The fibrous CONNECTIVE TISSUE surrounding the TOOTH ROOT, separating it from and attaching it to the alveolar bone (ALVEOLAR PROCESS).
Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile.
The bonelike rigid connective tissue covering the root of a tooth from the cementoenamel junction to the apex and lining the apex of the root canal, also assisting in tooth support by serving as attachment structures for the periodontal ligament. (Jablonski, Dictionary of Dentistry, 1992)
Fibrous cords of CONNECTIVE TISSUE that attach bones to each other and hold together the many types of joints in the body. Articular ligaments are strong, elastic, and allow movement in only specific directions, depending on the individual joint.
Orthodontic techniques used to correct the malposition of a single tooth.
The structures surrounding and supporting the tooth. Periodontium includes the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
The thickest and spongiest part of the maxilla and mandible hollowed out into deep cavities for the teeth.
The emergence of a tooth from within its follicle in the ALVEOLAR PROCESS of the MAXILLA or MANDIBLE into the ORAL CAVITY. (Boucher's Clinical Dental Terminology, 4th ed)
The most posterior teeth on either side of the jaw, totaling eight in the deciduous dentition (2 on each side, upper and lower), and usually 12 in the permanent dentition (three on each side, upper and lower). They are grinding teeth, having large crowns and broad chewing surfaces. (Jablonski, Dictionary of Dentistry, 1992, p821)
Two extensive fibrous bands running the length of the vertebral column. The anterior longitudinal ligament (ligamentum longitudinale anterius; lacertus medius) interconnects the anterior surfaces of the vertebral bodies; the posterior longitudinal ligament (ligamentum longitudinale posterius) interconnects the posterior surfaces. The commonest clinical consideration is OSSIFICATION OF POSTERIOR LONGITUDINAL LIGAMENT. (From Stedman, 25th ed)
The part of a tooth from the neck to the apex, embedded in the alveolar process and covered with cementum. A root may be single or divided into several branches, usually identified by their relative position, e.g., lingual root or buccal root. Single-rooted teeth include mandibular first and second premolars and the maxillary second premolar teeth. The maxillary first premolar has two roots in most cases. Maxillary molars have three roots. (Jablonski, Dictionary of Dentistry, 1992, p690)
A genus of PICORNAVIRIDAE causing infectious hepatitis naturally in humans and experimentally in other primates. It is transmitted through fecal contamination of food or water. HEPATITIS A VIRUS is the type species.
Horizontal and, to a lesser degree, axial movement of a tooth in response to normal forces, as in occlusion. It refers also to the movability of a tooth resulting from loss of all or a portion of its attachment and supportive apparatus, as seen in periodontitis, occlusal trauma, and periodontosis. (From Jablonski, Dictionary of Dentistry, 1992, p507 & Boucher's Clinical Dental Terminology, 4th ed, p313)
A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation.
One of a set of bone-like structures in the mouth used for biting and chewing.
Resorption in which cementum or dentin is lost from the root of a tooth owing to cementoclastic or osteoclastic activity in conditions such as trauma of occlusion or neoplasms. (Dorland, 27th ed)
A richly vascularized and innervated connective tissue of mesodermal origin, contained in the central cavity of a tooth and delimited by the dentin, and having formative, nutritive, sensory, and protective functions. (Jablonski, Dictionary of Dentistry, 1992)
Dense fibrous layer formed from mesodermal tissue that surrounds the epithelial enamel organ. The cells eventually migrate to the external surface of the newly formed root dentin and give rise to the cementoblasts that deposit cementum on the developing root, fibroblasts of the developing periodontal ligament, and osteoblasts of the developing alveolar bone.
The formation of DENTAL CEMENTUM, a bone-like material that covers the root of the tooth.
A band of fibrous tissue that attaches the apex of the PATELLA to the lower part of the tubercle of the TIBIA. The ligament is actually the caudal continuation of the common tendon of the QUADRICEPS FEMORIS. The patella is embedded in that tendon. As such, the patellar ligament can be thought of as connecting the quadriceps femoris tendon to the tibia, and therefore it is sometimes called the patellar tendon.
A hollow part of the alveolar process of the MAXILLA or MANDIBLE where each tooth fits and is attached via the periodontal ligament.
Rebuilding of the ANTERIOR CRUCIATE LIGAMENT to restore functional stability of the knee. AUTOGRAFTING or ALLOGRAFTING of tissues is often used.
The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.
A calcification of the posterior longitudinal ligament of the spinal column, usually at the level of the cervical spine. It is often associated with anterior ankylosing hyperostosis.
A wedge-shaped collar of epithelial cells which form the attachment of the gingiva to the tooth surface at the base of the gingival crevice.
Oral tissue surrounding and attached to TEETH.
A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis.
A tooth from which the dental pulp has been removed or is necrotic. (Boucher, Clinical Dental Terminology, 4th ed)
The description and measurement of the various factors that produce physical stress upon dental restorations, prostheses, or appliances, materials associated with them, or the natural oral structures.
The tip or terminal end of the root of a tooth. (Jablonski, Dictionary of Dentistry, 1992, p62)
A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Techniques for enhancing and directing cell growth to repopulate specific parts of the PERIODONTIUM that have been damaged by PERIODONTAL DISEASES; TOOTH DISEASES; or TRAUMA, or to correct TOOTH ABNORMALITIES. Repopulation and repair is achieved by guiding the progenitor cells to reproduce in the desired location by blocking contact with surrounding tissue by use of membranes composed of synthetic or natural material that may include growth inducing factors as well.
Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
A fibromuscular band that attaches to the UTERUS and then passes along the BROAD LIGAMENT, out through the INGUINAL RING, and into the labium majus.
A computer based method of simulating or analyzing the behavior of structures or components.
The constricted part of the tooth at the junction of the crown and root or roots. It is often referred to as the cementoenamel junction (CEJ), the line at which the cementum covering the root of a tooth and the enamel of the tooth meet. (Jablonski, Dictionary of Dentistry, 1992, p530, p433)
One of a pair of irregularly shaped bones that form the upper jaw. A maxillary bone provides tooth sockets for the superior teeth, forms part of the ORBIT, and contains the MAXILLARY SINUS.
The upper part of the tooth, which joins the lower part of the tooth (TOOTH ROOT) at the cervix (TOOTH CERVIX) at a line called the cementoenamel junction. The entire surface of the crown is covered with enamel which is thicker at the extremity and becomes progressively thinner toward the cervix. (From Jablonski, Dictionary of Dentistry, 1992, p216)
The process of bone formation. Histogenesis of bone including ossification.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
A highly potent and specific histamine H2 receptor agonist. It has been used diagnostically as a gastric secretion indicator.
Lack of stability of a joint or joint prosthesis. Factors involved are intra-articular disease and integrity of extra-articular structures such as joint capsule, ligaments, and muscles.
Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
The upkeep of property or equipment.
One of the eight permanent teeth, two on either side in each jaw, between the canines (CUSPID) and the molars (MOLAR), serving for grinding and crushing food. The upper have two cusps (bicuspid) but the lower have one to three. (Jablonski, Dictionary of Dentistry, 1992, p822)
A spiral thickening of the fibrous lining of the cochlear wall. Spiral ligament secures the membranous COCHLEAR DUCT to the bony spiral canal of the COCHLEA. Its spiral ligament fibrocytes function in conjunction with the STRIA VASCULARIS to mediate cochlear ion homeostasis.
The physiological renewal, repair, or replacement of tissue.
Forcible or traumatic tear or break of an organ or other soft part of the body.
A synthetic analog of LYPRESSIN with a PHENYLALANINE substitution at residue 2. Felypressin is a vasoconstrictor with reduced antidiuretic activity.
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.
The force applied by the masticatory muscles in dental occlusion.
A clear, homogenous, structureless, eosinophilic substance occurring in pathological degeneration of tissues.
Remaining tissue from normal DERMIS tissue after the cells are removed.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
Traumatic or other damage to teeth including fractures (TOOTH FRACTURES) or displacements (TOOTH LUXATION).
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
Fibrous bands or cords of CONNECTIVE TISSUE at the ends of SKELETAL MUSCLE FIBERS that serve to attach the MUSCLES to bones and other structures.
Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
The process whereby calcium salts are deposited in the dental enamel. The process is normal in the development of bones and teeth. (Boucher's Clinical Dental Terminology, 4th ed, p43)
Mesodermal tissue enclosed in the invaginated portion of the epithelial enamel organ and giving rise to the dentin and pulp.
Wires of various dimensions and grades made of stainless steel or precious metal. They are used in orthodontic treatment.
The properties and processes of materials that affect their behavior under force.
A range of methods used to reduce pain and anxiety during dental procedures.
A treatment modality in endodontics concerned with the therapy of diseases of the dental pulp. For preparatory procedures, ROOT CANAL PREPARATION is available.
The property of nonisotropic media, such as crystals, whereby a single incident beam of light traverses the medium as two beams, each plane-polarized, the planes being at right angles to each other. (Cline et al., Dictionary of Visual Science, 4th ed)
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Break or rupture of a tooth or tooth root.
A phosphoprotein phosphatase that is specific for MYOSIN LIGHT CHAINS. It is composed of three subunits, which include a catalytic subunit, a myosin binding subunit, and a third subunit of unknown function.
The generic term for salts derived from silica or the silicic acids. They contain silicon, oxygen, and one or more metals, and may contain hydrogen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th Ed)
The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected. (From Jablonski, Dictionary of Dentistry, 1992)
A highly glycosylated and sulfated phosphoprotein that is found almost exclusively in mineralized connective tissues. It is an extracellular matrix protein that binds to hydroxyapatite through polyglutamic acid sequences and mediates cell attachment through an RGD sequence.
The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001)
Devices used for influencing tooth position. Orthodontic appliances may be classified as fixed or removable, active or retaining, and intraoral or extraoral. (Boucher's Clinical Dental Terminology, 4th ed, p19)
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Materials placed inside a root canal for the purpose of obturating or sealing it. The materials may be gutta-percha, silver cones, paste mixtures, or other substances. (Dorland, 28th ed, p631 & Boucher's Clinical Dental Terminology, 4th ed, p187)
Inorganic compounds that contain calcium as an integral part of the molecule.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
The teeth of the first dentition, which are shed and replaced by the permanent teeth.
Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.
Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.

Morphological changes in periodontal mechanoreceptors of mouse maxillary incisors after the experimental induction of anterior crossbite: a light and electron microscopic observation using immunohistochemistry for PGP 9.5. (1/391)

Ruffini nerve endings (mechanoreceptors) in the periodontal ligament (PDL) of mouse incisors were examined to elucidate whether experimentally-induced crossbites cause any changes or abnormalities in their morphology and distribution. Anterior guiding planes were attached to the mandibular incisors of 3-week-old C3H/HeSlc mice. At 3 days and 1, 2, 4, 6, and 8 weeks post-attachment of the appliance, the mice were sacrificed by perfusion fixation. Frozen sagittal cryostat sections of the decalcified maxillary incisors were processed for immunohistochemistry of protein gene product 9.5, followed by histochemical determination of tartrate-resistant acid phosphatase activity to reveal sites of alveolar bone resorption. Despite the absence of bone resorption within the lingual PDL of control mice, distinct resorption sites were seen in the respective regions of the experimental animals. Unlike the controls, many Ruffini endings showing vague and swollen contours, with unusually long and pedunculated micro-projections were observed in the affected lingual PDL of the incisors in the experimental animals with short-term anterior crossbite induction. Club-shaped nerve terminations with few, if any, micro-projections were observed in the lingual PDL of experimental animals with long-term induction, as well as in aged control mouse incisors. Differences in the distribution of Ruffini endings were also observed. These results indicate that changing the direction of the force applied to the PDL results in rapid and prolonged changes in the morphology of Ruffini-like mechanoreceptors.  (+info)

Histochemical studies of glycosaminoglycans in developing periodontal ligaments of ICR mice. (2/391)

Although the periodontal ligament (PL) contains an abundance of glycosaminoglycans (GAGs), there are only a few histochemical studies describing GAGs in the developing PL. In the present study, the relationship between the formation of principal fibers and the molecular species of GAGs in the developing PL was examined by light microscopic histochemistry. Jcl:ICR mice were killed on day 0 to day 28 after birth. Paraffin-embedded tissue sections were routinely made and stained with hematoxylin-eosin (H&E), Azan, or the sensitized high iron diamine (S-HID) procedure combined with enzyme digestions. Before tooth eruption, thin threads of collagen fibers in the PL assembled and constructed principal fibers, which projected from both the side of the alveolar bone and the root of the tooth. After tooth eruption, the principal fibers from both sides were tightly entangled. In the developing PL, the molecular species of GAGs was mainly dermatan sulfate. Moreover, the relative amount of dermatan sulfate increased together with the maturation of the principal fibers, while the principal fibers adjacent to the alveolar bone and cementum contained chondroitin sulfate. These results suggest that dermatan sulfate contributes to collagen fiber assembly in the PL and that chondroitin sulfate relates to PL adhesion to the alveolar bone and to the cementum of the root.  (+info)

Postnatal expression of calretinin-immunoreactivity in periodontal Ruffini endings in the rat incisor: a comparison with protein gene product 9.5 (PGP 9.5)-immunoreactivity. (3/391)

The postnatal expression of immunoreactivity for calretinin, one of the calcium binding proteins, and for protein gene product 9.5 (PGP 9.5), a general neuronal marker, was investigated in mechanoreceptive Ruffini endings in the periodontal ligament of the rat incisor. Age-related changes in the expression of these two proteins in periodontal nerves were further quantified with a computerized image analysis. At 1 day after birth, a few PGP 9.5-immunoreactive nerve fibers and a still smaller number of calretinin-positive fibers were found in the periodontal ligament: they were thin and beaded in appearance and no specialized nerve terminals were recognized. Tree-like terminals, reminiscent of immature Ruffini endings, were recognizable in 4-day-old rats by PGP 9.5-immunohistochemistry, while calretinin-immunostaining failed to reveal these specialized endings. At postnatal 7-11 days when PGP 9.5-immunostaining could demonstrate typical Ruffini endings, calretinin-immunopositive nerve fibers merely tapered off without forming the Ruffini type endings. A small number of Ruffini endings showing calretinin-immunoreactivity began to occur in the periodontal ligament at 24-26 days after birth when the occlusion of the first molars had been established. At the functional occlusion stage (60-80 days after birth), the Ruffini endings showing calretinin-immunoreactivity drastically increased in number and density, but less so than those positive for PGP 9.5-immunoreaction. The delayed expression of calretinin suggests that the function of the periodontal Ruffini endings is established after the completion of terminal formation because Ca2+, which binds to calcium binding proteins including calretinin with high affinity, plays an important role in mechano-electric transduction.  (+info)

Alteration in the expression level of calbindin D28k in the periodontal ligament of the rat molar during experimental tooth movement. (4/391)

The present immunohistochemical study was designed to investigate changes in the distribution and expression level of calbindin D28k in the periodontal ligament during experimental tooth movement in the rat molar to clarify the physiological role of this protein in the ligament. In normal animals, calbindin D28k-like immunoreactivity appeared sparsely in spindle-shaped cells in the alveolar half of the periodontal ligament. Electron microscopic observations showed that these immunoreactive cells were characterized by well-developed rough-surfaced endoplasmic reticulum and phagosomes--which often contained collagen fibers--suggesting that these cells could be categorized as periodontal fibroblasts. Twelve hours following the onset of the experimental tooth movement, cells positive for calbindin D28k increased in number in the periodontal ligament, especially in the alveolar half of the pressured side. Immunoelectron microscopy showed that the calbindin D28k-immunopositive cells had morphological features similar to those of fibroblasts in the normal ligament, and that these cells occasionally made contact with immunonegative macrophage-like cells. Immunopositive cells gradually decreased in number, and the distribution of the cells and intensity of the immunoreactivity returned to normal levels by 14 days following the induction of the experimental tooth movement. The present results suggest that calbindin D28k plays an important role in the homeostasis and cyto-protection of fibroblasts in the periodontal ligament at the initial phase of experimental tooth movement.  (+info)

Mutations in the heparin binding domain of fibronectin in cooperation with the V region induce decreases in pp125(FAK) levels plus proteoglycan-mediated apoptosis via caspases. (5/391)

Intact fibronectin (FN) protects cells from apoptosis. When FN is fragmented, specific domains induce proteinase expression in fibroblasts. However, it is not known whether specific domains of FN can also regulate apoptosis. We exposed fibroblasts to four recombinant FN fragments and then assayed for apoptosis using criteria of cellular shape change, condensed nuclear morphology, and DNA fragmentation. The fragments extended from the RGD-containing repeat III10 to III15; they included (V(+)) or excluded (V(-)) the alternatively spliced V region and contained either a mutated (H(-)) or an unmutated (H(+)) heparin binding domain. Only the V(+)H(-) fragment triggered decreases in pp125(FAK) levels and apoptosis, which was rescued by intact FN and inhibitors of caspase-1 and caspase-3. This apoptotic mechanism was mediated by a chondroitin sulfate proteoglycan, since treating cells with chondroitin sulfate or chondroitinase reversed the apoptotic cell shape changes. The alpha4 integrin receptor may also be involved, since using a blocking antibody to alpha4 alone induced apoptotic cell shape changes, whereas co-treatment with this antibody plus V(+)H(+) reversed these effects. These results demonstrate that the V and heparin binding domains of FN modulate pp125(FAK) levels and regulate apoptosis through a chondroitin sulfate proteoglycan- and possibly alpha4 integrin-mediated pathway, which triggers a caspase cascade.  (+info)

Blood vessel response to pan-endothelium (RECA-1) antibody in normal and tooth loaded rat periodontal ligament. (6/391)

Immunolabelling of the normal rat molar periodontal ligament (PDL) with RECA-1 antibody, an endothelial cell surface marker, demonstrated the endothelium in the different categories of blood vessels. The intensity of immunolabelling was similar for venous capillaries (VC), post-capillary-sized venules (PCV), and collecting venules (CV). Arterial capillaries (AC) and terminal arterioles (TA) showed a different response, both having a high intensity of endothelium and smooth muscle cell labelling, whether they were located in the PDL or alveolar bone. An experimental, continuous loading of approximately 100 g was applied unilaterally to the mandibular molars for 10 minutes. In the PDL apical compression zone this load resulted in a loss of RECA-1 immunolabelling of the VC, PCV, and CV. Adjacent to the alveolar crest, where shear and tension loads were judged to have occurred, there was enhanced immunoreactivity of VC, PCV, and CV. In the loaded PDL, the AC and TA, irrespective of their location in the ligament or bone, showed strong immunofluorescence of their endothelium and the enveloping smooth muscle layer. Vessel and PDL immunofluorescence were analysed with standardized grey scale densitometry, and the data subjected to ANOVA. Comparison between individual vessel means showed significant differences (P < 0.05). Control teeth showed no immunostaining difference between the coronal and apical region vessels, whereas in the loaded teeth the overall cervical vessel endothelium had a significantly higher value than the apical vessel endothelium (P < 0.001). These findings demonstrate that the endothelium of this microvascular bed can undergo significant immunoreactivity changes when exposed to short-term, continuous, tooth loading.  (+info)

Increase of CD26/dipeptidyl peptidase IV expression on human gingival fibroblasts upon stimulation with cytokines and bacterial components. (7/391)

CD26/dipeptidyl peptidase IV (DPPIV) is a cell surface ectoenzyme which participates in immune and inflammatory reactions. We found that CD26 was only partially expressed on human fibroblasts from periodontal tissues, whereas fibroblasts from lung and skin expressed CD26 constitutively as revealed by flow cytometry. We examined the possible upregulation of CD26 expression on human gingival fibroblasts in response to various stimulants. Interleukin-1alpha (IL-1alpha); tumor necrosis factor alpha; gamma interferon; lipopolysaccharide from Porphyromonas gingivalis, Prevotella intermedia, and Escherichia coli; and Prevotella glycoprotein augmented CD26 expression on gingival fibroblasts. Among the stimulants, IL-1alpha exhibited the most potent activity. Enzymatic activity of CD26 induced by IL-1alpha on fibroblasts was determined colorimetrically in terms of Gly-Pro hydrolysis of a synthetic chromogenic substrate, Gly-Pro p-nitroanilide. Among various inhibitors tested, diprotin A and phenylmethylsulfonyl fluoride inhibited the enzymatic activity, suggesting that the enzyme induced by IL-1alpha was DPPIV. The upregulation of CD26 mRNA expression upon stimulation with IL-1alpha was also revealed by a quantitative reverse transcription-PCR assay. In the kinetic experiment, 48 h and several days were required for maximum CD26 mRNA accumulation and CD26 molecule expression on the cell surface, respectively. The addition of cycloheximide at 2 h before IL-1alpha stimulation almost completely inhibited the accumulation of CD26 mRNA. These results suggested that induction of CD26 on human gingival fibroblasts is regulated at the transcriptional level and is also dependent on a de novo-synthesized protein factor(s).  (+info)

Determination of the centre of resistance in an upper human canine and idealized tooth model. (8/391)

The purpose of this investigation was to analyse the influence of geometric and material parameters of a human canine on initial tooth mobility, and the stress and strain profiles in the periodontal ligament. While the material parameters of tooth and bony structures are known within an uncertain limit of approximately a factor of 10, values reported for the elasticity parameters of the periodontal ligament differ significantly. In the course of this study, bilinear behaviour was assumed for the mechanical property of the periodontium. The finite element model of an elliptical paraboloid was created as an approximation to the geometry of a human canine to reduce calculation time and to determine influences of the geometry on numerical results. The results were compared with those obtained for a realistic human canine model. The root length of both models was 19.5 mm. By calculating pure rotational and pure tipping movements, the centre of resistance (CR) was determined for both models. They were located on the long axis of the tooth approximately 7.2 mm below the alveolar crest for the idealized model and 8.2 mm for the canine model. Thus, the centre of resistance of a human canine seems to be located around two-fifths of the root length from the alveolar margin. Using these results, uncontrolled tipping (1 N of mesializing force and 5 Nmm of derotating momentum), as well as pure translation (additionally about 10 Nmm of uprighting momentum) were calculated. Comparing the idealized and the realistic models, the uncontrolled tipping was described by the parabolic-shaped model within an accuracy limit of 10 per cent as compared with the canine model, whereas the results for bodily movement differed significantly showing that it is very difficult to achieve a pure translation with the realistic canine model.  (+info)

TY - JOUR. T1 - Retinoic acid is a potential negative regulator for differentiation of human periodontal ligament cells. AU - Shibuya, Natsuko. AU - Nemoto, Eiji. AU - Kanaya, Sousuke. AU - Kunii, Ryotaro. AU - Shimauchi, Hidetoshi. PY - 2005/9/1. Y1 - 2005/9/1. N2 - Retinoic acid (RA) exerts a wide variety of effects on development, cellular differentiation and homeostasis in various tissues. However, little is known about the effects of RA on the differentiation of periodontal ligament cells. In this study, we investigated whether RA can affect the dexamethasone-induced differentiation of periodontal ligament cells. Human periodontal ligament cells were differentiated via culturing in the presence of dexamethasone, ascorbic acid, and β-glycerophosphate for mineralized nodule formation, as characterized by von Kossa staining. Continuous treatment with all-trans-RA inhibited mineralization in a dose-dependent manner, with complete inhibition over 1 μM RA. Other RA analogs, 9-cis-RA and ...
Background and Objective: Molecular gene markers, which can distinguish human bone marrow mesenchymal stem cells from human fibroblasts, have recently been reported. Messenger RNA levels of tissue factor pathway inhibitor-2, major histocompatibility complex-DR-α, major histocompatibility complex-DR-β, and neuroserpin are higher in human bone marrow mesenchymal stem cells than in human fibroblasts. However, human bone marrow mesenchymal stem cells express less apolipoprotein D mRNA than human fibroblasts. Periodontal ligament cells are a heterogeneous cell population including fibroblasts, mesenchymal stem cells, and progenitor cells of osteoblasts or cementoblasts. The use of molecular markers that distinguish human bone marrow mesenchymal stem cells from human fibroblasts may provide insight into the characteristics of human periodontal ligament cells. In this study, we compared the molecular markers of human periodontal ligament cells with those of human bone marrow mesenchymal stem cells ...
BACKGROUND AND OBJECTIVE: The antimicrobial peptide LL-37 is expressed in periodontal tissue, and variations in LL-37 levels have been associated with periodontal disease. The effects of LL-37 on periodontal ligament cell function have not been described before. Here, we assess anti-inflammatory properties of LL-37 and investigate the effects of LL-37 on cell differentiation, cell proliferation and apoptosis in human periodontal ligament cells. MATERIAL AND METHODS: Periodontal ligament cells were obtained from teeth extracted for orthodontic reasons. Cytokine (interleukin-6) and chemokine (monocyte chemoattractant protein-1) expression was determined by quantitative PCR, cell differentiation by alkaline phosphatase activity, cell proliferation by counting cells in a Bürker chamber, DNA synthesis by incorporation of radiolabeled thymidine and apoptosis by cell morphology and activated caspase 3 quantities. RESULTS: Treatment with 0.1 and 1 μm of LL-37 totally reversed ...
Objective: Ferritin, an iron-binding protein, is ubiquitous and highly conserved; it plays a crucial role in inflammation, which is the main symptom of periodontitis. Full-length cDNA library analyses have demonstrated abundant expression of ferritin in human periodontal ligament. The aims of the present study were to explore how ferritin is regulated by local inflammation, and to investigate its functions and mechanisms of action in the process of periodontitis. Methods: Human gingival tissues were collected from periodontitis patients and healthy individuals. Experimental periodontitis was induced by ligature of second molars in mice. The expression of ferritin light polypeptide (FTL) and ferritin heavy polypeptide (FTH) were assessed by immunohistochemistry. Meanwhile, after stimulating human periodontal ligament cells (HPDLCs) with P. gingivalis-lipopolysaccharide (LPS), interleukin (IL)-6, and tumor necrosis factor-α (TNF-α), the expression of FTH and FTL were measured. Then, IL-6 and ...
The oral cavity is a complex environment in which periodontal tissue is constantly stimulated by external microorganisms and mechanical forces. Proper mechanical force helps maintain periodontal tissue homeostasis, and improper inflammatory response can break the balance. Periodontal ligament (PDL) cells play crucial roles in responding to these challenges and maintaining the homeostasis of periodontal tissue. However, the mechanisms underlying PDL cell property changes induced by inflammatory and mechanical force microenvironments are still unclear. Recent studies have shown that exosomes function as a means of cell-cell and cell-matrix communication in biological processes. Human periodontal ligament stem cells (HPDLSCs) were tested by the CCK8 assay, EdU, alizarin red, and ALP staining to evaluate the functions of exosomes induced by a mechanical strain. MicroRNA sequencing was used to find the discrepancy miRNA in exosomes. In addition, real-time PCR, FISH, luciferase reporter assay, and western
Fibroblast growth factor 2 (FGF2) has been revealed to promote human periodontal ligament stem cell (PDLSC) proliferation. The abnormal proliferation of PDLSCs has also been associated with the pathogenesis of periodontitis. The long non‑coding RNA, metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), has been demonstrated to regulate FGF2 secretion. Therefore, MALAT1 may also be associated with periodontitis. The aim of the present study was to investigate the effect of MALAT1 overexpression on the proliferation of PDLSCs. In the current study, PDLSCs derived from healthy and periodontitis‑affected teeth were collected. MALAT1 and FGF2 mRNA expression in PDLSCs was detected using reverse transcription‑quantitative PCR. PDLSCs overexpressing MALAT1 were subsequently generated. PDLSC proliferation was analyzed using a Cell Counting kit‑8 assay. FGF2 protein expression was detected using western blot analysis. The results revealed that MALAT1 and FGF2 mRNA were significantly ...
Objective: This study aimed to investigate the roles of long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) in osteogenic differentiation of periodontal ligament stem cells (PDLSCs) in periodontitis.Methods: Differentially expressed lncRNAs and mRNAs between periodontitis periodontal ligament tissues and healthy periodontal ligament tissues were selected out using R project. PDLSCs were identified using flow cytometry. Western blot was employed to detect pathway relative proteins. Besides, targeted relationships between lncRNA and miRNA, as well as miRNA and mRNA were verified by dual luciferase reporter gene assay. Osteogenic differentiation of PDLSCs was assessed by alkaline phosphatase (ALP) staining and Alizarin Red Staining (ARS). Markers for osteoblast (Runx2, Osterix, Osteocalcin, Colla1) were detected using western blot.Results: LncRNA MEG3 and IGF1 were both down-regulated, while miR-27a-3p was up-regulated in periodontitis samples compared with healthy samples. Overexpression
The purpose of this study is to compare the properties of dental pulp and periodontal ligament stem cells from extracted supernumerary teeth by quantitative real-time PCR. Impacted supernumerary teeth in the maxillary anterior region were extracted. Dental pulp and periodontal ligament cells were collected from extracted supernumerary teeth on the same day. After isolation and culture of cells, compare characterization of them by using qRT-PCR. Primer sequences for odontoblasts are ONT, ALP, OC
Cryopreservation has been extensively applied to the long-term storage of a diverse range of biological materials. However, no comprehensive study is currently available on the cryopreservation of periodontal ligament stem cell (PDLSC) sheets which have been suggested as excellent transplant materials for periodontal tissue regeneration. The aim of this study is to investigate the effect of cryopreservation on the structural integrity and functional viability of PDLSC sheets. PDLSC sheets prepared from extracted human molars were divided into two groups: the cryopreservation group (cPDLSC sheets) and the freshly prepared control group (fPDLSC sheets). The cPDLSC sheets were cryopreserved in a solution consisting of 90% fetal bovine serum and 10% dimethyl sulfoxide for 3 months. Cell viability and cell proliferation rates of PDLSCs in both groups were evaluated by cell viability assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, respectively. The multilineage
TY - JOUR. T1 - Osteoblastic differentiation of periodontal ligament stem cells on non-stoichiometric calcium phosphate and titanium surfaces. AU - Winning, L. AU - Robinson, L. AU - Boyd, A. R.. AU - El Karim, I A. AU - Lundy, F T. AU - Meenan, BJ. N1 - Compliant in UIR; evidence uploaded to Other files Reference text: 1 Olivares-Navarrete R, Hyzy SL, Park JH, Dunn GR, Haithcock DA, Wasilewski CE, Boyan BD, Schwartz Z. Mediation of osteogenic differentiation of human mesenchymal stem cells on titanium surfaces by a Wnt-integrin feedback loop. Biomaterials 2011;32:6399-6411. CrossRef , PubMed , CAS , Web of Science® Times Cited: 50 2 Rausch-fan X, Qu Z, Wieland M, Matejka M, Schedle A. Differentiation and cytokine synthesis of human alveolar osteoblasts compared to osteoblast-like cells (MG63) in response to titanium surfaces. Dent Mater 2008 ;24:102-110. Jan CrossRef , PubMed , CAS , Web of Science® Times Cited: 71 3 Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, ...
During the last decade it has become clear that periodontal ligament fibroblasts may contribute to the in vitro differentiation of osteoclasts. We surveyed the current findings regarding their osteoclastogenesis potential. Periodontal ligament fibroblasts have the capacity to select and attract osteoclast precursors and subsequently to retract and enable migration of osteoclast precursors to the bone surface. There, fusion of precursors takes place, giving rise to osteoclasts. The RANKL-RANK-osteoprotegerin (OPG) axis is considered crucial in this process. Periodontal ligament fibroblasts produce primarily OPG, an osteoclastogenesis-inhibitory molecule. However, they may be influenced in vivo by direct or indirect interactions with bacteria or by mechanical loading. Incubation of periodontal ligament fibroblasts with bacteria or bacterial components causes an increased expression of RANKL and other osteoclastogenesis-stimulating molecules, such as tumor necrosis factor-α and macrophage-colony ...
OBJECTIVE To compare the mechanotransduction caused by cyclic and static mechanical strains in human periodontal ligament fibroblasts (hPDLFs) cultured under identical conditions. MATERIALS AND METHODS hPDLFs, originating from the same donors, were exposed either to cyclic or to static tensile strain using specially designed devices and under identical culture conditions. Activation of all members of mitogen-activated protein kinases (MAPKs) was monitored by western immunoblot analysis. Expression levels of immediate/early genes c-fos and c-jun were assessed with quantitative real-time polymerase chain reaction. RESULTS Time course experiments revealed that both types of stresses activate the three members of MAPK, that is ERK, p38, and JNK, with cyclic stress exhibiting a slightly more extended activation. Further downstream, both stresses upregulate the immediate/early genes c-fos and c-jun, encoding components of the activator protein-1 (AP-1), a key transcription factor in osteoblastic ...
Over the last years, electronic cigarettes (ECs) have become more popular, particularly in individuals who want to give up smoking tobacco. The aim of the present study was to assess the influence of the different e-smoking liquids on the viability and proliferation of human periodontal ligament fibroblasts. For this study six test solutions with components from ECs were selected: lime-, hazelnut- and menthol-flavored liquids, nicotine, propylene glycol, and PBS as control group. The fibroblasts were incubated up to 96 h with the different liquids, and cell viability was measured by using the PrestoBlue® reagent, the ATP detection and the migration assay. Fluorescence staining was carried out to visualize cell growth and morphology. Data were statistically analyzed by two-tailed one-way ANOVA. The cell viability assay showed that the proliferation rates of the cells incubated with nicotine or the various flavored liquids of the e-cigarettes were reduced in comparison to the controls, though not all
Bone repair by periodontal ligament stem cell-seeded nanohydroxyapatite-chitosan scaffold Shaohua Ge,1 Ning Zhao,1 Lu Wang,1 Meijiao Yu,1 Hong Liu,2 Aimei Song,1 Jing Huang,1 Guancong Wang,2 Pishan Yang11Key Laboratory of Oral Biomedicine of Shandong Province, Department of Periodontology, School of Stomatology, 2Center of Bio and Micro/Nano Functional Materials, State Key Laboratory of Crystal Materials, Shandong University, Jinan, ChinaBackground: A nanohydroxyapatite-coated chitosan scaffold has been developed in recent years, but the effect of this composite scaffold on the viability and differentiation of periodontal ligament stem cells (PDLSCs) and bone repair is still unknown. This study explored the behavior of PDLSCs on a new nanohydroxyapatite-coated genipin-chitosan conjunction scaffold (HGCCS) in vitro as compared with an uncoated genipin-chitosan framework, and evaluated the effect of PDLSC-seeded HGCCS on bone repair in vivo.Methods: Human PDLSCs were cultured and identified, seeded on a
Background and Objective: Cell adhesion plays important roles in maintaining the structural integrity of connective tissues and sensing changes in the biomechanical environment of cells. The objective of the present investigation was to extend our understanding of the effect of cyclic mechanical strain on the expression of adhesion-related genes by human periodontal ligament cells. Material and Methods: Cultured periodontal ligament cells were subjected to a cyclic in-plane tensile deformation of 12% for 5s (0.2Hz) every 90s for 6-24h in a Flexercell FX-4000 Strain Unit. The following parameters were measured: (i)cell viability by the MTT assay; (ii)caspase-3 and -7 activity; and (iii)the expression of 84 genes encoding adhesion-related molecules using real-time RT-PCR microarrays. Results: Mechanical stress reduced the metabolic activity of deformed cells at 6h, and caspase-3 and -7 activity at 6 and 12h. Seventy-three genes were detected at critical threshold values <35. Fifteen showed a ...
1. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366:1809-20 2. Khan SA, Kong EF, Meiller TF, Jabra-Rizk MA. Periodontal Diseases: Bug Induced, Host Promoted. PLoS Pathog. 2015;11(7):e1004952 3. Larsson L, Decker AM, Nibali L, Pilipchuk SP, Berglundh T, Giannobile WV. Regenerative Medicine for Periodontal and Peri-implant Diseases. J Dent Res. 2016;95:255-66 4. Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J. et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004;364:149-55 5. Nagatomo K, Komaki M, Sekiya I, Sakaguchi Y, Noguchi K, Oda S. et al. Stem cell properties of human periodontal ligament cells. J Periodontal Res. 2006;41:303-10 6. Bartold PM, Shi S, Gronthos S. Stem cells and periodontal regeneration. Periodontol 2000. 2006;40:164-72 7. Boisselier E, Astruc D. Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. Chem Soc Rev. 2009;38:1759-82 8. Khlebtsov ...
Eur J Pharmacol. 2011 Nov 16;670(1):295-303. doi: 10.1016/j.ejphar.2011.08.008. Epub 2011 Sep 2. Research Support, Non-U.S. Govt
TY - JOUR. T1 - Cyclic stretch force induces periodontal ligament cells to secrete exosomes that suppress IL-1β production through the inhibition of the NF-κB signaling pathway in macrophages. AU - Wang, Zhuyu. AU - Maruyama, Kentarou. AU - Sakisaka, Yukihiko. AU - Suzuki, Shigeki. AU - Tada, Hiroyuki. AU - Suto, Mizuki. AU - Saito, Masahiro. AU - Yamada, Satoru. AU - Nemoto, Eiji. PY - 2019/1/1. Y1 - 2019/1/1. N2 - In the oral mechanical environment, periodontal ligament cells (PDL cells) contribute to maintaining periodontal tissue homeostasis. Recent studies showed that exosomes, which are small vesicles secreted by various types of cells, play a pivotal role in cell-to-cell communication in biological processes. We examined the secretion of exosomes from PDL cells stimulated with cyclic stretch and their role in the inflammatory response of macrophages using the human macrophage cell line THP-1 and human primary monocytes/macrophages. We prepared supernatants from human PDL cells (PDL-sup) ...
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Effects of TGF-β1 on the proliferation and differentiation of human periodontal ligament cells and a human periodontal ligament stem/progenitor cell line (2010 ...
Principal Investigator:KAWASE Toshio, Project Period (FY):1991 - 1992, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Functional basic dentistry
Define periodontal ligament nerve. periodontal ligament nerve synonyms, periodontal ligament nerve pronunciation, periodontal ligament nerve translation, English dictionary definition of periodontal ligament nerve. n. 1. Any of the cordlike bundles of fibers made up of neurons through which sensory stimuli and motor impulses pass between the brain or other parts of the...
Definition of fibrous, of periodontal ligament matrix in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is fibrous, of periodontal ligament matrix? Meaning of fibrous, of periodontal ligament matrix as a finance term. What does fibrous, of periodontal ligament matrix mean in finance?
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BACKGROUND: Growth hormone (GH) is a potent regulator of bone formation. The proposed mechanism of GH action is through the stimulation of osteogenic precursor cell proliferation and, following clonal expansion of these cells, promotion of differentiation along the osteogenic lineage. OBJECTIVES: We tested this hypothesis by studying the effects of GH on primary cell populations of human periodontal ligament cells (PLC) and alveolar bone cells (ABC), which contain a spectrum of osteogenic precursors. METHODS: The cell populations were assessed for mineralization potential after long-term culture in media containing beta-glycerophosphate and ascorbic acid, by the demonstration of mineral deposition by Von Kossa staining. The proliferative response of the cells to GH was determined over a 48-h period using a crystal violet dye-binding assay. The profile of the cells in terms of osteogenic marker expression was established using quantitative reverse transcriptase polymerase chain reaction (RT-PCR) ...
Although previous studies have demonstrated that hydrogen sulfide (H2S) stimulated or inhibited osteoclastic differentiation, little is known about the effects of H2S on the differentiation of osteoblasts and osteoclasts. To determine the possible bioactivities of H2S on bone metabolism, we investigated the in vitro effects of H2S on cytotoxicity, osteoblastic, and osteoclastic differentiation as well as the underlying mechanism in lipopolysaccharide (LPS) and nicotine-stimulated human periodontal ligament cells (hPDLCs). The H2S donor, NaHS, protected hPDLCs from nicotine and LPS-induced cytotoxicity and recovered nicotine- and LPS-downregulated osteoblastic differentiation, such as alkaline phosphatase (ALP) activity, mRNA expression of osteoblasts, including ALP, osteopontin (OPN), and osteocalcin (OCN), and mineralized nodule formation. Concomitantly, NaHS inhibited the differentiation of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts in mouse bone marrow cells and blocked ...
Human periodontal ligament stem cells (hPDLSCs) are best seed cells for periodontal regeneration. A larger understanding of the dynamic protein profiles throughout osteogenic differentiation contributed to the advance of periodontal regeneration tissue engineering. Tandem Mass Tag quantitative proteomics was utilized to disclose the temporal protein expression sample throughout osteogenic differentiation of hPDLSCs on days.... ...
Human periodontal ligament stem cells (hPDLSCs) are best seed cells for periodontal regeneration. A larger understanding of the dynamic protein profiles throughout osteogenic differentiation contributed to the advance of periodontal regeneration tissue engineering. Tandem Mass Tag quantitative proteomics was utilized to disclose the temporal protein expression sample throughout osteogenic differentiation of hPDLSCs on days.... ...
The aim of this study was to observe the time-lapse changes in the rat periodontal ligament (PDL) during function and tooth movement. Under Nembutal anaesthesia, time-lapse changes in the thickness of the PDL of the first molars were investigated in five 12-week-old adolescent rats with microcomputed tomography. Three-dimensional (3D) images were reconstructed from the data. Histological observation was also performed, using undecalcified frozen sections of the maxillary first molar area.. The PDL appeared as a radiolucent furrow on the 3D images. A slight change in the thickness of the PDL was observed 1 hour after initiation of orthodontic force loading, which became significant after 6 hours, with the appearance of pressure-tension zones during the tooth movement. These changes were more significant 3 days after orthodontic loading.. Histological observation of the lingual cervical PDL (pressure zone) in nine 12- to 13-week-old rats demonstrated that the periodontal space had become narrow ...
Periodontal ligament stem cells (PDLSCs) represent a good source of multipotent cells for cell-based therapies in regenerative medicine. The success rate of these treatments is severely dependent on the establishment of adequate vasculature in order to provide oxygen and nutrients to the transplanted cells. Pharmacological preconditioning of stem cells has been proposed as a promising method to augment their therapeutic efficacy. In this study, the aim was to improve the intrinsic angiogenic properties of PDLSCs by in vitro pretreatment with deferoxamine (DFX; 100μM), fibroblast growth factor-2 (FGF-2; 10ng/mL) or both substances combined. An antibody array revealed the differential expression of several proteins, including vascular endothelial growth factor (VEGF) and placental growth factor (PlGF). ELISA data confirmed a 1.5 to 1.8-fold increase in VEGF for all tested conditions. Moreover, 48 hours after the removal of DFX, VEGF levels remained elevated (1.8-fold) compared to control conditions. FGF
TY - JOUR. T1 - Coexpression of calretinin and parvalbumin in Ruffini-like endings in the rat incisor periodontal ligament. AU - Ichikawa, Hiroyuki. AU - Jacobowitz, David M.. AU - Sugimoto, Tomosada. PY - 1997/10/3. Y1 - 1997/10/3. N2 - The coexpression of calretinin- (CR) and parvalbumin-immunoreactivities (irs) was examined in oro-facial tissues of the rat. Nerve fibers coexpressing these calcium-binding proteins (CaBPs) were observed in the lingual periodontal ligament of incisors but not other tissues. In the part of periodontal ligament adjacent to the alveolar bone, such nerve fibers left nerve bundles and formed bush-like endings, i.e., they ramified repeatedly and terminated with one to four twigs. An immunoelectron microscopic method indicated that these endings were identical to Ruffini- like endings. 4% of trigeminal neurons retrogradely labeled from the inferior alveolar nerve coexpressed CR- and parvalbumin-irs. The present observations suggest that the coexpression of these CaBPs ...
Monkey periodontal ligament fibroblasts (MPLF cells), human gingival fibroblasts (HGF cells), rat embryonic calvaria cells (REC cells), porcine periodontal ligament epithelial cells (PPLE cells) and rat osteosarcoma 17/2 cells (ROS cells) were incorporated into 3-dimensional collagen gels plated in 60 mm Petri dishes in order: first, to measure the capacity of these cell types to contract; second, to investigate cell-collagen and intercellular relationships during contraction; and third, to define the cellular contribution to tissue contraction in an in vitro system. Measurements at times up to 72 h on 3 ml gels containing 5 × 10(5) cells and with a collagen concentration of 1.20 mg/ml showed that MPLF cells contracted the gels at a significantly greater rate (P less than 0.001) than did the other cell types. In addition, contraction started sooner and was of greater extent than with the other cells. HGF cells contracted the gels more rapidly than REC and PPLE cells, while ROS cells caused no ...
Recently, inflammation has been recognised as an important co-requisite to orthodontic tooth movement. When such a reaction is initiated, the process of up-regulation of certain adhesion molecules may occur, resulting in the extravasation of leukocytes. This may stimulate progenitor/precursor pathways and signals that regulate the biological responses resulting in tooth movement. We propose that up-regulation of leukocyte adhesion molecules occurs in response to orthodontic forces, resulting in circulating monocyte attraction, extravasation and differentiation into osteoclasts, which are responsible for bone resorption that results in orthodontic tooth movement. To investigate this hypothesis, it is necessary to determine whether periodontal ligament (PDL) endothelium responds to inflammatory stimuli as other organs do. We studied the normal distribution of endothelial adhesion molecule ICAM-1 within PDL vessels, and then the following exposure to an inflammatory endotoxin. The rat PDL blood vessels
Purpose/Aim: Cementogenesis is a critical step in periodontal tissue regeneration given the essential role of cementum in anchoring teeth to the alveolar bone. This study is designed to achieve integrated cementum formation on the root surfaces of human teeth using growth factor-releasing scaffolds with periodontal ligament stem/progenitor cells (PDLSCs). Materials and methods: Human PDLSCs were sorted by CD146 expression, and characterized using CFU-F assay and induced multi-lineage differentiation. Polycaprolactone scaffolds were fabricated using 3D printing, embedded with poly(lactic-co-glycolic acids) (PLGA) microspheres encapsulating connective tissue growth factor (CTGF), bone morphogenetic protein-2 (BMP-2), or bone morphogenetic protein-7 (BMP-7). After removing cementum on…. ...
Recently, research has focused intensely on age-related tissue changes, not only in the field of aesthetic dermatology but also in the dental field. Judging from clinical experience, relevant changes were suspected in the periodontal tissue thus influencing orthodontic tooth movement and the progression of periodontal disease.. Evidence was found that orthodontic tooth movement seems to be impaired in adult patients, thus requiring different treatment protocols than in adolescent patients. These findings will be discussed more thoroughly later in this article.. Periodontal disease however seems to be less dependent on age [1]. A study comparing experimental gingivitis in young vs. old individuals by Fransson et al. [2, 3] did confirm that older individuals experience more severe inflammation in response to experimental gingivitis. Nevertheless, several studies evaluating whether age is a risk factor for increased loss of periodontal support, have shown that aging either has no effect at all or, ...
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The cells of cementum are the entrapped cementoblasts, the cementocytes. Each cementocyte lies in its lacuna, similar to the pattern noted in bone. These lacunae also have canaliculi or canals. Unlike those in bone, however, these canals in cementum do not contain nerves, nor do they radiate outward. Instead, the canals are oriented toward the periodontal ligament and contain cementocytic processes that exist to diffuse nutrients from the ligament because it is vascularized. After the apposition of cementum in layers, the cementoblasts that do not become entrapped in cementum line up along the cemental surface along the length of the outer covering of the periodontal ligament. These cementoblasts can form subsequent layers of cementum if the tooth is injured. Sharpey fibers are part of the principal collagenous fibers of the periodontal ligament embedded in the cementum and alveolar bone to attach the tooth to the alveolus.[2] ...
It is generally thought that the physical change of expanding the dental alveolar bone (socket) along with the severing of the periodontal ligament is the basis of a tooth extraction. Albeit that this does happen, an understanding of what is occurring biochemically is even more important. When the periodontal ligament is traumatized with forceps or elevators, hyaluronidase (hyaluronate glycanohydrolase) is released. This is an enzyme that catalyzes the hydrolysis of the interstitial barrier, hyaluronan (hyaluronic acid), which is the cement substance (extracellular matrix) of all human tissue. Once this chemical breakdown of the periodontal ligament by hyaluronidase is sufficient, the tooth is released from its attachment to the alveolus and can be removed.. This explains why the PHYSICS FORCEPS, with its steady unrelenting trauma to the periodontal ligament, quantitatively creates a greater release of hyaluronidase in a shorter period of time than traditional forceps or elevators extractions ...
Background: Bone marrow-derived cells (BMCs) have capabilities of cell migration and differentiation into cells/organs in the body and related with the differentiation of teeth or periodontal cells including fibroblasts. the periodontal cells. Results: The immunohistochemistry exposed that GFP positive cells were recognized in the periodontal cells, both in the experimental and control specimens. The percentage of pixel quantity in the exam group showed 5.77 3.24 % (mean SD); and that in the control group, 0.710.45 % (mean SD). The exam group was significantly greater than that of control group (Mann-Whitney U test: p 0.001). Summary: These results suggest that orthodontic mechanical stress accelerates transplanted BMC migration into periodontal cells. strong class=kwd-title Keywords: bone marrow-derived cell (BMC), periodontal cells, green fluorescent protein (GFP), mechanical stress, fibroblast. Intro It has been known that some kinds of stem cells have the impressive properties of ...
Periodontitis is a chronic destructive category of periodontal disease that progresses to the resorption of alveolar bone, which leads to progressive bone destruction and tooth loss. As a consequence of resorption, breakdown of products are released into periodontal tissues, migrating toward the gingival sulcus and gathering from the surrounding site in whole saliva, where several of them have been identified. 2930. Among the several host enzymes proposed as diagnostic indicators of periodontal status, ALP was one of the first to be identified. 31 ALP is released from polymorphonuclear cells (PMNs) during inflammation 10 and from osteoblasts 32 and periodontal ligament fibroblasts 33 during bone formation and periodontal regeneration respectively.. ALP activity in serum has been extensively studied, and it was suggested that ALP allows bone mineralization by releasing an organic phosphate that contributes to the deposition of calcium phosphate complexes into the osteoid matrix. 3435 ALP might ...
THE ANATOMICAL RECORD 222:191-200 (1988) Radioautographic Demonstration of Receptors for Epidermal Growth Factor in Various Cells of the Oral Cavity MOON-IL CHO, YU LIN LEE, AND PHILIAS R. GARANT Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook, New York 11794-8700 ABSTRACT Mouse iodinated epidermal growth factor (EGF)was localizedby light and electron microscopic radioautography in basal cells of oral epithelium, papillary cells of the enamel organ, periodontal ligament fibroblasts, preodontoblast precursor cells, and preosteoblasts of the alveolar bone of 13-day-old Sprague-Dawleyrats. The specificity of binding in these cells was suggested by an observed reduction of about 90% in the labeling when excess unlabeled EGF was injected along with the 125I-EGF. In contrast, fully differentiated cells, such as ameloblasts. odontoblasts, and osteoblasts, were only poorly labeled. Quantitative analysis of the light microscopic ...
The aim of this study was to assess the impact of 1α,25-dihydroxyvitamin D3 (vitamin D3) on osteogenic and inflammatory properties of human periodontal ligament (PDL) cells and investigate underlying mechanisms ...
Primary Tooth A primary tooth that has been avulsed is usually not reimplanted. The risk of injury to the developing permanent tooth bud is high. Permanent Tooth Do not touch the root of the tooth. Handle the tooth by the crown only. Rinse the tooth off only if covered by debris. Do not scrub or scrape the tooth. Attempt to reimplant the tooth into the socket with gentle pressure, and hold it in position. Hold the tooth in place. Aluminium foil may be used to help stabilise the tooth, or the patient can bite gently on gauze or a soft cloth. Time is critical and immediate replacement is best, and ideally should not be delayed more than 30 minutes. If unable to reimplant the tooth, place it in a protective transport solution, such as Hanks solution, milk, saline, or placing it in the patients mouth next to the cheek, if the patient is able to do so. This will hydrate and nourish the periodontal ligament cells which are still attached to the root. A small container of Hanks Balanced Salt ...
Primary Tooth A primary tooth that has been avulsed is usually not reimplanted. The risk of injury to the developing permanent tooth bud is high. Permanent Tooth Do not touch the root of the tooth. Handle the tooth by the crown only. Rinse the tooth off only if covered by debris. Do not scrub or scrape the tooth. Attempt to reimplant the tooth into the socket with gentle pressure, and hold it in position. Hold the tooth in place. Aluminium foil may be used to help stabilise the tooth, or the patient can bite gently on gauze or a soft cloth. Time is critical and immediate replacement is best, and ideally should not be delayed more than 30 minutes. If unable to reimplant the tooth, place it in a protective transport solution, such as Hanks solution, milk, saline, or placing it in the patients mouth next to the cheek, if the patient is able to do so. This will hydrate and nourish the periodontal ligament cells which are still attached to the root. A small container of Hanks Balanced Salt ...
Supplementary MaterialsNIHMS923971-supplement-supplement_1. and could end up being amenable to healing reversal. Launch Periodontitis, a bacterially-mediated chronic inflammatory disease from the tissue supporting the teeth is among the most common inflammatory illnesses in human beings and it could adversely influence systemic wellness (Armitage, 2004, Armitage, 2008). Country wide surveys show that most adults have problems with mild-to-moderate periodontitis, with up to 15% of the populace suffering from severe forms during their lives (Pihlstrom research further indicate these FN fragments, induce many detrimental results, including induction of apoptosis and suppression of osteoblast differentiation of periodontal ligament cells (Kapila along with and be prevalent in past due levels of subgingival biofilm formation and consist of the bacterial reddish colored complicated that is regarded pathogenic in the etiology of periodontal disease (Socransky frequently predominate in periodontal ...
The restoring of the periodontal tissue and reduction of inflammation are the goals of nonsurgical periodontal therapy. Studies have been completed to study the effect Chlorhexidine (CHX) has on periodontal ligament ...
Background. Stem cells have contributed to the development of tissue-engineered-based regenerative periodontal therapies. In order to find the best stem cell sources for such therapies, the biologic properties of stem cells isolated from periodontal ligaments (PDL) of deciduous (DePDLSC) and permanent (PePDLSC) teeth were comparatively evaluated. Methods. PDL stem cells were isolated from six sound fully erupted premolars and six deciduous canines of healthy subjects. In vitro biologic characteristics such as colony formation, viability, stem cell marker identification and osteogenic differentiation (using alkaline phosphatase analysis and Alizarin red staining) were comparatively assessed using one-way ANOVA and post hoc Tukey tests using SPSS 13 ...
Recombinant Human Programmed cell death 1 ligand 1 (PDL1), CD274, B7 homolog 1 (B7-H1) Protein produced in human 293 cells, C-mFc Tag
Looking for online definition of Malassez epithelial rests in the Medical Dictionary? Malassez epithelial rests explanation free. What is Malassez epithelial rests? Meaning of Malassez epithelial rests medical term. What does Malassez epithelial rests mean?
The therapeutic strategies for neurodegenerative diseases still represent a vast research field because of the lack of targeted, effective and resolutive treatment for neurodegenerative diseases. The use of stem cell-based therapy is an alternative approach that could lead to the replacement of damaged neuronal tissue. For this purpose, adult mesenchymal stem cells (MSC), including periodontal ligament stem cells (PDLSCs), could be very useful for their differentiation capacity, easy isolation and the ability to perform an autologous implant. The aim of this work was to test whether the Moringin [4-(α-L-rhamnosyloxy) benzyl isothiocyanate; GMG-ITC], an isothiocyanate extracted from Moringa oleifera seeds, was able to induce PDLSCs toward neural progenitor differentiation. Next-generation transcriptomics sequencing showed that moringin treatment increased the expression of genes involved in neuron cortical development and in particular in neuron belonging to upper and deep cortical layers. ...
Looking for online definition of periodontal ligament in the Medical Dictionary? periodontal ligament explanation free. What is periodontal ligament? Meaning of periodontal ligament medical term. What does periodontal ligament mean?
Fingerprint Dive into the research topics of Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and Vaniloid 4 (TRPV4) in human PDL cells. Together they form a unique fingerprint. ...
Cytotoxicity of a novel nano-silver particle endodontic irrigant Eric LK Chan,1 Chengfei Zhang,2 Gary SP Cheung2 1Department of Health, Government of Hong Kong SAR, Hong Kong, Special Administrative Region; 2Comprehensive Dental Care (Endodontics), Faculty of Dentistry, University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China Purpose: The aim of this study was to evaluate the cytotoxic effect of a novel nano-silver particle (25.2±6.5 nm) endodontic irrigant (0.2 mM) and compare it with 3% sodium hypochlorite. Materials and methods: Two cell types, mouse fibroblast National Institutes of Health 3T3 (NIH 3T3) and primary human periodontal ligament stem cell (hPDLSCs) were used in a test for the effect of direct and indirect (by separating the agent and cell with a layer of agar) exposure to the two solutions. In the direct exposure experiment, ten groups of cell cultures were exposed to one dilution (3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6 or 1:7) of a
TY - JOUR. T1 - Comparative gene-expression analysis of the dental follicle and periodontal ligament in humans. AU - Lee, Hyo Seol. AU - Lee, Jongeun. AU - Kim, Seong Oh. AU - Song, Je Seon. AU - Lee, Jae Ho. AU - Lee, Syng Ill. AU - Jung, Han Sung. AU - Choi, Byung Jai. PY - 2013/12/23. Y1 - 2013/12/23. N2 - The human dental follicle partially differentiates into the periodontal ligament (PDL), but their biological functions are different. The gene-expression profiles of the dental follicle and PDL were compared using the cDNA microarray technique. Microarray analysis identified 490 genes with a twofold or greater difference in expression, 365 and 125 of which were more abundant in the dental follicle and PDL, respectively. The most strongly expressed genes in the dental follicle were those related to bone development and remodeling (EGFL6, MMP8, FRZB, and NELL1), apoptosis and chemotaxis (Nox4, CXCL13, and CCL2), and tooth and embryo development (WNT2, PAX3, FGF7, AMBN, AMTN, and SLC4A4), ...
It is well-documented that both chemokine (C-C motif) ligand 19 (CCL19) and 21 (CCL21) mediate cell migration and angiogenesis in many diseases. However, these ligands precise pathological role in ankylosing spondylitis (AS) has not been elucidated. The objective of this study was to examine the expression of CCL19 and CCL21 (CCL19/CCL21) in AS hip ligament tissue (LT) and determine their pathological functions. The expression levels of CCL19, CCL21 and their receptor CCR7 in AS (n = 31) and osteoarthritis (OA, n = 21) LT were analyzed via real-time polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC). The expression of CCL19, CCL21 and CCR7 in AS ligament fibroblasts was also detected. The proliferation of ligament fibroblasts was measured via a cell counting kit-8 (CCK8) assay after exogenous CCL19/CCL21 treatment. Additionally, the role of CCL19/CCL21 in osteogenesis was evaluated via RT-PCR and enzyme-linked immunosorbent assay (ELISA) in individual AS fibroblast cultures. Furthermore,
The lateral periodontal cyst is a non-inflammatory developmental cyst that arises from the epithelial post-functional dental lamina, which is a remnant from odontogenesis. It is more common in middle-aged males. Usually asymptomatic, it presents as a regular well-corticated radiolucency on the side of a mandibular canine or premolar root. Histologically, the cyst appears similar to the gingival cyst of the adult, having a non-keratinized squamous epithelial lining. The involved tooth is usually vital and has no indication for root canal treatment unless the signs of non-vital or necrotic pulpal tissue were confirmed. The cysts arise from epithelial rest cells in the periodontal ligament, although it is unknown whether from the cell rests of Malassez, reduced enamel epithelium or dental lamina remnants, and are generally treated by surgical enucleation. Altini M, Shear M. The lateral periodontal cyst: an update. J Oral Pathol Med. 1992 Jul; 21(6):245-50. Wood K, Goaz P. 5th ed. St. Louis: Mosby; ...
Sigma-Aldrich offers abstracts and full-text articles by [Hong-Shi Li, Jie Ke, Gui-Zhi Zhao, Li-An Wu, Jun-Ping Kou, Hong-Chen Liu].
Retention is a critical follow-through stage that typically involves wearing an orthodontic appliance called a retainer. Several different kinds of retainers are available, all of which are custom-made just for you. We will recommend the type (or types) that will work best in your situation, and well tell you exactly when and how long you need to wear them.. But if your teeth are straight now, why do you need a retainer at all? Simply put, its because if you dont wear one, your teeth will start moving right back to where they were!. Teeth arent set rigidly in the jawbone - instead, theyre held in place by a network of fibers called the periodontal ligaments. After they have been moved, it takes several months for the periodontal ligament to adjust to the new position. So if you want to keep that new smile - and not waste all the time, effort, and money it took to get it - its essential to wear your retainer as directed.. Being fitted for a retainer usually happens on the same day your ...
Retention is a critical follow-through stage that typically involves wearing an orthodontic appliance called a retainer. Several different kinds of retainers are available, all of which are custom-made just for you. We will recommend the type (or types) that will work best in your situation, and well tell you exactly when and how long you need to wear them.. But if your teeth are straight now, why do you need a retainer at all? Simply put, its because if you dont wear one, your teeth will start moving right back to where they were!. Teeth arent set rigidly in the jawbone - instead, theyre held in place by a network of fibers called the periodontal ligaments. After they have been moved, it takes several months for the periodontal ligament to adjust to the new position. So if you want to keep that new smile - and not waste all the time, effort, and money it took to get it - its essential to wear your retainer as directed.. Being fitted for a retainer usually happens on the same day your ...
TY - JOUR. T1 - Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor β. AU - Horiuchi, Keisuke. AU - Amizuka, Norio. AU - Takeshita, Sunao. AU - Takamatsu, Hiroyuki. AU - Katsuura, Mieko. AU - Ozawa, Hidehiro. AU - Toyama, Yoshiaki. AU - Bonewald, Lynda F.. AU - Kudo, Akira. PY - 1999/7/17. Y1 - 1999/7/17. N2 - We had previously identified the cDNA for a novel protein called osteoblast-specific factor 2 (OSF-2) from an MC3T3-E1 cDNA library using subtraction hybridization and differential screening techniques. Here we describe the localization, regulation, and potential function of this protein. Immunohistochemistry using specific antiserum revealed that in adult mice, the protein is preferentially expressed in periosteum and periodontal ligament, indicating its tissue specificity and a potential role in bone and tooth formation and maintenance of structure. ...
The ACP Education Foundation is proud to announce the recipient of the 2015 GSK Prosthodontist Innovator Award.. Dr. Alireza Moshaverinia is a tenure-track assistant professor at the UCLA School of Dentistry. His research, titled Novel Multifunctional Polymeric Membrane for Periodontal Tissue Engineering, aims to develop a novel bioactive smart membrane for periodontal tissue regeneration and promising treatment approach for maxillofacial and skeletal defects.. More information on this educational grant:. ...
Orthodontic treatment (commonly known as braces) can be a lengthy process to re-align your teeth to a more functional and aesthetic position. Once the orthodontic devices are removed, however, the treatment isnt finished. Wearing a retainer is the final step to ensuring that the re-alignment doesnt eventually fail. Its designed to do just what its name implies - to retain the teeths new position and prevent a relapse to the old.. This can happen because of the way teeth fit into the jaw bone. The teeth are joined to the bone by the periodontal ligament, which works somewhat like a hammock: the ligaments fibers act like threads that fit into the tooth on one side and into the bone on the other, and hold the teeth in place.. As living tissue, the ligaments cell structure is dynamic and can adapt to the gentle pressure applied by an orthodontic device. However, once this pressure subsides after the device is removed muscle memory can cause the ligament to resist the new position and pull ...
Normal Periodontium and its components including gingiva, periodontal ligament, cementum, alveolar bone. Formation, classification and functions of these components.
Molecules involved in periodontal regeneration, Cytokines, Growth factors, Adhesion molecules, Fibroblast growth factor-1 and -2, Bone morphogenetic proteins, Insulin-like growth factor-I and II, Platelet-derived growth factor.
Fu, J.-H.,Wang, H.-L. (2013-04-05). Clinical Correlate: Periodontal Regeneration. Mineralized Tissues in Oral and Craniofacial Science: Biological Principles and Clinical Correlates : 201-205. [email protected] Repository. https://doi.org/10.1002/9781118704868.ch23 ...
Those of us that have worn braces during childhood have probably never realized that this force on teeth evokes unique cellular responses of the cells that are located in the tiny gap of approximately 0.1 millimeter between the tooth and the bone socket into which the tooth is embedded. Teeth migrate through bone by induction of bone break-down at the pull-side and by inducing bone formation at the push-side. The space between tooth and bone is the periodontal ligament, and, similar to muscle-to-bone ligaments that are more commonly known, fibroblasts from this ligament secure tight anchoring of teeth into bone. READ MORE ...
Periodontal or gum disease is a common condition affecting the tissues that comprise the dental supporting structure: gingiva, cementum, periodontal ligament, and the alveolar bone (). Periodontal disease is broadly classified as either gingivitis or
The tooth is an ectodermal organ that arises from a tooth germ under the regulation of reciprocal epithelial-mesenchymal interactions. Tooth morphogenesis occurs in the tooth-forming field as a result of reaction-diffusion waves of specific gene expression patterns. Here, we developed a novel mechanical ligation method for splitting tooth germs to artificially regulate the molecules that control tooth morphology. The split tooth germs successfully developed into multiple correct teeth through the re-regionalisation of the tooth-forming field, which is regulated by reaction-diffusion waves in response to mechanical force. Furthermore, split teeth erupted into the oral cavity and restored physiological tooth function, including mastication, periodontal ligament function and responsiveness to noxious stimuli. Thus, this study presents a novel tooth regenerative technology based on split tooth germs and the re-regionalisation of the tooth-forming field by artificial mechanical force ...
Upon occasion, when a live nerve becomes irritated (in this case due to the close proximity of the filling), it may become sick and forget its usual function of remaining inert and keeping the tooth hydrated. When this happens, it may start to eat away at the very tooth that it is supposed to be protecting. The image above shows a dark (radiolucent) area in the distal (back) root next to the furcation (where the two roots join together). This radiolucency represents a hole in the tooth structure at that point. The nerve simply ate away the tooth from the inside out. This hole is an example of internal resorption.. The reason that this defect is labeled internal/external resorption is that a second phenomenon can cause the same defect. This involves cells in the periodontal ligament which forget their usual function of supporting the root of the tooth. If this happens, these external cells may eat the same hole in the tooth, this time from the outside in. Once the nerve is exposed in the ...
When braces are first applied, it can take several days to get used to the new appliances. During this time, the mouth may feel tender or sore. While soreness is rarely problematic enough to warrant additional dental care, contact your orthodontist if soreness becomes highly uncomfortable. Causes of Orthodontic Soreness When braces are initially applied or the archwire is changed during an orthodontic adjustment appointment, teeth start to gradually shift toward their new destination. This initial movement causes adjacent tissue to become inflamed. This inflammation causes fibers that join the teeth to the jawbone and gums (periodontal ligaments) to swell. The swelling in turn leads to compressed nerve fibers, which are the true cause of orthodontic soreness. What Can Be Done to Ease Soreness? It is important to remember that orthodontic discomfort generally decreases within a few days. After the initial affixation of braces, it can take between one and two weeks for the tissues of the tongue, ...
1. Assists in the treatment of arthritis and rheumatism:. The presence of phytochemicals in Avocado is a healthy reason for its effectiveness in the treatment of osteoarthritis and other inflammatory conditions. It is for this reason, Avocado along with the blend of Soybean oil is recommended by Denmark as a food supplement for treating inflammation and influencing the repair and growth of cartilage.. France has determined this duo oil as prescription medicine. This is further substantiated by various research analyses published in the journal Ugeschrift for laeger that have proved the usefulness of this blend in the healing of osteoarthritis in the knee and hip area.. Avocado oil inhibited a pro-inflammatory cytokine molecule states the research report published in the 2006 Journal Periodontal Disease issue, where human bone cells and periodontal ligaments were studied, thus demonstrating that Avocado oil with its anti-inflammatory values aids in reducing inflammation and preventing certain ...
Straumann® Emdogain® is a unique gel containing enamel matrix derivative. This mixture of natural proteins can induce biological processes that usually take place during the development of the periodontium and may stimulate certain cells involved in the healing process of soft and hard tissues ...
Serious gum disease is called periodontitis. Over time, this condition can break down the bones and tissues that hold teeth in place. Untreated, it can lead to tooth loss.
Paola Maffi, Torbjörn Lundgren, Gunnar Tufveson, Ehab Rafael, James A.M. Shaw, Aaron Liew, Frantisek Saudek, Piotr Witkowski, Karolina Golab, Federico Bertuzzi, Bengt Gustafsson, Luisa Daffonchio, Pier Adelchi Ruffini, Lorenzo Piemonti, the REP0211 Study Group ...
Periodontal Ligament[edit]. The periodontal ligament is the connective tissue that joins the outer layer of the tooth root, ... Periodontal diseases[edit]. Periodontal disease encompasses a number of diseases of the periodontal tissues that result in ... Systemic Diseases or conditions affecting the periodontal supporting tissues. Periodontal Abscesses and Endodontic-Periodontal ... when periodontal pocket is involved. It can assist in periodontal healing and reduce periodontal pocketing by changing the ...
Periodontal ligaments[edit]. The periodontal ligament is a specialized connective tissue that attaches the cementum of a tooth ... Each ligament has a width of 0.15-0.38mm, but this size decreases over time.[32] The functions of the periodontal ligaments ... periodontal ligaments, alveolar bone, and gingiva. Of these, cementum is the only one that is a part of a tooth. Periodontal ... The principal role of cementum is to serve as a medium by which the periodontal ligaments can attach to the tooth for stability ...
Periodontal ligament :23. Alveolar bone 24. Vessels and nerves: :25. dental :26. periodontal :27. alveolar through channel ... Thus it represents the junction of the pulp and the periodontal tissue. ...
Injection methodology: The periodontal ligament space provides an accessible route to the cancellous alveolar bone, and the ... D'Souza JE, Walton RE, Peterson LC (March 1987). "Periodontal ligament injection: an evaluation of the extent of anesthesia and ... Walton RE, Abbott BJ (October 1981). "Periodontal ligament injection: a clinical evaluation". Journal of the American Dental ... Smith GN, Walton RE, Abbott BJ (December 1983). "Clinical evaluation of periodontal ligament anesthesia using a pressure ...
ISBN 978-0-415-30666-9. Zarb, George A.; Albrektsson, Tomas (1991). "Osseointegration: A requiem for the periodontal ligament ... No scar tissue, cartilage or ligament fibers are present between the bone and implant surface. The direct contact of bone and ...
Widened periodontal ligament (PDL) space is visible. For most situations urgent treatment is required to eliminate the pain and ...
In the teeth, Sharpey's fibres are the terminal ends of principal fibres (of the periodontal ligament) that insert into the ... "C. Principal fibers of the periodontal ligament". Archived from the original on 2 September 2006. Kuroiwa, M; Chihara K; ... suggests that the three-dimensional structure of Sharpey's fibres intensifies the continuity between the periodontal ligament ...
Andreasen JO, Kristerson L (2009). "The effect of limited drying or removal of the periodontal ligament. Periodontal healing ... a tooth is connected to the socket by means of the periodontal ligament. When a tooth is knocked out, that ligament stretches ... showed that the key to retention of the knocked-out teeth was to maintain the vitality of the periodontal ligament. In 1980, ... These include: The extent of damage to the periodontal ligament (PDL) at the time of injury The storage conditions of the ...
August 2006). "Stem cell properties of human periodontal ligament cells". Journal of Periodontal Research. 41 (4): 303-10. doi: ...
Bone deposition occurs in the distracted periodontal ligament. Without bone deposition, the tooth will loosen, and voids will ... which occurs when the periodontal ligament has been subjected to an excessive amount and duration of compressive stress. ... the periodontal membrane stretches on one side and is compressed on the other. This movement needs to be done slowly or ...
The periodontal ligament: A unique, multifunctional, connective tissue. Perio 2000 1997;13:20-40. Sculean A, et al. The ... The presence of acellular cementum acts to signal the development of periodontal ligament fibers, followed by new alveolar bone ... But it has been demonstrated that EMD serves to promote periodontal ligament fibroblast proliferation and growth and inhibit ... Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative. J Clin Perio 2001;28:181-8. ...
Some rests become calcified in the periodontal ligament (cementicles). ERM plays a role in cementum repair and regeneration. ... are part of the periodontal ligament cells around a tooth. They are discrete clusters of residual cells from Hertwig's ... maintenance and regeneration of periodontal ligament tissues". Periodontol 2000. 63 (1): 217-33. doi:10.1111/prd.12023. PMID ... Rincon JC, Young WG, Bartold PM (2006). "The epithelial cell rests of Malassez--a role in periodontal regeneration?". J ...
In periodontal ligaments mediating the teeth connection to the jaw bones, Tnmd contributes to proper fibroblast adhesion. - In ... Protein analyses in eye and periodontal ligament revealed full length TNMD protein as a double band of 40 and 45 kDa. It has ... Mouse periodontal ligaments demonstrated tenomodulin protein expression at 3 and 4 weeks postnatal, a time period corresponding ... "Tenomodulin expression in the periodontal ligament enhances cellular adhesion". PLOS ONE. 8 (4): e60203. doi:10.1371/journal. ...
Rejuvenation and development of the periodontal ligament have been taken as a factor in the eruption of the tooth due to the ... The case is not the same where the existence of a periodontal ligament does not always correspond with resorption in teeth that ... Cases do however happen in which rootless teeth erupt and when a periodontal ligament is present, and the tooth does not erupt ... The presence of stem cells in the dental is an integral part of the DF's ability to differentiate into the periodontal ligament ...
"Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene". Gene. 275 ... "Regulation of PLAP-1 expression in periodontal ligament cells". Journal of Dental Research. 85 (5): 447-51. doi:10.1177/ ...
Head of Latvian Part of Project). Development of a Nonlinear Numerical Constitutive Model for the Periodontal Ligaments. NATO ...
There is no communication of the lesion with periodontal ligament (PDL). Class IIIa - Complete invagination. It extends through ...
Damage to the periodontal ligament can lead to RANKL release activating osteoclasts. Osteoclasts in close proximity to the root ... It is commonly caused by damage to the periodontal ligament (PDL), drying of root surface following avulsion, exposure of ... doi:10.1034/j.1601-1546.2002.10106.x. Andreasen JO (1981). "Relationship between cell damage in the periodontal ligament after ... These cause damage to the periodontal ligament (PDL), cementum, or pre-dentine. These tissues provide protection from ...
Apical periodontitis is acute inflammation of the periodontal ligament surrounding the tooth. This can be caused by ... A periodontal abscess is a localised inflammation affecting the periodontal tissues. It is caused by bacteria pre-existing in a ... apical abscess may drain through the periodontal pocket giving a false interpretation of periodontal abscess or a periodontal ... It can happen due to periodontal problems, infection, abscess, cysts, allergic reaction (anaphylactic shock), salivary gland ...
Holliday, Richard S; Campbell, James; Preshaw, Philip M. (2019). "Effect of nicotine on human gingival, periodontal ligament ...
Holliday RS, Campbell J, Preshaw PM (July 2019). "Effect of nicotine on human gingival, periodontal ligament and oral ...
The periodontal ligament in itself is an area of high turnover that allows the tooth not only to be suspended in the alveolar ... The periodontal ligament depends on stimulation provided by function to preserve its structure. Within physiologic limits the ... It consists of four principal components, namely: Gingiva Periodontal ligament (PDL) Cementum Alveolar bone proper Each of ... Mitsiadis TA, Pagella P, Cantù C (2017). "Early Determination of the Periodontal Domain by the Wnt-Antagonist Frzb/Sfrp3". ...
Feasibility study about finite element simulation of the dental periodontal ligament in vivo. Journal of Medical Biomechanics, ...
Mechanical force may increase the expression of MMP1 in human periodontal ligament cells. MMP1 has been shown to interact with ... promoter on force-induced MMP-1 expression in human periodontal ligament cells". Eur. J. Oral Sci. 116 (4): 319-23. doi:10.1111 ...
The fibrous connection between a tooth and its socket is a periodontal ligament. Specifically, the connection is made between ... A grade III injury is a complete anteroinferior tibiofibular ligament tear including a (partial) interosseous ligament tear and ... Grade II injury is a complete anteroinferior tibiofibular ligament and inferior interosseous ligament tear, meaning that ... A grade I injury is a partial anteroinferior tibiofibular ligament tear, meaning the exorotation and squeeze tests are negative ...
Kitagawa M, Kudo Y, Iizuka S (2006). "Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells ...
The apical periodontal ligament (PDL) space widens and becomes continuous with apical radiolucency; the lamina dura of the ... Furthermore, if the tooth is severely damaged, it could lead to inflammation of the apical periodontal ligament, and ...
This is because the tooth is not fused to the bones of the jaws, but is connected to the sockets by the periodontal ligament. ... Generally, the degree of mobility is inversely related to the amount of bone and periodontal ligament support left. Grace & ... Abnormal, pathologic tooth mobility occurs when the attachment of the periodontal ligament to the tooth is reduced (attachment ... Periodontal disease is caused by inflammation of the gums and the supporting tissue due to dental plaque. Periodontal disease ...
"Regulation of PLAP-1 expression in periodontal ligament cells". Journal of Dental Research. 85 (5): 447-51. PMID 16632759. doi: ... "Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene". Gene. 275 ...
... refers to trauma (injury) to the teeth and/or periodontium (gums, periodontal ligament, alveolar bone), and ... When the injured teeth are painful while functioning due to damage to the periodontal ligaments (e.g., dental subluxation), a ... Gingivae bleeding especially around the margins may suggest injury to the periodontal ligament of the tooth. ...
Fibroblasts develop the periodontal ligaments which connect teeth to the alveolar bone through cementum.[4] ... into the gingiva immediately apical to the junctional epithelial attachment and the periodontal ligament fibers (I), (J) and (K ...
Periodontal ligament. Glands. *Parotid gland *duct. *Submandibular gland *duct. *Sublingual gland *duct ...
I, alveolar crest fibers of the periodontal ligament (PDL). J, horizontal fibers of the PDL. K, oblique fibers of the PDL. ... The col may be important in the formation of periodontal disease but is visible clinically only when teeth are extracted.[2] ... When gum tissue is not healthy, it can provide a gateway for periodontal disease to advance into the deeper tissue of the ... Thus when healthy, it presents an effective barrier to the barrage of periodontal insults to deeper tissue. Healthy gums are ...
It is attached to the alveolar bone (C) by the fibers of the periodontal ligament and to the soft tissue of the gingiva by the ... The cementum is the part of the periodontium that attaches the teeth to the alveolar bone by anchoring the periodontal ligament ... Sharpey fibers are part of the principal collagenous fibers of the periodontal ligament embedded in the cementum and alveolar ... Instead, the canals are oriented toward the periodontal ligament and contain cementocytic processes that exist to diffuse ...
Periodontium (gingiva, periodontal ligament, cementum, alveolus) - Gums and tooth-supporting structures. *Cementicle ...
Periodontium (gingiva, periodontal ligament, cementum, alveolus) - Gums and tooth-supporting structures. *Cementicle ...
... and periodontal ligaments when used with the LANAP protocol.[13] Benefits of laser gum disease surgery[edit]. According to the ... The Nd:YAG laser has been shown to reduce levels of microbial pathogens in periodontal pockets[4] and vaporize the pocket- ... The use of lasers in treating periodontal disease has been seen by some dental professionals as controversial.[7] The American ... Kao RT, Nares S, Reynolds MA (Feb 2015). "Periodontal regeneration - Intrabony defects: A systematic review from the AAP ...
Periodontium (gingiva, periodontal ligament, cementum, alveolus) - Gums and tooth-supporting structures. *Cementicle ... Mechanical-tactile - dental probe during dental examination,[8] periodontal scaling and root planing,[8] toothbrushing.[7] ... and periodontal root planing.[9] Dental bleaching is another known cause of hypersensitivity.[8] Other causes include smoking ... especially in areas of periodontal attachment loss.[9] ...
... perivascular niche of dental pulp and periodontal ligament).[24] MSCs are attractive for clinical therapy due to their ability ...
periodontal abscess with lymph node enlargement. Radiographic Features[edit]. Radiographically, the periodontal lesion often ... It is essential that all patients undergo a routine periodontal examination to screen for any form of periodontal disease ... Armitage, Gary C. (2004). "Periodontal diagnoses and classification of periodontal diseases". Periodontology 2000. 34: 9-21. ... to halt further periodontal destruction and regain as much periodontal attachment as possible. The objective of treatment is to ...
Periodontium: Cementum · Pidû · Periodontal ligament. Toşpiyan. Parotid gland/Parotid duct · Submandibular gland/Submandibular ...
During mastication (chewing), the resultant compression forces acting on the periodontal ligament cause the stimulated release ...
... s are found in the skin, lungs, arteries, veins, connective tissue proper, elastic cartilage, periodontal ligament ...
Periodontium (gingiva, periodontal ligament, cementum, alveolus) - Gums and tooth-supporting structures. *Cementicle ...
Periodontium (gingiva, periodontal ligament, cementum, alveolus) - Gums and tooth-supporting structures. *Cementicle ...
"Periodontal ligament, cementum, and alveolar bone in the oldest herbivorous tetrapods, and their evolutionary significance". ...
... periodontal ligament and alveolar ligament. Progression of the disease into tissue beyond the mucogingival junction ... Periodontal pocket formation Gingival ulceration and suppuration Destruction of the alveolar bone and periodontal ligament ... Features of the Advanced Lesion: Extension of the lesion into alveolar bone, periodontal ligament with significant bone loss ... A periodontal abscess involves a greater dimension of the gum tissue, extending apically and adjacent to a periodontal pocket. ...
... of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament ...
Periodontal ligament. *Sulcular epithelium. *Stippling. Disease. Diagnoses. *Chronic periodontitis. *Localized aggressive ...
Periodontium (gingiva, periodontal ligament, cementum, alveolus) - Gums and tooth-supporting structures. *Cementicle ... periodontal scaling and root planing are considered as a treatment for periodontal disease, not as a preventive treatment for ... A dental hygienist or dentist will also look for signs of periodontitis using X-rays or periodontal probing as well as other ... The comprehensive periodontal exam consists of a visual exam, a series of radiographs, probing of the gingiva, determining the ...
Periodontium (gingiva, periodontal ligament, cementum, alveolus) - Gums and tooth-supporting structures. *Cementicle ...
Periodontium (gingiva, periodontal ligament, cementum, alveolus) - Gums and tooth-supporting structures. *Cementicle ... Eagle syndrome occurs due to elongation of the styloid process or calcification of the stylohyoid ligament. However, the cause ... Anteroposterior and lateral radiographs of cervical spine showing ossification of the stylohyoid ligament on both sides. ... CT scan, coronal section showing bilateral extended styloid process and stylohyoid ligament ossification (incidental finding) ...
Periodontium (gingiva, periodontal ligament, cementum, alveolus) - Gums and tooth-supporting structures. *Cementicle ...
This may localize all the force of the bite onto one tooth, and cause inflammation of the periodontal ligament and reversible ... The ligament directly associated with the TMJ is the temporomandibular ligament, also termed the lateral ligament, which really ... The stylomandibular ligament and the sphenomandibular ligament are not directly associated with the joint capsule. Together, ... ligaments, bones, connective tissue, or the teeth.[22] TMJ dysfunction is commonly associated with symptoms affecting cervical ...
"Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults". Cochrane Database of ...
Periodontium (gingiva, periodontal ligament, cementum, alveolus) - Gums and tooth-supporting structures. *Cementicle ...
Periodontal ligament definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look ... periodontal ligament. n.. *The connective tissue surrounding the root of a tooth and attaching it to its bony socket. ...
periodontal ligament nerve synonyms, periodontal ligament nerve pronunciation, periodontal ligament nerve translation, English ... dictionary definition of periodontal ligament nerve. n. 1. Any of the cordlike bundles of fibers made up of neurons through ... Periodontal ligament nerve - definition of periodontal ligament nerve by The Free Dictionary https://www.thefreedictionary.com/ ... redirected from periodontal ligament nerve). Also found in: Thesaurus, Medical, Encyclopedia. nerve. (nûrv). n.. 1. Any of the ...
Streptococcus gordonii lipoproteins induce IL-8 in human periodontal ligament cells.. Kim AR1, Ahn KB2, Kim HY1, Seo HS3, Kum ... Apical periodontitis; Human periodontal ligament cells; IL-8; Lipoprotein; Streptococcus gordonii; TLR2 ... 8 induction in human periodontal ligament (PDL) cells using ethanol-inactivated wild-type S. gordonii, a lipoteichoic acid (LTA ...
The periodontal ligament (PDL) is an important structure that is composed of periodontal tissue, in which PDL cells generate ... "Analysis of gene expression during mineralization of cultured human periodontal ligament cells," Journal of Periodontal and ... Periodontal ligament tissues were dissected into small pieces from the midportion of the root with a sharp blade. The pieces ... Human periodontal ligament (PDL) cells obtained from extracted teeth are a potential cell source for tissue engineering. We ...
Regeneration of periodontal tissues, lost as a result of periodontal disease, is a key objective of periodontal treatment. ... Potential of Periodontal Ligament Cells to Regenerate Alveolar Bone * * HOSOYA Akihiro * Department of Oral Histology, ... Formation of bone-like mineralized matrix by periodontal ligament cells in vivo : a morphological study in rats HIRAGA Toru , ... Thus, periodontal ligament cells might be useful for the regeneration of alveolar bone in tissue engineering applications. ...
... Journal. Journal of Periodontal Research. Volume , ... Periodontal ligament fibroblasts may be considered to play an important role in the remodelling of alveolar bone. In vitro ... Periodontal ligament fibroblasts have the capacity to select and attract osteoclast precursors and subsequently to retract and ... Incubation of periodontal ligament fibroblasts with bacteria or bacterial components causes an increased expression of RANKL ...
... L. Feller,1 R. A ... "Cytokine expression pattern in compression and tension sides of the periodontal ligament during orthodontic tooth movement in ... L. Feller and J. Lemmer, "Tooth mobility after periodontal surgery," Journal of the South African Dental Association, vol. 59, ... A. Miyagawa, M. Chiba, H. Hayashi, and K. Igarashi, "Compressive force induces VEGF production in periodontal tissues," Journal ...
The Longitudinal Effectiveness of Osseointegrated Dental Implants. The Toronto Study: Bone Level Changes. Chaytor, Douglas V.; Zarb, George A.; Schmitt, Adrianne; Lewis, Donald W. // International Journal of Periodontics & Restorative Dentistry;1991, Vol. 11 Issue 2, p112 The articdle presents information on a study which investigated bone level changes determined from periapical radiographs made at annual recall visits of patients for up to nine years after implant placement. A brief overview is given on alveolar bone loss. It also discusses the importance of... ...
... which contribute to the pathogenesis of periodontal disease, in human periodontal ligament cells (HPDLC). The production levels ... Shikonin Inhibits Inflammatory Cytokine Production in Human Periodontal Ligament Cells * * Shindo Satoru ... These findings suggest that shikonin could have direct beneficial effects against periodontal disease by reducing IL-6, IL-8, ...
... periodontal ligament stem cells, periodontal regeneration, cell sheets ... the effects of nanotopography on the functions of periodontal ligament (PDL) stem cells (PDLSCs) and on PDLSC sheet based ... The Ti/cell sheets/HA complex may constitute a good model to predict the effect of biomaterials on periodontal regeneration. ... Simultaneously, the NTs improved the periodontal regeneration result of the ectopically implanted Ti/cell sheets/HA complex, ...
Generation of Fibrodysplasia ossificans progressiva and control integration free iPSC lines from periodontal ligament ... line derived from periodontal ligament fibroblast cells using Sendai virus vectors.. Copyright © 2019 The Authors. Published by ...
27 Bone, Periodontal Ligament, and Stem Cell Biology Thursday, March 22, 2012: 8 a.m.-9:30 a.m. ... To appreciate the genetic factors that are important for periodontal ligament remodeling.. To appreciate the genetic factors ...
Periodontal ligament space, ligamento periodontal upla parte 1, Periodontal ligament, Fibras del ligamento periodontal - ... Periodontal ligament. Periodontal ligament. What is periodontal ligament? Keywords: Periodontal ligament Periodontics Sharpeys ... Espacio del ligamento periodontal. Periodontal ligament space. Espacio del ligamento periodontal. Periodontal ligament space. * ... Espacio del ligamento periodontal. Periodontal ligament space. Espacio del ligamento periodontal. Periodontal ligament space. ...
What is periodontal ligament? Meaning of periodontal ligament medical term. What does periodontal ligament mean? ... Looking for online definition of periodontal ligament in the Medical Dictionary? periodontal ligament explanation free. ... Related to periodontal ligament: periodontal ligament fibers ligament. [lig´ah-ment] 1. a band of fibrous tissue connecting ... ventricular ligament vestibular ligament.. vesicouterine ligament a ligament that extends from the anterior aspect of the ...
The aim of this study was to clarify the effect of IL-35 on IL-6 and IL-8 production in human periodontal ligament cells ( ... IL-17 regulates the expressions of RANKL and OPG in human periodontal ligament cells via TRAF6/TBK1-JNK/NF-κB pathways. ... Genipin inhibits IL-1β-induced CCL20 and IL-6 production from human periodontal ligament cells. Cellular Physiology and ... The effect of IL-17 on the production of proinflammatory cytokines and matrix metalloproteinase-1 by human periodontal ligament ...
An abstract of the article "Sonic Hedgehog Stimulates Proliferation of Human Periodontal Ligament Stem Cells," by C. Martinez, ...
... but the effect of this composite scaffold on the viability and differentiation of periodontal ligament stem cells (PDLSCs) and ... periodontal ligament, stem cells, hydroxyapatite, chitosan, scaffold, tissue engineering ... Bone repair by periodontal ligament stem cell-seeded nanohydroxyapatite-chitosan scaffold Shaohua Ge,1 Ning Zhao,1 Lu Wang,1 ... but the effect of this composite scaffold on the viability and differentiation of periodontal ligament stem cells (PDLSCs) and ...
Andreasen JO, Kristerson L: The effect of limited drying or removal of the periodontal ligament. Periodontal healing after ... Key Words: incisor replantation, sodium fluoride, periodontal ligament. Introduction The study of the biological response after ... The advantages and disadvantages of maintaining the periodontal ligament (PDL) in immediate replantation as well as chemical ... Effects of Tooth Immersion in Sodium Fluoride and Subsequent Removal of the Periodontal Ligament Tetuo OKAMOTO1 Walter NICCOLI- ...
Y. Zhang, X. Li, Lipopolysaccharide-regulated production of bone sialoprotein and interleukin-8 in human periodontal ligament ... and nicotine-stimulated human periodontal ligament cells (hPDLCs). The H2S donor, NaHS, protected hPDLCs from nicotine and LPS- ... Role of resistin in the inflammatory response induced by nicotine plus lipopolysaccharide in human periodontal ligament cellsin ... Anti-inflammatory and anti-osteoclastogenic effects of zinc finger protein A20 overexpression in human periodontal ligament ...
List the indications for periodontal ligament injections.. *Recognize the advantages and disadvantages of periodontal ligament ... Identify the contraindications to periodontal ligament injections.. *Discuss the duration and efficacy of periodontal ligament ... The indications and contraindications for periodontal ligament injections are discussed in addition to factors influencing the ... This basic-level course describes periodontal ligament injection techniques for administering local anesthetics to provide ...
Human periodontal ligament stem cells (PDLSCs), derived from the periodontium, have stem cell properties similar to those of ... Macrophages play a critical role in periodontal disease, but little is known regarding the role of PDLSCs in macrophage ... In 2004, periodontal ligament stem cells (PDLSCs) were isolated from the human periodontal ligament [9]. They had the capacity ... Conditioned Medium from Periodontal Ligament Stem Cells Enhances Periodontal Regeneration. Tissue Eng. Part A 2017, 23, 367-377 ...
The relationship between tooth roots and diet is relatively unexplored, although a logical relationship between harder diets and increased root surface area is suggested. Two studies were done to address the interaction between tooth root morphology, diet and bite force in small mammals. In bats there was a clear relationship between food hardness and root surface area. In contrast, no strong relationship was found between estimated bite force and tooth root surface area in rodents. In general though, these studies combined show that microCT successfully allows the non-destructive quantification of previously difficult-to-access tooth morphology and shows the potential for tooth roots to provide valuable dietary, behavioral and ecological information in small mammals. The study of root morphology by microCT inevitably ignores the PDL fibrous component, yet this is also critical for mechanical behavior. Therefore, simplified single-rooted tooth geometry was used to make predictions about PDL ...
Specifically, this work examines the effects of the alveoli (tooth sockets), periodontal ligament, and squamosal suture on the ... Specifically, this work examines the effects of the alveoli (tooth sockets), periodontal ligament, and squamosal suture on the ... Assessing the Biomechanical Effect of Alveoli, Periodontal Ligaments, and Squamosal Sutures in Mammalian Crania ...
... periodontal,ligament,stem,cells,isolated,for,the,first,time,biological,biology news articles,biology news today,latest biology ... to regenerate the periodontal ligament, a common target of advanced gum (periodontal) disease. This enthusiasm is based on ... Shi said scientists have suspected since the 1970s that the periodontal ligament might contain its own unique stem cells. But, ... and their colleagues have isolated human postnatal stem cells for the first time directly from the periodontal ligament, the ...
Application of periodontal ligament cell sheet for periodontal regeneration: A pilot study in beagle dogs. J Periodontal Res. ... Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model. Biomaterials. 30:2716- ... Next, the periodontal ligament tissue was scraped from the teeth and shattered on a super-clean table using a mixture of 3 mg/ ... cPDLSCs, canine periodontal ligament stem cells; ALP, alkaline phosphatase; BMP2, bone morphogenetic protein 2; COL1, collagen ...
Clinical and histochemical alterations of the periodontal ligament in gerbils after malocclusion induced/Alteraciones clinicas ... e histoquimicas del ligamento periodontal en gerbiles despues de maloclusion inducida. by International Journal of Morphology ... ligament+in...-a0187327543. *APA style: Clinical and histochemical alterations of the periodontal ligament in gerbils after ... The periodontal ligament is the connective tissue localized between the root of the tooth and the alveolar bone, and is known ...
... periodontal ligament stem cells, osteogenic differentiation, periodontal regeneration, periodontal tissue engineering ... Cellular responses of periodontal ligament stem cells to a novel synthesized form of calcium hydrogen phosphate with a ... and osteogenic differentiation of periodontal ligament stem cells (PDLSCs) on a CHP-HA substrate in comparison with ... We propose that CHP-HA may be a promising alternative biomaterial for periodontal tissue engineering. ...
... osteogenic and angiogenic markers involved in bone differentiation of human periodontal ligament stem cells (hPDLSCs) on ... osteogenic and angiogenic markers involved in bone differentiation of human periodontal ligament stem cells on different ... In vitro periodontal ligament cell expansion by co-culture method and formation of multi-layered periodontal ligament-derived ... Influence of nanotopography on periodontal ligament stem cell functions and cell sheet based periodontal regeneration. Int. J. ...
What is fibrous, of periodontal ligament matrix? Meaning of fibrous, of periodontal ligament matrix as a finance term. What ... does fibrous, of periodontal ligament matrix mean in finance? ... of periodontal ligament matrix in the Financial Dictionary - by ... Fibrous, of periodontal ligament matrix financial definition of fibrous, of periodontal ligament matrix https://financial- ... redirected from fibrous, of periodontal ligament matrix). Also found in: Dictionary, Thesaurus, Medical, Legal, Encyclopedia. ...
In addition, similar results were observed in periodontal ligaments (Fig. 1D), which indicated that periodontal ligaments ... Periodontal ligament stem cells (PDLSCs) are a class of odontogenic MSCs residing in periodontal ligament with functions of ... vascularization of periodontal ligaments was also enhanced in periodontitis, suggesting that periodontal ligaments shared ... but angiogenic changes of periodontal ligaments under inflammatory condition were rarely reported. Periodontal ligament stem ...
  • This complex structure of PDL tissue comprises several different cell populations [ 3 ], including PDL cells, which are predominantly fibroblasts and play crucial roles in maintaining and regenerating periodontal tissue [ 2 , 3 ]. (hindawi.com)
  • Furthermore, human induced pluripotent stem cells (iPS cells) have been generated from adult human periodontal ligament fibroblasts [ 7 ]. (hindawi.com)
  • During the last decade it has become clear that periodontal ligament fibroblasts may contribute to the in vitro differentiation of osteoclasts. (uva.nl)
  • Periodontal ligament fibroblasts have the capacity to select and attract osteoclast precursors and subsequently to retract and enable migration of osteoclast precursors to the bone surface. (uva.nl)
  • Periodontal ligament fibroblasts produce primarily OPG, an osteoclastogenesis-inhibitory molecule. (uva.nl)
  • Incubation of periodontal ligament fibroblasts with bacteria or bacterial components causes an increased expression of RANKL and other osteoclastogenesis-stimulating molecules, such as tumor necrosis factor-α and macrophage-colony stimulating factor. (uva.nl)
  • Periodontal ligament fibroblasts may be considered to play an important role in the remodelling of alveolar bone. (uva.nl)
  • In vitro experiments have demonstrated that periodontal ligament fibroblasts adapt to bacterial and mechanical stimuli by synthesizing higher levels of osteoclastogenesis-stimulating molecules. (uva.nl)
  • Generation of Fibrodysplasia ossificans progressiva and control integration free iPSC lines from periodontal ligament fibroblasts. (nih.gov)
  • Solitary cilia occur in motile as well as in non-motile fibroblasts of the periodontal ligament. (springer.com)
  • Beertsen, W.: Migration of fibroblasts in the periodontal ligament of the mouse incisor as revealed by autoradiography. (springer.com)
  • 2014. The effect of IL-17 on the production of proinflammatory cytokines and matrix metalloproteinase-1 by human periodontal ligament fibroblasts. (springer.com)
  • OBJECTIVE To compare the mechanotransduction caused by cyclic and static mechanical strains in human periodontal ligament fibroblasts (hPDLFs) cultured under identical conditions. (uzh.ch)
  • The aim of our study was to evaluate the effect of active vitamin D3 (VD) on the expression of pro-inflammatory and anti-inflammatory cytokines (IL-6, IL-8, IL-10 and IL-12) in human gingival fibroblasts (hGF) and human periodontal ligament cells (hPDLc) triggered by Porphyromonas gingivalis and Streptococcus pyogenes. (minervamedica.it)
  • Nastri L, Guida L, Annunziata M, Ruggiero N, Rizzo A. Vitamin D modulatory effect on cytokines expression by human gingival fibroblasts and periodontal ligament cells. (minervamedica.it)
  • 5. The peptide of claim 1, wherein the peptide promotes the proliferation of periodontal ligament fibroblasts. (patents.com)
  • Since MPLF cells have the capacity for vigorous contraction of the collagen gels and since they develop a reticular, 3-dimensional structure in compacted gels that is reminiscent of the relationship of periodontal ligament fibroblasts to collagen fibres in vivo, it is suggested that they could provide the major force necessary for tooth eruption in vivo. (biologists.org)
  • In this research project, we have focuesed on the cell growth and differentiation, and cell attachment and spreading factors (CASFs) of the fibroblasts derived from human periodontal ligaments of first premolars as descrived by Kawase, T et al (1988). (nii.ac.jp)
  • Publications] Yasu N.: 'Effect of cyclic mechanical stress on attachment and spreading of human periodontal ligament fibroblasts' Bull of Kanagawa Dent Col.20(1). (nii.ac.jp)
  • Publications] Kawase T.: 'Culture of fibroblasts derived from the dental follicle deciduous and permanant periodontal ligament' Bull of Kanagawa Dent.Col.20(2). (nii.ac.jp)
  • Publications] Kubo,Shigeki et al: 'Cell attachment and spreading factors of human periodontal ligament fibroblasts(HPLF). (nii.ac.jp)
  • During orthodontic tooth movement (OTM) mechanical forces trigger pseudo-inflammatory, osteoclastogenic and remodelling processes in the periodontal ligament (PDL) that are mediated by PDL fibroblasts via the expression of various signalling molecules. (uni-regensburg.de)
  • Recent studies have suggested multiple functions of periodontal ligament fibroblasts (PDLFs) which may relate to the permeability of gap junctions composed of various types of connexins (Cxs). (elsevier.com)
  • Journal of Periodontal Research 47 (2) : 212-221. (nus.edu.sg)
  • Journal of Periodontal Research , 19 (3), 238-246. (elsevier.com)
  • Journal of Periodontal Research , 49 (2), 260-267. (elsevier.com)
  • They are involved in adult regeneration of the periodontal ligament, alveolar bone, and cementum. (wikipedia.org)
  • Therefore, much research is being conducted on periodontal tissue regeneration for restoring the alveolar support of the teeth. (hindawi.com)
  • The periodontal ligament (PDL) is an important structure that is composed of periodontal tissue, in which PDL cells generate connective tissue fibers that span the gap between the cementum and the alveolar bone [ 2 ] to suspend the tooth. (hindawi.com)
  • Therefore, in the present study, to clarify the existence of osteoblast progenitor cells in the periodontal ligament, as well as to investigate the mechanism of alveolar bone regeneration without any effects from the original bone, we evaluated osteoblast differentiation induced by transplantation of GFP-transgenic rat molars into the subcutaneous tissues of wild-type rats. (nii.ac.jp)
  • These results indicate that periodontal ligament tissue remaining on the root surface after a tooth extraction contains undifferentiated cells that have the ability to regenerate alveolar bone. (nii.ac.jp)
  • Thus, periodontal ligament cells might be useful for the regeneration of alveolar bone in tissue engineering applications. (nii.ac.jp)
  • The disease manifests as gingival swelling and bleeding, increased periodontal pocket depth, and alveolar bone loss. (mdpi.com)
  • Effect of cyclical forces on the periodontal ligament and alveolar bone remodeling during orthodontic tooth movement. (medworm.com)
  • Periodontitis is identified as a chronic bacterial infectious disease, which invades the tooth-supporting tissues, such as gingiva, periodontal ligaments and alveolar bone [ 1 ]. (medsci.org)
  • Periodontal ligament locates in the gap between tooth root and alveolar bone to fasten the tooth, which is often invaded and destructed by inflammation when chronic periodontitis was extending [ 7 ]. (medsci.org)
  • Tri-Layered Nanocomposite Hydrogel Scaffold for the Concurrent Regeneration of Cementum, Periodontal Ligament, and Alveolar Bone. (amrita.edu)
  • A tri-layered scaffolding approach is adopted for the complete and concurrent regeneration of hard tissues-cementum and alveolar bone-and soft tissue-the periodontal ligament (PDL)-at a periodontal defect site. (amrita.edu)
  • Periodontal diseases, periapical diseases, jaw osteomyelitis, and oral and maxillofacial tumors can cause alveolar bone tissue loss, which eventually affects chewing function ( 1 - 3 ). (spandidos-publications.com)
  • The supporting tissues are known as the periodontium , which includes the gingiva (gums), alveolar bone , cementum , and the periodontal ligament . (wikipedia.org)
  • The soft tissues and connective fibres that cover and protect the underlying cementum, periodontal ligament and alveolar bone are known as the gingivae. (wikipedia.org)
  • Although bacterially-mediated mechanisms of alveolar bone destruction have been widely studied, the effects of a polymicrobial infection on the periodontal ligament and microbiome/virome have not been well explored. (nature.com)
  • In the part of periodontal ligament adjacent to the alveolar bone, such nerve fibers left nerve bundles and formed bush-like endings, i.e., they ramified repeatedly and terminated with one to four twigs. (elsevier.com)
  • Periodontal ligaments are connective tissue which hold teeth in place by attaching them to the alveolar bone. (answers.com)
  • The spongy trabeculae of the alveolar bone are what absorb a large part of the pressure transmitted via the periodontal ligament, coming from the occlusal forces (1)(2)(4). (care4dental.com)
  • Reduction of alveolar bone height had little effect on the degree of periodontal ligament stress until six millimeters (60%) of bone support had been lost. (elsevier.com)
  • The periodontal ligament (PDL) is located between teeth and alveolar bone and plays an integral role in the maintenance and regeneration of periodontal tissue. (thno.org)
  • The periodontal ligament, commonly abbreviated as the PDL, is a group of specialized connective tissue fibers that essentially attach a tooth to the alveolar bone within which it sits. (wikipedia.org)
  • The main principal fiber group is the alveolodental ligament, which consists of five fiber subgroups: alveolar crest, horizontal, oblique, apical, and interradicular on multirooted teeth. (wikipedia.org)
  • The PDL appears as the periodontal space of 0.4 to 1.5 mm[citation needed] on radiographs, a radiolucent area between the radiopaque lamina dura of the alveolar bone proper and the radiopaque cementum. (wikipedia.org)
  • Human PDL cells obtained from extracted teeth are a promising cell source for periodontal tissue regeneration, regenerative medicine, and tissue engineering [ 3 - 6 ], because they include stem cells that have a high capacity for proliferation, self-renewal, and multilineage differentiation and also have the ability to form cementum/periodontal ligament-like tissue in vivo [ 3 , 4 ]. (hindawi.com)
  • This enthusiasm is based on follow up experiments, in which the researchers implanted the human adult stem cells into rodents, and most of the cells differentiated into a mixture of periodontal ligament -including the specific fiber bundles that attach tooth to bone - and the mineralized tissue called cementum that covers the roots of our teeth. (bio-medicine.org)
  • The structural and functional integrity of bone-periodontal ligament (PDL)-cementum complex stems from the load-bearing attachment sites (entheses) between soft (PDL) and hard (bone, cementum) tissues. (ovid.com)
  • These cryopreserved periodontal ligament stem cells maintained normal periodontal ligament stem cell characteristics, including expression of the mesenchymal stem cell surface molecule STRO-1, single-colony-strain generation, multipotential differentiation, cementum/periodontal-ligament-like tissue regeneration, and a normal diploid karyotype. (snu.ac.kr)
  • Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. (nature.com)
  • The thin acellular cementum covers the cervical portion of the tooth root and is critical for anchoring the insertion of periodontal ligament (PDL) fibers. (nature.com)
  • Oblique fibers (K) are the most numerous fibers in the periodontal ligament, running from cementum in an oblique direction to insert into bone coronally. (wikipedia.org)
  • periodontal ligament the connective tissue structure that surrounds the roots of the teeth and holds them in place in the dental alveoli. (thefreedictionary.com)
  • As a soft connective tissue, the Periodontal Ligament (PDL) exhibits material properties which are not the same at different levels. (alliedacademies.org)
  • Objectives: Recent studies have demonstrated that periodontal ligament-derived (POL) cells have the potential to regenerate a complete periodontal connective tissue attachment apparatus on both root and artificial substrates. (edu.au)
  • A joint is where two bones meet and ligament is the connective tissue that connects bone to bone. (answers.com)
  • The ligaments are a band of fibrous, slightly elastc connective tissue tt attaches bone to bone. (answers.com)
  • Ligaments are strong, flexible bands (or cords) of dense regularfibrous connective tissue that hold bones firmly together at thejoints, but are elastic enough to allow some mo … vement. (answers.com)
  • The data showed that TRAP reaction was able to evidence the osteoclastic activity in the hyperfunction hemimandible, right side, explaining the functional changes in the periodontal ligament after teeth extraction, and a little gingival recession and radicular exposure of teeth without function was observed at inferior molars of the left side. (thefreelibrary.com)
  • Los resultados mostraron que la reaccion de TRAP es capaz de evidenciar la actividad osteoclastica en la hiperfuncion de la semimandibula derecha, explicando los cambios funcionales del ligamento periodontal despues de la extraccion dental, siendo observada una pequena recesion gingival y exposicion radicular de los dientes sin funcion, en los molares inferiores izquierdos. (thefreelibrary.com)
  • Expression and intracellular localization of progesterone receptors in cultured human gingival fibroblasts'J.Periodontal Res. (nii.ac.jp)
  • Application of stem cells derived from the periodontal ligament or gingival tissue sources for tendon tissue regeneration. (semanticscholar.org)
  • A non-diseased, healthy gingival sulcus is typically 0.5-3mm in depth, however, this measurement can increase in the presence of periodontal disease. (wikipedia.org)
  • Effect of nicotine on human gingival, periodontal ligament and oral epithelial cells. (ncl.ac.uk)
  • Previous studies from the labs of Chi Pui Pang and Mingzhi Zhang (Shantou University/Chinese University of Hong Kong, PR China) described the application of mesenchymal stem cell-like cells derived from human periodontal ligament (PDLSCs) for retinal cell replacement [3, 4]. (stemcellsportal.com)
  • To evaluate the proliferative capacity of mesenchymal cells derived from human periodontal ligament on polished and plasma-treated titanium surfaces. (bvsalud.org)
  • Human periodontal ligament (PDL) cells obtained from extracted teeth are a potential cell source for tissue engineering. (hindawi.com)
  • However, for periodontal tissue regeneration, it is necessary to culture PDL cells on a biocompatible scaffold to deliver the cells to the wound site and also to provide space for the formation of the new periodontal tissue. (hindawi.com)
  • The advantages and disadvantages of maintaining the periodontal ligament (PDL) in immediate replantation as well as chemical treatment of the root surface have been a matter of discussion because the vitality of such tissue in surgery is always questioned. (usp.br)
  • Technologies that can achieve periodontal tissue regeneration and functional recovery currently remain under investigation. (spandidos-publications.com)
  • In recent years, periodontal tissue engineering has developed rapidly, providing a new direction for research. (spandidos-publications.com)
  • Periodontal tissue engineering is a technique that uses tissue engineering to construct a complex composed of one or more elements (such as cells, scaffolds and signaling molecules) for implantation into the defect area to achieve functional tissue regeneration ( 6 , 7 ). (spandidos-publications.com)
  • We propose that CHP-HA may be a promising alternative biomaterial for periodontal tissue engineering. (go.jp)
  • Effects of In Vitro Osteogenic Induction on In Vivo Tissue Regeneration by Dental Pulp and Periodontal Ligament Stem Cells. (sigmaaldrich.com)
  • The aim of this study was to determine the effects of in vitro odontogenic/cementogenic differentiation on the in vivo tissue regeneration of dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs). (sigmaaldrich.com)
  • Periodontal ligament stem cells (PDLSCs) are promising seed cells for bone tissue engineering and periodontal regeneration applications. (medscimonit.com)
  • Therefore, there is much interest in the use of periodontal tissue engineering to repair bone defects and promote bone regeneration. (spandidos-publications.com)
  • These cells have been shown to have pluripotent capacity to differentiate into osteoblasts, osteocytes and cementoblasts, and have been used in the regeneration of periodontal tissue ( 6 - 8 ). (spandidos-publications.com)
  • Therefore, hPDLSCs are a promising cell population for periodontal tissue engineering. (spandidos-publications.com)
  • A peptide, according to the present invention, promotes the growth of periodontal ligament fibroblast by means of PI3K and Akt phosphorylation and increases the expression of an activation marker such as COL1A1 and DSPP, thereby ultimately showing periodontal tissue regeneration activation. (patents.com)
  • Human periodontal ligament cells (hPDLCs) are considered the promising seed cells in periodontal tissue engineering. (ovid.com)
  • At the Academic Centre for Dentistry Amsterdam (ACTA), she has studied the regeneration of the periodontal ligament by use of tissue engineering. (myvmc.com)
  • Periodontal disease is a microbially-mediated inflammatory disease of tooth-supporting tissues that leads to bone and tissue loss around teeth. (nature.com)
  • This study was undertaken to histologically evaluate the effects of a periodontal ligament injection of local anesthetic containing various concentrations of epinephrine on pulp tissue. (nyu.edu)
  • A ligament is a tough fibrous band of tissue connecting the articular extremities of bones or supporting an organ in place. (answers.com)
  • However, no comprehensive study is currently available on the cryopreservation of periodontal ligament stem cell (PDLSC) sheets which have been suggested as excellent transplant materials for periodontal tissue regeneration. (biomedcentral.com)
  • Background and Objective: The periodontal ligament (PDL) is vital to maintaining the homeostasis of the tooth and periodontal tissue. (elsevier.com)
  • The ultimate goal of periodontal therapy is to achieve periodontal tissue regeneration, in which bone tissue regeneration is a crucial part [ 3 ]. (thno.org)
  • Periodontal ligament progenitor cells (PDLPs), with stem-cell-like properties, exhibit great potential for repair periodontal tissue including the formation of new bone [ 5 , 6 ]. (thno.org)
  • An abstract of the article "Sonic Hedgehog Stimulates Proliferation of Human Periodontal Ligament Stem Cells," by C. Martinez, P. C. Smith, J.P. Rodriguez and V. Palma, is presented. (ebscohost.com)
  • article{61880a05-c610-4f38-b4ed-a61507ffcc07, abstract = {The antimicrobial peptide LL-37 is anti-inflammatory and proapoptotic in human periodontal ligament cells. (lu.se)
  • abstract = "The human dental follicle partially differentiates into the periodontal ligament (PDL), but their biological functions are different. (elsevier.com)
  • however, the effects of nanotopography on the functions of periodontal ligament (PDL) stem cells (PDLSCs) and on PDLSC sheet based periodontal regeneration have never been explored. (dovepress.com)
  • Our study provides the first evidence that the nanotopographical cues obviously influence the functions of PDLSCs and improve the PDLSC sheet based periodontal regeneration size dependently, which provides new insight to the periodontal regeneration. (dovepress.com)
  • A nanohydroxyapatite-coated chitosan scaffold has been developed in recent years, but the effect of this composite scaffold on the viability and differentiation of periodontal ligament stem cells (PDLSCs) and bone repair is still unknown. (dovepress.com)
  • Human periodontal ligament stem cells (PDLSCs), derived from the periodontium, have stem cell properties similar to those of mesenchymal stem cells. (mdpi.com)
  • Macrophages play a critical role in periodontal disease, but little is known regarding the role of PDLSCs in macrophage modulation during inflammation. (mdpi.com)
  • The objective of the present study was to examine the cellular attachment, proliferation, and osteogenic differentiation of periodontal ligament stem cells (PDLSCs) on a CHP-HA substrate in comparison with conventional nanohydroxyapatite (NanoHA). (go.jp)
  • Periodontal ligament stem cells (PDLSCs) were a kind of dental stem cells associated with vascularization. (medsci.org)
  • Here we investigated the alteration of angiogenesis of periodontal ligament in periodontitis, and revealed an exosome-mediated pathway to support the effect of PDLSCs on angiogenic improvement. (medsci.org)
  • In conclusion, the findings indicated that vascularization of periodontal ligaments was enhanced, and inflammatory micro-environment of periodontitis facilitated pro-angiogenesis of PDLSCs through regulating exosome-mediated transfer of VEGFA, which was targeted by miR-17-5p. (medsci.org)
  • To provide insight into the biological effects of activated Yes-associated protein (YAP) on the proliferation, apoptosis, and senescence of human periodontal ligament stem cells (h-PDLSCs). (medsci.org)
  • The objective of this study was to evaluate the bone regeneration potential of IMC loaded with autologous periodontal ligament stem cells (PDLSCs) in large bone defects in minipigs. (semanticscholar.org)
  • For this purpose, adult mesenchymal stem cells (MSC), including periodontal ligament stem cells (PDLSCs), could be very useful for their differentiation capacity, easy isolation and the ability to perform an autologous implant. (qxmd.com)
  • Regeneration of periodontal tissues, lost as a result of periodontal disease, is a key objective of periodontal treatment. (nii.ac.jp)
  • Although several periodontal regeneration therapies have been devised, the origin of the undifferentiated cells that regenerate periodontal tissues remains unknown. (nii.ac.jp)
  • Anomalous vascularization is one of the most common characteristics in periodontitis leading to progressive inflammation, which results from disrupted angiogenesis in the periodontal tissues [ 3 ]. (medsci.org)
  • During the periodontal regeneration process, periodontal ligament (PDL) cells play an important role in forming new attachments between these tissues as well as cementogenesis and osteogenesis. (nii.ac.jp)
  • Effects of DMSO (Dimethyl sulfoxide) free cryopreservation with program freezing using a magnetic field on periodontal ligament cells and dental pulp tissues. (alliedacademies.org)
  • The purpose of this study was to investigate the effects of short-term cryopreservation on the root of an incomplete human tooth with periodontal ligament cells (PDL) and dental pulp tissues. (alliedacademies.org)
  • According to previous statements, this clinical study was performed with the main purpose of examining the effects of cryopreservation on human periodontal ligament cells using a magnetic field freezer and evaluating the clinical influences of cryopreservation on pulp tissues of immature and mature human teeth. (alliedacademies.org)
  • A ) IGF1 expression in periodontitis periodontal tissues compared with healthy periodontal tissues. (aging-us.com)
  • These molecular and cellular processes lead to destruction of the periodontal supporting tissues. (nature.com)
  • Nerve fibers coexpressing these calcium-binding proteins (CaBPs) were observed in the lingual periodontal ligament of incisors but not other tissues. (elsevier.com)
  • Previously, we reported the development of an effective and reliable method based on vitamin C (Vc) treatment that facilitated the construction of highly viable and functional periodontal ligament stem cell (PDLSC) sheets and the subsequent regeneration of periodontal tissues [ 9 ]. (biomedcentral.com)
  • Maxillary central incisors were modeled in periodontal tissues representing four levels of bone support. (elsevier.com)
  • The present study demonstrates that human post-natal stem cells can be recovered from cryopreserved human periodontal ligament, thereby providing a practical clinical approach for the utilization of frozen tissues for stem cell isolation. (snu.ac.kr)
  • An apparatus was developed to apply positive or negative hydrostatic pressure dynamically to periodontal ligament (PDL) cells in vitro. (nih.gov)
  • Human periodontal ligament stem cells (hPDLSCs) are a subtype of mesenchymal stem cells (MSCs) that possess multi-potency to differentiate into cells of chondrogenic, osteogenic, adipogenic and neurogenic lineages in vitro ( 4 , 5 ). (spandidos-publications.com)
  • Mechanical stress induces human periodontal ligament (PDL) cells to express an osteoblastic phenotype in vitro . (scialert.net)
  • The 3D in vitro model she has developed appears to be promising for regenerating periodontal ligament and may also prove valuable for restoring tendons and ligaments elsewhere in the body. (myvmc.com)
  • Our objective was to establish a standardized in vitro model system to investigate periodontal regenerative procedures for potential clinical application. (elsevier.com)
  • OBJECTIVE: To investigate the effect of hypoxia on isolated human periodontal ligament stem cells (hPDLSC) in vitro. (uthscsa.edu)
  • In the first clinical application of human autologous PDL-derived cells, including PDL stem cells, the transplanted cells were used to reconstruct periodontal intrabony defects in 3 patients, and a significant improvement of periodontal disease was achieved, which suggests that PDL stem cell transplantation may be an efficacious and safe alternative for the treatment of human periodontitis [ 6 ]. (hindawi.com)
  • Abnormal angiogenesis is one of the significant features in periodontitis leading to progressive inflammation, but angiogenic changes of periodontal ligaments under inflammatory condition were rarely reported. (medsci.org)
  • Vascular specific marker CD31 and VEGFA were found to be highly expressed in periodontal ligaments of periodontitis. (medsci.org)
  • Periodontal pathogens, which mainly comprised of Gram-negative anaerobic bacterial, are required to initiate periodontitis. (springer.com)
  • The infection with the pathogenic microflora, together with their virulence factors like lipopolysaccharides (LPS) and gingipain, drives the influx of neutrophils and macrophages, and activates the constituent cells, e.g. periodontal ligament cells (PDLCs), releasing a plethora of inflammatory mediators that participates in the initiation and progression of periodontitis [ 5 , 6 ]. (springer.com)
  • If left untreated, periodontitis can lead to progressive loss of the periodontal bone and subsequent tooth loss [ 2 ]. (thno.org)
  • We aimed to prepare primary cell cultures from human periodontal ligament and to identify clonogenic progenitor cells. (elsevier.com)
  • Zhang Y, Kong N, Zhang Y, Yang W, Yan F. Size-dependent Effects of Gold Nanoparticles on Osteogenic Differentiation of Human Periodontal Ligament Progenitor Cells. (thno.org)
  • Gold nanoparticles (AuNPs) have been reported to promote osteogenic differentiation of mesenchymal stem cells and osteoblasts, but little is known about their effects on human periodontal ligament progenitor cells (PDLPs). (thno.org)
  • Here, we assess anti-inflammatory properties of LL-37 and investigate the effects of LL-37 on cell differentiation, cell proliferation and apoptosis in human periodontal ligament cells. (lu.se)
  • Conclusion: LL-37 strongly attenuates lipopolysaccharide-induced cytokine and chemokine expression and, in high concentrations, reduces cell proliferation through inhibition of DNA synthesis and by promoting apoptosis in human periodontal ligament cells. (lu.se)
  • A peptide comprising an amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, according to the present invention, shows proliferation and differentiation promotion of osteoblast and proliferation and activation promotion of periodontal ligament fibroblast. (patents.com)
  • PTH/SDF-1α cotherapy promotes proliferation, migration and osteogenic differentiation of human periodontal ligament stem cells. (semanticscholar.org)
  • These findings present a novel opportunity to further investigate the differentiation and proliferation of PDL derived cells potentially capable of periodontal regeneration. (elsevier.com)
  • Mesenchymal cells were isolated from periodontal ligament of impacted third molars (n=2) and cultured on titanium disks (polished and nitrided) and on a plastic surface as a positive control of cell proliferation. (bvsalud.org)
  • We concluded that plasma nitriding produced surfaces that permitted the proliferation of human periodontal ligament mesenchymal cells. (bvsalud.org)
  • In this respect, this study evaluated the proliferation of mesenchymal cells derived from the periodontal ligament of human third molars on polished and plasma-nitrided titanium surfaces. (bvsalud.org)
  • Periodontal ligament stem cells are stem cells found near the periodontal ligament of the teeth. (wikipedia.org)
  • Scientists at the National Institute of Dental and Craniofacial Research (NIDCR), one of the National Institutes of Health, and their colleagues have isolated human postnatal stem cells for the first time directly from the periodontal ligament, the fibrous, net-like tendon that holds our teeth in their sockets. (bio-medicine.org)
  • They obtained 25 newly extracted third molars, or wisdom teeth, and gently tugged the ligament free from the root of the tooth. (bio-medicine.org)
  • SUMMARY: The aim of this article is to show the clinical and histochemical alterations of the first periodontal ligament, on the right side, after upper molars teeth extraction on the left side in gerbils. (thefreelibrary.com)
  • Material and Methods: Periodontal ligament cells were obtained from teeth extracted for orthodontic. (lu.se)
  • The clinical considerations will also be studied through this course This course will review the basic cellular composition of the teeth, the components of the periodontal apparatus, the varied components of the oral mucosa, and the histology and function of the salivary glands. (raqedu.com)
  • The periodontal ligament is the structure that surrounds the roots of the teeth and connects them to the bone in which there are held. (care4dental.com)
  • The teeth of these children were anesthetized with periodontal injection and the dental treatments were performed on each patient. (journalcra.com)
  • Periodontal ligament (PDL) cells play important roles in root resorption of human deciduous teeth by odontoclasts (osteoclast-like cells). (elsevier.com)
  • The purpose of this study was to compare the effects of virgin olive oil (VOO), soybean oil (SO), and Hank's Balanced Salt Solution (HBSS) on the vitality of periodontal ligament (PDL) cells of simulated avulsed teeth . (bvsalud.org)
  • Vegetable oils can be promising storage solutions for maintaining the periodontal ligament cell viability of avulsed teeth . (bvsalud.org)
  • The purpose of this study is to compare the properties of dental pulp and periodontal ligament stem cells from extracted supernumerary teeth by quantitative real-time PCR. (kci.go.kr)
  • Dental pulp and periodontal ligament cells were collected from extracted supernumerary teeth on the same day. (kci.go.kr)
  • Dental pulp and periodontal ligament stem cells from supernumerary teeth have the properties of odontoblasts. (kci.go.kr)
  • Considering that properties, supernumerary teeth were considered a useful donor site of dental pulp and periodontal ligament stem cells. (kci.go.kr)
  • Periodontal ligament, extra-oral period and use of fluorides in replantation of teeth. (bvsalud.org)
  • Periodontal ligament mesenchymal cells were obtained from two healthy human teeth (impacted third molars). (bvsalud.org)
  • Principal fibers other than the alveolodental ligament are the transseptal fibers. (wikipedia.org)
  • capsular ligament the fibrous layer of a joint capsule. (thefreedictionary.com)
  • Lisfranc's ligament a fibrous band extending from the medial cuneiform bone to the second metatarsal. (thefreedictionary.com)
  • meniscofemoral l's two small fibrous bands of the knee joint attached to the lateral meniscus, one (the anterior) extending to the anterior cruciate ligament and the other (the posterior) to the medial femoral condyle. (thefreedictionary.com)
  • nuchal ligament a broad, fibrous, roughly triangular sagittal septum in the back of the neck, separating the right and left sides. (thefreedictionary.com)
  • The aim of the present study was to evaluate the effect of ephrinB2 gene‑transfected canine periodontal ligament stem cells (cPDLSCs) on the regulation of osteogenic differentiation. (spandidos-publications.com)
  • The aim of the study was to evaluate the cytocompatibility, osteogenic and angiogenic markers involved in bone differentiation of human periodontal ligament stem cells (hPDLSCs) on different titanium disks surfaces. (frontiersin.org)
  • This study aims to clarify the anti-inflammatory and osteogenic effects of baicalein in periodontal ligament cells (PDLCs) treated with lipopolysaccharides (LPS). (springer.com)
  • However, how 1,25‑D3 regulates osteogenic differentiation in human periodontal ligament stem cells (hPDLSCs) remains to be fully elucidated. (spandidos-publications.com)
  • Periostin promotes migration and osteogenic differentiation of human periodontal ligament mesenchymal stem cells via the Jun amino-terminal kinases (JNK) pathway under inflammatory conditions. (qxmd.com)
  • The difference on the osteogenic differentiation between periodontal ligament stem cells and bone marrow mesenchymal stem cells under inflammatory microenviroments. (qxmd.com)
  • Hou, JX & Loomer, PM 2009, ' [Hypoxia regulates osteogenic differentiation of human periodontal ligament stem cells] ', Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology , vol. 44, no. 9, pp. 543-547. (uthscsa.edu)
  • These findings revealed that AuNPs affected the osteogenic differentiation of PDLPs in a size-dependent manner with autophagy as a potential explanation, which suggested AuNPs with defined size could be a promising material for periodontal bone regeneration. (thno.org)
  • Therefore, the development of effective strategies for promoting osteogenic differentiation of PDLPs has attracted particular attention in the field of periodontal regenerative. (thno.org)
  • Jia L, Gu W, Zhang Y, Jiang B, Qiao X, Wen Y. Activated Yes-Associated Protein Accelerates Cell Cycle, Inhibits Apoptosis, and Delays Senescence in Human Periodontal Ligament Stem Cells. (medsci.org)
  • Here we describe the generation and characterization of a control and a classical FOP induced pluripotent stem cell (iPSC) line derived from periodontal ligament fibroblast cells using Sendai virus vectors. (nih.gov)
  • Surface Chemistry of Nanoscale Mineralized Collagen Regulates Periodontal Ligament Stem Cell Fate. (semanticscholar.org)
  • For more periodontal ligament stem cell-based studies and new stem cell therapies for optic nerve injury, stay tuned to the Stem Cells Portal . (stemcellsportal.com)
  • In cases of delayed tooth replantation, non-vital periodontal ligament remnants have been removed with sodium hypochlorite in an attempt to control root resorption. (forgetmenotinitiative.org)
  • Conclusion: the treatment of root surface-adhered necrotic periodontal ligament with citric acid was not able to prevent the occurrence of ankylosis, root resorption and inflammatory resorption in delayed rat tooth replantation. (unesp.br)
  • The aim of this study was to examine whether shikonin is able to influence the production of interleukin (IL)-6, IL-8, and/or chemokine C-C motif ligand (CCL)20, which contribute to the pathogenesis of periodontal disease, in human periodontal ligament cells (HPDLC). (nii.ac.jp)
  • These findings may have significant implications for the pathogenesis of periodontal disease and biomechanical properties of the periodontium. (nature.com)
  • Document [email protected]: Viability of periodontal ligament cells after cryomicroscopy. (uhasselt.be)
  • Viability of periodontal ligament cells after cryomicroscopy. (uhasselt.be)
  • Virgin Olive Oil, Soybean Oil, and Hank's Balanced Salt Solution Used as Storage Media on Periodontal Ligament Cell Viability. (bvsalud.org)
  • Trauma or inflammation can cause destruction of the periodontal ligament. (myvmc.com)
  • Conclusion: Results showed that periodontal ligament injection can be used as an alternative to infiltration in maxillary primary molars. (journalcra.com)
  • A periodontist is a dentist that specializes in the prevention, diagnosis and treatment of periodontal disease and in the placement of dental implants. (wikipedia.org)
  • incisor replantation, sodium fluoride, periodontal ligament. (usp.br)
  • Analysis of quantitative gene expression data using relative quantification showed that the expression of all genes decreased in periodontal ligament cells. (kci.go.kr)
  • Effect of cytokines on osteoclast formation and bone resorption during mechanical force loading of the periodontal membrane," The Scientific World Journal , vol. 2014, Article ID 617032, 7 pages, 2014. (hindawi.com)
  • The following observations were made: (1) fluid was squeezed out and pumped into the ligament during the compressive and tensile loading phases, (2) the PDL was highly compressible, and (3) the pore pressure had no influence on the mechanical response of the PDL. (asme.org)
  • Thus far, it is unknown whether these processes are mainly induced by mechanical cellular deformation (mechanotransduction) or by concomitant hypoxic conditions via the compression of periodontal blood vessels. (uni-regensburg.de)
  • Mechanical stresses in the periodontal ligament which help initiate the lesion of occlusal trauma have been difficult to evaluate. (elsevier.com)
  • The scientists also say these cells have "tremendous potential" to regenerate the periodontal ligament, a common target of advanced gum (periodontal) disease. (bio-medicine.org)
  • In conclusion, the tri-layered nanocomposite hydrogel scaffold with growth factors can serve as an alternative regenerative approach to achieve simultaneous and complete periodontal regeneration. (amrita.edu)
  • The purpose of this study was to use a mathematical system (finite element analysis) to calculate principal periodontal ligament stresses in primary and secondary occlusal trauma. (elsevier.com)
  • Simultaneously, the NTs improved the periodontal regeneration result of the ectopically implanted Ti/cell sheets/HA complex, giving rise to functionally aligned collagen fiber bundles. (dovepress.com)
  • Berendsen developed a new 3D model in which cells isolated from periodontal ligament were implanted in a collagen network suspended between an artificial root and artificial bone. (myvmc.com)
  • Consequently, it could be speculated that vitamin D assessment, and its possible implementation in deficiency cases, could play a role in periodontal treatment. (minervamedica.it)
  • However, the effect of IL-35 and interaction between IL-35 and IL-17A on pro-inflammatory cytokine production in human periodontal resident cells are still unclear. (springer.com)
  • The antimicrobial peptide LL-37 is anti-inflammatory and proapoptotic in human periodontal ligament cells. (lu.se)
  • However, it is the dysregulated host immuno-inflammatory response that largely determines the extent and severity of periodontal disease [ 5 ]. (springer.com)
  • Host modulation therapy with anti-inflammatory agents has now been used as a promising adjunct to conventional periodontal management which mainly deals with the bacterial challenge [ 9 ]. (springer.com)
  • CONCLUSIONS: Within the limits of the study, the obtained results support the hypothesis of a modulatory role of VD on periodontal cells exposed to bacterial infection, reducing their inflammatory response and increasing the secretion of anti-inflammatory and modulatory cytokines. (minervamedica.it)
  • This basic-level course describes periodontal ligament injection techniques for administering local anesthetics to provide pulpal anesthesia when conventional infiltration and regional block methods are unsatisfactory or inadequate. (westernschools.com)
  • Periodontal diseases, caused by the bacterial biofilm, can affect up to 90% of adults worldwide [ 1 ]. (hindawi.com)
  • Provided are a composition for preventing or treating bone diseases and a composition for preventing or treating periodontal diseases, the compositions comprising the aforementioned peptide. (patents.com)
  • 12. A method for preventing or treating periodontal diseases, the method comprising administering a composition containing the peptide of any one of claims 1 to 6 as an active ingredient to a subject. (patents.com)
  • Periodontal Diseases and Rheumatoid Arthritis: A Coincident Model for Therapeutic Intervention? (eurekaselect.com)
  • Histological observation of the lingual cervical PDL (pressure zone) in nine 12- to 13-week-old rats demonstrated that the periodontal space had become narrow and the cellular elements appeared to be densely packed in the narrowed PDL 6 hours after orthodontic loading. (oup.com)
  • The results suggest that the periodontal reaction was initiated within 6 hours after orthodontic force loading, which was related to the structural changes of the PDL. (oup.com)
  • El ligamento periodontal es parte del periodonto de inserción, tiene fibroblastos. (wn.com)
  • Las fibras del ligamento periodontal tienen funciones tanto de inserción como de protección para el diente. (wn.com)
  • Clinical and histochemical alterations of the periodontal ligament in gerbils after malocclusion induced/Alteraciones clinicas e histoquimicas del ligamento periodontal en gerbiles despues de maloclusion inducida. (thefreelibrary.com)
  • RESUMEN: El objetivo de este articulo es mostrar las alteraciones clinicas e histoquimicas del primer ligamento periodontal del lado derecho, despues de la extraccion del molar superior izquierdo en gerbiles (Meriones unguiculatus). (thefreelibrary.com)
  • Recognize the advantages and disadvantages of periodontal ligament anesthesia. (westernschools.com)