the uterine cervix. (2/1736)

PURPOSE: To evaluate the activity and toxicity of the combination of cisplatin (80 mg/m2 day 1) and vinorelbine (25 mg/m2 days 1 and 8) in patients with carcinoma of the uterine cervix that has not been previously treated with chemotherapy. PATIENTS AND METHODS: Fifty patients with cervical cancer were enrolled onto this study (27 stage IB-III, 23 stage IVB-recurrent). A two-stage optimal Simon design was applied. Thirteen responders of 29 treated patients were required to proceed beyond the first stage, and 28 responders were needed overall. RESULTS: Hematologic toxicity was mild, with neutropenia being the most frequent side effect. Nonhematologic toxicity was frequent but never severe; one patient had grade 3 peripheral neurotoxicity. Objective responses were recorded for 32 patients (64%): 11 patients (22%) achieved a complete response (CR) and 21 patients (42%) achieved a partial response (PR). The response rate was 81.5% in patients with IB-III stage (25.9% CR rate) and 43.5% in patients with IVB-recurrent disease (17.4% CR rate). Responses were seen both in stage IVB patients (one CR and two PRs, for an overall rate of 37.5%) and in patients with recurrent disease (three CRs + four PRs, for an overall rate of 46.7%). CONCLUSION: The combination of cisplatin and vinorelbine is an active regimen in the treatment of patients with early-stage and advanced carcinoma of the uterine cervix. The hematologic and nonhematologic toxicity of this combination is mild.  (+info)

Clinicopathological features of Churg-Strauss syndrome-associated neuropathy. (3/1736)

We assessed the clinicopathological features of 28 patients with peripheral neuropathy associated with Churg-Strauss syndrome. Initial symptoms attributable to neuropathy were acute painful dysaesthesiae and oedema in the dysaesthetic portion of the distal limbs. Sensory and motor involvement mostly showed a pattern of mononeuritis multiplex in the initial phase, progressing into asymmetrical polyneuropathy, restricted to the limbs. Parallel loss of myelinated and unmyelinated fibres due to axonal degeneration was evident as decreased or absent amplitudes of sensory nerve action potentials and compound muscle action potentials, indicating acute massive axonal loss. Epineurial necrotizing vasculitis was seen in 54% of cases; infiltrates consisted mainly of CD8-positive suppressor/cytotoxic and CD4-positive helper T lymphocytes. Eosinophils were present in infiltrates, but in smaller numbers than lymphocytes. CD20-positive B lymphocytes were seen only occasionally. Deposits of IgG, C3d, IgE and major basic protein were scarce. The mean follow-up period was 4.2 years, with a range of 8 months to 10 years. Fatal outcome was seen only in a single patient, indicating a good survival rate. The patients who responded well to the initial corticosteroid therapy within 4 weeks regained self-controlled functional status in longterm follow-up (modified Rankin score was < or = 2), while those not responding well to the initial corticosteroid therapy led a dependent existence (P < 0.01). In addition the patients with poor functional outcomes had significantly more systemic organ damage caused by vasculitis (P < 0.05). Necrotizing vasculitis mediated by cytotoxic T cells, leading to ischaemic changes, appears to be a major cause of Churg-Strauss syndrome-associated neuropathy. The initial clinical course and the extent of systemic vasculitic lesions may influence the long-term functional prognosis.  (+info)

Neurological complications of neurofibromatosis type 1 in adulthood. (4/1736)

Neurofibromatosis type 1 (NF1) is a genetic disease with a wide range of neurological manifestations. To examine these, and to evaluate neurological morbidity in adulthood of patients with NF1, we studied a hospital-based series of 158 patients that included 138 adult patients aged >18 years and 20 children. NF1 evaluation included a multidisciplinary clinical and a clinically oriented radiological investigation. Neurological events occurring during childhood (in both children and adults of the series) and adulthood were recorded. One or several neurological manifestations have been observed in 55% of patients (adults and children) (n = 87). These included: headache (28 patients); hydrocephalus (7); epilepsy (5); lacunar stroke (1); white matter disease (1); intraspinal neurofibroma (3); facial palsy (1); radiculopathy (5); and polyneuropathy (2). Tumours included: optic pathway tumours (20); meningioma (2); cerebral glioma (3); and malignant peripheral nerve sheath tumours (6). Life-threatening complications were observed in five adults and included four malignant peripheral nerve sheath tumours and one meningioma. Pain was the leading symptom in 11 adults and was related to malignant peripheral nerve sheath tumours, complications of intraspinal neurofibromas, subcutaneous neurofibromas and peripheral nerve neurofibromas. NF1 in adults was not associated with other disabling or life-threatening neurological complications. Symptomatic optic pathway tumours, cerebral gliomas, symptomatic aqueductal stenosis and spinal compression due to intraspinal NF were observed exclusively during childhood. In this series, the predominant neurological features of adults with NF1 were chronic pain and malignant peripheral nerve sheath tumours.  (+info)

Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data. (5/1736)

In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and kidney of affected cats revealed contamination with the ionophor salinomycin. Epidemiologic and clinical data were collected from 823 cats, or about 1% of the cats at risk. In 21 affected cats, postmortem examination was performed. The affected cats had acute onset of lameness and paralysis of the hindlimbs followed by the forelimbs. Clinical and pathologic examination indicated a distal polyneuropathy involving both the sensory and motor nerves.  (+info)

Ten- to 15-year outcome of surgery for lumbar disc herniation: radiographic instability and clinical findings. (6/1736)

The most appropriate treatment for radiculopathy associated with disc pathology is still controversial. Since 1934, surgical treatment has consisted of hemilaminectomy and removal of the herniated material. Many authors believe that these procedures may cause degenerative spondylosis and vertebral instability. Several surgical methods have been proposed, but the long-term effects are still being debated. In addition there appear to be few well-designed outcome studies on the management of this disease. In the present study, 150 patients were selected for surgery with strict criteria and all treated with the standard technique. The series was evaluated by subjective analyses (Roland questionnaire; 120 patients), objective examinations (68 patients - 56.6%) and radiographic studies including dynamic views (analyzed by the Taillard and Boxall methods) to establish the presence of vertebral instability (50 patients - 41.6%). The subjective and objective analyses showed a high rate of good results. Radiographic studies showed vertebral instability in 30 cases, but only 9 were symptomatic. Recurrences were not observed and only a few patients suffered from leg pain. The standard procedure for lumbar disc herniation showed good results at 10- and 15-year follow-up.  (+info)

Successful treatment of IgM paraproteinaemic neuropathy with fludarabine. (7/1736)

OBJECTIVES: To evaluate the response of four patients with IgM paraproteinaemic neuropathy to a novel therapy-pulsed intravenous fludarabine. BACKGROUND: The peripheral neuropathy associated with IgM paraproteinaemia usually runs a chronic, slowly progressive course which may eventually cause severe disability. Treatment with conventional immunosuppressive regimens has been unsatisfactory. Fludarabine is a novel purine analogue which has recently been shown to be effective in low grade lymphoid malignancies. METHODS: Four patients were treated with IgM paraproteinaemic neuropathy with intravenous pulses of fludarabine. Two of the four patients had antibodies to MAG and characteristic widely spaced myelin on nerve biopsy and a third had characteristic widely spaced myelin only. The fourth had an endoneurial lymphocytic infiltrate on nerve biopsy and a diagnosis of Waldenstrom's macroglobulinaemia. RESULTS: In all cases subjective and objective clinical improvement occurred associated with a significant fall in the IgM paraprotein concentration in three cases. Neurophysiological parameters improved in the three patients examined. The treatment was well tolerated. All patients developed mild, reversible lymphopenia and 50% mild generalised myelosuppression, but there were no febrile episodes. CONCLUSION: Fludarabine should be considered as a possible treatment for patients with IgM MGUS paraproteinaemic neuropathy.  (+info)

Vasculitic polyradiculopathy in systemic lupus erythematosus. (8/1736)

A 22 year old woman with recently diagnosed systemic lupus erythematosus presented with subacute progressive areflexic paraparesis, electrophysiologically identified as a pure axonal polyradiculopathy. Sural nerve biopsy disclosed necrotising vasculitis. A striking radiological feature was marked enhancement of the cauda equina with gadolinium.  (+info)

Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American society of...Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American society of...
TY - JOUR. T1 - Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers. T2 - American society of clinical oncology clinical practice guideline. AU - Hershman, Dawn L.. AU - Lacchetti, Christina. AU - Dworkin, Robert H.. AU - Lavoie Smith, Ellen M.. AU - Bleeker, Jonathan. AU - Cavaletti, Guido. AU - Chauhan, Cynthia. AU - Gavin, Patrick. AU - Lavino, Antoinette. AU - Lustberg, Maryam B.. AU - Paice, Judith. AU - Schneider, Bryan. AU - Smith, Mary Lou. AU - Smith, Tom. AU - Terstriep, Shelby. AU - Wagner-Johnston, Nina. AU - Bak, Kate. AU - Loprinzi, Charles L.. PY - 2014/6/20. Y1 - 2014/6/20. N2 - Purpose: To provide evidence-based guidance on the optimum prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathies (CIPN) in adult cancer survivors. Methods: A systematic literature search identified relevant, randomized controlled trials (RCTs) for the treatment of CIPN. Primary outcomes included incidence and ...
Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: Taxol- and thalidomide-induced injury...Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: Taxol- and thalidomide-induced injury...
TY - JOUR. T1 - Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy. T2 - Taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF. AU - Kirchmair, Rudolf. AU - Tietz, Anne B.. AU - Panagiotou, Eleftheria. AU - Walter, Dirk H.. AU - Silver, Marcy. AU - Yoon, Young Sup. AU - Schratzberger, Peter. AU - Weber, Alberto. AU - Kusano, Kengo. AU - Weinberg, David H.. AU - Ropper, Allan H.. AU - Isner, Jeffrey M.. AU - Losordo, Douglas W.. PY - 2007/1. Y1 - 2007/1. N2 - Toxic neuropathy represents an important clinical problem in the use of the chemotherapeutic substances Taxol and thalidomide. Sensory neuropathy has a high incidence, lacks an effective treatment and is the dose-limiting factor for these drugs. The pathogenic basis of these neuropathies is unknown. We investigated the hypothesis that the experimental toxic neuropathies from Taxol and thalidomide results from destruction of vasa nervorum and can be reversed by the administration of ...
Toxics | Free Full-Text | Axonal Transport Impairment in Chemotherapy-Induced Peripheral NeuropathyToxics | Free Full-Text | Axonal Transport Impairment in Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a dose-limiting side effect of several antineoplastic drugs which significantly reduces patients quality of life. Although different molecular mechanisms have been investigated, CIPN pathobiology has not been clarified yet. It has largely been recognized that Dorsal Root Ganglia are the main targets of chemotherapy and that the longest nerves are the most damaged, together with fast axonal transport. Indeed, this bidirectional cargo-specific transport has a pivotal role in neuronal function and its impairment is involved in several neurodegenerative and neurodevelopmental diseases. Literature data demonstrate that, despite different mechanisms of action, all antineoplastic agents impair the axonal trafficking to some extent and the severity of the neuropathy correlates with the degree of damage on this bidirectional transport. In this paper, we will examine the effect of the main old and new chemotherapeutic drug categories on axonal transport, with
Chemotherapy-induced peripheral neuropathy - WikipediaChemotherapy-induced peripheral neuropathy - Wikipedia
Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, enduring, and often irreversible condition featuring pain, numbness, tingling and sensitivity to cold in the hands and feet (sometimes progressing to the arms and legs) that afflicts between 30% and 40% of patients undergoing chemotherapy. Chemotherapy drugs associated with CIPN include thalidomide, the epothilones such as ixabepilone, the vinca alkaloids vincristine and vinblastine, the taxanes paclitaxel and docetaxel, the proteasome inhibitors such as bortezomib, and the platinum-based drugs cisplatin, oxaliplatin and carboplatin. Whether CIPN arises, and to what degree, is determined by the choice of drug, duration of use, the total amount consumed and whether the patient already has peripheral neuropathy. Though the symptoms are mainly sensory - pain, tingling, numbness and temperature sensitivity - in some cases motor nerves are affected, and occasionally, also, the autonomic nervous system. CIPN often follows the first ...
Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update. |...Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update. |...
To update the ASCO guideline on the recommended prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathy (CIPN) in adult cancer survivors.An Expert Panel conducted targeted systematic literature reviews to identify new studies.The search strategy identified 257 new references, which led to a full-text review of 87 manuscripts. A total of 3 systematic reviews, 2 with meta-analyses, and 28 primary trials for prevention of CIPN in addition to 14 primary trials related to treatment of established CIPN, are included in this update.The identified data reconfirmed that no agents are recommended for the prevention of CIPN. The use of acetyl-l-carnitine for the prevention of CIPN in patients with cancer should be discouraged. Furthermore, clinicians should assess the appropriateness of dose delaying, dose reduction, substitutions, or stopping chemotherapy in patients who develop intolerable neuropathy and/or functional impairment. Duloxetine is the only agent ...
Individually tailored whole-body vibration training to reduce symptoms of chemotherapy-induced peripheral neuropathy: study...Individually tailored whole-body vibration training to reduce symptoms of chemotherapy-induced peripheral neuropathy: study...
INTRODUCTION: Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and clinically meaningful side effect of cancer treatment. CIPN is induced by neurotoxic agents, causing severe sensory and/or motor deficits, resulting in disability and poor recovery, reducing patients" quality of life and limiting medical therapy. To date, effective treatment options are lacking. Whole-body vibration (WBV) training can attenuate motor and sensory deficits. We are conducting a two-armed, multicentre, assessor-blinded, randomised controlled trial, to investigate the effects of WBV on relevant symptoms of CIPN and determine the training characteristics. METHODS AND ANALYSIS: In this ongoing study, 44 patients who have completed therapy in the past 3 months, with a neurologically confirmed CIPN are assessed before and after a 12-week intervention and follow-up. The intervention group receives WBV twice a week. Exercises are individually tailored according to the initially determined optimal ...
Chemotherapy-induced peripheral neuropathy: the end of the beginning? | Journal of Neurology, Neurosurgery & PsychiatryChemotherapy-induced peripheral neuropathy: the end of the beginning? | Journal of Neurology, Neurosurgery & Psychiatry
Rapid advances have been made in the diagnosis and treatment of neurological disease over the last two decades. Over that period, major developments have also occurred in other fields of medicine, most notably in the management of cancer. Two-thirds of all cancer patients now survive at 5-years post-diagnosis, with over 28 million cancer survivors worldwide.1 As cancer outcomes improve, there has been increased focus on the long-term quality of life in cancer survivors. Not unexpectedly, neurological complications are a prevalent and potentially disabling long-term side effect of cancer treatment. Chemotherapy-induced peripheral neuropathy (CIPN), in particular, is the dose-limiting toxicity of many chemotherapeutic agents, … ...
ASCO Releases Guideline on Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult...ASCO Releases Guideline on Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult...
ASCO has released a clinical practice guideline on prevention and treatment of chemotherapy-induced peripheral neuropathy in adult cancer patients, published in the Journal of Clinical Oncology.1. The guidelines resulted from the efforts of an expert panel, with representation from the fields of medical oncology, community oncology, nursing, pain research, genetics, neurology, pharmacology, patient representation, and guideline methodology. Charles Loprinzi, MD, of the Mayo Clinic, Rochester, Minnesota, and Dawn Hershman, MD, of Columbia University Medical Center, New York, were the panel co-chairs.. The overall incidence of the condition is estimated at close to 40% in patients treated with multiple agents, with reported rates varying according to chemotherapy regimens, duration of exposure, and assessment methods. Regimens associated with higher risk are those including platinum drugs, vinca alkaloids, bortezomib (Velcade), and taxanes.. Clinical Question. The clinical question addressed by ...
Multivitamins may reduce risk for chemotherapy-induced peripheral neuropathyMultivitamins may reduce risk for chemotherapy-induced peripheral neuropathy
Multivitamin supplements may reduce incidence of chemotherapy-induced peripheral neuropathy among women undergoing treatment with paclitaxel for breast cancer, according to results of a study led by researchers at Roswell Park Comprehensive Cancer Center.“Our study showed that use of multivitamin supplements, but not specific vitamins, was associated with less neurotoxicity,”
A new approach to prevent the chemotherapy-induced peripheral neuropathy<...A new approach to prevent the chemotherapy-induced peripheral neuropathy<...
TY - JOUR. T1 - A new approach to prevent the chemotherapy-induced peripheral neuropathy. AU - Kawashiri, Takehiro. PY - 2019/1/1. Y1 - 2019/1/1. UR - http://www.scopus.com/inward/record.url?scp=85064722410&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85064722410&partnerID=8YFLogxK. U2 - 10.1254/fpj.153.200. DO - 10.1254/fpj.153.200. M3 - Comment/debate. C2 - 30971662. AN - SCOPUS:85064722410. VL - 153. JO - Folia Pharmacologica Japonica. JF - Folia Pharmacologica Japonica. SN - 0015-5691. IS - 4. ER - ...
The Purpose of This Study is to Determine if Tetrodotoxin (TTX) is Effective in the Treatment of Pain Resulting From...The Purpose of This Study is to Determine if Tetrodotoxin (TTX) is Effective in the Treatment of Pain Resulting From...
Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting side effect of many chemotherapeutic agents including vincristine, paclitaxel, cisplatin, oxaliplatin, bortezomib and ixabepilone. Chemotherapy-induced peripheral neuropathy commonly occurs in greater than 40% of patients. To improve the peripheral neuropathy, the chemotherapy dosing is often either decreased or discontinued potentially affecting tumor responsiveness, prognosis, and survival.. There is an unmet medical need for treatment of cancer patients with chemotherapy induced neuropathic pain (CINP) and the proposed study will investigate the efficacy and safety of multiple dose levels of tetrodotoxin (TTX) versus placebo in moderate to severe neuropathic pain caused by chemotherapy. ...
A New Diagnostic Method to Assess Paclitaxel-Induced Peripheral NeuropathyA New Diagnostic Method to Assess Paclitaxel-Induced Peripheral Neuropathy
Condition: Chemotherapy-induced Peripheral Neuropathy Intervention: Sponsors: Carsten Dahl Mørch; Aalborg University Hospital Not yet recruiting...
Chemotherapy-Induced Peripheral Neuropathy (CIPN) Report 2018 - Market Insights, Epidemiology and Market Forecast, 2016-2027Chemotherapy-Induced Peripheral Neuropathy (CIPN) Report 2018 - Market Insights, Epidemiology and Market Forecast, 2016-2027
Dublin, Dec. 05, 2018 (GLOBE NEWSWIRE) -- The Chemotherapy-Induced Peripheral Neuropathy (CIPN) - Market Insights, Epidemiology and Market Forecast...
Cryotherapy May Prevent Symptoms of Chemotherapy-Induced Peripheral NeuropathyCryotherapy May Prevent Symptoms of Chemotherapy-Induced Peripheral Neuropathy
A recent study evaluated the efficacy of cryotherapy for chemo-induced peripheral neuropathy; study participants wore frozen gloves and socks on the dominant side for 90 minutes, including the entire duration of drug infusion.
Calendar - USF Nursing NewsCalendar - USF Nursing News
The USF College of Nursing is pleased to host Ellen M. Lavoie Smith, PhD, APRN, AOCN®, FAAN, who will present "Bedside to Bench to Bedside: Managing Painful Chemotherapy-Induced Peripheral Neuropathy" at noon on Tuesday, March 5, in MDN 2005. Dr. Smith is an associate professor and director of the PhD program at the University of Michigan School of Nursing. Her program of research is focused on improving the assessment and treatment of chronic, cancer-related neuropathic pain, with a specialty focus in painful chemotherapy-induced peripheral neuropathy. She has received independent research funding from the National Institutes of Health, the Oncology Nursing Society, the American Cancer Society, Dartmouth, and the University of Michigan. Dr. Smith conducted a cross-sectional study evaluating the clinimetric properties of peripheral neuropathy and neuropathic pain measurement approaches. She also completed an Oncology Nursing Society-funded study focused on utilizing quality improvement ...
Vincristine - WikipediaVincristine - Wikipedia
The main side effects of vincristine are chemotherapy-induced peripheral neuropathy, hyponatremia, constipation, and hair loss. Chemotherapy-induced peripheral neuropathy can be severe, and may be a reason to reduce or avoid using vincristine. The symptoms of this are progressive and enduring tingling numbness, pain and hypersensitivity to cold, beginning in the hands and feet and sometimes affecting the arms and legs.[9] One of the first symptoms of peripheral neuropathy is foot drop: A person with a family history of foot drop and/or Charcot-Marie-Tooth disease (CMT) should avoid the taking of vincristine.[10]. Accidental injection of vinca alkaloids into the spinal canal (intrathecal administration) is highly dangerous, with a mortality rate approaching 100 percent. The medical literature documents cases of ascending paralysis due to massive encephalopathy and spinal nerve demyelination, accompanied by intractable pain, almost uniformly leading to death. Several patients have survived after ...
Chemotherapy-induced peripheral neuropathy | Peter MacCallum Cancer CentreChemotherapy-induced peripheral neuropathy | Peter MacCallum Cancer Centre
Chemotherapy can impact or damage the bodys peripheral nerves. Peripheral nerves carry sensations (or neurological messages) to and from the brain and spine, to control feeling and movement in different parts of the body including arms, legs, hands and feet. They also control the bowel and bladder. Damage to peripheral nerves that is caused by chemotherapy is called
Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia |...Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia |...
Paclitaxel is an effective chemotherapeutic agent widely used for the treatment of solid tumors. The major dose-limiting toxicity of paclitaxel is peripheral neuropathy. The mechanisms underlying the development and maintenance of paclitaxel-induced peripheral neuropathy are still unclear, and there are no currently established effective treatments. Accumulating evidence in models of neuropathic pain in which peripheral nerves are lesioned has implicated spinal microglia and chemokines in pain hypersensitivity, but little is know about their roles in chemotherapy-induced peripheral neuropathy. In the present study, we investigated the role of CC-chemokine ligand 3 (CCL3) in the spinal cord in the development and maintenance of mechanical allodynia using a rat model of paclitaxel-induced neuropathy. Repeated intravenous administration of paclitaxel induced a marked decrease in paw withdrawal threshold in response to mechanical stimulation (mechanical allodynia). In these rats, the number of microglia in
Chemotherapy-Induced Peripheral Neuropathy Survey - Full Text View - ClinicalTrials.govChemotherapy-Induced Peripheral Neuropathy Survey - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
PQ9) A Novel Mechanism of Paclitaxel-Induced Peripheral Neuropathy and Potential Treatment - UTMB Health Research Expert...PQ9) A Novel Mechanism of Paclitaxel-Induced Peripheral Neuropathy and Potential Treatment - UTMB Health Research Expert...
Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2020 Elsevier B.V "We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies. Log in to Pure. ...
GS-1101 - BET-bromodomain inhibition researchGS-1101 - BET-bromodomain inhibition research
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and incapacitating complications of tumor treatment. outcomes the group of studies revealed essential lessons which have up to date subsequent function. Some examples of the include the usage of patient-reported indicator metrics the eradication of traditional-yet unsubstantiated-practice techniques as well as the breakthrough of molecular hereditary predictors of neuropathy. Current inquiry has been guided with the outcomes from these large-scale studies and therefore stands better potential for identifying long lasting solutions because of this treatment-limiting toxicity. = 0.003). The magnitude of the power from duloxetine was humble and were even more prominent with neuropathy due to oxaliplatin in comparison to paclitaxel within a subset evaluation. There is a considerably higher occurrence of CTCAE quality 2 or better exhaustion in the duloxetine arm but in any other case the medicine was well-tolerated. Organic ...
Exploring the efficacy of an electronic symptom assessment and self-care intervention to preserve physical function in...Exploring the efficacy of an electronic symptom assessment and self-care intervention to preserve physical function in...
Impaired physical function due to chemotherapy-induced peripheral neuropathy (CIPN) symptoms may lead to diminished quality of life. However, even with the knowledge of the effects of CIPN on physical function, clinicians infrequently assess and manage CIPN. Interventions that prioritize the early identification of CIPN to provide prompt treatment may reduce the impact of CIPN on physical function. The purpose of this paper is to compare self-reported physical function in individuals receiving neurotoxic chemotherapy between Electronic Symptom Assessment-Cancer (ESRA-C) intervention group (e.g., opportunity for symptom screening, self-care recommendations, communication coaching, and symptom tracking) and control group participants (i.e., electronic assessment alone). Secondary outcomes include pain intensity, sensory/motor CIPN, depression, fatigue, and insomnia. The data used in this paper are a subset of a randomized controlled trial that examined the impact of the ESRA-C intervention on symptom
JAIRO | 検索結果一覧JAIRO | 検索結果一覧
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting and disabling side effect of taxane anticancer agents. We prospectively evaluated the efficacy of cryotherapy for CIPN prevention. Methods: Breast cancer patients treated weekly with paclitaxel (80 mg/m2 for one hour) wore frozen gloves and socks on the dominant side for 90 minutes, including the entire duration of drug infusion. Symptoms on the treated sides were compared with those on the untreated (nondominant) sides. The primary end point was CIPN incidence assessed by changes in tactile sensitivity from pretreatment baseline in a monofilament test at a cumulative dose of 960 mg/m2. We also assessed thermosensory deficits, subjective symptoms (Patient Neuropathy Questionnaire [PNQ]), manipulative dexterity, and the time to events and hazard ratio by PNQ. All statistical tests were two-sided. Results: Among the 40 patients, four did not reach the cumulative dose (due to the occurrence of pneumonia, severe ...
The preventive effect of sensorimotor- and vibration exercises on the onset of Oxaliplatin- or vinca-alkaloid induced...The preventive effect of sensorimotor- and vibration exercises on the onset of Oxaliplatin- or vinca-alkaloid induced...
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and clinically relevant side effect of chemotherapy. Approximately 50% of all leukemia, lymphoma, colorectal- and breast cancer patients are affected. CIPN is induced by neurotoxic chemotherapeutic agents and can manifest with sensory and/or motor deficits. It is associated with significant disability and poor recovery. Common symptoms include pain, altered sensation, reduced or absent reflexes, muscle weakness, reduced balance control and insecure gait. These symptoms not only affect activities of daily living, subsequently reducing patients" quality of life, they have far more become a decisive limiting factor for medical therapy, causing treatment delays, dose reductions, or even discontinuation of therapy, which can affect the outcome and compromise survival. To date, CIPN cannot be prevented and its occurrence presents a diagnostic dilemma since approved and effective treatment options are lacking. Promising results ...
For Pain Relief - Botanical ChemistFor Pain Relief - Botanical Chemist
PEA is a fatty acid amide made in the body. It performs a variety of biological functions related to chronic and neuropathic pain and inflammation. These include diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, neuropathic pain, osteoarthritis, low back pain, chronic pelvic pain, post-herpetic neuralgia and neuropathic pain in stroke and MS. To date 20 clinical trials and nearly 2000 patients have been treated with PEA with positive results. Worldwide more than 800,000 patients have been treated with PEA. There has been no reported side-effects or medication interactions.. DIRECTIONS. Take 1 capsule twice a day, then 2 capsules twice a day after a few weeks. Can take up to 4 capsules twice day. Does not need to be taken with food and there is very little interaction with other medications. PEA capsules may be taken with a multi-B vitamin which is beneficial for nerve health, or Turmeric to decrease inflammation. Magnesium Glycinate 200mg capsules are also ...
From the Editor | Gotoper.comFrom the Editor | Gotoper.com
Another feature review covers the difficult-to-manage syndrome of chemotherapy-induced peripheral neuropathy (CIPN), which is poorly understood physiologically and is clinically manifested in variable fashion in terms of onset and chronicity. Drs Trivedi, Hershman, and Crew provide a very helpful overview on the physiology and clinical spectrum of CIPN, with strategies on surveillance and grading-an approach that should become standard practice. The difficulty in managing CIPN is highlighted, with a review of approaches with demonstrated benefit, but an acknowledgment that responses are variable and far from adequate, highlighting the need for more research and awareness of this common treatment side effect ...
Assessment and Treatment of Chemotherapy induced peripheral | EmbodiaAssessment and Treatment of Chemotherapy induced peripheral | Embodia
In this online course, the Canadian Physiotherapy Association is assessing Chemotherapy-Induced Peripheral Neuropathy in the pediatric population.
Breast Cancer | Cancer Network | The Oncology JournalBreast Cancer | Cancer Network | The Oncology Journal
Women who take multivitamin supplements before their breast cancer diagnosis and during chemotherapy appear to be less likely to develop the debilitating, often long-lasting symptoms of chemotherapy-induced peripheral neuropathy. Image © NIKITA TV / Shutterstock.com. ...
Toby C. Campbell, MDToby C. Campbell, MD
... is a member of the University of Wisconsin Carbone Cancer Center as an associate professor of medicine within the hematology-oncology section of the UW School of Medicine and Public Health as well as chief of the Palliative Care program and program director of the Palliative Care fellowship training program. Dr. Campbell received his medical degree from the University of Virginia and completed his internal medicine residency at the University of Wisconsin Hospital and Clinics. He recently completed fellowships in medical oncology and palliative medicine at Northwestern University.. Dr. Campbells clinical practice interests are in Lung Cancer, symptom management, communication and Palliative Care. His clinical research interests are in lung cancer therapeutics, chemotherapy-induced peripheral neuropathy, symptom management, and interdisciplinary medical teams. He is a member of the American Society of Clinical Oncology, American Association of Hospice and Palliative Medicine ...
Laser acupuncture attenuates oxaliplatin-induced peripheral neuropathy in patients with gastrointestinal cancer: a pilot...Laser acupuncture attenuates oxaliplatin-induced peripheral neuropathy in patients with gastrointestinal cancer: a pilot...
Methods 17 gastrointestinal cancer survivors (14 colorectal and 3 gastric cancers), who had been treated with oxaliplatin-based chemotherapies, were recruited. Low-level laser stimulation (50 mW) bilaterally at PC6, PC7, PC8, P9, LU11, SP6, KI3, BL60, KI1, and KI2 was administered for 20 min/point for 12 sessions over 4 weeks. The pain quality assessment scale (PQAS), chemotherapy-induced neurotoxicity questionnaire (CINQ), oxaliplatin-specific neurotoxicity scale (OSNS), quantitative touch-detection threshold (using von Frey filaments), and cold-triggered pain withdrawal latency (using the cold-water immersion test) were measured before and after completion of the 12 treatment sessions. ...
The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy...The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy...
Oxaliplatin, the third-generation platinum compound, has evolved as one of the most important therapeutic agents in colorectal cancer chemotherapy. The main limiting factor in oxaliplatin treatment is painful neuropathy that is difficult to treat. This side effect has been studied for several years, but its full mechanism is still inconclusive, and effective treatment does not exist. Data suggest that oxaliplatins initial neurotoxic effect is peripheral and oxidative stress-dependent. A spinal target is also suggested in its mechanism of action. The flavonoids rutin and quercetin have been described as cell-protecting agents because of their antioxidant, antinociceptive, and anti-inflammatory actions. We proposed a preventive effect of these agents on oxaliplatin-induced painful peripheral neuropathy based on their antioxidant properties. Oxaliplatin (1 mg/kg, i.v.) was injected in male Swiss mice, twice a week (total of nine injections). The development of sensory alterations, such as thermal and
FDA Clears Bioness New Device StimRouter to Treat Chronic Peripheral PainFDA Clears Bioness New Device StimRouter to Treat Chronic Peripheral Pain
StimRouter can change the way healthcare professionals treat chronic peripheral pain by targeting and neuromodulating the affected nerve.
Discovery Raises Prospect of New Neuropathy Treatments - MDI Biological LaboratoryDiscovery Raises Prospect of New Neuropathy Treatments - MDI Biological Laboratory
Rieger conducted her research in zebrafish exposed to paclitaxel, a chemotherapeutic agent used for ovarian, breast, lung, pancreatic and other cancers. Paclitaxel-induced peripheral neuropathy affects the majority of treated patients; however, those who are most severely affected (about 30 percent) have to terminate chemotherapy or reduce the dose because of this condition, which can impact cancer survival.. Rieger used zebrafish larvae to model peripheral neuropathy because the embryos develop rapidly and because the larval fish are translucent, making them ideal for studying the progression of nerve degeneration in live animals.. Riegers research showed that paclitaxel induces the degeneration of sensory nerve endings by damaging the outer layer of the skin, or epidermis. The epidermis is innervated by free sensory nerve endings that establish direct contact with skin cells. Her research showed that degeneration is caused by perturbations in the epidermis due to an increase in ...
AAN Annual Meeting Programs: C215 - Peripheral Neuropathy II: Update on Diabetic, Immune Axonal, and Hematologic-related...AAN Annual Meeting Programs: C215 - Peripheral Neuropathy II: Update on Diabetic, Immune Axonal, and Hematologic-related...
Peripheral neuropathies are common and affect almost eight percent of the population over age 55. New diagnostic and management options make rational therapies for PN increasingly possible. The high cost of certain diagnostic tests and therapies, along with the complexities involved in choosing which tests and treatments to initiate, complicate the management of patients with PN. Faculty will provide an update on diagnosis and management of diabetic neuropathies, immune axonal neuropathies, and neuropathies associated with hematologic disorders, including ATTR amyloidosis. This program complements Peripheral Neuropathy I: Anatomical Basis and Acquired Demyelinating Neuropathies and Peripheral Neuropathy III: Genetic Neuropathies: Molecular Diagnosis and Treatment Perspectives, but covers independent topics ...
Spinifex Announces Start of Phase 2 Proof-of-Concept Trial of EMA401 in Chemotherapy-Induced Peripheral ... ( MELBOURNE...Spinifex Announces Start of Phase 2 Proof-of-Concept Trial of EMA401 in Chemotherapy-Induced Peripheral ... ( MELBOURNE...
...MELBOURNE Australia December 10 2012 /- ...Spinifex Pharmaceuticals an Australian pain drug development company...The study is an open label biomarker study being conducted at Hammersm...The primary endpoint is the change in mean spontaneous pain intensity ...,Spinifex,Announces,Start,of,Phase,2,Proof-of-Concept,Trial,of,EMA401,in,Chemotherapy-Induced,Peripheral,Neuropathy,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
Peripheral Neuropathy Symptoms, Causes, Treatment & Prognosis Patient Comments: Peripheral Neuropathy - Symptoms - Viewers...Peripheral Neuropathy Symptoms, Causes, Treatment & Prognosis Patient Comments: Peripheral Neuropathy - Symptoms - Viewers...
View messages from patients providing insights into their medical experiences with Peripheral Neuropathy - Symptoms. Share in the message dialogue to help others and address questions on symptoms, diagnosis, and treatments, from MedicineNets doctors.
All Categories - PGRN HubAll Categories - PGRN Hub
I have performed several retrospective analyses of clinical trial datasets to discover pharmacogenetic, pharmacokinetic, and pharmacometabolomic predictors of paclitaxel-induced peripheral neuropathy and am currently collecting and analyzing larger cooperative group clinical trial cohorts to validate these findings. One ongoing project that I am particularly excited is using our previously published neuropathy prediction model, which includes paclitaxel pharmacokinetics and dosing, and attempting to introduce genetics to explain residual variability in the "neuropathy sensitivity" phenotype. I also have ongoing work in the pharmacogenetics of hormonal treatment in breast cancer. I am currently leading a meta-analysis of all patient cohorts that have tamoxifen pharmacokinetic data and CYP2D6 genetic data to generate an endoxifen prediction algorithm and empirically derive estimates of the percentage activity of individual CYP2D6 alleles. I hope that this project will improve the accuracy of ...
Cipro peripheral neuropathy : Clomid taux grossesseCipro peripheral neuropathy : Clomid taux grossesse
effects of specialist paints in the community Arrested for in indien kaufen cipro dosing in obese patients effects of specialist paints in the community how to take.. Cipro 1000 mg cipro turismo doxycycline online no prescription. Buy cipro online no prescription. Cipro and peripheral neuropathy symptoms middot yale veterinary.On prescription and its cold symptoms not the. And you are in cipro peripheral neuropathy often been this. Acomplia is only for bupropion (Wellbutrin) decreased the.Part peripheral 1: the neuropathy,. ciprofloxacine iv anaphylaxie masseur beurer cm50 anti cellulite muscles par des procédés plus physiologiques et surtout.. online cheap What Is Cetirizine.Cetirizine Side Effects.discount. The following adverse reactions have been identified peripheral neuropathy.. and HIV-associated Peripheral Neuropathy. said dosage level is for treating peripheral. ofloxacine, ciprofloxacine, gatifloxacine.. And psvt and peripheral neuropathy modified release verapamil hydrochloride ...
Peripheral NeuropathyPeripheral Neuropathy
... is a common disorder that can be caused by other medical conditions such as diabetes, renal failure, alcoholism, adverse effects of drugs, and certain immune disorders, to name a few. Having a close relative with peripheral neuropathy caused by another condition does not affect your risk of getting peripheral neuropathy, unless of course, you have the same predisposing disease.. Some peripheral neuropathies, however, have a hereditary cause. The most common hereditary neuropathy is called Charcot-Marie-Tooth (CMT) disease. There are various forms of CMT caused by different genetic mutations. Generally speaking, CMT causes neuropathy onset at a young age, usually below the age of 20. Its onset is gradual and it slowly progresses over decades. It usually presents with weakness and muscle wasting beginning in the feet, and over time progressing more proximally to the legs, then the thighs, hands and forearms. As well as muscle weakness and wasting, the feet usually develop ...
Peripheral neuropathy symptom of ms - neuropathy moisturizing gloves and socksPeripheral neuropathy symptom of ms - neuropathy moisturizing gloves and socks
Because essential oils are highly concentrated, you only need to use a very tiny amount, which goes a long way. Ali presents healing that starts with a harmonous bowel environement that frees the immune system from the clutches of a runaway fermentative state of rotting foods and acids. In addition, we noted that these associations sensory peripheral neuropathy causes diagnosis treatment not significantly affected by the treating wound care center, whether the unit of analysis was one wound on a patient or all of their wounds, or current adjuvant therapies. it has helped my arthritis in my knees.. I check my feet daily for cuts, sores or any abnormalities.I try to wash my feet daily.I am starting to cover my feet with petroleum jelly or lotion containing lanolin.
Peripheral Nerve Disorders - Columbia NeurosurgeryPeripheral Nerve Disorders - Columbia Neurosurgery
Many of us have experienced severe burning, numbness, and tingling after hitting our "funny bone." This is caused by trauma to the ulnar nerve at the elbow. Similar discomfort may be brought on by sleeping on an arm or leg in a funny position.. The brain and spinal cord are considered the Central Nervous System. Incoming and outgoing information travel in the nerves of the arm similar to a telephone wire. These nerves are considered the Peripheral Nervous System. Information regarding the environment such as hot, cold, and the position of our pen are carried on sensory nerves. Motor nerves carry bioelectrical information to muscle, resulting in contraction and movement. The other components of this peripheral system are the neuromuscular junction where the nerve meets the muscle and the muscle itself.. Neuropathy is a disorder that prevents nerves from functioning properly. It can cause paralysis if a nerve is completely lacerated, although total paralysis is rare in people with neuropathy. ...
Inherited Gene Variation Leaves Young Leukemia Patients at Risk for Peripheral Neuropathy - The ASCO PostInherited Gene Variation Leaves Young Leukemia Patients at Risk for Peripheral Neuropathy - The ASCO Post
St. Jude Childrens Research Hospital scientists have identified the first genetic variation that is associated with an increased risk and severity of peripheral neuropathy following treatment with a widely used anticancer drug. Investigators also found evidence of how it may be possible to protect young leukemia patients from this side effect without jeopardizing cures. The findings were reported by Diouf et al in the Journal of the American Medical Association.. The study involved 321 children and adolescents whose acute lymphoblastic leukemia (ALL) treatment included between 36 and 39 doses of the drug vincristine.. Vincristine is one of the most widely used and effective agents for treatment of leukemia, lymphoma, brain, and solid tumors in children and adults. But in a significant number of children and adults, the drug causes episodes of peripheral neuropathy that can become chronic and resurface in adulthood. The symptoms, which include pain, numbness, and other changes that make walking ...
Chemotherapy Induced Peripheral Neuropathy (CIPN) | MarnieClark.comChemotherapy Induced Peripheral Neuropathy (CIPN) | MarnieClark.com
Help For Chemotherapy Induced Peripheral Neuropathy (CIPN). As a breast cancer coach, one of the things I hear all too frequently is that people who undergo chemotherapy have terrible troubles with peripheral neuropathy, termed CIPN. For some, its a real problem, with long-lasting effects on nerves that sometimes never goes away. This article is dedicated to all who are undergoing chemotherapy right now, especially Taxol, with some tips and help to minimize the damage these drugs can do to your nerves.. What Is Chemotherapy Induced Peripheral Neuropathy (CIPN)?. CIPN manifests in different ways for different people. Some complain of a burning pain in their hands and/or feet, some suffer from quite the opposite problem, numbness in hands or feet, making them feel clumsy and accident-prone. One of my subscribers recently told me she had it so bad it nearly drove her crazy - she had all the symptoms, burning AND stabbing pain, as well as numbness in spots.. CIPN is caused by the chemotherapy drugs ...
Re: Hyperexcitable peripheral nerve disorder - HealthBoards Message BoardsRe: Hyperexcitable peripheral nerve disorder - HealthBoards Message Boards
Health related message boards offering discussions of numerous health topics including allergies, cancer, diabetes, heart disease, exercise, attention deficit disorder, diet, and nutrition.
Peripheral Neuropathy Symptoms, Causes, Treatment & PrognosisPeripheral Neuropathy Symptoms, Causes, Treatment & Prognosis
Peripheral neuropathy occurs when peripheral nerves become damaged. Peripheral neuropathy causes include diabetes, cancer, shingles, alcohol, medication, and vitamin deficiency. Peripheral neuropathy treatment and prognosis depend on the cause.
AAN Annual Meeting Programs: C136 - Small Fiber Neuropathies: Sensory, Autonomic, and Both II: Focus on Sensory Nervous System ...AAN Annual Meeting Programs: C136 - Small Fiber Neuropathies: Sensory, Autonomic, and Both II: Focus on Sensory Nervous System ...
Small fiber and autonomic neuropathies are common but often unrecognized conditions that affect the peripheral, somatic, and autonomic nervous systems. Through the presentation of didactic material and cases of varying complexity, faculty will facilitate a discussion of the pathophysiology, differential diagnosis, diagnostic evaluation, and therapy of these conditions. Part I will focus more heavily on conditions that impact the autonomic nervous system; Part II will focus more heavily on conditions that impact the somatic or sensory nervous system. Both parts will discuss conditions that may impact the sensory and autonomic small fibers simultaneously. This program complements C121: Small Fiber Neuropathies: Sensory, Autonomic, and Both I: Focus on Autonomic Nervous System, but covers independent topics ...
Swineshead Medical Group - Library - Health A-ZSwineshead Medical Group - Library - Health A-Z
In many cases, someone with peripheral neuropathy may have more than one of these types at the same time.. A combination of sensory and motor neuropathy is particularly common (sensorimotor polyneuropathy).. The symptoms of the main types of peripheral neuropathy are described below.. ...
Schwann Cell Mitochondrial Metabolism Supports Long-Term Axonal Survival and Peripheral Nerve Function | Journal of NeuroscienceSchwann Cell Mitochondrial Metabolism Supports Long-Term Axonal Survival and Peripheral Nerve Function | Journal of Neuroscience
In the present study, we describe the generation and characterization of mice with disrupted mitochondrial function only in SCs. We found that the induction of SC-specific mitochondrial dysfunction did not affect the survival of these cells but resulted in a severe, progressive peripheral neuropathy characterized by extensive axonal degeneration. SC mitochondrial dysfunction, therefore, disrupts the axoglial interactions required for the long-term support of axons and is a likely contributor to the clinical impairment of patients suffering from peripheral neuropathies.. Mitochondrial dysfunction is a common cause of peripheral neuropathies. An extensive body of literature has now addressed how neuronal/axonal mitochondria may contribute to the pathology observed in these diseases (Niemann et al., 2006; Baloh, 2008). The results described above show for the first time that disrupted mitochondrial function specifically in SCs can itself also cause axonal degeneration and peripheral nerve disease. ...
EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy<...EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy<...
TY - JOUR. T1 - EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy. AU - Lauria, Giuseppe. AU - Cornblath, David. AU - Johansson, O.. AU - McArthur, Justin Charles. AU - Mellgren, S. I.. AU - Nolano, M.. AU - Rosenberg, N.. AU - Sommer, C.. PY - 2005/10. Y1 - 2005/10. N2 - Skin biopsy has become a widely used tool to investigate small calibre sensory nerves including somatic unmyelinated intraepidermal nerve fibres (IENF), dermal myelinated nerve fibres, and autonomic nerve fibres in peripheral neuropathies and other conditions. Different techniques for tissue processing and nerve fibre evaluation have been used. In March 2004, a Task Force was set up under the auspices of the European Federation of Neurological Societies (EFNS) with the aim of developing guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathies. We searched the Medline database from 1989, the year of the first publication describing the innervation of human skin using ...
Peripheral NeuropathyPeripheral Neuropathy
... is the result of damage to your peripheral nerves. Some neuropathies such as Guillain-Barre syndrome can be acute and severe, requiring urgent diagnosis and treatment.. Neurological evaluation of peripheral neuropathy starts with a history and neurological exam and often includes testing to determine the type and severity of the neuropathy as well as an evaluation for possible causes of the neuropathy. An EMG (electromyogram) and nerve conduction study may be performed to further evaluate the neuropathy. Treatments are often prescribed both for the underlying cause of the neuropathy as well as for symptoms produced by the neuropathy.. Risk Factors. ...
Guillain-Barré syndromeGuillain-Barré syndrome
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Search of: Recruiting, Not yet recruiting, Available Studies | Peripheral Nervous System Diseases - List Results -...Search of: Recruiting, Not yet recruiting, Available Studies | 'Peripheral Nervous System Diseases' - List Results -...
Peripheral Nervous System Diseases | Harvard Catalyst Profiles | Harvard CatalystPeripheral Nervous System Diseases | Harvard Catalyst Profiles | Harvard Catalyst
Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of...Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of...
Peripheral Nervous System Damage in Experimental Chronic Chagas' Disease | The American Journal of Tropical Medicine and...Peripheral Nervous System Damage in Experimental Chronic Chagas' Disease | The American Journal of Tropical Medicine and...
Peripheral Nervous System Manifestations in a Sandhoff Disease Mouse Model: Nerve Conduction, Myelin Structure, Lipid AnalysisPeripheral Nervous System Manifestations in a Sandhoff Disease Mouse Model: Nerve Conduction, Myelin Structure, Lipid Analysis
The spinal cord as organizer of disease processes: II. The peripheral autonomic nervous system | The Journal of the American...The spinal cord as organizer of disease processes: II. The peripheral autonomic nervous system | The Journal of the American...
A novel mutation of LRSAM1 in a Chinese family with Charcot‐Marie‐Tooth disease, Journal of the Peripheral Nervous System | 10...A novel mutation of LRSAM1 in a Chinese family with Charcot‐Marie‐Tooth disease, Journal of the Peripheral Nervous System | 10...
JCDR - Dementia, Peripheral nervous system diseases, Renal dialysis, StrokeJCDR - Dementia, Peripheral nervous system diseases, Renal dialysis, Stroke
Peripheral nervous system disease in Systemic Lupus Erythematosus: Results from an international, inception cohort study ...Peripheral nervous system disease in Systemic Lupus Erythematosus: Results from an international, inception cohort study ...
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Peripheral Nervous System Diseases; Peripheral Nerve Diseases; Peripheral NeuropathiesPeripheral Nervous System Diseases; Peripheral Nerve Diseases; Peripheral Neuropathies
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Cubital Tunnel - Health, Conditions and Diseases, Neurological Disorders, Peripheral Nervous System, Nerve Compression SyndromesCubital Tunnel - Health, Conditions and Diseases, Neurological Disorders, Peripheral Nervous System, Nerve Compression Syndromes
Volume 36, Issue 1 | The American Journal of Tropical Medicine and HygieneVolume 36, Issue 1 | The American Journal of Tropical Medicine and Hygiene
Compound Report CardCompound Report Card
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July 2007 - Volume 13 - Issue 4 : The NeurologistJuly 2007 - Volume 13 - Issue 4 : The Neurologist
Demyelinating disease - WikipediaDemyelinating disease - Wikipedia
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Peripheral Neuropathy | MedlinePlusPeripheral Neuropathy | MedlinePlus
APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated...APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated...
Comparing Two Different Cervical Collars for the Treatment in Patient With Cervical Radiculopathy and Radicular Pain - Full...Comparing Two Different Cervical Collars for the Treatment in Patient With Cervical Radiculopathy and Radicular Pain - Full...
The| peripheral nervous system complications of HIV infection | Libyan Journal of Infectious Diseases [The]. 2007; 1 (2): 63...The| peripheral nervous system complications of HIV infection | Libyan Journal of Infectious Diseases [The]. 2007; 1 (2): 63...
WHO HQ Library catalog › Results of search for su:{Nervous system diseases} and au:WHO Study Group on Peripheral...WHO HQ Library catalog › Results of search for 'su:{Nervous system diseases} and au:WHO Study Group on Peripheral...
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Central Nervous System DiseasesPeripheral Nervous System DiseasesPeripheral Nervous SystemNervous System DiseasesCentral Nervous System Viral DiseasesMeningoencephalitisCentral Nervous System InfectionsCentral Nervous SystemBrainSubacute Sclerosing PanencephalitisAIDS Dementia ComplexBrain DiseasesDemyelinating DiseasesMaus Elberfeld virusPeripheral NervesCerebrospinal FluidMeningesEnterovirus InfectionsNervous SystemNeuronsAstrocytesSchwann CellsSciatic NerveDisease Models, AnimalMyelin SheathMagnetic Resonance ImagingCells, CulturedAxonsPeripheral Nervous System NeoplasmsGanglia, SpinalAutonomic Nervous System DiseasesLamin Type AEnteric Nervous SystemNeural CrestImmunohistochemistrySpinal CordNerve RegenerationDigestive System DiseasesNerve Tissue ProteinsNeurogliaNervous System Physiological PhenomenaMyelin P0 ProteinMutationIn Situ HybridizationPeripheral Nerve InjuriesTime FactorsNeural ConductionGene Expression Regulation, DevelopmentalCharcot-Marie-Tooth DiseaseMyelin ProteinsMolecular Sequence DataCause of DeathWallerian DegenerationNeuritis, Autoimmune, ExperimentalAutonomic Nervous SystemRanvier's NodesAutopsyCentral Nervous System NeoplasmsSOXE Transcription FactorsSympathetic Nervous SystemTrauma, Nervous SystemHeart Conduction SystemNervous System NeoplasmsNeurons, AfferentSense OrgansDrosophilaCell DifferentiationDrosophila ProteinsPolyneuropathiesNeurofilament ProteinsRNA, MessengerGanglia, SympatheticNerve Growth FactorsImmune System DiseasesCranial NervesSensory Receptor CellsSural NerveMice, Inbred C57BLAmino Acid SequenceEndocrine System DiseasesMice, TransgenicMotor NeuronsMice, KnockoutBase SequenceChick EmbryoEmbryo, NonmammalianPeripheral Nervous System AgentsPeripheral Vascular DiseasesRats, Sprague-DawleyGangliaSignal TransductionGene ExpressionOligodendrogliaRisk FactorsEarly Growth Response Protein 2PhenotypeNeuropeptidesInfant, NewbornTranscription FactorsMice, Neurologic MutantsNeuritesGanglia, SensoryNeurofibromatosesCell Adhesion Molecules, NeuronalCell MovementGanglioside GalactosyltransferaseNerve DegenerationBrain ChemistryDrosophila melanogasterGene Expression RegulationLeukocytes, MononuclearSciatic NeuropathyMyelin Basic ProteinCohort StudiesNeuritisTrigeminal GanglionGenes, InsectCentral Nervous System HelminthiasisTibial NerveRetrospective StudiesOrgan SpecificityZebrafishMembrane ProteinsNerve CrushBrain StemLeukodystrophy, Globoid CellNerve TissueAnimals, NewbornDiabetic NeuropathiesBasic Helix-Loop-Helix Transcription FactorsFluorescent Antibody TechniqueTissue Distribution
NervesNeuropathiesDisordersSymptomsSpinalPolyneuropathyNeuropathic painDisorderSymptomaticDiabetesNeuropathyNeuropathiesAutonomicSymptomsClinicalDisorders of the nervous systemNeuronsSensoryAxonAutoimmune DiseasesEtiologyPathogenesisNeurological diseasesPatientsInvolvementCentral or peripheral2016Musculoskeletal systemMyelinNeurodegenerative diseasesEndocrineMetabolicAlzheimer'sBody'sAbstractInfectionHumansDisorderTherapeuticRheumatoidImmuneDemyelinatingAffect the nervous systemMuscleNeurologyDegenerative diseasesDigestive systemCharcot-Marie-TElectromyography
Nerves4
Neuropathies2
  • Purpose: To provide evidence-based guidance on the optimum prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathies (CIPN) in adult cancer survivors. (elsevier.com)
  • Some current research in animal models has shown that neurotrophin-3 can oppose the demyelination present in some peripheral neuropathies. (wordpress.com)
Disorders1
  • The Center can help lessen the pain associated with a variety of diseases and disorders including, but not limited to, chest and back conditions, nerve injuries, rheumatologic conditions, sports injuries and cancer. (childrens.com)
Symptoms3
Spinal1
Polyneuropathy2
Neuropathic pain1
  • A range of drugs that act on the central nervous system such as drugs originally intended as antidepressants and antiepileptic drugs have been found to be useful in managing neuropathic pain. (wordpress.com)
Disorder1
  • If your provider suspects your child may have an underlying autoimmune condition, metabolic disease or connective tissue disorder, he or she may order additional blood tests and/or refer your child to a rheumatologist, endocrinologist or geneticist. (childrens.com)
Symptomatic1
Diabetes1
  • It can be inherited or caused by injury or certain diseases like shingles, hormonal imbalance, trauma or tissue injury, or diabetes, or be caused by poor nutrition or exposure to toxins. (childrens.com)
Neuropathy31
Neuropathies4
Autonomic8
Symptoms7
Clinical9
  • Numerous proofs of concepts were made in animal models of genetic diseases and translational steps on large animals allowed phase I/II clinical trials for several severe neurodegenerative conditions. (frontiersin.org)
  • Further developments in gene therapy would allow the progression and optimization of future applications regarding vector tools, therapeutic constructs, delivery systems, design of preclinical evaluation and clinical trials. (frontiersin.org)
  • The aim of this Research Topic is to present the state of the art of gene therapy for neurological diseases from a clinical perspective, and address most key aspects representing the current focus of research of the international scientific community. (frontiersin.org)
  • Objectives In a multi‐ethnic/racial, prospective SLE inception cohort, to determine the frequency, clinical characteristics, associations and outcomes in different types of peripheral nervous system (PNS) disease. (ucl.ac.uk)
  • Infant Botulism Treatment and Prevention Program Official sites for physicians to obtain BabyBIG, an FDA approved orphant drug for treatment of infant botulism type A and B. Also provides parent support forum and medical/clinical information on the disease. (inter.rs)
  • the frequencies of the symptom both as an initial sign and as observed during the clinical course of the disease were examined. (biomedsearch.com)
  • It is therefore possible that the extent of NK T cell alteration may be a critical factor which would define the clinical and pathological features of autoimmune disease. (jimmunol.org)
  • In close collaboration with the Department of Neuroradiology (www.klinikum.uni-heidelberg.de/MR-Neurographie.116270.0.html), we aim at defining more sensitive diagnostic parameters to detect lesions to the peripheral nervous system at possibly early stages of the disease and to predict response to different therapeutic options as well as to the clinical outcome more reliably. (uni-heidelberg.de)
  • The Mount Sinai Health System is an internationally recognized leader in clinical neurology, neurology education , and neurology research . (mountsinai.org)
Disorders of the nervous system3
Neurons6
Sensory1
Axon2
Autoimmune Diseases7
Etiology1
  • Most of the large envelope-bearing viruses that figured prominently in older series of ADEM, of which measles was a particularly virulent example, no longer figure importantly in the etiology of ADEM because these diseases are prevented by vaccination. (medscape.com)
Pathogenesis1
  • Therefore, the role of the human-specific prolonged period of cortical myelination is an important evolutionary consideration in the pathogenesis of demyelinating disease. (wikipedia.org)
Neurological diseases2
Patients23
  • to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. (jcdr.net)
  • Methods Patients were evaluated annually for 19 neuropsychiatric (NP) events including seven types of PNS disease. (ucl.ac.uk)
  • Mud therapy may have therapeutic value in reducing inflammation and improving the immune status of patients with traumas of the peripheral nervous system. (greenmedinfo.com)
  • Since antibodies against peripheral nervous system (PNS) antigens may play a pathogenetic role in the mechanism of nerve damage in leprosy, sera from leprosy patients and contacts were investigated for anti-PNS antibodies by ELISA and immunoblot. (ilsl.br)
  • The main objective of this research is to optimize pain treatment with patients with occupation-conditioned diseases of the locomotor system (LMS) and the peripheral nervous system (PNS). (euroasia-science.ru)
  • The patients of this research were hospitalized in the Department of Occupational Diseases, UMHAT "Dr. Georgi Stranski"- Pleven, during the period 2014-2016. (euroasia-science.ru)
  • The aim of the study is to optimize the treatment of pain in patients with work related diseases of the bones-joints and peripheral nervous system. (euroasia-science.ru)
  • Those who have been diagnosed with complex diseases, such patients also receive high-end diagnostic examination and rehabilitation measures. (placidway.com)
  • We conducted a phase 3, open-label trial involving patients with HER2-positive early breast cancer who were found to have residual invasive disease in the breast or axilla at surgery after receiving neoadjuvant therapy containing a taxane (with or without anthracycline) and trastuzumab. (nih.gov)
  • The estimated percentage of patients who were free of invasive disease at 3 years was 88.3% in the T-DM1 group and 77.0% in the trastuzumab group. (nih.gov)
  • Distant recurrence as the first invasive-disease event occurred in 10.5% of patients in the T-DM1 group and 15.9% of those in the trastuzumab group. (nih.gov)
  • Among patients with HER2-positive early breast cancer who had residual invasive disease after completion of neoadjuvant therapy, the risk of recurrence of invasive breast cancer or death was 50% lower with adjuvant T-DM1 than with trastuzumab alone. (nih.gov)
  • There is recent evidence to indicate that patients with impaired glucose tolerance ( IGT) on OGTT, the prediabetic stage, have three times the prevalence of distal peripheral polyneuropathy than age matched controls. (bioportfolio.com)
  • In patients with such neurologic disease, especially if sudden in onset, a search for a circulatory basis in lesions of the aorta or its branches may be rewarding and crucial. (biomedsearch.com)
  • Cook treats patients with diseases affecting the central or peripheral nervous system. (courant.com)
  • Determine the change in peripheral nerve function in cancer patients during and after treatment with chemotherapy or biologic therapy. (knowcancer.com)
  • Patients undergo a 1-hour peripheral nerve function assessment, including hearing, vibratory sensation, and blood pressure testing, at baseline and then at 4, 8, and 12 weeks during treatment with chemotherapy or biologic therapy. (knowcancer.com)
  • The most common central nervous system disorder in HIV patients is the infection toxoplasmosis, followed by HIV-related brain cancer. (healthcommunities.com)
  • Cerebral toxoplasmosis, also known simply as toxoplasmosis, is the most common central nervous system infection in HIV patients. (healthcommunities.com)
  • Central nervous system lymphoma is the second most common nervous system abnormality in HIV patients. (healthcommunities.com)
  • TPD significantly attenuated TACE-mediated disease models of sepsis, rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), and reduced TNFa in synovial fluids from RA patients. (weizmann.ac.il)
  • The impairment in non-verbal reasoning, speed of information processing, problem solving, learning and sequencing observed in chronic Chagas disease patients resembles the cognitive dysfunction associated with white matter disease. (scielo.br)
  • Subsequently, we determined that serum NGF and BDNF levels were correlated with: the course of disease for patients, fasting C-peptide (FCP), 2-hour postprandial C-peptide level (2-h PCP), glycosylated hemoglobin level (HbAlc), and 24-hour urinary microalbumin excretion (24-h UME). (medscimonit.com)
Involvement3
Central or peripheral1
20161
  • The subject is 58 people hospitalized in the Department of Occupational Diseases, University Hospital - Pleven in 2014-2016. (euroasia-science.ru)
Musculoskeletal system1
Myelin5
Neurodegenerative diseases2
Endocrine2
Metabolic1
Alzheimer's1
Body's4
Abstract1
Infection1
Humans1
  • The extended period of cortical myelination in humans may allow greater opportunity for disruption in myelination, resulting in the onset of demyelinating disease. (wikipedia.org)
Disorder3
Therapeutic2
  • The efficacy of gene therapy tools such as viral vectors, serotypes and therapeutic cassettes, the delivery systems manufacturing and quality control. (frontiersin.org)
  • This report is representative of the neurological and cardiac changes described in the literature for IgG4-related disease, which may be correlated or not with the renal form and highlights the need, in some cases, of targeted therapeutic approaches. (springer.com)
Rheumatoid2
Immune15
Demyelinating7
Affect the nervous system3
Muscle3
Neurology1
Degenerative diseases1
  • the first step towards regenerating damaged or diseased tissue into a fully functional and healthy organ, the project partnership has now fully defined a series of biomaterials to be combined with specific morphogens in the first series of developmental studies targeted for specific degenerative diseases. (europa.eu)
Digestive system2
Charcot-Marie-T2
Electromyography1
  • Evoked potential is an electrical potential recorded from the nervous system following the presentation of a stimulus as detected by electroencephalography (EEG), electromyography (EMG), or other electrophysiological recording method. (wikipedia.org)