Penile erection. Medical search

The state of the PENIS when the erectile tissue becomes filled or swollen (tumid) with BLOOD and causes the penis to become rigid and elevated. It is a complex process involving CENTRAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEMS; HORMONES; SMOOTH MUSCLES; and vascular functions.

The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.

A prolonged painful erection that may lasts hours and is not associated with sexual activity. It is seen in patients with SICKLE CELL ANEMIA, advanced malignancy, spinal trauma; and certain drug treatments.

The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.

Inability to achieve and maintain an erection (ERECTILE DYSFUNCTION) due to defects in the arterial blood flow to the PENIS, defect in venous occlusive function allowing blood drainage (leakage) from the erectile tissue (corpus cavernosum penis), or both.

An involuntary deep INHALATION with the MOUTH open, often accompanied by the act of stretching.

Compounds that specifically inhibit PHOSPHODIESTERASE 5.

A genus of the LAMIACEAE family. It is known for its mild calming effect and for the way cats are attracted to the aroma.

A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.

A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.

The emission of SEMEN to the exterior, resulting from the contraction of muscles surrounding the male internal urogenital ducts.

A potent vasodilator agent that increases peripheral blood flow.

An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.

A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in NERVE TISSUE.

Sexual union of a male and a female in non-human species.

A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.

A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

A condition characterized by hardening of the PENIS due to the formation of fibrous plaques on the dorsolateral aspect of the PENIS, usually involving the membrane (tunica albuginea) surrounding the erectile tissue (corpus cavernosum penis). This may eventually cause a painful deformity of the shaft or constriction of the urethra, or both.

Drugs that bind to and activate dopamine receptors.

The climax of sexual excitement in either humans or animals.

The psychic drive or energy associated with sexual instinct in the broad sense (pleasure and love-object seeking). It may also connote the psychic energy associated with instincts in general that motivate behavior.

Use of electric potential or currents to elicit biological responses.

An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic.

A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)

Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)

An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.

A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Nitric oxide release in penile corpora cavernosa in a rat model of erection. (1/478)

1. Nitric oxide (NO) levels were measured in the corpus cavernosum of urethane-anaesthetized rats by using differential normal pulse voltammetry with carbon fibre microelectrodes coated with a polymeric porphyrin and a cation exchanger (Nafion). A NO oxidation peak could be recorded at 650 mV vs. a Ag-AgCl reference electrode every 100 s. 2. This NO signal was greatly decreased by the NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME), given by local and systemic routes, and enhanced by the NO precursor L-arginine. Treatment with L-arginine reversed the effect of L-NAME on the NO peak. 3. Both the NO signal and the intracavernosal pressure (ICP) were increased by electrical stimulation of cavernosal nerves (ESCN). However, the rise in the NO levels long outlived the rapid return to baseline of the ICP values at the end of nerve stimulation. 4. The ICP and the NO responses to ESCN were suppressed by local and systemic injections of L-NAME. Subsequent treatment with L-arginine of L-NAME-treated animals restored the NO signal to basal levels and the NO response to ESCN. The ICP response to ESCN was restored only in part by L-arginine. 5. The observed temporal dissociation between the NO and ICP responses could be accounted for by several factors, including the buffering of NO by the blood filling the cavernosal spaces during erection. 6. These findings indicate that an increased production of NO in the corpora cavernosa is necessary but not sufficient for maintaining penile erection and suggest a complex modulation of the NO-cGMP-cavernosal smooth muscle relaxation cascade. (+info)

Nitric oxide and penile erection in streptozotocin-diabetic rats. (2/478)

The purpose of this investigation was to study the time course, response to insulin and characteristics of erectile dysfunction in streptozotocin (STZ)-diabetic Sprague-Dawley rats, and the function of the NO-generating system in these animals. Copulation-induced and reflex erection were quantified in conscious Sprague-Dawley rats at different times after injection of STZ. The corporal vasodilatation response to nerve stimulation was studied by measuring the rise in corporal pressure in pithed rats following electrical stimulation of sacral spinal nerve roots. The activity of NO synthase was determined in corporal tissue by measuring the generation of [3H]citrulline from [3H]arginine. Copulation-induced erection was inhibited at 1 and 2 months after STZ treatment, but this could be prevented by a short (2-week) pretreatment with insulin. Reflex erection was inhibited at 1, 4, 6 and 9 months after STZ; at 6 months, this inhibition was also reversible by insulin pretreatment. Following pithing, the basal corporal pressure was elevated in diabetic rats. At 4 months after STZ, this increase was normalized by a 2-week, but not by a 1-week, pretreatment with insulin; however, at 9 months after STZ, insulin pretreatment did not normalize corporal pressure. The increase in corporal pressure caused by stimulation of sacral nerve roots in pithed rats was enhanced in diabetic animals. This enhancement was also normalized at 4 months, but not at 9 months, by 2 weeks of insulin treatment. The inhibition of the stimulation-induced increase in corporal pressure by NG-nitro-L-arginine methyl ester (5 mg/kg) was less following 9 months of diabetes, although NO synthase activity was normal in cavernosal tissue following 6-8 months of diabetes. In conclusion, STZ-induced diabetes caused changes in the erectile system that were initially reversible by a short insulin treatment, but which with time (more than 6 months) became irreversible. NO synthase activity in cavernosal tissue was normal, but the response to NG-nitro-L-arginine methyl ester was inhibited in long-term diabetes (9 months). (+info)

Cardiac autonomic function during sleep in psychogenic and organic erectile dysfunction. (3/478)

The present study investigated the sympathetic/parasympathetic balance during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep in patients with psychogenic and organic erectile dysfunction. The cardiac autonomic balance was assessed from the power of the low frequency (LF) and high frequency (HF) spectral components of heart-rate variability in 11 patients with psychogenic erectile dysfunction and 11 patients with organic erectile dysfunction as determined by monitoring sleep-related erections. Spectral analysis of heart-rate variability was calculated for at least four successive 4-min epochs of electrocardiogram recordings during NREM sleep and for all available 4-min epochs during REM sleep. Statistical analysis revealed that organic patients had a significantly higher LF/HF ratio (P < 0.01) during both stages of sleep, which resulted from a significantly lower power in the HF component (P < 0.004) and higher power in the LF component (P < 0.01) in these patients, in both REM and NREM sleep stages. These results demonstrate that patients complaining of daytime sexual dysfunction and found by sleep-related erection monitoring to suffer from organic erectile dysfunction, have altered cardiac autonomic balance during both stages of sleep. (+info)

Selective nitrergic neurodegeneration in diabetes mellitus - a nitric oxide-dependent phenomenon. (4/478)

1. In vitro and in vivo studies have demonstrated a dysfunctional nitrergic system in diabetes mellitus, thus explaining the origin of diabetic impotence. However, the mechanism of this nitrergic defect is not understood. 2. In the penises of streptozotocin (STZ)-induced diabetic rats, here, we show by immunohistochemistry that nitrergic nerves undergo selective degeneration since the noradrenergic nerves which have an anti-erectile function in the penis remained intact. 3. Nitrergic relaxation responses in vitro and erectile responses to cavernous nerve stimulation in vivo were attenuated in these animals, whereas noradrenergic responses were enhanced. 4. Activity and protein amount of neuronal nitric oxide synthase (nNOS) were also reduced in the penile tissue of diabetic rats. 5. We, thus, hypothesized that NO in the nitrergic nerves may be involved in the nitrergic nerve damage, since only the nerves which contain neuronal NO synthase underwent degeneration. 6. We administered an inhibitor of NO synthase, N(G)-nitro-L-arginine methyl ester (L-NAME), in the drinking water of rats for up to 12 weeks following the establishment of diabetes with STZ. 7. Here we demonstrate that this compound protected the nitrergic nerves from morphological and functional impairment. Our results show that selective nitrergic degeneration in diabetes is NO-dependent and suggest that inhibition of NO synthase is neuroprotective in this condition. (+info)

Effects of sildenafil (Viagra) administration on seminal parameters and post-ejaculatory refractory time in normal males. (5/478)

Sildenafil is a specific inhibitor of phosphodiesterase (PDE) type 5 and represents a powerful therapy for male erectile dysfunction (ED) of different aetiology. Recently, sildenafil has been shown to restore erections in temporary ED related to the need of semen collection for assisted reproductive techniques. In this study, we investigated whether sildenafil administration modifies seminal parameters and/or erectile function in normal healthy volunteers. In a double-blind, randomized, placebo-controlled, cross-over two period investigation we enrolled 20 healthy male volunteers (mean +/- SE age 32 +/- 0.5 years). Subjects were not using any medication for the 3 month period prior to the study and were engaged in a stable relationship with proven fertility. The effects of sildenafil (100 mg) on seminal parameters and erectile function after audiovisual sexual stimulation were evaluated by semen analysis and by colour-Duplex ultrasound (the Resistive Index) respectively. In all subjects, sildenafil caused no changes in seminal and erection parameters when compared to placebo. Interestingly, sildenafil administration led to a marked reduction of the post-ejaculatory refractory time (10.8 +/- 0.9 min versus 2.6 +/- 0.7 min for placebo and sildenafil respectively; P < 0.0001). These results indicate that in normal subjects acute sildenafil treatment does not modify semen characteristics and has a positive influence over the resumption of erections following ejaculation in the presence of a continuous erotic stimulus. (+info)

Diagnostic evaluation of erectile dysfunction. (6/478)

Erectile dysfunction, the persistent inability to attain or maintain penile erection sufficient for sexual intercourse, affects millions of men to various degrees. The majority of cases have an organic etiology, most commonly vascular disease that decreases blood flow into the penis. Regardless of the primary cause, erectile dysfunction can have a negative impact on self-esteem, quality of life and interpersonal relationships. The initial step in evaluation is a detailed medical and social history, including a review of medication use. Discussion with the patient's sexual partner may clarify exacerbating issues. The physical examination focuses on the cardiovascular, neurologic and urogenital systems. Laboratory tests are useful to screen for common etiologic factors and, when indicated, to identify hypogonadal syndromes. Appropriate evaluation of erectile dysfunction leads to accurate advice, management and referral of patients with erectile dysfunction. (+info)

Effects of intracavernous administration of selective antagonists of alpha(1)-adrenoceptor subtypes on erection in anesthetized rats and dogs. (7/478)

The proerectile properties of three novel alpha(1)-adrenoceptor (alpha(1)-ADR) antagonists with different profiles of selectivity for the alpha(1)-ADR subtypes have been evaluated in anesthetized rats and dogs on intracavernous (IC) injection, in comparison with prazosin and phentolamine. In rats, the tested compounds decreased blood pressure (BP) and increased IC pressure (ICP), as well as the ratio ICP/BP. Rec 15/2841 (alpha(1a)- plus alpha(1L)-ADR-selective antagonist) and Rec 15/2615 (alpha(1b)-ADR selective) were the most potent compounds. The ICP/BP ratios calculated after injection of Rec 15/3039 (alpha(1d)-ADR selective) were not markedly different from those observed after vehicle injection. Prazosin and phentolamine proved poorly active, their main effect being hypotension. Approximate ED(25) values (dose of compound in micrograms inducing 25% increase of ICP/BP ratio) were Rec 15/2615 (22 microgram/kg)>= Rec 15/2841 (29 microgram/kg) > prazosin (136 microgram/kg) > phentolamine (1298 microgram/kg) > Rec 15/3039 (9600 microgram/kg). Submaximal stimulation of the cavernous nerve elicited an ICP rise whose amplitude was not altered by Rec compounds. In contrast, prazosin and phentolamine decreased this ICP rise. All compounds but 15/3039 induced significant increase of the ICP/BP ratio in dogs. Rec 15/2615 proved to be the most interesting compound, inducing significant increases of ICP/BP at doses practically devoid of effects on BP. The rank order of potency in dog in increasing the ICP/BP ratio was similar to that observed in rats. Only at the highest doses tested, all compounds, except Rec 15/3039, decreased the ICP rise elicited by submaximal stimulation of the cavernous nerve. Our data demonstrate that the alpha(1b)- and alpha(1L)-ADR subtypes are functionally relevant for the erectile function in these models, and that alpha(1b)- and/or alpha(1L)-ADR subtypes selective antagonists could represent a real advantage in erectile dysfunction therapy. (+info)

Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. (8/478)

The generation of nitric oxide (NO) in penile erectile tissue and the subsequent elevation of cyclic GMP (cGMP) levels are important for normal penile erection. Current treatments of erectile dysfunction elevate either cGMP levels by blocking cGMP degrading phosphodiesterase 5 or cyclic AMP (cAMP) levels by intrapenile injection of prostaglandin E1. The molecular target or targets of cGMP in erectile tissue and the role of cAMP for normal penile erection are not known. Herein, we report that mice lacking cGMP-dependent kinase I (cGKI) have a very low ability to reproduce and that their corpora cavernosa fail to relax on activation of the NO/cGMP signaling cascade. Elevation of cAMP by forskolin, however, induces similar relaxation in normal and cGKI-null corpus cavernosum. In addition, sperm derived from cGKI-null mice is normal, can undergo acrosomal reactions, and can efficiently fertilize eggs. Altogether, these data identify cGKI as the downstream target of cGMP in erectile tissue and provide evidence that cAMP signaling cannot compensate for the absence of the cGMP/cGKI signaling cascade in vivo. (+info)

Penile erection; 3b. Vaginal lubrication, 4. Ability to reach orgasm, 5. Satisfaction from orgasm. Only one item of the scale ... Clitoral photoplethysmograph Labial thermistor clip Penile plethysmograph Vaginal photoplethysmograph Del Re G., Bazzo G., ...

https://en.wikipedia.org/wiki/Sexological_testing

Ce2 kei4 (扯旗) - Literally to raise a flag; Penile erection. 26 Tau1 sik6 (偷食) - Literally to sneak food; Adultery, Infidelity ...

https://en.wikipedia.org/wiki/Hong_Kong_slang

Blockage of these brain adrenoreceptors appears to reverse a central negative feedback mechanism that regulates penile erection ... Andersson KE (December 2011). "Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction". ... Andersson KE (September 2001). "Pharmacology of penile erection". Review. Pharmacological Reviews. 53 (3): 417-50. PMID ...

https://en.wikipedia.org/wiki/Yohimbine

Penile erection is a hemodynamic event in the smooth muscle of corpus cavernous. PDE5 is the main cGMP hydrolysing enzyme found ... As demonstrated in figure 1, inhibition of PDE5 reduces degradation of cGMP and leads to penile erection. Because of this ... Sildenafil did not prove effective for coronary heart disease but an interesting side effect was discovered, a penile erection ... Lower intracellular calcium leads to smooth muscle relaxation and ultimately penile erection. This pathway is demonstrated in ...

https://en.wikipedia.org/wiki/Discovery_and_development_of_phosphodiesterase_5_inhibitors

Chen, J.; Gefen, A.; Greenstein, A.; Matzkin, H.; Elad, D. (2000). "Predicting penile size during erection". International ... Wessells, H.; Lue, T. F.; McAninch, J. W. (1996). "Penile length in the flaccid and erect states: Guidelines for penile ...

https://en.wikipedia.org/wiki/Anthropometry

Clinically, erection is often known as "penile erection", and the state of being erect, and process of erection, are described ... An erection (clinically: penile erection or penile tumescence) is a physiological phenomenon in which the penis becomes firm, ... Erections during sleep or upon waking up are known as nocturnal penile tumescence (NPT), also known as "morning wood". Absence ... Penile erection is the result of a complex interaction of psychological, neural, vascular, and endocrine factors, and is often ...

https://en.wikipedia.org/wiki/Erection

... melanotropic peptides and penile erection". Curr Top Med Chem. 7 (11): 1098-1106. doi:10.2174/1568026610707011111. PMC 2694735 ... An additional analogue called melanotan II causes enhanced libido and erections in most male test subjects and arousal with ...

https://en.wikipedia.org/wiki/Melanocyte-stimulating_hormone

... melanotropic peptides and penile erection". Current Topics in Medicinal Chemistry. 7 (11): 1098-1106. doi:10.2174/ ...

https://en.wikipedia.org/wiki/THIQ

Ongoing penile erections for more than 6 hours can be classified as priapism." Priapism in females (continued, painful erection ... Newman Herbert F., Northup Jane D. (1981). "Mechanism of human penile erection: an overview". Urology. 17 (5): 399-408. doi: ... Pain can often be reduced with a dorsal penile nerve block or penile ring block. For those with nonischemic priapism, cold ... Persistent semi-erections and intermittent states of prolonged erections have historically been sometimes called semi-priapism ...

https://en.wikipedia.org/wiki/Priapism

... melanotropic peptides and penile erection". Current Topics in Medicinal Chemistry. 7 (11): 1098-1106. doi:10.2174/ ...

https://en.wikipedia.org/wiki/Melanocortin_receptor

... melanotropic peptides and penile erection". Current Topics in Medicinal Chemistry. 7 (11): 1098-1106. doi:10.2174/ ... injected himself with twice the dose he intended and experienced an eight-hour erection, along with nausea and vomiting. To ...

https://en.wikipedia.org/wiki/Bremelanotide

... melanotropic peptides and penile erection". Curr Top Med Chem. 7 (11): 1098-1106. doi:10.2174/1568026610707011111. PMC 2694735 ... injected himself with twice the dose he intended to and got an eight-hour erection, along with nausea and vomiting. As a ...

https://en.wikipedia.org/wiki/Melanotan_II

Penile erection tissue by release of nitric oxide. Reactive hyperaemia, a sub-category of arterial hyperaemia, is the transient ...

https://en.wikipedia.org/wiki/Hyperaemia

Cará AM, Lopes-Martins RA, Antunes E, Nahoum CR, De Nucci G (February 1995). "The role of histamine in human penile erection". ... The injection of histamine into the corpus cavernosum in men with psychogenic impotence produces full or partial erections in ...

https://en.wikipedia.org/wiki/Histamine

Penile implants may be employed to treat erectile dysfunction or urinary troubles after a spinal cord injury. Penile erection ... Soft penile implants seem to carry less risk of penile perforation in patients with SCI. The inflatable penile implant is ... Penile implants are used in treating erectile dysfunction in men who fail medical therapy. Several types of penile implant ... Soft penile implants might be more suitable for use in men with SCI and, in addition, they seem to carry less risk of ...

https://en.wikipedia.org/wiki/Penile_implants_in_spinal_cord_injury

Dean, Robert C.; Lue, Tom F. (2005-2011). "Physiology of Penile Erection and Pathophysiology of Erectile Dysfunction". The ... Penile spines also occur on the glans of male and female spotted hyenas. In male dogs, the glans penis consists of two parts ... The frenulum is supple enough to allow the retraction of the foreskin over the glans and pull it back when the erection is gone ... Yang, C. C.; W.E. Bradley (July 1998). "Neuroanatomy of the penile portion of the human dorsal nerve of the penis". British ...

https://en.wikipedia.org/wiki/Glans_penis

Brioni, Jorge D.; Moreland, Robert B. (2006). "Dopamine D4 receptors and the regulation of penile erection". Drug Discovery ...

https://en.wikipedia.org/wiki/PF-219,061

"Alternatively spliced neuronal nitric oxide synthase mediates penile erection". Proc Natl Acad Sci U S A. 103 (9): 3440-3. ... "Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection". Proc Natl Acad Sci USA. 99 (6): ... "Phosphorylated endothelial nitric oxide synthase mediates vascular endothelial growth factor-induced penile erection". Biol ... Palese, MA; Burnett, AL (December 2001). "Corporoplasty using pericardium allograft (tutoplast) with complex penile prosthesis ...

https://en.wikipedia.org/wiki/Michael_Palese

Act in the corpus cavernosum to maintain penile erection. Specific epoxidation of EET sites produces endogenous PPARα agonists ... "Cytochrome P450 epoxygenases provide a novel mechanism for penile erection". FASEB Journal. 20 (3): 539-41. doi:10.1096/fj.05- ...

https://en.wikipedia.org/wiki/Epoxyeicosatrienoic_acid

See nocturnal penile tumescence.) The primary physiological mechanism that brings about erection is the autonomic dilation of ... Sparling J (1997). "Penile erections: shape, angle, and length". Journal of Sex & Marital Therapy. 23 (3): 195-207. doi:10.1080 ... It is thought that the relatively quick loss of erection after ejaculation, penile hypersensitivity following ejaculation, and ... Erections can occur in non-sexual situations; spontaneous non-sexual erections frequently occur during adolescence and sleep. ...

https://en.wikipedia.org/wiki/Human_penis

... requires an implanted penile prosthesis to achieve an erection. Penile prostheses are implanted devices intended ... "Shortened penis post penile prosthesis implantation treated with subcutaneous soft silicone penile implant: case report". ... Penile implants have been used in phalloplasty surgeries both in cisgender and transgender patients since 1970s. There are two ... Initially, standard penile implants were used in phalloplasty procedures. However, since there is no corpus cavernosum in the ...

https://en.wikipedia.org/wiki/Phalloplasty

Phatarpekar PV, Wen J, Xia Y (November 2010). "Role of adenosine signaling in penile erection and erectile disorders". The ... On the other hand, excess adenosine in penile tissue contributes to priapism. The bronchoalveolar lavage (BAL) fluid of ...

https://en.wikipedia.org/wiki/Purinergic_signalling

"Absence of penile erections during paradoxical sleep. Peculiar penile events during wakefulness and slow wave sleep in the ... During paradoxical sleep, no erections occur, and the penile muscles share the characteristics of the rest of the body. ... During its slow wave sleep phase, penile protrusion makes some very complex movements. The penis during this phase is not erect ...

https://en.wikipedia.org/wiki/Big_hairy_armadillo

Periodic spontaneous erection and penile movements known as masturbation (SEAM) occur normally at approximately 90 min ... The varieties of mounting include mounting without erections, mounting with erection but no insertion, and mounting from the ... involves normal periodic erections and penile movements. This behavior, both from the descriptive field studies cited above and ... McDonnell, S.M.; Henry, M.; Bristol, F. (1991). "Spontaneous erection and masturbation in equids" (PDF). J Reprod Fertil Suppl ...

https://en.wikipedia.org/wiki/Non-reproductive_sexual_behavior_in_animals

Affanni, J. M.; Cervino, C. O.; Marcos, H. J. A. (2001). "Absence of penile erections during paradoxical sleep. Peculiar penile ... An erection is the stiffening and rising of the penis, which occurs during sexual arousal, though it can also happen in non- ... The male echidna's penis is 7 cm (3 in) long when erect, and its shaft is covered with penile spines. The penis is nearly a ... The penis of a dromedary camel is covered by a triangular penile sheath opening backwards, and is about 60 cm (24 in) long. The ...

https://en.wikipedia.org/wiki/Penis

Spasms of the internal urethral sphincter are associated with penile erection. Because the internal urethral sphincter is under ...

https://en.wikipedia.org/wiki/Internal_urethral_sphincter

US patent 4585005, Tom P. Lue, Emil A. Tanagho, and Richard A. Schmidt, "Method and pacemaker for stimulating penile erection ... "Method and pacemaker for stimulating penile erection". Other kinds of apparatus use interferential currents with four surface ... and other items for penile application. The pads used with TENS units are also used in the sexual application of ...

https://en.wikipedia.org/wiki/Erotic_electrostimulation

It is also observed that penile erection may occur after being stung. The pain of a sting from the Arizona Bark Scorpion has ... VIP is the strongest relaxant of penile smooth muscle structure, resulting in an erection upon envenomation. This is the ... This prolonged activity of sodium channels results in an erection. There may be nerve damage due to the stabilization of ...

https://en.wikipedia.org/wiki/Scorpionism_in_Central_America

https://en.wikipedia.org/wiki/Scorpion_sting

Benassi-Benelli A, Ferrari F, Quarantotti BP (December 1979). "Penile erection induced by apomorphine and N-n-propyl- ... In rodents it has been shown to produce hyperactivity, stereotypy, hypothermia, antinociception, and penile erection, among ...

https://en.wikipedia.org/wiki/Propylnorapomorphine

This surgical approach allowed for removal of the prostate and lymph nodes with maintenance of penile function. In 1941, ... such as difficulty achieving erection or painful ejaculation. Metastatic prostate cancer can cause additional symptoms. The ... Other nonpharmacological therapy includes vacuum constriction devices and penile implants. Psychological interventions such as ... prostatectomy for symptomatic relief of obstruction in the middle of the 20th century because it could better preserve penile ...

https://en.wikipedia.org/wiki/Prostate_cancer

April 2004). "Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats". Proceedings of the National ...

https://en.wikipedia.org/wiki/ABT-724

Lehrfeld T, Lee DI (2009). "The role of vacuum erection devices in penile rehabilitation after radical prostatectomy". ... Min KS (2016). "Chapter 20: Penile traction therapy (penile lengthening device". In Park NC, Kim SW, Moon DG (eds.). Penile ... Surgical penis enlargement methods include penile augmentation and suspensory ligament release. Penile augmentation involves ... extending the duration of erections, or enhancing sexual climax. Commonly called a "penis pump", a vacuum erection device, or ...

https://en.wikipedia.org/wiki/Penis_enlargement

Nocturnal penile tumescence Swelling (medical) Nocturnal clitoral tumescence Erection Priapism Nocturnal emission Sleep sex ... Something that causes an erection is sometimes referred to as a tumefier (tumefyer) or tumescer. ...

https://en.wikipedia.org/wiki/Tumescence

... for a hemodynamic confirmation of the penile veins as a significant contributor for penile erection. Hsu is featured in several ... Hsu documents and shares his clinical experience on penile reconstruction, particularly of penile venous stripping, penile ... He is also author of "A Laboratory for Potency Microsurgery." He has patented a penile venous stripping procedure under the U.S ... curvature correction, and penile enhancement via various academic channels.[citation needed] That includes his contributions to ...

https://en.wikipedia.org/wiki/Geng_Long_Hsu

In teenagers and adults, it may result in pain during an erection, but is otherwise not painful. Those affected are at greater ... September 2005). "Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease ...

https://en.wikipedia.org/wiki/Phimosis

... a plant pathogenic virus Phantom vibration syndrome Penile vibratory stimulation, a means of inducing erection and ejaculation ...

https://en.wikipedia.org/wiki/PVS

"Penile erection induced in vivo by a purified toxin from the Brazilian spider Phoneutria nigriventer". British Journal of ...

https://en.wikipedia.org/wiki/Arthropods_in_culture

When not in use, its soft penile tissue is usually flaccid, and depending on the species, may be retracted into the body. The ... Brennan, P.L.R.; Prum, R.O.; Hayssen, Virginia (February 2012). "The erection mechanism of the ratite penis" (PDF). Journal of ... During copulation, blood engorges the already-stiff penis resulting in a full erection. Monotreme penes are variously unusual; ... ISBN 978-0-8018-4780-6. "Baculum (penile bone) in mammals". Map of Life. Retrieved 23 August 2015. Grant, Tom (1995). The ...

https://en.wikipedia.org/wiki/Intromittent_organ

... and penile erection. NO is also responsible for endothelium-derived relaxing factor activity regulating blood pressure as ...

https://en.wikipedia.org/wiki/NOS1

Angulo JC, García-Díez M (2009). "Male Genital Representation in Paleolithic Art: Erection and Circumcision Before History". ... consider the penile subincision performed by some Indigenous Australians), and practicing them marked people as members of a ...

https://en.wikipedia.org/wiki/Prehistoric_religion

Erection and protrusion take place gradually, by the increasing tumescence of the erectile vascular tissue in the corpus ... "penile sheath". Stallions have a vascular penis. When non-erect, it is quite flaccid and contained within the sheath. The ...

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"Pharmacological methods of enhancing penile erection for ex-copula semen collection in standing white rhinoceros (Ceratotherium ... The penile vibratory stimulator is a plier-like device that is placed around the glans penis to stimulate it by vibration, and ... Penile vibratory stimulation (PVS) and electroejaculation are two other alternatives for men with anejaculation due to spinal ... penile vibratory stimulation (vibroejaculation) and electroejaculation. Semen can be collected from endangered species for ...

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... slang for a penile erection Chubby, slang for a spliff Chub (disambiguation) Chub (gay culture), also called "chubby culture" ...

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In this study, men reported no improvements in maintaining erections or an increase of penile firmness. Women reported no ...

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"5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists". ...

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... or penile implants. In a 2006 study looking at patients' quality of life, LDR brachytherapy compared favourably with other ... difficulty getting and/or keeping an erection; impotence) is another side-effect associated with some surgical and non surgical ...

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Self-reported symptoms of post-finasteride syndrome include penile atrophy and tissue changes, decreased ejaculate volume and ... trouble getting or keeping an erection, decrease in sex drive, decreased volume of ejaculate and ejaculation disorders.: 16 A ... problems with ejaculation and difficulty achieving an erection which continued after stopping the medication. The update also ... quality, libido loss, erectile dysfunction, loss of penile sensitivity, decreased orgasm sensation, dry skin, metabolic changes ...

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... creating penile rigidity --a true erection. The lack of this plexus in the clitoris indicates that while the organ can become ... Erections should eventually subside, and the prolonged state of clitoral erection even while not aroused is a condition that ... Clitoral erection is a physiological phenomenon where the clitoris becomes enlarged and firm. Clitoral erection is the result ... similar to its role in penile erection. The clitoris is the homologue of the penis in the female. Similarly, the clitoris and ...

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... but it could induce marked penile erections. Pfizer therefore decided to market it for erectile dysfunction, rather than for ... Rare but serious side effects include a prolonged erection (priapism) that can lead to damage to the penis, vision problems, ... When taken by mouth sildenafil for erectile dysfunction results in an average time to onset of erections of 27 minutes (ranging ... Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. ...

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... penile erection (priapism) that lasts for several hours, and in several documented cases, death. Phoneutria nigriventer is a ... Erections resulting from the bite are uncomfortable, can last for many hours and can lead to impotence. A component of the ... Natural Viagra: Spider bite causes prolonged erection. Live Science, April 30, 2007. Accessed July 9, 2019. Szalay, Jessie. " ... and an immediate erection. He was treated with anesthetics, tetanus prophylaxis and antivenom, recovering 36 hours after the ...

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Equally, a male erection can occur during sleep (nocturnal penile tumescence) without conscious sexual arousal or due to ... Arousal non-concordance is when there is no link, for example in morning erection which happens both with men (Nocturnal penile ... The most obvious response involved with sexual behaviour in males is penile erection. The use of the volume (or circumference) ... change during penile erection as a convenient measure of sexual arousal was first developed by Kurt Freund. This measurement of ...

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... such a diagnosis if a man has relatively frequent nocturnal penile tumescence since he will probably not notice his erections ... Medomalacuphobia, the fear of losing an erection or acquiring erectile dysfunction, is its antonym. At its most extreme, ... Although usually referring to ordinary erections, the term has also been used in toxicological and therapeutic contexts. ... hearing the word penis or thinking about an erection. The phobia may have developed from a condition such as dyspareunia, a ...

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Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening ...

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Hello I started masturbating when I was 13 years... I use to get strong erection but now my penis cant get hard erection, is ... My penis just not responding i masturbated but next morning its just not working i get erections but not random like usual?. ... Hi i masturbate a lot than usual before two days ago and now i cant feel my penis anymore still cant get an erection or ... now my penis gets veiny after masturbation and its taking longer to get an erection. please help.. 1 doctor answer • 1 doctor ...

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Dive into the research topics of RhoA/Rho-kinase: A novel player in the regulation of penile erection. Together they form a ... RhoA/Rho-kinase: A novel player in the regulation of penile erection. ...

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Testosterone boosters, glutamine takes several weeks to take and duration of penile erections. Food and supplements because of ...

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Melman A, Henry D. The possible role of the catecholamines of the corpora in penile erection. Journal of Urology. 1979;121(4): ... Melman, A., & Henry, D. (1979). The possible role of the catecholamines of the corpora in penile erection. Journal of Urology, ... Melman, A & Henry, D 1979, The possible role of the catecholamines of the corpora in penile erection, Journal of Urology, vol ... Melman, A. ; Henry, D. / The possible role of the catecholamines of the corpora in penile erection. In: Journal of Urology. ...

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After 2 days i try to get an erection and it was realy hard a... ... Painful nocturnal erections, AV fistula left penile artery, ... After 2 days i try to get an erection and it was realy hard and needed constant stimulation and i notice that head of my penis ... Hi everyone, I am 27 years old and for the last 2 years I have been suffering from painful nocturnal erections. Basically, I go ... Hi everyone, I am 27 years old and for the last 2 years I have been suffering from painful nocturnal erections. Basically, I go ...

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Phosphodiesterase-5 Inhibitors and Vacuum Erection Device for Penile Rehabilitation after Laparoscop. ... PHOSPHODIESTERASE-5 INHIBITORS AND VACUUM ERECTION DEVICE FOR PENILE REHABILITATION AFTER LAPAROSCOPIC NERVE-PRESERVING RADICAL ...

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François Gigot de Peyronie is widely credited for first describing penile curvature, now known as Peyronie disease (PD), in ... Penile angulation, which may be apparent only with an erection or may be noted in a flaccid penis ... 1] PD is characterized by curvature in the penile shaft (see the image below) that is often preceded by painful erections and ... The penile curvature is often preceded by painful erections and may be associated with ED. ...

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2 Andersson K . et al . Physiology of penile erection. Physiol Rev. 1995; 75 191-236 ... old rat penile tissues is associated with erectile dysfunction. Int J Impot Res. 1999; 11 201-206 ...

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Thalamus and penile erection. Temel Y, Visser-Vandewalle V, Ackermans L, Beuls EA. Temel Y, et al. Among authors: visser ...

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RhoA/Rho-kinase: a novel player in the regulation of penile erection. Int J Impot Res. 2001 Apr. 13(2):67-72. [QxMD MEDLINE ... The nocturnal penile tumescence test is conducted on several nights to obtain an accurate indication of erections that normally ... Androgens and penile erection: evidence for a direct relationship between free testosterone and cavernous vasodilation in men ... These agents do not directly cause penile erections but affect instead the response to sexual stimulation. Sildenafil was the ...

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Erection, Penile; Sleep-Related. *Erlanger, Joseph. *Essential Tremor. *Ethanol. *Ethical Issues. *Euler, Ulf von ...

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... resulting in relaxation of penile smooth muscle, inward blood flow, and penile erection.[27] In the cAMP signaling pathway, ... Erectile dysfunction (ED) refers to the inability of men to meet their normal sexual life because of penile erection.[1] ... 30]. Xu CX, Jiang R. [Raf/MEK/ERK1/2 signaling pathway and penile erection]. Zhonghua Nan Ke Xue. 2010;16:354-8.. * Cited Here ... Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction. Pharmacol Rev. 2011;63:811-59.. ...

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The nocturnal penile tumescence test is conducted on several nights to obtain an accurate indication of erections that normally ... RhoA/Rho-kinase: a novel player in the regulation of penile erection. Int J Impot Res. 2001 Apr. 13(2):67-72. [QxMD MEDLINE ... The nocturnal penile tumescence test is conducted on several nights to obtain an accurate indication of erections that normally ... Androgens and penile erection: evidence for a direct relationship between free testosterone and cavernous vasodilation in men ...

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Infant boys also normally experience frequent penile erections, often just before they urinate. ...

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Immediate medical attention should be sought if signs or symptoms of prolonged penile erections or priapism are observed (5.5). ... Advise patients of the possibility of painful or prolonged penile erections (priapism). Instruct them to seek immediate medical ... Priapism: Cases of painful and prolonged penile erections and priapism have been reported with methylphenidate products. ... painful and prolonged erections (priapism) have occurred with methylphenidate. If you or your child develops priapism, seek ...

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On the basis of these study results, the physician should be able to determine the medical status of the patient, to identify and characterize the type of dysfunction, and to determine the need for additional testing (eg, penile or pelvic blood flow studies, nocturnal penile tumescence testing, or other blood tests). (medscape.com)
Erections during sleep, called Nocturnal Penile Tumescence (NPT), are a natural part of men's health. (rexmd.com)

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Objectives: To evaluate the expression of nitric oxide synthase (NOS)-containing nerve fibers in penile tissue in different age groups in the rat and to measure serum testosterone levels during this developmental process. (ajol.info)
Tion and epidemiology of ed may be made available some of you after the sexually a loss of endothelial nitric-oxide synthase mediates penile erection. (psm.edu)
In the hemodynamic process of penile erection, nitric oxide (NO) is produced and released in the corpus cavernosum of the penis from nerve endings and endothelial cells during sexual stimulation. (prescriptionpoint.com)
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PDE5 enzymes negate the synthesis of nitric oxide which ensures proper erection function. (heroes.app)
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[ 1 ] PD is characterized by curvature in the penile shaft (see the image below) that is often preceded by painful erections and accompanied by an area of fibrosis. (medscape.com)
The penile curvature is often preceded by painful erections and may be associated with ED. (medscape.com)
Usta et al found that the presence of diabetes, hyperlipidemia, hypercholesteremia, or hypertension was not statistically related to the severity of penile curvature in men with PD. (medscape.com)
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As the position of the external meatus becomes more proximal, ventral shortening and curvature during erection are more likely [4]. (who.int)

If successful, this test also establishes penile injections as a possible therapy. (medscape.com)
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Botox injections will block the release of this hormone and increase the blood flow to the spongy and cavernous bodies providing an excellent erection. (barefootsworld.net)
For this pilot study, patients enrolled had severe erectile dysfunction considered to be irreversible following radical prostatectomy, i.e. the maximum medical treatment (prostaglandin injections into the penis + maximum doses of Viagra ® and the use of a vacuum (erection pump [1] )) remained ineffective after an average period of two years. (inserm.fr)
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The secondary objectives of the study were to evaluate the effects of the cell transplant on the quality of erections, sexual intercourse and the penile vessels. (inserm.fr)
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Melman, A & Henry, D 1979, ' The possible role of the catecholamines of the corpora in penile erection ', Journal of Urology , vol. 121, no. 4, pp. 419-421. (elsevier.com)
The tunica albuginea helps to trap the blood in the corpora cavernosa, thereby sustaining erection. (news24.com)
Consequently, additional blood rushes to your penile cells or corpora cavernosa, resulting in a strong erection and also longer size. (rapportjapan.info)

Cases of painful and prolonged penile erections and priapism have been reported with methylphenidate products. (nih.gov)
Immediate medical attention should be sought if signs or symptoms of prolonged penile erections or priapism are observed (5.5). (nih.gov)
Priapism is a condition resulting in a prolonged and uncontrolled erection. (auanet.org)
Priapism is a persistent penile erection that continues hours beyond, or is unrelated to, sexual stimulation. (auanet.org)
Acute ischemic (venoocclusive, low flow) priapism is a nonsexual, persistent erection characterized by little or no cavernous blood flow and abnormal cavernous blood gases (ie hypoxic, hypercarbic, acidotic). (auanet.org)
As the natural history of untreated acute ischemic priapism includes days to weeks of painful erections followed by permanent loss of erectile function, the condition requires prompt evaluation and may require emergency management. (auanet.org)
Resolution of acute ischemic priapism is characterized by the penis returning to a flaccid, nonpainful state, with restoration of penile blood flow. (auanet.org)
However, oftentimes persistent penile edema, ecchymosis and partial erections occur and mimic unresolved priapism. (auanet.org)
The term recurrent ischemic priapism, commonly known as "stuttering" priapism," signifies an intermittent, recurrent subtype of ischemic priapism, in which unwanted painful erections occur repeatedly with intervening periods of detumescence. (auanet.org)

This lack of rigidity seems to be the result of compromise to the distal penile blood supply. (medscape.com)
Hypospadias is a congenital defect of the penis resulting in incomplete development of the penile urethra, the external urethral meatus may be anywhere along the ventral surface of the penis, ventral surface of the glans (glanular hypospadias), in the penis shaft distally (distal penile hypospadias) or proximally (proximal penile hypospadias), down to the scrotum (scrotal hypospadias) or even in the perineum (perineal). (who.int)

Penile erection was evaluated using cavernous nerve electrostimulation. (ajol.info)
The onset of tadalafil citrate action, and with the right application and observance of life and erection, which controls the dilation and contraction of the cavernous bodies. (bitcoinenespanol.net)

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The effects of cell transplantation were assessed by specific self-administered questionnaires that scored the main aspects of sex life, namely satisfaction with intercourse, erectile and orgasm functions, libido, and penile rigidity during intercourse. (inserm.fr)
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A single intraurethral agent, PGE1, which has been formulated into a small suppository, is commercially available as a component of the Medicated Urethral System for Erections (MUSE). (medscape.com)
a total of 21 circumcised patients with a mean age of 39 (range 11 - 79) years underwent penile circular fasciocutaneous flap urethroplasty for urethral strictures involving the penile and bulbar tracts. (bvsalud.org)

Men who have trouble having erections should talk to their health care providers. (medscape.com)

Symptoms that aid in the diagnosis of psychogenic ED include abrupt onset, intermittent character, loss of erection maintenance, quality nocturnal erection, and excellent response to phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil, vardenafil). (bvsalud.org)

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It can manifest as an inability to maintain an erection or difficulty achieving orgasm, or can involve an inability to be present in the moment. (thirdage.com)
A simple recounting of sexual activity might distinguish between problems with erection, ejaculation, orgasm, or sexual desire. (news24.com)
After six months, significant improvements in the quality of sexual intercourse, erection, penile rigidity and quality of orgasm were reported by the patients, according to a study by Inserm. (inserm.fr)

Erectile dysfunction (when the man is not able to get the penis up or the erection lasts too short) happens due to the release of the neurotransmitter norepinephrine, which prevents blood flow. (barefootsworld.net)
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This leads to the activation of the enzyme guanylate cyclase to convert guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP), which is mainly responsible for relaxing the smooth muscle cells in the corpus cavernosum that allows increased blood flow into the penis, resulting in an erection. (prescriptionpoint.com)
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Anatomy2

Organisms2

Diseases4

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Psychiatry and Psychology3

Phenomena and Processes5

Nitric oxide release in penile corpora cavernosa in a rat model of erection. (1/478)

Nitric oxide and penile erection in streptozotocin-diabetic rats. (2/478)

Cardiac autonomic function during sleep in psychogenic and organic erectile dysfunction. (3/478)

Selective nitrergic neurodegeneration in diabetes mellitus - a nitric oxide-dependent phenomenon. (4/478)

Effects of sildenafil (Viagra) administration on seminal parameters and post-ejaculatory refractory time in normal males. (5/478)

Diagnostic evaluation of erectile dysfunction. (6/478)

Effects of intracavernous administration of selective antagonists of alpha(1)-adrenoceptor subtypes on erection in anesthetized rats and dogs. (7/478)

Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. (8/478)

Penile Erection

Penis

Priapism

Erectile Dysfunction

Impotence, Vasculogenic

Yawning

Phosphodiesterase 5 Inhibitors

Nepeta

Sulfones

Apomorphine

Purines

Ejaculation

Piperazines

Alprostadil

Papaverine

Nitric Oxide Synthase Type I

Copulation

Sulpiride

Phosphodiesterase Inhibitors

Cyclic Nucleotide Phosphodiesterases, Type 5

Nitric Oxide

Penile Induration

Dopamine Agonists

Orgasm

Libido

Electric Stimulation

Scopolamine Hydrobromide

Pindolol

Muscle, Smooth

Nitric Oxide Synthase

NG-Nitroarginine Methyl Ester

Rats, Sprague-Dawley

Pressure

Nitric oxide release in penile corpora cavernosa in a rat model of erection. (1/478)

Nitric oxide and penile erection in streptozotocin-diabetic rats. (2/478)

Cardiac autonomic function during sleep in psychogenic and organic erectile dysfunction. (3/478)

Selective nitrergic neurodegeneration in diabetes mellitus - a nitric oxide-dependent phenomenon. (4/478)

Effects of sildenafil (Viagra) administration on seminal parameters and post-ejaculatory refractory time in normal males. (5/478)

Diagnostic evaluation of erectile dysfunction. (6/478)

Effects of intracavernous administration of selective antagonists of alpha(1)-adrenoceptor subtypes on erection in anesthetized rats and dogs. (7/478)

Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. (8/478)

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