Central Nervous System Diseases
Peripheral Nervous System Diseases
Peripheral Nervous System
The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
Nervous System Diseases
Central Nervous System Viral Diseases
Meningoencephalitis
Central Nervous System Infections
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
Central Nervous System
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Subacute Sclerosing Panencephalitis
A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
AIDS Dementia Complex
A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
Brain Diseases
Demyelinating Diseases
Maus Elberfeld virus
Peripheral Nerves
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
Cerebrospinal Fluid
Meninges
Nervous System
Neurons
Astrocytes
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Schwann Cells
Sciatic Nerve
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Disease Models, Animal
Myelin Sheath
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
Magnetic Resonance Imaging
Cells, Cultured
Peripheral Nervous System Neoplasms
Ganglia, Spinal
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
Autonomic Nervous System Diseases
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
Lamin Type A
Enteric Nervous System
Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)
Neural Crest
The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.
Immunohistochemistry
Spinal Cord
Digestive System Diseases
Neuroglia
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Nervous System Physiological Phenomena
Myelin P0 Protein
A protein that accounts for more than half of the peripheral nervous system myelin protein. The extracellular domain of this protein is believed to engage in adhesive interactions and thus hold the myelin membrane compact. It can behave as a homophilic adhesion molecule through interactions with its extracellular domains. (From J Cell Biol 1994;126(4):1089-97)
Mutation
In Situ Hybridization
Neural Conduction
Gene Expression Regulation, Developmental
Charcot-Marie-Tooth Disease
A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)
Myelin Proteins
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Cause of Death
Wallerian Degeneration
Neuritis, Autoimmune, Experimental
An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
Autonomic Nervous System
The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.
Ranvier's Nodes
Central Nervous System Neoplasms
SOXE Transcription Factors
Sympathetic Nervous System
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Trauma, Nervous System
Heart Conduction System
Nervous System Neoplasms
Drosophila
Cell Differentiation
Drosophila Proteins
Polyneuropathies
Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
Neurofilament Proteins
Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Ganglia, Sympathetic
Nerve Growth Factors
Immune System Diseases
Cranial Nerves
Sensory Receptor Cells
Sural Nerve
Amino Acid Sequence
Endocrine System Diseases
Mice, Transgenic
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Base Sequence
Chick Embryo
Embryo, Nonmammalian
Peripheral Nervous System Agents
Peripheral Vascular Diseases
Rats, Sprague-Dawley
Ganglia
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Gene Expression
Oligodendroglia
A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.
Risk Factors
Early Growth Response Protein 2
Phenotype
Neuropeptides
Transcription Factors
Neurites
In tissue culture, hairlike projections of neurons stimulated by growth factors and other molecules. These projections may go on to form a branched tree of dendrites or a single axon or they may be reabsorbed at a later stage of development. "Neurite" may refer to any filamentous or pointed outgrowth of an embryonal or tissue-culture neural cell.
Ganglia, Sensory
Neurofibromatoses
A group of disorders characterized by an autosomal dominant pattern of inheritance with high rates of spontaneous mutation and multiple neurofibromas or neurilemmomas. NEUROFIBROMATOSIS 1 (generalized neurofibromatosis) accounts for approximately 95% of cases, although multiple additional subtypes (e.g., NEUROFIBROMATOSIS 2, neurofibromatosis 3, etc.) have been described. (From Neurochirurgie 1998 Nov;44(4):267-72)
Cell Adhesion Molecules, Neuronal
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
Cell Movement
Ganglioside Galactosyltransferase
Nerve Degeneration
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
Brain Chemistry
Drosophila melanogaster
Gene Expression Regulation
Leukocytes, Mononuclear
Sciatic Neuropathy
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
Myelin Basic Protein
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Neuritis
Trigeminal Ganglion
Central Nervous System Helminthiasis
Tibial Nerve
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Organ Specificity
Zebrafish
Membrane Proteins
Brain Stem
Leukodystrophy, Globoid Cell
An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.
Nerve Tissue
Diabetic Neuropathies
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
Basic Helix-Loop-Helix Transcription Factors
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Tissue Distribution
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Unsuccessful surgical treatment of hip dislocation in congenital sensory neuropathy with anhidrosis. A case report. (1/1736)
A six-year-old girl with congenital sensory neuropathy with anhidrosis (CSNA) presented with bilateral hip dysplasia and subluxation on the right side. Conservative treatment of the hips by closed reduction and a plaster cast was unsuccessful. When aged seven years the patient had an intertrochanteric varus rotation osteotomy on the right side, but subluxation was again evident after five months. A Salter-type pelvic osteotomy was carried out followed by immobilisation, but one year later subluxation was present in the right hip and dislocation in the left. At the age of nine years, the right femoral head resembled a Charcot joint, although walking ability was preserved. In patients with CSNA, surgery may not always be advisable. (+info)Phase II study of cisplatin and vinorelbine as first-line chemotherapy in patients with carcinoma of the uterine cervix. (2/1736)
PURPOSE: To evaluate the activity and toxicity of the combination of cisplatin (80 mg/m2 day 1) and vinorelbine (25 mg/m2 days 1 and 8) in patients with carcinoma of the uterine cervix that has not been previously treated with chemotherapy. PATIENTS AND METHODS: Fifty patients with cervical cancer were enrolled onto this study (27 stage IB-III, 23 stage IVB-recurrent). A two-stage optimal Simon design was applied. Thirteen responders of 29 treated patients were required to proceed beyond the first stage, and 28 responders were needed overall. RESULTS: Hematologic toxicity was mild, with neutropenia being the most frequent side effect. Nonhematologic toxicity was frequent but never severe; one patient had grade 3 peripheral neurotoxicity. Objective responses were recorded for 32 patients (64%): 11 patients (22%) achieved a complete response (CR) and 21 patients (42%) achieved a partial response (PR). The response rate was 81.5% in patients with IB-III stage (25.9% CR rate) and 43.5% in patients with IVB-recurrent disease (17.4% CR rate). Responses were seen both in stage IVB patients (one CR and two PRs, for an overall rate of 37.5%) and in patients with recurrent disease (three CRs + four PRs, for an overall rate of 46.7%). CONCLUSION: The combination of cisplatin and vinorelbine is an active regimen in the treatment of patients with early-stage and advanced carcinoma of the uterine cervix. The hematologic and nonhematologic toxicity of this combination is mild. (+info)Clinicopathological features of Churg-Strauss syndrome-associated neuropathy. (3/1736)
We assessed the clinicopathological features of 28 patients with peripheral neuropathy associated with Churg-Strauss syndrome. Initial symptoms attributable to neuropathy were acute painful dysaesthesiae and oedema in the dysaesthetic portion of the distal limbs. Sensory and motor involvement mostly showed a pattern of mononeuritis multiplex in the initial phase, progressing into asymmetrical polyneuropathy, restricted to the limbs. Parallel loss of myelinated and unmyelinated fibres due to axonal degeneration was evident as decreased or absent amplitudes of sensory nerve action potentials and compound muscle action potentials, indicating acute massive axonal loss. Epineurial necrotizing vasculitis was seen in 54% of cases; infiltrates consisted mainly of CD8-positive suppressor/cytotoxic and CD4-positive helper T lymphocytes. Eosinophils were present in infiltrates, but in smaller numbers than lymphocytes. CD20-positive B lymphocytes were seen only occasionally. Deposits of IgG, C3d, IgE and major basic protein were scarce. The mean follow-up period was 4.2 years, with a range of 8 months to 10 years. Fatal outcome was seen only in a single patient, indicating a good survival rate. The patients who responded well to the initial corticosteroid therapy within 4 weeks regained self-controlled functional status in longterm follow-up (modified Rankin score was < or = 2), while those not responding well to the initial corticosteroid therapy led a dependent existence (P < 0.01). In addition the patients with poor functional outcomes had significantly more systemic organ damage caused by vasculitis (P < 0.05). Necrotizing vasculitis mediated by cytotoxic T cells, leading to ischaemic changes, appears to be a major cause of Churg-Strauss syndrome-associated neuropathy. The initial clinical course and the extent of systemic vasculitic lesions may influence the long-term functional prognosis. (+info)Neurological complications of neurofibromatosis type 1 in adulthood. (4/1736)
Neurofibromatosis type 1 (NF1) is a genetic disease with a wide range of neurological manifestations. To examine these, and to evaluate neurological morbidity in adulthood of patients with NF1, we studied a hospital-based series of 158 patients that included 138 adult patients aged >18 years and 20 children. NF1 evaluation included a multidisciplinary clinical and a clinically oriented radiological investigation. Neurological events occurring during childhood (in both children and adults of the series) and adulthood were recorded. One or several neurological manifestations have been observed in 55% of patients (adults and children) (n = 87). These included: headache (28 patients); hydrocephalus (7); epilepsy (5); lacunar stroke (1); white matter disease (1); intraspinal neurofibroma (3); facial palsy (1); radiculopathy (5); and polyneuropathy (2). Tumours included: optic pathway tumours (20); meningioma (2); cerebral glioma (3); and malignant peripheral nerve sheath tumours (6). Life-threatening complications were observed in five adults and included four malignant peripheral nerve sheath tumours and one meningioma. Pain was the leading symptom in 11 adults and was related to malignant peripheral nerve sheath tumours, complications of intraspinal neurofibromas, subcutaneous neurofibromas and peripheral nerve neurofibromas. NF1 in adults was not associated with other disabling or life-threatening neurological complications. Symptomatic optic pathway tumours, cerebral gliomas, symptomatic aqueductal stenosis and spinal compression due to intraspinal NF were observed exclusively during childhood. In this series, the predominant neurological features of adults with NF1 were chronic pain and malignant peripheral nerve sheath tumours. (+info)Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data. (5/1736)
In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and kidney of affected cats revealed contamination with the ionophor salinomycin. Epidemiologic and clinical data were collected from 823 cats, or about 1% of the cats at risk. In 21 affected cats, postmortem examination was performed. The affected cats had acute onset of lameness and paralysis of the hindlimbs followed by the forelimbs. Clinical and pathologic examination indicated a distal polyneuropathy involving both the sensory and motor nerves. (+info)Ten- to 15-year outcome of surgery for lumbar disc herniation: radiographic instability and clinical findings. (6/1736)
The most appropriate treatment for radiculopathy associated with disc pathology is still controversial. Since 1934, surgical treatment has consisted of hemilaminectomy and removal of the herniated material. Many authors believe that these procedures may cause degenerative spondylosis and vertebral instability. Several surgical methods have been proposed, but the long-term effects are still being debated. In addition there appear to be few well-designed outcome studies on the management of this disease. In the present study, 150 patients were selected for surgery with strict criteria and all treated with the standard technique. The series was evaluated by subjective analyses (Roland questionnaire; 120 patients), objective examinations (68 patients - 56.6%) and radiographic studies including dynamic views (analyzed by the Taillard and Boxall methods) to establish the presence of vertebral instability (50 patients - 41.6%). The subjective and objective analyses showed a high rate of good results. Radiographic studies showed vertebral instability in 30 cases, but only 9 were symptomatic. Recurrences were not observed and only a few patients suffered from leg pain. The standard procedure for lumbar disc herniation showed good results at 10- and 15-year follow-up. (+info)Successful treatment of IgM paraproteinaemic neuropathy with fludarabine. (7/1736)
OBJECTIVES: To evaluate the response of four patients with IgM paraproteinaemic neuropathy to a novel therapy-pulsed intravenous fludarabine. BACKGROUND: The peripheral neuropathy associated with IgM paraproteinaemia usually runs a chronic, slowly progressive course which may eventually cause severe disability. Treatment with conventional immunosuppressive regimens has been unsatisfactory. Fludarabine is a novel purine analogue which has recently been shown to be effective in low grade lymphoid malignancies. METHODS: Four patients were treated with IgM paraproteinaemic neuropathy with intravenous pulses of fludarabine. Two of the four patients had antibodies to MAG and characteristic widely spaced myelin on nerve biopsy and a third had characteristic widely spaced myelin only. The fourth had an endoneurial lymphocytic infiltrate on nerve biopsy and a diagnosis of Waldenstrom's macroglobulinaemia. RESULTS: In all cases subjective and objective clinical improvement occurred associated with a significant fall in the IgM paraprotein concentration in three cases. Neurophysiological parameters improved in the three patients examined. The treatment was well tolerated. All patients developed mild, reversible lymphopenia and 50% mild generalised myelosuppression, but there were no febrile episodes. CONCLUSION: Fludarabine should be considered as a possible treatment for patients with IgM MGUS paraproteinaemic neuropathy. (+info)Vasculitic polyradiculopathy in systemic lupus erythematosus. (8/1736)
A 22 year old woman with recently diagnosed systemic lupus erythematosus presented with subacute progressive areflexic paraparesis, electrophysiologically identified as a pure axonal polyradiculopathy. Sural nerve biopsy disclosed necrotising vasculitis. A striking radiological feature was marked enhancement of the cauda equina with gadolinium. (+info)
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Postural sway in diabetic peripheral neuropathy among Indian elderly<...
Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and...
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Diagnostic efficiency and treatment strategy in chronic axonal polyneuropathy
peripheral neuropathy [Lymphedema People]
Sural nerve biopsy in peripheral neuropathies: 30-year experience from a single center<...
Willison, Hugh - ISNI - International Society of Neuroimmunology
Optochiasmatic and peripheral neuropathy due to ethambutol overtreatment<...
Specialized Neurology (ENFD) - Bako Diagnostics
Peripheral Nerve Disorders - Crashing Patient
Multiple Mononeuropathy - Brain, Spinal Cord, and Nerve Disorders - Merck Manuals Consumer Version
Hereditary Neuropathy With Liability to Pressure Palsies (HNLPP) - Brain, Spinal Cord, and Nerve Disorders - Merck Manuals...
The Foundation For Peripheral Neuropathy AIDS & HIV Peripheral Neuropathy - Symptoms | HIV Neuropathy Treatment
Peripheral Nerve Disorders and Anterior Horn Cell Diseases | Rudolphs Pediatrics, 23e | AccessPediatrics | McGraw-Hill Medical
Diabetic Peripheral Neuropathy - Pipeline Review, H1 2020 - Global Markets Directs
Autophagy in the posterior interosseous nerve of patients with type 1 and type 2 diabetes mellitus: an ultrastructural study
AAN Annual Meeting Programs: C131 - Small Fiber Neuropathies: Sensory, Autonomic, and Both I: Focus on Autonomic Nervous System...
Aging | Jinmaitong ameliorates diabetic peripheral neuropathy in streptozotocin-induced diabetic rats by modulating gut...
Foot Kinetic and Kinematic Profile in Type 2 Diabetes Mellitus with Peripheral Neuropathy <sub>A...
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Neuropathic symptoms and their risk factors in medical oncology outpatients with colorectal vs. breast, lung, or prostate...
Diabetic Neuropathies: The Nerve Damage Of Diabetes - Defeat Sugar Diabetes
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Hypotension & Severe Peripheral Motor Neuropathy<...
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Peripheral Neuropathy facts, information, pictures | Encyclopedia.com articles about Peripheral Neuropathy
Detection of peripheral nerve pathology | Neurology
Superior oblique myokymia
Diseases relating to the peripheral nervous system. Mononeuropathy. Arm. median nerve. *Carpal tunnel syndrome ... Diagnosis is most often made by the elimination of other conditions, disorders or diseases. Onset usually occurs in adulthood, ...
Radiculopathy
Diseases relating to the peripheral nervous system. Mononeuropathy. Arm. median nerve. *Carpal tunnel syndrome ... "Lyme Disease Data and surveillance". Lyme Disease. Centers for Disease Control and Prevention. 2019-02-05. Retrieved April 12, ... "Lyme Disease risk areas map". Risk of Lyme disease to Canadians. Government of Canada. 2015-01-27. Retrieved May 8, 2019.. ... Lyme disease" (PDF). The New England Journal of Medicine. 370 (18): 1724-31. doi:10.1056/NEJMcp1314325. PMC 4487875. PMID ...
Guillain-Barré syndrome
Autoimmune diseases. *Syndromes affecting the nervous system. *Peripheral nervous system disorders. *Cytomegalovirus-associated ... is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system.[2] The initial symptoms ... Rinaldi, Simon (June 2013). "Update on Guillain-Barré syndrome". Journal of the Peripheral Nervous System. 18 (2): 99-112. doi: ... Journal of the Peripheral Nervous System. 19 (1): 24-35. doi:10.1111/jns5.12051. PMID 24456426.. ...
Specialty (medicine)
Disease of the central nervous system, peripheral nervous system, and spinal column. ... The endocrine system (i.e., endocrine glands and hormones) and its diseases, including diabetes and thyroid diseases. ... Neuropsychiatry focuses on affective, cognitive and behavioral disorders attributable to diseases of the nervous system ... Autoimmune and inflammatory diseases of the joints and other organ systems, such as arthritis and other rheumatic diseases. ...
Neuroscience
Neurology works with diseases of the central and peripheral nervous systems, such as amyotrophic lateral sclerosis (ALS) and ... the central nervous system (defined as the brain and spinal cord), and the peripheral nervous system. In many species - ... Neurosurgery and psychosurgery work primarily with surgical treatment of diseases of the central and peripheral nervous systems ... The scientific study of the biological mechanisms that underlie the disorders and diseases of the nervous system. ...
Talk:Neurology
the study of the anatomy, physiology, and diseases of the nervous system ... It also deals deals with the diagnosis and treatment of all categories of disease involving the central, peripheral, and ... Neurology as the studying of the Nervous System[edit]. Does Neurology study the nervous system per se. or only its disorders ? ... study of the nervous system." Dirac66 (talk) 17:14, 21 December 2010 (UTC). *It is also the study of the nervous system and ...
Spinal cord stimulator
... of neurostimulation of the spinal cord and peripheral nervous system for the treatment of chronic pain and ischemic diseases: ... If pain control and increased activity was achieved, a permanent system, with leads and a pulse generator, is placed.[citation ... The most common use of SCS is failed back surgery syndrome (FBSS) in the United States and peripheral ischemic pain in Europe.[ ... understood but may involve masking pain sensation with tingling by altering the pain processing of the central nervous system.[ ...
Neuroscience
Neurology works with diseases of the central and peripheral nervous systems, such as amyotrophic lateral sclerosis (ALS) and ... the nervous system can be split into two parts, the central nervous system (brain and spinal cord), and the peripheral nervous ... Neurosurgery and psychosurgery work primarily with surgical treatment of diseases of the central and peripheral nervous systems ... The scientific study of the biological mechanisms that underlie the disorders and diseases of the nervous system. ...
Capsaicin - Wicipedia
Poen, polyniwropatheg diabetig, yr eryr, peripheral nervous system disease Dynodwyr. Freebase. /M/0fs8j ...
Aminoacyl tRNA synthetase
Charcot-Marie-Tooth (CMT) is the most frequent heritable disorder of the peripheral nervous system (a neuronal disease) and is ... These correlations between aaRSs and certain diseases have opened up a new door to synthesizing therapeutics.[17] ... Certain diseases' causation (such as neuronal pathologies, cancer, disturbed metabolic conditions, and autoimmune disorders) ... Francklyn C, Musier-Forsyth K, Martinis SA (September 1997). "Aminoacyl-tRNA synthetases in biology and disease: new evidence ...
Andrea Prader
... related to chronic adrenal insufficiency combined with demyelinating disease of the brain and peripheral nervous system. They ... Disease of the supra-renal capsules". London Hospital Gazette. 43: 517-8. ,access-date= requires ,url= (help) Schilder, PF ( ... Schilder's disease). Females are not affected by the condition, however due to linkage of heredity with the X chromosome, they ... Addison-Schilder's disease). Today the eponymous title recognizes the physicians who first described it (Siemerling and ...
Epigenetics of neurodegenerative diseases
Peripheral nervous system (PNS) diseases may be further categorized by the type of nerve cell (motor, sensory, or both) ... Neurodegenerative diseases of the central nervous system[edit]. Alzheimer's Disease (AD)[edit]. Main article: Alzheimer's ... 3 Neurodegenerative diseases of the central nervous system *3.1 Alzheimer's Disease (AD) *3.1.1 Epigenetic factors ... complex disorders linked by the degeneration of neurons in either the peripheral nervous system or the central nervous system. ...
Demyelinating disease
The demyelinating diseases of the peripheral nervous system include: *Guillain-Barré syndrome and its chronic counterpart, ... A demyelinating disease is any disease of the nervous system in which the myelin sheath of neurons is damaged.[1] This damage ... Demyelinating diseases can be divided in those affecting the central nervous system (CNS) and those affecting the peripheral ... Fernández O.; Fernández V.E.; Guerrero M. (2015). "Demyelinating diseases of the central nervous system". Medicine. 11 (77): ...
Peripheral neuropathy - Simple English Wikipedia, the free encyclopedia
Peripheral neuropathy happens when the nerves of the peripheral nervous system suffer damage due to disease, trauma to the ... Retrieved from "https://simple.wikipedia.org/w/index.php?title=Peripheral_neuropathy&oldid=4458981" ...
Peripheral nervous system
DiseaseEdit. Main article: Peripheral neuropathy. Diseases of the peripheral nervous system can be specific to one or more ... The peripheral nervous system is divided into the somatic nervous system, and the autonomic nervous system. The somatic nervous ... The peripheral nervous system is divided into the somatic nervous system and the autonomic nervous system. In the somatic ... The peripheral nervous system (PNS) is one of the two components of the nervous system, the other part is the central nervous ...
Charcot-Marie-Tooth disease
... (CMT) is a hereditary motor and sensory neuropathy of the peripheral nervous system characterized ... "Neurophysiologic abnormalities in children with Charcot-Marie-Tooth disease type 1A". Journal of the Peripheral Nervous System ... Further information: Charcot-Marie-Tooth disease classifications. CMT is a heterogeneous disease and the mutations linked to it ... In 2010, CMT was one of the first diseases where the genetic cause of a particular patient's disease was precisely determined ...
Mary Reilly (academic)
Reilly, Mary M.; Murphy, Sinéad M.; Laurá, Matilde (2011). "Charcot-Marie-Tooth disease". Journal of the Peripheral Nervous ... System. 16 (1): 1-14. doi:10.1111/j.1529-8027.2011.00324.x. ISSN 1529-8027. PMID 21504497. "First clinical trial for Charcot ... She began to study neuromuscular disease, in particular Charcot-Marie-Tooth disease. In 2004, she found that Vitamin C could be ... Reilly has served as President of the British Peripheral Nerve Society and the International Peripheral Nerve Society. In 2015 ...
Peripheral neuropathy
... "nervous system" and -pathy, "disease of")[8] without modifier usually means peripheral neuropathy. ... non-sensory nervous system (i.e., the autonomic nervous system), affecting mostly the internal organs such as the bladder ... Neuritis is a general term for inflammation of a nerve[22] or the general inflammation of the peripheral nervous system. ... Peripheral neuropathy, often shortened to neuropathy, is a general term describing disease affecting the peripheral nerves, ...
Itch
They could include diseases or disorders in the central nervous system or peripheral nervous system. Examples of neuropathic ... or changes in hormonal balances associated with aging Itch can originate in the peripheral nervous system (dermal or ... Neuropathic itch can originate at any point along the afferent pathway as a result of damage of the nervous system. ... or in the central nervous system (neuropathic, neurogenic, or psychogenic). Itch originating in the skin is known as ...
Andermann syndrome
In the Peripheral nervous system, the disease is more severe. While most nervous system diseases affect either CNS or PNS, this ... disease affects both, but it is the changes in the peripheral nervous system that lead to death. This occurs by axonal disease ... neuropathological features in the central and peripheral nervous system". Modern Pathology. 29 (9): 962-976. doi:10.1038/ ... In the central nervous system, accompanying the hypotonia at birth is hypoplasia of the corticospinal tracts. Another ...
Extrachromosomal DNA
... central and peripheral nervous systems, smooth muscle and hearing in humans. There have been mixed, and sometimes conflicting, ... Mitochondrial DNA can play a role in the onset of disease in a variety of ways. Point mutations in or alternative gene ... arrangements of mtDNA have been linked to several diseases that affect the heart, central nervous system, endocrine system, ... Loss of the amount of mtDNA present in the mitochondria can lead to a whole subset of diseases known as mitochondrial depletion ...
جراحی مغز و اعصاب - ویکیپدیا، دانشنامهٔ آزاد
This includes the central nervous system and the peripheral nervous system. Tissue analysis comes from either surgical biopsies ... Alzheimer's disease, dementia, Huntington's disease, amyotrophic lateral sclerosis, mitochondria disease, and any disorder that ... Surgery of the peripheral nervous system is also possible, and includes the very common procedures of carpal tunnel ... Numerous other types of nerve entrapment conditions and other problems with the peripheral nervous system are treated as well.[ ...
Sympathetic nervous system
... as well as peripheral vasoconstriction to maintain blood pressure. However, these effects accelerate disease progression, ... In the sympathetic nervous system and other components of the peripheral nervous system, these synapses are made at sites ... Together with the other component of the autonomic nervous system, the parasympathetic nervous system, the sympathetic nervous ... The sympathetic nervous system (SNS) is one of the two main divisions of the autonomic nervous system, the other being the ...
Neurogenic bladder dysfunction
This coordination can be disrupted by damage or diseases of the central nervous system, peripheral nerves or autonomic nervous ... refers to urinary bladder problems due to disease or injury of the central nervous system or peripheral nerves involved in the ... peripheral nerve damage, Parkinson's disease, or other neurodegenerative diseases. Neurogenic bladder can be diagnosed through ... Peripheral nerves can also be damaged as a complication of major surgery of the pelvis, such as for removal of tumors. The ...
Vasculitic neuropathy
Some patients with systemic vasculitis will have their multi-organ disease spread to the peripheral nervous system; this is ... It can be as part of a systemic problem or can exist as a single-organ issue only affecting the peripheral nervous system (PNS ... Vasculitic neuropathy is a peripheral neuropathic disease. In a vasculitic neuropathy there is damage to the vessels that ... Infectious diseases: hepatitis B, hepatitis C, human immunodeficiency virus (HIV), cytomegalovirus, lyme disease, human T-cell- ...
Neuroscience
Neurology works with diseases of the central and peripheral nervous systems, such as amyotrophic lateral sclerosis (ALS) and ... the central nervous system (defined as the brain and spinal cord), and the peripheral nervous system. In many species - ... Neurosurgery and psychosurgery work primarily with surgical treatment of diseases of the central and peripheral nervous systems ... A nervous system emerges from the assemblage of neurons that are connected to each other. The vertebrate nervous system can be ...
P. A. L. Wight
Wight, P. a. L. (1960). A histological study of the spinal cord and peripheral nervous system in scrapie disease of sheep ( ... As these involve the animal's nervous system he moved onto the field of neuropathology. In 1956, he returned to Britain to work ... The Histopathology of Marek's Disease Oregon Disease in Turkeys Who's Who in Commerce and Industry vol 14 SILLER, WALTER G. " ... Here he mainly worked on mainstream African animal diseases such as Heartwater and Rabies. ...
Uniejów
The following diseases can be treated here: orthopedic and traumatic, nervous, rheumatological, peripheral nervous system, skin ...
Antiganglioside antibodies
... motor neuron disease, peripheral neuropathy, and other diseases of the nervous system". J. Neuroimmunol. 56 (1): 27-33. doi: ... 1989). "Total, anti-viral, and anti-myelin IgG subclass reactivity in inflammatory diseases of the central nervous system". J. ... 2006). "Anti-ganglioside antibodies in coeliac disease with neurological disorders". Digestive and Liver Disease. 38 (3): 183-7 ... Antibodies to ganglioside are found to be elevated in coeliac disease. Recent studies show that gliadin can cross-link to ...
Charcot-Marie-Tooth disease
"Neurophysiologic abnormalities in children with Charcot-Marie-Tooth disease type 1A". Journal of the Peripheral Nervous System ... For other diseases, see Charcot disease (disambiguation).. Charcot-Marie-Tooth disease (CMT) is one of the hereditary motor and ... a group of varied inherited disorders of the peripheral nervous system characterized by progressive loss of muscle tissue and ... In 2010, CMT was one of the first diseases where the genetic cause of a particular patient's disease was precisely determined ...
Computational neuroscience
Peripheral nervous system. Somatic. *Sensory nerve. *Motor nerve. *Cranial nerve. *Spinal nerve ... Adaszewski S1, Dukart J, Kherif F, Frackowiak R, Draganski B; Alzheimer's Disease Neuroimaging Initiative (2013). "How early ... GENESIS, a general neural simulation system.. Conferences[edit]. *Computational and Systems Neuroscience (COSYNE) - a ... physiology and cognitive abilities of the nervous system.[1][2][3][4] ...
Type 2 diabetes
Diseases of the endocrine system (ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases - Endocrine diseases, E00- ... and inappropriate regulation of metabolism by the central nervous system.[10] However, not all people with insulin resistance ... peripheral neuropathy, recurrent vaginal infections, and fatigue.[13] Other symptoms may include loss of taste.[24] Many people ... nervous system activity, or hormonal factors that may lead to diabetes.[34] ...
Cushing's disease
... vegetative nervous system diseases and cerebral tumors. In 1926 he was the first one who described Itsenko-Cushing's disease, ... peripheral ratio of over 3:1 when CRH is administered is indicative of Cushing's disease.[7] This test has been the gold ... The disease is often diagnosed 3-6 years after the onset of illness.[19] Several studies have shown that Cushing's disease is ... Cases of Cushing's disease are rare, and little epidemiological data is available on the disease. An 18-year study conducted on ...
Substance P
... non-cholinergic nervous system (branch of the vagal system).. InflammationEdit. SP initiates expression of almost all known ... Blockade for diseases with a chronic immunological componentEdit. As increasingly documented, the SP-NK1R system induces or ... Substance P and other sensory neuropeptides can be released from the peripheral terminals of sensory nerve fibers in the skin, ... The actions of aprepitant are said to be entirely central, thus requiring passage of the drug into the central nervous system.[ ...
Medicine
Neurology is concerned with diseases of the nervous system. In the UK, neurology is a subspecialty of general medicine. ... is concerned with testing the physiology or function of the central and peripheral aspects of the nervous system. These kinds ... Neuroscience includes those disciplines of science that are related to the study of the nervous system. A main focus of ... Review of systems (ROS) or systems inquiry: a set of additional questions to ask, which may be missed on HPI: a general enquiry ...
Lyme disease
... peripheral nervous system, and central nervous system.[61][84] Many of the signs and symptoms of Lyme disease are a consequence ... Halperin JJ (June 2008). "Nervous system Lyme disease". Infectious Disease Clinics of North America. 22 (2): 261-74, vi. doi: ... Lyme disease can affect multiple body systems and produce a broad range of symptoms. Not everyone with Lyme disease has all of ... People treated only after nervous system manifestations of the disease may end up with objective neurological deficits, in ...
Chiropractic
... exerted via the human nervous system and is a primary underlying risk factor for many diseases.[36] Straights view the medical ... Impressions are made on the peripheral afferent fiber-endings; these create sensations that are transmitted to the center of ... In 1910, D. D. Palmer theorized that the nervous system controlled health: "Physiologists divide nerve-fibers, which form the ... affects the nervous system and may lead to reduced function, disability or illness."[50][51] ...
Inhalation
As such, it happens automatically (though there are exceptions in some disease states) and does not need conscious control or ... Central nervous system. *Intracerebral. *Intrathecal. *Epidural. Circulatory,. musculoskeletal. *Intravenous. *Intracardiac. * ...
Connective tissue
Mixed connective tissue disease - a disease of the autoimmune system, also undifferentiated connective tissue disease. ... tissue neoplasms including sarcomas such as hemangiopericytoma and malignant peripheral nerve sheath tumor in nervous tissue. ... including the nervous system. In the central nervous system, the three outer membranes (the meninges) that envelop the brain ... "Nutrition, Metabolism and Cardiovascular Diseases. 17 (2): 125-139. doi:10.1016/j.numecd.2006.10.005. PMC 4426988. PMID ...
Pleiotropy
... that affects multiple systems, such as the nervous and integumentary system.[2] Other examples of pleiotropy are albinism, ... A common example of pleiotropy is the human disease phenylketonuria (PKU). This disease causes mental retardation and reduced ... "Transcriptome Profiling of Peripheral Blood in 22q11.2 Deletion Syndrome Reveals Functional Pathways Related to Psychosis and ... Unconverted phenylalanine builds up in the bloodstream and can lead to levels that are toxic to the developing nervous system ...
GABAA receptor positive allosteric modulator
Neurosteroids are synthesized in the central nervous system (CNS) and the peripheral nervous system (PNS) from cholesterol and ... "Neuropsychiatric Disease and Treatment. 1 (4): 329-43. PMC 2424120. PMID 18568113.. .mw-parser-output cite.citation{font-style: ... Baulieu EE (1997). "Neurosteroids: of the nervous system, by the nervous system, for the nervous system". Recent Progress in ... GABA is a major inhibitory neurotransmitter in the central nervous system. Upon binding, it triggers the GABAA receptor to open ...
ادرار کردن - ویکیپدیا، دانشنامهٔ آزاد
The smooth muscle of the bladder, known as the detrusor, is innervated by sympathetic nervous system fibers from the lumbar ... When the sacral dorsal roots are cut in experimental animals or interrupted by diseases of the dorsal roots such as tabes ... central and peripheral neuronal control of the micturition cycle". Anat. Embryol. 192 (3): 195-209. doi:10.1007/BF00184744. ... Physiologically, urination involves coordination between the central, autonomic, and somatic nervous systems. Brain centers ...
Moclobemide
Tikal K, Hrabánková M (June 1993). "[Indications for antidepressive agents in relation to diseases of the cardiovascular system ... Moclobemide has good penetration across the blood brain barrier with peak plasma levels within the central nervous system ... except that in doses of 400 mg or higher peripheral reaction time may be impaired.[68] Peripheral oedema has been associated ... Alderman CP, Callary JA, Kent AL (July 1992). "Peripheral oedema associated with moclobemide". Med. J. Aust. 157 (2): 144. PMID ...
Hypothalamic-pituitary-adrenal axis
... including the metabolic system, cardiovascular system, immune system, reproductive system and central nervous system. The HPA ... During an immune response, proinflammatory cytokines (e.g. IL-1) are released into the peripheral circulation system and can ... Stress and disease[edit]. The HPA axis is involved in the neurobiology of mood disorders and functional illnesses, including ... At the hypothalamus, fear-signaling impulses activate both the sympathetic nervous system and the modulating systems of the HPA ...
Visual impairment
Malignant neoplasms of the brain and nervous system (1.5%). *Retinal detachment (1.4%) ... Stargardt's disease. *Uveitis: is a group of 30 intraocular inflammatory diseases[44] caused by infections, systemic diseases, ... with corrective glasses or central visual acuity of more than 20/200 if there is a visual field defect in which the peripheral ... a b c Morello, C. M. "Etiology and Natural History of Diabetic Retinopathy: An Overview." American Journal of Health-System ...
MT-TI
... particularly the muscles and nervous system. In most cases, the signs and symptoms of this disorder appear during childhood or ... Common symptoms include, myoclonus, myopathy, spasticity, epilepsy, peripheral neuropathy, dementia, ataxia, atrophy, and more. ... see also mitochondrial diseases. This article incorporates text from the United States National Library of Medicine, which is ...
Index of HIV/AIDS-related articles
Centers for Disease Control and Prevention (CDC) - Centers for Medicare and Medicaid Services (CMS) - central nervous system - ... pelvic inflammatory disease - peptide - perianal - perinatal - perinatal transmission - peripheral neuritis - peripheral ... efficacy - empirical - encephalitis - end-stage disease - endemic - endogenous - endoscopy - endotoxin - endpoint - enteric - ... NAT - National Cancer Institute (NCI) - National Institute of Allergy and Infectious Diseases (NIAID) - National Institute of ...
Familial amyloid polyneuropathy
The US Food and Drug Administration's Peripheral and Central Nervous System Drugs Advisory Committee rejected the drug in June ... or Corino de Andrade's disease,[1] is an autosomal dominant[2] neurodegenerative disease. It is a form of amyloidosis, and was ... especially in the peripheral nervous system, causing a progressive sensory and motor polyneuropathy. ... Autonomic testing, including quantitative sweat testing, can reveal involvement of the autonomic nervous system.[7] ...
White blood cell
... and disease of the spleen and central nervous system. They are rare in the blood, but numerous in the mucous membranes of the ... Neutrophilia is an increase in the absolute neutrophil count in the peripheral circulation. Normal blood values vary by age.[15 ... Chronic inflammation - especially juvenile rheumatoid arthritis, rheumatoid arthritis, Still's disease, Crohn's disease, ... are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign ...
Yohimbine
... of pre-synaptic α2 receptors facilitates the release of several neurotransmitters in the central and peripheral nervous system ... treatment or prevention of disease": 21 U.S.C. § 321(g)(1)(B).[23] However the legal position is not entirely straightforward,[ ... "Yohimbine pharmacokinetics and interaction with the sympathetic nervous system in normal volunteers". European Journal of ... Rao MR, Palada MC, Becker BN (2013). "Medicinal and aromatic plants in agroforestry systems". In Nain PK, Rao MR, Buck LE (eds ...
Chronic obstructive pulmonary disease
A procedure known as targeted lung denervation, which involves decreasing the parasympathetic nervous system supply of the ... those with a peripheral oxygen saturation less than 92%, and those with symptoms of congestive heart failure.[22] In areas of ... Chronic obstructive pulmonary disease. Other names. Chronic obstructive lung disease (COLD), chronic obstructive airway disease ... Most cases of COPD are a mixture of both diseases.. *^ "Chronic obstructive pulmonary disease (COPD)". WHO. Retrieved 5 June ...
Brain-derived neurotrophic factor
BDNF acts on certain neurons of the central nervous system and the peripheral nervous system, helping to support survival of ... Alzheimer's disease,[71] Huntington's disease,[72] Rett syndrome,[73] and dementia,[74] as well as anorexia nervosa[75] and ... Given that BDNF is critical for the survival of central nervous system (CNS) and peripheral nervous system (PNS) neurons and ... peripheral nervous system development. • memory. • nerve development. • nerve growth factor signaling pathway. • regulation of ...
Olfactory system
Peripheral[edit]. The peripheral olfactory system consists mainly of the nostrils, ethmoid bone, nasal cavity, and the ... These diseases have more moderate effects on the olfactory system than Alzheimer's or Parkinson's diseases.[39] Furthermore, ... "Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats". ... Most mammals and reptiles have a main olfactory system and an accessory olfactory system. The main olfactory system detects ...
Superoxide dismutase
... of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system". ... Role in disease[edit]. Mutations in the first SOD enzyme (SOD1) can cause familial amyotrophic lateral sclerosis (ALS, a form ... This was cut short by concerns about prion disease.[citation needed] An SOD-mimetic agent, TEMPOL, is currently in clinical ... In biological systems, this means that its main reactions are with itself (dismutation) or with another biological radical such ...
Olfactory ensheathing cells
Unlike the peripheral nervous system, the central nervous system is unable to regenerate damaged axons, so its synaptic ... Transplantation of stem cells is also known to cause toxicity and graft-versus-host disease (GVHD). Apoptotic cells have been ... due to their regenerate properties in the peripheral nervous system and their presence in the central nervous system.[2] OECs ... as they form the fascicles through which axons grow from the peripheral nervous system into the central nervous system.[5] ...
Kava
... kava has been used in the traditional medicine of the South Pacific Islands for central nervous system and peripheral effects.[ ... No information is available on the potential for kava beverage consumption to impact on the incidence of chronic disease. ... Ligresti A, Villano R, Allarà M, Ujváry I, Di Marzo V (2012). "Kavalactones and the endocannabinoid system: the plant-derived ... United States Centers for Disease Control and Prevention (2002). "Hepatic Toxicity Possibly Associated with Kava-Containing ...
History of England
The system was based on the existing counties (now known as the historic counties, since the major boundary changes of 1974). ... The English army suffered badly from disease, and Henry was not even present at the one notable victory, the Battle of the ... At best, the elite-dominance model might apply in the peripheral areas of the settlement territory, where an immigration ... The king became increasingly nervous about the possibility of his daughter Mary inheriting the throne, as England's one ...
Amyotrophic lateral sclerosis
Sontheimer, Harald (2015). Diseases of the Nervous System. Academic Press. p. 170. ISBN 978-0-12-800403-6. . Archived from the ... that the person has a form of peripheral neuropathy (damage to peripheral nerves) or myopathy (muscle disease) rather than ALS ... Disease Primers. 3 (17071): 17071. doi:10.1038/nrdp.2017.71. PMID 28980624.. *^ a b c d e f g h i j k l m n o p q r s t u v van ... Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND) or Lou Gehrig's disease, is a specific disease ...
Adrenal medulla
Ganglioneuroma, a tumor in the nerve cells of the peripheral nervous system[5] ... "Diseases of the adrenal medulla". Acta Physiologica. 192 (2): 325-335. doi:10.1111/j.1748-1716.2007.01809.x. PMC 2576282. PMID ... As a cluster of neuron cell bodies, the adrenal medulla is considered a modified ganglion of the sympathetic nervous system.[2] ... These cells are intimately connected with the sympathetic division of the autonomic nervous system (ANS). These adrenal ...
எயிட்சு - தமிழ் விக்கிப்பீடியா
World Health Organization (1990). "Interim proposal for a WHO staging system for HIV infection and disease". WHO Wkly Epidem. ... Luft BJ, Chua A (2000). "Central Nervous System Toxoplasmosis in HIV Pathogenesis, Diagnosis, and Therapy". Curr. Infect. Dis. ... "Symptom management and self-care for peripheral neuropathy in HIV/AIDS". AIDS Care 19 (2): 179-89. doi:10.1080/ ... 35.0 35.1 Tang J, Kaslow RA (2003). "The impact of host genetics on HIV infection and disease progression in the era of highly ...
Peripheral Nervous System Diseases | GreenMedInfo | Disease | Natural
Diseases : C-Reactive Protein, Peripheral Nerve Diseases, Peripheral Nervous System Diseases. Therapeutic Actions : Mud therapy ... Diseases : Celiac Disease, Gluten Sensitivity, Neuropathic Pain, Peripheral Nervous System Diseases, Peripheral Neuropathies ... 3 Abstracts with Peripheral Nervous System Diseases Research. Filter by Study Type. Human Study. ... 1 Therapeutic Actions Researched for Peripheral Nervous System Diseases Name. AC. CK. Focus. ...
Search of: Recruiting, Not yet recruiting, Available Studies | 'Peripheral Nervous System Diseases' - List Results -...
515 Studies found for: Recruiting, Not yet recruiting, Available Studies , Peripheral Nervous System Diseases ... Recruiting, Not yet recruiting, Available Studies , Peripheral Nervous System Diseases (515 records) ... Establishing of Neuronal-like Cells From Patients With Cisplatin-Induced Peripheral Neuropathy. *Peripheral Nervous System ... Chemotherapy Induced Peripheral Neuropathy (CIPN). *Chemotherapy-induced Peripheral Neuropathy. *Other: Arm 1: Investigational ...
Peripheral Nervous System Diseases | Harvard Catalyst Profiles | Harvard Catalyst
"Peripheral Nervous System Diseases" by people in Harvard Catalyst Profiles by year, and whether "Peripheral Nervous System ... Peripheral Nervous System Diseases*Peripheral Nervous System Diseases. *Peripheral Nervous System Disease ... "Peripheral Nervous System Diseases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ... Below are the most recent publications written about "Peripheral Nervous System Diseases" by people in Profiles. ...
Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of...
Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of ... Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of ... seeks to generate scientific advancements addressing the role of the autonomic nervous system in the regulation of peripheral ... may propose to develop resources in the form of novel tools or methodologies that when applied to the autonomic nervous system ...
Peripheral Nervous System Manifestations in a Sandhoff Disease Mouse Model: Nerve Conduction, Myelin Structure, Lipid Analysis
To investigate how abnormal GM2 catabolism affects the peripheral nervous system in a mouse model of Sandhoff disease (Hexb ... or compositional abnormalities in the peripheral nervous system of the murine model for Sandhoff disease, but do show the ... and lipid composition of the peripheral nervous system. Results: We detected no significant difference in signal impulse ... Background: Sandhoff disease is an inherited lysosomal storage disease caused by a mutation in the gene for the β-subunit (Hexb ...
The spinal cord as organizer of disease processes: II. The peripheral autonomic nervous system | The Journal of the American...
The spinal cord as organizer of disease processes: II. The peripheral autonomic nervous system. The Journal of the American ... Korr I. The spinal cord as organizer of disease processes: II. The peripheral autonomic nervous system. J Am Osteopath Assoc ... The spinal cord as organizer of disease processes: II. The peripheral autonomic nervous system ... The spinal cord as organizer of disease processes: II. The peripheral autonomic nervous system ...
A novel mutation of LRSAM1 in a Chinese family with Charcot‐Marie‐Tooth disease, Journal of the Peripheral Nervous System | 10...
Journal of the Peripheral Nervous System" on DeepDyve, the largest online rental service for scholarly research with thousands ... Add Journal to My Library Journal of the Peripheral Nervous System , Volume 23 (1) - Jan 1, 2018 ... http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of the Peripheral Nervous System Wiley http://www.deepdyve. ... Charcot‐Marie‐Tooth (CMT) disease is the most common inherited peripheral neuropathy characterized by progressive distal muscle ...
OPUS Würzburg | Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain:...
Patients with Fabry disease often remain undiagnosed until severe complications involving the kidney, heart, peripheral nerves ... Results: We describe the neuropathy in Fabry disease, focusing on peripheral small fiber dysfunction - the hallmark of early ... Peripheral pain can be chronic and/or occur as provoked attacks of excruciating pain. Manifestations of dysfunction of small ... The clinical course of peripheral pain is summarized, and the importance of medical history-taking, including family history, ...
Peripheral nervous system disease in Systemic Lupus Erythematosus: Results from an international, inception cohort study
...
Peripheral nervous system disease in Systemic Lupus Erythematosus: Results from an international, inception cohort study. ... Peripheral nervous system disease in Systemic Lupus Erythematosus: Results from an international, inception cohort study ... Peripheral nervous system disease in Systemic Lupus Erythematosus: Results from an international, inception cohort study. ... associations and outcomes in different types of peripheral nervous system (PNS) disease. Methods Patients were evaluated ...
Peripheral nervous system diseases | definition of Peripheral nervous system diseases by Medical dictionary
Peripheral nervous system diseases explanation free. What is Peripheral nervous system diseases? Meaning of Peripheral nervous ... system diseases medical term. What does Peripheral nervous system diseases mean? ... Looking for online definition of Peripheral nervous system diseases in the Medical Dictionary? ... Related to Peripheral nervous system diseases: Peripheral neuropathy, Central nervous system diseases, Spinal cord diseases ...
Peripheral Nervous System Diseases | Profiles RNS
"Peripheral Nervous System Diseases" by people in UAMS Profiles by year, and whether "Peripheral Nervous System Diseases" was a ... Peripheral Nervous System Diseases*Peripheral Nervous System Diseases. *Peripheral Nervous System Disease ... "Peripheral Nervous System Diseases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ... Below are the most recent publications written about "Peripheral Nervous System Diseases" by people in Profiles over the past ...
Peripheral Nervous System Diseases
Peripheral Nervous System Diseases | ISHAR Online
Background: Chemotherapy-induced peripheral neuropathy is a frequent side-effect of drugs that are used in the treatment of ... Background: Chemotherapy-induced peripheral neuropathy is a frequent side-effect of drugs that are used in the treatment of ... Background: Chemotherapy-induced peripheral neuropathy is a frequent side-effect of drugs that are used in the treatment of ... Chemotherapy-induced peripheral neuropathy (CIPN) is a serious dose-limiting side-effect without any FDA-approved treatment ...
Peripheral Diseases - The Nervous System | Coursera
Ways in which the peripheral nervous system is vulnerable. So, its vulnerable to say a, large molecules such as botulinum ... If you cut a, an axon in the peripheral nervous system, it can repair itself. ... system tends to be far more vulnerable, than is the central nervous system. ... Peripheral Diseases. Pour visualiser cette vidéo, veuillez activer JavaScript et envisagez une mise à niveau à un navigateur ...
Overcome Your Peripheral Nervous System Diseases | Howtohint.com
Therefore it is very important to know how you will overcome you peripheral nervous system diseases. This peripheral nervous ... Peripheral nervous system disease is the major disease that can lead to madness if proper measures are not taken within the ... It is important for to know how to overcome your peripheral nervous system disease since it is one of the disease which affects ... These nutrients are essential for the live of the nervous system. Also for you to overcome your peripheral nervous system ...
Peripheral Nervous System Diseases; Peripheral Nerve Diseases; Peripheral Neuropathies
Peripheral Nerve Diseases; Peripheral Neuropathies. On-line free medical diagnosis assistant. Ranked list of possible diseases ... A similarity measure between symptoms and diseases is provided. ... Peripheral Nervous System Diseases (Peripheral Nerve Diseases; ... Ranked list of diseases related to "Peripheral Nervous System Diseases"Drugs, active principles and "Peripheral Nervous System ... Peripheral Neuropathies). Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of ...
Neurofibromatosis - Health, Conditions and Diseases, Neurological Disorders, Peripheral Nervous System
Peripheral Nervous System Lyme Disease Definition in Medical Conditions Dictionary
Nervous system infections caused by tick-borne spirochetes of the BORELLIA BORGDORFERI GROUP. The disease may affect elements ... Definition of the term Peripheral Nervous System Lyme Disease: ... Autonomic Peripheral Nervous System Diseases. Diseases of the ... medical condition involving peripheral nervous system.. » Find the definition of Peripheral Nervous System Lyme Disease in ... Peripheral Nervous System Lyme Disease:. Nervous system infections caused by tick-borne spirochetes of the BORELLIA BORGDORFERI ...
Volume 36, Issue 1 | The American Journal of Tropical Medicine and Hygiene
Peripheral Nervous System Damage in Experimental Chronic Chagas' Disease Cappa S. M. González, O. P. Sanz, L. A. Muller, H ... were compared in their ability to cure two distinct Trypanosoma brucei brucei central nervous system murine model infections. ... Reservoir Competence of White-Footed Mice for Lyme Disease Spirochetes James G. Donahue, Joseph Piesman and Andrew Spielman ... Methyl Ester Alone and in Combination with Suramin against Trypanosoma brucei brucei Central Nervous System Models C. J. Bacchi ...
Compound Report Card
Peripheral Nervous System Diseases. D010523. EFO:0003100. peripheral neuropathy. 3. ClinicalTrials. Pneumococcal Infections. ... Peripheral Nervous System Diseases. D010523. EFO:0004149. neuropathy. 3. ClinicalTrials. Renal Insufficiency, Chronic. D051436 ... Kidney Diseases. D007674. EFO:0003086. kidney disease. 3. ClinicalTrials. Leukemia, Hairy Cell. D007943. EFO:1000956. hairy ... Crohn Disease. D003424. EFO:0000384. Crohns disease. 1. ClinicalTrials. Leukemia, Lymphoid. D007945. EFO:0004289. lymphoid ...
Compound Report Card
Peripheral Nervous System Diseases. D010523. EFO:0003100. peripheral neuropathy. 2. ClinicalTrials. Carcinoma, Non-Small-Cell ... Digestive System Diseases. D004066. EFO:0000405. digestive system disease. 1. ClinicalTrials. Gallbladder Neoplasms. D005706. ... Liver Diseases. D008107. EFO:0001421. liver disease. 1. ClinicalTrials. Ovarian Neoplasms. D010051. Orphanet:398934. Malignant ... Hodgkin Disease. D006689. EFO:0000183. Hodgkins lymphoma. 2. ClinicalTrials. Leukemia, Myeloid, Acute. D015470. EFO:0000222. ...
July 2007 - Volume 13 - Issue 4 : The Neurologist
Peripheral Nervous System Involvement in Patients With Behçet Disease. Atasoy, Huseyin Tugrul; Tunc, Tugba Oruc; Unal, Aysun ... The Pathological Presentations of Neuro-Behçet Disease: A Case Report and Review of the Literature. Haghighi, Afshin Borhani; ... Migraine With Aura Is a Risk Factor for Cardiovascular and Cerebrovascular Disease: A Critically Appraised Topic. Wingerchuk, ...
CISDOC - Clinical evaluation of 58 organolead manufacturing workers
Superior oblique myokymia - Wikipedia
Demyelinating disease - Wikipedia
The demyelinating diseases of the peripheral nervous system include: *Guillain-Barré syndrome and its chronic counterpart, ... A demyelinating disease is any disease of the nervous system in which the myelin sheath of neurons is damaged.[1] This damage ... Demyelinating diseases can be divided in those affecting the central nervous system (CNS) and those affecting the peripheral ... Fernández O.; Fernández V.E.; Guerrero M. (2015). "Demyelinating diseases of the central nervous system". Medicine. 11 (77): ...
Peripheral neuropathy and central nervous system lesions in canine globoid-cell leukodystrophy (Krabbe's disease).<...
Peripheral neuropathy and central nervous system lesions in canine globoid-cell leukodystrophy (Krabbes disease). South Dakota ... Peripheral neuropathy and central nervous system lesions in canine globoid-cell leukodystrophy (Krabbes disease). / Kurtz, H. ... title = "Peripheral neuropathy and central nervous system lesions in canine globoid-cell leukodystrophy (Krabbes disease).", ... T1 - Peripheral neuropathy and central nervous system lesions in canine globoid-cell leukodystrophy (Krabbes disease). ...
Peripheral Neuropathy | MedlinePlus
Learn about neuropathy and more than 100 other types of peripheral nerve disorders. ... Peripheral nerves are nerves outside your brain and spinal cord. ... Peripheral Nervous System Diseases (National Institutes of ... What Are the Parts of the Nervous System? (Eunice Kennedy Shriver National Institute of Child Health and Human Development) ... Your peripheral nerves are the ones outside your brain and spinal cord. Like static on a telephone line, peripheral nerve ...
APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated...
Peripheral Nervous System Diseases. Neuromuscular Diseases. Nervous System Diseases. Proteostasis Deficiencies. Metabolic ... Heredodegenerative Disorders, Nervous System. Neurodegenerative Diseases. Genetic Diseases, Inborn. Metabolism, Inborn Errors. ... Condition or disease Intervention/treatment Phase TTR-mediated Amyloidosis Amyloidosis, Hereditary Amyloid Neuropathies, ... Genetic and Rare Diseases Information Center resources: Familial Transthyretin Amyloidosis Amyloid Neuropathy ...
Comparing Two Different Cervical Collars for the Treatment in Patient With Cervical Radiculopathy and Radicular Pain - Full...
Peripheral Nervous System Diseases. Neuromuscular Diseases. Nervous System Diseases. Acetaminophen. Analgesics, Non-Narcotic. ... Sensory System Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. Antipyretics. ... Condition or disease Intervention/treatment Phase Cervical Radiculopathy Radicular Pain Acute Neck Pain Cervicobrachial Pain ...
The| peripheral nervous system complications of HIV infection | Libyan Journal of Infectious Diseases [The]. 2007; 1 (2): 63...
Peripheral Nervous System Diseases/therapy , Peripheral Nervous System Diseases/diagnosis , Peripheral Nervous System Diseases/ ... Peripheral Nervous System Diseases / Early Diagnosis / Myositis Type of study: Screening_studies Limits: Humans Language: ... Peripheral Nervous System Diseases / Early Diagnosis / Myositis Type of study: Screening_studies Limits: Humans Language: ... Humans , Polyneuropathies/etiology , Polyneuropathies/virology , Peripheral Nervous System Diseases/virology , Myositis/ ...
NeuropathyNervesAutonomicNeuropathiesSpinalDiagnosisClinicalMultiple sclerosisSymptomsInfectious DiseasesSensoryNeuronsPatientsNeurologic diseaseEtiologyChronicInvolvementAffectsPathogenesisDemyelinationAutoimmune Diseases2016Musculoskeletal systemAxonNeurodegenerative diseasesInfectionInflammatoryLesionsDisorders of the nervous systemDigestiveAffect the nervous systemNeurological diseasesAlzheimer's DiseaseEndocrineGeneticNeuropathic painAbnormalitiesDysfunctionParkinson's DiseaseDiabetesTherapeuticCenters for DiseasKrabbeRheumatoidCranialSympathetic nervouMethodsLysosomalBody's
Neuropathy28
- Also searched for Peripheral neuropathy . (clinicaltrials.gov)
- Descriptive Statistics to measure the degree of peripheral neuropathy in the two arms based on the PQAS score. (clinicaltrials.gov)
- Staff NP, Fehrenbacher JC, Caillaud M, Damaj MI, Segal RA, Rieger S. Pathogenesis of paclitaxel-induced peripheral neuropathy: A current review of in vitro and in vivo findings using rodent and human model systems. (harvard.edu)
- Liu, Xiaomin 2018-01-01 00:00:00 Charcot‐Marie‐Tooth (CMT) disease is the most common inherited peripheral neuropathy characterized by progressive distal muscle weakness and atrophy with decreased or absent tendon reflexes. (deepdyve.com)
- Charcot‐Marie‐Tooth (CMT) disease is the most common inherited peripheral neuropathy characterized by progressive distal muscle weakness and atrophy with decreased or absent tendon reflexes. (deepdyve.com)
- Small, unmyelinated nerve fibers are particularly affected and small fiber peripheral neuropathy often clinically manifests at young age. (uni-wuerzburg.de)
- Results: We describe the neuropathy in Fabry disease, focusing on peripheral small fiber dysfunction - the hallmark of early neurologic involvement in this disorder. (uni-wuerzburg.de)
- Conclusions: Our recommendations can assist in diagnosing Fabry small fiber neuropathy early, and offer clinicians guidance in controlling peripheral pain. (uni-wuerzburg.de)
- Multivariate Cox regressions suggested longer time to resolution in patients with prior history of neuropathy, older age at SLE diagnosis, higher SLEDAI‐2K scores, and for peripheral neuropathy versus other neuropathies. (ucl.ac.uk)
- By physician assessment, the majority of neuropathies resolved or improved over time and this was associated with improvements in SF‐36 summary scores for peripheral neuropathy and mononeuropathy. (ucl.ac.uk)
- Analysis of youtube as a source of information for peripheral neuropathy. (uams.edu)
- Background: Chemotherapy-induced peripheral neuropathy is a frequent side-effect of drugs that are used in the treatment of cancer. (isharonline.org)
- Chemotherapy-induced peripheral neuropathy (CIPN) is a serious dose-limiting side-effect without any FDA-approved treatment option. (isharonline.org)
- AIM: To identify which of the examined agents or modalities were effective in the management of chemotherapy-induced peripheral neuropathy (CIPN). (isharonline.org)
- Peripheral neuropathy and central nervous system lesions in canine globoid-cell leukodystrophy (Krabbe's disease). (umn.edu)
- Hypothyroidism: Can It Cause Peripheral Neuropathy? (medlineplus.gov)
- 1.Type 2 diabetic peripheral neuropathy;2. (chinastemcell.com.cn)
- Thus, the presence and levels of scrum anti-PNS antibodies in leprosy appear to be unrelated to parameters of disease activity, neuropathy in particular, and do not seem to be critically involved in the pathogenesis of nerve damage. (ilsl.br)
- He had a history of high blood lead levels and peripheral neuropathy documented by electromyography. (elsevier.es)
- MayoClinic.com explains that erectile dysfunction, constipation and bladder problems continue the roster of misfortunes visited upon those who live with diabetic neuropathy of the autonomic nervous system. (livestrong.com)
- Screening occupational populations for asymptomatic or early peripheral neuropathy. (cdc.gov)
- Available techniques for screening workers at risk for peripheral neuropathy from exposure to neurotoxins are of three types: those based on neurological history, those based on neurological examination, and those based on neurophysiological or electrodiagnostic testing. (cdc.gov)
- The purpose of this study is to determine if acetyl-L-carnitine (ALC) reduces pain, numbness, and tingling in the feet and legs of patients with nucleoside reverse transcriptase inhibitor (NRTI)-associated peripheral neuropathy. (clinicalconnection.com)
- Distal symmetric peripheral neuropathy (DSPN) is the most frequent neurologic complication of HIV infection and its treatments. (clinicalconnection.com)
- Neuropathy, also known as peripheral neuropathy, is disease in the peripheral nerves the nerves that lead to and from the spinal cord and connect with all the various parts of the body. (healthcommunities.com)
- The feet and legs are most often affected by peripheral neuropathy, but as time progresses without treatment the hands may become affected as well. (rarediseases.org)
- Participants had experienced moderate or severe neuropathic pain for at least three months due to cancer, cancer treatment, postherpetic neuralgia, peripheral diabetic neuropathy, spinal cord injury, or polyneuropathy. (mendeley.com)
- About thirty percent of all cancer patients receiving chemotherapy suffer from chemotherapy-induced peripheral neuropathy (CIPN), which makes CIPN one of the most significant side effects of many widely used antineoplastic drugs. (uni-heidelberg.de)
Nerves22
- Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves. (harvard.edu)
- To investigate how abnormal GM2 catabolism affects the peripheral nervous system in a mouse model of Sandhoff disease (Hexb-/-), we examined the electrophysiology of dissected sciatic nerves, structure of central and peripheral myelin, and lipid composition of the peripheral nervous system. (harvard.edu)
- Patients with Fabry disease often remain undiagnosed until severe complications involving the kidney, heart, peripheral nerves and/or brain have arisen. (uni-wuerzburg.de)
- Your peripheral nerves are the ones outside your brain and spinal cord. (medlineplus.gov)
- Chronic work related syndrome is typical of many injuries to bones, joints, muscles and peripheral nerves. (euroasia-science.ru)
- In the somatic nervous system, the cranial nerves are part of the PNS with the exception of the optic nerve (cranial nerve II), along with the retina . (wikipedia.org)
- The somatic system includes the sensory nervous system and the somatosensory system and consists of sensory nerves and somatic nerves, and many nerves which hold both functions. (wikipedia.org)
- Although the importance of evaluating the distal sensory nerves has gained much attention, no study has addressed the issue whether NCS parameters of these distal sensory nerves in IGT patients are significantly different from those of healthy controls with no medical condition, and whether these parameters are different to those with patients with diabetes mellitus, who have no previous history of peripheral polyneuropathy. (bioportfolio.com)
- Peripheral nerves may be involved by Guillain-Barre, and Chr Inflammatory Polyneuritis. (healthtap.com)
- Pertinent cases are reported, to illustrate the effect of impairment of this blood supply in producing ischemia of the brain, spinal cord, and peripheral nerves. (biomedsearch.com)
- The autonomic nervous system is divided into sympathetic and parasympathetic nerves. (livestrong.com)
- However, David S. Goldstein, M.D., of the National Institute of Neurological Disorders and Stroke has reported that Parkinson's disease also damages sympathetic nerves to the heart. (livestrong.com)
- A neurological surgeon is a physician who surgically treats disorders of the nervous system, which is comprised of the brain, spinal cord and nerves. (vitals.com)
- HIV can cause damage to both the central nervous system the brain and spinal cord and the peripheral nervous system the nerves leading to and from the central nervous system. (healthcommunities.com)
- If the HIV infection affects the peripheral nervous system, then the nerves and muscles show various signs of dysfunction. (healthcommunities.com)
- In many cases, the first apparent symptom of POEMS syndrome is disease affecting many nerves (polyneuropathy). (rarediseases.org)
- The peripheral nervous system consists of all the motor and sensory (sensorimotor) nerves that connect the brain and spinal cord to the rest of the body (i.e., the nerves outside the central nervous system). (rarediseases.org)
- any disease or disorder of the nerves. (thefreedictionary.com)
- Substance P is produced in both the central nervous system (CNS) - the brain and spinal cord - and in our peripheral nervous system (PNS) - all the other nerves and nerve cells that send signals to the brain. (medicalxpress.com)
- Andermann syndrome, also known as agenesis of corpus callosum with neuronopathy (ACCPN) and Charlevoix disease, among other names, is a very rare neurodegenerative genetic disorder that damages the nerves used to control muscles and related to sensation and is often associated with agenesis of the corpus collosum. (wikipedia.org)
- This occurs by axonal disease paralyzing the skeletal muscles, including the respiratory muscles as a result of axonal damage in peripheral nerves. (wikipedia.org)
- The nerves connect to the peripheral nervous system. (wikipedia.org)
Autonomic10
- This targeted FOA specifically seeks to generate scientific advancements addressing the role of the autonomic nervous system in the regulation of peripheral metabolism and its role in diabetes, obesity and related metabolic disease. (nih.gov)
- Interdisciplinary teams may propose to develop resources in the form of novel tools or methodologies that when applied to the autonomic nervous system will contribute to elucidating its functional role in metabolism. (nih.gov)
- Alternatively, teams may focus on novel approaches to address specific knowledge gaps or scientific questions that will significantly contribute to our understanding of role of the autonomic nervous system in metabolism with the goal of accelerating scientific progress in the treatment and prevention of metabolic disease. (nih.gov)
- Manifestations of dysfunction of small autonomic fibers may include, among others, impaired sweating, gastrointestinal dysmotility, and abnormal Background: Fabry disease is an inherited metabolic disorder characterized by progressive lysosomal accumulation of lipids in a variety of cell types, including neural cells. (uni-wuerzburg.de)
- The peripheral nervous system is divided into the somatic nervous system and the autonomic nervous system . (wikipedia.org)
- [4] The autonomic nervous system is an involuntary control of smooth muscle and glands . (wikipedia.org)
- The autonomic nervous system is a 'self-regulating' system which influences the function of organs outside voluntary control, such as the heart rate , or the functions of the digestive system . (wikipedia.org)
- It can affect the feeling of your hands and feet and less often after very prolonged diabetes can affect your autonomic nervous system and lead to stomach problems or syncopal issues. (healthtap.com)
- The autonomic nervous system (ANS) controls automatic body functions such as heart rate, blood pressure, bowel, bladder and sexual function. (bidmc.org)
- Diabetes and Parkinson's disease are two examples of chronic conditions that can lead to autonomic dysfunction. (bidmc.org)
Neuropathies3
- The aim of this review is to evaluate the available data on clinical manifestations, pathogenesis , investigations and the therapeutic implication for peripheral nervous system [PNS] neuropathies complications of HIV / AIDS . (bvsalud.org)
- WHO HQ Library catalog › Results of search for 'su:{Nervous system diseases} and au:WHO Study Group on Peripheral Neuropathies. (who.int)
- Because of the accessibility of the peripheral nervous system (PNS) to direct physiological and pathological study, neuropathies have traditionally played a unique role in developing our understanding of basic mechanism of nervous system injury and repair. (nih.gov)
Spinal9
- The spinal cord as organizer of disease processes: II. (jaoa.org)
- This peripheral nervous diseases affect the sensory, motor and the relay neurons which are responsible for sensing and transferring of information from the spinal cord to the brain and vice versa. (howtohint.com)
- This work records the results of a study of the spinal cords, spinal sensory ganglia, sympathetic ganglia, Gasserian ganglia and neurones in the adrenal glands of sheep affected with scrapie disease. (ed.ac.uk)
- The central nervous system consists of the brain and spinal cord. (medicalnewstoday.com)
- We will look at the types of cells involved, different regions within the brain, spinal circuitry, and how the CNS can be affected by disease and injury. (medicalnewstoday.com)
- The sensory nervous system is part of the somatic nervous system and transmits signals from senses such as taste and touch (including fine touch and gross touch) to the spinal cord and brain. (wikipedia.org)
- Barkhof's research interests focus on childhood white matter disease, multiple sclerosis (spinal cord MRI, gray matter, atrophy, and histopathology correlations), aging (white matter lesions and microbleeds), and dementia (structural, functional, and molecular MR and PET). (springer.com)
- Any of various diseases involving the brain, spinal cord, and peripheral nervous system. (dictionary.com)
- According to Tim Newman, the central nervous system is made up of the brain and spinal cord, it collects information from the entire body and it also controls functions throughout the entire body. (wikipedia.org)
Diagnosis4
- A thorough physical examination (e. g., angiokeratoma, corneal opacities) and simple non-invasive sensory perception tests could provide clues to the diagnosis of Fabry disease. (uni-wuerzburg.de)
- Diagnosis is most often made by the elimination of other conditions, disorders or diseases. (wikipedia.org)
- Cerebrospinal fluid analysis (CSF) can be extremely beneficial in the diagnosis of central nervous system infections. (wikipedia.org)
- Diagnosis of peripheral nerve injuries is based on the history and clinical assessment of the motor and sensory function of the affected nerve(s). (merckvetmanual.com)
Clinical9
- Further developments in gene therapy would allow the progression and optimization of future applications regarding vector tools, therapeutic constructs, delivery systems, design of preclinical evaluation and clinical trials. (frontiersin.org)
- The aim of this Research Topic is to present the state of the art of gene therapy for neurological diseases from a clinical perspective, and address most key aspects representing the current focus of research of the international scientific community. (frontiersin.org)
- The clinical course of peripheral pain is summarized, and the importance of medical history-taking, including family history, is highlighted. (uni-wuerzburg.de)
- Objectives In a multi‐ethnic/racial, prospective SLE inception cohort, to determine the frequency, clinical characteristics, associations and outcomes in different types of peripheral nervous system (PNS) disease. (ucl.ac.uk)
- Infant Botulism Treatment and Prevention Program Official sites for physicians to obtain BabyBIG, an FDA approved orphant drug for treatment of infant botulism type A and B. Also provides parent support forum and medical/clinical information on the disease. (inter.rs)
- the frequencies of the symptom both as an initial sign and as observed during the clinical course of the disease were examined. (biomedsearch.com)
- It is therefore possible that the extent of NK T cell alteration may be a critical factor which would define the clinical and pathological features of autoimmune disease. (jimmunol.org)
- In close collaboration with the Department of Neuroradiology (www.klinikum.uni-heidelberg.de/MR-Neurographie.116270.0.html), we aim at defining more sensitive diagnostic parameters to detect lesions to the peripheral nervous system at possibly early stages of the disease and to predict response to different therapeutic options as well as to the clinical outcome more reliably. (uni-heidelberg.de)
- Autopsy examination of 8 cases has shown both developmental and degenerative neuropathologic features in this disease, consistent with clinical duality as both a neurodevelopmental and neurodegenerative disorder. (wikipedia.org)
Multiple sclerosis6
- In the most well known example of demyelinating disease, multiple sclerosis , evidence has shown that the body's own immune system is at least partially responsible. (wikipedia.org)
- As has been argued, diseases such as multiple sclerosis cannot be accounted for by autoimmune deficiency alone, but strongly imply the influence of flawed developmental processes in disease pathogenesis. (wikipedia.org)
- Fatigue is intrinsic to Multiple Sclerosis (MS) and represents the most common symptom experienced by patients along the course of the disease [ 1 ], contributing to disability and to the worsening of their daily quality of life [ 2 , 3 ]. (hindawi.com)
- A new study suggests that patients with relapsing-remitting multiple sclerosis can experience long-term increases in disability in the absence of disease relapses. (nature.com)
- Using a single-strand conformation polymorphism method, we demonstrate that a great reduction of Vα24JαQ NK T cells in the peripheral blood is an immunological hallmark of multiple sclerosis, whereas it is not appreciable in other autoimmune/inflammatory diseases such as chronic inflammatory demyelinating polyneuropathy. (jimmunol.org)
- For example, Multiple Sclerosis (MS) is an inflammatory neurodegenerative disease, where the body initiate an inflammatory reaction in the central nervous system, and causes damage to neurons. (wikipedia.org)
Symptoms7
- Workers reported symptoms that predominantly involved central (CNS) and peripheral (PNS) nervous systems. (ilo.org)
- Symptoms and signs that present in demyelinating diseases are different for each condition. (wikipedia.org)
- Mayoclinic.com notes that Parkinson's disease is primarily associated with motor nerve disruptions that cause symptoms such as tremors, loss of balance control and slowed movement. (livestrong.com)
- Alzheimer's Disease Facts about Alzheimer's Disease, including the symptoms and stages. (vitals.com)
- In HIV patients and other people with suppressed immune systems, however, the bacteria can cause brain abscess (tissue damage and the accumulation of pus) the symptoms of which vary depending on the location of the infection in the brain. (healthcommunities.com)
- Peripheral neuropathic pain often includes symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity to normally painful stimuli. (mendeley.com)
- Given the significance of the nervous system in human physiology, symptoms can involve other organ systems and result in motor dysfunction, sensory impairment, pain, etc. (wikipedia.org)
Infectious Diseases3
- Libyan Journal of Infectious Diseases [The]. (bvsalud.org)
- This development of an innovative method to enhance the immune system for the treatment of infectious diseases is similar to vaccinations without the side effects. (kalinka-store.com)
- Thus, here is a real mechanism for an excellent and effective strategy against infectious diseases. (kalinka-store.com)
Sensory1
- Diabetic Peripheral polyneuropathy (DPP) presents as a slowly progressive primary sensory deficit in length dependent fashion, to result in the classic stocking glove distribution. (bioportfolio.com)
Neurons9
- centrencephalic system the neurons in the central core of the brainstem from the thalamus to the medulla oblongata, connecting the cerebral hemispheres . (thefreedictionary.com)
- Thanks to flow of rhythm regulated afferent electric pulsation created during the procedure neurons of posterior horns substantia gelatinosa are stimulated, and their perception of nocigenic (pain) information coming from pathology center through thing non-myelinated nervous fibers with low velocity of pulses conducting is blocked. (denasms.com)
- primarily will effect these peripheral, it will only effect these peripheral neurons. (coursera.org)
- A demyelinating disease is any disease of the nervous system in which the myelin sheath of neurons is damaged. (wikipedia.org)
- Demyelinating diseases are a group of disorders of the nervous system that involve loss of the myelin sheath that normally surrounds the neurons. (nature.com)
- This is in direct contrast to its role in the central nervous system, where it triggers very different signals, exciting neurons and so promoting pain. (medicalxpress.com)
- Substance P works in the peripheral system by modulating the action of certain proteins that control the ability of pain-sensing neurons to respond to 'painful' stimuli. (medicalxpress.com)
- A neurodegenerative disease is a disease that causes damage to neurons. (wikipedia.org)
- On the other hand, Parkinson's Disease results from damage of neurons in the Substantia Nigra, which is important to initiate motor behavior. (wikipedia.org)
Patients24
- Mud therapy may have therapeutic value in reducing inflammation and improving the immune status of patients with traumas of the peripheral nervous system. (greenmedinfo.com)
- to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. (jcdr.net)
- Methods: An international expert panel convened with the goal to provide guidance to clinicians who may encounter unrecognized patients with Fabry disease on how to diagnose these patients early using simple diagnostic tests. (uni-wuerzburg.de)
- This is particularly important since management of pain in young patients with Fabry disease appears to be inadequate. (uni-wuerzburg.de)
- Methods Patients were evaluated annually for 19 neuropsychiatric (NP) events including seven types of PNS disease. (ucl.ac.uk)
- Since antibodies against peripheral nervous system (PNS) antigens may play a pathogenetic role in the mechanism of nerve damage in leprosy, sera from leprosy patients and contacts were investigated for anti-PNS antibodies by ELISA and immunoblot. (ilsl.br)
- The main objective of this research is to optimize pain treatment with patients with occupation-conditioned diseases of the locomotor system (LMS) and the peripheral nervous system (PNS). (euroasia-science.ru)
- The patients of this research were hospitalized in the Department of Occupational Diseases, UMHAT "Dr. Georgi Stranski"- Pleven, during the period 2014-2016. (euroasia-science.ru)
- The aim of the study is to optimize the treatment of pain in patients with work related diseases of the bones-joints and peripheral nervous system. (euroasia-science.ru)
- Those who have been diagnosed with complex diseases, such patients also receive high-end diagnostic examination and rehabilitation measures. (placidway.com)
- We conducted a phase 3, open-label trial involving patients with HER2-positive early breast cancer who were found to have residual invasive disease in the breast or axilla at surgery after receiving neoadjuvant therapy containing a taxane (with or without anthracycline) and trastuzumab. (nih.gov)
- The estimated percentage of patients who were free of invasive disease at 3 years was 88.3% in the T-DM1 group and 77.0% in the trastuzumab group. (nih.gov)
- Distant recurrence as the first invasive-disease event occurred in 10.5% of patients in the T-DM1 group and 15.9% of those in the trastuzumab group. (nih.gov)
- Among patients with HER2-positive early breast cancer who had residual invasive disease after completion of neoadjuvant therapy, the risk of recurrence of invasive breast cancer or death was 50% lower with adjuvant T-DM1 than with trastuzumab alone. (nih.gov)
- There is recent evidence to indicate that patients with impaired glucose tolerance ( IGT) on OGTT, the prediabetic stage, have three times the prevalence of distal peripheral polyneuropathy than age matched controls. (bioportfolio.com)
- In patients with such neurologic disease, especially if sudden in onset, a search for a circulatory basis in lesions of the aorta or its branches may be rewarding and crucial. (biomedsearch.com)
- Cook treats patients with diseases affecting the central or peripheral nervous system. (courant.com)
- Tai chi chuan exercise improves fasting blood glucose and peripheral nerve conduction velocities in type 2 diabetic patients. (greenmedinfo.com)
- Determine the change in peripheral nerve function in cancer patients during and after treatment with chemotherapy or biologic therapy. (knowcancer.com)
- Patients undergo a 1-hour peripheral nerve function assessment, including hearing, vibratory sensation, and blood pressure testing, at baseline and then at 4, 8, and 12 weeks during treatment with chemotherapy or biologic therapy. (knowcancer.com)
- The most common central nervous system disorder in HIV patients is the infection toxoplasmosis, followed by HIV-related brain cancer. (healthcommunities.com)
- Cerebral toxoplasmosis, also known simply as toxoplasmosis, is the most common central nervous system infection in HIV patients. (healthcommunities.com)
- Central nervous system lymphoma is the second most common nervous system abnormality in HIV patients. (healthcommunities.com)
- TPD significantly attenuated TACE-mediated disease models of sepsis, rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), and reduced TNFa in synovial fluids from RA patients. (weizmann.ac.il)
Neurologic disease2
Etiology1
- Most of the large envelope-bearing viruses that figured prominently in older series of ADEM, of which measles was a particularly virulent example, no longer figure importantly in the etiology of ADEM because these diseases are prevented by vaccination. (medscape.com)
Chronic5
- Targeting central pathways implicated in complex disease mechanisms (neurodegeneration, consequences of traumatic injury, chronic pain). (frontiersin.org)
- Peripheral pain can be chronic and/or occur as provoked attacks of excruciating pain. (uni-wuerzburg.de)
- Their wellness and therapeutic programs not just treat severe chronic diseases, but also provide rejuvenation and prevention of aging. (placidway.com)
- Individuals with POEMS syndrome experience chronic, progressive disease affecting the peripheral nervous system. (rarediseases.org)
- whereas, MS is typically a chronic relapsing and remitting disease of young adults. (medscape.com)
Involvement1
- This case appears unique for the type of histologically documented cardiac and neurological parenchymal involvement, and at the same time, exemplifies the subtle and pernicious course of the disease. (springer.com)
Affects5
- It is important for to know how to overcome your peripheral nervous system disease since it is one of the disease which affects many people and you need to share with people you trust. (howtohint.com)
- NHS Choices: Neurofibromatosis Provides information on this genetic disorder that affects the nervous system and the skin. (inter.rs)
- Which autpimmune disease affects the nervous system? (healthtap.com)
- POEMS syndrome affects multiple organ systems of the body. (rarediseases.org)
- While most nervous system diseases affect either CNS or PNS, this disease affects both, but it is the changes in the peripheral nervous system that lead to death. (wikipedia.org)
Pathogenesis2
- These findings provide new insights on the molecular mechanisms of Krabbe disease, representing a starting point for future functional experiments to study the molecular pathogenesis of Krabbe disease. (nih.gov)
- [12] Therefore, the role of the human-specific prolonged period of cortical myelination is an important evolutionary consideration in the pathogenesis of demyelinating disease. (wikipedia.org)
Demyelination3
- The major effect of GALC deficiency is the accumulation of psychosine in the nervous system and widespread degeneration of oligodendrocytes and Schwann cells, causing rapid demyelination. (nih.gov)
- More than 400 protein groups exhibited differences in expression and included proteins involved in pathways that can be linked to Krabbe disease, such as inflammatory and defense response, lysosomal proteins accumulation, demyelination, reduced nervous system development and cell adhesion. (nih.gov)
- Neurodegneration is different in each disease, for example, MS is a result of a degenerative process called demyelination. (wikipedia.org)
Autoimmune Diseases6
- Which autoimmune diseases affect the nervous system? (healthtap.com)
- Because they can rapidly produce large amounts of regulatory cytokines, a reduction of NK T cells may lead to the development of certain autoimmune diseases. (jimmunol.org)
- Although a requirement of NK T cells for a Th2 immune response is not absolute ( 13 , 14 ), accumulating evidence supports the role of NK T cells in the regulation of autoimmune diseases ( 15 , 16 , 17 , 18 , 19 , 20 ). (jimmunol.org)
- It has recently been reported that NK T cells may be numerically or functionally altered in certain autoimmune diseases. (jimmunol.org)
- A decreased number of NK T cells was demonstrated in human systemic sclerosis ( 15 ), insulin-dependent diabetes mellitus ( 16 ), and spontaneous autoimmune diseases in rodents ( 17 , 18 , 19 ). (jimmunol.org)
- Moreover, none of the studies have addressed whether NK T cells may participate in the local regulation of autoimmune diseases. (jimmunol.org)
20161
- The subject is 58 people hospitalized in the Department of Occupational Diseases, University Hospital - Pleven in 2014-2016. (euroasia-science.ru)
Musculoskeletal system1
- All musculoskeletal system and peripheral nervous system diseases and traumatic injuries in acute period are characterized by acute pain, edema, soft tissues hemorrhage, extravasations and infusions into joint cavity, inflammatory reaction and dysfunction. (denasms.com)
Axon2
- If you cut a, an axon in the peripheral nervous system, it can repair itself. (coursera.org)
- Peripheral Nerve Diffusion Tensor Imaging: Assessment of Axon and Myelin Sheath Integrity. (uni-heidelberg.de)
Neurodegenerative diseases2
- Unlike other primates, humans exhibit a unique pattern of postpubertal myelination, which may contribute to the development of psychiatric disorders and neurodegenerative diseases that present in early adulthood and beyond. (wikipedia.org)
- It has been previously speculated that injury-induced degeneration ( Wallerian degeneration) shares some molecular features with `dying back' neurodegenerative diseases. (weizmann.ac.il)
Infection5
- In the peripheral nervous system, B. burgdorferi infection is associated with mononeuritis multiplex and polyradiculoneuritis. (medconditions.net)
- It invades and impairs the body's immune system parts and processes of the body that fight disease and infection. (healthcommunities.com)
- Features an abstract that discuss how toxic and infection impedes the development of the nervous system. (botw.org)
- Polyneuropathies are highly prevalent and represent the most common neurological sequelae in many systemic disorders such as diabetes, alcoholism, HIV or hepatitis infection, leukemia and other oncological diseases. (uni-heidelberg.de)
- For example, meningitis is a common infection of the central nervous system, where bacterial or viral infections cause an inflammation of the meninges. (wikipedia.org)
Inflammatory2
- A case-control study of the prevalence of neurological diseases in inflammatory bowel disease (IBD). (uams.edu)
- Peripheral nerve disorders encompass a spectrum of heterogeneous disorders of inflammatory, toxic, degenerative or metabolic origin. (uni-heidelberg.de)
Lesions1
- Acquired immune system cells called T-cells are known to be present at the site of lesions. (wikipedia.org)
Disorders of the nervous system1
- Peripheral nerve diseases are among the most prevalent disorders of the nervous system. (nih.gov)
Digestive2
- alimentary system digestive system . (thefreedictionary.com)
- Which diseases affect the respiratory, circulatory and digestive system? (healthtap.com)
Affect the nervous system4
- Amyloidosis , is a rare but severe complication and can affect the nervous system. (healthtap.com)
- Diabetes can affect the nervous system but the cause of diabetes is not the nervous system. (healthtap.com)
- Does Lyme disease affect the nervous system? (healthtap.com)
- Pathogens like fungi, bacteria, and viruses can affect the nervous system. (wikipedia.org)
Neurological diseases1
- In the last two decades, gene therapy has made considerable achievements, particularly in the field of neurological diseases. (frontiersin.org)
Alzheimer's Disease1
- Examples of neurodegenerative disease include Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis. (wikipedia.org)
Endocrine3
- For example, the collection of glands in the endocrine system can be thought of as a system, each endocrine gland could be viewed as a system, or even specific cells of a single gland could be studied as a system. (thefreedictionary.com)
- It is also possible to think of the human body as a living system and the endocrine system as a subsystem. (thefreedictionary.com)
- Individuals with POEMS syndrome may exhibit various abnormalities affecting the endocrine system (i.e., the system of glands that secrete hormones into the blood system). (rarediseases.org)
Genetic4
- This concerned genetic (particularly lysosomal diseases) but also complex multifactorial disorders (Parkinson and Alzheimer's diseases). (frontiersin.org)
- Are most nervous system diseases genetic? (healthtap.com)
- Homology closed out the year by nominating development candidates for two additional programs focused on pediatric rare genetic diseases, both of which have entered into IND-enabling studies. (yahoo.com)
- Some nervous system diseases are due to genetic mutations. (wikipedia.org)
Neuropathic pain2
- Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. (mendeley.com)
- Neuropathic pain is a common symptom in many diseases of the peripheral nervous system. (mendeley.com)
Abnormalities3
- Conclusion: Our findings demonstrate the absence of significant functional, structural, or compositional abnormalities in the peripheral nervous system of the murine model for Sandhoff disease, but do show the potential value of integrating multiple techniques to evaluate myelin structure and function in nervous system disorders. (harvard.edu)
- Any of various diseases or abnormalities of the nervous system, especially of the peripheral nervous system. (thefreedictionary.com)
- For example, Anencephaly (or spina bifida) causes abnormalities in the nervous system due to neural tube defects. (wikipedia.org)
Dysfunction1
- The immediate effect of injury of a peripheral nerve is a variable degree of dysfunction, depending on the severity of the injury. (merckvetmanual.com)
Parkinson's Disease3
- Diseases that affect this area include Parkinson's disease and Huntington's disease . (medicalnewstoday.com)
- Parkinson's disease is a nervous system disorder whose origins remain unclear. (livestrong.com)
- In Parkinson's disease, the brain produces inadequate amounts of dopamine, and protein masses called Lewy bodies form in the brain. (livestrong.com)
Diabetes1
- Is diabetes a nervous system disease? (healthtap.com)
Therapeutic3
- The efficacy of gene therapy tools such as viral vectors, serotypes and therapeutic cassettes, the delivery systems manufacturing and quality control. (frontiersin.org)
- find that regeneration of CNS myelin requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state, revealing new therapeutic targets for neurodegenerative disease. (nature.com)
- This report is representative of the neurological and cardiac changes described in the literature for IgG4-related disease, which may be correlated or not with the renal form and highlights the need, in some cases, of targeted therapeutic approaches. (springer.com)
Centers for Diseas4
- Centers for Disease Control and Prevention. (cdc.gov)
- The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
- The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
- Saving Lives, Protecting People Centers for Disease Control and Prevention. (cdc.gov)
Krabbe3
- Krabbe disease is a rare, childhood lysosomal storage disorder caused by a deficiency of galactosylceramide beta-galactosidase (GALC). (nih.gov)
- The molecular mechanisms of Krabbe disease are not yet fully elucidated and a definite cure is still missing. (nih.gov)
- Here we report the first in-depth characterization of the proteome of the Twitcher mouse, a spontaneous mouse model of Krabbe disease, to investigate the proteome changes in the Central and Peripheral Nervous System. (nih.gov)
Rheumatoid2
- Are you referring to autoimmune types of connective tissue diseases, such as rheumatoid or psoriatic arthritis ? (healthtap.com)
- Can untreated rheumatoid arthritis cause nervous system damage or problems with the nervous system? (healthtap.com)
Cranial2
- The second cranial nerve is not a true peripheral nerve but a tract of the diencephalon . (wikipedia.org)
- A general term indicating inflammation of a peripheral or cranial nerve. (curehunter.com)
Sympathetic nervou1
- The sympathetic nervous system regulates blood flow and perspiration. (livestrong.com)
Methods2
- This JAX course will focus on the use of the innovative tools and methods, specifically in the laboratory mouse, for answering questions of neuron and circuit function and disease mechanisms during neurodegeneration. (jax.org)
- A natural substance known to activate pain in the central nervous system has been found to have the opposite effect in other parts of the body, potentially paving the way to new methods of pain control. (medicalxpress.com)
Lysosomal2
- Background: Sandhoff disease is an inherited lysosomal storage disease caused by a mutation in the gene for the β-subunit (Hexb gene) of β-hexosaminidase A (αβ) and B (ββ). (harvard.edu)
- Background: Fabry disease is an inherited metabolic disorder characterized by progressive lysosomal accumulation of lipids in a variety of cell types, including neural cells. (uni-wuerzburg.de)
Body's3
- The nervous system is the body's most well-organized and complex structural and functional system. (howtohint.com)
- But we've discovered a paradox - that in the peripheral nervous system it acts as one of the body's natural painkillers and actually suppresses pain. (medicalxpress.com)
- Drugs like morphine hijack the body's natural painkilling mechanisms, such as those used by endorphins, but because they act within the central nervous system, they can affect other brain cells that use similar pathways, leading to side effects such as addiction or sleepiness," says Professor Gamper. (medicalxpress.com)