Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.
An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, usually causing an inapparent intestinal infection in mice. A small number of mice may show signs of flaccid paralysis.
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.
The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.
The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during mitosis.
Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)
The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Renewal or physiological repair of damaged nerve tissue.
Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Characteristic properties and processes of the NERVOUS SYSTEM as a whole or with reference to the peripheral or the CENTRAL NERVOUS SYSTEM.
A protein that accounts for more than half of the peripheral nervous system myelin protein. The extracellular domain of this protein is believed to engage in adhesive interactions and thus hold the myelin membrane compact. It can behave as a homophilic adhesion molecule through interactions with its extracellular domains. (From J Cell Biol 1994;126(4):1089-97)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Injuries to the PERIPHERAL NERVES.
Elements of limited time intervals, contributing to particular results or situations.
The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)
MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.
Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.
An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.
Regularly spaced gaps in the myelin sheaths of peripheral axons. Ranvier's nodes allow saltatory conduction, that is, jumping of impulses from node to node, which is faster and more energetically favorable than continuous conduction.
Postmortem examination of the body.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
A subclass of closely-related SOX transcription factors. Members of this subfamily have been implicated in regulating the differentiation of OLIGODENDROCYTES during neural crest formation and in CHONDROGENESIS.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures.
An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.
Specialized organs adapted for the reception of stimuli by the NERVOUS SYSTEM.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.
Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.
Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.
Twelve pairs of nerves that carry general afferent, visceral afferent, special afferent, somatic efferent, and autonomic efferent fibers.
Specialized afferent neurons capable of transducing sensory stimuli into NERVE IMPULSES to be transmitted to the CENTRAL NERVOUS SYSTEM. Sometimes sensory receptors for external stimuli are called exteroceptors; for internal stimuli are called interoceptors and proprioceptors.
A branch of the tibial nerve which supplies sensory innervation to parts of the lower leg and foot.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Neurons which activate MUSCLE CELLS.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.
Drugs that act principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system. (From Smith and Reynard, Textbook of Pharmacology, 1991, p75)
Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Clusters of multipolar neurons surrounded by a capsule of loosely organized CONNECTIVE TISSUE located outside the CENTRAL NERVOUS SYSTEM.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An early growth response transcription factor that controls the formation of the MYELIN SHEATH around peripheral AXONS by SCHWANN CELLS. Mutations in EGR2 transcription factor have been associated with HEREDITARY MOTOR AND SENSORY NEUROPATHIES such as CHARCOT-MARIE-TOOTH DISEASE.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.
An infant during the first month after birth.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Mice which carry mutant genes for neurologic defects or abnormalities.
In tissue culture, hairlike projections of neurons stimulated by growth factors and other molecules. These projections may go on to form a branched tree of dendrites or a single axon or they may be reabsorbed at a later stage of development. "Neurite" may refer to any filamentous or pointed outgrowth of an embryonal or tissue-culture neural cell.
Clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons. Sensory ganglia may also have intrinsic interneurons and non-neuronal supporting cells.
A group of disorders characterized by an autosomal dominant pattern of inheritance with high rates of spontaneous mutation and multiple neurofibromas or neurilemmomas. NEUROFIBROMATOSIS 1 (generalized neurofibromatosis) accounts for approximately 95% of cases, although multiple additional subtypes (e.g., NEUROFIBROMATOSIS 2, neurofibromatosis 3, etc.) have been described. (From Neurochirurgie 1998 Nov;44(4):267-72)
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Catalyzes the final step in the galactocerebroside biosynthesis pathway.
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
A species of fruit fly much used in genetics because of the large size of its chromosomes.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
A general term indicating inflammation of a peripheral or cranial nerve. Clinical manifestation may include PAIN; PARESTHESIAS; PARESIS; or HYPESTHESIA.
The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.
The functional hereditary units of INSECTS.
Infections of the BRAIN; SPINAL CORD; or MENINGES caused by HELMINTHS (parasitic worms).
The medial terminal branch of the sciatic nerve. The tibial nerve fibers originate in lumbar and sacral spinal segments (L4 to S2). They supply motor and sensory innervation to parts of the calf and foot.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Treatment of muscles and nerves under pressure as a result of crush injuries.
The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.
Differentiated tissue of the central nervous system composed of NERVE CELLS, fibers, DENDRITES, and specialized supporting cells.
Refers to animals in the period of time just after birth.
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

Unsuccessful surgical treatment of hip dislocation in congenital sensory neuropathy with anhidrosis. A case report. (1/1736)

A six-year-old girl with congenital sensory neuropathy with anhidrosis (CSNA) presented with bilateral hip dysplasia and subluxation on the right side. Conservative treatment of the hips by closed reduction and a plaster cast was unsuccessful. When aged seven years the patient had an intertrochanteric varus rotation osteotomy on the right side, but subluxation was again evident after five months. A Salter-type pelvic osteotomy was carried out followed by immobilisation, but one year later subluxation was present in the right hip and dislocation in the left. At the age of nine years, the right femoral head resembled a Charcot joint, although walking ability was preserved. In patients with CSNA, surgery may not always be advisable.  (+info)

Phase II study of cisplatin and vinorelbine as first-line chemotherapy in patients with carcinoma of the uterine cervix. (2/1736)

PURPOSE: To evaluate the activity and toxicity of the combination of cisplatin (80 mg/m2 day 1) and vinorelbine (25 mg/m2 days 1 and 8) in patients with carcinoma of the uterine cervix that has not been previously treated with chemotherapy. PATIENTS AND METHODS: Fifty patients with cervical cancer were enrolled onto this study (27 stage IB-III, 23 stage IVB-recurrent). A two-stage optimal Simon design was applied. Thirteen responders of 29 treated patients were required to proceed beyond the first stage, and 28 responders were needed overall. RESULTS: Hematologic toxicity was mild, with neutropenia being the most frequent side effect. Nonhematologic toxicity was frequent but never severe; one patient had grade 3 peripheral neurotoxicity. Objective responses were recorded for 32 patients (64%): 11 patients (22%) achieved a complete response (CR) and 21 patients (42%) achieved a partial response (PR). The response rate was 81.5% in patients with IB-III stage (25.9% CR rate) and 43.5% in patients with IVB-recurrent disease (17.4% CR rate). Responses were seen both in stage IVB patients (one CR and two PRs, for an overall rate of 37.5%) and in patients with recurrent disease (three CRs + four PRs, for an overall rate of 46.7%). CONCLUSION: The combination of cisplatin and vinorelbine is an active regimen in the treatment of patients with early-stage and advanced carcinoma of the uterine cervix. The hematologic and nonhematologic toxicity of this combination is mild.  (+info)

Clinicopathological features of Churg-Strauss syndrome-associated neuropathy. (3/1736)

We assessed the clinicopathological features of 28 patients with peripheral neuropathy associated with Churg-Strauss syndrome. Initial symptoms attributable to neuropathy were acute painful dysaesthesiae and oedema in the dysaesthetic portion of the distal limbs. Sensory and motor involvement mostly showed a pattern of mononeuritis multiplex in the initial phase, progressing into asymmetrical polyneuropathy, restricted to the limbs. Parallel loss of myelinated and unmyelinated fibres due to axonal degeneration was evident as decreased or absent amplitudes of sensory nerve action potentials and compound muscle action potentials, indicating acute massive axonal loss. Epineurial necrotizing vasculitis was seen in 54% of cases; infiltrates consisted mainly of CD8-positive suppressor/cytotoxic and CD4-positive helper T lymphocytes. Eosinophils were present in infiltrates, but in smaller numbers than lymphocytes. CD20-positive B lymphocytes were seen only occasionally. Deposits of IgG, C3d, IgE and major basic protein were scarce. The mean follow-up period was 4.2 years, with a range of 8 months to 10 years. Fatal outcome was seen only in a single patient, indicating a good survival rate. The patients who responded well to the initial corticosteroid therapy within 4 weeks regained self-controlled functional status in longterm follow-up (modified Rankin score was < or = 2), while those not responding well to the initial corticosteroid therapy led a dependent existence (P < 0.01). In addition the patients with poor functional outcomes had significantly more systemic organ damage caused by vasculitis (P < 0.05). Necrotizing vasculitis mediated by cytotoxic T cells, leading to ischaemic changes, appears to be a major cause of Churg-Strauss syndrome-associated neuropathy. The initial clinical course and the extent of systemic vasculitic lesions may influence the long-term functional prognosis.  (+info)

Neurological complications of neurofibromatosis type 1 in adulthood. (4/1736)

Neurofibromatosis type 1 (NF1) is a genetic disease with a wide range of neurological manifestations. To examine these, and to evaluate neurological morbidity in adulthood of patients with NF1, we studied a hospital-based series of 158 patients that included 138 adult patients aged >18 years and 20 children. NF1 evaluation included a multidisciplinary clinical and a clinically oriented radiological investigation. Neurological events occurring during childhood (in both children and adults of the series) and adulthood were recorded. One or several neurological manifestations have been observed in 55% of patients (adults and children) (n = 87). These included: headache (28 patients); hydrocephalus (7); epilepsy (5); lacunar stroke (1); white matter disease (1); intraspinal neurofibroma (3); facial palsy (1); radiculopathy (5); and polyneuropathy (2). Tumours included: optic pathway tumours (20); meningioma (2); cerebral glioma (3); and malignant peripheral nerve sheath tumours (6). Life-threatening complications were observed in five adults and included four malignant peripheral nerve sheath tumours and one meningioma. Pain was the leading symptom in 11 adults and was related to malignant peripheral nerve sheath tumours, complications of intraspinal neurofibromas, subcutaneous neurofibromas and peripheral nerve neurofibromas. NF1 in adults was not associated with other disabling or life-threatening neurological complications. Symptomatic optic pathway tumours, cerebral gliomas, symptomatic aqueductal stenosis and spinal compression due to intraspinal NF were observed exclusively during childhood. In this series, the predominant neurological features of adults with NF1 were chronic pain and malignant peripheral nerve sheath tumours.  (+info)

Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data. (5/1736)

In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and kidney of affected cats revealed contamination with the ionophor salinomycin. Epidemiologic and clinical data were collected from 823 cats, or about 1% of the cats at risk. In 21 affected cats, postmortem examination was performed. The affected cats had acute onset of lameness and paralysis of the hindlimbs followed by the forelimbs. Clinical and pathologic examination indicated a distal polyneuropathy involving both the sensory and motor nerves.  (+info)

Ten- to 15-year outcome of surgery for lumbar disc herniation: radiographic instability and clinical findings. (6/1736)

The most appropriate treatment for radiculopathy associated with disc pathology is still controversial. Since 1934, surgical treatment has consisted of hemilaminectomy and removal of the herniated material. Many authors believe that these procedures may cause degenerative spondylosis and vertebral instability. Several surgical methods have been proposed, but the long-term effects are still being debated. In addition there appear to be few well-designed outcome studies on the management of this disease. In the present study, 150 patients were selected for surgery with strict criteria and all treated with the standard technique. The series was evaluated by subjective analyses (Roland questionnaire; 120 patients), objective examinations (68 patients - 56.6%) and radiographic studies including dynamic views (analyzed by the Taillard and Boxall methods) to establish the presence of vertebral instability (50 patients - 41.6%). The subjective and objective analyses showed a high rate of good results. Radiographic studies showed vertebral instability in 30 cases, but only 9 were symptomatic. Recurrences were not observed and only a few patients suffered from leg pain. The standard procedure for lumbar disc herniation showed good results at 10- and 15-year follow-up.  (+info)

Successful treatment of IgM paraproteinaemic neuropathy with fludarabine. (7/1736)

OBJECTIVES: To evaluate the response of four patients with IgM paraproteinaemic neuropathy to a novel therapy-pulsed intravenous fludarabine. BACKGROUND: The peripheral neuropathy associated with IgM paraproteinaemia usually runs a chronic, slowly progressive course which may eventually cause severe disability. Treatment with conventional immunosuppressive regimens has been unsatisfactory. Fludarabine is a novel purine analogue which has recently been shown to be effective in low grade lymphoid malignancies. METHODS: Four patients were treated with IgM paraproteinaemic neuropathy with intravenous pulses of fludarabine. Two of the four patients had antibodies to MAG and characteristic widely spaced myelin on nerve biopsy and a third had characteristic widely spaced myelin only. The fourth had an endoneurial lymphocytic infiltrate on nerve biopsy and a diagnosis of Waldenstrom's macroglobulinaemia. RESULTS: In all cases subjective and objective clinical improvement occurred associated with a significant fall in the IgM paraprotein concentration in three cases. Neurophysiological parameters improved in the three patients examined. The treatment was well tolerated. All patients developed mild, reversible lymphopenia and 50% mild generalised myelosuppression, but there were no febrile episodes. CONCLUSION: Fludarabine should be considered as a possible treatment for patients with IgM MGUS paraproteinaemic neuropathy.  (+info)

Vasculitic polyradiculopathy in systemic lupus erythematosus. (8/1736)

A 22 year old woman with recently diagnosed systemic lupus erythematosus presented with subacute progressive areflexic paraparesis, electrophysiologically identified as a pure axonal polyradiculopathy. Sural nerve biopsy disclosed necrotising vasculitis. A striking radiological feature was marked enhancement of the cauda equina with gadolinium.  (+info)

TY - JOUR. T1 - Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers. T2 - American society of clinical oncology clinical practice guideline. AU - Hershman, Dawn L.. AU - Lacchetti, Christina. AU - Dworkin, Robert H.. AU - Lavoie Smith, Ellen M.. AU - Bleeker, Jonathan. AU - Cavaletti, Guido. AU - Chauhan, Cynthia. AU - Gavin, Patrick. AU - Lavino, Antoinette. AU - Lustberg, Maryam B.. AU - Paice, Judith. AU - Schneider, Bryan. AU - Smith, Mary Lou. AU - Smith, Tom. AU - Terstriep, Shelby. AU - Wagner-Johnston, Nina. AU - Bak, Kate. AU - Loprinzi, Charles L.. PY - 2014/6/20. Y1 - 2014/6/20. N2 - Purpose: To provide evidence-based guidance on the optimum prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathies (CIPN) in adult cancer survivors. Methods: A systematic literature search identified relevant, randomized controlled trials (RCTs) for the treatment of CIPN. Primary outcomes included incidence and ...
TY - JOUR. T1 - Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy. T2 - Taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF. AU - Kirchmair, Rudolf. AU - Tietz, Anne B.. AU - Panagiotou, Eleftheria. AU - Walter, Dirk H.. AU - Silver, Marcy. AU - Yoon, Young Sup. AU - Schratzberger, Peter. AU - Weber, Alberto. AU - Kusano, Kengo. AU - Weinberg, David H.. AU - Ropper, Allan H.. AU - Isner, Jeffrey M.. AU - Losordo, Douglas W.. PY - 2007/1. Y1 - 2007/1. N2 - Toxic neuropathy represents an important clinical problem in the use of the chemotherapeutic substances Taxol and thalidomide. Sensory neuropathy has a high incidence, lacks an effective treatment and is the dose-limiting factor for these drugs. The pathogenic basis of these neuropathies is unknown. We investigated the hypothesis that the experimental toxic neuropathies from Taxol and thalidomide results from destruction of vasa nervorum and can be reversed by the administration of ...
Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a dose-limiting side effect of several antineoplastic drugs which significantly reduces patients quality of life. Although different molecular mechanisms have been investigated, CIPN pathobiology has not been clarified yet. It has largely been recognized that Dorsal Root Ganglia are the main targets of chemotherapy and that the longest nerves are the most damaged, together with fast axonal transport. Indeed, this bidirectional cargo-specific transport has a pivotal role in neuronal function and its impairment is involved in several neurodegenerative and neurodevelopmental diseases. Literature data demonstrate that, despite different mechanisms of action, all antineoplastic agents impair the axonal trafficking to some extent and the severity of the neuropathy correlates with the degree of damage on this bidirectional transport. In this paper, we will examine the effect of the main old and new chemotherapeutic drug categories on axonal transport, with
Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, enduring, and often irreversible condition featuring pain, numbness, tingling and sensitivity to cold in the hands and feet (sometimes progressing to the arms and legs) that afflicts between 30% and 40% of patients undergoing chemotherapy. Chemotherapy drugs associated with CIPN include thalidomide, the epothilones such as ixabepilone, the vinca alkaloids vincristine and vinblastine, the taxanes paclitaxel and docetaxel, the proteasome inhibitors such as bortezomib, and the platinum-based drugs cisplatin, oxaliplatin and carboplatin. Whether CIPN arises, and to what degree, is determined by the choice of drug, duration of use, the total amount consumed and whether the patient already has peripheral neuropathy. Though the symptoms are mainly sensory - pain, tingling, numbness and temperature sensitivity - in some cases motor nerves are affected, and occasionally, also, the autonomic nervous system. CIPN often follows the first ...
To update the ASCO guideline on the recommended prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathy (CIPN) in adult cancer survivors.An Expert Panel conducted targeted systematic literature reviews to identify new studies.The search strategy identified 257 new references, which led to a full-text review of 87 manuscripts. A total of 3 systematic reviews, 2 with meta-analyses, and 28 primary trials for prevention of CIPN in addition to 14 primary trials related to treatment of established CIPN, are included in this update.The identified data reconfirmed that no agents are recommended for the prevention of CIPN. The use of acetyl-l-carnitine for the prevention of CIPN in patients with cancer should be discouraged. Furthermore, clinicians should assess the appropriateness of dose delaying, dose reduction, substitutions, or stopping chemotherapy in patients who develop intolerable neuropathy and/or functional impairment. Duloxetine is the only agent ...
Chemotherapy-induced peripheral neuropathy (CIPN), a debilitating major side-effect of malignancy treatment, is definitely seen as a pain and sensory loss at hand and feet. mitochondrial accumulation of p53 in dorsal root ganglia (DRG), spinal cord, and peripheral nerve without evidence for apoptosis. Cisplatin-treatment also reduced mitochondrial membrane potential and lead to abnormal mitochondrial morphology and impaired mitochondrial function in DRG neurons. Pre-treatment with PFT- prevented the early cisplatin-induced increase in mitochondrial p53 and the reduction in mitochondrial membrane potential. Inhibition of the early mitochondrial p53 accumulation by PFT- also prevented the abnormalities buy 936563-96-1 in mitochondrial morphology and mitochondrial bioenergetics (reduced oxygen consumption rate, maximum respiratory capacity, and adenosine triphosphate synthesis) that develop in DRG and peripheral nerve after cisplatin-treatment. Functionally, inhibition of mitochondrial p53 ...
INTRODUCTION: Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and clinically meaningful side effect of cancer treatment. CIPN is induced by neurotoxic agents, causing severe sensory and/or motor deficits, resulting in disability and poor recovery, reducing patients quality of life and limiting medical therapy. To date, effective treatment options are lacking. Whole-body vibration (WBV) training can attenuate motor and sensory deficits. We are conducting a two-armed, multicentre, assessor-blinded, randomised controlled trial, to investigate the effects of WBV on relevant symptoms of CIPN and determine the training characteristics. METHODS AND ANALYSIS: In this ongoing study, 44 patients who have completed therapy in the past 3 months, with a neurologically confirmed CIPN are assessed before and after a 12-week intervention and follow-up. The intervention group receives WBV twice a week. Exercises are individually tailored according to the initially determined optimal ...
Rapid advances have been made in the diagnosis and treatment of neurological disease over the last two decades. Over that period, major developments have also occurred in other fields of medicine, most notably in the management of cancer. Two-thirds of all cancer patients now survive at 5-years post-diagnosis, with over 28 million cancer survivors worldwide.1 As cancer outcomes improve, there has been increased focus on the long-term quality of life in cancer survivors. Not unexpectedly, neurological complications are a prevalent and potentially disabling long-term side effect of cancer treatment. Chemotherapy-induced peripheral neuropathy (CIPN), in particular, is the dose-limiting toxicity of many chemotherapeutic agents, … ...
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most challenging and complex complications of cancer chemotherapy.
Chemotherapy-induced peripheral neuropathy (CIPN) is the most frequent cause of dose reduction or treatment discontinuation in patients treated for cancer with...
ASCO has released a clinical practice guideline on prevention and treatment of chemotherapy-induced peripheral neuropathy in adult cancer patients, published in the Journal of Clinical Oncology.1. The guidelines resulted from the efforts of an expert panel, with representation from the fields of medical oncology, community oncology, nursing, pain research, genetics, neurology, pharmacology, patient representation, and guideline methodology. Charles Loprinzi, MD, of the Mayo Clinic, Rochester, Minnesota, and Dawn Hershman, MD, of Columbia University Medical Center, New York, were the panel co-chairs.. The overall incidence of the condition is estimated at close to 40% in patients treated with multiple agents, with reported rates varying according to chemotherapy regimens, duration of exposure, and assessment methods. Regimens associated with higher risk are those including platinum drugs, vinca alkaloids, bortezomib (Velcade), and taxanes.. Clinical Question. The clinical question addressed by ...
Multivitamin supplements may reduce incidence of chemotherapy-induced peripheral neuropathy among women undergoing treatment with paclitaxel for breast cancer, according to results of a study led by researchers at Roswell Park Comprehensive Cancer Center.“Our study showed that use of multivitamin supplements, but not specific vitamins, was associated with less neurotoxicity,”
TY - JOUR. T1 - A new approach to prevent the chemotherapy-induced peripheral neuropathy. AU - Kawashiri, Takehiro. PY - 2019/1/1. Y1 - 2019/1/1. UR - http://www.scopus.com/inward/record.url?scp=85064722410&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85064722410&partnerID=8YFLogxK. U2 - 10.1254/fpj.153.200. DO - 10.1254/fpj.153.200. M3 - Comment/debate. C2 - 30971662. AN - SCOPUS:85064722410. VL - 153. JO - Folia Pharmacologica Japonica. JF - Folia Pharmacologica Japonica. SN - 0015-5691. IS - 4. ER - ...
This proposal seeks to examine mechanisms of paclitaxel-induced peripheral neuropathy by emphasizing on epidermal damage and the role of the matrix-degrading en...
Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting side effect of many chemotherapeutic agents including vincristine, paclitaxel, cisplatin, oxaliplatin, bortezomib and ixabepilone. Chemotherapy-induced peripheral neuropathy commonly occurs in greater than 40% of patients. To improve the peripheral neuropathy, the chemotherapy dosing is often either decreased or discontinued potentially affecting tumor responsiveness, prognosis, and survival.. There is an unmet medical need for treatment of cancer patients with chemotherapy induced neuropathic pain (CINP) and the proposed study will investigate the efficacy and safety of multiple dose levels of tetrodotoxin (TTX) versus placebo in moderate to severe neuropathic pain caused by chemotherapy. ...
Condition: Chemotherapy-induced Peripheral Neuropathy Intervention: Sponsors: Carsten Dahl Mørch; Aalborg University Hospital Not yet recruiting...
Dublin, Dec. 05, 2018 (GLOBE NEWSWIRE) -- The Chemotherapy-Induced Peripheral Neuropathy (CIPN) - Market Insights, Epidemiology and Market Forecast...
A recent study evaluated the efficacy of cryotherapy for chemo-induced peripheral neuropathy; study participants wore frozen gloves and socks on the dominant side for 90 minutes, including the entire duration of drug infusion.
The USF College of Nursing is pleased to host Ellen M. Lavoie Smith, PhD, APRN, AOCN®, FAAN, who will present Bedside to Bench to Bedside: Managing Painful Chemotherapy-Induced Peripheral Neuropathy at noon on Tuesday, March 5, in MDN 2005. Dr. Smith is an associate professor and director of the PhD program at the University of Michigan School of Nursing. Her program of research is focused on improving the assessment and treatment of chronic, cancer-related neuropathic pain, with a specialty focus in painful chemotherapy-induced peripheral neuropathy. She has received independent research funding from the National Institutes of Health, the Oncology Nursing Society, the American Cancer Society, Dartmouth, and the University of Michigan. Dr. Smith conducted a cross-sectional study evaluating the clinimetric properties of peripheral neuropathy and neuropathic pain measurement approaches. She also completed an Oncology Nursing Society-funded study focused on utilizing quality improvement ...
The USF College of Nursing is pleased to host Ellen M. Lavoie Smith, PhD, APRN, AOCN®, FAAN, who will present Bedside to Bench to Bedside: Managing Painful Chemotherapy-Induced Peripheral Neuropathy at noon on Tuesday, March 5, in MDN 2005. Dr. Smith is an associate professor and director of the PhD program at the University of Michigan School of Nursing. Her program of research is focused on improving the assessment and treatment of chronic, cancer-related neuropathic pain, with a specialty focus in painful chemotherapy-induced peripheral neuropathy. She has received independent research funding from the National Institutes of Health, the Oncology Nursing Society, the American Cancer Society, Dartmouth, and the University of Michigan. Dr. Smith conducted a cross-sectional study evaluating the clinimetric properties of peripheral neuropathy and neuropathic pain measurement approaches. She also completed an Oncology Nursing Society-funded study focused on utilizing quality improvement ...
The main side effects of vincristine are chemotherapy-induced peripheral neuropathy, hyponatremia, constipation, and hair loss. Chemotherapy-induced peripheral neuropathy can be severe, and may be a reason to reduce or avoid using vincristine. The symptoms of this are progressive and enduring tingling numbness, pain and hypersensitivity to cold, beginning in the hands and feet and sometimes affecting the arms and legs.[9] One of the first symptoms of peripheral neuropathy is foot drop: A person with a family history of foot drop and/or Charcot-Marie-Tooth disease (CMT) should avoid the taking of vincristine.[10]. Accidental injection of vinca alkaloids into the spinal canal (intrathecal administration) is highly dangerous, with a mortality rate approaching 100 percent. The medical literature documents cases of ascending paralysis due to massive encephalopathy and spinal nerve demyelination, accompanied by intractable pain, almost uniformly leading to death. Several patients have survived after ...
Chemotherapy can impact or damage the bodys peripheral nerves. Peripheral nerves carry sensations (or neurological messages) to and from the brain and spine, to control feeling and movement in different parts of the body including arms, legs, hands and feet. They also control the bowel and bladder. Damage to peripheral nerves that is caused by chemotherapy is called
Paclitaxel is an effective chemotherapeutic agent widely used for the treatment of solid tumors. The major dose-limiting toxicity of paclitaxel is peripheral neuropathy. The mechanisms underlying the development and maintenance of paclitaxel-induced peripheral neuropathy are still unclear, and there are no currently established effective treatments. Accumulating evidence in models of neuropathic pain in which peripheral nerves are lesioned has implicated spinal microglia and chemokines in pain hypersensitivity, but little is know about their roles in chemotherapy-induced peripheral neuropathy. In the present study, we investigated the role of CC-chemokine ligand 3 (CCL3) in the spinal cord in the development and maintenance of mechanical allodynia using a rat model of paclitaxel-induced neuropathy. Repeated intravenous administration of paclitaxel induced a marked decrease in paw withdrawal threshold in response to mechanical stimulation (mechanical allodynia). In these rats, the number of microglia in
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G. Peripheral Nerve Disorders: Pathology and Genetics is a definitive, clinically-oriented guide to the pathology of peripheral nerve disorders.. These commonly seen neurological challenges have many causes and accurate diagnosis is often necessary via pathological analysis. New techniques exploiting molecular biological knowledge have opened up new vistas to understanding the pathogenesis of these disorders, and hence, their effective management.. This new title takes a disease-oriented approach to understanding the pathology of these conditions. It combines classical and contemporary techniques to enable practitioners in neurology and neuropathology to better understand the disease processes underlying patients presentations and to formulate appropriate management plans.. Peripheral Nerve Disorders: Pathology and Genetics is a valuable resource for neurologists, neuropathologists, pathologists, neurobiologists and geneticists.. Jean-Michel Vallat, Neurology Laboratory, National Referral ...
DESCRIPTION (provided by applicant): Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side-effect arising in ~400,000 cancer patients yearly and often limits chemotherapy dosage. Pain and other quality of life impairments caused by CIPN are increasing as many forms of cancer become chronic conditions, with an estimated annual cost of ~$2.5 billion dollars (NCI Directors Consensus Workshop, June 2011). It has been assumed that as target-specific therapies were discovered, the off-target effect of peripheral neuropathy would lessen. However, as specific mechanism-based therapies (e.g. proteasome and Jak-2 inhibitors) have been introduced, the incidence of painful, chronic neuropathy has persisted at 30-40% of treated patients. Approaches to limit the impact of CIPN include prevention and symptomatic treatment of neuropathic pain. Preventive strategies are complicated by the risk that protection from CIPN may reduce the primary cancer cell killing effect of a drug. Symptomatic ...
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Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and incapacitating complications of tumor treatment. outcomes the group of studies revealed essential lessons which have up to date subsequent function. Some examples of the include the usage of patient-reported indicator metrics the eradication of traditional-yet unsubstantiated-practice techniques as well as the breakthrough of molecular hereditary predictors of neuropathy. Current inquiry has been guided with the outcomes from these large-scale studies and therefore stands better potential for identifying long lasting solutions because of this treatment-limiting toxicity. = 0.003). The magnitude of the power from duloxetine was humble and were even more prominent with neuropathy due to oxaliplatin in comparison to paclitaxel within a subset evaluation. There is a considerably higher occurrence of CTCAE quality 2 or better exhaustion in the duloxetine arm but in any other case the medicine was well-tolerated. Organic ...
Impaired physical function due to chemotherapy-induced peripheral neuropathy (CIPN) symptoms may lead to diminished quality of life. However, even with the knowledge of the effects of CIPN on physical function, clinicians infrequently assess and manage CIPN. Interventions that prioritize the early identification of CIPN to provide prompt treatment may reduce the impact of CIPN on physical function. The purpose of this paper is to compare self-reported physical function in individuals receiving neurotoxic chemotherapy between Electronic Symptom Assessment-Cancer (ESRA-C) intervention group (e.g., opportunity for symptom screening, self-care recommendations, communication coaching, and symptom tracking) and control group participants (i.e., electronic assessment alone). Secondary outcomes include pain intensity, sensory/motor CIPN, depression, fatigue, and insomnia. The data used in this paper are a subset of a randomized controlled trial that examined the impact of the ESRA-C intervention on symptom
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting and disabling side effect of taxane anticancer agents. We prospectively evaluated the efficacy of cryotherapy for CIPN prevention. Methods: Breast cancer patients treated weekly with paclitaxel (80 mg/m2 for one hour) wore frozen gloves and socks on the dominant side for 90 minutes, including the entire duration of drug infusion. Symptoms on the treated sides were compared with those on the untreated (nondominant) sides. The primary end point was CIPN incidence assessed by changes in tactile sensitivity from pretreatment baseline in a monofilament test at a cumulative dose of 960 mg/m2. We also assessed thermosensory deficits, subjective symptoms (Patient Neuropathy Questionnaire [PNQ]), manipulative dexterity, and the time to events and hazard ratio by PNQ. All statistical tests were two-sided. Results: Among the 40 patients, four did not reach the cumulative dose (due to the occurrence of pneumonia, severe ...
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and clinically relevant side effect of chemotherapy. Approximately 50% of all leukemia, lymphoma, colorectal- and breast cancer patients are affected. CIPN is induced by neurotoxic chemotherapeutic agents and can manifest with sensory and/or motor deficits. It is associated with significant disability and poor recovery. Common symptoms include pain, altered sensation, reduced or absent reflexes, muscle weakness, reduced balance control and insecure gait. These symptoms not only affect activities of daily living, subsequently reducing patients quality of life, they have far more become a decisive limiting factor for medical therapy, causing treatment delays, dose reductions, or even discontinuation of therapy, which can affect the outcome and compromise survival. To date, CIPN cannot be prevented and its occurrence presents a diagnostic dilemma since approved and effective treatment options are lacking. Promising results ...
PEA is a fatty acid amide made in the body. It performs a variety of biological functions related to chronic and neuropathic pain and inflammation. These include diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, neuropathic pain, osteoarthritis, low back pain, chronic pelvic pain, post-herpetic neuralgia and neuropathic pain in stroke and MS. To date 20 clinical trials and nearly 2000 patients have been treated with PEA with positive results. Worldwide more than 800,000 patients have been treated with PEA. There has been no reported side-effects or medication interactions.. DIRECTIONS. Take 1 capsule twice a day, then 2 capsules twice a day after a few weeks. Can take up to 4 capsules twice day. Does not need to be taken with food and there is very little interaction with other medications. PEA capsules may be taken with a multi-B vitamin which is beneficial for nerve health, or Turmeric to decrease inflammation. Magnesium Glycinate 200mg capsules are also ...
Another feature review covers the difficult-to-manage syndrome of chemotherapy-induced peripheral neuropathy (CIPN), which is poorly understood physiologically and is clinically manifested in variable fashion in terms of onset and chronicity. Drs Trivedi, Hershman, and Crew provide a very helpful overview on the physiology and clinical spectrum of CIPN, with strategies on surveillance and grading-an approach that should become standard practice. The difficulty in managing CIPN is highlighted, with a review of approaches with demonstrated benefit, but an acknowledgment that responses are variable and far from adequate, highlighting the need for more research and awareness of this common treatment side effect ...
In this online course, the Canadian Physiotherapy Association is assessing Chemotherapy-Induced Peripheral Neuropathy in the pediatric population.
POSTDOCTORAL POSITION IN NEUROPHYSIOLOGY OF CHRONIC PAIN. Team: Fundamental and clinical pharmacology of Pain (http://www. https://neurodol.uca.fr). Location: Laboratoire de Pharmacologie Fondamentale et Clinique de la Douleur, Neuro-Dol (UMR Inserm 1107), Clermont-Ferrand, France. Start date: September 2021. We seek to hire a highly motivated postdoctoral researcher to 1/ characterize HCN activity in brain areas involved in pain processing and to 2/ investigate the efficacy of a new pharmacological strategy of HCN modulation to reduce chronic pain and comorbidities (anxiety and depression) in a mice model of chemotherapy-induced peripheral neuropathy, using a combination of approaches including brain slice electrophysiology, cell imaging, stereotactic brain injections and genetically-modified mice.. The candidate should hold a PhD in Neurobiology or Neuropharmacology and have a solid background in cellular electrophysiology (patch-clamp in brain slices). The candidate should also show strong ...
Duvigneau, S.; Kettner, A.; Carius, L.; Griehl, C.; Findeisen, R.; Kienle, A.: Fast, inexpensive, and reliable HPLC method to determine monomer fractions in poly(3-hydroxybutyrate-co-3-hydroxyvalerate). Applied Microbiology and Biotechnology 105, pp. 4743 - 4749 (2021 ...
Women who take multivitamin supplements before their breast cancer diagnosis and during chemotherapy appear to be less likely to develop the debilitating, often long-lasting symptoms of chemotherapy-induced peripheral neuropathy. Image © NIKITA TV / Shutterstock.com. ...
Toby C. Campbell, MD is a member of the University of Wisconsin Carbone Cancer Center as an associate professor of medicine within the hematology-oncology section of the UW School of Medicine and Public Health as well as chief of the Palliative Care program and program director of the Palliative Care fellowship training program. Dr. Campbell received his medical degree from the University of Virginia and completed his internal medicine residency at the University of Wisconsin Hospital and Clinics. He recently completed fellowships in medical oncology and palliative medicine at Northwestern University.. Dr. Campbells clinical practice interests are in Lung Cancer, symptom management, communication and Palliative Care. His clinical research interests are in lung cancer therapeutics, chemotherapy-induced peripheral neuropathy, symptom management, and interdisciplinary medical teams. He is a member of the American Society of Clinical Oncology, American Association of Hospice and Palliative Medicine ...
Methods 17 gastrointestinal cancer survivors (14 colorectal and 3 gastric cancers), who had been treated with oxaliplatin-based chemotherapies, were recruited. Low-level laser stimulation (50 mW) bilaterally at PC6, PC7, PC8, P9, LU11, SP6, KI3, BL60, KI1, and KI2 was administered for 20 min/point for 12 sessions over 4 weeks. The pain quality assessment scale (PQAS), chemotherapy-induced neurotoxicity questionnaire (CINQ), oxaliplatin-specific neurotoxicity scale (OSNS), quantitative touch-detection threshold (using von Frey filaments), and cold-triggered pain withdrawal latency (using the cold-water immersion test) were measured before and after completion of the 12 treatment sessions. ...
We aimed at validating the role of genetic variants identified by a recent genome-wide association study (GWAS) as determinants of chronic oxaliplatin-induced peripheral neurotoxicity (OXAIPN). Eight polymorphisms (rs10486003, rs2338, rs843748, rs797519, rs4936453, rs12023000, rs17140129, and rs6924 …
Oxaliplatin, the third-generation platinum compound, has evolved as one of the most important therapeutic agents in colorectal cancer chemotherapy. The main limiting factor in oxaliplatin treatment is painful neuropathy that is difficult to treat. This side effect has been studied for several years, but its full mechanism is still inconclusive, and effective treatment does not exist. Data suggest that oxaliplatins initial neurotoxic effect is peripheral and oxidative stress-dependent. A spinal target is also suggested in its mechanism of action. The flavonoids rutin and quercetin have been described as cell-protecting agents because of their antioxidant, antinociceptive, and anti-inflammatory actions. We proposed a preventive effect of these agents on oxaliplatin-induced painful peripheral neuropathy based on their antioxidant properties. Oxaliplatin (1 mg/kg, i.v.) was injected in male Swiss mice, twice a week (total of nine injections). The development of sensory alterations, such as thermal and
StimRouter can change the way healthcare professionals treat chronic peripheral pain by targeting and neuromodulating the affected nerve.
Rieger conducted her research in zebrafish exposed to paclitaxel, a chemotherapeutic agent used for ovarian, breast, lung, pancreatic and other cancers. Paclitaxel-induced peripheral neuropathy affects the majority of treated patients; however, those who are most severely affected (about 30 percent) have to terminate chemotherapy or reduce the dose because of this condition, which can impact cancer survival.. Rieger used zebrafish larvae to model peripheral neuropathy because the embryos develop rapidly and because the larval fish are translucent, making them ideal for studying the progression of nerve degeneration in live animals.. Riegers research showed that paclitaxel induces the degeneration of sensory nerve endings by damaging the outer layer of the skin, or epidermis. The epidermis is innervated by free sensory nerve endings that establish direct contact with skin cells. Her research showed that degeneration is caused by perturbations in the epidermis due to an increase in ...
Peripheral neuropathies are common and affect almost eight percent of the population over age 55. New diagnostic and management options make rational therapies for PN increasingly possible. The high cost of certain diagnostic tests and therapies, along with the complexities involved in choosing which tests and treatments to initiate, complicate the management of patients with PN. Faculty will provide an update on diagnosis and management of diabetic neuropathies, immune axonal neuropathies, and neuropathies associated with hematologic disorders, including ATTR amyloidosis. This program complements Peripheral Neuropathy I: Anatomical Basis and Acquired Demyelinating Neuropathies and Peripheral Neuropathy III: Genetic Neuropathies: Molecular Diagnosis and Treatment Perspectives, but covers independent topics ...
TY - JOUR. T1 - Medial plantar sensory response. Sensitive indicator of peripheral nerve dysfunction in patients with diabetes mellitus. AU - Reeves, Michael L.. AU - Seigler, Deborah E.. AU - Ayyar, D. Ram. AU - Skyler, Jay S.. N1 - Funding Information: From the Departments of Medicine, Pediatrics, Neurology and Diabetes-Endocrinology Unit, University of Miami School of Medicine, Miami, Florida. This work was supported under contracts with the Department of Health and Rehabilitative Services of the State of Florida for the University of Miami/Southeastern Florida Regional Diabetes Program (Health Program Off ice) and for the Regional Diabetes Program for Children and Youth (Childrens Medical Services Prooram). and bv grants from Novo Laboratories,-Inc.:. Wilton, Connecticut, and the Diabetes Research Institute Foundation, Miami, Florida. Requests for reprints should be addressed to Dr. MichaelL . Reeves, University of Miami, Diabetes-Endocrinology Unit (D-l), P.O. pox 016960, Miami, Florida ...
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Integrative Approaches for Cancer-Related Neuropathic Pain by Ilyse Streim, Oncology Massage Therapist Neuropathic pain is a chronic, often debilitating problem that affects a significant number of cancer patients. Peripheral neuropathy is defined as any injury, inflammation, or degeneration of the peripheral nerve fibers. Both chemotherapy and radiation can cause peripheral neuropathy, although chemotherapy-induced peripheral neuropathy…
Peripheral Neuropathy. The most common causes of peripheral neuropathies are diabetes mellitus, vitamin deficiency, alcoholism associated with poor.. There are three main kinds of peripheral nerves - sensory nerves that control. The disease process can be diabetic neuropathy, which is caused by diabetes. Section 9.08 focuses on neuropathy that is in conjunction with diabetes mellitus.. CAUSES OF DIABETIC PERIPHERAL NEUROPATHY ] The REAL cause of Diabetes (and the solution),Causes Of Diabetic Peripheral Neuropathy As was stated earlier in the article diabetes happens a whole lot these days. If you are currently living with it anyone are concerned that you could develop it keep with such simple and tricks in.. May 13, 2016. Symptoms of diabetic peripheral neuropathy (pain, paresthesias, among adults age 18 or older with type 1 or type 2 diabetes mellitus?. Peripheral neuropathy has many forms and causes. Some of the causes are still unknown. The most common cause is diabetes. Other common ...
Diabetic Peripheral Neuropathy-Pipeline Review, H1 2015. Summary. Global Markets Directs, Diabetic Peripheral Neuropathy-Pipeline Review, H1 2015, provides an overview of the Diabetic Peripheral Neuropathys therapeutic pipeline.. This report provides comprehensive information on the therapeutic development for Diabetic Peripheral Neuropathy, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Diabetic Peripheral Neuropathy and special features on late-stage and discontinued projects.. Global Markets Directs report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Directs proprietary databases, ...
Charcot-Marie-Tooth 2B peripheral sensory neuropathy (CMT2B) is a debilitating autosomal dominant hereditary sensory neuropathy. Patients with this disease lose pain sensation and frequently need amputation. Axonal dysfunction and degeneration of peripheral sensory neurons is a major clinical manifestation of CMT2B. However, the cellular and molecular pathogenic mechanisms remain undefined. CMT2B is caused by missense point mutations (L129F, K157N, N161T/I, V162M) in Rab7 GTPase. Strong evidence suggests that the Rab7 mutation(s) enhances the cellular levels of activated Rab7 proteins, thus resulting in increased lysosomal activity and autophagy. As a consequence, trafficking and signaling of neurotrophic factors such as nerve growth factor (NGF) in the long axons of peripheral sensory neurons are particularly vulnerable to premature degradation. A
Treatment for Diabetic Peripheral Neuropathy in Nulife Hospital, Mumbai. Find Doctors Near You, Book Appointment, Consult Online, View Doctor Fees, Address, Phone Numbers and Reviews. Doctors for Diabetic Peripheral Neuropathy in Nulife Hospital, Mumbai | Lybrate
Peripheral neuropathy is a term used to describe damage to nerves of the peripheral nervous system which leads to symptoms such as pain, numbness, tingling, burning, and weakness most commonly affecting the hands and feet. Peripheral neuropathy can be caused by a variety of precipitating factors including trauma, infection, diabetes, alcohol abuse, and cancer chemotherapy.. The incidence of peripheral neuropathy is not known with any degree of certainty. It has been estimated that approximately 2 to 3 million Americans have some form of peripheral neuropathy. The prevalence of peripheral neuropathy worldwide has been estimated to range from 2% to 8% of the population. Peripheral neuropathy affects both genders at all ages but symptoms are unique to each individual in terms of frequency, quality, and severity of pain. Idiopathic peripheral neuropathy typically affects adults over the age of 50. Peripheral neuropathy can significantly impact an individuals quality of life and daily activities by ...
Peripheral neuropathy is a term used to describe damage to nerves of the peripheral nervous system which leads to symptoms such as pain, numbness, tingling, burning, and weakness most commonly affecting the hands and feet. Peripheral neuropathy can be caused by a variety of precipitating factors including trauma, infection, diabetes, alcohol abuse, and cancer chemotherapy.. The incidence of peripheral neuropathy is not known with any degree of certainty. It has been estimated that approximately 2 to 3 million Americans have some form of peripheral neuropathy. The prevalence of peripheral neuropathy worldwide has been estimated to range from 2% to 8% of the population. Peripheral neuropathy affects both genders at all ages but symptoms are unique to each individual in terms of frequency, quality, and severity of pain. Idiopathic peripheral neuropathy typically affects adults over the age of 50. Peripheral neuropathy can significantly impact an individuals quality of life and daily activities by ...
TY - JOUR. T1 - Simplification of the research diagnosis of HIV-associated sensory neuropathy. AU - Evans, Scott R.. AU - Clifford, David B.. AU - Kitch, Douglas W.. AU - Goodkin, Karl. AU - Schifitto, Giovanni. AU - McArthur, Justin Charles. AU - Simpson, David M.. PY - 2008/11. Y1 - 2008/11. N2 - Peripheral neuropathy (PN) is the most common neurological complication of HIV infection, affecting over one third of patients. The research diagnosis of PN is complicated by the need for expensive, time-consuming, and noxious diagnostic tests. We investigated whether nerve conduction studies (NSC) and quantitative sensory tests (QST) provide added value for the diagnosis of PN for research purposes or whether the easily obtainable clinical measures (sensory and motor symptoms, sensitivity to pain and vibration, tendon reflexes, motor function) are sufficient.. AB - Peripheral neuropathy (PN) is the most common neurological complication of HIV infection, affecting over one third of patients. The ...
May 4, 2016. Information on early-onset peripheral neuropathy, a disease VA. evidence to suggest that neuropathy of acute or subacute onset may be.. Clinical Professor, Department of Medical Oncology, Prince of Wales Hospital, Australia and Prince of Wales Clinical School, University of New South Wales.. Small Fiber Sensory Peripheral Neuropathy View FAQs and learn more from Cleveland Clinic about diagnosing small fiber sensory neuropathy with skin biopsies. Find additional resources and staff. Feb 27, 2015. In the last few years weve seen. Mar 19, 2014. Peripheral myelin protein 22 (PMP22)Charcot-Marie-Tooth disease type 1A. Neuropathy type III) is a hereditary neuropathy with early onset and severe presentation. Typically, CIDP shows a subacute or fluctuating course, multi- focal. Although not being a typical transient nerve palsy, sensorineural.. Disorders. All Disorders. NINDS Binswangers Disease Information Page; NINDS Brachial Plexus Injuries Information Page; NINDS Brown-Sequard ...
Obtaining a differential diagnosis is critical to stemming the progression of the disease and beginning the healing process and regeneration of the damaged nerves, if possible. A range of both positive and negative outcomes have been noted in a wide range of medical conditions when using the Tens machine. My feet hurt all the time, I had trouble standing on them for any length of time, going to grade 3 peripheral neuropathy youtube grocery store and walking on concrete floors drove me to tears, and when my neurologist would poke pins in my feet and lower legs, I could not tell they were pushing the pin in there. She required assistance to stand and walked with bilateral support, a wide-based gait, and slow shuffling steps. The length of abnormal enhancement did not correlate with the duration of visual loss prior to the MRI.
TY - JOUR. T1 - Weighted needle pinprick sensory thresholds: a simple test of sensory function in diabetic peripheral neuropathy. AU - Chan, A W AU - MacFarlane, I A AU - Bowsher, David. AU - Campbell, Jacqueline Ann. PY - 1992/1/1. Y1 - 1992/1/1. N2 - A simple device is described, consisting of 12 weighted 23 gauge disposable needles (0.2 to 5.2 g), for testing sensation in busy diabetic clinics. The pinprick sensory threshold (PPT) is the lightest weighted needle which consistently elicits a sharp sensation. The subjects were 48 healthy controls (hospital staff), 44 diabetic patients without neuropathic symptoms, and 35 diabetic patients with chronic painful neuropathy. In the controls, the mean PPT from the right hand and foot obtained on two test occasions a week apart did not differ significantly. In diabetic patients without symptomatic neuropathy, the mean PPT in the right hand and right foot were significantly higher than in the controls. The diabetic patients with painful neuropathy had ...
TY - JOUR. T1 - Postural sway in diabetic peripheral neuropathy among Indian elderly. AU - Dixit, Snehil. AU - Maiya, Arun. AU - Shasthry, B. A.. AU - Kumaran, D. Senthil. AU - Guddattu, Vasudeva. PY - 2015/12/1. Y1 - 2015/12/1. N2 - Background & objectives: Diabetic peripheral neuropathy (DPN) is a major complication of type 2 diabetes and have long term complications on the postural control of the affected population. The objectives of this study were to evaluate postural stability in patients with DPN and to examine correlation of Michigan Neuropathy Screening Instrument (MNSI) with duration of diabetes, age and postural stability measures. Methods: Participants were included if they had clinical neuropathy which was defined by MNSI. Sixty one patients gave their consent to participate in the study and were evaluated on posturography for postural stability measures in four conditions. Repeated measures of analysis of variance (RANOVA) was used to analyze the changes in postural stability ...
TY - JOUR. T1 - Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep. AU - Gore, Mugdha. AU - Brandenburg, Nancy A.. AU - Dukes, Ellen. AU - Hoffman, Deborah L.. AU - Tai, Kei Sing. AU - Stacey, Brett. PY - 2005/10/1. Y1 - 2005/10/1. N2 - Our goal was to evaluate pain severity, pain-related interference with function, sleep impairment, symptom levels of anxiety and depression, and quality of life among patients with painful diabetic peripheral neuropathy (DPN). Participants in a burden of illness survey (n = 255) completed the modified Brief Pain Inventory-DPN (BPI-DPN), MOS Sleep Scale, Hospital Anxiety and Depression Scale (HADS), Short Form Health Survey-12v2 (SF-12v2), and the EuroQoL (EQ-5D). Patients were 61 ± 12.8 years old (51.4% female), had diabetes for 12 ± 10.3 years and painful DPN for 6.4 ± 6.4 years. Average and Worst Pain scores (BPI-DPN, 0-10 scales) were 5.0 ± 2.5 and 5.6 ± 2.8. Pain ...
We conducted a GWAS of paclitaxel-induced cytotoxicity in LCLs and showed significant enrichment of the top cytotoxicity-associated SNPs in a clinical GWAS of paclitaxel-induced sensory peripheral neuropathy in patients with breast cancer. This robust enrichment shows that susceptibilities to increased cytotoxicity in LCLs and sensory peripheral neuropathy in patients with breast cancer likely have some genetic mechanisms in common and supports the role of LCLs as a preclinical model for paclitaxel toxicity studies. Furthermore, the top SNPs that overlap between the 2 studies were enriched for eQTLs. This eQTL enrichment indicates that SNPs associated with paclitaxel-induced toxicity phenotypes may be functioning through gene regulatory mechanisms. Interestingly, neither GWAS alone was enriched for eQTLs. Thus, our integration method may be reducing noise and revealing important functional SNPs. An enrichment of eQTLs has previously been shown in SNPs associated with 6 other chemotherapeutic ...
Polyneuropathy is a common peripheral nerve disorder that often has a well known cause such as diabetes, chronic renal disease, alcohol abuse, vitamin deficiency, hypothyroidism, or use of toxic medication. Elderly people are more often affected, but the differentiation from signs of normal ageing can be difficult. It is important ... read more to diagnose a polyneuropathy and establish the cause at an early stage, because treatment can ameliorate symptoms and prevent progression. Because of the ageing population, the number of people affected by a polyneuropathy can be expected to increase. This thesis deals with questions regarding the efficient work-up and treatment strategies for chronic axonal polyneuropathy. A succinct description of the main study results is as follows. In about 25% of healthy elderly people older than 60 years the vibration sense at the big toes or ankles and the ankle jerks can be absent, and this should be taken into account when developing a clinical diagnostic ...
Peripheral neuropathy may be either inherited or acquired. Causes of acquired peripheral neuropathy include physical injury (trauma) to a nerve, tumors, toxins, autoimmune responses, nutritional deficiencies, alcoholism, and vascular and metabolic disorders. Acquired peripheral neuropathies are grouped into three broad categories: those caused by systemic disease, those caused by trauma from external agents, and those caused by infections or autoimmune disorders affecting nerve tissue. One example of an acquired peripheral neuropathy is trigeminal neuralgia (also known as tic douloureux), in which damage to the trigeminal nerve (the large nerve of the head and face) causes episodic attacks of excruciating, lightning-like pain on one side of the face. In some cases, the cause is an earlier viral infection, pressure on the nerve from a tumor or swollen blood vessel, or, infrequently, multiple sclerosis. In many cases, however, a specific cause cannot be identified. Doctors usually refer to ...
TY - JOUR. T1 - Sural nerve biopsy in peripheral neuropathies. T2 - 30-year experience from a single center. AU - Luigetti, Marco. AU - Di Paolantonio, Andrea. AU - Bisogni, Giulia. AU - Romano, Angela. AU - Conte, Amelia. AU - Barbato, Francesco. AU - Del Grande, Alessandra. AU - Madia, Francesca. AU - Rossini, Paolo Maria. AU - Lauretti, Liverana. AU - Sabatelli, Mario. PY - 2019/10/24. Y1 - 2019/10/24. N2 - INTRODUCTION: Nerve biopsy has been widely used to investigate patients with peripheral neuropathy, and in many centers, it is still a useful diagnostic tool in this setting. In this study, we reviewed the histopathological spectrum of the nerve biopsies performed in our center in a 30-year period and we analyzed their relevance in the clinical setting.MATERIALS AND METHODS: Retrospective analysis of the retrieved data was done for cases of nerve biopsies performed in our institute between 1988 and 2018. Surgical technique and histopathological analysis were done accordingly to standard ...
Professor Hugh Willison is a tenured staff member at the University of Glasgow College of Medicine, Veterinary and Life Science in the Institute of infection Immunity and Inflammation, and also holds an Honorary Clinical Consultant Neurologist contract with the South Glasgow University Hospitals NHS Trust.. He has a specialist interest in peripheral nerve disorders and researches this area at the clinical and laboratory level. In particular, he combines his clinical and research activity on autoimmune diseases including Guillain Barre syndrome and chronic inflammatory neuropathies. He also directs a clinical diagnostic laboratory that conducts immunological tests of relevance to peripheral nerve disorders, including anti-glycolipid, anti-MAG and anti-neuronal antibodies. He received his undergraduate training at the Middlesex Hospital and clinical training in Neurology at the Royal Free Hospital and National Hospital, London.. He received his PhD training in the Myelin and Brain Development ...
TY - JOUR. T1 - Optochiasmatic and peripheral neuropathy due to ethambutol overtreatment. AU - Geyer, Howard L.. AU - Herskovitz, Steven. AU - Slamovits, Thomas L.. AU - Schaumburg, Herbert H.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Ethambutol is known to cause optic neuropathy and, more rarely, axonal polyneuropathy. We characterize the clinical, neurophysiological, and neuroimaging findings in a 72-year-old man who developed visual loss and paresthesias after 11 weeks of exposure to a supratherapeutic dose of ethambutol. This case demonstrates the selective vulnerability of the anterior visual pathways and peripheral nerves to ethambutol toxicity.. AB - Ethambutol is known to cause optic neuropathy and, more rarely, axonal polyneuropathy. We characterize the clinical, neurophysiological, and neuroimaging findings in a 72-year-old man who developed visual loss and paresthesias after 11 weeks of exposure to a supratherapeutic dose of ethambutol. This case demonstrates the selective vulnerability of ...
The Epidermal Nerve Fiber Density (ENFD) test is an objective method of documenting small fiber peripheral neuropathy by quantifying the terminal branches of peripheral nerves within the epidermis. The test is highly specific and sufficiently sensitive with 97% of accuracy rate. The test is recommended to perform when patients experience the following symptoms: pain and abnormal sensation (burning, prickling, shooting), as well as numbness, tightness, coldness in foot/ankle areas.. The common causes of small fiber peripheral neuropathy are: diabetes, types I & II; HIV; vibratory trauma; amyloidosis / monoclonal gammopathy; alcohol abuse; pharmacologic toxins (metronidazole); solvent exposure, and idiopathic neuropathy, when the cause cant be determined, once thought to represent as much as half of all cases.. The ENFD test can also be used to predict the small nerve fiber peripheral neuropathy.. A small 3×3 mm skin biopsy is used for providing diagnostic information on small nerve fibers. The ...
Most common acute motor polyneuropathy, probably due to post-infectious etiology. mycoplasma and campylobacter infections as well as lymphoma have been associated.. Classically, bilateral ascending weakness, may go all the way to the face. Often heralded by paresthesias.. (rarely, there is a descending form Miller Fisher Variant, ataxia, areflexia, & opthalmoplegia). Can develop acutely over days or subacutely over weeks.. motor,,than sensory, almost invariably have decreased reflexes,. If you intubate, DO NOT USE SUX. Consider autonomic dystability.. Get PFTS or ABG. Extensors of neck are quick/dirty test of impending failure. CSF: Albumin-cytologic disassociation: prot,400, WBC,10. In diff, tick paralysis. Rx:. Plasmapheresis. and/or IVIG 0.4 g/kg/day x 2 weeks. (Steroids are safe to give, but probably have no benefit as treatment). ICU Care. occupational and physical therapy. DVT prophylaxis. Splinting to prevent Achilles contractures. Eye Care. Chest PT. Pts are prone to dysrhythmias so ecg ...
Learn about the causes, symptoms, diagnosis & treatment of Peripheral Nerve Disorders from the Home Version of the Merck Manuals.
Learn about the causes, symptoms, diagnosis & treatment of Peripheral Nerve Disorders from the Home Version of the Merck Manuals.
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Read chapter 561 of Rudolphs Pediatrics, 23e online now, exclusively on AccessPediatrics. AccessPediatrics is a subscription-based resource from McGraw Hill that features trusted medical content from the best minds in medicine.
Global Markets Directs, Diabetic Peripheral Neuropathy - Pipeline Review, H1 2020, provides an overview of the Diabetic Peripheral Neuropathy
Peripheral neuropathy includes a wide range of diseases affecting millions around the world, and many of these diseases have unknown etiology. Peripheral neuropathy in diabetes represents a large proportion of peripheral neuropathies. Nerve damage can also be caused by trauma. Peripheral neuropathies are a significant clinical problem and efficient treatments are largely lacking. In the case of a transected nerve, different methods have been used to repair or reconstruct the nerve, including the use of nerve conduits, but functional recovery is usually poor.. Autophagy, a cellular mechanism that recycles damaged proteins, is impaired in the brain in many neurodegenerative diseases affecting animals and humans. No research, however, has investigated the presence of autophagy in the human peripheral nervous system. In this study, I present the first structural evidence of autophagy in human peripheral nerves. I also show that the density of autophagy structures is higher in peripheral nerves of ...
Small fiber and autonomic neuropathies are common but often unrecognized conditions that affect the peripheral, somatic, and autonomic nervous systems. Through the presentation of didactic material and cases of varying complexity, faculty will facilitate a discussion of the pathophysiology, differential diagnosis, diagnostic evaluation, and therapy of these conditions. Part I will focus more heavily on conditions that impact the autonomic nervous system; Part II will focus more heavily on conditions that impact the somatic or sensory nervous system. Both parts will discuss conditions that may impact the sensory and autonomic small fibers simultaneously. This program complements C136: Small Fiber Neuropathies: Sensory, Autonomic, and Both II: Focus on Sensory Nervous System, but covers independent topics ...
Jinmaitong (JMT), a compound prescription of traditional Chinese medicine, has long been used as a therapy for diabetic peripheral neuropathy (DPN). However, the neuroprotective mechanisms of JMT and its effect on gut microbiota remained unknown. Here, we examined the effects of JMT on behavior, pathomorphology and gut microbiota in streptozotocin (STZ)-induced DPN rats. Compared to distilled water administration, JMT reversed decreases in mechanical withdraw threshold and intraepidermal nerve fiber density, improved neurological morphology of sciatic nerves, increased serum neuregulin 1 (NRG1) level and contactin-associated protein (Caspr)-positive paranodes, and decreased amyloid precursor protein (APP) accumulation in DPN rats. More importantly, JMT enriched nine species of the gut microbiota of DPN rats, helping to prevent dysbiosis. Among these species, p_Actinobacteria, p_Proteobacteria and c_Actinobacteria were negatively correlated with DPN phenotypes and positively correlated with serum
TY - JOUR. T1 - Foot Kinetic and Kinematic Profile in Type 2 Diabetes Mellitus with Peripheral Neuropathy A Hospital-Based Study from South India. AU - Hazari, Animesh. AU - Maiya, Arun G.. AU - Shivashankara, K. N.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - BACKGROUND: A kinetic change in the foot such as altered plantar pressure is the most common etiological risk factor for foot ulcers in people with diabetes mellitus. Kinematic alterations in joint angle and spatiotemporal parameters of gait have also been frequently observed in participants with diabetic peripheral neuropathy (DPN). Diabetic peripheral neuropathy leads to various microvascular and macrovascular complications of the foot in type 2 diabetes mellitus. There is a gap in the literature for biomechanical evaluation and assessment of type 2 diabetes mellitus with DPN in the Indian population. We sought to assess and determine the biomechanical changes, including kinetics and kinematics, of the foot in DPN. METHODS: This cross-sectional ...
Diabetic Peripheral Neuropathy (DPN) is the most common complication of diabetes, and often presents as a distal, symmetric, sensorimotor neuropathy. In the United States, 26.8 million people are affected by diabetes; by the year 2030, that number is predicted to increase to approximately 35.9 million people.. In the U.S. alone, the annual total direct medical and treatment costs of diabetes were an estimated $44 billion in 1997, representing 5.8 percent of total personal healthcare expenditures during that year. When it comes to diabetic peripheral neuropathy and its complications, management is resource intensive and long-term, accounting for a large proportion of this total expenditure. In 2001, the total annual cost of diabetic peripheral neuropathy and its complications in the U.S. was estimated to be between $4.6 and $13.7 billion. Up to 27 percent of the direct medical cost of diabetes may be attributed to diabetic peripheral neuropathy.. More than half of patients who have type 1 or 2 ...
Diabetic peripheral neuropathy doesnt emerge overnight. Instead, it usually develops slowly and worsens over time. Some patients have this condition long before they are diagnosed with diabetes. Having diabetes for several years may increase the likelihood of having diabetic neuropathy.. The loss of sensation and other problems associated with nerve damage make a patient prone to developing skin ulcers (open sores) that can become infected and may not heal. This serious complication of diabetes can lead to loss of a foot, a leg, or even a life.. Causes ...
TY - JOUR. T1 - Neuropathic symptoms and their risk factors in medical oncology outpatients with colorectal vs. breast, lung, or prostate cancer. T2 - Results from a prospective multicenter study. AU - Lewis, Mark A.. AU - Zhao, Fengmin. AU - Jones, Desiree. AU - Loprinzi, Charles L.. AU - Brell, Joanna. AU - Weiss, Matthias. AU - Fisch, Michael J.. PY - 2015/6/1. Y1 - 2015/6/1. N2 - Context Few studies have examined the prevalence and severity of treatment-induced neuropathic symptoms in patients across different cancer types. Objectives This study aimed to report the prevalence of numbness/tingling (N/T) and neuropathic pain in patients with colorectal cancer (CRC) vs. other cancers, describe the prevalence of moderate-to-severe N/T by specific clinical variables, and examine factors associated with the presence of these symptoms. Methods A total of 3106 outpatients with colorectal (n = 718), breast (n = 1544), lung (n = 524), or prostate (n = 320) cancer were enrolled at any point in their ...
Information for behavioral health providers in primary care diabetic neuropathies: the nerve damage of diabetes what are diabetic neuropathies?. Nerve damage from diabetes is called diabetic neuropathy (new-rop-uh-thee). about half of all people with diabetes have some form of nerve damage.. Diabetic neuropathies: the nerve damage of diabetes. national institute of diabetes and digestive and kidney diseases. http://diabetes.niddk.nih.gov/dm/pubs.. Reviews the causes and symptoms of diabetic neuropathy and reviews the different types of neuropathies: peripheral, autonomic, proximal, and focal neuropathies.. Peripheral neuropathy. this type of neuropathy is the most common type affecting people with diabetes and can be felt as pain, tingling, burning, prickling, numbness and complete loss of feeling in the extremities. this is nerve damage in the arms and legs.. What is diabetic neuropathy? diabetic neuropathy is a nerve disorder caused by diabetes. symptoms of neuropathy include numbness and ...
The Food and Drug Administration (FDA) has granted NYX-2925 (Aptinyx) Fast Track designation for the potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPN).
Stop the Pain of Diabetic Peripheral Neuropathy is your information source on how to regenerate damaged nerves and restore quality to life.
Of all of the complications that can come with a diabetes diagnosis, diabetic peripheral neuropathy is arguably one of the most challenging. This condition
PubMed journal article: Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial. Download Prime PubMed App to iPhone, iPad, or Android
Zhao T, Zhao H. Acupuncture for symptomatic treatment of diabetic peripheral neuropathy. Cochrane Database of Systematic Reviews 2015, Issue 6. Art. No.: CD006280. DOI: 10.1002/14651858.CD006280. ...
Those at best possible threat for peripheral neuropathy are those over 40 who are diabetic or pre-diabetic and own poorly managed blood sugar ranges. Whilst you smoke or over win pleasure in alcohol, own an autoimmune disease, undergo chemotherapy, own liver or kidney disease, weight loss program deficiencies or mechanical nerve harm (similar to carpal tunnel syndrome) you would possibly per chance per chance per chance additionally furthermore be at threat.. Furthermore, there are a range of medicines which is in a net site to if truth be told motive peripheral neuropathy as a aspect enact. While all of those are things to put an demand on, even whenever you occur to are no longer diabetic, win no medications, and the checklist above does no longer relate to you, you aloof own a likelihood of presenting in some unspecified time in the future in lifestyles with peripheral neuropathy. A whopping 30% of cases dont own any identifiable root motive.. There are over 100 forms of peripheral ...
Hypotension & Severe Peripheral Motor Neuropathy Symptom Checker: Possible causes include Diabetic Autonomic Neuropathy & Autonomic Neuropathy & Guillain-Barré Syndrome. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
What Is Peripheral Neuropathy? What is peripheral neuropathy. It is a problem or distortion affecting nerves, which can cause the sensation impairment, different types of problems in the movement; it can also destroy the gland or organ due to the bad functioning of the nerves. The problem and the damaged part can be recognized by … Continue reading. ...
This syndrome occurs when a rib or a fibrous band of neuropathy b12 deficiency levels compresses the brachial plexus. In the patients with peripheral neuropathy, the changes were distally predominant, affected mainly sensory fibres, and were consistent with an axonal type of neuropathy. In cases of severe or prolonged peripheral neuropathy, you may experience injuries or infections in your extremities. Phase III placebo-controlled trial of capsaicin cream in the management of surgical neuropathic pain in cancer patients. A diagnostic point that may be helpful in the differentiation from a simple entrapment neuropathy of the ulnar nerve at the elbow is that in HD, the enlargement may extend for a greater distance up the arm or may be maximal some distance proximal to the elbow.
Get information, facts, and pictures about Peripheral Neuropathy at Encyclopedia.com. Make research projects and school reports about Peripheral Neuropathy easy with credible articles from our FREE, online encyclopedia and dictionary.
Results: We identified 53 patients who had both ultrasound and MRI of whom 46 (87%) had nerve pathology diagnosed by surgical (n = 39) or clinical/electrodiagnostic (n = 14) evaluation. Ultrasound detected the diagnosed nerve pathology (true positive) more often than MRI (43/46 vs 31/46, p , 0.001). Nerve pathology was correctly excluded (true negative) with equal frequency by MRI and ultrasound (both 6/7). In 25% (13/53), ultrasound was accurate (true positive or true negative) when MRI was not. These pathologies were typically (10/13) long (,2 cm) and only occasionally (2/13) outside the MRI field of view. MRI missed multifocal pathology identified with ultrasound in 6 of 7 patients, often (5/7) because pathology was outside the MRI field of view. ...
In the peripheral nervous system (PNS), the disease is more severe. While most nervous system diseases affect either central ... nervous system (CNS) or PNS, this disease affects both, but the changes in the PNS lead to death. This occurs by axonal disease ... neuropathological features in the central and peripheral nervous system". Modern Pathology. 29 (9): 962-976. doi:10.1038/ ... Genetic diseases and disorders, Syndromes affecting the nervous system). ...
Central nervous system disease Peripheral neuropathy "Nervous System Diseases - Neurologic Diseases". MedlinePlus. Retrieved ... "Central nervous system: Structure, function, and diseases". 22 December 2017. "Peripheral Nervous System". www.indiana.edu. " ... The nerves connect to the peripheral nervous system. The peripheral nervous system connects to the muscles and glands and sends ... Nervous system diseases, also known as nervous system or neurological disorders, refers to a small class of medical conditions ...
They could include diseases or disorders in the central nervous system or peripheral nervous system. Examples of neuropathic ... or changes in hormonal balances associated with aging Terminal illness Itch can originate in the peripheral nervous system ( ... or in the central nervous system (neuropathic, neurogenic, or psychogenic). Itch originating in the skin is known as ... for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010". ...
Some patients with systemic vasculitis will have their multi-organ disease spread to the peripheral nervous system; this is ... It can be as part of a systemic problem or can exist as a single-organ issue only affecting the peripheral nervous system (PNS ... Vasculitic neuropathy is a peripheral neuropathic disease. In a vasculitic neuropathy there is damage to the vessels that ... Infectious diseases: hepatitis B, hepatitis C, human immunodeficiency virus (HIV), cytomegalovirus, lyme disease, human T-cell- ...
Neurology works with diseases of the central and peripheral nervous systems, such as amyotrophic lateral sclerosis (ALS) and ... Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its ... the central nervous system (defined as the brain and spinal cord), and the peripheral nervous system. In many species - ... Neurosurgery and psychosurgery work primarily with surgical treatment of diseases of the central and peripheral nervous systems ...
Wight, P. a. L. (1960). A histological study of the spinal cord and peripheral nervous system in scrapie disease of sheep ( ... As these involve the animal's nervous system he moved onto the field of neuropathology. In 1956, he returned to Britain to work ... The Histopathology of Marek's Disease Oregon Disease in Turkeys Who's Who in Commerce and Industry vol 14 SILLER, WALTER G. " ... Here he mainly worked on mainstream African animal diseases such as Heartwater and Rabies. ...
... a broad term describing any disease process which affects the peripheral nervous system. However, neuropathies may be due to ... 20 (5 Peripheral Nervous System Disorders): 1274-92. doi:10.1212/01.CON.0000455881.83803.a9. PMID 25299282. S2CID 35635940. " ... Neuritis (/njʊəˈraɪtɪs/) is inflammation of a nerve or the general inflammation of the peripheral nervous system. Inflammation ... CS1 maint: others, Articles with short description, Short description is different from Wikidata, Peripheral nervous system ...
It is a disease of the peripheral nervous system, caused by a mutation in one of two myelin genes. Roussy and Lévy published ... his investigations on the role of the thalamus and the autonomic nervous system. During World War I he was chief of neurology ... A hereditary disease that is usually first noticed in infancy. Named with Dr. Gabrielle Lévy. Les psychonévroses de guerre, ... "Roussy-Lévy disease": spinocerebellar degeneration with muscular atrophy of the lower limbs, sensory ataxia, plus other ...
... is a group of autosomal dominant inherited neurological diseases that affect the peripheral nervous system particularly on the ... They accumulate in the peripheral nervous system where HSAN manifest, but not in the central nervous system in mice bearing a ... Peripheral nervous system disorders, Rare diseases, Neurogenetic disorders). ... However, information on the expression of the gene in the peripheral nervous system is still lacking. In fruit fly (Drosophila ...
It is a disease of the peripheral nervous system, caused by a mutation in one of two myelin genes. Roussy and Lévy published ... She suffered from a severe disease of the nervous system, which she diagnosed herself, but she remained lucid until the end. ... An obituary published in the Journal of Nervous and Mental Disease describes her as having "qualities of intense application ... "Gabrielle Lévy, M.d". The Journal of Nervous and Mental Disease. 81 (6): 725. June 1935. doi:10.1097/00005053-193506000-00066. ...
This coordination can be disrupted by damage or diseases of the central nervous system, peripheral nerves or autonomic nervous ... refers to urinary bladder problems due to disease or injury of the central nervous system or peripheral nerves involved in the ... peripheral nerve damage, Parkinson's disease, or other neurodegenerative diseases. Neurogenic bladder can be diagnosed through ... Peripheral nerves can also be damaged as a complication of major surgery of the pelvis, such as for removal of tumors. The ...
Hence, he believed the entire body-all the organs, glands and peripheral nervous system-was implicated in the natural disease ... The Journal of Nervous and Mental Disease. 200 (12): 1022-30. doi:10.1097/NMD.0b013e318275cf19. PMID 23197117. S2CID 41939669 ... Bleuler later expanded his new disease concept into a monograph in 1911, which was finally translated into English in 1950. ... According to some scholars, the disease has always existed only to be 'discovered' during the early 20th century. The ...
These diagnostic tests of the peripheral nervous system, especially useful in evaluating diseases of the muscles, nerves, and ... Electrodiagnostic medicine focuses only on the peripheral nervous system and not the central nervous system. Whereas a clinical ... the pathophysiology along with clinical methods used to diagnose diseases involving both central and peripheral nervous systems ... Clinical neurophysiology is a medical specialty that studies the central and peripheral nervous systems through the recording ...
Peripheral nervous system diseases may be further categorized by the type of nerve cell (motor, sensory, or both) affected by ... complex disorders linked by the degeneration of neurons in either the peripheral nervous system or the central nervous system. ... Neurodegenerative diseases of the central nervous system can affect the brain and/or spinal cord. This article will cover the ... Disease: amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Huntington's disease (HD), spinal muscular atrophy (SMA ...
... especially as relating to the pathophysiology underlying diseases of the central and peripheral nervous system. It is the ...
Reilly, Mary M.; Murphy, Sinéad M.; Laurá, Matilde (2011). "Charcot-Marie-Tooth disease". Journal of the Peripheral Nervous ... System. 16 (1): 1-14. doi:10.1111/j.1529-8027.2011.00324.x. ISSN 1529-8027. PMID 21504497. "First clinical trial for Charcot ... She began to study neuromuscular disease, in particular Charcot-Marie-Tooth disease. In 2004, she found that Vitamin C could be ... Reilly has served as President of the British Peripheral Nerve Society and the International Peripheral Nerve Society. In 2015 ...
... diseases of the peripheral nervous system, dermatological diseases, respiratory and other disorders. The marine climate has hot ... Here you can treat degenerative, inflammatory and diarthritic rheumatic diseases, post-traumatic states, ...
... peripheral, and autonomic nervous systems. Stroke Parkinson's disease Alzheimer's disease Huntington's disease Multiple ... History of neuroscience Outline of the human nervous system Action potential Acetylcholinesterase Central nervous system (CNS) ... Neurophysiology is the study of the function (as opposed to structure) of the nervous system. Brain mapping Electrophysiology ... Neural oscillation Molecular neuroscience is a branch of neuroscience that examines the biology of the nervous system with ...
Vascular diseases, Peripheral nervous system disorders, Sensitivities). ... the cardiovascular system, the nervous system, and circulation control system. Orthostatic intolerance is divided, roughly ... OI can be a subcategory of dysautonomia, a disorder of the autonomic nervous system occurring when an individual stands up. ...
A neuromuscular disease is any disease affecting the peripheral nervous system (PNS), the neuromuscular junction, or skeletal ... a part of the central nervous system. However, the anterior horn is also part of the motor unit. Diseases that affect the ... Prognosis and management vary by disease.[citation needed] List of neuromuscular disorders Motor neuron diseases Neuromuscular ... such as the failure of the body's system for absorbing vitamin B-12. Diseases of the motor end plate include myasthenia gravis ...
Peripheral nervous system disorders, Cytomegalovirus-associated diseases, HIV/AIDS, All stub articles, Nervous system disease ... that CMV polyradiculomyelopathy should be treated with both ganciclovir and foscarnet in patients who develop the disease while ...
The following diseases can be treated here: orthopedic and traumatic, nervous, rheumatological, peripheral nervous system, skin ...
... motor neuron disease, peripheral neuropathy, and other diseases of the nervous system". J. Neuroimmunol. 56 (1): 27-33. doi: ... 1989). "Total, anti-viral, and anti-myelin IgG subclass reactivity in inflammatory diseases of the central nervous system". J. ... 2006). "Anti-ganglioside antibodies in coeliac disease with neurological disorders". Digestive and Liver Disease. 38 (3): 183-7 ... Antibodies to ganglioside are found to be elevated in coeliac disease. Recent studies show that gliadin can cross-link to ...
... (CIDP) is an acquired autoimmune disease of the peripheral nervous system ... Journal of the Peripheral Nervous System. 10 (3): 329-337. doi:10.1111/j.1085-9489.2005.10311.x. PMID 16221292. S2CID 24896124 ... Ultrasound of the peripheral nerves may show swelling of the affected nerves. Magnetic resonance imaging can also be used in ... Fatigue has been identified as common in CIDP patients, but it is unclear how much this is due to primary (due to the disease ...
A synaptopathy is a disease of the brain, spinal cord or peripheral nervous system relating to the dysfunction of synapses. ... Some diseases of unknown etiology have been proposed to be synaptopathies. Examples include autism spectrum disorder and ... Increasing knowledge of the genetic basis of these diseases has linked proteins to the function of the synapse. Age-related ... Another example of synaptopathy occurs in the auditory system. This cochlear synaptopathy has been seen after prolonged noise ...
... a genetically and clinically heterogeneous group of inherited disorders of the peripheral nervous system characterized by ... Abrams, Charles K.; Rash, John E. (2009). "Connexins in the Nervous System". In Harris, Andrew; Locke, Darren (eds.). Connexins ... Classifications of Charcot-Marie-Tooth disease refers to the types and subtypes of Charcot-Marie-Tooth disease (CMT), ... 1997). "New Mutations in the X-Linked Form of Charcot-Marie-Tooth Disease". European Neurology. 37 (1): 38-42. doi:10.1159/ ...
... (CMT) is a hereditary motor and sensory neuropathy of the peripheral nervous system characterized ... Peripheral nervous system disorders, Cytoskeletal defects, Syndromes affecting the nervous system). ... "Neurophysiologic abnormalities in children with Charcot-Marie-Tooth disease type 1A". Journal of the Peripheral Nervous System ... In 2010, CMT was one of the first diseases where the genetic cause of a particular patient's disease was precisely determined ...
... even expert neurologists experienced in the diagnosis of diseases of the peripheral nervous system may not previously have ... Motor neuron diseases, Rare diseases, Unsolved problems in neuroscience, All stub articles, Nervous system disease stubs). ... Facial onset sensory and motor neuronopathy, often abbreviated FOSMN, is a rare disorder of the nervous system in which sensory ... In common with many neurological diseases, there is no one 'test' for FOSMN. The diagnosis can be notoriously difficult, mainly ...
Charcot-Marie-Tooth (CMT) is the most frequent heritable disorder of the peripheral nervous system (a neuronal disease) and is ... Diabetes, a metabolic disease, induces oxidative stress, which triggers a build up of mitochondrial tRNA mutations. It has also ... Depletion of the other substrate of aminoacyl-tRNA synthetases, the cognate tRNA, may be relevant to certain diseases, e.g. ... Certain diseases' causation (such as neuronal pathologies, cancer, disturbed metabolic conditions, and autoimmune disorders) ...
Demyelinating diseases can be divided in those affecting the central nervous system (CNS) and those affecting the peripheral ... The demyelinating diseases of the peripheral nervous system include:[citation needed] Guillain-Barré syndrome and its chronic ... A demyelinating disease is any disease of the nervous system in which the myelin sheath of neurons is damaged. This damage ... Both myelinoclastic and leukodystrophic modes of disease may result in lesional demyelinations of the central nervous system. ...
Rare diseases, Neurodegenerative disorders, Peripheral nervous system disorders). ... Parkinson's disease and multiple system atrophy, being the first process to give an objective diagnosis of Multiple System ... The region in question includes the SHC2 gene which, in mice and rats, appears to have some function in the nervous system. The ... Many people affected by MSA experience dysfunction of the autonomic nervous system, which commonly manifests as orthostatic ...
Axons in the central nervous system do not regenerate after injury the same way that axons in the peripheral nervous system do ... Mutations to the MAG gene are implicated in demyelination diseases such as multiple sclerosis. ... Lopez PH (2014). "Role of myelin-associated glycoprotein (siglec-4a) in the nervous system". Advances in Neurobiology. 9: 245- ... Lopez PH (2014). "Role of myelin-associated glycoprotein (siglec-4a) in the nervous system". Advances in Neurobiology. 9: 245- ...
Child's Nervous System. 25 (1): 13-20. doi:10.1007/s00381-008-0701-x. PMID 18818933. S2CID 30117644. Carter CJ (November 2009 ... "The peripheral blood mononuclear cell microRNA signature of coronary artery disease". Biochemical and Biophysical Research ...
Coniine acts directly on the central nervous system through inhibitory action on nicotinic acetylcholine receptors. In high ... The alkaloid content found in C. maculatum also affects the thermoregulatory centre by a phenomenon called peripheral ... Avian Diseases. 34 (2): 433-437. doi:10.2307/1591432. JSTOR 1591432. PMID 2369382. Blamey, M.; Fitter, R.; Fitter, A. (2003). ...
... sprue Cenani-Lenz syndactylism Cennamo-Gangemi syndrome Central core disease Central diabetes insipidus Central nervous system ... late infantile Cervical cancer Cervical hypertrichosis neuropathy Cervical hypertrichosis peripheral neuropathy Cervical ribs ... Marie-Tooth disease type 1A Charcot-Marie-Tooth disease type 1B Charcot-Marie-Tooth disease type 1C Charcot-Marie-Tooth disease ... Marie-Tooth disease type 2C Charcot-Marie-Tooth disease type 2D Charcot-Marie-Tooth disease type 4A Charcot-Marie-Tooth disease ...
"Peripheral Solutions to Peripheral Development: The Case of Early 20th Century Romania" (PDF file), in Journal of World Systems ... culminating in Brătianu's arrival to power after the premier fell victim to a nervous disease -, Stere replaced Petre Poni at ... At the time, a physician who examined him noted that he had suffered a nervous breakdown, and had him moved to a prison ...
The involvement of both the central and peripheral nervous system in COVID‑19 has been reported in many medical publications. ... Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a virus, the severe acute respiratory syndrome ... The virus is not detected in the central nervous system (CNS) of the majority of COVID-19 patients with neurological issues. ... The cells of the central nervous system, the microglia, neurons, and astrocytes, are also involved in the release of pro- ...
The peripheral nervous system is made up of these spinal roots, nerves, and ganglia. The dorsal roots are afferent fascicles, ... Spinal cord injury can also be non-traumatic and caused by disease (transverse myelitis, polio, spina bifida, Friedreich's ... The spinal cord is the main pathway for information connecting the brain and peripheral nervous system. Much shorter than its ... These rootlets form the demarcation between the central and peripheral nervous systems.[citation needed] Generally, the spinal ...
... peripheral nervous system, liver, spleen, and bone marrow. Inside cells under normal conditions, lysosomes convert, or ... Members of this group include Niemann-Pick disease, Fabry disease, Krabbe disease, Gaucher disease, Tay-Sachs disease, ... Xanthomatosis Niemann-Pick disease "Lipid Storage Diseases Fact Sheet". National Institute of Neurological Disorders and Stroke ... Enzyme replacement therapy is available mainly to treat Fabry disease and Gaucher disease and people with these types of ...
... s are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where ... "Histamine H3 Receptor as a Potential Target for Cognitive Symptoms in Neuropsychiatric Diseases." Behavioural Brain Research ... Central nervous system Peripheral nervous system Heart Lungs Gastrointestinal tract Endothelial cells Like all histamine ... because it is linked to the central nervous system and its regulation of other neurotransmitters. Examples of such disorders ...
The sympathoadrenal system is a physiological connection between the sympathetic nervous system and the adrenal medulla and is ... Schrier, Robert W (1999). Atlas of Diseases of the Kidney. Philadelphia, PA: Blackwell Science. pp. Volume 3. Bray, George A ( ... Together, the effects increase peripheral blood pressure, but decrease central blood pressure. This can have larger effects on ... the brain acts on the central nervous system by crossing the blood-brain barrier and affecting the sympathetic nervous system. ...
... peripheral nervous system, and central nervous system. B. Burgdorferi does not produce toxins. Therefore, many of the signs and ... Halperin JJ (June 2008). "Nervous system Lyme disease". Infectious Disease Clinics of North America. 22 (2): 261-74, vi. doi: ... Lyme disease organizations at Curlie CDC - Lyme Disease Lyme Disease Tests - Lab Tests Online NIH - Lyme Disease NICE ... Lyme disease can affect several body systems and produce a broad range of symptoms. Not everyone with Lyme disease has all of ...
Although the disease is the basis for this type of neurolysis, other diseases such as peripheral neuralgia or vasospastic ... A neurolytic agent such as alcohol, phenol, or glycerol is typically injected into the nervous system. Chemical neurolysis ... Peripheral nerves move (glide) across bones and muscles. A peripheral nerve can be trapped by scarring of surrounding tissue ... "External Neurolysis (peripheral nerve disorders) , Department of Neurosurgery". med.nyu.edu. Retrieved 2020-04-24. Bahn, Bret M ...
The mGluRs perform a variety of functions in the central and peripheral nervous systems: For example, they are involved in ... Platt SR (March 2007). "The role of glutamate in central nervous system health and disease--a review". Veterinary Journal. 173 ... Also, some researchers have suggested that activation of mGluR4 could be used as a treatment for Parkinson's disease. Most ... More recent reports on ionotropic glutamate receptors able to couple to metabotropic transduction systems suggest that ...
... is a motor speech disorder resulting from damage to peripheral nervous system (cranial or spinal nerves) or ... Demyelinating disorders Infectious/Inflammatory Degenerative disorders Metabolic Neoplastic Traumatic Vascular Diseases Flaccid ... lower motor neuron system. Depending on which nerves are damaged, flaccid dysarthria affects respiration, phonation, resonance ...
Also affected are the hypothalamus, spinal cord and peripheral nervous system-autonomic dysfunction. The European Federation of ... as diseases of the nervous system, code 31.8. Diagnostic tests can be used to establish some features of the condition and ... Several areas of the nervous system (such as the autonomic nervous system and numerous regions of the brain) can be affected by ... Lewy pathology affects the peripheral autonomic nervous system; autonomic dysfunction is observed less often in AD, ...
"Interim Treatment Guidance for Central Nervous System and Parameningeal Infections Associated with Injection of Contaminated ... Additionally, very common adverse effects, occurring in more than 10% of people, include peripheral edema, headaches, trouble ... August 2016). "Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases ... "Voriconazole". The American Society of Health-System Pharmacists. Retrieved 8 December 2017. Kendig EL, Wilmott RW, Chernick V ...
... s, All stub articles, Nervous system drug stubs). ... COMT inhibitors are indicated for the treatment of Parkinson's disease in combination with levodopa and an aromatic L-amino ... Entacapone and opicapone are peripheral inhibitors, unable to cross the blood-brain barrier. Tolcapone is able to cross the ... Scott, Lesley J. (2016-08-06). "Opicapone: A Review in Parkinson's Disease". Drugs. 76 (13): 1293-1300. doi:10.1007/s40265-016- ...
Neurosteroids are synthesized in the central nervous system (CNS) and the peripheral nervous system (PNS) from cholesterol and ... Neuropsychiatric Disease and Treatment. 1 (4): 329-43. PMC 2424120. PMID 18568113. Rudolph U, Knoflach F (Sep 2011). "Beyond ... Baulieu EE (1997). "Neurosteroids: of the nervous system, by the nervous system, for the nervous system". Recent Progress in ... GABA is a major inhibitory neurotransmitter in the central nervous system. Upon binding, it triggers the GABAA receptor to open ...
A prion disease called kuru has been traced to this. Brain-computer interface Central nervous system disease List of ... Some basic types of responsiveness such as reflexes can be mediated by the spinal cord or peripheral ganglia, but sophisticated ... Except for a few primitive organisms such as sponges (which have no nervous system) and cnidarians (which have a nervous system ... and neurology is the medical discipline that diagnoses and treats diseases of the nervous system. The brain is also the most ...
Wood-allum, Clare A.; Shaw, Pamela J. (2014). "Thyroid disease and the nervous system". Neurologic Aspects of Systemic Disease ... "nervous system" and -pathy, "disease of") without modifier usually means peripheral neuropathy. Neuropathy affecting just one ... non-sensory nervous system (i.e., the autonomic nervous system), affecting mostly the internal organs such as the bladder ... Testing for small-fiber peripheral neuropathies often relates to the autonomic nervous system function of small thinly- and ...
July 2015). "Structural and functional features of central nervous system lymphatic vessels". Nature. 523 (7560): 337-41. doi: ... ISBN 978-0-323-54800-7. Anrather J (2017-01-01). "Chapter 28 - Pathophysiology of the Peripheral Immune Response in Acute ... Ischemic Stroke". In Caplan LR, Biller J, Leary MC, Lo EH (eds.). Primer on Cerebrovascular Diseases (Second ed.). San Diego: ...
Central nervous system effects such as hallucinations or confusion have been observed in rare cases, attributed mostly to ... This side effect is more likely to occur in people with pre-existing cardiac disease, or with the use of other medicines known ... Levander S, Ståhle-Bäckdahl M, Hägermark O (1 September 1991). "Peripheral antihistamine and central sedative effects of single ... These have also been confirmed in both recent and past studies to have no adverse effects on the liver, blood, nervous system, ...
Central nervous system involvement may cause strokes or seizures.[citation needed] Renal system: Kidney involvement is common ... The medical eponyms Kussmaul disease or Kussmaul-Maier disease reflect the seminal description of the disease in the medical ... Neurologic system: Nerve involvement may cause sensory changes with numbness, pain, burning, and weakness (peripheral ... These manifestations result from ischemic damage to affected organs, often the skin, heart, kidneys, and nervous system. ...
Wheeler G, Ntounia-Fousara S, Granda B, Rathjen T, Dalmay T (April 2006). "Identification of new central nervous system ... "Differential microRNA expression in peripheral blood mononuclear cells from Graves' disease patients". The Journal of Clinical ...
"Peripheral and Central Nervous System Advisory Committee Background Package on Azilect" (PDF). FDA. Retrieved December 7, 2011 ... that it actually prevented the death of the dopaminergic neurons that characterize Parkinson's disease and slowed disease ... Parkinson's disease is characterized by the death of cells that produce dopamine, a neurotransmitter. An enzyme called ... Selegiline Ladostigil Akao Y, Maruyama W, Yi H, Shamoto-Nagai M, Youdim MB, Naoi M (June 2002). "An anti-Parkinson's disease ...
"Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T ... host disease. The specific cell-surface markers for Tr1 cells in humans and mice are CD4+ CD49b+LAG-3+ CD226+ from which LAG-3+ ... Tr1 cells are self or non-self antigen specific and their key role is to induce and maintain peripheral tolerance and suppress ... Phase I/II of clinical trials of Tr1 cell treatment concerning Crohn's disease have been successful and appear to be safe and ...
Spinocerebellar degeneration is a rare inherited neurological disorder of the central nervous system characterized by the slow ... Many SCAs below fall under the category of polyglutamine diseases, which are caused when a disease-associated protein (i.e., ... peripheral neuropathy, seizures, among others. As with other forms of ataxia, SCA frequently results in atrophy of the ... Both onset of initial symptoms and duration of disease are variable. If the disease is caused by a polyglutamine trinucleotide ...
... and pain affect the vestibular system and the central nervous system which can cause the symptom of disequilibrium. Balance ... vascular system, fluid or blood volume, spinal cord, peripheral nerves, or body electrolytes. Dizziness can accompany certain ... Medical conditions that often have dizziness as a symptom include: Benign paroxysmal positional vertigo Ménière's disease ... This sensation can originate in the inner ear or other motion sensors, or in the central nervous system. Neurologic disorders ...
These highly specialized glial cells wrap and electrically insulate axons in the peripheral and central nervous system, ... This line of research helps us to understand the molecular mechanisms of human neurological diseases in which genetic mutations ... A major focus of their research is on neuron-glia interactions that result in the assembly of myelin in the nervous system. ... focuses on molecular mechanisms of synapse development and function in the mammalian central nervous system. For that purpose, ...
has_disease_location some (peripheral nervous system or part of some peripheral nervous system) ... has_disease_location some (peripheral nervous system or part of some peripheral nervous system) ... peripheral nervous system disease. Go to external page http://www.ebi.ac.uk/efo/EFO_0009387 Copy ... A disease involving the peripheral nervous system. [ https://orcid.org/0000-0002-6601-2165 ] ...
Symptomatic treatment of painful diseases of the peripheral nervous system with a combination preparation of thiamine, ... Peripheral Nervous System Diseases / drug therapy* * Peripheral Nervous System Diseases / etiology * Pyridoxine / ...
Results of search for su:{Peripheral nervous system diseases} Refine your search. *. Availability. * Limit to currently ... The physiology of peripheral nerve disease / Austin J. Sumner. by Sumner, Austin J. ... Peripheral neuropathies : report of a WHO study group [meeting held in Geneva from 1 to 4 October 1979] by WHO Study Group on ... by WHO Study Group on Peripheral Neuropathies , World Health Organization.. Series: Organisation mondiale de la Santé. Série de ...
Learn about neuropathy and more than 100 other types of peripheral nerve disorders. ... Peripheral nerves are nerves outside your brain and spinal cord. ... Peripheral Nervous System Diseases (National Institutes of ... What are peripheral nerve disorders?. Peripheral nerve disorders happen when one or more peripheral nerves are damaged. Damaged ... What Are the Parts of the Nervous System? (Eunice Kennedy Shriver National Institute of Child Health and Human Development) ...
"Journal of the Peripheral Nervous System. 7 (4): 229-32. doi:10.1046/j.1529-8027.2002.02030.x. PMID 12477169.. ... Also, the disease can be diagnosed by a positive "middle finger test", where resisted middle finger extension produces pain. ... "Examination of peripheral nerve injuries: an anatomical approach. Stuttgart: Thieme. p. 62. ISBN 978-3-13-143071-7. .. ... The chief complaint of this disease is usually pain in the dorsal aspect of the upper forearm, and any weakness described is ...
Peripheral Nervous System Diseases. Neuromuscular Diseases. Nervous System Diseases. Polyradiculoneuropathy. Autoimmune ... Diseases of the Nervous System. Demyelinating Diseases. Autoimmune Diseases. Immune System Diseases. ... Genetic and Rare Diseases Information Center resources: Chronic Graft Versus Host Disease Chronic Inflammatory Demyelinating ... Condition or disease Intervention/treatment Phase Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Biological: ...
Nervous System Lyme Borreliosis; Neuroborreliosis, Borrelia burgdorferi; Peripheral Nervous System Lyme Disease. On-line free ... Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms ... and late persistent disease. Neuroborreliosis, infection of the nervous system by B. burgdorferi, may occur during early ... Concurrent infection of the central nervous system by borrelia burgdorferi and bartonella henselae: evidence for a novel tick- ...
Disease should be diagnosed by using the Brighton Collaboration case definitions and cerebrospinal fluid IgM reactivity. ... neurotropic disease; MoH, Ministry of Health; PNS, autoimmune neurologic disease with peripheral nervous system involvement; YF ... autoimmune neurologic disease with central nervous system involvement; CSF, cerebrospinal fluid; IQR, interquartile range; NA, ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ...
... and peripheral nerves has been recognized in several clinical and postmortem case reports and series by Combe, Addison, and ... Metz J. Cobalamin deficiency and the pathogenesis of nervous system disease. Annu Rev Nutr. 1992. 12:59-79. [QxMD MEDLINE Link] ... Vitamin B12 deficiency and nervous system disease in HIV infection. Arch Neurol. 1993 Aug. 50(8):807-11. [QxMD MEDLINE Link]. ... Vitamin B-12 role in the peripheral and central nervous systems. The neurologic manifestation of cobalamin deficiency is less ...
Peripheral Nervous System Diseases [‎5]‎. Personnel Management [‎47]‎. Personnel Selection [‎6]‎. Pharmaceutical Preparations ...
Categories: Peripheral Nervous System Diseases Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ...
Symptoms of autoimmune diseases can include fatigue, aching joints and muscles, inflammation, hair loss, and rashes. Learn more ... Peripheral nervous system manifestations in systemic autoimmune diseases. Maedica (Bucur). 2014;9(3):289-294. ... Guillain-Barré syndrome (GBS) results from an immune system attack on the peripheral nervous system, usually after a bacterial ... Celiac Disease Celiac disease occurs when the immune system attacks the lining of the small intestines in response to gluten, a ...
epidemiological studies; central nervous system; rabies; sheep; peripheral nervous system diseases; strain differences; signs ... disease reservoirs; disease prevalence; disease transmission; digestive system diseases; anti-infective agents; Portugal. ... type III secretion system; intestinal mucosa; mutants; digestive system diseases; Escherichia coli O157; disease resistance; ... Aujeszky disease; isomers; disease resistance; immune response; immune system; pathogenesis; biochemical mechanisms; disease ...
... neurochemistry and molecular mechanisms of the central and peripheral nervous systems in health and disease. ... musculoskeletal system, peripheral nervous system and vascular supply to the trunk, head and neck, limbs, and back. ... of human diseases and understanding how physiological systems interact in order to maintain homeostasis in health and disease. ... organization and current research-based concepts of the human nervous system. Emphasis on fundamental knowledge of the ...
... is the most common clinical genetic disease of the peripheral nervous system. Although many studies have focused on elucidating ... The biological function enrichment analysis suggested that myelin sheath, axon, peripheral nervous system, mitochondrial ... a systematic analysis of biology to decode the underlying pathological molecular mechanisms and the mechanism of its disease ... peripheral nervous system development, myelination in peripheral nervous system, and peripheral nervous system axon ...
Central and Peripheral Nervous System, Neuromuscular Disease & Disorders w/Dr. Esfahani. day:. Wednesday. date:. 08/03/2022. ... ANES) Residents Split Curriculum - CA0/1s: Central and Peripheral Nervous System, Neuromuscular Disease & Disorders w/Dr. ... Infectious Diseases Infectious Diseases & International Health Infectious Diseases Training Program Journal Club LCME M.D./Ph.D ... Microbiology, Immunology and infectious Diseases Graduate Program Microbiology, Immunology, and Cancer Biology Molecular Cell ...
Peripheral Nervous System Diseases Medicine & Life Sciences 100% * Drug Therapy Medicine & Life Sciences 55% ... Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting toxicity, negatively affecting both quality of ... N2 - Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting toxicity, negatively affecting both ... AB - Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting toxicity, negatively affecting both ...
... the precise mechanism inducing dysmylination in NPC1 disease is still unclear. In the present study, a quantitative evaluation ... Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting in a neurodegenerative ... and histopathologic changes confirm peripheral nervous system myelin abnormalities in the feline model of niemann-pick disease ... Metabolic Brain Disease. Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting ...
This is supposed to be an autoimmune disease of the peripheral nervous system. Would taking this help or hurt my condition ... Maximized immune system: The primary vehicle the immune system uses for destroying invaders is enzymes. Macrophages, for ... What they do is, by removing circulating immune complexes, take load off the immune system so that your immune system can work ... At first, these CICs may be neutralized by the immune system, then eliminated through the lymphatic system and the kidneys. ...
New research indicates that inflammation plays a causal role in the array of neurologic changes associated with Lyme disease, ... of patients with Lyme disease develop peripheral and central nervous system involvement, often accompanied by debilitating and ... About 15% of patients with Lyme disease develop peripheral and central nervous system involvement, often accompanied by ... only when lymphocytic inflammatory lesions were also observed in both the central nervous system and peripheral nervous system ...
Chronic carbon-disulfide exposure resulted in central and peripheral nervous system dysfunction, gastrointestinal changes, ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... cardiovascular disease, and mental illness. Studies have shown that workers exposed to carbon- disulfide show frequent ...
MS is a disease of the central nervous system. This includes the brain and spinal cord. GBS is a disease of the peripheral ... since damaged myelin of the peripheral nervous system regenerates more effectively than that of the central nervous system. The ... nervous system (the nerves outside the brain and spinal cord). MS does not cause a sudden and catastrophic paralysis of the ... How can we propagate this to the general public that we have a better system available to treat COVID. What is use of having a ...
... of which the R220Pfs*23 carrier also had neurologic manifestations in the central nervous system. We then constructed GJB1 ... All 4 probands presented typical early-onset peripheral neuropathy, of which the R220Pfs*23 carrier also had neurologic ... manifestations in the central nervous system. We then constructed GJB1 expression vectors and performed cell biological ... All four probands presented typical early-onset peripheral neuropathy, ...
This Institute studies all the scientific and medical fields to do with the central and peripheral nervous system, its ... The economic impact of these diseases accounts for a third of the human cost of diseases in Europe. ... plasticity and aging of the nervous system. Genes interact with the environment at every stage when the functional nervous ... Progress in our knowledge of the symptoms and causes of nervous system disorders has enabled us to determine their extent and ...
Peripheral and Central Nervous System Implications in Celiac Disease Women in Digestive Diseases: At the Forefront 2022 ... Peripheral and Central Nervous System Implications in Celiac Disease. Saturday, November 20, 2021 8:30 AM - 1 PM None ... 2022 Safadi Lecture: Emerging Gene Therapies for the Central Nervous System. Thursday, August 18, 2022 11 AM - 1 PM 900 E 57th ... Videos Updates in IBD and Annual Updates in Digestive Diseases Neurological and Psychological Implications in Celiac Disease ...
... is a genetically heterogeneous hereditary peripheral neuropathy. Brain volumetry and diffusion tensor imaging (DTI) were ... Transient central nervous system white matter abnormality in X-linked Charcot-Marie-Tooth disease. Ann. Neurol. 2002, 52, 429- ... a disorder affecting the central and peripheral nervous systems. Cell Tissue Res. 2015, 360, 659-673. [Google Scholar] [ ... However, the central nervous system (CNS) has been implicated in several CMT patients with GJB1 and MFN2 mutations [4,5], and ...
Chronic exposure may result in poisoning of the nervous system, liver damage, and peripheral vascular disease, which could ... Agency for Toxic Substance and Disease Registration. Agency for Toxic Substance and Disease Registration. ... Organochloride insecticides affect the peripheral nervous system (PNS) through dermal absorption, inhalation, and ingestion. ... Methyl mercury is the most toxicological form of the element and, by its accumulation in the central nervous system (CNS), may ...
  • Charcot-Marie-Tooth Disease (CMT), also known as hereditary motor sensory neuropathy (HMSN), was first reported by French neurologists Charcot and Marie and British neurologist Tooth in 1886 [ 1 , 2 ]. (hindawi.com)
  • Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting toxicity, negatively affecting both quality of life and disease outcomes. (elsevier.com)
  • Some patients with Lyme disease also show evidence of demyelinating neuropathy and slowing nerve conduction. (news-medical.net)
  • X-linked Charcot-Marie-Tooth Disease type 1(CMT1X) is the second most common form of inherited peripheral neuropathy that is caused by mutations in the gap junction beta-1 (GJB1) gene. (frontiersin.org)
  • All four probands presented typical early-onset peripheral neuropathy, of which the R220Pfs * 23 carrier also had neurologic manifestations in the central nervous system. (frontiersin.org)
  • Aims/hypothesis: The aim of this study was to evaluate the effects on diabetic peripheral neuropathy (DPN) of a long-term intensive lifestyle intervention (ILI) programme designed to achieve and maintain weight loss. (elsevier.com)
  • Comorbidities for peripheral neuropathy were excluded. (biomedcentral.com)
  • These results confirm the role of peripheral neuropathy in Gaucher pain and demonstrate that skin denervation is as a constitutive feature of the disorder. (biomedcentral.com)
  • showed a high prevalence of peripheral neuropathy (16.5%) in a cohort of GD1 patients followed for 2 years [ 9 ]. (biomedcentral.com)
  • Serial electrophysiological and immunological findings showed that diabetes was involved in the immune-mediated mechanism of peripheral neuropathy. (elsevier.com)
  • GJB1 disorders are typically characterized by peripheral motor and sensory neuropathy with or without fixed CNS abnormalities and/or acute, self-limited episodes of transient neurologic dysfunction (especially weakness and dysarthria). (nih.gov)
  • Peripheral neuropathy typically manifests in affected males between ages five and 25 years. (nih.gov)
  • GJB1 Charcot-Marie-Tooth neuropathy with or without central nervous system dysfunction (CMT1X) should be suspected in an individual with the following clinical findings, electrophysiologic findings, and family history. (nih.gov)
  • Disease or damage involving the SCIATIC NERVE , which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY ). (nih.gov)
  • Acute peripheral nervous system involvement associated with Lyme disease includes radiculopathy, cranial neuropathy (Bell palsy, Figure 5 ), and mononeuropathy multiplex. (cfp.ca)
  • Neurologic symptoms of late Lyme disease can include encephalomyelitis, peripheral neuropathy, or encephalopathy. (cfp.ca)
  • It is associated with many diseases, including diabetic peripheral neuropathy, postherpetic neuralgia, human immunodeficiency virus-related disorders, and chronic radiculopathy. (mayoclinicproceedings.org)
  • Have you ever heard of diabetic peripheral neuropathy? (nomonausea.com)
  • A basic peripheral neuropathy workup is recommended in cases in which the diagnosis is uncertain. (medscape.com)
  • Neuropathy refers to pain and miscommunication between the central nervous system and the rest of your body. (alleviatepain.com)
  • Peripheral neuropathy occurs when the nerves of the extremities, such as the legs, hands, and feet, are affected. (alleviatepain.com)
  • When something happens to the nerves of your involuntary nervous system, which controls circulation and the heart, as well as digestion and bladder function, you have autonomic neuropathy. (alleviatepain.com)
  • Peripheral nerve disorders happen when one or more peripheral nerves are damaged. (medlineplus.gov)
  • Peripheral nerve disorders are very common. (medlineplus.gov)
  • Diabetes is the most common cause of peripheral nerve disorders. (medlineplus.gov)
  • Some examples of peripheral nerve disorders from physical injury include complex regional pain syndrome and brachial plexus injuries . (medlineplus.gov)
  • What are the symptoms of peripheral nerve disorders? (medlineplus.gov)
  • How are peripheral nerve disorders diagnosed? (medlineplus.gov)
  • Can peripheral nerve disorders be prevented? (medlineplus.gov)
  • Like many other degenerative disorders, hereditary peripheral neuropathies have been difficult to treat. (hindawi.com)
  • This graduate course uses a multidisciplinary approach to integrate the basic with the clinical neurosciences in understanding the human nervous system and select neurological disorders. (iu.edu)
  • Charcot-Marie-Tooth (CMT) disease is a genetically heterogeneous group of disorders characterized by progressive distal muscle weakness and atrophy, usually with foot deformities and sensory loss, as well as decreased tendon reflexes ( Szigeti and Lupski, 2009 ). (frontiersin.org)
  • Progress in our knowledge of the symptoms and causes of nervous system disorders has enabled us to determine their extent and frequency better. (aviesan.fr)
  • These conditions can be inherited in autosomal dominant, autosomal recessive, and X-linked patterns, and each group of disorders exhibits variable clinical presentation, age of onset, degree of severity, and disease progression. (ggc.org)
  • One can see a neurosurgeon if you have any symptoms like birth-defects, trauma to brain or spine due to some shock or accident, brain tumours, vascular disorders, infections in the brain or spine, stroke, or degenerative diseases of the spine like multiple sclerosis. (practo.com)
  • Surgeons who are specialized in examining, diagnosing, and treating diseases and disorders related to the nervous system through medications and surgeries are called Neurosurgeons. (practo.com)
  • Both Neurosurgeons and Neurologists are medical doctors who are specialized and well trained in Neurology and treat patients who are suffering from nervous system disorders. (practo.com)
  • We provide to our customers our in depth know-how in the evaluation of treatment for neurodegenerative diseases and neurological disorders. (neurofit.com)
  • Otolaryngologists are physicians trained in the medical and surgical management and treatment of patients with diseases and disorders of the ear, nose, throat (ENT), and related structures of the head and neck. (ac.ir)
  • Neurology is a branch of medicine dealing with disorders of the nervous system. (ac.ir)
  • Neurosurgery (or Neurological Surgery) is the medical specialty concerned with the prevention, diagnosis, treatment, and rehabilitation of disorders which affect any portion of the nervous system including the brain, spinal cord, peripheral nerves, and extra-cranial cerebrovascular system. (ac.ir)
  • Neurologist in Multan - Neurology is the branch of medical sciences that deals with the disease, disorders of the nervous system. (hamariweb.com)
  • He treats the disorders and diseases that affect the brain, spinal cord, and nerves, such as: strokes or Cerebrovascular disease, Demyelinating diseases, Headache disorders, Infections of the brain and peripheral nervous system, Movement disorders, Speech disorders, Neurodegenerative disorders are all included in the treatment domain of Neurologist. (hamariweb.com)
  • Definition of neurology: a science involved in the study of the nervous systems, especially of the diseases and disorders affecting them. (neurosciencenews.com)
  • Parkinson's disease (PD) is a neurodegenerative disorder, affectingmotor and non-motor functions of the central and peripheral nervous systems, including the dopaminergic neurons of the substantia nigra.The incidence of PD is one of the highest among all neurological disorders. (neuramedy.com)
  • The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. (weedworldmagazine.org)
  • In this way you are preventing disorders with your nervous system which means that you are preventing the burning feet in your feet. (instiks.com)
  • What are peripheral nerves? (medlineplus.gov)
  • Your peripheral nerves branch off from your brain and spinal cord and connect to all parts of your body, including your muscles and organs. (medlineplus.gov)
  • The areas most commonly affected by leprosy are the superficial peripheral nerves, skin, mucous membranes of the upper respiratory tract, anterior chamber of the eyes, and the testes. (medscape.com)
  • For Schwann cells in particular, the mycobacteria bind to the G domain of the alpha-chain of laminin 2 (found only in peripheral nerves) in the basal lamina, causing demyelination. (medscape.com)
  • The pathology found in the dorsal root ganglia and sensory nerves may explain the localized pain and motor deficits that Lyme disease patients experience close to the origin of the tick bite. (news-medical.net)
  • Histopathologic findings consist of degeneration of myelinated fibers in peripheral nerves and chromatolysis and loss of sensory neurons in spinal ganglia. (msdvetmanual.com)
  • Peripheral nerves control sensory, motor and autonomic functions and can regenerate though very slowly. (uctv.tv)
  • A logical approach to the treatment of cerebral lupus is to build a treatment strategy around the various possible pathogeneses: (1) ischemia due to thromboses secondary to the antiphospholipid syndrome, (2) small-vessel noninflammatory proliferative vasculopathy due to cell-mediated immune mechanisms, and (3) antibody-mediated damage to the spinal cord and optic nerve-akin to Devic disease. (medscape.com)
  • Central nervous system involvement includes lymphocytic meningitis and, rarely, encephalomyelitis (parenchymal inflammation of brain or spinal cord, with focal abnormalities). (cfp.ca)
  • Spinal muscular atrophy (SMA) is a rare genetic disease affecting the central nervous system, peripheral nervous system and voluntary muscle movement. (nm.org)
  • A neurosurgeon is a doctor with a specialization in diagnosis and treatment of brain, spinal cord and nerve-related diseases. (practo.com)
  • No, a neurologist cannot treat birth-defects in the nervous system, but a neurosurgeon can operate on such defects present since birth in the brain and spinal cord in infants and children. (practo.com)
  • In other cases of ADEM, modest visual or motor deficits may persist, as may sphincter abnormalities in patients with spinal cord disease. (medscape.com)
  • CB1 receptors, which are mostly concentrated in the central nervous system - your brain and spinal cord and mostly in areas of the central nervous system that have to do with processing pain messages from the body[12].CB2 receptors, which are more evenly distributed throughout the body and are especially prevalent in the immune system[12]. (siciley.com)
  • In its early years, the Institute's staff focused on dealing with long-term effects and complications of injuries of the skull, brain and spinal cord, the peripheral and in particular autonomic nervous system. (kiev.ua)
  • One of the most significant and complex network of the body nervous system deals with the brain and spinal cord. (hamariweb.com)
  • 2016). A DYNC1H1 mutation in autosomal dominant spinal muscular atrophy shows the potential of pharmacological inhibition of histone deacetylase 6 as a treatment for disease associated cellular phenotypes . (city.ac.uk)
  • it is occasionally used for repairing damaged peripheral joints and rarely used to correct spinal deformities as it involves significant morbidity. (medscape.com)
  • The leukemia cells can spread outside the blood to other parts of the body, including the central nervous system (brain and spinal cord ), skin, and gums . (cancer.gov)
  • Stroke (brain hemorrhage/infarction), Diseases of arteries and veins of the brain and spinal cord, brain tumors. (neurocitihospital.com)
  • Hereditary neuropathies, including Charcot-Marie-Tooth disease, affect the peripheral nervous system and include symptoms of muscle weakness, decreased reflexes, foot deformities, and loss of sensation. (ggc.org)
  • Your genes , including changes in your genes or conditions that you inherit from your parents, such as Charcot-Marie-Tooth disease . (medlineplus.gov)
  • Charcot-Marie-Tooth Disease (CMT) is the most common clinical genetic disease of the peripheral nervous system. (hindawi.com)
  • The Dear Medical Professional Letter has a brief description of Charcot-Marie-Tooth disease and the neurotoxic drug list. (cmtausa.org)
  • Journal of the Peripheral Nervous System , 9 (2), 92-97. (elsevier.com)
  • Scaioli, V , Andreetta, F & Mantegazza, R 2004, ' Unusual neurophysiological and immunological findings in myasthenia gravis: A case report ', Journal of the Peripheral Nervous System , vol. 9, no. 2, pp. 92-97. (elsevier.com)
  • Journal Of The Peripheral Nervous System , 21(3), pp. 261-262. (city.ac.uk)
  • A pronounced neurodegeneration and glia activation in the olfactory system of NPC1−/− animals is demonstrated, accompanied by sensory deficits, which underlines the critical role and location of the OB as a possible entrance gate for noxious substances. (semanticscholar.org)
  • Clinical symptoms of LNB of the peripheral nervous system may include facial nerve palsy, neurogenic pain radiating along the back into the legs and feet, limb pain, sensory loss, or muscle weakness. (news-medical.net)
  • Specifically, our work has demonstrated that there is a complex interplay between immune responses and sensory pathways and that chronic pain following nervous system damage results from a neuroimmune imbalance leading to chronic neuroinflammation and long-lasting neuropathic pain. (edu.au)
  • The peripheral nervous system includes sensory receptors. (hamariweb.com)
  • The control of balance requires the integration of information from multiple sensory and motor systems by the central nervous system (CNS). (cdc.gov)
  • Because the balance system is so complex, it can be impaired by a large number of disease processes affecting any of the multiple sensory inputs, neural processing centers, or motor outputs. (cdc.gov)
  • it is the sensory system that provides the dominant input about movement and sense of balance. (medicalsymptomsguide.com)
  • Treatment for symptoms depends on the type of peripheral nerve disorder you have, where it is, and how severe. (medlineplus.gov)
  • Less threatening flare-ups may be treated with as much as 100 mg or as little as 10 mg prednisone orally (PO) daily (QD) (or other agents in equivalent dosage), again tapering gradually according to clinical symptoms, with an increase of 10-20% during the taper if clinical disease flares again. (medscape.com)
  • Inflammation, which can cause tissue and organ damage, is the main trigger behind the symptoms of autoimmune diseases . (verywellhealth.com)
  • These signs and symptoms are common to most autoimmune diseases. (verywellhealth.com)
  • About 15% of patients with Lyme disease develop peripheral and central nervous system involvement, often accompanied by debilitating and painful symptoms. (news-medical.net)
  • Pain is one of the most disabling symptoms of Gaucher disease. (biomedcentral.com)
  • Sometimes called Kugelberg-Welander disease, the most common symptoms of this type of SMA include clumsiness, trouble walking and climbing steps, fine tremor and muscle weakness. (nm.org)
  • In endemic areas, the disease should be ruled out in all patients who develop unexplained neurological symptoms. (who.int)
  • As with any chronic disease, patient education is vital to familiarize the patient with the symptoms, course, and treatment of the disease. (medscape.com)
  • Regular exercise helps reduce the symptoms and may slow the progress of the disease. (medscape.com)
  • Typically the diagnosis of valvular disease and dysfunction has been previously established but emergency physicians must be alert to the presenting signs and symptoms to aid the undiagnosed patient, and with bedside echocardiography becoming more common, initial diagnosis will occur more commonly in the ED. (mhmedical.com)
  • Also, partial presentations (an absence of some of the following signs/symptoms) do not necessarily imply less severe disease. (cdc.gov)
  • Symptoms of the disease include periodic episodes of rotary vertigo or dizziness. (medicalsymptomsguide.com)
  • Symptoms caused by mercury, such as general fatigue may be caused by many disease states so dental fillings are rarely suspected. (sohointegrativemedicine.com)
  • Chronic carbon - disulfide exposure resulted in central and peripheral nervous system dysfunction, gastrointestinal changes, cardiovascular disease, and mental illness. (cdc.gov)
  • Myopathies are associated with weakness and dysfunction of predominantly proximal skeletal muscles, and wasting may occur in later stages of disease. (ggc.org)
  • Neuropathic pain (NP), caused by a primary lesion or dysfunction in the nervous system, affects approximately 4 million people in the United States each year. (mayoclinicproceedings.org)
  • β-amyloid i.c.v injection induces learning deficits and a dysfunction of the cholinergic system. (neurofit.com)
  • Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting in a neurodegenerative process in patients mainly at an early age, although some patients may start with manifestation in adult. (semanticscholar.org)
  • In neurodegenerative diseases, stroke, and infection, NETs in human blood samples has been found to be positively or negatively associated with clinical outcome [ 16 - 18 ]. (aging-us.com)
  • Alzheimer's disease is the most common age-related neurodegenerative disorder, characterized by the progressive degeneration of neuronal populations and the simultaneous loss of memory and cognitive functions. (neurofit.com)
  • Alpha Cognition Inc. is a clinical stage, biopharmaceutical company dedicated to developing treatments for under-served neurodegenerative diseases, such as Alzheimer's Dementia and Amyotrophic Lateral Sclerosis (ALS). (alphacognition.com)
  • Its use for the treatment of neurodegenerative diseases has been patented by the Company and granted an Orphan Drug Designation. (alphacognition.com)
  • 3) 'Encephalopathy and polyneuropathy are the most common diseases related to neurology following the exposure to low levels of environmental substances. (harvoa.org)
  • Repair and rebuild the cardiovascular system. (jonbarron.org)
  • According to the results of questionnaire and electrocardiogram, all subjects were free of hypertension, hyperlipemia, cardiovascular disease, and diabetes mellitus. (hindawi.com)
  • In addition to renal disease, cardiovascular effects, and reproductive toxicity, lead may cause irreversible neurologic damage. (cdc.gov)
  • 150/90 mmHg), significant cardiovascular impairment or event within previous 12 months or patients who had active autoimmune disease or a medical condition that required immunosuppression. (merck.com)
  • Our Neurology series is designed for the practitioner managing conditions and disease of the central and peripheral nervous systems. (audio-digest.org)
  • She writes across the biomedical sciences, but holds strong interests in rheumatology, neurology, autoimmune diseases, genetics, and the intersection of broader social, cultural and emotional contexts with biomedical topics. (the-rheumatologist.org)
  • Best Neurology Treatment in Ludhiana, Punjab, A neurologist is a medical expert who specializes in checking, diagnosing, and treating nervous system problems. (neurocitihospital.com)
  • Clinical studies supporting this approach were generally performed in lupus nephritis because of its frequency, severity, and quantifiable improvement or deterioration, still, the same treatment approaches are generally applied to other organ systems, including the central and peripheral nervous systems and muscular disease. (medscape.com)
  • Tapering to an every-other-day steroid regimen reduces adverse effects substantially but probably will not be successful until the clinical disease is relatively stable. (medscape.com)
  • Modulation of the immune system via B-cell depletion is entering clinical practice. (medscape.com)
  • It is the most common clinical single-gene genetic disease of the peripheral nervous system with high clinical heterogeneity and genetic heterogeneity, with a prevalence of about 1/2500 [ 3 , 4 ]. (hindawi.com)
  • Although this classification helps in describing disease progression and prognosis, studies of GD clinical history showed the existence of a continuum of phenotypes, ranging from the severe GD2 to the asymptomatic GD1 form [ 3 ]. (biomedcentral.com)
  • Therefore, we proposed a hypothesize that peripheral neutrophils probably elevated after SAH and the elevation of neutrophils count perhaps associated with unfavorable SAH clinical outcome. (aging-us.com)
  • We reviewed the clinical manifestations and outcome of 20 cases of neurobrocellosis out of 1375 patients with brucellosis admitted to the infectious diseases ward of a tertiary hospital in Hamedan, Islamic Republic of Iran. (who.int)
  • In modern clinical practice, physicians personally assess patients in order to diagnose, prognose , treat, and prevent disease using clinical judgment. (owiki.org)
  • While rates of endometrial carcinoma continue to rise globally, patients with advanced or recurrent disease have limited options available to them once the disease progresses following platinum-based chemotherapy," said Dr. Gregory Lubiniecki, Vice President, Oncology Clinical Research, Merck Research Laboratories. (merck.com)
  • A condition referred to as "chronic Lyme disease" has been suggested by a small number of medical practitioners, but its existence is viewed with scepticism by the mainstream medical community. (cfp.ca)
  • Leprosy is a chronic granulomatous disease principally affecting the skin and peripheral nervous system. (medscape.com)
  • Despite this discovery, leprosy was not initially thought to be an infectious disease. (medscape.com)
  • Leprosy is included among the Neglected Tropical Diseases as designated by the World Health Organization. (medscape.com)
  • Leprosy is not a highly infectious disease. (medscape.com)
  • Leprosy is not generally spread by means of direct contact through intact skin, although the most vulnerable are close contacts of patients with untreated multibacillary disease. (medscape.com)
  • However, the diagnosis of SS with neurologic involvement is sometimes difficult, and central nervous system (CNS) manifestations have been described rarely. (lww.com)
  • Molecular testing is useful to confirm the diagnosis and to identify the disease causing mutations within a family to allow for carrier testing and prenatal diagnosis. (ggc.org)
  • In the context of significant weight loss, serum creatinine levels may overestimate eGFR, leading to a delayed diagnosis of chronic kidney disease (CKD) and late referral to a specialist. (medscape.com)
  • The field includes medical diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular heart disease and electrophysiology. (ac.ir)
  • Internal Medicine or General Medicine is the medical specialty dealing with the prevention, diagnosis, and treatment of adult diseases. (ac.ir)
  • Medicine is the science and practice of establishing the diagnosis , prognosis , treatment , and prevention of disease . (owiki.org)
  • Medicine is the science and practice of the diagnosis, prognosis, treatment, and prevention of disease. (owiki.org)
  • The invention also includes the use of these cells for the treatment of neurological conditions such as Parkinson's disease. (justia.com)
  • A condition where damage to the peripheral nervous system (including the peripheral elements of the autonomic nervous system) is associated with chronic ingestion of alcoholic beverages. (umassmed.edu)
  • The disease mimicked relapsing-remitting multiple sclerosis (MS) in 10 patients and primary progressive MS in 13 patients. (lww.com)
  • Lewy body (ies) (disease) (G31.8) · multiple sclerosis (G35) · neurosyphilis (A52.1) · niacin deficiency [pellagra] (E52) · polyarteritis nodosa (M30.0) · systemic lupus erythematosus (M32. (who.int)
  • A type of glial cell of the peripheral nervous system that helps separate and insulate nerve cells called Schwann cells may cause the tumor as a result of overproduction. (medicalsymptomsguide.com)
  • AL amyloidosis often occurs in persons with monoclonal gammopathy and typically affects the heart and kidneys, although the peripheral and autonomic nervous systems, gastrointestinal tract, and other organs may be involved. (medscape.com)
  • The purpose of this study was to examine the effects of moderate intensity interval training from the change of the autonomic nervous activity. (hindawi.com)
  • It is clarified that the exercise as well as activating the vagus nerve activity stimulates the total autonomic nervous activity. (hindawi.com)
  • Autonomic nervous activity decreases with age. (hindawi.com)
  • it shows the imbalance of the autonomic nervous activity. (hindawi.com)
  • For keeping people healthy, it is necessary to find an exercise to suppress the sympathetic activity and to increase the autonomic nervous activity especially vagus nerve activity. (hindawi.com)
  • Then, we demonstrate the effectiveness of this training from the change of the autonomic nervous activity by moderate intensity interval training in an index of the heart rate. (hindawi.com)
  • Our research is focused on neuropathic pain, a particularly debilitating form of chronic pain caused by a lesion or disease affecting the somatosensory nervous system. (edu.au)
  • Infections , such as HIV and Lyme disease . (medlineplus.gov)
  • Infections of patients with this bacterium manifests as the disease cholera. (sens.org)
  • AA amyloidosis affects persons with chronic infections or autoinflammatory diseases and primarily involves the kidneys. (medscape.com)
  • Autoimmune diseases , such as rheumatoid arthritis and lupus . (medlineplus.gov)
  • Alopecia areata is a condition in which the immune system attacks the hair follicles, causing hair loss. (verywellhealth.com)
  • Antiphospholipid syndrome (APS) is a condition in which antibodies -proteins produced by the immune system-damage the cells lining the blood vessels. (verywellhealth.com)
  • Celiac disease occurs when the immune system attacks the lining of the small intestines in response to gluten , a protein found in wheat, rye, barley, and many prepared foods. (verywellhealth.com)
  • Clean up your immune system. (jonbarron.org)
  • The vast majority of metabolic enzymes in your body, the enzymes that regulate everything from liver function to the immune system, are proteases, or proteolytic enzymes. (jonbarron.org)
  • The principal aim of our research is to understand the relationship between the nervous system and the immune system, with particular emphasis on how immune cells and their mediators affect neuropathic pain, and to assess immunotherapeutic approaches. (edu.au)
  • When the immune system detects toxic inorganic metals in body tissues, it sees these as "foreign" and proceeds to destroy them, turning on its own tissues, hence the term "autoimmune. (sohointegrativemedicine.com)
  • It has been mainly considered as nociceptive pain secondary to skeletal involvement but it is described even in the absence of bone disease without a clear explanation. (biomedcentral.com)
  • Cardiac involvement associated with Lyme disease includes intermittent atrioventricular heart block, often involving the atrioventricular node (although heart block can occur at multiple levels), and sometimes myopericarditis. (cfp.ca)
  • Fifty-one patients had peripheral nervous system involvement (PNS). (lww.com)
  • At least 36 proteins have been identified in humans, with 17 showing systemic involvement and the rest presenting as localized diseases. (medscape.com)
  • In case of peripheral lesion, it is the anal tone and the contraction that varied the symptomatology. (bvsalud.org)
  • Dr. Kaposi's work is also interesting in the context of the current challenge of classifying patients with complex and overlapping multisystem autoimmune diseases. (the-rheumatologist.org)
  • There is growing evidence that the effects of amalgam in a person's teeth could contribute to autoimmune diseases. (sohointegrativemedicine.com)
  • Also there are other causes which are not so common as the previously mentioned causes, but also there are people who have burning feet caused by chronic kidney disease, injuries, stings and bites from insects, deficiencies of calcium, B vitamins, thiamine and folic acid, peripheral vascular disease, burning feet syndrome and traumas. (instiks.com)
  • Genes interact with the environment at every stage when the functional nervous system is forming and contributes to its plasticity over time. (aviesan.fr)
  • This panel consists of 144 genes that have been associated with inherited neuromuscular diseases. (ggc.org)
  • Our group studies genetic diseases that confer a high predisposition to develop cancer. (germanstrias.org)
  • The biological function enrichment analysis suggested that myelin sheath, axon, peripheral nervous system, mitochondrial function, various metabolic processes, and autophagy played important roles in CMT development. (hindawi.com)
  • In certain cases, the cause of peripheral nerve disorder is not known. (medlineplus.gov)
  • The advent of next-generation sequencing (NGS) has expanded and accelerated the analysis of various diseases at the level of genome, especially in heterogeneous disorder groups such as CMT [ 9 , 10 ]. (hindawi.com)
  • This effort was driven by the memory of their son, Greyson , who died of Krabbe disease, a rare inherited degenerative disorder of the central and peripheral nervous systems. (susannahfox.com)
  • Vertigo is usually caused by a disorder in the central or peripheral vestibular system. (medicalsymptomsguide.com)
  • Meniere's disease is a disorder of the inner ear that can cause affect hearing and balance. (medicalsymptomsguide.com)
  • It is being developed as a new generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease, with minimal gastrointestinal side effects and novel routes of administration. (alphacognition.com)
  • Control of brain and nerve diseases : a world-wide challenge. (who.int)
  • This program discusses peripheral nerve diseases, including the anatomy of the central and peripheral nervous systems by Dr. Maggie Waung. (uctv.tv)
  • On successful completion of this module you will be able to describe the structure and functions of the auditory, visual, and central and peripheral nervous system and outline pathophysiology of common diseases of these systems. (mdx.ac.uk)
  • We could not elucidate pathophysiology of systemic diseases like lupus without first looking for commonalities and distinctions among patients," says Dr. Salmon. (the-rheumatologist.org)
  • Since loss of myelin is considered as a main pathogenetic factor, the precise mechanism inducing dysmylination in NPC1 disease is still unclear. (semanticscholar.org)
  • GJB1- encoded GJB1 protein, also named connexin-32 (Cx32), is widely expressed in peripheral myelin and is specifically located at uncompacted folds of Schwann cell cytoplasm around the nodes of Ranvier and Schmidt-Lanterman incisures ( Abrams and Freidin, 2015 ). (frontiersin.org)
  • Graduate-level neuroscience course providing an introduction to terminology, pathways, organization and current research-based concepts of the human nervous system. (iu.edu)
  • I have long known my future career will lie somewhere in the field of Neuroscience, but only due to my internship last summer did I realize my passion lies in research and development of therapeutics for neurological diseases. (sens.org)
  • However, differentiation to a specific neural cell population is required to realize many of the potential applications of ES cells in regenerative medicine of the central nervous system and neuroscience. (justia.com)
  • Neuroscience is the scientific study of nervous systems. (neurosciencenews.com)
  • Few of the central and peripheral nervous system diseases are seizures, brain stroke, epilepsy, Alzheimer's disease, and myasthenia gravis. (practo.com)
  • MCI is known as a risk factor for Alzheimer's disease and dementia. (neurofit.com)
  • Crohn's disease is an inflammatory bowel disease that causes widespread digestive tract inflammation. (verywellhealth.com)
  • New research indicates that inflammation plays a causal role in the array of neurologic changes associated with Lyme disease, according to a study published in The American Journal of Pathology . (news-medical.net)
  • The researchers examined the role of inflammation in the nervous systems of Bb-infected animals. (news-medical.net)
  • 11 A brain disease that is characterized by inflammation of the brain tissue occurring as a result of an underlying condition. (malacards.org)
  • Evidence indicates that neutrophil has promoted inflammation in several central nervous system diseases. (aging-us.com)
  • To identify a mechanistic pathway that may clarify the relationship between blood neutrophil count and neurological outcomes, we studied the role of NETs on microglia, which is the fundamental effector cells for inflammation response in the central nervous system [ 26 , 27 ]. (aging-us.com)
  • AA amyloidosis is another form of acquired systemic disease that results from high levels of serum AA protein, an acute phase reactant associated with chronic inflammation. (medscape.com)
  • Among its many beneficial health effects CBD has been shown to reduce pain and inflammation, alleviate anxiety, protect the nervous system, and prevent seizures[2-4]. (siciley.com)
  • however, patients with coexisting diseases, such as inflammatory bowel disease (IBD), have dietary restrictions. (medscape.com)
  • Basic Anatomy of the Balance System. (cdc.gov)
  • Intensity and quality of pain were recorded by Douleur Neuropathique en 4 questionnaire and Neuropathic Pain Symptom Inventory. (biomedcentral.com)
  • As with all valvular diseases, exertional dyspnea is the most common presenting symptom (80% of patients with mitral stenosis). (mhmedical.com)
  • Vertigo is described as a symptom, it is not a disease. (medicalsymptomsguide.com)
  • It affects the eyes and the skin as well as the upper respiratory system, and is able to penetrate the lungs during mouth breathing as opposed to nose breathing. (cdc.gov)
  • Chronic inflammatory demyelinating polyradiculoneuropathy is a rare and chronic autoimmune disease that affects the peripheral nervous system. (takeda.com)
  • 6) 'Some aspects of the mechanism of action of atmospheric pollutants (acetone, benzene, ammonia, formaldehyde, and ozone) on the central nervous system were studied by using methods of functional electroencephalography (analysis of the readjustment reaction to a rhythmic light stimulus, evoked potentials of the cerebral cortex, and determination of the photometrazol thresholds). (harvoa.org)
  • Systemic emboli may occur and result in myocardial, kidney, central nervous system, or peripheral infarction. (mhmedical.com)
  • Departments of neurooncology, acute injury of the central and peripheral nervous system, neuro-vascular pathology, restorative neurosurgery and pediatric neurosurgery were created. (kiev.ua)
  • While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. (dealpain.net)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Neurological diseases range from Alzheimer's and other dementias to stroke and brain cancer . (labiotech.eu)
  • Diabetes can also increase the risk of heart disease, stroke, kidney disease, vision problems, and nervous system issues. (nomonausea.com)
  • Disease of the brain. (studystack.com)
  • Transplantation experiments have demonstrated the potential of mouse ES derived neural cells to participate in brain development and to correct various deficits in animal model systems. (justia.com)
  • Many neurological diseases affect multiple regions of the brain and many cell types. (labiotech.eu)
  • CBD acts on your brain and body through a network of receptors called the endocannabinoid system (ECS). (siciley.com)
  • Cannabinoids and their receptors throughout the brain and body form an interconnected network called the endocannabinoid system (ECS). (siciley.com)
  • Chemokines such as IL-8 and CCL2 are known to mediate the influx of immune cells in the central nervous system compartment during bacterial meningitis, and CXCL13 is the major determinant of B cell recruitment into the cerebrospinal fluid during neuroinflammation,' explained Dr. Philipp. (news-medical.net)
  • Although many studies have focused on elucidating the pathogenesis of CMT, few focuses on achieving a systematic analysis of biology to decode the underlying pathological molecular mechanisms and the mechanism of its disease remains to be elucidated. (hindawi.com)
  • Emphasis on fundamental knowledge of the structure, neurochemistry and molecular mechanisms of the central and peripheral nervous systems in health and disease. (iu.edu)
  • She also emphasizes the importance of Kaposi's contribution in recognizing SLE as a systemic disease, because that enabled the search for underlying mechanisms. (the-rheumatologist.org)
  • The following aspects were analyzed among the proposed mechanisms: changes in the occlusion and condylar position, increase in the vertical dimension, change of the peripheral impulse to the central nervous system, natural regression to the mean, placebo effect and individual's cognitive awareness. (bvsalud.org)