Peganum
Zygophyllaceae
Harmine
Antinociceptive effects of Peganum harmala L. alkaloid extract on mouse formalin test. (1/7)
PURPOSE: To evaluate the effect of Peganum harmala (Syrian rue) a wild-growing flowering plant belonging to the family Zygophylaceae and found abundantly in Iran on formalin-induced pain response in mice. METHODS: Total alkaloid extract was prepared from dry seeds of Peganum harmala. All doses of extract were dissolved in normal saline and administered intraperitoneally 30 minutes before formalin injection to the mouse paw. Nociception was recorded 0-5 (early phase, A) and 15-40 (late phase, B) minutes after formalin injection. The alkaloid extract was subjected to silica gel column chromatography using a linear gradient with a CHCl3-MeOH system and different fractions collected. The effective fraction in formalin test were further purified and isolated by preparative thin layer chromatography (TLC) and identified on the basis of nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis. RESULTS: Alkaloid extract in doses (mg/kg) used induced significant reduction in pain response when compared to control as follow: 16 (28.63%), 20 (59.15%), 24 (80.75%), 28 (90.14%) and 30 (100%) in the early phase and 20 (24.67%), 24 (59.93%), 28 (78.52%) and 30 (100%) in late phase. Observed responses in both phases of A and B were dose-dependent with r2 of 0.93 and 0.99 respectively. ED50 for phases of A and B were 27.87 and 24.63 mg/kg respectively (p<0.001 for all groups). CONCLUSION: Harmaline, the last step of extraction is the main effective antinociceptive agent of the Peganum harmala alkaloid extract. (+info)Treatment of natural tropical theileriosis with the extract of the plant Peganum harmala. (2/7)
Theileria annulata, a protozoan parasite of cattle and domestic buffaloes, is transmitted by ticks of the genus Hyalomma, and causes a disease named Mediterranean or tropical theileriosis. In this research 50 cattle naturally infected with Theileria annulata were treated with the extract of the plant Peganum harmala. The treatment was continued for 5 days, the dose of the extract being 5 mg/kg per day. After the treatment, 39 cattle responded to the treatment and recovered, but 11 did not respond to the treatment and died. The recovery rate of animals treated with the extract of the plant Peganum harmala was 78%. (+info)Protective effects of estrogens and caloric restriction during aging on various rat testis parameters. (3/7)
(+info)Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression. (4/7)
(+info)Cytotoxic and insecticidal activities of derivatives of harmine, a natural insecticidal component isolated from Peganum harmala. (5/7)
(+info)Recent advances in the studies on luotonins. (6/7)
(+info)Main alkaloids of Peganum harmala L. and their different effects on dicot and monocot crops. (7/7)
(+info)"Peganum" is the name of a genus of plants, specifically those in the family Nitrariaceae. The most well-known species in this genus is "Peganum harmala," also known as Syrian rue or esfand. This plant has been used in traditional medicine in various cultures for its psychoactive and hallucinogenic properties, as well as for treating ailments such as rheumatism, skin conditions, and gastrointestinal disorders. However, it can also have toxic effects and should be used with caution. It's important to note that the use of Peganum in medical treatment is not widely accepted or studied in modern Western medicine.
Harmane, also known as harmaline, is a naturally occurring psychoactive compound found in several plants, including the seeds of the Syrian rue (Peganum harmala) and the bark of the African pinwheel cactus (Adenium obesum). It is an alkaloid with beta-carboline structure.
In a medical context, harmaline has been studied for its potential effects on the central nervous system. It acts as a reversible monoamine oxidase inhibitor (MAOI), which means it can increase the levels of certain neurotransmitters in the brain by preventing their breakdown. This property has led to some research into its use as a treatment for depression and other neurological disorders, although it is not currently approved for medical use in this capacity due to potential side effects and toxicity concerns.
It's important to note that harmaline can have dangerous interactions with certain medications and foods, particularly those containing tyramine, which can lead to a hypertensive crisis. Therefore, its use should only be under the supervision of a qualified medical professional.
Zygophyllaceae is not a medical term, but a taxonomic category in botany. It refers to the family name of a group of flowering plants commonly known as "caltrop family" or "creosote bush family." The plants in this family are primarily found in arid and semi-arid regions worldwide.
Some members of Zygophyllaceae have been used in traditional medicine, but it is essential to note that the use of any plant for medicinal purposes should be done under the guidance of a qualified healthcare professional, as not all plants are safe or effective for treating medical conditions.
Harmine is defined medically as an alpha-carboline derivative that is present in various plants including the seeds of Peganum harmala and the bark of Banisteriopsis caapi. It functions as an monoamine oxidase inhibitor (MAOI) and has been used in traditional medicine for its psychoactive properties. It has also been studied for potential anti-cancer, anti-inflammatory, and neuroprotective effects.
Peganum
Peganum nigellastrum
Peganum harmala
Cannabis tea
Indole alkaloid
List of psychoactive plants
Harmine
Vasicinone
Vasicine
Harmane
List of the vascular plants in the Red Data Book of Russia
Harmala alkaloid
Dehiscence (botany)
Amanita muscaria
Laghouat Province
Iranian jerboa
Nitrariaceae
Zygophyllaceae
Ovary (botany)
Β-Carboline
Religion and drugs
Soma (drink)
East Coast fever
Botanical identity of soma-haoma
Hotson's jerboa
Emmenagogue
Bating (leather)
Athrips falkovitshi
Monoamine oxidase inhibitor
Louisiana State Act 159
Peganum - Wikipedia
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Top-quality Syrian Rue Seeds (Peganum Harmala) | RueShop.com
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Seeds7
- Peganum harmala is also known as "Syrian Rue" seeds. (globalherbs-wholesale.com)
- This product is a highly purified alkaloid extract of Peganum harmala seeds that consists of harmine as tiny freebase crystals/powder. (harmalas.com)
- Many modern day cases for the present day burning of the Peganum harmala seeds are accompanied by the recitation of formulated verses whose content reveals the essential attitude shown towered the plant. (rueshop.com)
- The seeds of Syrian Rue (Peganum harmala) contain the alkaloid harmaline. (k2sheetsshop.com)
- Methods: Hydroalcoholic extract of seeds of Peganum harmala were obtained and screened for anti-mycobacterial activity by disc diffusion (DD) method. (open-foundation.org)
- Taking 3-4 grams of Peganum Harmala seeds can cause hallucinations and stimulant effects. (superpansar.com)
- Serious side effects affecting the nervous system, heart, liver, and kidneys, as well as death, have been reported in people who consumed high amounts of Peganum Harmala seeds. (superpansar.com)
Nitrariaceae4
- Peganum L. is a genus under the recently separated family Nitrariaceae. (wikipedia.org)
- Peganum harmala belongs to Asian origin and grows in the Middle East, parts of South India, Pakistan and west of China and is a medicinal plant of the family Nitrariaceae. (novapublishers.com)
- Peganum harmala , usually called Esfand, is a plant of the family of Nitrariaceae. (ophrp.org)
- Peganum harmala, ordinarily called harmal Syrian rue, esfand, African rue, or harmel, is an everlasting herb , with a woody underground root-stock, of the family Nitrariaceae, normally developing in saline soils in calm desert and Mediterranean areas. (deensquare.com)
Extracts4
- The aim of this study was to evaluate the antimycobacterial and anti-inflammatory activity of the methanolic extracts of Peganum harmala (Esphand) collected from Golestan province, north of Iran. (open-foundation.org)
- The effect of methanol and acetone extracts of the epigeal parts of Peganum harmala, a common medicinal plant among Bedouins in Israel, was studied on several parameters of reproduction in female rats. (tau.ac.il)
- pH-responsive dual-loaded nanoplatforms based on polyamidoamine dendrimer with a hydroxyl-terminated surface (PAMAM-OH), generations 3, 4, and 5 (G3, G4, and G5, respectively), were loaded with Peganum harmala alkaloid extracts (H) and tannic acid (TA) and tested against breast cancer cells. (aucegypt.edu)
- The aqueous extracts of Peganum harmala might have adverse effects on the processes of spermatogenesis due to direct or indirect effects on somniferous tubules and or the pituitary testicular axis. (nel.edu)
Zygophyllaceae1
- Peganum harmala L . (Zygophyllaceae) has been a famous plant in traditional and folk medicine, and it is used in both endemic regions and other parts of the world. (novapublishers.com)
Harmala alkaloids3
- Peganum harmala contains harmala alkaloids such as harmine, harmaline and tetaphydroharmine. (globalherbs-wholesale.com)
- Peganum harmala Alkaloids and Tannic Acid Encapsulated in PAMAM" by Hassan Mohamed El-Said Azzazy, Amany M. Sawy et al. (aucegypt.edu)
- In conclusion, G3 PAMAM-OH dendrimers dually loaded with Peganum harmala alkaloids and tannic acid hold the potential for effective treatment of breast cancer. (aucegypt.edu)
Syrian3
- The genus has around five species, occurring in warm temperate to subtropical regions across the world: Peganum harmala L. (Harmal or Syrian rue) - Mediterranean region east to China Peganum mexicanum Gray - Mexico Peganum multisectum (Maxim. (wikipedia.org)
- Use of Syrian rue (peganum Harmala) is well known in Iran and part of folk medicine. (provithor.com)
- Syrian rue, Peganum harmala, is a plant that since old times is used to increase the effects of psychedelic substances. (k2sheetsshop.com)
Esphand1
- This verse asserts that the use of Peganum Harmala, also known in Iran as Esphand is sanctioned by the most revered sources of religious authority in Islamic Iran. (rueshop.com)
Perennial2
- Peganum harmala is a perennial herbaceous, glabrous plant which can grow 30-100 cm and is mainly disturbed throughout the Middle East, North Africa, and Central Asia. (novapublishers.com)
- Growing from a perennial woody root, Peganum harmala is a bright-green, dense, herbaceous succulent. (entheology.com)
Plants3
- Peganum Harmala acts as an MAO inhibitor, so it can greatly potentiate the effects of magic mushrooms or truffles, as well as allowing one to consume DMT containing plants orally with a tremendous psychedelic effect. (provithor.com)
- Among these medicinal plants, 17 are toxic, the most known being: Daphne gnidium, Nerium oleander, Ferula communis, Peganum harmala and Citrullus colocynthis. (karger.com)
- Hallucinogenic plants have also been used immemorially by tribes in Africa** (Tabernanthe iboga), South America (Banisteria caapi, Peganum harmala, Piptadenia peregrina, etc.), and Asia (Amanita muscaria). (erowid.org)
Inhibitor1
- Peganum harmala is rich source of a variety of reversible mono-amine oxidase inhibitors (MAOIs): harmaline, harmane, harmine, and one seretonin reuptake inhibitor, tetrahydroharmine. (buzzherb.eu)
Ayahuasca1
- In the state of being affected by Peganum Harmala, the body becomes extremely susceptible to any orally consumed DMT, as may be found in the classic ingredients of Ayahuasca brew. (provithor.com)
Psychedelic1
- As for psychedelic use, you may find conflicting information online about the strength and correct use of peganum harmala. (provithor.com)
Iran1
- Also, Peganum harmala was applied as an anti fungal in treatment for many infections in Iran. (ophrp.org)
Effects3
- Histo-functional effects of Peganum harmala on male rat's spermatogenesis and fertility. (nel.edu)
- The Peganum harmala is currently used by the Jordanian populations systemically for its antispasmodic, diuretic, sedative and analgesic effects and externally for its antirheumatic effect. (nel.edu)
- To study effects of Peganum harmala on the reproductive system and fertility using adult male albino rats. (nel.edu)
Doses1
- Peganum Harmala is POSSIBLY UNSAFE when taken by mouth in low doses. (superpansar.com)
Plant1
- Peganum Harmala is a plant that grows in parts of the United States, Asia, Africa, and Europe. (superpansar.com)
Potential1
- These findings revealed the potential ability of the Peganum harmala s seed as a complementary medicine to treat tuberculosis. (open-foundation.org)
China1
- Bobrov - China, Mongolia Peganum nigellastrum Bunge - China Peganum texanum M.E.Jones - southern North America Phylogenetic data suggests the following relationships: Sheahan, M.C. (wikipedia.org)
Body2
- The traditional use of peganum harmala is for abortions and controlled cleansing of the body by throwing up. (provithor.com)
- Group (A) a vehicle-treated control and group (B) a treated group with aqueous extract of Peganum harmala at a dose of 300 mg/kg body weight for 60 days. (nel.edu)
Harmala36
- The genus has around five species, occurring in warm temperate to subtropical regions across the world: Peganum harmala L. (Harmal or Syrian rue) - Mediterranean region east to China Peganum mexicanum Gray - Mexico Peganum multisectum (Maxim. (wikipedia.org)
- Peganum harmala - L. (pfaf.org)
- Peganum harmala is a PERENNIAL growing to 0.6 m (2ft) by 0.5 m (1ft 8in). (pfaf.org)
- Peganum harmala has long been used as a dye plant and was imported into New Mexico in 1928 for "Turkish Red" dye (Guclu and Ozbek 2007). (idseed.org)
- Syrian rue, Peganum harmala, is a plant that since old times is used to increase the effects of psychedelic substances. (organicshroomsusa.com)
- Peganum Harmala is a Mao inibitor. (organicshroomsusa.com)
- The seeds of Syrian Rue (Peganum harmala) contain the alkaloid harmaline. (organicshroomsusa.com)
- It is strongly recommended to do a "MAO diet" at least 12 hours prior to the intake of Peganum harmala. (organicshroomsusa.com)
- Click here for a list of medicines and drugs that should never be used in conjunction with Peganum harmala. (organicshroomsusa.com)
- Syrian Rue (Peganum Harmala) belongs to the family Nitrariaceae. (organicshroomsusa.com)
- How to use peganum harmala seed? (parapsikoloji.net)
- Which nutritions should not be consumed while using peganum harmala seed? (parapsikoloji.net)
- How to prepare peganum harmala seed tea and how to use it? (parapsikoloji.net)
- What are the points you should pay attention while using peganum harmala seed? (parapsikoloji.net)
- For which diseases is peganum harmala seed useful for, are there any benefits or defects of the peganum harmala seed? (parapsikoloji.net)
- Can peganum harmala seed be compared to the Ayahuasca in terms of effects? (parapsikoloji.net)
- Which substances have what kind of effects in the peganum harmala seed? (parapsikoloji.net)
- first, we performed our work with reed grass and peganum harmala seed and then continued with only the use of peganum harmala seeds. (parapsikoloji.net)
- Peganum Harmala , that many people have never heard its name, but known as the Evil Eye Weed in society, really surprised us with its active ingredients, its DMT connection, and its effects. (parapsikoloji.net)
- If every substance that penetrates our body also affects the soul-body contact, we tried to reveal that how positively this influence may be used in Peganum Harmala Seed, Epiphysis and Dmt triangle, what doses can be taken without risking our health, and what are the variations in the innate effects that can be changed individually. (parapsikoloji.net)
- We started to investigate which plants can make a contribution to paranormal studies by testing the effects of plants, particularly the Peganum Harmala Seed and its effects, as an accelerating factor in defeating the wall constructed between ordinary material life and Spirit. (parapsikoloji.net)
- What we publish about the use of peganum harmala seeds is never recommended, treated, or prescribed for. (parapsikoloji.net)
- As a consequence of oral intake of 3 gr of Peganum Harmala seeds, it has been observed to causing of dizziness, nausea, vomiting and central nervous system changes. (parapsikoloji.net)
- It is recorded that the use of long-term or high doses of peganum harmala seeds may cause poisoning, damage to the limb functions and central nervous system. (parapsikoloji.net)
- Can Peganum Harmala Seed Be Used Continuously? (parapsikoloji.net)
- The effect of methanol and acetone extracts of the epigeal parts of Peganum harmala, a common medicinal plant among Bedouins in Israel, was studied on several parameters of reproduction in female rats. (tau.ac.il)
- 11. Inhibition of myeloperoxidase activity by the alkaloids of Peganum harmala L. (Zygophyllaceae). (nih.gov)
- Harmine is an alkaloid found in the seed coats of a plant ( Peganum harmala ) of the Mediterranean region and the Middle East and also in a South American vine ( Banisteriopsis caapi ). (britannica.com)
- Two of the most common are Peganum harmala and Mimosa hostilis, as replacements for the B. caapi vine, and DMT-containing admixture plants, respectively. (ayahuasca.com)
- The herbs of FFMN, such as Peganum harmala L., Glycyrrhiza uralensis Fisch. (bvsalud.org)
- Description Peganum Harmala is also known by many names suc. (naturalether.com)
- Alcaloide aislado de las semillas de PEGANUM HARMALA y ZYGOPHYLLACEAE. (bvsalud.org)
- Peganum harmala L., Zygophyllaceae popularly known as Wild Syrian rue, a well-known plant in folk medicine for many pharmacological uses including antispasmodic activity. (aau.ac.ae)
- Peganum harmala, commonly called esfand (native name), syrian rue, is a plant native to the eastern Iranian region west to India. (gnosticserpent.com)
- Introduction - Seeds of wild Peganum harmala Linn. (westminster.ac.uk)
- Biological Activities of Peganum Harmala Leaves. (nih.gov)
Nigellastrum1
- Bobrov - China, Mongolia Peganum nigellastrum Bunge - China Peganum texanum M.E.Jones - southern North America Phylogenetic data suggests the following relationships: Sheahan, M.C. (wikipedia.org)
Differentiation1
- HPLC fingerprints combined with principal component analysis, hierarchical cluster analysis and linear discriminant analysis for the classification and differentiation of Peganum sp. (westminster.ac.uk)
Distinguish1
- This combination of seed features are recognizable to the genus level, but Peganum species are difficult to distinguish due to the similar seed features within the genus (Amartuvshin et al. (idseed.org)