Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.
An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, usually causing an inapparent intestinal infection in mice. A small number of mice may show signs of flaccid paralysis.
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.
The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.
The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during mitosis.
Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)
The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Renewal or physiological repair of damaged nerve tissue.
Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Characteristic properties and processes of the NERVOUS SYSTEM as a whole or with reference to the peripheral or the CENTRAL NERVOUS SYSTEM.
A protein that accounts for more than half of the peripheral nervous system myelin protein. The extracellular domain of this protein is believed to engage in adhesive interactions and thus hold the myelin membrane compact. It can behave as a homophilic adhesion molecule through interactions with its extracellular domains. (From J Cell Biol 1994;126(4):1089-97)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Injuries to the PERIPHERAL NERVES.
Elements of limited time intervals, contributing to particular results or situations.
The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)
MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.
Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.
An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.
Regularly spaced gaps in the myelin sheaths of peripheral axons. Ranvier's nodes allow saltatory conduction, that is, jumping of impulses from node to node, which is faster and more energetically favorable than continuous conduction.
Postmortem examination of the body.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
A subclass of closely-related SOX transcription factors. Members of this subfamily have been implicated in regulating the differentiation of OLIGODENDROCYTES during neural crest formation and in CHONDROGENESIS.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures.
An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.
Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.
Specialized organs adapted for the reception of stimuli by the NERVOUS SYSTEM.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.
Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.
Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.
Twelve pairs of nerves that carry general afferent, visceral afferent, special afferent, somatic efferent, and autonomic efferent fibers.
Specialized afferent neurons capable of transducing sensory stimuli into NERVE IMPULSES to be transmitted to the CENTRAL NERVOUS SYSTEM. Sometimes sensory receptors for external stimuli are called exteroceptors; for internal stimuli are called interoceptors and proprioceptors.
A branch of the tibial nerve which supplies sensory innervation to parts of the lower leg and foot.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Neurons which activate MUSCLE CELLS.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.
Drugs that act principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system. (From Smith and Reynard, Textbook of Pharmacology, 1991, p75)
Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Clusters of multipolar neurons surrounded by a capsule of loosely organized CONNECTIVE TISSUE located outside the CENTRAL NERVOUS SYSTEM.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An early growth response transcription factor that controls the formation of the MYELIN SHEATH around peripheral AXONS by SCHWANN CELLS. Mutations in EGR2 transcription factor have been associated with HEREDITARY MOTOR AND SENSORY NEUROPATHIES such as CHARCOT-MARIE-TOOTH DISEASE.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.
An infant during the first month after birth.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Mice which carry mutant genes for neurologic defects or abnormalities.
In tissue culture, hairlike projections of neurons stimulated by growth factors and other molecules. These projections may go on to form a branched tree of dendrites or a single axon or they may be reabsorbed at a later stage of development. "Neurite" may refer to any filamentous or pointed outgrowth of an embryonal or tissue-culture neural cell.
Clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons. Sensory ganglia may also have intrinsic interneurons and non-neuronal supporting cells.
A group of disorders characterized by an autosomal dominant pattern of inheritance with high rates of spontaneous mutation and multiple neurofibromas or neurilemmomas. NEUROFIBROMATOSIS 1 (generalized neurofibromatosis) accounts for approximately 95% of cases, although multiple additional subtypes (e.g., NEUROFIBROMATOSIS 2, neurofibromatosis 3, etc.) have been described. (From Neurochirurgie 1998 Nov;44(4):267-72)
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Catalyzes the final step in the galactocerebroside biosynthesis pathway.
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
A species of fruit fly much used in genetics because of the large size of its chromosomes.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
A general term indicating inflammation of a peripheral or cranial nerve. Clinical manifestation may include PAIN; PARESTHESIAS; PARESIS; or HYPESTHESIA.
The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.
The functional hereditary units of INSECTS.
Infections of the BRAIN; SPINAL CORD; or MENINGES caused by HELMINTHS (parasitic worms).
The medial terminal branch of the sciatic nerve. The tibial nerve fibers originate in lumbar and sacral spinal segments (L4 to S2). They supply motor and sensory innervation to parts of the calf and foot.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Treatment of muscles and nerves under pressure as a result of crush injuries.
The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.
Differentiated tissue of the central nervous system composed of NERVE CELLS, fibers, DENDRITES, and specialized supporting cells.
Refers to animals in the period of time just after birth.
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

Unsuccessful surgical treatment of hip dislocation in congenital sensory neuropathy with anhidrosis. A case report. (1/1736)

A six-year-old girl with congenital sensory neuropathy with anhidrosis (CSNA) presented with bilateral hip dysplasia and subluxation on the right side. Conservative treatment of the hips by closed reduction and a plaster cast was unsuccessful. When aged seven years the patient had an intertrochanteric varus rotation osteotomy on the right side, but subluxation was again evident after five months. A Salter-type pelvic osteotomy was carried out followed by immobilisation, but one year later subluxation was present in the right hip and dislocation in the left. At the age of nine years, the right femoral head resembled a Charcot joint, although walking ability was preserved. In patients with CSNA, surgery may not always be advisable.  (+info)

Phase II study of cisplatin and vinorelbine as first-line chemotherapy in patients with carcinoma of the uterine cervix. (2/1736)

PURPOSE: To evaluate the activity and toxicity of the combination of cisplatin (80 mg/m2 day 1) and vinorelbine (25 mg/m2 days 1 and 8) in patients with carcinoma of the uterine cervix that has not been previously treated with chemotherapy. PATIENTS AND METHODS: Fifty patients with cervical cancer were enrolled onto this study (27 stage IB-III, 23 stage IVB-recurrent). A two-stage optimal Simon design was applied. Thirteen responders of 29 treated patients were required to proceed beyond the first stage, and 28 responders were needed overall. RESULTS: Hematologic toxicity was mild, with neutropenia being the most frequent side effect. Nonhematologic toxicity was frequent but never severe; one patient had grade 3 peripheral neurotoxicity. Objective responses were recorded for 32 patients (64%): 11 patients (22%) achieved a complete response (CR) and 21 patients (42%) achieved a partial response (PR). The response rate was 81.5% in patients with IB-III stage (25.9% CR rate) and 43.5% in patients with IVB-recurrent disease (17.4% CR rate). Responses were seen both in stage IVB patients (one CR and two PRs, for an overall rate of 37.5%) and in patients with recurrent disease (three CRs + four PRs, for an overall rate of 46.7%). CONCLUSION: The combination of cisplatin and vinorelbine is an active regimen in the treatment of patients with early-stage and advanced carcinoma of the uterine cervix. The hematologic and nonhematologic toxicity of this combination is mild.  (+info)

Clinicopathological features of Churg-Strauss syndrome-associated neuropathy. (3/1736)

We assessed the clinicopathological features of 28 patients with peripheral neuropathy associated with Churg-Strauss syndrome. Initial symptoms attributable to neuropathy were acute painful dysaesthesiae and oedema in the dysaesthetic portion of the distal limbs. Sensory and motor involvement mostly showed a pattern of mononeuritis multiplex in the initial phase, progressing into asymmetrical polyneuropathy, restricted to the limbs. Parallel loss of myelinated and unmyelinated fibres due to axonal degeneration was evident as decreased or absent amplitudes of sensory nerve action potentials and compound muscle action potentials, indicating acute massive axonal loss. Epineurial necrotizing vasculitis was seen in 54% of cases; infiltrates consisted mainly of CD8-positive suppressor/cytotoxic and CD4-positive helper T lymphocytes. Eosinophils were present in infiltrates, but in smaller numbers than lymphocytes. CD20-positive B lymphocytes were seen only occasionally. Deposits of IgG, C3d, IgE and major basic protein were scarce. The mean follow-up period was 4.2 years, with a range of 8 months to 10 years. Fatal outcome was seen only in a single patient, indicating a good survival rate. The patients who responded well to the initial corticosteroid therapy within 4 weeks regained self-controlled functional status in longterm follow-up (modified Rankin score was < or = 2), while those not responding well to the initial corticosteroid therapy led a dependent existence (P < 0.01). In addition the patients with poor functional outcomes had significantly more systemic organ damage caused by vasculitis (P < 0.05). Necrotizing vasculitis mediated by cytotoxic T cells, leading to ischaemic changes, appears to be a major cause of Churg-Strauss syndrome-associated neuropathy. The initial clinical course and the extent of systemic vasculitic lesions may influence the long-term functional prognosis.  (+info)

Neurological complications of neurofibromatosis type 1 in adulthood. (4/1736)

Neurofibromatosis type 1 (NF1) is a genetic disease with a wide range of neurological manifestations. To examine these, and to evaluate neurological morbidity in adulthood of patients with NF1, we studied a hospital-based series of 158 patients that included 138 adult patients aged >18 years and 20 children. NF1 evaluation included a multidisciplinary clinical and a clinically oriented radiological investigation. Neurological events occurring during childhood (in both children and adults of the series) and adulthood were recorded. One or several neurological manifestations have been observed in 55% of patients (adults and children) (n = 87). These included: headache (28 patients); hydrocephalus (7); epilepsy (5); lacunar stroke (1); white matter disease (1); intraspinal neurofibroma (3); facial palsy (1); radiculopathy (5); and polyneuropathy (2). Tumours included: optic pathway tumours (20); meningioma (2); cerebral glioma (3); and malignant peripheral nerve sheath tumours (6). Life-threatening complications were observed in five adults and included four malignant peripheral nerve sheath tumours and one meningioma. Pain was the leading symptom in 11 adults and was related to malignant peripheral nerve sheath tumours, complications of intraspinal neurofibromas, subcutaneous neurofibromas and peripheral nerve neurofibromas. NF1 in adults was not associated with other disabling or life-threatening neurological complications. Symptomatic optic pathway tumours, cerebral gliomas, symptomatic aqueductal stenosis and spinal compression due to intraspinal NF were observed exclusively during childhood. In this series, the predominant neurological features of adults with NF1 were chronic pain and malignant peripheral nerve sheath tumours.  (+info)

Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data. (5/1736)

In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and kidney of affected cats revealed contamination with the ionophor salinomycin. Epidemiologic and clinical data were collected from 823 cats, or about 1% of the cats at risk. In 21 affected cats, postmortem examination was performed. The affected cats had acute onset of lameness and paralysis of the hindlimbs followed by the forelimbs. Clinical and pathologic examination indicated a distal polyneuropathy involving both the sensory and motor nerves.  (+info)

Ten- to 15-year outcome of surgery for lumbar disc herniation: radiographic instability and clinical findings. (6/1736)

The most appropriate treatment for radiculopathy associated with disc pathology is still controversial. Since 1934, surgical treatment has consisted of hemilaminectomy and removal of the herniated material. Many authors believe that these procedures may cause degenerative spondylosis and vertebral instability. Several surgical methods have been proposed, but the long-term effects are still being debated. In addition there appear to be few well-designed outcome studies on the management of this disease. In the present study, 150 patients were selected for surgery with strict criteria and all treated with the standard technique. The series was evaluated by subjective analyses (Roland questionnaire; 120 patients), objective examinations (68 patients - 56.6%) and radiographic studies including dynamic views (analyzed by the Taillard and Boxall methods) to establish the presence of vertebral instability (50 patients - 41.6%). The subjective and objective analyses showed a high rate of good results. Radiographic studies showed vertebral instability in 30 cases, but only 9 were symptomatic. Recurrences were not observed and only a few patients suffered from leg pain. The standard procedure for lumbar disc herniation showed good results at 10- and 15-year follow-up.  (+info)

Successful treatment of IgM paraproteinaemic neuropathy with fludarabine. (7/1736)

OBJECTIVES: To evaluate the response of four patients with IgM paraproteinaemic neuropathy to a novel therapy-pulsed intravenous fludarabine. BACKGROUND: The peripheral neuropathy associated with IgM paraproteinaemia usually runs a chronic, slowly progressive course which may eventually cause severe disability. Treatment with conventional immunosuppressive regimens has been unsatisfactory. Fludarabine is a novel purine analogue which has recently been shown to be effective in low grade lymphoid malignancies. METHODS: Four patients were treated with IgM paraproteinaemic neuropathy with intravenous pulses of fludarabine. Two of the four patients had antibodies to MAG and characteristic widely spaced myelin on nerve biopsy and a third had characteristic widely spaced myelin only. The fourth had an endoneurial lymphocytic infiltrate on nerve biopsy and a diagnosis of Waldenstrom's macroglobulinaemia. RESULTS: In all cases subjective and objective clinical improvement occurred associated with a significant fall in the IgM paraprotein concentration in three cases. Neurophysiological parameters improved in the three patients examined. The treatment was well tolerated. All patients developed mild, reversible lymphopenia and 50% mild generalised myelosuppression, but there were no febrile episodes. CONCLUSION: Fludarabine should be considered as a possible treatment for patients with IgM MGUS paraproteinaemic neuropathy.  (+info)

Vasculitic polyradiculopathy in systemic lupus erythematosus. (8/1736)

A 22 year old woman with recently diagnosed systemic lupus erythematosus presented with subacute progressive areflexic paraparesis, electrophysiologically identified as a pure axonal polyradiculopathy. Sural nerve biopsy disclosed necrotising vasculitis. A striking radiological feature was marked enhancement of the cauda equina with gadolinium.  (+info)

TY - JOUR. T1 - Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers. T2 - American society of clinical oncology clinical practice guideline. AU - Hershman, Dawn L.. AU - Lacchetti, Christina. AU - Dworkin, Robert H.. AU - Lavoie Smith, Ellen M.. AU - Bleeker, Jonathan. AU - Cavaletti, Guido. AU - Chauhan, Cynthia. AU - Gavin, Patrick. AU - Lavino, Antoinette. AU - Lustberg, Maryam B.. AU - Paice, Judith. AU - Schneider, Bryan. AU - Smith, Mary Lou. AU - Smith, Tom. AU - Terstriep, Shelby. AU - Wagner-Johnston, Nina. AU - Bak, Kate. AU - Loprinzi, Charles L.. PY - 2014/6/20. Y1 - 2014/6/20. N2 - Purpose: To provide evidence-based guidance on the optimum prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathies (CIPN) in adult cancer survivors. Methods: A systematic literature search identified relevant, randomized controlled trials (RCTs) for the treatment of CIPN. Primary outcomes included incidence and ...
TY - JOUR. T1 - Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy. T2 - Taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF. AU - Kirchmair, Rudolf. AU - Tietz, Anne B.. AU - Panagiotou, Eleftheria. AU - Walter, Dirk H.. AU - Silver, Marcy. AU - Yoon, Young Sup. AU - Schratzberger, Peter. AU - Weber, Alberto. AU - Kusano, Kengo. AU - Weinberg, David H.. AU - Ropper, Allan H.. AU - Isner, Jeffrey M.. AU - Losordo, Douglas W.. PY - 2007/1. Y1 - 2007/1. N2 - Toxic neuropathy represents an important clinical problem in the use of the chemotherapeutic substances Taxol and thalidomide. Sensory neuropathy has a high incidence, lacks an effective treatment and is the dose-limiting factor for these drugs. The pathogenic basis of these neuropathies is unknown. We investigated the hypothesis that the experimental toxic neuropathies from Taxol and thalidomide results from destruction of vasa nervorum and can be reversed by the administration of ...
Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a dose-limiting side effect of several antineoplastic drugs which significantly reduces patients quality of life. Although different molecular mechanisms have been investigated, CIPN pathobiology has not been clarified yet. It has largely been recognized that Dorsal Root Ganglia are the main targets of chemotherapy and that the longest nerves are the most damaged, together with fast axonal transport. Indeed, this bidirectional cargo-specific transport has a pivotal role in neuronal function and its impairment is involved in several neurodegenerative and neurodevelopmental diseases. Literature data demonstrate that, despite different mechanisms of action, all antineoplastic agents impair the axonal trafficking to some extent and the severity of the neuropathy correlates with the degree of damage on this bidirectional transport. In this paper, we will examine the effect of the main old and new chemotherapeutic drug categories on axonal transport, with
Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, enduring, and often irreversible condition featuring pain, numbness, tingling and sensitivity to cold in the hands and feet (sometimes progressing to the arms and legs) that afflicts between 30% and 40% of patients undergoing chemotherapy. Chemotherapy drugs associated with CIPN include thalidomide, the epothilones such as ixabepilone, the vinca alkaloids vincristine and vinblastine, the taxanes paclitaxel and docetaxel, the proteasome inhibitors such as bortezomib, and the platinum-based drugs cisplatin, oxaliplatin and carboplatin. Whether CIPN arises, and to what degree, is determined by the choice of drug, duration of use, the total amount consumed and whether the patient already has peripheral neuropathy. Though the symptoms are mainly sensory - pain, tingling, numbness and temperature sensitivity - in some cases motor nerves are affected, and occasionally, also, the autonomic nervous system. CIPN often follows the first ...
To update the ASCO guideline on the recommended prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathy (CIPN) in adult cancer survivors.An Expert Panel conducted targeted systematic literature reviews to identify new studies.The search strategy identified 257 new references, which led to a full-text review of 87 manuscripts. A total of 3 systematic reviews, 2 with meta-analyses, and 28 primary trials for prevention of CIPN in addition to 14 primary trials related to treatment of established CIPN, are included in this update.The identified data reconfirmed that no agents are recommended for the prevention of CIPN. The use of acetyl-l-carnitine for the prevention of CIPN in patients with cancer should be discouraged. Furthermore, clinicians should assess the appropriateness of dose delaying, dose reduction, substitutions, or stopping chemotherapy in patients who develop intolerable neuropathy and/or functional impairment. Duloxetine is the only agent ...
Chemotherapy-induced peripheral neuropathy (CIPN), a debilitating major side-effect of malignancy treatment, is definitely seen as a pain and sensory loss at hand and feet. mitochondrial accumulation of p53 in dorsal root ganglia (DRG), spinal cord, and peripheral nerve without evidence for apoptosis. Cisplatin-treatment also reduced mitochondrial membrane potential and lead to abnormal mitochondrial morphology and impaired mitochondrial function in DRG neurons. Pre-treatment with PFT- prevented the early cisplatin-induced increase in mitochondrial p53 and the reduction in mitochondrial membrane potential. Inhibition of the early mitochondrial p53 accumulation by PFT- also prevented the abnormalities buy 936563-96-1 in mitochondrial morphology and mitochondrial bioenergetics (reduced oxygen consumption rate, maximum respiratory capacity, and adenosine triphosphate synthesis) that develop in DRG and peripheral nerve after cisplatin-treatment. Functionally, inhibition of mitochondrial p53 ...
INTRODUCTION: Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and clinically meaningful side effect of cancer treatment. CIPN is induced by neurotoxic agents, causing severe sensory and/or motor deficits, resulting in disability and poor recovery, reducing patients quality of life and limiting medical therapy. To date, effective treatment options are lacking. Whole-body vibration (WBV) training can attenuate motor and sensory deficits. We are conducting a two-armed, multicentre, assessor-blinded, randomised controlled trial, to investigate the effects of WBV on relevant symptoms of CIPN and determine the training characteristics. METHODS AND ANALYSIS: In this ongoing study, 44 patients who have completed therapy in the past 3 months, with a neurologically confirmed CIPN are assessed before and after a 12-week intervention and follow-up. The intervention group receives WBV twice a week. Exercises are individually tailored according to the initially determined optimal ...
Rapid advances have been made in the diagnosis and treatment of neurological disease over the last two decades. Over that period, major developments have also occurred in other fields of medicine, most notably in the management of cancer. Two-thirds of all cancer patients now survive at 5-years post-diagnosis, with over 28 million cancer survivors worldwide.1 As cancer outcomes improve, there has been increased focus on the long-term quality of life in cancer survivors. Not unexpectedly, neurological complications are a prevalent and potentially disabling long-term side effect of cancer treatment. Chemotherapy-induced peripheral neuropathy (CIPN), in particular, is the dose-limiting toxicity of many chemotherapeutic agents, … ...
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most challenging and complex complications of cancer chemotherapy.
Chemotherapy-induced peripheral neuropathy (CIPN) is the most frequent cause of dose reduction or treatment discontinuation in patients treated for cancer with...
ASCO has released a clinical practice guideline on prevention and treatment of chemotherapy-induced peripheral neuropathy in adult cancer patients, published in the Journal of Clinical Oncology.1. The guidelines resulted from the efforts of an expert panel, with representation from the fields of medical oncology, community oncology, nursing, pain research, genetics, neurology, pharmacology, patient representation, and guideline methodology. Charles Loprinzi, MD, of the Mayo Clinic, Rochester, Minnesota, and Dawn Hershman, MD, of Columbia University Medical Center, New York, were the panel co-chairs.. The overall incidence of the condition is estimated at close to 40% in patients treated with multiple agents, with reported rates varying according to chemotherapy regimens, duration of exposure, and assessment methods. Regimens associated with higher risk are those including platinum drugs, vinca alkaloids, bortezomib (Velcade), and taxanes.. Clinical Question. The clinical question addressed by ...
Multivitamin supplements may reduce incidence of chemotherapy-induced peripheral neuropathy among women undergoing treatment with paclitaxel for breast cancer, according to results of a study led by researchers at Roswell Park Comprehensive Cancer Center.“Our study showed that use of multivitamin supplements, but not specific vitamins, was associated with less neurotoxicity,”
TY - JOUR. T1 - A new approach to prevent the chemotherapy-induced peripheral neuropathy. AU - Kawashiri, Takehiro. PY - 2019/1/1. Y1 - 2019/1/1. UR - http://www.scopus.com/inward/record.url?scp=85064722410&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85064722410&partnerID=8YFLogxK. U2 - 10.1254/fpj.153.200. DO - 10.1254/fpj.153.200. M3 - Comment/debate. C2 - 30971662. AN - SCOPUS:85064722410. VL - 153. JO - Folia Pharmacologica Japonica. JF - Folia Pharmacologica Japonica. SN - 0015-5691. IS - 4. ER - ...
This proposal seeks to examine mechanisms of paclitaxel-induced peripheral neuropathy by emphasizing on epidermal damage and the role of the matrix-degrading en...
Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting side effect of many chemotherapeutic agents including vincristine, paclitaxel, cisplatin, oxaliplatin, bortezomib and ixabepilone. Chemotherapy-induced peripheral neuropathy commonly occurs in greater than 40% of patients. To improve the peripheral neuropathy, the chemotherapy dosing is often either decreased or discontinued potentially affecting tumor responsiveness, prognosis, and survival.. There is an unmet medical need for treatment of cancer patients with chemotherapy induced neuropathic pain (CINP) and the proposed study will investigate the efficacy and safety of multiple dose levels of tetrodotoxin (TTX) versus placebo in moderate to severe neuropathic pain caused by chemotherapy. ...
Condition: Chemotherapy-induced Peripheral Neuropathy Intervention: Sponsors: Carsten Dahl Mørch; Aalborg University Hospital Not yet recruiting...
Dublin, Dec. 05, 2018 (GLOBE NEWSWIRE) -- The Chemotherapy-Induced Peripheral Neuropathy (CIPN) - Market Insights, Epidemiology and Market Forecast...
A recent study evaluated the efficacy of cryotherapy for chemo-induced peripheral neuropathy; study participants wore frozen gloves and socks on the dominant side for 90 minutes, including the entire duration of drug infusion.
The USF College of Nursing is pleased to host Ellen M. Lavoie Smith, PhD, APRN, AOCN®, FAAN, who will present Bedside to Bench to Bedside: Managing Painful Chemotherapy-Induced Peripheral Neuropathy at noon on Tuesday, March 5, in MDN 2005. Dr. Smith is an associate professor and director of the PhD program at the University of Michigan School of Nursing. Her program of research is focused on improving the assessment and treatment of chronic, cancer-related neuropathic pain, with a specialty focus in painful chemotherapy-induced peripheral neuropathy. She has received independent research funding from the National Institutes of Health, the Oncology Nursing Society, the American Cancer Society, Dartmouth, and the University of Michigan. Dr. Smith conducted a cross-sectional study evaluating the clinimetric properties of peripheral neuropathy and neuropathic pain measurement approaches. She also completed an Oncology Nursing Society-funded study focused on utilizing quality improvement ...
The USF College of Nursing is pleased to host Ellen M. Lavoie Smith, PhD, APRN, AOCN®, FAAN, who will present Bedside to Bench to Bedside: Managing Painful Chemotherapy-Induced Peripheral Neuropathy at noon on Tuesday, March 5, in MDN 2005. Dr. Smith is an associate professor and director of the PhD program at the University of Michigan School of Nursing. Her program of research is focused on improving the assessment and treatment of chronic, cancer-related neuropathic pain, with a specialty focus in painful chemotherapy-induced peripheral neuropathy. She has received independent research funding from the National Institutes of Health, the Oncology Nursing Society, the American Cancer Society, Dartmouth, and the University of Michigan. Dr. Smith conducted a cross-sectional study evaluating the clinimetric properties of peripheral neuropathy and neuropathic pain measurement approaches. She also completed an Oncology Nursing Society-funded study focused on utilizing quality improvement ...
The main side effects of vincristine are chemotherapy-induced peripheral neuropathy, hyponatremia, constipation, and hair loss. Chemotherapy-induced peripheral neuropathy can be severe, and may be a reason to reduce or avoid using vincristine. The symptoms of this are progressive and enduring tingling numbness, pain and hypersensitivity to cold, beginning in the hands and feet and sometimes affecting the arms and legs.[9] One of the first symptoms of peripheral neuropathy is foot drop: A person with a family history of foot drop and/or Charcot-Marie-Tooth disease (CMT) should avoid the taking of vincristine.[10]. Accidental injection of vinca alkaloids into the spinal canal (intrathecal administration) is highly dangerous, with a mortality rate approaching 100 percent. The medical literature documents cases of ascending paralysis due to massive encephalopathy and spinal nerve demyelination, accompanied by intractable pain, almost uniformly leading to death. Several patients have survived after ...
Chemotherapy can impact or damage the bodys peripheral nerves. Peripheral nerves carry sensations (or neurological messages) to and from the brain and spine, to control feeling and movement in different parts of the body including arms, legs, hands and feet. They also control the bowel and bladder. Damage to peripheral nerves that is caused by chemotherapy is called
Paclitaxel is an effective chemotherapeutic agent widely used for the treatment of solid tumors. The major dose-limiting toxicity of paclitaxel is peripheral neuropathy. The mechanisms underlying the development and maintenance of paclitaxel-induced peripheral neuropathy are still unclear, and there are no currently established effective treatments. Accumulating evidence in models of neuropathic pain in which peripheral nerves are lesioned has implicated spinal microglia and chemokines in pain hypersensitivity, but little is know about their roles in chemotherapy-induced peripheral neuropathy. In the present study, we investigated the role of CC-chemokine ligand 3 (CCL3) in the spinal cord in the development and maintenance of mechanical allodynia using a rat model of paclitaxel-induced neuropathy. Repeated intravenous administration of paclitaxel induced a marked decrease in paw withdrawal threshold in response to mechanical stimulation (mechanical allodynia). In these rats, the number of microglia in
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G. Peripheral Nerve Disorders: Pathology and Genetics is a definitive, clinically-oriented guide to the pathology of peripheral nerve disorders.. These commonly seen neurological challenges have many causes and accurate diagnosis is often necessary via pathological analysis. New techniques exploiting molecular biological knowledge have opened up new vistas to understanding the pathogenesis of these disorders, and hence, their effective management.. This new title takes a disease-oriented approach to understanding the pathology of these conditions. It combines classical and contemporary techniques to enable practitioners in neurology and neuropathology to better understand the disease processes underlying patients presentations and to formulate appropriate management plans.. Peripheral Nerve Disorders: Pathology and Genetics is a valuable resource for neurologists, neuropathologists, pathologists, neurobiologists and geneticists.. Jean-Michel Vallat, Neurology Laboratory, National Referral ...
DESCRIPTION (provided by applicant): Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side-effect arising in ~400,000 cancer patients yearly and often limits chemotherapy dosage. Pain and other quality of life impairments caused by CIPN are increasing as many forms of cancer become chronic conditions, with an estimated annual cost of ~$2.5 billion dollars (NCI Directors Consensus Workshop, June 2011). It has been assumed that as target-specific therapies were discovered, the off-target effect of peripheral neuropathy would lessen. However, as specific mechanism-based therapies (e.g. proteasome and Jak-2 inhibitors) have been introduced, the incidence of painful, chronic neuropathy has persisted at 30-40% of treated patients. Approaches to limit the impact of CIPN include prevention and symptomatic treatment of neuropathic pain. Preventive strategies are complicated by the risk that protection from CIPN may reduce the primary cancer cell killing effect of a drug. Symptomatic ...
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Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and incapacitating complications of tumor treatment. outcomes the group of studies revealed essential lessons which have up to date subsequent function. Some examples of the include the usage of patient-reported indicator metrics the eradication of traditional-yet unsubstantiated-practice techniques as well as the breakthrough of molecular hereditary predictors of neuropathy. Current inquiry has been guided with the outcomes from these large-scale studies and therefore stands better potential for identifying long lasting solutions because of this treatment-limiting toxicity. = 0.003). The magnitude of the power from duloxetine was humble and were even more prominent with neuropathy due to oxaliplatin in comparison to paclitaxel within a subset evaluation. There is a considerably higher occurrence of CTCAE quality 2 or better exhaustion in the duloxetine arm but in any other case the medicine was well-tolerated. Organic ...
Impaired physical function due to chemotherapy-induced peripheral neuropathy (CIPN) symptoms may lead to diminished quality of life. However, even with the knowledge of the effects of CIPN on physical function, clinicians infrequently assess and manage CIPN. Interventions that prioritize the early identification of CIPN to provide prompt treatment may reduce the impact of CIPN on physical function. The purpose of this paper is to compare self-reported physical function in individuals receiving neurotoxic chemotherapy between Electronic Symptom Assessment-Cancer (ESRA-C) intervention group (e.g., opportunity for symptom screening, self-care recommendations, communication coaching, and symptom tracking) and control group participants (i.e., electronic assessment alone). Secondary outcomes include pain intensity, sensory/motor CIPN, depression, fatigue, and insomnia. The data used in this paper are a subset of a randomized controlled trial that examined the impact of the ESRA-C intervention on symptom
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting and disabling side effect of taxane anticancer agents. We prospectively evaluated the efficacy of cryotherapy for CIPN prevention. Methods: Breast cancer patients treated weekly with paclitaxel (80 mg/m2 for one hour) wore frozen gloves and socks on the dominant side for 90 minutes, including the entire duration of drug infusion. Symptoms on the treated sides were compared with those on the untreated (nondominant) sides. The primary end point was CIPN incidence assessed by changes in tactile sensitivity from pretreatment baseline in a monofilament test at a cumulative dose of 960 mg/m2. We also assessed thermosensory deficits, subjective symptoms (Patient Neuropathy Questionnaire [PNQ]), manipulative dexterity, and the time to events and hazard ratio by PNQ. All statistical tests were two-sided. Results: Among the 40 patients, four did not reach the cumulative dose (due to the occurrence of pneumonia, severe ...
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and clinically relevant side effect of chemotherapy. Approximately 50% of all leukemia, lymphoma, colorectal- and breast cancer patients are affected. CIPN is induced by neurotoxic chemotherapeutic agents and can manifest with sensory and/or motor deficits. It is associated with significant disability and poor recovery. Common symptoms include pain, altered sensation, reduced or absent reflexes, muscle weakness, reduced balance control and insecure gait. These symptoms not only affect activities of daily living, subsequently reducing patients quality of life, they have far more become a decisive limiting factor for medical therapy, causing treatment delays, dose reductions, or even discontinuation of therapy, which can affect the outcome and compromise survival. To date, CIPN cannot be prevented and its occurrence presents a diagnostic dilemma since approved and effective treatment options are lacking. Promising results ...
PEA is a fatty acid amide made in the body. It performs a variety of biological functions related to chronic and neuropathic pain and inflammation. These include diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, neuropathic pain, osteoarthritis, low back pain, chronic pelvic pain, post-herpetic neuralgia and neuropathic pain in stroke and MS. To date 20 clinical trials and nearly 2000 patients have been treated with PEA with positive results. Worldwide more than 800,000 patients have been treated with PEA. There has been no reported side-effects or medication interactions.. DIRECTIONS. Take 1 capsule twice a day, then 2 capsules twice a day after a few weeks. Can take up to 4 capsules twice day. Does not need to be taken with food and there is very little interaction with other medications. PEA capsules may be taken with a multi-B vitamin which is beneficial for nerve health, or Turmeric to decrease inflammation. Magnesium Glycinate 200mg capsules are also ...
Another feature review covers the difficult-to-manage syndrome of chemotherapy-induced peripheral neuropathy (CIPN), which is poorly understood physiologically and is clinically manifested in variable fashion in terms of onset and chronicity. Drs Trivedi, Hershman, and Crew provide a very helpful overview on the physiology and clinical spectrum of CIPN, with strategies on surveillance and grading-an approach that should become standard practice. The difficulty in managing CIPN is highlighted, with a review of approaches with demonstrated benefit, but an acknowledgment that responses are variable and far from adequate, highlighting the need for more research and awareness of this common treatment side effect ...
In this online course, the Canadian Physiotherapy Association is assessing Chemotherapy-Induced Peripheral Neuropathy in the pediatric population.
POSTDOCTORAL POSITION IN NEUROPHYSIOLOGY OF CHRONIC PAIN. Team: Fundamental and clinical pharmacology of Pain (http://www. https://neurodol.uca.fr). Location: Laboratoire de Pharmacologie Fondamentale et Clinique de la Douleur, Neuro-Dol (UMR Inserm 1107), Clermont-Ferrand, France. Start date: September 2021. We seek to hire a highly motivated postdoctoral researcher to 1/ characterize HCN activity in brain areas involved in pain processing and to 2/ investigate the efficacy of a new pharmacological strategy of HCN modulation to reduce chronic pain and comorbidities (anxiety and depression) in a mice model of chemotherapy-induced peripheral neuropathy, using a combination of approaches including brain slice electrophysiology, cell imaging, stereotactic brain injections and genetically-modified mice.. The candidate should hold a PhD in Neurobiology or Neuropharmacology and have a solid background in cellular electrophysiology (patch-clamp in brain slices). The candidate should also show strong ...
Duvigneau, S.; Kettner, A.; Carius, L.; Griehl, C.; Findeisen, R.; Kienle, A.: Fast, inexpensive, and reliable HPLC method to determine monomer fractions in poly(3-hydroxybutyrate-co-3-hydroxyvalerate). Applied Microbiology and Biotechnology 105, pp. 4743 - 4749 (2021 ...
Women who take multivitamin supplements before their breast cancer diagnosis and during chemotherapy appear to be less likely to develop the debilitating, often long-lasting symptoms of chemotherapy-induced peripheral neuropathy. Image © NIKITA TV / Shutterstock.com. ...
Toby C. Campbell, MD is a member of the University of Wisconsin Carbone Cancer Center as an associate professor of medicine within the hematology-oncology section of the UW School of Medicine and Public Health as well as chief of the Palliative Care program and program director of the Palliative Care fellowship training program. Dr. Campbell received his medical degree from the University of Virginia and completed his internal medicine residency at the University of Wisconsin Hospital and Clinics. He recently completed fellowships in medical oncology and palliative medicine at Northwestern University.. Dr. Campbells clinical practice interests are in Lung Cancer, symptom management, communication and Palliative Care. His clinical research interests are in lung cancer therapeutics, chemotherapy-induced peripheral neuropathy, symptom management, and interdisciplinary medical teams. He is a member of the American Society of Clinical Oncology, American Association of Hospice and Palliative Medicine ...
Methods 17 gastrointestinal cancer survivors (14 colorectal and 3 gastric cancers), who had been treated with oxaliplatin-based chemotherapies, were recruited. Low-level laser stimulation (50 mW) bilaterally at PC6, PC7, PC8, P9, LU11, SP6, KI3, BL60, KI1, and KI2 was administered for 20 min/point for 12 sessions over 4 weeks. The pain quality assessment scale (PQAS), chemotherapy-induced neurotoxicity questionnaire (CINQ), oxaliplatin-specific neurotoxicity scale (OSNS), quantitative touch-detection threshold (using von Frey filaments), and cold-triggered pain withdrawal latency (using the cold-water immersion test) were measured before and after completion of the 12 treatment sessions. ...
We aimed at validating the role of genetic variants identified by a recent genome-wide association study (GWAS) as determinants of chronic oxaliplatin-induced peripheral neurotoxicity (OXAIPN). Eight polymorphisms (rs10486003, rs2338, rs843748, rs797519, rs4936453, rs12023000, rs17140129, and rs6924 …
Oxaliplatin, the third-generation platinum compound, has evolved as one of the most important therapeutic agents in colorectal cancer chemotherapy. The main limiting factor in oxaliplatin treatment is painful neuropathy that is difficult to treat. This side effect has been studied for several years, but its full mechanism is still inconclusive, and effective treatment does not exist. Data suggest that oxaliplatins initial neurotoxic effect is peripheral and oxidative stress-dependent. A spinal target is also suggested in its mechanism of action. The flavonoids rutin and quercetin have been described as cell-protecting agents because of their antioxidant, antinociceptive, and anti-inflammatory actions. We proposed a preventive effect of these agents on oxaliplatin-induced painful peripheral neuropathy based on their antioxidant properties. Oxaliplatin (1 mg/kg, i.v.) was injected in male Swiss mice, twice a week (total of nine injections). The development of sensory alterations, such as thermal and
StimRouter can change the way healthcare professionals treat chronic peripheral pain by targeting and neuromodulating the affected nerve.
Rieger conducted her research in zebrafish exposed to paclitaxel, a chemotherapeutic agent used for ovarian, breast, lung, pancreatic and other cancers. Paclitaxel-induced peripheral neuropathy affects the majority of treated patients; however, those who are most severely affected (about 30 percent) have to terminate chemotherapy or reduce the dose because of this condition, which can impact cancer survival.. Rieger used zebrafish larvae to model peripheral neuropathy because the embryos develop rapidly and because the larval fish are translucent, making them ideal for studying the progression of nerve degeneration in live animals.. Riegers research showed that paclitaxel induces the degeneration of sensory nerve endings by damaging the outer layer of the skin, or epidermis. The epidermis is innervated by free sensory nerve endings that establish direct contact with skin cells. Her research showed that degeneration is caused by perturbations in the epidermis due to an increase in ...
Peripheral neuropathies are common and affect almost eight percent of the population over age 55. New diagnostic and management options make rational therapies for PN increasingly possible. The high cost of certain diagnostic tests and therapies, along with the complexities involved in choosing which tests and treatments to initiate, complicate the management of patients with PN. Faculty will provide an update on diagnosis and management of diabetic neuropathies, immune axonal neuropathies, and neuropathies associated with hematologic disorders, including ATTR amyloidosis. This program complements Peripheral Neuropathy I: Anatomical Basis and Acquired Demyelinating Neuropathies and Peripheral Neuropathy III: Genetic Neuropathies: Molecular Diagnosis and Treatment Perspectives, but covers independent topics ...
TY - JOUR. T1 - Medial plantar sensory response. Sensitive indicator of peripheral nerve dysfunction in patients with diabetes mellitus. AU - Reeves, Michael L.. AU - Seigler, Deborah E.. AU - Ayyar, D. Ram. AU - Skyler, Jay S.. N1 - Funding Information: From the Departments of Medicine, Pediatrics, Neurology and Diabetes-Endocrinology Unit, University of Miami School of Medicine, Miami, Florida. This work was supported under contracts with the Department of Health and Rehabilitative Services of the State of Florida for the University of Miami/Southeastern Florida Regional Diabetes Program (Health Program Off ice) and for the Regional Diabetes Program for Children and Youth (Childrens Medical Services Prooram). and bv grants from Novo Laboratories,-Inc.:. Wilton, Connecticut, and the Diabetes Research Institute Foundation, Miami, Florida. Requests for reprints should be addressed to Dr. MichaelL . Reeves, University of Miami, Diabetes-Endocrinology Unit (D-l), P.O. pox 016960, Miami, Florida ...
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Integrative Approaches for Cancer-Related Neuropathic Pain by Ilyse Streim, Oncology Massage Therapist Neuropathic pain is a chronic, often debilitating problem that affects a significant number of cancer patients. Peripheral neuropathy is defined as any injury, inflammation, or degeneration of the peripheral nerve fibers. Both chemotherapy and radiation can cause peripheral neuropathy, although chemotherapy-induced peripheral neuropathy…
Peripheral Neuropathy. The most common causes of peripheral neuropathies are diabetes mellitus, vitamin deficiency, alcoholism associated with poor.. There are three main kinds of peripheral nerves - sensory nerves that control. The disease process can be diabetic neuropathy, which is caused by diabetes. Section 9.08 focuses on neuropathy that is in conjunction with diabetes mellitus.. CAUSES OF DIABETIC PERIPHERAL NEUROPATHY ] The REAL cause of Diabetes (and the solution),Causes Of Diabetic Peripheral Neuropathy As was stated earlier in the article diabetes happens a whole lot these days. If you are currently living with it anyone are concerned that you could develop it keep with such simple and tricks in.. May 13, 2016. Symptoms of diabetic peripheral neuropathy (pain, paresthesias, among adults age 18 or older with type 1 or type 2 diabetes mellitus?. Peripheral neuropathy has many forms and causes. Some of the causes are still unknown. The most common cause is diabetes. Other common ...
Diabetic Peripheral Neuropathy-Pipeline Review, H1 2015. Summary. Global Markets Directs, Diabetic Peripheral Neuropathy-Pipeline Review, H1 2015, provides an overview of the Diabetic Peripheral Neuropathys therapeutic pipeline.. This report provides comprehensive information on the therapeutic development for Diabetic Peripheral Neuropathy, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Diabetic Peripheral Neuropathy and special features on late-stage and discontinued projects.. Global Markets Directs report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Directs proprietary databases, ...
Charcot-Marie-Tooth 2B peripheral sensory neuropathy (CMT2B) is a debilitating autosomal dominant hereditary sensory neuropathy. Patients with this disease lose pain sensation and frequently need amputation. Axonal dysfunction and degeneration of peripheral sensory neurons is a major clinical manifestation of CMT2B. However, the cellular and molecular pathogenic mechanisms remain undefined. CMT2B is caused by missense point mutations (L129F, K157N, N161T/I, V162M) in Rab7 GTPase. Strong evidence suggests that the Rab7 mutation(s) enhances the cellular levels of activated Rab7 proteins, thus resulting in increased lysosomal activity and autophagy. As a consequence, trafficking and signaling of neurotrophic factors such as nerve growth factor (NGF) in the long axons of peripheral sensory neurons are particularly vulnerable to premature degradation. A
Treatment for Diabetic Peripheral Neuropathy in Nulife Hospital, Mumbai. Find Doctors Near You, Book Appointment, Consult Online, View Doctor Fees, Address, Phone Numbers and Reviews. Doctors for Diabetic Peripheral Neuropathy in Nulife Hospital, Mumbai | Lybrate
Peripheral neuropathy is a term used to describe damage to nerves of the peripheral nervous system which leads to symptoms such as pain, numbness, tingling, burning, and weakness most commonly affecting the hands and feet. Peripheral neuropathy can be caused by a variety of precipitating factors including trauma, infection, diabetes, alcohol abuse, and cancer chemotherapy.. The incidence of peripheral neuropathy is not known with any degree of certainty. It has been estimated that approximately 2 to 3 million Americans have some form of peripheral neuropathy. The prevalence of peripheral neuropathy worldwide has been estimated to range from 2% to 8% of the population. Peripheral neuropathy affects both genders at all ages but symptoms are unique to each individual in terms of frequency, quality, and severity of pain. Idiopathic peripheral neuropathy typically affects adults over the age of 50. Peripheral neuropathy can significantly impact an individuals quality of life and daily activities by ...
Peripheral neuropathy is a term used to describe damage to nerves of the peripheral nervous system which leads to symptoms such as pain, numbness, tingling, burning, and weakness most commonly affecting the hands and feet. Peripheral neuropathy can be caused by a variety of precipitating factors including trauma, infection, diabetes, alcohol abuse, and cancer chemotherapy.. The incidence of peripheral neuropathy is not known with any degree of certainty. It has been estimated that approximately 2 to 3 million Americans have some form of peripheral neuropathy. The prevalence of peripheral neuropathy worldwide has been estimated to range from 2% to 8% of the population. Peripheral neuropathy affects both genders at all ages but symptoms are unique to each individual in terms of frequency, quality, and severity of pain. Idiopathic peripheral neuropathy typically affects adults over the age of 50. Peripheral neuropathy can significantly impact an individuals quality of life and daily activities by ...
TY - JOUR. T1 - Simplification of the research diagnosis of HIV-associated sensory neuropathy. AU - Evans, Scott R.. AU - Clifford, David B.. AU - Kitch, Douglas W.. AU - Goodkin, Karl. AU - Schifitto, Giovanni. AU - McArthur, Justin Charles. AU - Simpson, David M.. PY - 2008/11. Y1 - 2008/11. N2 - Peripheral neuropathy (PN) is the most common neurological complication of HIV infection, affecting over one third of patients. The research diagnosis of PN is complicated by the need for expensive, time-consuming, and noxious diagnostic tests. We investigated whether nerve conduction studies (NSC) and quantitative sensory tests (QST) provide added value for the diagnosis of PN for research purposes or whether the easily obtainable clinical measures (sensory and motor symptoms, sensitivity to pain and vibration, tendon reflexes, motor function) are sufficient.. AB - Peripheral neuropathy (PN) is the most common neurological complication of HIV infection, affecting over one third of patients. The ...
May 4, 2016. Information on early-onset peripheral neuropathy, a disease VA. evidence to suggest that neuropathy of acute or subacute onset may be.. Clinical Professor, Department of Medical Oncology, Prince of Wales Hospital, Australia and Prince of Wales Clinical School, University of New South Wales.. Small Fiber Sensory Peripheral Neuropathy View FAQs and learn more from Cleveland Clinic about diagnosing small fiber sensory neuropathy with skin biopsies. Find additional resources and staff. Feb 27, 2015. In the last few years weve seen. Mar 19, 2014. Peripheral myelin protein 22 (PMP22)Charcot-Marie-Tooth disease type 1A. Neuropathy type III) is a hereditary neuropathy with early onset and severe presentation. Typically, CIDP shows a subacute or fluctuating course, multi- focal. Although not being a typical transient nerve palsy, sensorineural.. Disorders. All Disorders. NINDS Binswangers Disease Information Page; NINDS Brachial Plexus Injuries Information Page; NINDS Brown-Sequard ...
Obtaining a differential diagnosis is critical to stemming the progression of the disease and beginning the healing process and regeneration of the damaged nerves, if possible. A range of both positive and negative outcomes have been noted in a wide range of medical conditions when using the Tens machine. My feet hurt all the time, I had trouble standing on them for any length of time, going to grade 3 peripheral neuropathy youtube grocery store and walking on concrete floors drove me to tears, and when my neurologist would poke pins in my feet and lower legs, I could not tell they were pushing the pin in there. She required assistance to stand and walked with bilateral support, a wide-based gait, and slow shuffling steps. The length of abnormal enhancement did not correlate with the duration of visual loss prior to the MRI.
TY - JOUR. T1 - Weighted needle pinprick sensory thresholds: a simple test of sensory function in diabetic peripheral neuropathy. AU - Chan, A W AU - MacFarlane, I A AU - Bowsher, David. AU - Campbell, Jacqueline Ann. PY - 1992/1/1. Y1 - 1992/1/1. N2 - A simple device is described, consisting of 12 weighted 23 gauge disposable needles (0.2 to 5.2 g), for testing sensation in busy diabetic clinics. The pinprick sensory threshold (PPT) is the lightest weighted needle which consistently elicits a sharp sensation. The subjects were 48 healthy controls (hospital staff), 44 diabetic patients without neuropathic symptoms, and 35 diabetic patients with chronic painful neuropathy. In the controls, the mean PPT from the right hand and foot obtained on two test occasions a week apart did not differ significantly. In diabetic patients without symptomatic neuropathy, the mean PPT in the right hand and right foot were significantly higher than in the controls. The diabetic patients with painful neuropathy had ...
TY - JOUR. T1 - Postural sway in diabetic peripheral neuropathy among Indian elderly. AU - Dixit, Snehil. AU - Maiya, Arun. AU - Shasthry, B. A.. AU - Kumaran, D. Senthil. AU - Guddattu, Vasudeva. PY - 2015/12/1. Y1 - 2015/12/1. N2 - Background & objectives: Diabetic peripheral neuropathy (DPN) is a major complication of type 2 diabetes and have long term complications on the postural control of the affected population. The objectives of this study were to evaluate postural stability in patients with DPN and to examine correlation of Michigan Neuropathy Screening Instrument (MNSI) with duration of diabetes, age and postural stability measures. Methods: Participants were included if they had clinical neuropathy which was defined by MNSI. Sixty one patients gave their consent to participate in the study and were evaluated on posturography for postural stability measures in four conditions. Repeated measures of analysis of variance (RANOVA) was used to analyze the changes in postural stability ...
TY - JOUR. T1 - Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep. AU - Gore, Mugdha. AU - Brandenburg, Nancy A.. AU - Dukes, Ellen. AU - Hoffman, Deborah L.. AU - Tai, Kei Sing. AU - Stacey, Brett. PY - 2005/10/1. Y1 - 2005/10/1. N2 - Our goal was to evaluate pain severity, pain-related interference with function, sleep impairment, symptom levels of anxiety and depression, and quality of life among patients with painful diabetic peripheral neuropathy (DPN). Participants in a burden of illness survey (n = 255) completed the modified Brief Pain Inventory-DPN (BPI-DPN), MOS Sleep Scale, Hospital Anxiety and Depression Scale (HADS), Short Form Health Survey-12v2 (SF-12v2), and the EuroQoL (EQ-5D). Patients were 61 ± 12.8 years old (51.4% female), had diabetes for 12 ± 10.3 years and painful DPN for 6.4 ± 6.4 years. Average and Worst Pain scores (BPI-DPN, 0-10 scales) were 5.0 ± 2.5 and 5.6 ± 2.8. Pain ...
We conducted a GWAS of paclitaxel-induced cytotoxicity in LCLs and showed significant enrichment of the top cytotoxicity-associated SNPs in a clinical GWAS of paclitaxel-induced sensory peripheral neuropathy in patients with breast cancer. This robust enrichment shows that susceptibilities to increased cytotoxicity in LCLs and sensory peripheral neuropathy in patients with breast cancer likely have some genetic mechanisms in common and supports the role of LCLs as a preclinical model for paclitaxel toxicity studies. Furthermore, the top SNPs that overlap between the 2 studies were enriched for eQTLs. This eQTL enrichment indicates that SNPs associated with paclitaxel-induced toxicity phenotypes may be functioning through gene regulatory mechanisms. Interestingly, neither GWAS alone was enriched for eQTLs. Thus, our integration method may be reducing noise and revealing important functional SNPs. An enrichment of eQTLs has previously been shown in SNPs associated with 6 other chemotherapeutic ...
Polyneuropathy is a common peripheral nerve disorder that often has a well known cause such as diabetes, chronic renal disease, alcohol abuse, vitamin deficiency, hypothyroidism, or use of toxic medication. Elderly people are more often affected, but the differentiation from signs of normal ageing can be difficult. It is important ... read more to diagnose a polyneuropathy and establish the cause at an early stage, because treatment can ameliorate symptoms and prevent progression. Because of the ageing population, the number of people affected by a polyneuropathy can be expected to increase. This thesis deals with questions regarding the efficient work-up and treatment strategies for chronic axonal polyneuropathy. A succinct description of the main study results is as follows. In about 25% of healthy elderly people older than 60 years the vibration sense at the big toes or ankles and the ankle jerks can be absent, and this should be taken into account when developing a clinical diagnostic ...
Peripheral neuropathy may be either inherited or acquired. Causes of acquired peripheral neuropathy include physical injury (trauma) to a nerve, tumors, toxins, autoimmune responses, nutritional deficiencies, alcoholism, and vascular and metabolic disorders. Acquired peripheral neuropathies are grouped into three broad categories: those caused by systemic disease, those caused by trauma from external agents, and those caused by infections or autoimmune disorders affecting nerve tissue. One example of an acquired peripheral neuropathy is trigeminal neuralgia (also known as tic douloureux), in which damage to the trigeminal nerve (the large nerve of the head and face) causes episodic attacks of excruciating, lightning-like pain on one side of the face. In some cases, the cause is an earlier viral infection, pressure on the nerve from a tumor or swollen blood vessel, or, infrequently, multiple sclerosis. In many cases, however, a specific cause cannot be identified. Doctors usually refer to ...
TY - JOUR. T1 - Sural nerve biopsy in peripheral neuropathies. T2 - 30-year experience from a single center. AU - Luigetti, Marco. AU - Di Paolantonio, Andrea. AU - Bisogni, Giulia. AU - Romano, Angela. AU - Conte, Amelia. AU - Barbato, Francesco. AU - Del Grande, Alessandra. AU - Madia, Francesca. AU - Rossini, Paolo Maria. AU - Lauretti, Liverana. AU - Sabatelli, Mario. PY - 2019/10/24. Y1 - 2019/10/24. N2 - INTRODUCTION: Nerve biopsy has been widely used to investigate patients with peripheral neuropathy, and in many centers, it is still a useful diagnostic tool in this setting. In this study, we reviewed the histopathological spectrum of the nerve biopsies performed in our center in a 30-year period and we analyzed their relevance in the clinical setting.MATERIALS AND METHODS: Retrospective analysis of the retrieved data was done for cases of nerve biopsies performed in our institute between 1988 and 2018. Surgical technique and histopathological analysis were done accordingly to standard ...
Professor Hugh Willison is a tenured staff member at the University of Glasgow College of Medicine, Veterinary and Life Science in the Institute of infection Immunity and Inflammation, and also holds an Honorary Clinical Consultant Neurologist contract with the South Glasgow University Hospitals NHS Trust.. He has a specialist interest in peripheral nerve disorders and researches this area at the clinical and laboratory level. In particular, he combines his clinical and research activity on autoimmune diseases including Guillain Barre syndrome and chronic inflammatory neuropathies. He also directs a clinical diagnostic laboratory that conducts immunological tests of relevance to peripheral nerve disorders, including anti-glycolipid, anti-MAG and anti-neuronal antibodies. He received his undergraduate training at the Middlesex Hospital and clinical training in Neurology at the Royal Free Hospital and National Hospital, London.. He received his PhD training in the Myelin and Brain Development ...
TY - JOUR. T1 - Optochiasmatic and peripheral neuropathy due to ethambutol overtreatment. AU - Geyer, Howard L.. AU - Herskovitz, Steven. AU - Slamovits, Thomas L.. AU - Schaumburg, Herbert H.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Ethambutol is known to cause optic neuropathy and, more rarely, axonal polyneuropathy. We characterize the clinical, neurophysiological, and neuroimaging findings in a 72-year-old man who developed visual loss and paresthesias after 11 weeks of exposure to a supratherapeutic dose of ethambutol. This case demonstrates the selective vulnerability of the anterior visual pathways and peripheral nerves to ethambutol toxicity.. AB - Ethambutol is known to cause optic neuropathy and, more rarely, axonal polyneuropathy. We characterize the clinical, neurophysiological, and neuroimaging findings in a 72-year-old man who developed visual loss and paresthesias after 11 weeks of exposure to a supratherapeutic dose of ethambutol. This case demonstrates the selective vulnerability of ...
The Epidermal Nerve Fiber Density (ENFD) test is an objective method of documenting small fiber peripheral neuropathy by quantifying the terminal branches of peripheral nerves within the epidermis. The test is highly specific and sufficiently sensitive with 97% of accuracy rate. The test is recommended to perform when patients experience the following symptoms: pain and abnormal sensation (burning, prickling, shooting), as well as numbness, tightness, coldness in foot/ankle areas.. The common causes of small fiber peripheral neuropathy are: diabetes, types I & II; HIV; vibratory trauma; amyloidosis / monoclonal gammopathy; alcohol abuse; pharmacologic toxins (metronidazole); solvent exposure, and idiopathic neuropathy, when the cause cant be determined, once thought to represent as much as half of all cases.. The ENFD test can also be used to predict the small nerve fiber peripheral neuropathy.. A small 3×3 mm skin biopsy is used for providing diagnostic information on small nerve fibers. The ...
Most common acute motor polyneuropathy, probably due to post-infectious etiology. mycoplasma and campylobacter infections as well as lymphoma have been associated.. Classically, bilateral ascending weakness, may go all the way to the face. Often heralded by paresthesias.. (rarely, there is a descending form Miller Fisher Variant, ataxia, areflexia, & opthalmoplegia). Can develop acutely over days or subacutely over weeks.. motor,,than sensory, almost invariably have decreased reflexes,. If you intubate, DO NOT USE SUX. Consider autonomic dystability.. Get PFTS or ABG. Extensors of neck are quick/dirty test of impending failure. CSF: Albumin-cytologic disassociation: prot,400, WBC,10. In diff, tick paralysis. Rx:. Plasmapheresis. and/or IVIG 0.4 g/kg/day x 2 weeks. (Steroids are safe to give, but probably have no benefit as treatment). ICU Care. occupational and physical therapy. DVT prophylaxis. Splinting to prevent Achilles contractures. Eye Care. Chest PT. Pts are prone to dysrhythmias so ecg ...
Learn about the causes, symptoms, diagnosis & treatment of Peripheral Nerve Disorders from the Home Version of the Merck Manuals.
Learn about the causes, symptoms, diagnosis & treatment of Peripheral Nerve Disorders from the Home Version of the Merck Manuals.
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Read chapter 561 of Rudolphs Pediatrics, 23e online now, exclusively on AccessPediatrics. AccessPediatrics is a subscription-based resource from McGraw Hill that features trusted medical content from the best minds in medicine.
Global Markets Directs, Diabetic Peripheral Neuropathy - Pipeline Review, H1 2020, provides an overview of the Diabetic Peripheral Neuropathy
Peripheral neuropathy includes a wide range of diseases affecting millions around the world, and many of these diseases have unknown etiology. Peripheral neuropathy in diabetes represents a large proportion of peripheral neuropathies. Nerve damage can also be caused by trauma. Peripheral neuropathies are a significant clinical problem and efficient treatments are largely lacking. In the case of a transected nerve, different methods have been used to repair or reconstruct the nerve, including the use of nerve conduits, but functional recovery is usually poor.. Autophagy, a cellular mechanism that recycles damaged proteins, is impaired in the brain in many neurodegenerative diseases affecting animals and humans. No research, however, has investigated the presence of autophagy in the human peripheral nervous system. In this study, I present the first structural evidence of autophagy in human peripheral nerves. I also show that the density of autophagy structures is higher in peripheral nerves of ...
Small fiber and autonomic neuropathies are common but often unrecognized conditions that affect the peripheral, somatic, and autonomic nervous systems. Through the presentation of didactic material and cases of varying complexity, faculty will facilitate a discussion of the pathophysiology, differential diagnosis, diagnostic evaluation, and therapy of these conditions. Part I will focus more heavily on conditions that impact the autonomic nervous system; Part II will focus more heavily on conditions that impact the somatic or sensory nervous system. Both parts will discuss conditions that may impact the sensory and autonomic small fibers simultaneously. This program complements Small Fiber Neuropathies: Sensory, Autonomic, and Both II: Focus on Sensory Nervous System, but covers independent topics ...
Jinmaitong (JMT), a compound prescription of traditional Chinese medicine, has long been used as a therapy for diabetic peripheral neuropathy (DPN). However, the neuroprotective mechanisms of JMT and its effect on gut microbiota remained unknown. Here, we examined the effects of JMT on behavior, pathomorphology and gut microbiota in streptozotocin (STZ)-induced DPN rats. Compared to distilled water administration, JMT reversed decreases in mechanical withdraw threshold and intraepidermal nerve fiber density, improved neurological morphology of sciatic nerves, increased serum neuregulin 1 (NRG1) level and contactin-associated protein (Caspr)-positive paranodes, and decreased amyloid precursor protein (APP) accumulation in DPN rats. More importantly, JMT enriched nine species of the gut microbiota of DPN rats, helping to prevent dysbiosis. Among these species, p_Actinobacteria, p_Proteobacteria and c_Actinobacteria were negatively correlated with DPN phenotypes and positively correlated with serum
TY - JOUR. T1 - Foot Kinetic and Kinematic Profile in Type 2 Diabetes Mellitus with Peripheral Neuropathy A Hospital-Based Study from South India. AU - Hazari, Animesh. AU - Maiya, Arun G.. AU - Shivashankara, K. N.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - BACKGROUND: A kinetic change in the foot such as altered plantar pressure is the most common etiological risk factor for foot ulcers in people with diabetes mellitus. Kinematic alterations in joint angle and spatiotemporal parameters of gait have also been frequently observed in participants with diabetic peripheral neuropathy (DPN). Diabetic peripheral neuropathy leads to various microvascular and macrovascular complications of the foot in type 2 diabetes mellitus. There is a gap in the literature for biomechanical evaluation and assessment of type 2 diabetes mellitus with DPN in the Indian population. We sought to assess and determine the biomechanical changes, including kinetics and kinematics, of the foot in DPN. METHODS: This cross-sectional ...
Diabetic Peripheral Neuropathy (DPN) is the most common complication of diabetes, and often presents as a distal, symmetric, sensorimotor neuropathy. In the United States, 26.8 million people are affected by diabetes; by the year 2030, that number is predicted to increase to approximately 35.9 million people.. In the U.S. alone, the annual total direct medical and treatment costs of diabetes were an estimated $44 billion in 1997, representing 5.8 percent of total personal healthcare expenditures during that year. When it comes to diabetic peripheral neuropathy and its complications, management is resource intensive and long-term, accounting for a large proportion of this total expenditure. In 2001, the total annual cost of diabetic peripheral neuropathy and its complications in the U.S. was estimated to be between $4.6 and $13.7 billion. Up to 27 percent of the direct medical cost of diabetes may be attributed to diabetic peripheral neuropathy.. More than half of patients who have type 1 or 2 ...
Diabetic peripheral neuropathy doesnt emerge overnight. Instead, it usually develops slowly and worsens over time. Some patients have this condition long before they are diagnosed with diabetes. Having diabetes for several years may increase the likelihood of having diabetic neuropathy.. The loss of sensation and other problems associated with nerve damage make a patient prone to developing skin ulcers (open sores) that can become infected and may not heal. This serious complication of diabetes can lead to loss of a foot, a leg, or even a life.. Causes ...
TY - JOUR. T1 - Neuropathic symptoms and their risk factors in medical oncology outpatients with colorectal vs. breast, lung, or prostate cancer. T2 - Results from a prospective multicenter study. AU - Lewis, Mark A.. AU - Zhao, Fengmin. AU - Jones, Desiree. AU - Loprinzi, Charles L.. AU - Brell, Joanna. AU - Weiss, Matthias. AU - Fisch, Michael J.. PY - 2015/6/1. Y1 - 2015/6/1. N2 - Context Few studies have examined the prevalence and severity of treatment-induced neuropathic symptoms in patients across different cancer types. Objectives This study aimed to report the prevalence of numbness/tingling (N/T) and neuropathic pain in patients with colorectal cancer (CRC) vs. other cancers, describe the prevalence of moderate-to-severe N/T by specific clinical variables, and examine factors associated with the presence of these symptoms. Methods A total of 3106 outpatients with colorectal (n = 718), breast (n = 1544), lung (n = 524), or prostate (n = 320) cancer were enrolled at any point in their ...
Information for behavioral health providers in primary care diabetic neuropathies: the nerve damage of diabetes what are diabetic neuropathies?. Nerve damage from diabetes is called diabetic neuropathy (new-rop-uh-thee). about half of all people with diabetes have some form of nerve damage.. Diabetic neuropathies: the nerve damage of diabetes. national institute of diabetes and digestive and kidney diseases. http://diabetes.niddk.nih.gov/dm/pubs.. Reviews the causes and symptoms of diabetic neuropathy and reviews the different types of neuropathies: peripheral, autonomic, proximal, and focal neuropathies.. Peripheral neuropathy. this type of neuropathy is the most common type affecting people with diabetes and can be felt as pain, tingling, burning, prickling, numbness and complete loss of feeling in the extremities. this is nerve damage in the arms and legs.. What is diabetic neuropathy? diabetic neuropathy is a nerve disorder caused by diabetes. symptoms of neuropathy include numbness and ...
The Food and Drug Administration (FDA) has granted NYX-2925 (Aptinyx) Fast Track designation for the potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPN).
Stop the Pain of Diabetic Peripheral Neuropathy is your information source on how to regenerate damaged nerves and restore quality to life.
Of all of the complications that can come with a diabetes diagnosis, diabetic peripheral neuropathy is arguably one of the most challenging. This condition
PubMed journal article: Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial. Download Prime PubMed App to iPhone, iPad, or Android
Zhao T, Zhao H. Acupuncture for symptomatic treatment of diabetic peripheral neuropathy. Cochrane Database of Systematic Reviews 2015, Issue 6. Art. No.: CD006280. DOI: 10.1002/14651858.CD006280. ...
Those at best possible threat for peripheral neuropathy are those over 40 who are diabetic or pre-diabetic and own poorly managed blood sugar ranges. Whilst you smoke or over win pleasure in alcohol, own an autoimmune disease, undergo chemotherapy, own liver or kidney disease, weight loss program deficiencies or mechanical nerve harm (similar to carpal tunnel syndrome) you would possibly per chance per chance per chance additionally furthermore be at threat.. Furthermore, there are a range of medicines which is in a net site to if truth be told motive peripheral neuropathy as a aspect enact. While all of those are things to put an demand on, even whenever you occur to are no longer diabetic, win no medications, and the checklist above does no longer relate to you, you aloof own a likelihood of presenting in some unspecified time in the future in lifestyles with peripheral neuropathy. A whopping 30% of cases dont own any identifiable root motive.. There are over 100 forms of peripheral ...
Hypotension & Severe Peripheral Motor Neuropathy Symptom Checker: Possible causes include Diabetic Autonomic Neuropathy & Autonomic Neuropathy & Guillain-Barré Syndrome. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
What Is Peripheral Neuropathy? What is peripheral neuropathy. It is a problem or distortion affecting nerves, which can cause the sensation impairment, different types of problems in the movement; it can also destroy the gland or organ due to the bad functioning of the nerves. The problem and the damaged part can be recognized by … Continue reading. ...
This syndrome occurs when a rib or a fibrous band of neuropathy b12 deficiency levels compresses the brachial plexus. In the patients with peripheral neuropathy, the changes were distally predominant, affected mainly sensory fibres, and were consistent with an axonal type of neuropathy. In cases of severe or prolonged peripheral neuropathy, you may experience injuries or infections in your extremities. Phase III placebo-controlled trial of capsaicin cream in the management of surgical neuropathic pain in cancer patients. A diagnostic point that may be helpful in the differentiation from a simple entrapment neuropathy of the ulnar nerve at the elbow is that in HD, the enlargement may extend for a greater distance up the arm or may be maximal some distance proximal to the elbow.
Get information, facts, and pictures about Peripheral Neuropathy at Encyclopedia.com. Make research projects and school reports about Peripheral Neuropathy easy with credible articles from our FREE, online encyclopedia and dictionary.
Results: We identified 53 patients who had both ultrasound and MRI of whom 46 (87%) had nerve pathology diagnosed by surgical (n = 39) or clinical/electrodiagnostic (n = 14) evaluation. Ultrasound detected the diagnosed nerve pathology (true positive) more often than MRI (43/46 vs 31/46, p , 0.001). Nerve pathology was correctly excluded (true negative) with equal frequency by MRI and ultrasound (both 6/7). In 25% (13/53), ultrasound was accurate (true positive or true negative) when MRI was not. These pathologies were typically (10/13) long (,2 cm) and only occasionally (2/13) outside the MRI field of view. MRI missed multifocal pathology identified with ultrasound in 6 of 7 patients, often (5/7) because pathology was outside the MRI field of view. ...
Diseases relating to the peripheral nervous system. Mononeuropathy. Arm. median nerve. *Carpal tunnel syndrome ... Diagnosis is most often made by the elimination of other conditions, disorders or diseases. Onset usually occurs in adulthood, ...
Diseases relating to the peripheral nervous system. Mononeuropathy. Arm. median nerve. *Carpal tunnel syndrome ... "Lyme Disease Data and surveillance". Lyme Disease. Centers for Disease Control and Prevention. 2019-02-05. Retrieved April 12, ... "Lyme Disease risk areas map". Risk of Lyme disease to Canadians. Government of Canada. 2015-01-27. Retrieved May 8, 2019.. ... Lyme disease" (PDF). The New England Journal of Medicine. 370 (18): 1724-31. doi:10.1056/NEJMcp1314325. PMC 4487875. PMID ...
Autoimmune diseases. *Syndromes affecting the nervous system. *Peripheral nervous system disorders. *Cytomegalovirus-associated ... is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system.[2] The initial symptoms ... Rinaldi, Simon (June 2013). "Update on Guillain-Barré syndrome". Journal of the Peripheral Nervous System. 18 (2): 99-112. doi: ... Journal of the Peripheral Nervous System. 19 (1): 24-35. doi:10.1111/jns5.12051. PMID 24456426.. ...
Disease of the central nervous system, peripheral nervous system, and spinal column. ... The endocrine system (i.e., endocrine glands and hormones) and its diseases, including diabetes and thyroid diseases. ... Neuropsychiatry focuses on affective, cognitive and behavioral disorders attributable to diseases of the nervous system ... Autoimmune and inflammatory diseases of the joints and other organ systems, such as arthritis and other rheumatic diseases. ...
Neurology works with diseases of the central and peripheral nervous systems, such as amyotrophic lateral sclerosis (ALS) and ... the central nervous system (defined as the brain and spinal cord), and the peripheral nervous system. In many species - ... Neurosurgery and psychosurgery work primarily with surgical treatment of diseases of the central and peripheral nervous systems ... The scientific study of the biological mechanisms that underlie the disorders and diseases of the nervous system. ...
the study of the anatomy, physiology, and diseases of the nervous system ... It also deals deals with the diagnosis and treatment of all categories of disease involving the central, peripheral, and ... Neurology as the studying of the Nervous System[edit]. Does Neurology study the nervous system per se. or only its disorders ? ... study of the nervous system." Dirac66 (talk) 17:14, 21 December 2010 (UTC). *It is also the study of the nervous system and ...
... of neurostimulation of the spinal cord and peripheral nervous system for the treatment of chronic pain and ischemic diseases: ... If pain control and increased activity was achieved, a permanent system, with leads and a pulse generator, is placed.[citation ... The most common use of SCS is failed back surgery syndrome (FBSS) in the United States and peripheral ischemic pain in Europe.[ ... understood but may involve masking pain sensation with tingling by altering the pain processing of the central nervous system.[ ...
Neurology works with diseases of the central and peripheral nervous systems, such as amyotrophic lateral sclerosis (ALS) and ... the nervous system can be split into two parts, the central nervous system (brain and spinal cord), and the peripheral nervous ... Neurosurgery and psychosurgery work primarily with surgical treatment of diseases of the central and peripheral nervous systems ... The scientific study of the biological mechanisms that underlie the disorders and diseases of the nervous system. ...
Poen, polyniwropatheg diabetig, yr eryr, peripheral nervous system disease Dynodwyr. Freebase. /M/0fs8j ...
Charcot-Marie-Tooth (CMT) is the most frequent heritable disorder of the peripheral nervous system (a neuronal disease) and is ... These correlations between aaRSs and certain diseases have opened up a new door to synthesizing therapeutics.[17] ... Certain diseases' causation (such as neuronal pathologies, cancer, disturbed metabolic conditions, and autoimmune disorders) ... Francklyn C, Musier-Forsyth K, Martinis SA (September 1997). "Aminoacyl-tRNA synthetases in biology and disease: new evidence ...
... related to chronic adrenal insufficiency combined with demyelinating disease of the brain and peripheral nervous system. They ... Disease of the supra-renal capsules". London Hospital Gazette. 43: 517-8. ,access-date= requires ,url= (help) Schilder, PF ( ... Schilder's disease). Females are not affected by the condition, however due to linkage of heredity with the X chromosome, they ... Addison-Schilder's disease). Today the eponymous title recognizes the physicians who first described it (Siemerling and ...
Peripheral nervous system (PNS) diseases may be further categorized by the type of nerve cell (motor, sensory, or both) ... Neurodegenerative diseases of the central nervous system[edit]. Alzheimer's Disease (AD)[edit]. Main article: Alzheimer's ... 3 Neurodegenerative diseases of the central nervous system *3.1 Alzheimer's Disease (AD) *3.1.1 Epigenetic factors ... complex disorders linked by the degeneration of neurons in either the peripheral nervous system or the central nervous system. ...
The demyelinating diseases of the peripheral nervous system include: *Guillain-Barré syndrome and its chronic counterpart, ... A demyelinating disease is any disease of the nervous system in which the myelin sheath of neurons is damaged.[1] This damage ... Demyelinating diseases can be divided in those affecting the central nervous system (CNS) and those affecting the peripheral ... Fernández O.; Fernández V.E.; Guerrero M. (2015). "Demyelinating diseases of the central nervous system". Medicine. 11 (77): ...
Peripheral neuropathy happens when the nerves of the peripheral nervous system suffer damage due to disease, trauma to the ... Retrieved from "https://simple.wikipedia.org/w/index.php?title=Peripheral_neuropathy&oldid=4458981" ...
DiseaseEdit. Main article: Peripheral neuropathy. Diseases of the peripheral nervous system can be specific to one or more ... The peripheral nervous system is divided into the somatic nervous system, and the autonomic nervous system. The somatic nervous ... The peripheral nervous system is divided into the somatic nervous system and the autonomic nervous system. In the somatic ... The peripheral nervous system (PNS) is one of the two components of the nervous system, the other part is the central nervous ...
... (CMT) is a hereditary motor and sensory neuropathy of the peripheral nervous system characterized ... "Neurophysiologic abnormalities in children with Charcot-Marie-Tooth disease type 1A". Journal of the Peripheral Nervous System ... Further information: Charcot-Marie-Tooth disease classifications. CMT is a heterogeneous disease and the mutations linked to it ... In 2010, CMT was one of the first diseases where the genetic cause of a particular patient's disease was precisely determined ...
Reilly, Mary M.; Murphy, Sinéad M.; Laurá, Matilde (2011). "Charcot-Marie-Tooth disease". Journal of the Peripheral Nervous ... System. 16 (1): 1-14. doi:10.1111/j.1529-8027.2011.00324.x. ISSN 1529-8027. PMID 21504497. "First clinical trial for Charcot ... She began to study neuromuscular disease, in particular Charcot-Marie-Tooth disease. In 2004, she found that Vitamin C could be ... Reilly has served as President of the British Peripheral Nerve Society and the International Peripheral Nerve Society. In 2015 ...
... "nervous system" and -pathy, "disease of")[8] without modifier usually means peripheral neuropathy. ... non-sensory nervous system (i.e., the autonomic nervous system), affecting mostly the internal organs such as the bladder ... Neuritis is a general term for inflammation of a nerve[22] or the general inflammation of the peripheral nervous system. ... Peripheral neuropathy, often shortened to neuropathy, is a general term describing disease affecting the peripheral nerves, ...
They could include diseases or disorders in the central nervous system or peripheral nervous system. Examples of neuropathic ... or changes in hormonal balances associated with aging Itch can originate in the peripheral nervous system (dermal or ... Neuropathic itch can originate at any point along the afferent pathway as a result of damage of the nervous system. ... or in the central nervous system (neuropathic, neurogenic, or psychogenic). Itch originating in the skin is known as ...
In the Peripheral nervous system, the disease is more severe. While most nervous system diseases affect either CNS or PNS, this ... disease affects both, but it is the changes in the peripheral nervous system that lead to death. This occurs by axonal disease ... neuropathological features in the central and peripheral nervous system". Modern Pathology. 29 (9): 962-976. doi:10.1038/ ... In the central nervous system, accompanying the hypotonia at birth is hypoplasia of the corticospinal tracts. Another ...
... central and peripheral nervous systems, smooth muscle and hearing in humans. There have been mixed, and sometimes conflicting, ... Mitochondrial DNA can play a role in the onset of disease in a variety of ways. Point mutations in or alternative gene ... arrangements of mtDNA have been linked to several diseases that affect the heart, central nervous system, endocrine system, ... Loss of the amount of mtDNA present in the mitochondria can lead to a whole subset of diseases known as mitochondrial depletion ...
This includes the central nervous system and the peripheral nervous system. Tissue analysis comes from either surgical biopsies ... Alzheimer's disease, dementia, Huntington's disease, amyotrophic lateral sclerosis, mitochondria disease, and any disorder that ... Surgery of the peripheral nervous system is also possible, and includes the very common procedures of carpal tunnel ... Numerous other types of nerve entrapment conditions and other problems with the peripheral nervous system are treated as well.[ ...
... as well as peripheral vasoconstriction to maintain blood pressure. However, these effects accelerate disease progression, ... In the sympathetic nervous system and other components of the peripheral nervous system, these synapses are made at sites ... Together with the other component of the autonomic nervous system, the parasympathetic nervous system, the sympathetic nervous ... The sympathetic nervous system (SNS) is one of the two main divisions of the autonomic nervous system, the other being the ...
This coordination can be disrupted by damage or diseases of the central nervous system, peripheral nerves or autonomic nervous ... refers to urinary bladder problems due to disease or injury of the central nervous system or peripheral nerves involved in the ... peripheral nerve damage, Parkinson's disease, or other neurodegenerative diseases. Neurogenic bladder can be diagnosed through ... Peripheral nerves can also be damaged as a complication of major surgery of the pelvis, such as for removal of tumors. The ...
Some patients with systemic vasculitis will have their multi-organ disease spread to the peripheral nervous system; this is ... It can be as part of a systemic problem or can exist as a single-organ issue only affecting the peripheral nervous system (PNS ... Vasculitic neuropathy is a peripheral neuropathic disease. In a vasculitic neuropathy there is damage to the vessels that ... Infectious diseases: hepatitis B, hepatitis C, human immunodeficiency virus (HIV), cytomegalovirus, lyme disease, human T-cell- ...
Neurology works with diseases of the central and peripheral nervous systems, such as amyotrophic lateral sclerosis (ALS) and ... the central nervous system (defined as the brain and spinal cord), and the peripheral nervous system. In many species - ... Neurosurgery and psychosurgery work primarily with surgical treatment of diseases of the central and peripheral nervous systems ... A nervous system emerges from the assemblage of neurons that are connected to each other. The vertebrate nervous system can be ...
Wight, P. a. L. (1960). A histological study of the spinal cord and peripheral nervous system in scrapie disease of sheep ( ... As these involve the animal's nervous system he moved onto the field of neuropathology. In 1956, he returned to Britain to work ... The Histopathology of Marek's Disease Oregon Disease in Turkeys Who's Who in Commerce and Industry vol 14 SILLER, WALTER G. " ... Here he mainly worked on mainstream African animal diseases such as Heartwater and Rabies. ...
The following diseases can be treated here: orthopedic and traumatic, nervous, rheumatological, peripheral nervous system, skin ...
... motor neuron disease, peripheral neuropathy, and other diseases of the nervous system". J. Neuroimmunol. 56 (1): 27-33. doi: ... 1989). "Total, anti-viral, and anti-myelin IgG subclass reactivity in inflammatory diseases of the central nervous system". J. ... 2006). "Anti-ganglioside antibodies in coeliac disease with neurological disorders". Digestive and Liver Disease. 38 (3): 183-7 ... Antibodies to ganglioside are found to be elevated in coeliac disease. Recent studies show that gliadin can cross-link to ...
"Neurophysiologic abnormalities in children with Charcot-Marie-Tooth disease type 1A". Journal of the Peripheral Nervous System ... For other diseases, see Charcot disease (disambiguation).. Charcot-Marie-Tooth disease (CMT) is one of the hereditary motor and ... a group of varied inherited disorders of the peripheral nervous system characterized by progressive loss of muscle tissue and ... In 2010, CMT was one of the first diseases where the genetic cause of a particular patient's disease was precisely determined ...
Peripheral nervous system. Somatic. *Sensory nerve. *Motor nerve. *Cranial nerve. *Spinal nerve ... Adaszewski S1, Dukart J, Kherif F, Frackowiak R, Draganski B; Alzheimer's Disease Neuroimaging Initiative (2013). "How early ... GENESIS, a general neural simulation system.. Conferences[edit]. *Computational and Systems Neuroscience (COSYNE) - a ... physiology and cognitive abilities of the nervous system.[1][2][3][4] ...
Diseases of the endocrine system (ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases - Endocrine diseases, E00- ... and inappropriate regulation of metabolism by the central nervous system.[10] However, not all people with insulin resistance ... peripheral neuropathy, recurrent vaginal infections, and fatigue.[13] Other symptoms may include loss of taste.[24] Many people ... nervous system activity, or hormonal factors that may lead to diabetes.[34] ...
... vegetative nervous system diseases and cerebral tumors. In 1926 he was the first one who described Itsenko-Cushing's disease, ... peripheral ratio of over 3:1 when CRH is administered is indicative of Cushing's disease.[7] This test has been the gold ... The disease is often diagnosed 3-6 years after the onset of illness.[19] Several studies have shown that Cushing's disease is ... Cases of Cushing's disease are rare, and little epidemiological data is available on the disease. An 18-year study conducted on ...
... non-cholinergic nervous system (branch of the vagal system).. InflammationEdit. SP initiates expression of almost all known ... Blockade for diseases with a chronic immunological componentEdit. As increasingly documented, the SP-NK1R system induces or ... Substance P and other sensory neuropeptides can be released from the peripheral terminals of sensory nerve fibers in the skin, ... The actions of aprepitant are said to be entirely central, thus requiring passage of the drug into the central nervous system.[ ...
Neurology is concerned with diseases of the nervous system. In the UK, neurology is a subspecialty of general medicine. ... is concerned with testing the physiology or function of the central and peripheral aspects of the nervous system. These kinds ... Neuroscience includes those disciplines of science that are related to the study of the nervous system. A main focus of ... Review of systems (ROS) or systems inquiry: a set of additional questions to ask, which may be missed on HPI: a general enquiry ...
... peripheral nervous system, and central nervous system.[61][84] Many of the signs and symptoms of Lyme disease are a consequence ... Halperin JJ (June 2008). "Nervous system Lyme disease". Infectious Disease Clinics of North America. 22 (2): 261-74, vi. doi: ... Lyme disease can affect multiple body systems and produce a broad range of symptoms. Not everyone with Lyme disease has all of ... People treated only after nervous system manifestations of the disease may end up with objective neurological deficits, in ...
... exerted via the human nervous system and is a primary underlying risk factor for many diseases.[36] Straights view the medical ... Impressions are made on the peripheral afferent fiber-endings; these create sensations that are transmitted to the center of ... In 1910, D. D. Palmer theorized that the nervous system controlled health: "Physiologists divide nerve-fibers, which form the ... affects the nervous system and may lead to reduced function, disability or illness."[50][51] ...
As such, it happens automatically (though there are exceptions in some disease states) and does not need conscious control or ... Central nervous system. *Intracerebral. *Intrathecal. *Epidural. Circulatory,. musculoskeletal. *Intravenous. *Intracardiac. * ...
Mixed connective tissue disease - a disease of the autoimmune system, also undifferentiated connective tissue disease. ... tissue neoplasms including sarcomas such as hemangiopericytoma and malignant peripheral nerve sheath tumor in nervous tissue. ... including the nervous system. In the central nervous system, the three outer membranes (the meninges) that envelop the brain ... "Nutrition, Metabolism and Cardiovascular Diseases. 17 (2): 125-139. doi:10.1016/j.numecd.2006.10.005. PMC 4426988. PMID ...
... that affects multiple systems, such as the nervous and integumentary system.[2] Other examples of pleiotropy are albinism, ... A common example of pleiotropy is the human disease phenylketonuria (PKU). This disease causes mental retardation and reduced ... "Transcriptome Profiling of Peripheral Blood in 22q11.2 Deletion Syndrome Reveals Functional Pathways Related to Psychosis and ... Unconverted phenylalanine builds up in the bloodstream and can lead to levels that are toxic to the developing nervous system ...
Neurosteroids are synthesized in the central nervous system (CNS) and the peripheral nervous system (PNS) from cholesterol and ... "Neuropsychiatric Disease and Treatment. 1 (4): 329-43. PMC 2424120. PMID 18568113.. .mw-parser-output cite.citation{font-style: ... Baulieu EE (1997). "Neurosteroids: of the nervous system, by the nervous system, for the nervous system". Recent Progress in ... GABA is a major inhibitory neurotransmitter in the central nervous system. Upon binding, it triggers the GABAA receptor to open ...
The smooth muscle of the bladder, known as the detrusor, is innervated by sympathetic nervous system fibers from the lumbar ... When the sacral dorsal roots are cut in experimental animals or interrupted by diseases of the dorsal roots such as tabes ... central and peripheral neuronal control of the micturition cycle". Anat. Embryol. 192 (3): 195-209. doi:10.1007/BF00184744. ... Physiologically, urination involves coordination between the central, autonomic, and somatic nervous systems. Brain centers ...
Tikal K, Hrabánková M (June 1993). "[Indications for antidepressive agents in relation to diseases of the cardiovascular system ... Moclobemide has good penetration across the blood brain barrier with peak plasma levels within the central nervous system ... except that in doses of 400 mg or higher peripheral reaction time may be impaired.[68] Peripheral oedema has been associated ... Alderman CP, Callary JA, Kent AL (July 1992). "Peripheral oedema associated with moclobemide". Med. J. Aust. 157 (2): 144. PMID ...
... including the metabolic system, cardiovascular system, immune system, reproductive system and central nervous system. The HPA ... During an immune response, proinflammatory cytokines (e.g. IL-1) are released into the peripheral circulation system and can ... Stress and disease[edit]. The HPA axis is involved in the neurobiology of mood disorders and functional illnesses, including ... At the hypothalamus, fear-signaling impulses activate both the sympathetic nervous system and the modulating systems of the HPA ...
Malignant neoplasms of the brain and nervous system (1.5%). *Retinal detachment (1.4%) ... Stargardt's disease. *Uveitis: is a group of 30 intraocular inflammatory diseases[44] caused by infections, systemic diseases, ... with corrective glasses or central visual acuity of more than 20/200 if there is a visual field defect in which the peripheral ... a b c Morello, C. M. "Etiology and Natural History of Diabetic Retinopathy: An Overview." American Journal of Health-System ...
... particularly the muscles and nervous system. In most cases, the signs and symptoms of this disorder appear during childhood or ... Common symptoms include, myoclonus, myopathy, spasticity, epilepsy, peripheral neuropathy, dementia, ataxia, atrophy, and more. ... see also mitochondrial diseases. This article incorporates text from the United States National Library of Medicine, which is ...
Centers for Disease Control and Prevention (CDC) - Centers for Medicare and Medicaid Services (CMS) - central nervous system - ... pelvic inflammatory disease - peptide - perianal - perinatal - perinatal transmission - peripheral neuritis - peripheral ... efficacy - empirical - encephalitis - end-stage disease - endemic - endogenous - endoscopy - endotoxin - endpoint - enteric - ... NAT - National Cancer Institute (NCI) - National Institute of Allergy and Infectious Diseases (NIAID) - National Institute of ...
The US Food and Drug Administration's Peripheral and Central Nervous System Drugs Advisory Committee rejected the drug in June ... or Corino de Andrade's disease,[1] is an autosomal dominant[2] neurodegenerative disease. It is a form of amyloidosis, and was ... especially in the peripheral nervous system, causing a progressive sensory and motor polyneuropathy. ... Autonomic testing, including quantitative sweat testing, can reveal involvement of the autonomic nervous system.[7] ...
... and disease of the spleen and central nervous system. They are rare in the blood, but numerous in the mucous membranes of the ... Neutrophilia is an increase in the absolute neutrophil count in the peripheral circulation. Normal blood values vary by age.[15 ... Chronic inflammation - especially juvenile rheumatoid arthritis, rheumatoid arthritis, Still's disease, Crohn's disease, ... are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign ...
... of pre-synaptic α2 receptors facilitates the release of several neurotransmitters in the central and peripheral nervous system ... treatment or prevention of disease": 21 U.S.C. § 321(g)(1)(B).[23] However the legal position is not entirely straightforward,[ ... "Yohimbine pharmacokinetics and interaction with the sympathetic nervous system in normal volunteers". European Journal of ... Rao MR, Palada MC, Becker BN (2013). "Medicinal and aromatic plants in agroforestry systems". In Nain PK, Rao MR, Buck LE (eds ...
A procedure known as targeted lung denervation, which involves decreasing the parasympathetic nervous system supply of the ... those with a peripheral oxygen saturation less than 92%, and those with symptoms of congestive heart failure.[22] In areas of ... Chronic obstructive pulmonary disease. Other names. Chronic obstructive lung disease (COLD), chronic obstructive airway disease ... Most cases of COPD are a mixture of both diseases.. *^ "Chronic obstructive pulmonary disease (COPD)". WHO. Retrieved 5 June ...
BDNF acts on certain neurons of the central nervous system and the peripheral nervous system, helping to support survival of ... Alzheimer's disease,[71] Huntington's disease,[72] Rett syndrome,[73] and dementia,[74] as well as anorexia nervosa[75] and ... Given that BDNF is critical for the survival of central nervous system (CNS) and peripheral nervous system (PNS) neurons and ... peripheral nervous system development. • memory. • nerve development. • nerve growth factor signaling pathway. • regulation of ...
Peripheral[edit]. The peripheral olfactory system consists mainly of the nostrils, ethmoid bone, nasal cavity, and the ... These diseases have more moderate effects on the olfactory system than Alzheimer's or Parkinson's diseases.[39] Furthermore, ... "Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats". ... Most mammals and reptiles have a main olfactory system and an accessory olfactory system. The main olfactory system detects ...
... of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system". ... Role in disease[edit]. Mutations in the first SOD enzyme (SOD1) can cause familial amyotrophic lateral sclerosis (ALS, a form ... This was cut short by concerns about prion disease.[citation needed] An SOD-mimetic agent, TEMPOL, is currently in clinical ... In biological systems, this means that its main reactions are with itself (dismutation) or with another biological radical such ...
Unlike the peripheral nervous system, the central nervous system is unable to regenerate damaged axons, so its synaptic ... Transplantation of stem cells is also known to cause toxicity and graft-versus-host disease (GVHD). Apoptotic cells have been ... due to their regenerate properties in the peripheral nervous system and their presence in the central nervous system.[2] OECs ... as they form the fascicles through which axons grow from the peripheral nervous system into the central nervous system.[5] ...
... kava has been used in the traditional medicine of the South Pacific Islands for central nervous system and peripheral effects.[ ... No information is available on the potential for kava beverage consumption to impact on the incidence of chronic disease. ... Ligresti A, Villano R, Allarà M, Ujváry I, Di Marzo V (2012). "Kavalactones and the endocannabinoid system: the plant-derived ... United States Centers for Disease Control and Prevention (2002). "Hepatic Toxicity Possibly Associated with Kava-Containing ...
The system was based on the existing counties (now known as the historic counties, since the major boundary changes of 1974). ... The English army suffered badly from disease, and Henry was not even present at the one notable victory, the Battle of the ... At best, the elite-dominance model might apply in the peripheral areas of the settlement territory, where an immigration ... The king became increasingly nervous about the possibility of his daughter Mary inheriting the throne, as England's one ...
Sontheimer, Harald (2015). Diseases of the Nervous System. Academic Press. p. 170. ISBN 978-0-12-800403-6. . Archived from the ... that the person has a form of peripheral neuropathy (damage to peripheral nerves) or myopathy (muscle disease) rather than ALS ... Disease Primers. 3 (17071): 17071. doi:10.1038/nrdp.2017.71. PMID 28980624.. *^ a b c d e f g h i j k l m n o p q r s t u v van ... Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND) or Lou Gehrig's disease, is a specific disease ...
Ganglioneuroma, a tumor in the nerve cells of the peripheral nervous system[5] ... "Diseases of the adrenal medulla". Acta Physiologica. 192 (2): 325-335. doi:10.1111/j.1748-1716.2007.01809.x. PMC 2576282. PMID ... As a cluster of neuron cell bodies, the adrenal medulla is considered a modified ganglion of the sympathetic nervous system.[2] ... These cells are intimately connected with the sympathetic division of the autonomic nervous system (ANS). These adrenal ...
World Health Organization (1990). "Interim proposal for a WHO staging system for HIV infection and disease". WHO Wkly Epidem. ... Luft BJ, Chua A (2000). "Central Nervous System Toxoplasmosis in HIV Pathogenesis, Diagnosis, and Therapy". Curr. Infect. Dis. ... "Symptom management and self-care for peripheral neuropathy in HIV/AIDS". AIDS Care 19 (2): 179-89. doi:10.1080/ ... 35.0 35.1 Tang J, Kaslow RA (2003). "The impact of host genetics on HIV infection and disease progression in the era of highly ...
Diseases : C-Reactive Protein, Peripheral Nerve Diseases, Peripheral Nervous System Diseases. Therapeutic Actions : Mud therapy ... Diseases : Celiac Disease, Gluten Sensitivity, Neuropathic Pain, Peripheral Nervous System Diseases, Peripheral Neuropathies ... 3 Abstracts with Peripheral Nervous System Diseases Research. Filter by Study Type. Human Study. ... 1 Therapeutic Actions Researched for Peripheral Nervous System Diseases Name. AC. CK. Focus. ...
515 Studies found for: Recruiting, Not yet recruiting, Available Studies , Peripheral Nervous System Diseases ... Recruiting, Not yet recruiting, Available Studies , Peripheral Nervous System Diseases (515 records) ... Establishing of Neuronal-like Cells From Patients With Cisplatin-Induced Peripheral Neuropathy. *Peripheral Nervous System ... Chemotherapy Induced Peripheral Neuropathy (CIPN). *Chemotherapy-induced Peripheral Neuropathy. *Other: Arm 1: Investigational ...
"Peripheral Nervous System Diseases" by people in Harvard Catalyst Profiles by year, and whether "Peripheral Nervous System ... Peripheral Nervous System Diseases*Peripheral Nervous System Diseases. *Peripheral Nervous System Disease ... "Peripheral Nervous System Diseases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ... Below are the most recent publications written about "Peripheral Nervous System Diseases" by people in Profiles. ...
Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of ... Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of ... seeks to generate scientific advancements addressing the role of the autonomic nervous system in the regulation of peripheral ... may propose to develop resources in the form of novel tools or methodologies that when applied to the autonomic nervous system ...
To investigate how abnormal GM2 catabolism affects the peripheral nervous system in a mouse model of Sandhoff disease (Hexb ... or compositional abnormalities in the peripheral nervous system of the murine model for Sandhoff disease, but do show the ... and lipid composition of the peripheral nervous system. Results: We detected no significant difference in signal impulse ... Background: Sandhoff disease is an inherited lysosomal storage disease caused by a mutation in the gene for the β-subunit (Hexb ...
The spinal cord as organizer of disease processes: II. The peripheral autonomic nervous system. The Journal of the American ... Korr I. The spinal cord as organizer of disease processes: II. The peripheral autonomic nervous system. J Am Osteopath Assoc ... The spinal cord as organizer of disease processes: II. The peripheral autonomic nervous system ... The spinal cord as organizer of disease processes: II. The peripheral autonomic nervous system ...
Journal of the Peripheral Nervous System" on DeepDyve, the largest online rental service for scholarly research with thousands ... Add Journal to My Library Journal of the Peripheral Nervous System , Volume 23 (1) - Jan 1, 2018 ... http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of the Peripheral Nervous System Wiley http://www.deepdyve. ... Charcot‐Marie‐Tooth (CMT) disease is the most common inherited peripheral neuropathy characterized by progressive distal muscle ...
Patients with Fabry disease often remain undiagnosed until severe complications involving the kidney, heart, peripheral nerves ... Results: We describe the neuropathy in Fabry disease, focusing on peripheral small fiber dysfunction - the hallmark of early ... Peripheral pain can be chronic and/or occur as provoked attacks of excruciating pain. Manifestations of dysfunction of small ... The clinical course of peripheral pain is summarized, and the importance of medical history-taking, including family history, ...
Peripheral nervous system disease in Systemic Lupus Erythematosus: Results from an international, inception cohort study. ... Peripheral nervous system disease in Systemic Lupus Erythematosus: Results from an international, inception cohort study ... Peripheral nervous system disease in Systemic Lupus Erythematosus: Results from an international, inception cohort study. ... associations and outcomes in different types of peripheral nervous system (PNS) disease. Methods Patients were evaluated ...
Peripheral nervous system diseases explanation free. What is Peripheral nervous system diseases? Meaning of Peripheral nervous ... system diseases medical term. What does Peripheral nervous system diseases mean? ... Looking for online definition of Peripheral nervous system diseases in the Medical Dictionary? ... Related to Peripheral nervous system diseases: Peripheral neuropathy, Central nervous system diseases, Spinal cord diseases ...
"Peripheral Nervous System Diseases" by people in UAMS Profiles by year, and whether "Peripheral Nervous System Diseases" was a ... Peripheral Nervous System Diseases*Peripheral Nervous System Diseases. *Peripheral Nervous System Disease ... "Peripheral Nervous System Diseases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ... Below are the most recent publications written about "Peripheral Nervous System Diseases" by people in Profiles over the past ...
Build: Sat Nov 17 23:53:08 EST 2018 (commit: a759bb7). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
Background: Chemotherapy-induced peripheral neuropathy is a frequent side-effect of drugs that are used in the treatment of ... Background: Chemotherapy-induced peripheral neuropathy is a frequent side-effect of drugs that are used in the treatment of ... Background: Chemotherapy-induced peripheral neuropathy is a frequent side-effect of drugs that are used in the treatment of ... Chemotherapy-induced peripheral neuropathy (CIPN) is a serious dose-limiting side-effect without any FDA-approved treatment ...
Ways in which the peripheral nervous system is vulnerable. So, its vulnerable to say a, large molecules such as botulinum ... If you cut a, an axon in the peripheral nervous system, it can repair itself. ... system tends to be far more vulnerable, than is the central nervous system. ... Peripheral Diseases. Pour visualiser cette vidéo, veuillez activer JavaScript et envisagez une mise à niveau à un navigateur ...
Therefore it is very important to know how you will overcome you peripheral nervous system diseases. This peripheral nervous ... Peripheral nervous system disease is the major disease that can lead to madness if proper measures are not taken within the ... It is important for to know how to overcome your peripheral nervous system disease since it is one of the disease which affects ... These nutrients are essential for the live of the nervous system. Also for you to overcome your peripheral nervous system ...
Peripheral Nerve Diseases; Peripheral Neuropathies. On-line free medical diagnosis assistant. Ranked list of possible diseases ... A similarity measure between symptoms and diseases is provided. ... Peripheral Nervous System Diseases (Peripheral Nerve Diseases; ... Ranked list of diseases related to "Peripheral Nervous System Diseases"Drugs, active principles and "Peripheral Nervous System ... Peripheral Neuropathies). Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of ...
NHS Choices: Neurofibromatosis Provides information on this genetic disorder that affects the nervous system and the skin. ... as well as background information on the disease, and links to related resources. ...
Nervous system infections caused by tick-borne spirochetes of the BORELLIA BORGDORFERI GROUP. The disease may affect elements ... Definition of the term Peripheral Nervous System Lyme Disease: ... Autonomic Peripheral Nervous System Diseases. Diseases of the ... medical condition involving peripheral nervous system.. » Find the definition of Peripheral Nervous System Lyme Disease in ... Peripheral Nervous System Lyme Disease:. Nervous system infections caused by tick-borne spirochetes of the BORELLIA BORGDORFERI ...
Peripheral Nervous System Damage in Experimental Chronic Chagas' Disease Cappa S. M. González, O. P. Sanz, L. A. Muller, H ... were compared in their ability to cure two distinct Trypanosoma brucei brucei central nervous system murine model infections. ... Reservoir Competence of White-Footed Mice for Lyme Disease Spirochetes James G. Donahue, Joseph Piesman and Andrew Spielman ... Methyl Ester Alone and in Combination with Suramin against Trypanosoma brucei brucei Central Nervous System Models C. J. Bacchi ...
Peripheral Nervous System Diseases. D010523. EFO:0003100. peripheral neuropathy. 3. ClinicalTrials. Pneumococcal Infections. ... Peripheral Nervous System Diseases. D010523. EFO:0004149. neuropathy. 3. ClinicalTrials. Renal Insufficiency, Chronic. D051436 ... Kidney Diseases. D007674. EFO:0003086. kidney disease. 3. ClinicalTrials. Leukemia, Hairy Cell. D007943. EFO:1000956. hairy ... Crohn Disease. D003424. EFO:0000384. Crohns disease. 1. ClinicalTrials. Leukemia, Lymphoid. D007945. EFO:0004289. lymphoid ...
Peripheral Nervous System Diseases. D010523. EFO:0003100. peripheral neuropathy. 2. ClinicalTrials. Carcinoma, Non-Small-Cell ... Digestive System Diseases. D004066. EFO:0000405. digestive system disease. 1. ClinicalTrials. Gallbladder Neoplasms. D005706. ... Liver Diseases. D008107. EFO:0001421. liver disease. 1. ClinicalTrials. Ovarian Neoplasms. D010051. Orphanet:398934. Malignant ... Hodgkin Disease. D006689. EFO:0000183. Hodgkins lymphoma. 2. ClinicalTrials. Leukemia, Myeloid, Acute. D015470. EFO:0000222. ...
Peripheral Nervous System Involvement in Patients With Behçet Disease. Atasoy, Huseyin Tugrul; Tunc, Tugba Oruc; Unal, Aysun ... The Pathological Presentations of Neuro-Behçet Disease: A Case Report and Review of the Literature. Haghighi, Afshin Borhani; ... Migraine With Aura Is a Risk Factor for Cardiovascular and Cerebrovascular Disease: A Critically Appraised Topic. Wingerchuk, ...
lead; diseases of peripheral nervous system; diseases of central nervous system; organolead compounds. ... Workers reported symptoms that predominantly involved central (CNS) and peripheral (PNS) nervous systems. Findings for which no ...
Diseases relating to the peripheral nervous system. Mononeuropathy. Arm. median nerve. *Carpal tunnel syndrome ... Diagnosis is most often made by the elimination of other conditions, disorders or diseases. Onset usually occurs in adulthood, ...
The demyelinating diseases of the peripheral nervous system include: *Guillain-Barré syndrome and its chronic counterpart, ... A demyelinating disease is any disease of the nervous system in which the myelin sheath of neurons is damaged.[1] This damage ... Demyelinating diseases can be divided in those affecting the central nervous system (CNS) and those affecting the peripheral ... Fernández O.; Fernández V.E.; Guerrero M. (2015). "Demyelinating diseases of the central nervous system". Medicine. 11 (77): ...
Peripheral neuropathy and central nervous system lesions in canine globoid-cell leukodystrophy (Krabbes disease). South Dakota ... Peripheral neuropathy and central nervous system lesions in canine globoid-cell leukodystrophy (Krabbes disease). / Kurtz, H. ... title = "Peripheral neuropathy and central nervous system lesions in canine globoid-cell leukodystrophy (Krabbes disease).", ... T1 - Peripheral neuropathy and central nervous system lesions in canine globoid-cell leukodystrophy (Krabbes disease). ...
Learn about neuropathy and more than 100 other types of peripheral nerve disorders. ... Peripheral nerves are nerves outside your brain and spinal cord. ... Peripheral Nervous System Diseases (National Institutes of ... What Are the Parts of the Nervous System? (Eunice Kennedy Shriver National Institute of Child Health and Human Development) ... Your peripheral nerves are the ones outside your brain and spinal cord. Like static on a telephone line, peripheral nerve ...
Peripheral Nervous System Diseases. Neuromuscular Diseases. Nervous System Diseases. Proteostasis Deficiencies. Metabolic ... Heredodegenerative Disorders, Nervous System. Neurodegenerative Diseases. Genetic Diseases, Inborn. Metabolism, Inborn Errors. ... Condition or disease Intervention/treatment Phase TTR-mediated Amyloidosis Amyloidosis, Hereditary Amyloid Neuropathies, ... Genetic and Rare Diseases Information Center resources: Familial Transthyretin Amyloidosis Amyloid Neuropathy ...
Peripheral Nervous System Diseases. Neuromuscular Diseases. Nervous System Diseases. Acetaminophen. Analgesics, Non-Narcotic. ... Sensory System Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. Antipyretics. ... Condition or disease Intervention/treatment Phase Cervical Radiculopathy Radicular Pain Acute Neck Pain Cervicobrachial Pain ...
Peripheral Nervous System Diseases/therapy , Peripheral Nervous System Diseases/diagnosis , Peripheral Nervous System Diseases/ ... Peripheral Nervous System Diseases / Early Diagnosis / Myositis Type of study: Screening_studies Limits: Humans Language: ... Peripheral Nervous System Diseases / Early Diagnosis / Myositis Type of study: Screening_studies Limits: Humans Language: ... Humans , Polyneuropathies/etiology , Polyneuropathies/virology , Peripheral Nervous System Diseases/virology , Myositis/ ...
  • Also searched for Peripheral neuropathy . (clinicaltrials.gov)
  • Descriptive Statistics to measure the degree of peripheral neuropathy in the two arms based on the PQAS score. (clinicaltrials.gov)
  • Staff NP, Fehrenbacher JC, Caillaud M, Damaj MI, Segal RA, Rieger S. Pathogenesis of paclitaxel-induced peripheral neuropathy: A current review of in vitro and in vivo findings using rodent and human model systems. (harvard.edu)
  • Liu, Xiaomin 2018-01-01 00:00:00 Charcot‐Marie‐Tooth (CMT) disease is the most common inherited peripheral neuropathy characterized by progressive distal muscle weakness and atrophy with decreased or absent tendon reflexes. (deepdyve.com)
  • Charcot‐Marie‐Tooth (CMT) disease is the most common inherited peripheral neuropathy characterized by progressive distal muscle weakness and atrophy with decreased or absent tendon reflexes. (deepdyve.com)
  • Small, unmyelinated nerve fibers are particularly affected and small fiber peripheral neuropathy often clinically manifests at young age. (uni-wuerzburg.de)
  • Results: We describe the neuropathy in Fabry disease, focusing on peripheral small fiber dysfunction - the hallmark of early neurologic involvement in this disorder. (uni-wuerzburg.de)
  • Conclusions: Our recommendations can assist in diagnosing Fabry small fiber neuropathy early, and offer clinicians guidance in controlling peripheral pain. (uni-wuerzburg.de)
  • Multivariate Cox regressions suggested longer time to resolution in patients with prior history of neuropathy, older age at SLE diagnosis, higher SLEDAI‐2K scores, and for peripheral neuropathy versus other neuropathies. (ucl.ac.uk)
  • By physician assessment, the majority of neuropathies resolved or improved over time and this was associated with improvements in SF‐36 summary scores for peripheral neuropathy and mononeuropathy. (ucl.ac.uk)
  • Analysis of youtube as a source of information for peripheral neuropathy. (uams.edu)
  • Background: Chemotherapy-induced peripheral neuropathy is a frequent side-effect of drugs that are used in the treatment of cancer. (isharonline.org)
  • Chemotherapy-induced peripheral neuropathy (CIPN) is a serious dose-limiting side-effect without any FDA-approved treatment option. (isharonline.org)
  • AIM: To identify which of the examined agents or modalities were effective in the management of chemotherapy-induced peripheral neuropathy (CIPN). (isharonline.org)
  • Peripheral neuropathy and central nervous system lesions in canine globoid-cell leukodystrophy (Krabbe's disease). (umn.edu)
  • Hypothyroidism: Can It Cause Peripheral Neuropathy? (medlineplus.gov)
  • 1.Type 2 diabetic peripheral neuropathy;2. (chinastemcell.com.cn)
  • Thus, the presence and levels of scrum anti-PNS antibodies in leprosy appear to be unrelated to parameters of disease activity, neuropathy in particular, and do not seem to be critically involved in the pathogenesis of nerve damage. (ilsl.br)
  • He had a history of high blood lead levels and peripheral neuropathy documented by electromyography. (elsevier.es)
  • MayoClinic.com explains that erectile dysfunction, constipation and bladder problems continue the roster of misfortunes visited upon those who live with diabetic neuropathy of the autonomic nervous system. (livestrong.com)
  • Screening occupational populations for asymptomatic or early peripheral neuropathy. (cdc.gov)
  • Available techniques for screening workers at risk for peripheral neuropathy from exposure to neurotoxins are of three types: those based on neurological history, those based on neurological examination, and those based on neurophysiological or electrodiagnostic testing. (cdc.gov)
  • The purpose of this study is to determine if acetyl-L-carnitine (ALC) reduces pain, numbness, and tingling in the feet and legs of patients with nucleoside reverse transcriptase inhibitor (NRTI)-associated peripheral neuropathy. (clinicalconnection.com)
  • Distal symmetric peripheral neuropathy (DSPN) is the most frequent neurologic complication of HIV infection and its treatments. (clinicalconnection.com)
  • Neuropathy, also known as peripheral neuropathy, is disease in the peripheral nerves the nerves that lead to and from the spinal cord and connect with all the various parts of the body. (healthcommunities.com)
  • The feet and legs are most often affected by peripheral neuropathy, but as time progresses without treatment the hands may become affected as well. (rarediseases.org)
  • Participants had experienced moderate or severe neuropathic pain for at least three months due to cancer, cancer treatment, postherpetic neuralgia, peripheral diabetic neuropathy, spinal cord injury, or polyneuropathy. (mendeley.com)
  • About thirty percent of all cancer patients receiving chemotherapy suffer from chemotherapy-induced peripheral neuropathy (CIPN), which makes CIPN one of the most significant side effects of many widely used antineoplastic drugs. (uni-heidelberg.de)
  • Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves. (harvard.edu)
  • To investigate how abnormal GM2 catabolism affects the peripheral nervous system in a mouse model of Sandhoff disease (Hexb-/-), we examined the electrophysiology of dissected sciatic nerves, structure of central and peripheral myelin, and lipid composition of the peripheral nervous system. (harvard.edu)
  • Patients with Fabry disease often remain undiagnosed until severe complications involving the kidney, heart, peripheral nerves and/or brain have arisen. (uni-wuerzburg.de)
  • Your peripheral nerves are the ones outside your brain and spinal cord. (medlineplus.gov)
  • Chronic work related syndrome is typical of many injuries to bones, joints, muscles and peripheral nerves. (euroasia-science.ru)
  • In the somatic nervous system, the cranial nerves are part of the PNS with the exception of the optic nerve (cranial nerve II), along with the retina . (wikipedia.org)
  • The somatic system includes the sensory nervous system and the somatosensory system and consists of sensory nerves and somatic nerves, and many nerves which hold both functions. (wikipedia.org)
  • Although the importance of evaluating the distal sensory nerves has gained much attention, no study has addressed the issue whether NCS parameters of these distal sensory nerves in IGT patients are significantly different from those of healthy controls with no medical condition, and whether these parameters are different to those with patients with diabetes mellitus, who have no previous history of peripheral polyneuropathy. (bioportfolio.com)
  • Peripheral nerves may be involved by Guillain-Barre, and Chr Inflammatory Polyneuritis. (healthtap.com)
  • Pertinent cases are reported, to illustrate the effect of impairment of this blood supply in producing ischemia of the brain, spinal cord, and peripheral nerves. (biomedsearch.com)
  • The autonomic nervous system is divided into sympathetic and parasympathetic nerves. (livestrong.com)
  • However, David S. Goldstein, M.D., of the National Institute of Neurological Disorders and Stroke has reported that Parkinson's disease also damages sympathetic nerves to the heart. (livestrong.com)
  • A neurological surgeon is a physician who surgically treats disorders of the nervous system, which is comprised of the brain, spinal cord and nerves. (vitals.com)
  • HIV can cause damage to both the central nervous system the brain and spinal cord and the peripheral nervous system the nerves leading to and from the central nervous system. (healthcommunities.com)
  • If the HIV infection affects the peripheral nervous system, then the nerves and muscles show various signs of dysfunction. (healthcommunities.com)
  • In many cases, the first apparent symptom of POEMS syndrome is disease affecting many nerves (polyneuropathy). (rarediseases.org)
  • The peripheral nervous system consists of all the motor and sensory (sensorimotor) nerves that connect the brain and spinal cord to the rest of the body (i.e., the nerves outside the central nervous system). (rarediseases.org)
  • any disease or disorder of the nerves. (thefreedictionary.com)
  • Substance P is produced in both the central nervous system (CNS) - the brain and spinal cord - and in our peripheral nervous system (PNS) - all the other nerves and nerve cells that send signals to the brain. (medicalxpress.com)
  • Andermann syndrome, also known as agenesis of corpus callosum with neuronopathy (ACCPN) and Charlevoix disease, among other names, is a very rare neurodegenerative genetic disorder that damages the nerves used to control muscles and related to sensation and is often associated with agenesis of the corpus collosum. (wikipedia.org)
  • This occurs by axonal disease paralyzing the skeletal muscles, including the respiratory muscles as a result of axonal damage in peripheral nerves. (wikipedia.org)
  • The nerves connect to the peripheral nervous system. (wikipedia.org)
  • This targeted FOA specifically seeks to generate scientific advancements addressing the role of the autonomic nervous system in the regulation of peripheral metabolism and its role in diabetes, obesity and related metabolic disease. (nih.gov)
  • Interdisciplinary teams may propose to develop resources in the form of novel tools or methodologies that when applied to the autonomic nervous system will contribute to elucidating its functional role in metabolism. (nih.gov)
  • Alternatively, teams may focus on novel approaches to address specific knowledge gaps or scientific questions that will significantly contribute to our understanding of role of the autonomic nervous system in metabolism with the goal of accelerating scientific progress in the treatment and prevention of metabolic disease. (nih.gov)
  • Manifestations of dysfunction of small autonomic fibers may include, among others, impaired sweating, gastrointestinal dysmotility, and abnormal Background: Fabry disease is an inherited metabolic disorder characterized by progressive lysosomal accumulation of lipids in a variety of cell types, including neural cells. (uni-wuerzburg.de)
  • The peripheral nervous system is divided into the somatic nervous system and the autonomic nervous system . (wikipedia.org)
  • [4] The autonomic nervous system is an involuntary control of smooth muscle and glands . (wikipedia.org)
  • The autonomic nervous system is a 'self-regulating' system which influences the function of organs outside voluntary control, such as the heart rate , or the functions of the digestive system . (wikipedia.org)
  • It can affect the feeling of your hands and feet and less often after very prolonged diabetes can affect your autonomic nervous system and lead to stomach problems or syncopal issues. (healthtap.com)
  • The autonomic nervous system (ANS) controls automatic body functions such as heart rate, blood pressure, bowel, bladder and sexual function. (bidmc.org)
  • Diabetes and Parkinson's disease are two examples of chronic conditions that can lead to autonomic dysfunction. (bidmc.org)
  • The aim of this review is to evaluate the available data on clinical manifestations, pathogenesis , investigations and the therapeutic implication for peripheral nervous system [PNS] neuropathies complications of HIV / AIDS . (bvsalud.org)
  • WHO HQ Library catalog › Results of search for 'su:{Nervous system diseases} and au:WHO Study Group on Peripheral Neuropathies. (who.int)
  • Because of the accessibility of the peripheral nervous system (PNS) to direct physiological and pathological study, neuropathies have traditionally played a unique role in developing our understanding of basic mechanism of nervous system injury and repair. (nih.gov)
  • The spinal cord as organizer of disease processes: II. (jaoa.org)
  • This peripheral nervous diseases affect the sensory, motor and the relay neurons which are responsible for sensing and transferring of information from the spinal cord to the brain and vice versa. (howtohint.com)
  • This work records the results of a study of the spinal cords, spinal sensory ganglia, sympathetic ganglia, Gasserian ganglia and neurones in the adrenal glands of sheep affected with scrapie disease. (ed.ac.uk)
  • The central nervous system consists of the brain and spinal cord. (medicalnewstoday.com)
  • We will look at the types of cells involved, different regions within the brain, spinal circuitry, and how the CNS can be affected by disease and injury. (medicalnewstoday.com)
  • The sensory nervous system is part of the somatic nervous system and transmits signals from senses such as taste and touch (including fine touch and gross touch) to the spinal cord and brain. (wikipedia.org)
  • Barkhof's research interests focus on childhood white matter disease, multiple sclerosis (spinal cord MRI, gray matter, atrophy, and histopathology correlations), aging (white matter lesions and microbleeds), and dementia (structural, functional, and molecular MR and PET). (springer.com)
  • Any of various diseases involving the brain, spinal cord, and peripheral nervous system. (dictionary.com)
  • According to Tim Newman, the central nervous system is made up of the brain and spinal cord, it collects information from the entire body and it also controls functions throughout the entire body. (wikipedia.org)
  • A thorough physical examination (e. g., angiokeratoma, corneal opacities) and simple non-invasive sensory perception tests could provide clues to the diagnosis of Fabry disease. (uni-wuerzburg.de)
  • Diagnosis is most often made by the elimination of other conditions, disorders or diseases. (wikipedia.org)
  • Cerebrospinal fluid analysis (CSF) can be extremely beneficial in the diagnosis of central nervous system infections. (wikipedia.org)
  • Diagnosis of peripheral nerve injuries is based on the history and clinical assessment of the motor and sensory function of the affected nerve(s). (merckvetmanual.com)
  • Further developments in gene therapy would allow the progression and optimization of future applications regarding vector tools, therapeutic constructs, delivery systems, design of preclinical evaluation and clinical trials. (frontiersin.org)
  • The aim of this Research Topic is to present the state of the art of gene therapy for neurological diseases from a clinical perspective, and address most key aspects representing the current focus of research of the international scientific community. (frontiersin.org)
  • The clinical course of peripheral pain is summarized, and the importance of medical history-taking, including family history, is highlighted. (uni-wuerzburg.de)
  • Objectives In a multi‐ethnic/racial, prospective SLE inception cohort, to determine the frequency, clinical characteristics, associations and outcomes in different types of peripheral nervous system (PNS) disease. (ucl.ac.uk)
  • Infant Botulism Treatment and Prevention Program Official sites for physicians to obtain BabyBIG, an FDA approved orphant drug for treatment of infant botulism type A and B. Also provides parent support forum and medical/clinical information on the disease. (inter.rs)
  • the frequencies of the symptom both as an initial sign and as observed during the clinical course of the disease were examined. (biomedsearch.com)
  • It is therefore possible that the extent of NK T cell alteration may be a critical factor which would define the clinical and pathological features of autoimmune disease. (jimmunol.org)
  • In close collaboration with the Department of Neuroradiology (www.klinikum.uni-heidelberg.de/MR-Neurographie.116270.0.html), we aim at defining more sensitive diagnostic parameters to detect lesions to the peripheral nervous system at possibly early stages of the disease and to predict response to different therapeutic options as well as to the clinical outcome more reliably. (uni-heidelberg.de)
  • Autopsy examination of 8 cases has shown both developmental and degenerative neuropathologic features in this disease, consistent with clinical duality as both a neurodevelopmental and neurodegenerative disorder. (wikipedia.org)
  • In the most well known example of demyelinating disease, multiple sclerosis , evidence has shown that the body's own immune system is at least partially responsible. (wikipedia.org)
  • As has been argued, diseases such as multiple sclerosis cannot be accounted for by autoimmune deficiency alone, but strongly imply the influence of flawed developmental processes in disease pathogenesis. (wikipedia.org)
  • Fatigue is intrinsic to Multiple Sclerosis (MS) and represents the most common symptom experienced by patients along the course of the disease [ 1 ], contributing to disability and to the worsening of their daily quality of life [ 2 , 3 ]. (hindawi.com)
  • A new study suggests that patients with relapsing-remitting multiple sclerosis can experience long-term increases in disability in the absence of disease relapses. (nature.com)
  • Using a single-strand conformation polymorphism method, we demonstrate that a great reduction of Vα24JαQ NK T cells in the peripheral blood is an immunological hallmark of multiple sclerosis, whereas it is not appreciable in other autoimmune/inflammatory diseases such as chronic inflammatory demyelinating polyneuropathy. (jimmunol.org)
  • For example, Multiple Sclerosis (MS) is an inflammatory neurodegenerative disease, where the body initiate an inflammatory reaction in the central nervous system, and causes damage to neurons. (wikipedia.org)
  • Workers reported symptoms that predominantly involved central (CNS) and peripheral (PNS) nervous systems. (ilo.org)
  • Symptoms and signs that present in demyelinating diseases are different for each condition. (wikipedia.org)
  • Mayoclinic.com notes that Parkinson's disease is primarily associated with motor nerve disruptions that cause symptoms such as tremors, loss of balance control and slowed movement. (livestrong.com)
  • Alzheimer's Disease Facts about Alzheimer's Disease, including the symptoms and stages. (vitals.com)
  • In HIV patients and other people with suppressed immune systems, however, the bacteria can cause brain abscess (tissue damage and the accumulation of pus) the symptoms of which vary depending on the location of the infection in the brain. (healthcommunities.com)
  • Peripheral neuropathic pain often includes symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity to normally painful stimuli. (mendeley.com)
  • Given the significance of the nervous system in human physiology, symptoms can involve other organ systems and result in motor dysfunction, sensory impairment, pain, etc. (wikipedia.org)
  • Libyan Journal of Infectious Diseases [The]. (bvsalud.org)
  • This development of an innovative method to enhance the immune system for the treatment of infectious diseases is similar to vaccinations without the side effects. (kalinka-store.com)
  • Thus, here is a real mechanism for an excellent and effective strategy against infectious diseases. (kalinka-store.com)
  • Diabetic Peripheral polyneuropathy (DPP) presents as a slowly progressive primary sensory deficit in length dependent fashion, to result in the classic stocking glove distribution. (bioportfolio.com)
  • centrencephalic system the neurons in the central core of the brainstem from the thalamus to the medulla oblongata, connecting the cerebral hemispheres . (thefreedictionary.com)
  • Thanks to flow of rhythm regulated afferent electric pulsation created during the procedure neurons of posterior horns substantia gelatinosa are stimulated, and their perception of nocigenic (pain) information coming from pathology center through thing non-myelinated nervous fibers with low velocity of pulses conducting is blocked. (denasms.com)
  • primarily will effect these peripheral, it will only effect these peripheral neurons. (coursera.org)
  • A demyelinating disease is any disease of the nervous system in which the myelin sheath of neurons is damaged. (wikipedia.org)
  • Demyelinating diseases are a group of disorders of the nervous system that involve loss of the myelin sheath that normally surrounds the neurons. (nature.com)
  • This is in direct contrast to its role in the central nervous system, where it triggers very different signals, exciting neurons and so promoting pain. (medicalxpress.com)
  • Substance P works in the peripheral system by modulating the action of certain proteins that control the ability of pain-sensing neurons to respond to 'painful' stimuli. (medicalxpress.com)
  • A neurodegenerative disease is a disease that causes damage to neurons. (wikipedia.org)
  • On the other hand, Parkinson's Disease results from damage of neurons in the Substantia Nigra, which is important to initiate motor behavior. (wikipedia.org)
  • Mud therapy may have therapeutic value in reducing inflammation and improving the immune status of patients with traumas of the peripheral nervous system. (greenmedinfo.com)
  • to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. (jcdr.net)
  • Methods: An international expert panel convened with the goal to provide guidance to clinicians who may encounter unrecognized patients with Fabry disease on how to diagnose these patients early using simple diagnostic tests. (uni-wuerzburg.de)
  • This is particularly important since management of pain in young patients with Fabry disease appears to be inadequate. (uni-wuerzburg.de)
  • Methods Patients were evaluated annually for 19 neuropsychiatric (NP) events including seven types of PNS disease. (ucl.ac.uk)
  • Since antibodies against peripheral nervous system (PNS) antigens may play a pathogenetic role in the mechanism of nerve damage in leprosy, sera from leprosy patients and contacts were investigated for anti-PNS antibodies by ELISA and immunoblot. (ilsl.br)
  • The main objective of this research is to optimize pain treatment with patients with occupation-conditioned diseases of the locomotor system (LMS) and the peripheral nervous system (PNS). (euroasia-science.ru)
  • The patients of this research were hospitalized in the Department of Occupational Diseases, UMHAT "Dr. Georgi Stranski"- Pleven, during the period 2014-2016. (euroasia-science.ru)
  • The aim of the study is to optimize the treatment of pain in patients with work related diseases of the bones-joints and peripheral nervous system. (euroasia-science.ru)
  • Those who have been diagnosed with complex diseases, such patients also receive high-end diagnostic examination and rehabilitation measures. (placidway.com)
  • We conducted a phase 3, open-label trial involving patients with HER2-positive early breast cancer who were found to have residual invasive disease in the breast or axilla at surgery after receiving neoadjuvant therapy containing a taxane (with or without anthracycline) and trastuzumab. (nih.gov)
  • The estimated percentage of patients who were free of invasive disease at 3 years was 88.3% in the T-DM1 group and 77.0% in the trastuzumab group. (nih.gov)
  • Distant recurrence as the first invasive-disease event occurred in 10.5% of patients in the T-DM1 group and 15.9% of those in the trastuzumab group. (nih.gov)
  • Among patients with HER2-positive early breast cancer who had residual invasive disease after completion of neoadjuvant therapy, the risk of recurrence of invasive breast cancer or death was 50% lower with adjuvant T-DM1 than with trastuzumab alone. (nih.gov)
  • There is recent evidence to indicate that patients with impaired glucose tolerance ( IGT) on OGTT, the prediabetic stage, have three times the prevalence of distal peripheral polyneuropathy than age matched controls. (bioportfolio.com)
  • In patients with such neurologic disease, especially if sudden in onset, a search for a circulatory basis in lesions of the aorta or its branches may be rewarding and crucial. (biomedsearch.com)
  • Cook treats patients with diseases affecting the central or peripheral nervous system. (courant.com)
  • Tai chi chuan exercise improves fasting blood glucose and peripheral nerve conduction velocities in type 2 diabetic patients. (greenmedinfo.com)
  • Determine the change in peripheral nerve function in cancer patients during and after treatment with chemotherapy or biologic therapy. (knowcancer.com)
  • Patients undergo a 1-hour peripheral nerve function assessment, including hearing, vibratory sensation, and blood pressure testing, at baseline and then at 4, 8, and 12 weeks during treatment with chemotherapy or biologic therapy. (knowcancer.com)
  • The most common central nervous system disorder in HIV patients is the infection toxoplasmosis, followed by HIV-related brain cancer. (healthcommunities.com)
  • Cerebral toxoplasmosis, also known simply as toxoplasmosis, is the most common central nervous system infection in HIV patients. (healthcommunities.com)
  • Central nervous system lymphoma is the second most common nervous system abnormality in HIV patients. (healthcommunities.com)
  • TPD significantly attenuated TACE-mediated disease models of sepsis, rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), and reduced TNFa in synovial fluids from RA patients. (weizmann.ac.il)
  • Classification of cases of yellow fever vaccine-associated neurologic disease with Centers for Disease Control and Prevention criteria, São Paulo, Brazil, 2017-2018. (cdc.gov)
  • YEL-AND, yellow fever vaccine-associated neurologic disease. (cdc.gov)
  • Most of the large envelope-bearing viruses that figured prominently in older series of ADEM, of which measles was a particularly virulent example, no longer figure importantly in the etiology of ADEM because these diseases are prevented by vaccination. (medscape.com)
  • Targeting central pathways implicated in complex disease mechanisms (neurodegeneration, consequences of traumatic injury, chronic pain). (frontiersin.org)
  • Peripheral pain can be chronic and/or occur as provoked attacks of excruciating pain. (uni-wuerzburg.de)
  • Their wellness and therapeutic programs not just treat severe chronic diseases, but also provide rejuvenation and prevention of aging. (placidway.com)
  • Individuals with POEMS syndrome experience chronic, progressive disease affecting the peripheral nervous system. (rarediseases.org)
  • whereas, MS is typically a chronic relapsing and remitting disease of young adults. (medscape.com)
  • This case appears unique for the type of histologically documented cardiac and neurological parenchymal involvement, and at the same time, exemplifies the subtle and pernicious course of the disease. (springer.com)
  • It is important for to know how to overcome your peripheral nervous system disease since it is one of the disease which affects many people and you need to share with people you trust. (howtohint.com)
  • NHS Choices: Neurofibromatosis Provides information on this genetic disorder that affects the nervous system and the skin. (inter.rs)
  • Which autpimmune disease affects the nervous system? (healthtap.com)
  • POEMS syndrome affects multiple organ systems of the body. (rarediseases.org)
  • While most nervous system diseases affect either CNS or PNS, this disease affects both, but it is the changes in the peripheral nervous system that lead to death. (wikipedia.org)
  • These findings provide new insights on the molecular mechanisms of Krabbe disease, representing a starting point for future functional experiments to study the molecular pathogenesis of Krabbe disease. (nih.gov)
  • [12] Therefore, the role of the human-specific prolonged period of cortical myelination is an important evolutionary consideration in the pathogenesis of demyelinating disease. (wikipedia.org)
  • The major effect of GALC deficiency is the accumulation of psychosine in the nervous system and widespread degeneration of oligodendrocytes and Schwann cells, causing rapid demyelination. (nih.gov)
  • More than 400 protein groups exhibited differences in expression and included proteins involved in pathways that can be linked to Krabbe disease, such as inflammatory and defense response, lysosomal proteins accumulation, demyelination, reduced nervous system development and cell adhesion. (nih.gov)
  • Neurodegneration is different in each disease, for example, MS is a result of a degenerative process called demyelination. (wikipedia.org)
  • Which autoimmune diseases affect the nervous system? (healthtap.com)
  • Because they can rapidly produce large amounts of regulatory cytokines, a reduction of NK T cells may lead to the development of certain autoimmune diseases. (jimmunol.org)
  • Although a requirement of NK T cells for a Th2 immune response is not absolute ( 13 , 14 ), accumulating evidence supports the role of NK T cells in the regulation of autoimmune diseases ( 15 , 16 , 17 , 18 , 19 , 20 ). (jimmunol.org)
  • It has recently been reported that NK T cells may be numerically or functionally altered in certain autoimmune diseases. (jimmunol.org)
  • A decreased number of NK T cells was demonstrated in human systemic sclerosis ( 15 ), insulin-dependent diabetes mellitus ( 16 ), and spontaneous autoimmune diseases in rodents ( 17 , 18 , 19 ). (jimmunol.org)
  • Moreover, none of the studies have addressed whether NK T cells may participate in the local regulation of autoimmune diseases. (jimmunol.org)
  • The subject is 58 people hospitalized in the Department of Occupational Diseases, University Hospital - Pleven in 2014-2016. (euroasia-science.ru)
  • All musculoskeletal system and peripheral nervous system diseases and traumatic injuries in acute period are characterized by acute pain, edema, soft tissues hemorrhage, extravasations and infusions into joint cavity, inflammatory reaction and dysfunction. (denasms.com)
  • If you cut a, an axon in the peripheral nervous system, it can repair itself. (coursera.org)
  • Peripheral Nerve Diffusion Tensor Imaging: Assessment of Axon and Myelin Sheath Integrity. (uni-heidelberg.de)
  • Unlike other primates, humans exhibit a unique pattern of postpubertal myelination, which may contribute to the development of psychiatric disorders and neurodegenerative diseases that present in early adulthood and beyond. (wikipedia.org)
  • It has been previously speculated that injury-induced degeneration ( Wallerian degeneration) shares some molecular features with `dying back' neurodegenerative diseases. (weizmann.ac.il)
  • In the peripheral nervous system, B. burgdorferi infection is associated with mononeuritis multiplex and polyradiculoneuritis. (medconditions.net)
  • It invades and impairs the body's immune system parts and processes of the body that fight disease and infection. (healthcommunities.com)
  • Features an abstract that discuss how toxic and infection impedes the development of the nervous system. (botw.org)
  • Polyneuropathies are highly prevalent and represent the most common neurological sequelae in many systemic disorders such as diabetes, alcoholism, HIV or hepatitis infection, leukemia and other oncological diseases. (uni-heidelberg.de)
  • For example, meningitis is a common infection of the central nervous system, where bacterial or viral infections cause an inflammation of the meninges. (wikipedia.org)
  • A case-control study of the prevalence of neurological diseases in inflammatory bowel disease (IBD). (uams.edu)
  • Peripheral nerve disorders encompass a spectrum of heterogeneous disorders of inflammatory, toxic, degenerative or metabolic origin. (uni-heidelberg.de)
  • Acquired immune system cells called T-cells are known to be present at the site of lesions. (wikipedia.org)
  • Peripheral nerve diseases are among the most prevalent disorders of the nervous system. (nih.gov)
  • Amyloidosis , is a rare but severe complication and can affect the nervous system. (healthtap.com)
  • Diabetes can affect the nervous system but the cause of diabetes is not the nervous system. (healthtap.com)
  • Does Lyme disease affect the nervous system? (healthtap.com)
  • Pathogens like fungi, bacteria, and viruses can affect the nervous system. (wikipedia.org)
  • In the last two decades, gene therapy has made considerable achievements, particularly in the field of neurological diseases. (frontiersin.org)
  • Examples of neurodegenerative disease include Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis. (wikipedia.org)
  • For example, the collection of glands in the endocrine system can be thought of as a system, each endocrine gland could be viewed as a system, or even specific cells of a single gland could be studied as a system. (thefreedictionary.com)
  • It is also possible to think of the human body as a living system and the endocrine system as a subsystem. (thefreedictionary.com)
  • Individuals with POEMS syndrome may exhibit various abnormalities affecting the endocrine system (i.e., the system of glands that secrete hormones into the blood system). (rarediseases.org)
  • This concerned genetic (particularly lysosomal diseases) but also complex multifactorial disorders (Parkinson and Alzheimer's diseases). (frontiersin.org)
  • Are most nervous system diseases genetic? (healthtap.com)
  • Homology closed out the year by nominating development candidates for two additional programs focused on pediatric rare genetic diseases, both of which have entered into IND-enabling studies. (yahoo.com)
  • Some nervous system diseases are due to genetic mutations. (wikipedia.org)
  • Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. (mendeley.com)
  • Neuropathic pain is a common symptom in many diseases of the peripheral nervous system. (mendeley.com)
  • Conclusion: Our findings demonstrate the absence of significant functional, structural, or compositional abnormalities in the peripheral nervous system of the murine model for Sandhoff disease, but do show the potential value of integrating multiple techniques to evaluate myelin structure and function in nervous system disorders. (harvard.edu)
  • Any of various diseases or abnormalities of the nervous system, especially of the peripheral nervous system. (thefreedictionary.com)
  • For example, Anencephaly (or spina bifida) causes abnormalities in the nervous system due to neural tube defects. (wikipedia.org)
  • The immediate effect of injury of a peripheral nerve is a variable degree of dysfunction, depending on the severity of the injury. (merckvetmanual.com)
  • Diseases that affect this area include Parkinson's disease and Huntington's disease . (medicalnewstoday.com)
  • Parkinson's disease is a nervous system disorder whose origins remain unclear. (livestrong.com)
  • In Parkinson's disease, the brain produces inadequate amounts of dopamine, and protein masses called Lewy bodies form in the brain. (livestrong.com)
  • The efficacy of gene therapy tools such as viral vectors, serotypes and therapeutic cassettes, the delivery systems manufacturing and quality control. (frontiersin.org)
  • find that regeneration of CNS myelin requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state, revealing new therapeutic targets for neurodegenerative disease. (nature.com)
  • This report is representative of the neurological and cardiac changes described in the literature for IgG4-related disease, which may be correlated or not with the renal form and highlights the need, in some cases, of targeted therapeutic approaches. (springer.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Saving Lives, Protecting People Centers for Disease Control and Prevention. (cdc.gov)
  • Krabbe disease is a rare, childhood lysosomal storage disorder caused by a deficiency of galactosylceramide beta-galactosidase (GALC). (nih.gov)
  • The molecular mechanisms of Krabbe disease are not yet fully elucidated and a definite cure is still missing. (nih.gov)
  • Here we report the first in-depth characterization of the proteome of the Twitcher mouse, a spontaneous mouse model of Krabbe disease, to investigate the proteome changes in the Central and Peripheral Nervous System. (nih.gov)
  • Are you referring to autoimmune types of connective tissue diseases, such as rheumatoid or psoriatic arthritis ? (healthtap.com)
  • Can untreated rheumatoid arthritis cause nervous system damage or problems with the nervous system? (healthtap.com)
  • The second cranial nerve is not a true peripheral nerve but a tract of the diencephalon . (wikipedia.org)
  • A general term indicating inflammation of a peripheral or cranial nerve. (curehunter.com)
  • The sympathetic nervous system regulates blood flow and perspiration. (livestrong.com)
  • This JAX course will focus on the use of the innovative tools and methods, specifically in the laboratory mouse, for answering questions of neuron and circuit function and disease mechanisms during neurodegeneration. (jax.org)
  • A natural substance known to activate pain in the central nervous system has been found to have the opposite effect in other parts of the body, potentially paving the way to new methods of pain control. (medicalxpress.com)
  • Background: Sandhoff disease is an inherited lysosomal storage disease caused by a mutation in the gene for the β-subunit (Hexb gene) of β-hexosaminidase A (αβ) and B (ββ). (harvard.edu)
  • Background: Fabry disease is an inherited metabolic disorder characterized by progressive lysosomal accumulation of lipids in a variety of cell types, including neural cells. (uni-wuerzburg.de)
  • The nervous system is the body's most well-organized and complex structural and functional system. (howtohint.com)
  • But we've discovered a paradox - that in the peripheral nervous system it acts as one of the body's natural painkillers and actually suppresses pain. (medicalxpress.com)
  • Drugs like morphine hijack the body's natural painkilling mechanisms, such as those used by endorphins, but because they act within the central nervous system, they can affect other brain cells that use similar pathways, leading to side effects such as addiction or sleepiness," says Professor Gamper. (medicalxpress.com)