AnatomyDiseasesChemicals and Drugs
PC12 CellsProprotein Convertase 2Proprotein Convertase 1Proprotein Convertase 5PheochromocytomaProprotein ConvertasesPhosphatidylcholinesNerve Growth FactorNeuritesAdrenal Gland NeoplasmsFurinNeuroendocrine Secretory Protein 7B2Prostatic Neoplasms
PC12 Cells
A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation.
Proprotein Convertase 2
A serine endopeptidase that has specificity for cleavage at ARGININE. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN, proluteinizing-hormone-releasing hormone, proenkephalins, prodynorphin, and PROINSULIN.
Proprotein Convertase 1
A CALCIUM-dependent endopeptidase that has specificity for cleavage at ARGININE that is near paired basic residues. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN; PRORENIN; proenkephalins; prodynorphin; prosomatostatin; and PROINSULIN.
Proprotein Convertase 5
A serine endopeptidase found primarily in the EXTRACELLULAR MATRIX. It has specificity for cleavage of a variety of substrates including PRORENIN, pro-membrane type-1 matrix metalloproteinase, and NEURAL CELL ADHESION MOLECULE L1.
Pheochromocytoma
A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
Proprotein Convertases
Proteolytic enzymes that are involved in the conversion of protein precursors such as peptide prohormones into PEPTIDE HORMONES. Some are ENDOPEPTIDASES, some are EXOPEPTIDASES.
Phosphatidylcholines
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.
Nerve Growth Factor
NERVE GROWTH FACTOR is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons. It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth stimulating activity.
Neurites
In tissue culture, hairlike projections of neurons stimulated by growth factors and other molecules. These projections may go on to form a branched tree of dendrites or a single axon or they may be reabsorbed at a later stage of development. "Neurite" may refer to any filamentous or pointed outgrowth of an embryonal or tissue-culture neural cell.
Adrenal Gland Neoplasms
Tumors or cancer of the ADRENAL GLANDS.
Furin
A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.
Neuroendocrine Secretory Protein 7B2
An acidic protein found in the NEUROENDOCRINE SYSTEM that functions as a molecular chaperone for PROPROTEIN CONVERTASE 2.
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.

The disulfide-bonded loop of chromogranin B mediates membrane binding and directs sorting from the trans-Golgi network to secretory granules. (1/4249)

The disulfide-bonded loop of chromogranin B (CgB), a regulated secretory protein with widespread distribution in neuroendocrine cells, is known to be essential for the sorting of CgB from the trans-Golgi network (TGN) to immature secretory granules. Here we show that this loop, when fused to the constitutively secreted protein alpha1-antitrypsin (AT), is sufficient to direct the fusion protein to secretory granules. Importantly, the sorting efficiency of the AT reporter protein bearing two loops (E2/3-AT-E2/3) is much higher compared with that of AT with a single disulfide-bonded loop. In contrast to endogenous CgB, E2/3-AT-E2/3 does not undergo Ca2+/pH-dependent aggregation in the TGN. Furthermore, the disulfide-bonded loop of CgB mediates membrane binding in the TGN and does so with 5-fold higher efficiency if two loops are present on the reporter protein. The latter finding supports the concept that under physiological conditions, aggregates of CgB are the sorted units of cargo which have multiple loops on their surface leading to high membrane binding and sorting efficiency of CgB in the TGN.  (+info)

Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth. (2/4249)

Ras proteins can activate at least three classes of downstream target proteins: Raf kinases, phosphatidylinositol-3 phosphate (PI3) kinase, and Ral-specific guanine nucleotide exchange factors (Ral-GEFs). In NIH 3T3 cells, activated Ral-GEFs contribute to Ras-induced cell proliferation and oncogenic transformation by complementing the activities of Raf and PI3 kinases. In PC12 cells, activated Raf and PI3 kinases mediate Ras-induced cell cycle arrest and differentiation into a neuronal phenotype. Here, we show that in PC12 cells, Ral-GEF activity acts opposite to other Ras effectors. Elevation of Ral-GEF activity induced by transfection of a mutant Ras protein that preferentially activates Ral-GEFs, or by transfection of the catalytic domain of the Ral-GEF Rgr, suppressed cell cycle arrest and neurite outgrowth induced by nerve growth factor (NGF) treatment. In addition, Rgr reduced neurite outgrowth induced by a mutant Ras protein that preferentially activates Raf kinases. Furthermore, inhibition of Ral-GEF activity by expression of a dominant negative Ral mutant accelerated cell cycle arrest and enhanced neurite outgrowth in response to NGF treatment. Ral-GEF activity may function, at least in part, through inhibition of the Rho family GTPases, CDC42 and Rac. In contrast to Ras, which was activated for hours by NGF treatment, Ral was activated for only approximately 20 min. These findings suggest that one function of Ral-GEF signaling induced by NGF is to delay the onset of cell cycle arrest and neurite outgrowth induced by other Ras effectors. They also demonstrate that Ras has the potential to promote both antidifferentiation and prodifferentiation signaling pathways through activation of distinct effector proteins. Thus, in some cell types the ratio of activities among Ras effectors and their temporal regulation may be important determinants for cell fate decisions between proliferation and differentiation.  (+info)

Identification of a new Pyk2 target protein with Arf-GAP activity. (3/4249)

Protein tyrosine kinase Pyk2 is activated by a variety of G-protein-coupled receptors and by extracellular signals that elevate intracellular Ca2+ concentration. We have identified a new Pyk2 binding protein designated Pap. Pap is a multidomain protein composed of an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal SH3 domain. We demonstrate that Pap forms a stable complex with Pyk2 and that activation of Pyk2 leads to tyrosine phosphorylation of Pap in living cells. Immunofluorescence experiments demonstrate that Pap is localized in the Golgi apparatus and at the plasma membrane, where it is colocalized with Pyk2. In addition, in vitro recombinant Pap exhibits strong GTPase-activating protein (GAP) activity towards the small GTPases Arf1 and Arf5 and weak activity towards Arf6. Addition of recombinant Pap protein to Golgi preparations prevented Arf-dependent generation of post-Golgi vesicles in vitro. Moreover, overexpression of Pap in cultured cells reduced the constitutive secretion of a marker protein. We propose that Pap functions as a GAP for Arf and that Pyk2 may be involved in regulation of vesicular transport through its interaction with Pap.  (+info)

Intracellular sodium modulates the expression of angiotensin II subtype 2 receptor in PC12W cells. (4/4249)

Although the angiotensin II subtype 2 receptor (AT2-R) is expressed abundantly in the adrenal medulla, its physiological significance has not yet been determined. To obtain fundamental knowledge of the regulation of AT2-R expression in the adrenal medulla, we investigated the effects of modulating several ion channels on AT2-R expression in PC12W cells. Experiments were performed after 24 hours of serum depletion under subconfluent conditions. After 48 hours of treatment with various agonists or antagonists, the receptor density and mRNA level of AT2-Rs were quantified by 125I-[Sar1, Ile8]angiotensin II binding and Northern blot analysis. Ouabain (10 to 100 nmol/L) and insulin (10 to 100 nmol/L) dose-dependently increased receptor density and mRNA level. Analysis of the binding characteristics revealed that the ouabain-dependent increase in AT2-R levels was due to an increase in binding capacity without a change in the Kd value. These increases were blocked by lowering the Na+ concentration in the medium. A low concentration of the sodium ionophore monensin (10 nmol/L), the K+-channel blocker quinidine (10 micromol/L), and the ATP-sensitive K+-channel blockers tolbutamide (100 micromol/L) and glybenclamide (10 micromol/L) also significantly increased receptor density, but the ATP-sensitive K+-channel agonist cromakalim (100 micromol/L) decreased receptor density significantly (P<0.01). Nifedipine (10 micromol/L) decreased basal receptor density and completely blocked the increase in receptor density caused by these agents. The increase in receptor density caused by an increase in intracellular Na+ was accompanied by an increase in mRNA level, whereas the ATP-sensitive K+-channel blockers did not change mRNA level. Nifedipine slightly decreased mRNA level. These results suggest that AT2-R expression is sensitively regulated by intracellular cation levels. The change in intracellular Na+ level transcriptionally regulates AT2-R expression, whereas the K+-channel blocker-dependent upregulation appears to be at least in part posttranslational.  (+info)

Hyperoxia induces the neuronal differentiated phenotype of PC12 cells via a sustained activity of mitogen-activated protein kinase induced by Bcl-2. (5/4249)

We previously reported that rat pheochromocytoma PC12 cells express the neuronal differentiated phenotype under hyperoxia through the production of reactive oxygen species (ROS). In the present study, we found that in this phenotype, Bcl-2, an apoptosis inhibitor, affects mitogen-activated protein (MAP)-kinase activity, which is known as a key enzyme of the signal-transduction cascade for differentiation. When PC12 cells were cultured under hyperoxia, a rapid increase in MAP-kinase activity, including that of both p42 and p44, was observed. Although the activity level then decreased quickly, activity higher than the control level was observed for 48 h. PD98059, an inhibitor of MAP kinase, suppressed the hyperoxia-induced neurite extensions, suggesting the involvement of MAP-kinase activity in the mechanism of differentiation induced by ROS. An elevation of Bcl-2 expression was observed after culturing PC12 cells for 24 h under hyperoxia. This Bcl-2 elevation was not affected by treatment with PD98059, suggesting that it did not directly induce neurite extension under hyperoxia. However, the blockade of the Bcl-2 elevation by an antisense oligonucleotide inhibited the sustained MAP-kinase activity and neurite extensions under hyperoxia. Further, in PC12 cells highly expressing Bcl-2, the sustained MAP-kinase activity and neurite extensions under hyperoxia were enhanced. These results suggested that MAP kinase is activated through the production of ROS, and the subsequent elevation of Bcl-2 expression sustains the MAP-kinase activity, resulting in the induction of the neuronal-differentiation phenotype of PC12 cells under hyperoxia.  (+info)

Characterization of elementary Ca2+ release signals in NGF-differentiated PC12 cells and hippocampal neurons. (6/4249)

Elementary Ca2+ release signals in nerve growth factor- (NGF-) differentiated PC12 cells and hippocampal neurons, functionally analogous to the "Ca2+ sparks" and "Ca2+ puffs" identified in other cell types, were characterized by confocal microscopy. They either occurred spontaneously or could be activated by caffeine and metabotropic agonists. The release events were dissimilar to the sparks and puffs described so far, as many arose from clusters of both ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (InsP3Rs). Increasing either the stimulus strength or loading of the intracellular stores enhanced the frequency of and coupling between elementary release sites and evoked global Ca2+ signals. In the PC12 cells, the elementary Ca2+ release preferentially occurred around the branch points. Spatio-temporal recruitment of such elementary release events may regulate neuronal activities.  (+info)

Microvessels from Alzheimer's disease brains kill neurons in vitro. (7/4249)

Understanding the pathogenesis of Alzheimer's disease is of widespread interest because it is an increasingly prevalent disorder that is progressive, fatal, and currently untreatable. The dementia of Alzheimer's disease is caused by neuronal cell death. We demonstrate for the first time that blood vessels isolated from the brains of Alzheimer's disease patients can directly kill neurons in vitro. Either direct co-culture of Alzheimer's disease microvessels with neurons or incubation of cultured neurons with conditioned medium from microvessels results in neuronal cell death. In contrast, vessels from elderly nondemented donors are significantly (P<0.001) less lethal and brain vessels from younger donors are not neurotoxic. Neuronal killing by either direct co-culture with Alzheimer's disease microvessels or conditioned medium is dose- and time-dependent. Neuronal death can occur by either apoptotic or necrotic mechanisms. The microvessel factor is neurospecific, killing primary cortical neurons, cerebellar granule neurons, and differentiated PC-12 cells, but not non-neuronal cell types or undifferentiated PC-12 cells. Appearance of the neurotoxic factor is decreased by blocking microvessel protein synthesis with cycloheximide. The neurotoxic factor is soluble and likely a protein, because its activity is heat labile and trypsin sensitive. These findings implicate a novel mechanism of vascular-mediated neuronal cell death in Alzheimer's disease.  (+info)

Human nerve growth factor beta (hNGF-beta): mammary gland specific expression and production in transgenic rabbits. (8/4249)

Transgenic rabbits carrying gene constructs encoding human nerve growth factor beta (hNGF-beta) cDNA were generated. Expression of hNGF-beta mRNA was restricted to the mammary gland of lactating rabbits. Western Blot analysis revealed a polypeptide of 13.2 kDa in the milk of transgenic animals. hNGF-beta was purified from the milk by a two-step chromatographic procedure. Electrospray mass spectroscopy analysis of purified hNGF-beta depicted a molecular weight of 13,261 Da per subunit. The biological activity of the hNGF-beta was tested using PC12W2 cells and cultures of dorsal root ganglion neurons from chicken embryos. Crude defatted milk from transgenic animals and purified hNGF-beta demonstrated full biological activity when compared to commercial recombinant hNGF-beta.  (+info)

The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells<...The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells<...
TY - JOUR. T1 - The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells. AU - Alyea, Rebecca A.. AU - Laurence, Stephanie E.. AU - Kim, Sung H.. AU - Katzenellenbogen, Benita S.. AU - Katzenellenbogen, John A.. AU - Watson, Cheryl S.. PY - 2008/8. Y1 - 2008/8. N2 - The effects of 17β-estradiol (E2) on dopamine (DA) transport could explain gender and life-stage differences in the incidence of some neurological disorders. We tested the effects of E2 at physiological concentrations on DA efflux in nerve growth factor-differentiated rat pheochromocytoma cells that express estrogen receptors (ER) α, ERβ, and G-protein coupled receptor 30 (GPR30), and DA transporter (DAT). DAT efflux was determined as the transporter-specific loss of 3H-DA from pre-loaded cells; a 9-15 min 10-9 M E2 treatment caused maximal DA efflux. Such rapid estrogenic action suggests a non-genomic response, and an E2-dendrimer conjugate (limited to non-nuclear actions) caused DA ...
https://researchexperts.utmb.edu/en/publications/the-roles-of-membrane-estrogen-receptor-subtypes-in-modulating-do
NGF-differentiated PC12 cells have greater Ca2+ rises i | Open-iNGF-differentiated PC12 cells have greater Ca2+ rises i | Open-i
NGF-differentiated PC12 cells have greater Ca2+ rises in response to depolarization than undifferentiated cells. Peak [Ca2+]cyt for PC12 cells loaded with fura-
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2279173_jgp1310307f05&req=4
Activation of tyrosine kinases by α1A-adrenergic and growth factor receptors in transfected PC12 cells | Biochemical JournalActivation of tyrosine kinases by α1A-adrenergic and growth factor receptors in transfected PC12 cells | Biochemical Journal
We compared the role of tyrosine kinases in α1A-adrenergic receptor (AR) and growth factor receptor stimulation of mitogen-activated protein kinase pathways in PC12 cells. Norepinephrine (NE) (noradrenaline), epidermal growth factor (EGF) and nerve growth factor (NGF) caused different patterns of tyrosine phosphorylation in PC12 cells stably expressing α1A-ARs. NE increased tyrosine phosphorylation of focal adhesion-related kinase Pyk2 and a 70 kDa protein, probably paxillin, whereas EGF strongly stimulated tyrosine phosphorylation of the EGF receptor and cytokine-activated kinase Jak2. The EGF receptor inhibitor AG1478 inhibited activation of extracellular signal-regulated kinases (ERKs) by EGF but not by NE. EGF and NGF strongly activated tyrosine phosphorylation of Shc and caused association of Src-homology collagen (Shc) with growth-factor-receptor-bound protein 2 (Grb2); however, neither NE nor UTP caused substantial activation of the Shc/Grb2 pathway. NE, UTP, EGF and NGF all increased ...
http://www.biochemj.org/content/344/3/889
The Ubiquitin Ligase Praja1 Reduces NRAGE Expression and Inhibits Neuronal Differentiation of PC12 CellsThe Ubiquitin Ligase Praja1 Reduces NRAGE Expression and Inhibits Neuronal Differentiation of PC12 Cells
Evidence suggests that regulated ubiquitination of proteins plays a critical role in the development and plasticity of the central nervous system. We have previously identified the ubiquitin ligase Praja1 as a gene product induced during fear memory consolidation. However, the neuronal function of this enzyme still needs to be clarified. Here, we investigate its involvement in the nerve growth factor (NGF)-induced differentiation of rat pheochromocytoma (PC12) cells. Praja1 co-localizes with cytoskeleton components and the neurotrophin receptor interacting MAGE homologue (NRAGE). We observed an enhanced expression of Praja1 after 3 days of NGF treatment and a suppression of neurite formation upon Praja1 overexpression in stably transfected PC12 cell lines, which was associated with a proteasome-dependent reduction of NRAGE levels. Our data suggest that Praja1, through ubiquitination and degradation of NRAGE, inhibits neuronal differentiation. The two murine isoforms, Praja1.1 and Praja1.2, appear to be
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063067
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Signed-off-by: Igor Mammedov ,[email protected], --- - rebased on top of todays PCI tree to match modified tables --- tests/acpi-test-data/pc/APIC.cpuhp_sparse , Bin 0 -, 160 bytes tests/acpi-test-data/pc/DSDT.cpuhp_sparse , Bin 0 -, 5930 bytes tests/acpi-test-data/pc/SRAT.cpuhp_sparse , Bin 0 -, 264 bytes tests/bios-tables-test.c , 16 ++++++++++++++++ 4 files changed, 16 insertions(+) create mode 100644 tests/acpi-test-data/pc/APIC.cpuhp_sparse create mode 100644 tests/acpi-test-data/pc/DSDT.cpuhp_sparse create mode 100644 tests/acpi-test-data/pc/SRAT.cpuhp_sparse diff --git a/tests/acpi-test-data/pc/APIC.cpuhp_sparse b/tests/acpi-test-data/pc/APIC.cpuhp_sparse new file mode 100644 index 0000000000000000000000000000000000000000..67918d51b7b7fbd26aff57802b3cf358864fb36a GIT binary patch literal 160 zcmXAh%MpMe3`7G13?J,mR)CA1WX6lF*o~!Fij,,*a7f,E&Q5aM,P,xIDtldzrJSv1 z&J,^Gkm&6~&pn)8jo53Ale{s5)($!cstNn)[email protected] B4FLcE literal 0 HcmV?d00001 diff --git a/tests/acpi-test-data/pc/DSDT.cpuhp_sparse ...
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Plus itPlus it
NGF binds to and activates the protein tyrosine kinase gp 140prototrk. Expression of this receptor is required for at least some responses to NGF. Three outstanding issues are addressed in the present work. First, we determined whether expression of gp 140prototrk is required for all neuronal NGF responses. Second, we examined the role of gp 140prototrk in NGF binding and internalization. Third, we addressed the utility of NGF-nonresponsive PC12nnr5 cells for study of the NGF mechanism. In contrast to wild-type PC12 cells, PC12nnr5 cells do not express endogenous gp 140prototrk. We therefore asked whether they possess other defects that compromise NGF signaling pathways. To answer these questions, we transfected PC12nnr5 cells with a cDNA encoding full- length human gp 140prototrk and isolated cell lines permanently expressing the receptor. Introduction of trk rescued all of the many and varied NGF responses assessed, including enhanced protein tyrosine phosphorylation, induction of ...
https://www.jneurosci.org/content/13/7/2919
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Windows 8 has put the worlds PC market to sleep - IDC • The RegisterWindows 8 has put the worlds PC market to sleep - IDC • The Register
The global PC market is dwindling, and Windows 8 could be to blame, according to the beancounters at IDC.. The analyst firm released its rundown of global PC shipments on Tuesday, and the year-on-year double digit decline blows a cold wind for traditional PC makers like Dell and HP, and OS-slinger Microsoft.. It seems clear that the Windows 8 launch not only failed to provide a positive boost to the PC market, but appears to have slowed the market, Bob ODonnell, IDCs program vice president for clients and displays, said in a canned statement.. While some consumers appreciate the new form factors and touch capabilities of Windows 8, the radical changes to the UI, removal of the familiar Start button, and the costs associated with touch have made PCs a less attractive alternative to dedicated tablets and other competitive devices. Microsoft will have to make some very tough decisions moving forward if it wants to help reinvigorate the PC market.. Ouch.. Worldwide PC shipments for the first ...
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Interactions of a neuronal cell line (PC12) with laminin, collagen IV, and fibronectin: identification of integrin-related...Interactions of a neuronal cell line (PC12) with laminin, collagen IV, and fibronectin: identification of integrin-related...
Neuronal responses to extracellular matrix (ECM) constituents are likely to play an important role in nervous system development and regeneration. We have studi
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Segmentation Fault when calling BBSaveState.save test() - www.neuron.yale.edu
from neuron import h h.load_file(stdrun.hoc) pc = h.ParallelContext() pc.gid_clear() pc.set_maxstep(10) section = h.Section() pc.set_gid2node(0, pc.id()) nc = h.NetCon(section(0.5)._ref_v, None, sec=section) nc.threshold = 0 nc.delay = 1 nc.weight[0] = 1 pc.cell(0, nc) pc.setup_transfer() h.stdinit() bbss = h.BBSaveState() pc.psolve(100) bbss.save_test ...
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Red Dead Redemption 2 launch trailer shows off the PC enhancements | PC GamerRed Dead Redemption 2 launch trailer shows off the PC enhancements | PC Gamer
Red Dead Redemption 2 is finally coming to PC next week, but ahead of its arrival you can get a glimpse at the PC enhancements in the launch trailer above. Even on a regular PS4, Red Dead Redemption 2 is a looker, but for our wait we've been rewarded with a flashier version. Rockstar detailed the improvements along with the system requirements earlier in the month, and you can expect increased draw distance, improved tree, grass and fur textures, unlocked resolution and frame rate—there's a lot. Micah Bell in particular looks even more hideous now. I can't turn away. 
https://www.pcgamer.com/red-dead-redemption-2-launch-trailer/
GTN PC Trainer | GarminGTN PC Trainer | Garmin
This PC Trainer simulates the behavior of the GTN/GDU 620 series interface and provides you with a safer environment to learn the basic operation of the system.. Due to its graphic memory, this system must be the only application running on your PC. In some cases, even though your computer meets the minimum PC requirements, the simulator may not function properly. This is due to the unique configuration of each computer and the extra processes and procedures that are utilized by that computer.. ...
https://buy.garmin.com/en-US/digital/p/95993
Specs HP Compaq dx2200 Minitower PC 3.4GHz 651 Mini Tower PC PCs/workstations (BEU376ET1AB)Specs HP Compaq dx2200 Minitower PC 3.4GHz 651 Mini Tower PC PCs/workstations (BEU376ET1AB)
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LG WF-6022PC Product Support :Manuals, Warranty & More | LG AfricaLG WF-6022PC Product Support :Manuals, Warranty & More | LG Africa
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Complete Guide to PC Case Sizes: PC Case Size ComparisonComplete Guide to PC Case Sizes: PC Case Size Comparison
One of the most important decisions that will affect you in the long term is selecting an appropriate PC case among the different PC case sizes. The market se
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New i7 PC ASUS X299-A GTX 1070 G X 8GB | ElaKiriNew i7 PC ASUS X299-A GTX 1070 G X 8GB | ElaKiri
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PC Matic Research Overview | PC Matic TechTalk
Unlike any industry in the history of the world, the PC industry evolves at an incredible pace. At PC Matic, we have been tracking each and every trend
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Spec Ops: The Line PC demo arrives June 19 | ShacknewsSpec Ops: The Line PC demo arrives June 19 | Shacknews
2K has dated the PC demo of Spec Ops: The Line for June 19. The publisher has also revealed the system requirements, and confirmed that itll use Steamworks as DRM.
http://www.shacknews.com/article/73927/spec-ops-the-line-pc-demo-arrives-june-19
How to Play Lineage 2: Revolution on PC - MEmu App PlayerHow to Play Lineage 2: Revolution on PC - MEmu App Player
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No Mans Sky Beyond Patch 2.09.3 Live On PC; Improves Stability And MoreNo Mans Sky Beyond Patch 2.09.3 Live On PC; Improves Stability And More
A new No Mans Sky Beyond patch is live on PC, introducing fixes for a variety of issues. The patch will release on consoles soon
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Japanese translations for pspp packageJapanese translations for pspp package
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http://translationproject.org/PO-files/ja/pspp-0.10.2.ja.po
Cones, H: 13 cm, 160 g, 10 pc | 23863Cones, H: 13 cm, 160 g, 10 pc | 23863
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OriGene - PC (NM 000920) shRNAOriGene - PC (NM 000920) shRNA
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Danstoker Plasma Cutter | DanstokerDanstoker Plasma Cutter | Danstoker
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ViewSonic VPC14-WP Windows Slot-in PC IFP50 seriesViewBoard®
Certified by Intel Unite® for unified communications solution, the ViewSonic® VPC14-WP Windows slot-in PC is the ideal integrated solution for delivering smart whiteboard and smart meeting room functionality on ViewSonic® ViewBoard® interactive flat panel. This slot-in PC module supports high-definition audio and video, and easily plugs into compatible displays. With wireless Wi-Fi dual band and Bluetooth, a powerful Intel® Core™ i5 vPro™ processor, 8GB DDR4 memory (up to 16GB), and a 128GB M.2 SSD storage (up to 256GB), the VPC14-WP contains the computing power needed to operate CPU intensive applications. Connectivity options including 4K DisplayPort, HDMI, VGA, USB 3.0 ports, and Gigabit LAN RJ45 ensure that you stay connected to any and all peripheral devices.
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MSI k7t266 and pc2700 DDRMSI k7t266 and pc2700 DDR
Hello, I am new and got lots of questions? The first one is; I have a k7t266pro mobo from MSI with 256 PC2100 DDR (no name), can I use pc 2700 DDR on this mobo and would I benifit on it by using this ( for ocing?). I also have a T bird 1400, GF MX200 32MB (crap), 30 GB Maxtor
http://www.hardwarecentral.com/showthread.php?131623-MSI-k7t266-and-pc2700-DDR&p=709557
Pc Tune Up(virus?) in ZA Extreme Security - Page 2Pc Tune Up(virus?) in ZA Extreme Security - Page 2
I currently have the Extreme trial version which is so awesome and Im about to purchase the real product soon. I have also downloaded the PC Tune Up software than comes with the package since i wanna try it before the purchase. For some reason tho, after my tune up today, ZA recognized PC Tune UP as a virus called
https://www.zonealarm.com/forums/showthread.php/48794-Pc-Tune-Up
Trusted anti virus for your PC. - Office DepotTrusted anti virus for your PC. - Office Depot
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Download WiseView for PC - Windows 7/8/10 & MAC - AppoCastDownload WiseView for PC - Windows 7/8/10 & MAC - AppoCast
Are you looking to download WiseView for PC? Follow our step-by-step guide to download WiseView for windows and enjoy the app on your pc.
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Hardware, breberka, nebo problém mezi PC a židlí? Děkuji - VIRY.CZ
Dostal se mi do rukou počítač, který vykazuje chyby v komunikaci sítě. Než jsem napsal Vám PC jsem otestoval AV AVAST, jak testem po restartu, tak za provozu OS hloubkovou analýzou - a nic. Doinstaloval jsem aktualizace WIN10, vyčistil, defragmentoval. Prověřil jsem UTP kabel od routru do PC. Stále, ale vykazuje stejné problémy a to ...
https://forum.viry.cz/viewtopic.php?f=13&t=157403
Contact | PC Academy Leyland - 01772 641114
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Building Your First PC? Use These Tips to Avoid Common IssuesBuilding Your First PC? Use These Tips to Avoid Common Issues
Theres nothing quite like powering on a PC that youve assembled, especially considering how much money you saved and PC knowledge you gained during that sweet, sweet bonding time.
https://www.makeuseof.com/tag/building-first-pc-use-tips-avoid-common-issues/
IJMS | Free Full-Text | Electronegative Low-Density Lipoprotein L5 Impairs Viability and NGF-Induced Neuronal Differentiation...IJMS | Free Full-Text | Electronegative Low-Density Lipoprotein L5 Impairs Viability and NGF-Induced Neuronal Differentiation...
There have been striking associations of cardiovascular diseases (e.g., atherosclerosis) and hypercholesterolemia with increased risk of neurodegeneration including Alzheimers disease (AD). Low-density lipoprotein (LDL), a cardiovascular risk factor, plays a crucial role in AD pathogenesis; further, L5, a human plasma LDL fraction with high electronegativity, may be a factor contributing to AD-type dementia. Although L5 contributing to atherosclerosis progression has been studied, its role in inducing neurodegeneration remains unclear. Here, PC12 cell culture was used for treatments with human LDLs (L1, L5, or oxLDL), and subsequently cell viability and nerve growth factor (NGF)-induced neuronal differentiation were assessed. We identified L5 as a neurotoxic LDL, as demonstrated by decreased cell viability in a time- and concentration-dependent manner. Contrarily, L1 had no such effect. L5 caused cell damage by inducing ATM/H2AX-associated DNA breakage as well as by activating apoptosis via lectin-like
http://www.mdpi.com/1422-0067/18/8/1744
Nerve growth factor activates Thy-1 and neurofilament gene transcription in rat PC12 cells - Research - Royal Holloway,...Nerve growth factor activates Thy-1 and neurofilament gene transcription in rat PC12 cells - Research - Royal Holloway,...
The effect of nerve growth factor (NGF) on the expression of neurofilament and Thy-1 genes in rat PC12 pheochromocytoma cells was examined at both the transcriptional and post-transcriptional levels. Addition of NGF to cultured PC12 cells produced increases in mRNAs corresponding to the 68 kd neurofilament protein (NF68) and the Thy-1 glycoprotein within 24 h, with maximal effects of some 90- and 45-fold stimulation (relative to beta-actin mRNA) being observed after 12 and 4 days of treatment, respectively. In addition, transcriptional run-off analyses using isolated nuclei showed that NGF treatment resulted directly in 8- and 4-fold increases in the rate of NF68 and Thy-1 gene transcription. These gene activation events were independent of overt morphological differentiation of PC12 cells occurring both under conditions permissive and non-permissive for neurite outgrowth, and once established the new molecular phenotype was dependent upon the continued presence of NGF. This is the first ...
https://pure.royalholloway.ac.uk/portal/en/publications/nerve-growth-factor-activates-thy1-and-neurofilament-gene-transcription-in-rat-pc12-cells
Transcription Factor for p75NTR | Science SignalingTranscription Factor for p75NTR | Science Signaling
The p75 neurotrophin receptor (p75NTR) is a multifunctional molecule that interacts with various other receptors to control neuronal differentiation, migration, and survival. Pincheira et al. found with a two-hybrid screen with the death domain of p75NTR as bait that the transcription factor Sall2 interacted with the receptor. Sall2 was detected in most regions of the mouse brain and appeared to be present in neurons, not glial cells, where it colocalized with cells expressing p75NTR. Sall2 and p75NTR coimmunoprecipitated from mouse brain lysates, which suggests that the two proteins interacted in vivo. Studies in PC12 cells, a rat pheochromocytoma cell line that responds to nerve growth factor (NGF) and in which both p75NTR and the TrkA neurotrophin receptor are present, showed that under nonstimulated conditions Sall2 and p75NTR interacted and that stimulation with NGF promoted the dissociation of Sall2 from the receptor and its translocation into the nucleus (detected both biochemically and ...
https://stke.sciencemag.org/content/2/57/ec47
Overexpression of Akt inhibits NGF-induced growth arrest and neuronal differentiation of PC12 cells.
To investigate the role of Akt in nerve growth factor (NGF)-induced neuronal differentiation, PC12 cells ectopically expressing wild-type or dominant-inhibitory forms of Akt were analyzed. NGF-induced neurite outgrowth was greatly accelerated in cell
http://www.biomedsearch.com/nih/Overexpression-Akt-inhibits-NGF-induced/11112692.html
The Wnt-1 proto-oncogene regulates MAP kinase activation by multiple growth factors in PC12 cells<...The Wnt-1 proto-oncogene regulates MAP kinase activation by multiple growth factors in PC12 cells<...
TY - JOUR. T1 - The Wnt-1 proto-oncogene regulates MAP kinase activation by multiple growth factors in PC12 cells. AU - Pan, M. G.. AU - Wang, Y. H.. AU - Hirsch, D. D.. AU - Labudda, K.. AU - Stork, P. J.S.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - PC12/Wnt-1 cells display morphological changes in response to stimulation by select growth factors but do not respond to NGF. Furthermore, stimulation by EGF can induce neuronal differentiation in these cells but not in wild type cells. We have found that in these cells, compared to wild type PC12 cells, FGF and EGF stimulation of MAP kinase activity is enhanced, while NGF stimulation of MAP kinase in diminished. Finally, in cells expressing Wnt-1, the effect of cyclic adenosine monophosphate (cAMP) on MAP kinase activation is reversed; cAMP stimulates MAP kinase in wild type PC12 cells but inhibits MAP kinase in PC12/Wnt-1 cells. These data suggest that Wnt-1 expression alters the specificity of growth factor signaling in neuronal cells.. AB - PC12/Wnt-1 ...
https://ohsu.pure.elsevier.com/en/publications/the-wnt-1-proto-oncogene-regulates-map-kinase-activation-by-multi-2
Characterization of Amino Acid Residues Integral to Neuronal Binding o by Nicole C. OlsonCharacterization of Amino Acid Residues Integral to Neuronal Binding o by Nicole C. Olson
Purpose: Alzheimers Disease is a neurodegenerative disease resulting from over-production and neuronal accumulation of amyloid-beta proteins (Aβ40/Aβ42). The glycine residue at position 33 and histidine residues at positions 13 and 14 are involved with binding and internalization of these proteins, actions potentially inhibited by substituting or sterically hindering these residues with an antibody specific to positions 2-11 (IgG-4.1). Rat pheochromocytoma (PC12) cells differentiated with nerve growth factor were used as a neuronal model to determine whether substitution and/or antibody block amyloid-betas neuronal interactions. Methods: PC12 cells were incubated with fluorescein-labeled-amyloid-beta-40 (F-Aβ40) or substituted F-Aβ40 derivatives (F-Aβ40-H13,14G, F-Aβ40-H13,14G;G33A), with or without IgG-4.1. Cells were analyzed by flow cytometry. Results: PC12 cells incubated with F-Aβ40 and IgG-4.1, as well as cells incubated with substituted peptides, exhibit decreased mean fluorescence
https://digitalcommons.calpoly.edu/chemsp/3/
AKT1 Polyclonal Antibody | GoldBioAKT1 Polyclonal Antibody | GoldBio
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011] Product Name ...
https://www.goldbio.com/product/14726/akt1-polyclonal-antibody
Plus itPlus it
he intracellular distribution of 125I-labeled nerve growth factor (NGF) in rat pheochromocytoma PC12 cells was studied by quantitative electron microscopic (EM) autoradiography and by subcellular fractionation. PC12 cells were grown as monolayer cultures in medium supplemented with serum in the presence of 125I-NGF. EM autoradiography showed that 125I-NGF was localized at the plasma membrane and cytoplasmic compartments but did not accumulate in the nuclear chromatin or in the nuclear membrane compartment of cells analyzed after 1 hr and 1, 2, and 8 d of incubation with 125I-NGF. 125I-NGF also was not detected in nuclear subcellular fractions prepared from cells grown in serum-supplemented medium either in suspension for 1 d or in monolayer cultures for 1 to 8 d. In contrast, and in confirmation of the results of Yankner and Shooter (Yankner, B. A., and E. M. Shooter (1979) Pro. Natl. Acad. Sci. U. S. A. 76: 1269-1273), about 60% of the cell-bound 125I-NGF was found in the nuclear pellet after ...
http://www.jneurosci.org/content/2/6/687
BodyBio PC Liquid Phosphatidylcholine, 8 fl ozBodyBio PC Liquid Phosphatidylcholine, 8 fl oz
BodyBio PC Liquid Phosphatidylcholine, 8 fl oz Formulated with a 4:1 Ratio of Omega 6 to Omega 3 in liquid form. Of the tens of thousands of molecules that make up the life of a cell, Phosphatidylcholine (PC) stands apart; probably the most important one of all. BodyBio PC is made of only pure phospholipids which automatically form liposomes in the watery environment of the body, but it goes one important step further… it is also formulated with the essential lipids at a 4:1 ratio. Most PC currently available has an EFA ratio of ~12:1. BodyBio PC not only has a higher concentration of phospholipids, up to 66%, but also maintains EFA concentration at the preferred 4:1 ratio, a BodyBio exclusive. What is BodyBio PC? BodyBio PC is a special, highly concentrated mixture of phospholipids with the highest one being Phosphatidylcholine. The key fact is that PC declines with age and disease. What is the recommended dosage/administration? 1-2 teaspoons per day or as directed by your physician. ...
http://reverse-aging.info/bodybio-pc-liquid-phosphatidylcholine-8-fl-oz/
DOWNLOAD: Pc150lgpDOWNLOAD: Pc150lgp
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A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells | BMC Neuroscience | Full TextA genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells | BMC Neuroscience | Full Text
Glucocorticoids, secreted by the adrenals in response to stress, profoundly affect structure and plasticity of neurons. Glucocorticoid action in neurons is mediated by glucocorticoid receptors (GR) that operate as transcription factors in the regulation of gene expression and either bind directly to genomic glucocorticoid response elements (GREs) or indirectly to the genome via interactions with bound transcription factors. These two modes of action, respectively called transactivation and transrepression, result in the regulation of a wide variety of genes important for neuronal function. The objective of the present study was to identify genome-wide glucocorticoid receptor binding sites in neuronal PC12 cells using Chromatin ImmunoPrecipitation combined with next generation sequencing (ChIP-Seq). In total we identified 1183 genomic binding sites of GR, the majority of which were novel and not identified in other ChIP-Seq studies on GR binding. More than half (58%) of the binding sites contained a GRE.
https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-13-118
Up-regulation of Idh3α causes reduction of neuronal differentiation in PC12 cells<...Up-regulation of Idh3α causes reduction of neuronal differentiation in PC12 cells<...
TY - JOUR. T1 - Up-regulation of Idh3α causes reduction of neuronal differentiation in PC12 cells. AU - Cho, Sun A.. AU - Seo, Min Ji. AU - Ko, Je Yeong. AU - Shim, Jung Hee. AU - Yoo, Jin. AU - Kim, Jung Hee. AU - Kim, Se Yoon. AU - Ryu, Na Kyung. AU - Park, Eun Young. AU - Lee, Han Woong. AU - Lee, Yeon Su. AU - Bahk, Young Yil. AU - Park, Jong Hoon. PY - 2010/5. Y1 - 2010/5. N2 - The PC12 is the widely used cell line to study neuronal differentiation. We had extensively investigated the details of protein expression in differentiated PC12 cells by proteomic analysis. The cells were incubated at the presence of nerve growth factor. We had analyzed the expression changes in the differentiating PC12 cells by 2-dimensional electrophoresis and the identification of the proteins using MALDI-TOF MS. By comparing expression pattern in the time course, we identified the candidate genes which are associated with neuronal differentiation. Among these genes, we performed real-time PCR analysis to ...
https://yonsei.pure.elsevier.com/en/publications/up-regulation-of-idh3%CE%B1-causes-reduction-of-neuronal-differentiati
Fixspyware Virus Removal Guide: Smart PC Fix Removal - How To Remove Smart PC Fix Easily From Your PCFixspyware Virus Removal Guide: Smart PC Fix Removal - How To Remove Smart PC Fix Easily From Your PC
Once inside your computer, Smart PC Fix will program itself to start automatically when you restart your computer. Smart PC Fix will perform computer scanning and will display fake scanning reports which says your computer is infected with Virus and Trojans. Smart PC Fix will also produce many unwanted pop-ups which states your computer is deeply infected with malware and you will be forced to buy the removal software to remove these infections. One thing you should know that this pop-ups and virus scanning reports are all fake. These are some of the usual tricks done by hackers to steal your money. Smart PC Fix rouge program will use most of the computer resources and will make your computer unusable. Manual removal of Smart PC Fix rogue software is not recommended as it involves removing fake entries from computer windows registry. Editing windows registry is only advised for expert users. You should backup your windows registry before editing it. Any unwanted change in registry may result in ...
http://cleanspywarenow.blogspot.com/2013/05/smart-pc-fix-removal-how-to-remove.html
Hybrid PC Market To Grow At A CAGR Of 21.5% From 2014 To 2019 : Latest Report By Radiant Insights,Inc | Tamilnadu Mail
About hybrid PC. A hybrid PC is a 2-in-1 device that functions as a tablet as well as a laptop. Hybrid PC has a detachable screen. Based on the screen size, a hybrid PC is classified into three: 10-12 inches, 12-14 inches, and above 14 inches.. Browse Full Research Report With TOC On Global Hybrid PC Market 2015-2019 at: http://www.radiantinsights.com/research/global-hybrid-pc-market-2015-2019. Covered in this report. The report includes the present scenario and the growth prospects of the global hybrid PC market for the period 2015-2019. To calculate the market size, this report estimates revenue generated from the shipments of hybrid PCs to end-users.. The report covers the Americas, APAC, and EMEA; it also covers the market landscape and its growth prospects in the coming years. The report includes a discussion of the Key vendors operating in this market.. Key regions. • Americas. • APAC. • EMEA. See More Reports of This Category by Radiant ...
http://www.tamilnadumail.in/story/11802/hybrid-pc-market-to-grow-at-a-cagr-of-215-from-2014-to-2019-latest-report-by-radiant-insightsinc.html
fviz cluster(): Visualizing Clusters with PC3 and PC4 - Forum - STHDAfviz cluster(): Visualizing Clusters with PC3 and PC4 - Forum - STHDA
I am using your great package fviz_cluster to visualize my cluster partition object obtained from CLARA over PC1 (dim1) and PC2(dim2). But I want to visualize it with PC3 and PC4 as well. I tried using the argument choose.vars= c(PCA$scores[,Comp.3],PCA$scores[,Comp.4]) where PCA is my princomp object and PCA$scores[,Comp.3] is the PC3 scores for each of my observations in my dataset. However, I get an error message ...
http://www.sthda.com/english/forum/topic-20+fviz_cluster-visualizing-clusters-with-pc3-and-pc4.php
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http://www.nerdkits.com/forum/thread/2526/
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This makes PC12 cells useful as a model system for neuronal differentiation and neurosecretion. Treatment of PC12 cells with ... Wikipedia articles containing the term "PC12 cells" [1] Ras function was partially elucidated using PC12 cell line [2], from ... been studied using this cell line to understand their effects on PC12 cells These types of studies show that use of PC12 cell ... "The PC12 cell as model for neurosecretion: PC12 cells as model for neurosecretion". Acta Physiologica. 192 (2): 273-285. doi: ...
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Bai L, Swayne LA, Braun JE (January 2007). "The CSPalpha/G protein complex in PC12 cells". Biochem. Biophys. Res. Commun. 352 ( ... Cell. 123 (3): 383-96. doi:10.1016/j.cell.2005.09.028. PMID 16269331. S2CID 18173864. Swayne LA, Beck KE, Braun JE (September ... It is also found on secretory vesicles in endocrine, neuroendocrine and exocrine cells. This protein makes up ~1% of the ... 1999). "Mutational analysis of cysteine-string protein function in insulin exocytosis". J. Cell Sci. 112 (9): 1345-51. doi: ...
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Chapman ER, Blasi J, An S, Brose N, Johnston PA, Südhof TC, Jahn R (Aug 1996). "Fatty acylation of synaptotagmin in PC12 cells ... systemic mast cell disease, and a human mast cell leukemia cell line". The Journal of Histochemistry and Cytochemistry. 49 (3 ... O'Regan S, Diebler MF, Meunier FM, Vyas S (Jan 1995). "A Ewing's sarcoma cell line showing some, but not all, of the traits of ... Kimura N, Shiraishi S, Mizunashi K, Ohtsu H, Kimura I (Mar 2001). "Synaptotagmin I expression in mast cells of normal human ...
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LinsidomineLinsidomine
Jang JH, Aruoma OI, Jen LS, Chung HY, Surh YJ (February 2004). "Ergothioneine rescues PC12 cells from beta-amyloid-induced ... It is a metabolite of the antianginal drug molsidomine and acts by releasing NO from the endothelial cells nonenzymatically. It ... Wen TC, Rogido MR, Moore JE, Genetta T, Peng H, Sola A (October 2005). "Cardiotrophin-1 protects cortical neuronal cells ... also hyperpolarizes the cell membrane through influencing the sodium-potassium pump and thereby rendering it less responsive to ...
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BulbocapnineBulbocapnine
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https://en.wikipedia.org/wiki/Bulbocapnine
Sodium- and chloride-dependent glycine transporter 2Sodium- and chloride-dependent glycine transporter 2
2002). "Glycine transporter isoforms show differential subcellular localization in PC12 cells". J. Neurochem. 82 (1): 58-65. ...
https://en.wikipedia.org/wiki/Sodium-_and_chloride-dependent_glycine_transporter_2
Gaseous signaling moleculesGaseous signaling molecules
"Receptor mechanisms mediating cyanide generation in PC12 cells and rat brain". Neurosci Res. 49 (1): 13-18. doi:10.1016/j. ... tissue or cell or are received by the organism, tissue or cell from outside (say, from the atmosphere or hydrosphere, as in the ... Cell Physiology. 304 (2): 207-214. doi:10.1152/ajpcell.00300.2012. PMID 23174561. Tuboly E, Szabó A, Erős G, Mohácsi A, Szabó G ... This effect was shown in lymphocyte cell cultures and in human liver biopsy samples. Nitrous oxide does not bind as a ligand to ...
https://en.wikipedia.org/wiki/Gaseous_signaling_molecules
Tissue plasminogen activatorTissue plasminogen activator
"Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells". Journal of Neurochemistry. 82 (6): 1406-15 ... It is a serine protease (EC 3.4.21.68) found on endothelial cells, the cells that line the blood vessels. As an enzyme, it ... cDNA was cloned into a synthetic plasmid and initially expressed in E. coli cells, followed by yeast cells with successful ... Tissue plasminogen activator also plays a role in cell migration and tissue remodeling.[citation needed] Once in the body, tPA ...
https://en.wikipedia.org/wiki/Tissue_plasminogen_activator
RAB3BRAB3B
Weber E, Jilling T, Kirk KL (March 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". The ... Weber E, Jilling T, Kirk KL (March 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". The ... "Expression and polarized targeting of a rab3 isoform in epithelial cells". The Journal of Cell Biology. 125 (3): 583-94. doi: ... localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells". Journal of Cell Science. 109 ...
https://en.wikipedia.org/wiki/RAB3B
RAB3ARAB3A
Weber E, Jilling T, Kirk KL (March 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". J. ... Cell. 96 (3): 363-74. doi:10.1016/S0092-8674(00)80549-8. PMID 10025402. S2CID 15162326. Jung YJ, Lee TH, Lee JY, Kim JH, Park ... Mol Cell Biol. 15 (3): 1137-43. doi:10.1128/MCB.15.3.1137. PMC 230335. PMID 7532276. "Entrez Gene: RAB3A RAB3A, member RAS ... Cell. Signal. 11 (10): 735-42. doi:10.1016/S0898-6568(99)00037-6. PMID 10574328. Clabecq A, Henry JP, Darchen F (2000). " ...
https://en.wikipedia.org/wiki/RAB3A
Hydrogen cyanideHydrogen cyanide
"Receptor mechanisms mediating cyanide generation in PC12 cells and rat brain". Neuroscience Research. 49 (1): 13-8. doi:10.1016 ... It has also been shown that, while stimulating muscarinic cholinergic receptors in cultured pheochromocytoma cells increases ... shown that neuronal production of HCN activates NMDA receptors and plays a role in signal transduction between neuronal cells ( ...
https://en.wikipedia.org/wiki/Hydrogen_cyanide
RPH3ARPH3A
Weber, E; Jilling T; Kirk K L (March 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". J ... Weber E, Jilling T, Kirk KL (1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". J. Biol. ... "Identification of a rabphilin-3A-interacting protein as GTP cyclohydrolase I in PC12 cells". Biochem. Biophys. Res. Commun. 205 ... Inagaki N, Mizuta M, Seino S (February 1995). "Cloning of a mouse Rabphilin-3A expressed in hormone-secreting cells". J Biochem ...
https://en.wikipedia.org/wiki/RPH3A
Sodium- and chloride-dependent glycine transporter 1Sodium- and chloride-dependent glycine transporter 1
2002). "Glycine transporter isoforms show differential subcellular localization in PC12 cells". J. Neurochem. 82 (1): 58-65. ... Reye P, Penfold P, Pow DV (2001). "Glyt-1 expression in cultured human Müller cells and intact retinae". Glia. 34 (4): 311-5. ... 2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". ... Cytogenet Cell Genet. 71 (3): 211. doi:10.1159/000134110. PMID 7587377. "Entrez Gene: SLC6A9 solute carrier family 6 ( ...
https://en.wikipedia.org/wiki/Sodium-_and_chloride-dependent_glycine_transporter_1
NeuroserpinNeuroserpin
2002). "Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells". J. Neurochem. 82 (6): 1406-15. doi: ... "Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells". J. Neurochem. 82 (6): 1406-15. doi:10.1046/ ...
https://en.wikipedia.org/wiki/Neuroserpin
NAB2NAB2
1998). "The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells". J. Cell Biol. 142 (4): 1075- ... doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573. v t e (Genes on human chromosome 12, Human proteins, All stub ... 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635-48. ... Mol Cell Biol. 16 (7): 3545-53. doi:10.1128/MCB.16.7.3545. PMC 231349. PMID 8668170. Kirsch KH, Korradi Y, Johnson JP (Jul 1996 ...
https://en.wikipedia.org/wiki/NAB2
NorsalsolinolNorsalsolinol
Maruyama Y, Suzuki Y, Kazusaka A, Fujita S (June 2001). "Uptake of the dopaminergic neurotoxin, norsalsolinol, into PC12 cells ... via vesicular monoamine transporter and its secretion by membrane depolarization or purinoceptor stimulation in PC12 cells". ...
https://en.wikipedia.org/wiki/Norsalsolinol
VGFVGF
in an experiment with PC12 cells and its name is non-acronymic. VGF gene encodes a precursor which is divided by proteolysis to ... "Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression". Cell Stem ... and paracrine roles in feedback loops between differentiated glioblastoma cells and glioblastoma-specific cancer stem cells, ... Cell. 22 (4): 514-528.e5. doi:10.1016/j.stem.2018.03.011. PMC 5947947. PMID 29625067. (Genes on human chromosome 7, Proteins, ...
https://en.wikipedia.org/wiki/VGF
SIM2SIM2
Meng, X; Shi, J; Peng, B; Zou, X; Zhang, C (2006). "Effect of mouse Sim2 gene on the cell cycle of PC12 cell". Cell Biology ... When the SIM2 gene is tranfected into PC12 cells, it affects the normal cycle of cell maturation. SIM2 inhibits the expression ... Comparing normal human breast cells to human breast cancer cells with immunohistochemical staining showed that SIM2s was ... which in turn inhibits the cell's ability to pass through the G1/S checkpoint and suppresses the cell's proliferation ability. ...
https://en.wikipedia.org/wiki/SIM2
PPP1R1BPPP1R1B
"Lack of effects of typical and atypical antipsychotics in DARPP-32 and NCS-1 levels in PC12 cells overexpressing NCS-1". ... "Lack of effects of typical and atypical antipsychotics in DARPP-32 and NCS-1 levels in PC12 cells overexpressing NCS-1". ... "Downregulation of the cAMP/PKA pathway in PC12 cells overexpressing NCS-1". Cellular and Molecular Neurobiology. 31 (1): 135-43 ... "Downregulation of the cAMP/PKA pathway in PC12 cells overexpressing NCS-1". Cellular and Molecular Neurobiology. 31 (1): 135-43 ...
https://en.wikipedia.org/wiki/PPP1R1B
NISCHNISCH
August 2003). "IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells". Cell Death and ... Edwards L, Ernsberger P (August 2003). "The I(1)-imidazoline receptor in PC12 pheochromocytoma cells reverses NGF-induced ERK ... a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration". The Journal of Cell Biology. 151 ... In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth ...
https://en.wikipedia.org/wiki/NISCH
PerfluorooctanesulfonamidePerfluorooctanesulfonamide
PFOSA was the most toxic perfluorinated compound in a study with PC12 cells. Concentrations ranged from 10 to 250 micromolar in ... Fields S (June 2008). "Brain Effects Stick Around: PFCs and Neural Cell Development". Environ. Health Perspect. 116 (6): A258. ...
https://en.wikipedia.org/wiki/Perfluorooctanesulfonamide
SYTL4SYTL4
2002). "Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells". J. Biol. Chem. 277 (42): 39673-8. doi: ... "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells ... Cell. 16 (2): 470-82. doi:10.1091/mbc.E04-08-0685. PMC 545880. PMID 15563604. Ross MT, Grafham DV, Coffey AJ, et al. (2005). " ... Cell. Biol. 22 (15): 5518-26. doi:10.1128/MCB.22.15.5518-5526.2002. PMC 133943. PMID 12101244. Fukuda M, Kanno E, Saegusa C, et ...
https://en.wikipedia.org/wiki/SYTL4
Diallyl disulfideDiallyl disulfide
"Protective effect of diallyl disulfide on oxidative stress-injured neuronally differentiated PC12 cells". Molecular Brain ... Diallyl disulfide affects cancer cells much more strongly than normal cells. It also results in a strong and dose-dependent ... Garlic therefore supports, for example, the detoxification function of liver cells in vitro and protects nerve cells from ... The latter is reduced by diallyl disulfide by assisting in the detoxification of the cell, as well as some other mechanisms. By ...
https://en.wikipedia.org/wiki/Diallyl_disulfide
SparassisSparassis
Purified from Sparassis crispa Mediated Neuro-Protection against Glutamate-Induced Toxicity in Differentiated PC12 Cells". Int ... Kim (2012). "Sparassis crispa suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein ...
https://en.wikipedia.org/wiki/Sparassis
Genetically modified food in North AmericaGenetically modified food in North America
Herling DJ, Mintz L, Cohn FG, Popeo PC (12 January 2014). "As Maine Goes, So Goes The Nation? Labeling for Foods Made with ... cell fusion, mutation breeding) or genetic engineering. Canadian law requires that manufacturers and importers submit detailed ...
https://en.wikipedia.org/wiki/Genetically_modified_food_in_North_America
Tyrosylprotein sulfotransferaseTyrosylprotein sulfotransferase
"Tyrosine-O-sulfated proteins of PC12 pheochromocytoma cells and their sulfation by a tyrosylprotein sulfotransferase". J. Biol ... viral cell entrance, and other cell-cell and protein-protein interactions. Selection for specific tyrosine residues requires a ... has generated interest because of its role as the target protein for the viral entrance of HIV into cells. The importance of ...
https://en.wikipedia.org/wiki/Tyrosylprotein_sulfotransferase
Syntrophin, alpha 1Syntrophin, alpha 1
"Multiple effector domains within SNT1 coordinate ERK activation and neuronal differentiation of PC12 cells". J. Biol. Chem. 276 ... "A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface". Mol. Cell. 3 (4 ... Blake DJ (2002). "Dystrobrevin dynamics in muscle-cell signalling: a possible target for therapeutic intervention in Duchenne ... Cell Biol. 150 (6): 1385-98. doi:10.1083/jcb.150.6.1385. PMC 2150701. PMID 10995443. Newey SE, Benson MA, Ponting CP, Davies KE ...
https://en.wikipedia.org/wiki/Syntrophin,_alpha_1
Adapter molecule crkAdapter molecule crk
1995). "v-Crk modulation of growth factor-induced PC12 cell differentiation involves the Src homology 2 domain of v-Crk and ... 1996). "DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane". Mol. Cell. Biol ... alters cell morphology upon translocation to the cell membrane". Mol. Cell. Biol. 16 (4): 1770-6. doi:10.1128/MCB.16.4.1770. ... 1994). "Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- ...
https://en.wikipedia.org/wiki/Adapter_molecule_crk
RAB27ARAB27A
"Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells ... Cell. 13 (5): 1735-49. doi:10.1091/mbc.01-12-0595. PMC 111140. PMID 12006666. Nagashima K, Torii S, Yi Z, Igarashi M, Okamoto K ... Cell. Biol. 22 (6): 1858-67. doi:10.1128/MCB.22.6.1858-1867.2002. PMC 135591. PMID 11865063. Strom M, Hume AN, Tarafder AK, ... Cell. 13 (5): 1735-49. doi:10.1091/mbc.01-12-0595. PMC 111140. PMID 12006666. Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002 ...
https://en.wikipedia.org/wiki/RAB27A
TropoflavinTropoflavin
Han X, Zhu S, Wang B, Chen L, Li R, Yao W, Qu Z (2014). "Antioxidant action of 7,8-dihydroxyflavone protects PC12 cells against ... Cell Press (2015). "Molecule found in tree leaves helps female mice combat weight gain; males unaffected". ScienceDaily. ... "Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids". Cancer Lett. 130 (1-2): 209-16. ... structural requirements for antiproliferative activity on breast cancer cells". Bioorg. Med. Chem. Lett. 11 (24): 3095-7. doi: ...
https://en.wikipedia.org/wiki/Tropoflavin
Long Island MacArthur AirportLong Island MacArthur Airport
On February 3, 2022, a Pilatus PC12 collided with a Hawker 1000 on the ramp. No one was injured. Investigation is still ongoing ... While the airport continues to expand it has added numerous amenities, including free courtesy cell phone parking (located in ... only airport in the tri-state region to offer free wireless Internet service in the entire terminal and in the courtesy cell ...
https://en.wikipedia.org/wiki/Long_Island_MacArthur_Airport
PDE4BPDE4B
"HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3- ... Arp J, Kirchhof MG, Baroja ML, Nazarian SH, Chau TA, Strathdee CA, Ball EH, Madrenas J (Nov 2003). "Regulation of T-cell ... Cytogenetics and Cell Genetics. 69 (1-2): 11-4. doi:10.1159/000133927. PMID 7835077. Bolger GB, Rodgers L, Riggs M (Nov 1994 ... Somatic Cell and Molecular Genetics. 20 (2): 75-86. doi:10.1007/BF02290677. PMID 8009369. S2CID 19182571. McLaughlin MM, ...
https://en.wikipedia.org/wiki/PDE4B
PDE4APDE4A
"HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3- ... Sullivan M, Egerton M, Shakur Y, Marquardsen A, Houslay MD (Sep 1994). "Molecular cloning and expression, in both COS-1 cells ... Zhou L, Thompson WJ, Potter DE (Jul 1999). "Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells" ( ... expressed in Sf9 cells". Archives of Biochemistry and Biophysics. 394 (1): 54-60. doi:10.1006/abbi.2001.2513. PMID 11566027. ...
https://en.wikipedia.org/wiki/PDE4A
Lillian DyckLillian Dyck
Wang, Haitao; Xu, Haiyun; Dyck, Lillian E.; Li, Xin-Min (15 August 2005). "Olanzapine and quetiapine protect PC12 cells from β- ... "Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell ...
https://en.wikipedia.org/wiki/Lillian_Dyck
Mir-221 microRNAMir-221 microRNA
"Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells". FEBS J. 276 (12): 3269-3276. doi:10.1111/j. ... It targets CD117, which then prevents cell migration and proliferation in endothelial cells. miR-221 is known as an anti ... "MicroRNA-221-222 regulate the cell cycle in mast cells". Journal of Immunology. 182 (1): 433-445. doi:10.4049/jimmunol.182.1. ... Cell Biol. 14 (4): 342. doi:10.1038/ncb2484. S2CID 45572115. Yoo BK, Santhekadur PK, Gredler R, Chen D, Emdad L, Bhutia S, ...
https://en.wikipedia.org/wiki/Mir-221_microRNA
3-Deoxyglucosone3-Deoxyglucosone
3DG induces apoptosis in macrophage-derived cell lines and is toxic to cultured cortical neurons and PC12 cells. 3DG induces ... Suzuki K, Koh YH, Mizuno H, Hamaoka R, Taniguchi N (February 1998). "Overexpression of aldehyde reductase protects PC12 cells ... "Induction of apoptotic cell death by methylglyoxal and 3-deoxyglucosone in macrophage-derived cell lines". Biochemical and ... 3DG can be internalized by cells and internalized 3DG is responsible for the production of intracellular oxidative stress. ...
https://en.wikipedia.org/wiki/3-Deoxyglucosone
Lydia Villa-KomaroffLydia Villa-Komaroff
Yankner, BA; Benowitz, LI; Villa-Komaroff, L; Neve, RL (1990). "Transfection of the human GAP-43 gene in PC12 cells: effects on ... The laboratory also discovered direct evidence that the Gap-43 protein was important in the growth of the axons of nerve cells ... After her participation in the landmark research reporting the first synthesis of mammalian insulin in bacterial cells, Villa- ... The American Society for Cell Biology. ascb.org. Retrieved 22 April 2017. "Biography of Lydia Villa-Komaroff". "CEOSE - Member ...
https://en.wikipedia.org/wiki/Lydia_Villa-Komaroff
Valosin-containing proteinValosin-containing protein
... is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells". The Journal of ... Cell. 151 (5): 1042-54. doi:10.1016/j.cell.2012.10.044. PMC 3534965. PMID 23178123. Defenouillère Q, Yao Y, Mouaikel J, Namane ... interacts physically with BRCA1 in the nucleus of living cells". DNA and Cell Biology. 19 (5): 253-63. doi:10.1089/ ... In mammalian cells, p97 is predominantly localized to the cytoplasm, and a significant fraction is associated to membranes of ...
https://en.wikipedia.org/wiki/Valosin-containing_protein
CYTH3CYTH3
... growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells ...
https://en.wikipedia.org/wiki/CYTH3
BTG2BTG2
In fact, in the neuronal PC12 cell line BTG2 is not able to trigger differentiation by itself, but only to synergize with NGF, ... Götz M, Huttner WB (October 2005). "The cell biology of neurogenesis". Nature Reviews Molecular Cell Biology. 6 (10): 777-88. ... B-cell translocation gene 2) and in other mammals by the homologous Btg2 gene. This protein controls cell cycle progression and ... induces neuronal differentiation and prevents apoptosis of terminally differentiated PC12 cells". Oncogene. 21 (44): 6772-78. ...
https://en.wikipedia.org/wiki/BTG2
S100A10S100A10
"Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells". ... P11's involvement with the cytoskeleton may aid the transport of other proteins throughout the cell and to the cell membrane. ... It is found in cell types throughout the body though it is located predominantly in the lungs and kidneys. It is involved in ... On the other hand, when p11 levels decrease, fewer 5-HT1B receptors migrate from inside the neuron to the cell membrane at the ...
https://en.wikipedia.org/wiki/S100A10
Grise FiordGrise Fiord
"Grise Fiord: Wildlife". CTS 2018: It's not easy to bring wireless to the top of the world Competitive cell service coming to ... it is cautioned that only very experienced pilots of Pilatus PC-12, DHC-6 Twin Otter, and DHC-7 aircraft attempt the approach. ...
https://en.wikipedia.org/wiki/Grise_Fiord
PDE4DPDE4D
"HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3- ... These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including ... cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells". ... cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells". ...
https://en.wikipedia.org/wiki/PDE4D
Κ-opioid receptorΚ-opioid receptor
"The cloned kappa opioid receptor couples to an N-type calcium current in undifferentiated PC-12 cells". Neuroscience. 63 (4): ... Lawrence DM, Bidlack JM (September 1993). "The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled ... Src and focal adhesion kinase to stimulate c-Jun N-terminal kinases in transfected COS-7 cells and human monocytic THP-1 cells ... "Mitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: evidence for the involvement of protein kinase C ...
https://en.wikipedia.org/wiki/Κ-opioid_receptor
NeuromyotoniaNeuromyotonia
Moreover, these antibodies have been demonstrated to reduce potassium channel function in neuronal cell lines. Diagnosis is ... "Antibodies to potassium channels of PC12 in serum of Isaacs' Syndrome: Western blot and immunohistochemical studies". Muscle ...
https://en.wikipedia.org/wiki/Neuromyotonia
Dock3Dock3
It has also been shown to regulate neurite outgrowth and cell-cell adhesion in B103 and PC12 cells. The first indication that ... February 2007). "Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells". J. Cell Sci. ... April 1996). "DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane". Mol. Cell ... January 2005). "Modifier of cell adhesion regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth". J. Neurosci ...
https://en.wikipedia.org/wiki/Dock3
List of MeSH codes (A11)List of MeSH codes (A11)
... pc12 cells MeSH A11.251.210.190.880 - u937 cells MeSH A11.251.210.200 - cho cells MeSH A11.251.210.505 - l cells (cell line) ... ht29 cells MeSH A11.251.860.180.495 - jurkat cells MeSH A11.251.860.180.510 - k562 cells MeSH A11.251.860.180.750 - pc12 cells ... l cells MeSH A11.329.228.900 - 3t3 cells MeSH A11.329.228.900.080 - balb 3t3 cells MeSH A11.329.228.900.550 - nih 3t3 cells ... hela cells MeSH A11.251.210.190.400.500 - kb cells MeSH A11.251.210.190.465 - hl-60 cells MeSH A11.251.210.190.475 - ht29 cells ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(A11)
2,6-Dimethoxybenzoquinone2,6-Dimethoxybenzoquinone
... for the Comparison of the Cytotoxicity of 14 p-Benzoquinone Congeners in Primary Cultured Rat Hepatocytes Versus PC12 Cells. ... in V 79 cells. Bollettino della Societa italiana di biologia sperimentale (1988), 64(1), 61-8 Brambilla G; Robbiano L; Cajelli ...
https://en.wikipedia.org/wiki/2,6-Dimethoxybenzoquinone
Western Australia Police ForceWestern Australia Police Force
... in addition to a PC-12 being based at Karratha Airport. The Pilatus PC-12 is a single-engine turbo-prop aeroplane which can ... 6 September 2008 by Emergency Support Group officers from the Department of Corrective Services while being removed from a cell ... for general operations and backup capability Fixed-wing one single-engine GippsAero GA8 Airvan two single-engine Pilatus PC-12 ...
https://en.wikipedia.org/wiki/Western_Australia_Police_Force
PAK1PAK1
... of p21-activated kinase to the membrane is independent of phospholipase C-gamma1 in the differentiation of PC12 cells". ... "PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells ... "SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration". Molecular Cell. 37 (3): 321-32. doi:10.1016/j ... regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells". The Journal of Biological Chemistry. 287 (22 ...
https://en.wikipedia.org/wiki/PAK1
At the Cell Counter: PC-12 Cells | Molecular DevicesAt the Cell Counter: PC-12 Cells | Molecular Devices
It was developed as a model cell line and an alternative to adrenal chromaffin primary cell cultures. ... The PC-12 cells originated from a pheochromocytoma (neuroendocrine tumor) of the rat adrenal medulla. ... Growth curves of PC-12 cells over a ten-day period. Cells were originally seeded at 2000 cells (red), 1000 cells (green), 500 ... It was developed as a model cell line and an alternative to adrenal chromaffin primary cell cultures. PC-12 cells are able to ...
https://www.moleculardevices.com/applications/cell-counting/cell-counter-pc-12-cells
AID 1066499 - Neuroprotective activity against serum-deprivation-induced damage in rat PC12 cells assessed as survival rate at...AID 1066499 - Neuroprotective activity against serum-deprivation-induced damage in rat PC12 cells assessed as survival rate at...
Neuroprotective activity against serum-deprivation-induced damage in rat PC12 cells assessed as survival rate at 10 uM after 48 ...
https://pubchem.ncbi.nlm.nih.gov/bioassay/1066499
Epidermal growth factor-receptor interaction in rat pheochromocytoma (PC12) and human epidermoid A431 cells: Biochemical and...Epidermal growth factor-receptor interaction in rat pheochromocytoma (PC12) and human epidermoid A431 cells: Biochemical and...
... analysis indicated that two different classes of EGF binding sites may be present in PC12 cells. Addition of NGF to PC12 cells ... opposite biological effects in PC12 cells; EGF acts mitogenically, while NGF induces differentiation and causes arrest of cell ... Pheochromocytoma cells (clone PC12) have specific plasmamembrane receptors for both epidermal growth factor (EGF) and nerve ... EGF-receptor interaction in PC12 cells was characterized biochemically by ¹²⁵I-EGF binding studies. EGF binding was ...
https://dspace.library.uu.nl/handle/1874/24641
Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine...Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine...
Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine ... Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine ... OBJECTIVES: We exposed undifferentiated and differentiating neuronotypic PC12 cells to different organophosphates (chlorpyrifos ... Differentiation also worsened the effects of each agent on cell number after prolonged exposure, whereas cell growth was not ...
https://scholars.duke.edu/display/pub691399
CRF and the Urocortins activate NFAT and induce catecholamine production in PC12 cells | ECE2007 | 9th European Congress of...
... in PC12 cells. The transcription factor NFAT (Nuclear Factor of Activated T cells) is activated by calcium, is expressed in ... CRF and the Urocortins activate NFAT and induce catecholamine production in PC12 cells. Erini Dermitzaki , Christos Tsatsanis ... c) The effect of CRF receptor agonists on catecholamine synthesis was abolished by CsA in PC12 cells. In conclusion, our data ... CRF and the Urocortins activate NFAT and induce catecholamine production in PC12 cells (. ...
https://www.endocrine-abstracts.org/ea/0014/abstracts/poster-presentations/1/ea0014p272/
ras isoprenylation is required for ras-induced but not for NGF-induced neuronal differentiation of PC12 cells. | Journal of...ras isoprenylation is required for ras-induced but not for NGF-induced neuronal differentiation of PC12 cells. | Journal of...
... to block p21ras posttranslational modification and membrane association in PC12 cells. Previous ... p21ras from PC12 cell homogenates confirmed that the processed p21ras species is missing from compactin-treated PC12 cells. ... ras isoprenylation is required for ras-induced but not for NGF-induced neuronal differentiation of PC12 cells.. J Cell Biol 1 ... ras isoprenylation is required for ras-induced but not for NGF-induced neuronal differentiation of PC12 cells. M S Qiu, M S Qiu ...
https://rupress.org/jcb/article/115/3/795/55989/ras-isoprenylation-is-required-for-ras-induced-but
Activation of muscarinic receptors in PC12 cells. Stimulation of Ca2+ influx and redistribution<...
Pozzan T, Di Virgilio F, Vicentini LM, Meldolesi J. Activation of muscarinic receptors in PC12 cells. Stimulation of Ca2+ ... Activation of muscarinic receptors in PC12 cells. Stimulation of Ca2+ influx and redistribution. / Pozzan, T.; Di Virgilio, F ... Activation of muscarinic receptors in PC12 cells. Stimulation of Ca2+ influx and redistribution. In: Biochemical Journal. 1986 ... Pozzan, T, Di Virgilio, F, Vicentini, LM & Meldolesi, J 1986, Activation of muscarinic receptors in PC12 cells. Stimulation of ...
https://moh-it.pure.elsevier.com/en/publications/activation-of-muscarinic-receptors-in-pc12-cells-stimulation-of-c
Norwogonin attenuates hypoxia-induced oxidative stress and apoptosis in PC12 cells | BMC Complementary Medicine and Therapies |...Norwogonin attenuates hypoxia-induced oxidative stress and apoptosis in PC12 cells | BMC Complementary Medicine and Therapies |...
We found that norwogonin alleviated hypoxia-induced injury in PC12 cells by increasing the cell viability, reducing LDH release ... we investigated the protective capacity of norwogonin against oxidative damage elicited by hypoxia in PC12 cells. The cell ... Norwogonin attenuates hypoxia-induced injury in PC12 cells by quenching ROS, maintaining the activities of antioxidant enzymes ... In addition, norwogonin prevented cell apoptosis via inhibiting the expression levels of caspase-3, cytochrome c and Bax, while ...
https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-020-03189-8
Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells |...Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells |...
... protecting neuronal PC12 cells against H2O2-induced cytotoxicity. Only the water extracts demonstrated such anti-oxidative ... For this reason, a cell-based assay using neuronal PC12 cell was employed. PC12 cell is a popular study model in analyzing the ... Cell viability test. Cultured PC12 cells in 96-well-plate (5000 cells/well) were pre-treated with various extracts (1 mg/ml) ... Cell culture. Rat pheochromatocytoma PC12 cell line was obtained from ATCC (CRL-1721; USA). The cells were maintained in ...
https://cmjournal.biomedcentral.com/articles/10.1186/1749-8546-5-38
PC-12 Cell Line | Encyclopedia MDPIPC-12 Cell Line | Encyclopedia MDPI
There are two types of PC-12 cell lines, classical PC-12 cells grown in suspension and the adherent line of PC-12 cells ... PC12 Cell Line: Cell Types, Coating of Culture Vessels, Differentiation and Other Culture Conditions. Cells 2020, 9, 958. ... Cell Dev. Biol. 2020, 8, 328. *Grau, C.M.; Greene, L.A. Use of PC12 cells and rat superior cervical ganglion sympathetic ... The immortalized PC-12 cell line demonstrated to be a classical neuronal cell model derived from rat pheochromocytoma with the ...
https://encyclopedia.pub/entry/25216
Fucosyl-GM1 expression and amyloid-β protein accumulation in PC12 cells<...
... of PC12 cells were reactive with Ctxb. However, a detailed biochemical analysis showed that PC12 cells express abundantly a ... of PC12 cells were reactive with Ctxb. However, a detailed biochemical analysis showed that PC12 cells express abundantly a ... of PC12 cells were reactive with Ctxb. However, a detailed biochemical analysis showed that PC12 cells express abundantly a ... of PC12 cells were reactive with Ctxb. However, a detailed biochemical analysis showed that PC12 cells express abundantly a ...
https://augusta.pure.elsevier.com/en/publications/fucosyl-gm1-expression-and-amyloid-%CE%B2-protein-accumulation-in-pc12
Antisense GAP‐43 Inhibits the Evoked Release of Dopamine from PC12 Cells<...Antisense GAP‐43 Inhibits the Evoked Release of Dopamine from PC12 Cells<...
Antisense GAP‐43 Inhibits the Evoked Release of Dopamine from PC12 Cells. / Ivins, Kathryn J.; Neve, Kim A.; Feller, Daniel J. ... Because the expression of antisense GAP‐43 RNA in PC12 cells leads to a decrease in GAP‐43 expression and to the loss of evoked ... Because the expression of antisense GAP‐43 RNA in PC12 cells leads to a decrease in GAP‐43 expression and to the loss of evoked ... Because the expression of antisense GAP‐43 RNA in PC12 cells leads to a decrease in GAP‐43 expression and to the loss of evoked ...
https://ohsu.pure.elsevier.com/en/publications/antisense-gap43-inhibits-the-evoked-release-of-dopamine-from-pc12
Effects of Schwann cell secreted factors on PC12 cell neuritogenesis and survival. - Department of Physiology, Anatomy and...
Schwann cell conditioned media also enhanced PC12 cell survival. Again, in contrast with NGF or SCTM41 cells, the primary ... clear evidence that Schwann cells produce factors other than those already known to stimulate a neural phenotype in PC12 cells ... but this profile was different from either of two cell lines SCTM41 or PVGSCSV40T, or forskolin-expanded Schwann cells. The ... The Schwann cell conditioned medium contains a protein factor (greater than 12 kDa and broken down by trypsin treatment) with ...
https://www.dpag.ox.ac.uk/publications/95124
Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis...Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis...
... these data provide evidence that novel cognitive enhancer noopept protects PC12 cell against deleterious actions of Aβ through ... in PC12 cells. The ability of drug to protect the impairments of cell viability, calcium homeostasis, ROS level, mitochondrial ... Following the exposure of PC12 cells to Аβ 25-35 an increase of the level of ROS, intracellular calcium, and tau ... Noopept treatment before the amyloid-beta exposure improved PC12 cells viability, reduced the number of early and late ...
https://pubmed.ncbi.nlm.nih.gov/25096780/
Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells<...
... and that these miRNAs might contribute to NGF-dependent cell survival in PC12 cells. ... and that these miRNAs might contribute to NGF-dependent cell survival in PC12 cells.", ... and that these miRNAs might contribute to NGF-dependent cell survival in PC12 cells. ... and that these miRNAs might contribute to NGF-dependent cell survival in PC12 cells. ...
https://tohoku.pure.elsevier.com/en/publications/sustained-activation-of-erk12-by-ngf-induces-microrna-221-and-222
MBS9933856 | Mouse Isoprenaline Hydrochloride (ISO-HYD) ELISA Kit | MyBiosourceMBS9933856 | Mouse Isoprenaline Hydrochloride (ISO-HYD) ELISA Kit | MyBiosource
Rat PC12 Whole Cell Lysate , MBS1750992 , MybiosourceProduct Short Name: [PC12]Product Name Synonyme: N/AOther Names: N/ ... PC12 + Pervanadate Lysate , MBS474125 , MybiosourceProduct Short Name: [PC12 + Pervanadate]Product Name Synonyme: N/AOther ... Human Jurkat Whole Cell Lysate , MBS1750982 , MybiosourceProduct Short Name: [Jurkat]Product Name Synonyme: N/AOther Names: N/ ... Human Smmc-7721 Whole Cell Lysate , MBS1750985 , MybiosourceProduct Short Name: [Smmc-7721]Product Name Synonyme: N/AOther ...
https://biocheminfo.org/mbs9933856-mouse-isoprenaline-hydrochloride-iso-hyd-elisa-kit/
KAKEN - Research Projects | Control of cell functions at the tissue level using micro/nanotechnologies (KAKENHI-PROJECT...KAKEN - Research Projects | Control of cell functions at the tissue level using micro/nanotechnologies (KAKENHI-PROJECT...
Journal Article] Three-dimensional co-culture of C2C12/PC12 cells improves skeletal muscle tissue formation and function.2017. ... Journal Article] Three-dimensional co-culture of C2C12/PC12 cells improves skeletal muscle tissue formation and function2015. * ... Also, based on findings on cell functions at the tissue level obtained by the analysis of the organ on a chip, cell delivery ... In order to recapitulate the ocular fundus functions, neural supporting cells such as retinal pigment epithelial (RPE) cells ...
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26286031/
The phosphorylation of Ser<sup>40</sup> of tyrosine hydroxylase has no effect on the stability of the enzyme in PC12...The phosphorylation of Ser<sup>40</sup> of tyrosine hydroxylase has no effect on the stability of the enzyme in PC12...
Although the treatment of rat pheochromocytoma cell line PC12 cells with forskolin increased the amount of TH phosphorylated at ... Although the treatment of rat pheochromocytoma cell line PC12 cells with forskolin increased the amount of TH phosphorylated at ... Although the treatment of rat pheochromocytoma cell line PC12 cells with forskolin increased the amount of TH phosphorylated at ... Although the treatment of rat pheochromocytoma cell line PC12 cells with forskolin increased the amount of TH phosphorylated at ...
https://pure.fujita-hu.ac.jp/en/publications/the-phosphorylation-of-sersup40sup-of-tyrosine-hydroxylase-has-no
Hydroxylation Increases The Neurotoxic Potential Of Bde-47 To Affect Exocytosis And Calcium Homeostasis In Pc12 Cells • MatTek...Hydroxylation Increases The Neurotoxic Potential Of Bde-47 To Affect Exocytosis And Calcium Homeostasis In Pc12 Cells • MatTek...
Hydroxylation Increases The Neurotoxic Potential Of Bde-47 To Affect Exocytosis And Calcium Homeostasis In Pc12 Cells. ...
https://www.mattek.com/reference-library/hydroxylation-increases-the-neurotoxic-potential-of-bde-47-to-affect-exocytosis-and-calcium-homeostasis-in-pc12-cells/
Investigating the Effect of Stable Glutamine on the Neuronal Differentiation of PC-12 Cells in 2D- and 3D-Culture MediaInvestigating the Effect of Stable Glutamine on the Neuronal Differentiation of PC-12 Cells in 2D- and 3D-Culture Media
Pheochromocytoma cells (PC-12), originating from cancerous cells of the rat adrenal gland, are considered as a suitable model ... The cells viabilities were determined and compared between experimental groups using live/dead cell staining by Acridine ... Although, Gln is beneficial for the cells, its degradation produces ammonia which is toxic and negatively affect cell culture. ... Furthermore, cells were stained using cresyl violet to detect neuronal Nissl bodies. The induction of differentiation was ...
https://jcmr.um.ac.ir/article_43039.html
Recognition associated with Dp71 Isoforms Depicted in PC12 Cells: Subcellular Localization and Colocalization along with β...Recognition associated with Dp71 Isoforms Depicted in PC12 Cells: Subcellular Localization and Colocalization along with β...
Characterisation of 5-HT3 recognition sites in membranes of NG 108-15 neuroblastoma-glioma cells with [3H]ICS 205-930 |...Characterisation of 5-HT3 recognition sites in membranes of NG 108-15 neuroblastoma-glioma cells with [3H]ICS 205-930 |...
ICS 205-930 on NG 108-15 cells is very similar to that of the 5-HT3 sites identified on neuroblastoma NlE-115 cells (Hoyer and ... ICS 205-930 recognition sites on NG 108-15 cells. The binding was rapid, stable and reversible. The affinity of [3H]ICS 205-930 ... ICS 205-930 labelling 5-HT3 receptors on NG 108-15 cells. The pharmacological profile of the sites labelled by [3H] ... were investigated in membranes prepared from murine neuroblastoma-glioma NG 108-15 cells.2.[3H]ICS 205-930 bound rapidly, ...
https://www.semanticscholar.org/paper/Characterisation-of-5-HT3-recognition-sites-in-of-Neijt-Karpf/7ccf1b2dde68119212990a5a857d4d6e14ab5b1e
Indian Mulberry | GreenMedInfo | Substance | Natural MedicineIndian Mulberry | GreenMedInfo | Substance | Natural Medicine
Mulberry fruit cultivar Chiang Mai prevents beta-amyloid toxicity in PC12 neuronal cells.Apr 15, 2020. ... Morinda officinalis polysaccharide regulates rat bone mesenchymal stem cell osteogenic-adipogenic differentiation in ...
https://greenmedinfo.com/substance/indian-mulberry
Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation | Cell Death & DiseaseInterleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation | Cell Death & Disease
Mature retinal ganglion cells (RGCs) do not normally regenerate injured axons and undergo apoptosis after axotomy. Inflammatory ... using PC12 cells as positive control. IL-6R was detected in the rat retina and rMC1 cells, but not in peritoneal macrophages ( ... To remove cell fragments or factors released from the cells the cell suspension of one retina was immediately adjusted to a ... Dissociated cells were passed through a cell strainer (40 μm, Falcon) and 300 μl of cell suspension were added into each well ...
https://www.nature.com/articles/cddis2013126?error=cookies_not_supported
WikiGenesWikiGenes
Treatment of PC12 cells with basic fibroblast growth factor (bFGF), a neurotrophic factor for this cell line, did not modify ... We investigated the presence of endooligopeptidase A in PC12 cells. This cell line was derived from a rat pheochromocytoma ... Depending on the supplements added to the cell culture, this cell line can be differentiated into mature chromaffin cell or ... Characterization of an endooligopeptidase A-like protein in PC12 cells: activity modulation by cAMP but not by basic fibroblast ...
https://www.wikigenes.org/e/ref/e/7759568.html
Plus itPlus it
PC12 cells labeled for β-tubulin. E, r-MC1 neural retinal Muller glial cells specifically labeled for GFAP. G, PC12 cells ... PC12) cells. Ultimately, these approaches could be used to visualize and track functional responses in neurons. However, as ... Howarth M, Takao K, Hayashi Y, Ting AY (2005) Targeting quantum dots to surface proteins in living cells with biotin ligase. ... I, An example of artifactual nonspecific labeling in r-MC1 Muller cells with anti-GFAP-conjugated 605 nm quantum dots. In this ...
https://www.jneurosci.org/content/26/7/1893
Fereshteh JAHANBANI | Director of Genomics of Chronic Fatigue Syndrome Research Center at Stanford | PharmD-PhD in Pharmacology...Fereshteh JAHANBANI | Director of Genomics of Chronic Fatigue Syndrome Research Center at Stanford | PharmD-PhD in Pharmacology...
Interaction between cytotoxic effects of Xanthomicrol and Noscapine on PC12 cells. Article ... Cell Type-Specific Chromatin Signatures Underline Regulatory DNA Elements in Human Induced Pluripotent Stem Cells and Somatic ... We generated a genome-wide interaction map of regulatory elements in human cells (ENCODE tier 1 cells, K562, GM12878) using ... Human induced pluripotent stem cells (iPSCs) can be derived from various types of somatic cells by transient overexpression of ...
https://www.researchgate.net/profile/Fereshteh-Jahanbani
Frontiers | FAIM Is a Non-redundant Defender of Cellular Viability in the Face of Heat and Oxidative Stress and Interferes With...Frontiers | FAIM Is a Non-redundant Defender of Cellular Viability in the Face of Heat and Oxidative Stress and Interferes With...
Primary fibroblasts from FAIM-deficient mice showed the same proteostasis deficits as cell lines. Administration of a mediator ... These results identify a completely new actor that protects cells against stress-induced loss of viability by preventing ... Primary fibroblasts from FAIM-deficient mice showed the same proteostasis deficits as cell lines. Administration of a mediator ... These results identify a completely new actor that protects cells against stress-induced loss of viability by preventing ...
https://www.frontiersin.org/articles/10.3389/fmolb.2020.00032/full
Salvia miltiorrhiza alleviates hypoxia-induced nerve injury associated with Ngb/Akt intracellular signaling pathway | Research...Salvia miltiorrhiza alleviates hypoxia-induced nerve injury associated with Ngb/Akt intracellular signaling pathway | Research...
Cell viability analysis. Cytotoxicity was assayed in PC12 cells grown in 96‑well plates. Cells (1.5x105 cells/ml; 0.1 ml per ... Total protein was extracted from brain tissue and PC12 cells according to the instruction. PC12 cells (1.5x105 cells/ml) were ... PC12 cells were plated (1.5x105 cells/ml; 0.1 ml) in 12‑well plates with CoCl2 1mM co‑treated with drug for 24h. Cells were ... Cell culture and treatment. PC12 human neuroblastoma cells were grown in RPMI-1640 supplemented with 15% FBS. Cells were ...
https://www.researchsquare.com/article/rs-56399/v1
Pheochromocytoma cellOutgrowthPresent in PC12 cellsApoptosisDifferentiationDopamine releaseCytotoxicityStimulationProliferationMorphologyViabilityReceptorsNeuritesInducesReactiveProteinsNeurite growthFluorescence MicroscopySurvivalNeurotoxicityNeurotransmitterOxidative stressRatsLineBiologyPhosphorylationNerveC2C12AdrenalAbstractOncogenicBiochemicalNeuron-like cellsNeuroprotective effectPhenotypeAmyloidPretreatmentPolysaccharidesSchwann CellsEnzymeCalciumCytometric analysisTissueTissuesRecombinantExposureNeuronsAccumulationBiologicalMechanismsCellularModulationExtractsApoptoticChromaffinMitochondrial functionLysatesMetabolismEpithelial
Pheochromocytoma cell3
  • In the present study we have examined the effect of CRF peptides on NFAT activation, its role on catecholamine production in the PC12 pheochromocytoma cell line and the signaling pathways involved. (endocrine-abstracts.org)
  • For a rat pheochromocytoma cell line, PC12, which has been used frequently as a model for investigating events leading to neuronal differentiation, it is generally thought that GM1 is a major ganglioside, based on reactivity with the probe cholera toxin B subunit (Ctxb). (elsevier.com)
  • Although the treatment of rat pheochromocytoma cell line PC12 cells with forskolin increased the amount of TH phosphorylated at Ser 40 in the cells, it did not affect the total amount of TH in the cells. (fujita-hu.ac.jp)
Outgrowth6
  • PC-12 cells have been widely used as a neuronal line study model in many biosensing devices, mainly due to the neurogenic characteristics acquired after differentiation, such as high level of secreted neurotransmitter, neuron morphology characterized by neurite outgrowth, and expression of ion and neurotransmitter receptors. (encyclopedia.pub)
  • We have used PC12 cells to examine the effects of factors secreted by Schwann cells that promote cell survival and neurite outgrowth, and hence are likely candidates for promoting neuronal regeneration. (ox.ac.uk)
  • The effects of Schwann cell conditioned media on neurite outgrowth was tested against a range of factors, and showed clear neuritogenic effects. (ox.ac.uk)
  • The ability of drug to protect the impairments of cell viability, calcium homeostasis, ROS level, mitochondrial function, tau phosphorylation and neurite outgrowth caused by Аβ 25-35 were evaluated. (nih.gov)
  • In addition, pretreatment of PC12 cell with noopept significantly attenuated tau hyperphosphorylation at Ser396 and ameliorated the alterations of neurite outgrowth evoked by Аβ25-35. (nih.gov)
  • Tremella fuciformis successfully enhances the neurite outgrowth of PC12 cells and restores trimethyltin-induced impairment of memory in rats ( 18 ). (spandidos-publications.com)
Present in PC12 cells2
  • analysis indicated that two different classes of EGF binding sites may be present in PC12 cells. (uu.nl)
  • However, the phosphorylation of hTH1 at Ser 40 did not affect the amount of the wild-type hTH1 protein present in PC12 cells. (fujita-hu.ac.jp)
Apoptosis11
  • The cell viability and apoptosis were examined by MTT assay and Annexin V-FITC/PI staining, respectively. (biomedcentral.com)
  • In addition, norwogonin prevented cell apoptosis via inhibiting the expression levels of caspase-3, cytochrome c and Bax, while increasing the expression levels of Bcl-2 and the ratio of Bcl-2/Bax. (biomedcentral.com)
  • Norwogonin attenuates hypoxia-induced injury in PC12 cells by quenching ROS, maintaining the activities of antioxidant enzymes, and inhibiting mitochondrial apoptosis pathway. (biomedcentral.com)
  • A recent study also demonstrates that rutin can alleviate cobalt chloride-induced hypoxia damage by inhibiting oxidative stress and apoptosis in H9c2 cell [ 17 ]. (biomedcentral.com)
  • these changes were accompanied by a decrease in cell viability and an increase of apoptosis. (nih.gov)
  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by inhibiting translation and/or inducing degradation of target mRNAs, and they play important roles in a wide variety of biological functions including cell differentiation, tumorigenesis, apoptosis and metabolism. (elsevier.com)
  • Ban K. and Kozar R. A. (2010) Glutamine protects against apoptosis via downregulation of Sp3 in intestinal epithelial cells. (ac.ir)
  • Mature retinal ganglion cells (RGCs) do not normally regenerate injured axons and undergo apoptosis after axotomy. (nature.com)
  • Here we report a new mammalian protein, Fas Apoptosis Inhibitory Molecule (FAIM, also termed FAIM1), that protects cells from cellular stress. (frontiersin.org)
  • The results showed that SE, TanⅡA, and SAS are able to improve biochemical level in high altitude hypoxia mouse model, increase in Ca 2+ concentration, and decrease in MMP, inhibit apoptosis in CoCl 2 -induced PC12 cell hypoxia model by activating Akt signaling pathway, protecting neurons, thus improving the oxygen carrying capacity of brain tissue. (researchsquare.com)
  • Yun HY , Jeong Y . Sedum takesimense Protects PC12 Cells against Corticosterone-Induced Neurotoxicity by Inhibiting Neural Apoptosis. (wjgnet.com)
Differentiation21
  • Due to their differentiation ability and ease of culture, PC-12 cells are used in a variety of research areas ranging from drug efficacy to neurosecretion. (moleculardevices.com)
  • EGF acts mitogenically, while NGF induces differentiation and causes arrest of cell proliferation. (uu.nl)
  • Ni2+) and examined indices of cell replication and differentiation for both short- and long-term exposures. (duke.edu)
  • Differentiation also worsened the effects of each agent on cell number after prolonged exposure, whereas cell growth was not suppressed, nor were there any effects on viability as assessed with trypan blue. (duke.edu)
  • The transcription factor NFAT (Nuclear Factor of Activated T cells) is activated by calcium, is expressed in neuronal tissues and in PC12 cells, and is involved in neuronal cell differentiation. (endocrine-abstracts.org)
  • ras isoprenylation is required for ras-induced but not for NGF-induced neuronal differentiation of PC12 cells. (rupress.org)
  • Induction of neuronal differentiation and ornithine decarboxylase (ODCase) transcription by oncogenic p21N-ras does not occur in compactin-treated cells indicating that activity of oncogenic p21N-ras expressed in PC12 cells is abolished by compactin treatment. (rupress.org)
  • Ca 2+ homoeostasis was investigated in pheochromocytoma neurosecretory (PC12) cells both before and after treatment with nerve growth factor, which induces a neuronal-like differentiation accompanied by a large increase in the number of muscarinic receptors. (elsevier.com)
  • Based on the differentiation time (i.e., about 4 days for PC-12 and 18 for days for SH-SY5Y), and the neurogenic characteristics, PC12 is one of the most preferred cell line to be used as model in neurobiology studies [ 3 ] . (encyclopedia.pub)
  • The immortalized PC-12 cell line demonstrated to be a classical neuronal cell model derived from rat pheochromocytoma with the ability to acquire the sympathetic neurons features in a differentiation process in the presence of nerve growth factor. (encyclopedia.pub)
  • Here we report identification of growth factor-regulated miRNAs using the PC12 cell line, an established model of neuronal growth and differentiation. (elsevier.com)
  • Previous studies showed the importance of Gln in the normal growth and differentiation of the cells. (ac.ir)
  • In the present experimental research, the effect of stable and elevated levels of Gln on the growth and neuronal differentiation of PC-12 cells was compared under 2D- and 3D- (sodium alginate hydrogel beads) culture conditions. (ac.ir)
  • The induction of differentiation was confirmed using immunocytochemical analysis of Nestin and β-tubulin III proteins and Cells' nuclei were counterstained with 4′,6-diamidino-2-phenylindole (DAPI). (ac.ir)
  • Results showed that high concentration of Gln can induce neuronal differentiation in PC-12 cells under both 2D- and 3D- culture conditions and increases the expression of progenitor and mature neuronal markers Nestin and β-tubulin III, respectively. (ac.ir)
  • Chen S., Xia Y., Zhu G., Yan J., Tan C., Deng B., Deng J., Yin Y. and Ren W. (2018) Glutamine supplementation improves intestinal cell proliferation and stem cell differentiation in weanling mice. (ac.ir)
  • PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism. (rochester.edu)
  • Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation. (rochester.edu)
  • The infection of the PC 12 cell line with a retrovirus containing ras-oncogene leads to their neuronal differentiation without the need of nerve growth factor (NGF). (nii.ac.jp)
  • After differentiation by infection with Kirsten-ras murine sarcoma virus, and transplantation to the opposite striatum of the same brain, PC12 cells survive for at least 8 weeks and emit neurites. (nii.ac.jp)
  • PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR , making the line a useful model system for NERVE CELL differentiation. (bvsalud.org)
Dopamine release5
  • In the presence of extracellular calcium, a depolarizing concentration of K + (56 mM) evoked dopamine release from control cells, but not from AS1 and AS2 cells. (elsevier.com)
  • Similarly, the calcium ionophore A23187 evoked dopamine release from control cells, but was ineffective in stimulating dopamine release from AS1 and AS2 cells. (elsevier.com)
  • Because the expression of antisense GAP‐43 RNA in PC12 cells leads to a decrease in GAP‐43 expression and to the loss of evoked dopamine release, these results provide evidence of a role for GAP‐43 in calcium‐dependent neurotransmitter release. (elsevier.com)
  • Abe H., Ino K., Li C.-Z., Kanno Y., Inoue K. Y., Suda A., Kunikata R., Matsudaira M., Takahashi Y. and Shiku H. (2015) Electrochemical imaging of dopamine release from three-dimensional-cultured PC12 cells using large-scale integration-based amperometric sensors. (ac.ir)
  • Effects of polychlorinated biphenyls on dopamine release from PC12 cells. (cdc.gov)
Cytotoxicity3
  • Among various parts of the herb (biennial flower, stem-leaf, root-rhizome, fiber root and sideslip), the water extract of the biennial flower showed the strongest effects in (i) inhibiting the enzymatic activity of xanthine oxidase and (ii) protecting neuronal PC12 cells against H 2 O 2 -induced cytotoxicity. (biomedcentral.com)
  • The live / dead assay confirmed that RSF and I3K have negligible cytotoxicity against PC12 cells. (whiterose.ac.uk)
  • The present study aimed to investigate the protective effect of purified polysaccharides from Tremella fuciformis against glutamate-induced cytotoxicity in differentiated PC12 (DPC12) cells. (spandidos-publications.com)
Stimulation2
  • We found that expression of miR-221 and miR-222 expression were induced by nerve growth factor (NGF) stimulation in PC12 cells, and that this induction was dependent on sustained activation of the extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathway. (elsevier.com)
  • Electromagnetic stimulation increases mitochondrial function in osteogenic cells and promotes bone fracture repair. (rochester.edu)
Proliferation6
  • Glutamine (Gln) is an essential amino acid with a wide range of cellular functions and is necessary for cell proliferation. (ac.ir)
  • In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
  • The peptides were able to self-assemble into nanofibrous structures and interact strongly with silk fibroin (SF) scaffolds, providing a niche for neural cell attachment and proliferation. (whiterose.ac.uk)
  • FK506, one of multiple potent compounds that block T cell proliferation, is used for immunosuppressive therapy. (bdbiosciences.com)
  • Active BMP signaling promoted cell proliferation, migration, and invasion, and sustained survival of MENX rat primary PCC cells. (eur.nl)
  • Treatment of MTT cells with DMH1, a novel BMP antagonist, suppressed proliferation and migration. (eur.nl)
Morphology4
  • Compactin blocked growth factor-induced rapid changes in cell surface morphology but did so whether this response was induced by NGF or by EGF. (rupress.org)
  • We found that norwogonin alleviated hypoxia-induced injury in PC12 cells by increasing the cell viability, reducing LDH release, and ameliorating the changes of cell morphology. (biomedcentral.com)
  • Moreover, neuroprotective properties of noopept likely include its ability to decrease tau phosphorylation and to restore the altered morphology of PC12 cells. (nih.gov)
  • Patterning of I3K peptide nanofibers on RSF surfaces significantly improved cellular attachment, cellular density, as well as morphology of PC12 cells. (whiterose.ac.uk)
Viability6
  • Noopept treatment before the amyloid-beta exposure improved PC12 cells viability, reduced the number of early and late apoptotic cells, the levels of intracellular reactive oxygen species and calcium and enhanced the mitochondrial membrane potential. (nih.gov)
  • Abnosi M., Najafabadi M., Soleimani Mehranjani M., Momeni H. and Safarabadi F. (2010) Preparation of Natural Scaffold from Sciatic Nerve and Viability Evaluation of Seeded Rat Bone Marrow Mesenchymal Stem Cells. (ac.ir)
  • We found that FAIM counteracts heat and oxidative stress-induced loss of cell viability. (frontiersin.org)
  • These results identify a completely new actor that protects cells against stress-induced loss of viability by preventing protein aggregation. (frontiersin.org)
  • Results revealed that TL04 treatment improved cell viability and suppressed reactive oxygen species accumulation, lactose dehydrogenase release and caspase-3 activity, and ameliorated mitochondrial abnormal alteration caused by glutamate. (spandidos-publications.com)
  • The presence of Ac-DEVD-CHO (a caspase-3 inhibitor) markedly enhanced the potency of TL04 in improving the viability of glutamate-exposed DPC12 cells. (spandidos-publications.com)
Receptors5
  • Pheochromocytoma cells (clone PC12) have specific plasmamembrane receptors for both epidermal growth factor (EGF) and nerve growth factor (NGF). (uu.nl)
  • Activation of muscarinic receptors in PC12 cells. (elsevier.com)
  • Dive into the research topics of 'Activation of muscarinic receptors in PC12 cells. (elsevier.com)
  • It is demonstrated that [3H]ICS 205-930 identifies 5-HT3 receptors in preparations of cat and rabbit vagus nerve and superior cervical ganglion and their rank order of affinity for 5- HT3 receptors from neuroblastoma-glioma NG 108-15 cells. (semanticscholar.org)
  • 1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)
Neurites3
  • Atomic force microscopy (AFM) was used to image the topography and neurite formation of PC12 cells, where results revealed that self-assembled I3K nanofibers can support the formation of PC12 cell neurites. (whiterose.ac.uk)
  • Immunolabelling also demonstrated that coating of I3K nanofibers onto the RSF surfaces not only increased the percentage of cells bearing neurites but also increased the average maximum neurite length. (whiterose.ac.uk)
  • These neuron-like cells and their neurites retain tyrosine hydroxylase and choline acetyl transferase, as detected immunohistochemically. (nii.ac.jp)
Induces2
  • We have also shown that CRF induces calcium ion entrance into the cytoplasm from both extracellular sources (influx) and from intracellular stores (mobilization) in PC12 cells. (endocrine-abstracts.org)
  • Nerve growth factor induces 5-HT3 recognition sites in rat pheochromocytoma (PC12) cells. (semanticscholar.org)
Reactive2
  • Flow cytometric analysis with Ctxb revealed that about 30-50% of PC12 cells were reactive with Ctxb. (elsevier.com)
  • Deltamethrin exposure promoted free radical formation in rat brain and reactive oxygen species generation in PC12 cells. (cdc.gov)
Proteins2
  • Immunoblot analysis of proteins from AS1 and AS2 cells indicated that the level of GAP‐43 in these cell lines was reduced. (elsevier.com)
  • FAIM is recruited to ubiquitinated proteins induced by cellular stress and the levels of stress-induced protein aggregates are much greater in FAIM-deficient cell lines. (frontiersin.org)
Neurite growth2
  • As micro-patterning of neural cells to guide neurite growth is important for developing nerve tissue engineering scaffolds, inkjet printing was used to pattern self-assembled I3K peptide nanofibers on RSF surfaces for directional control of PC12 cell growth. (whiterose.ac.uk)
  • [7] [8] Pregnenolone was found to induce tubule polymerization in neuronal cultures and to increase neurite growth in PC12 cells treated with nerve growth factor . (wikipedia.org)
Fluorescence Microscopy1
  • Using Mini202, we measured the pH of catecholamine secretory vesicles in PC-12 cells (pH ≈ 5.9) via two-photon fluorescence microscopy. (columbia.edu)
Survival4
  • Effects of Schwann cell secreted factors on PC12 cell neuritogenesis and survival. (ox.ac.uk)
  • Schwann cell conditioned media also enhanced PC12 cell survival. (ox.ac.uk)
  • These results reveal that the ERK signal regulates miR-221/222 expression, and that these miRNAs might contribute to NGF-dependent cell survival in PC12 cells. (elsevier.com)
  • Extensive research on the effects of green tea has suggested that this natural product, which is used in so many cultures, in so many different ways, shows that the neuroprotective/neurodegenerative effects of green tea catechins not only act as antioxidants metal chelators, but also as modulators of intracellular neuronal signaling and metabolism, cell survival/death genes, and mitochondrial function. (wehaveparkinsons.com)
Neurotoxicity3
  • Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel. (duke.edu)
  • CONCLUSIONS: These studies point out the feasibility of developing cell-based screening methods that enable the detection of multiple end points that may relate to mechanisms associated with developmental neurotoxicity, revealing some common targets for disparate agents. (duke.edu)
  • Zhang Y , He Y , Deng N , Chen Y , Huang J , Xie W . Protective Effect of Resveratrol Against Corticosterone-induced Neurotoxicity in PC12 Cells. (wjgnet.com)
Neurotransmitter1
  • Abstract: To investigate the role of the neuronal growth‐associated protein GAP‐43 (neuromodulin, B‐50, F1, P‐57) in neurotransmitter release, we transfected PC12 cells with a recombinant expression vector coding for antisense human GAP‐43 cRNA. (elsevier.com)
Oxidative stress1
  • Nevertheless, differentiating cells displayed signs of oxidative stress from all of the test compounds except Ni2+, as evidenced by measurements of lipid peroxidation. (duke.edu)
Rats2
  • We find that neoplastic, naive PC12 cells grafted to the striatum of normal adult rats cause the transient formation of large hemorrhagic cavities and do not survive. (nii.ac.jp)
  • Chronic exposure of rats resulted in increased thyroid follicular cell tumors from sustained perturbation of thyroid hormone homeostasis. (cdc.gov)
Line7
  • It was developed as a model cell line and an alternative to adrenal chromaffin primary cell cultures. (moleculardevices.com)
  • In this study, we have reevaluated GM1 expression and Ctxb reactivity in PC12 cells and a subcloned line, PC12D cells. (elsevier.com)
  • Because it has been claimed that amyloid-β protein (Aβ) interacts with GM1 in PC12 cells to provide "seeding" for amyloid to accumulate, we further evaluated this possibility and found that Aβ is mostly likely interacting with fucosyl-GM1 in this cell line. (elsevier.com)
  • No PrP TSE or infectivity has been detected in any exposed cell line under study so far. (cdc.gov)
  • Flow cytometric analysis of Jurkat cells using HSP90 (C45G5) Rabbit mAb (solid line) compared to concentration-matched Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900 (dashed line). (cellsignal.com)
  • A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA . (bvsalud.org)
  • No PrPTSE or vCJD infections have been transmitted by transfusions of infectivity has been detected in any exposed cell line under nonleukoreduced erythrocyte concentrates and by a human- study so far. (cdc.gov)
Biology3
  • Providing our customers with innovative bioanalytical solutions for protein and cell biology for over 30 years. (moleculardevices.com)
  • With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm. (lidsen.com)
  • Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials. (lidsen.com)
Phosphorylation1
  • Collectively, these results indicate the fact that the phosphorylation of Ser 40 does not affect the stability of TH protein in PC12 cells. (fujita-hu.ac.jp)
Nerve2
  • PC-12 cells are able to differentiate into neuron-like cells in the presence of nerve growth factor or dexamethasone. (moleculardevices.com)
  • The results demonstrated that inkjet-printed peptide micro-patterns can effectively guide the cell alignment and organization on RSF scaffold surfaces, providing great potential for nerve regeneration applications. (whiterose.ac.uk)
C2C122
  • Journal Article] Three-dimensional co-culture of C2C12/PC12 cells improves skeletal muscle tissue formation and function. (nii.ac.jp)
  • Western blot analysis of extracts from HeLa, C2C12, C6 and COS cells using HSP40 (C64B4) Rabbit mAb. (cellsignal.com)
Adrenal3
  • First cultured by Greene and Tischler in 1976, PC-12 cells originated from a pheochromocytoma (neuroendocrine tumor) of the rat adrenal medulla. (moleculardevices.com)
  • We have previously shown that Corticotropin releasing factor (CRF) and Urocortins (UCNs) induce the production of catecholamines from normal human and rat adrenal chromaffin and PC12 pheochomocytoma cells via induction of tyrosine hydroxylase, the rate limiting enzyme of catecholamine biosynthesis. (endocrine-abstracts.org)
  • Pheochromocytoma cells (PC-12), originating from cancerous cells of the rat adrenal gland, are considered as a suitable model to study the differentiating effects of different factors. (ac.ir)
Abstract1
  • abstract = "Gangliosides, sialic acid-containing glycosphingolipids, are ubiquitously expressed in all eukaryotic cells and are localized primarily in the plasma membrane. (elsevier.com)
Oncogenic2
  • BMP7 is a growth factor playing pro- or anti-oncogenic roles in cancer in a cell type-dependent manner. (eur.nl)
  • Silencing integrin ß1 in PC12 cells suppressed BMP7-mediated oncogenic features. (eur.nl)
Biochemical2
  • From a series of biochemical studies, however, it has been reported that no GM1 is expressed in PC12 cells. (elsevier.com)
  • However, a detailed biochemical analysis showed that PC12 cells express abundantly a different ganglioside, fucosyl-GM1, instead of GM1, and the reactivity of Ctxb in the PC12 cells actually arose from its interaction with fucosyl-GM1, which also interacts with this ligand. (elsevier.com)
Neuron-like cells1
  • On the other hand, neuronal cell lines are commonly used for in vitro neurobiology studies because they are easily transfected, possess the ability to proliferate, and can be induced to differentiate into neuron-like cells, expressing neuronal biomarkers and presenting axons and dendrites. (encyclopedia.pub)
Neuroprotective effect2
  • The neuroprotective effect of noopept (added to the medium at 10 μM concentration, 72 hours before Аβ 25-35) was studied on Аβ 25-35-induced injury (5 μM for 24 h) in PC12 cells. (nih.gov)
  • Collectively, the results demonstrated that the purified polysaccharides separated from Tremella fuciformis (TL04) possess a neuroprotective effect against glutamate-induced DPC12 cell damage predominantly through the caspase-dependent mitochondrial pathway. (spandidos-publications.com)
Phenotype2
  • Finally, all of the toxicants shifted the transmitter fate of the cells away from the cholinergic phenotype and toward the catecholaminergic phenotype. (duke.edu)
  • Our results provide clear evidence that Schwann cells produce factors other than those already known to stimulate a neural phenotype in PC12 cells, and which thus have potential regeneration enhancing effects. (ox.ac.uk)
Amyloid1
  • Our data thus suggest that a specific interaction may occur between Aβ and fucosyl-GM1 for the accumulation of amyloid in PC12 cells. (elsevier.com)
Pretreatment1
  • TL04 pretreatment enhanced the level of B‑cell lymphoma 2 (Bcl‑2), and suppressed Bax expression and cytochrome c (Cyto C) release in glutamate-treated cells. (spandidos-publications.com)
Polysaccharides1
  • Wang L , Li K, Cui Y, Peng H, Hu Y, Zhu Z. Preparation, structural characterization and neuroprotective effects to against H2O2-induced oxidative damage in PC12 cells of polysaccharides from Pleurotus Ostreatus. (wjgnet.com)
Schwann Cells3
  • RT-PCR showed that primary Schwann cells produced a range of neurotrophins, excluding NT3, but this profile was different from either of two cell lines SCTM41 or PVGSCSV40T, or forskolin-expanded Schwann cells. (ox.ac.uk)
  • Western blotting for neurofilaments showed that primary Schwann cells induced a strong response close to that of NGF. (ox.ac.uk)
  • The Trk tyrosine kinase inhibitor K252a did not block the neuritogenic effects of primary Schwann cells. (ox.ac.uk)
Enzyme1
  • A biosensor is a device that transforms chemical information into an analytically useful signal and contain two connected components: a receptor, consisting in a recognition system (antibody, enzyme, aptamer, cell, etc.,), and a physicochemical transducer. (encyclopedia.pub)
Calcium4
  • Taken together, these data provide evidence that novel cognitive enhancer noopept protects PC12 cell against deleterious actions of Aβ through inhibiting the oxidative damage and calcium overload as well as suppressing the mitochondrial apoptotic pathway. (nih.gov)
  • Duman JG, Chen L, Hille B (2008) Calcium transport mechanisms of PC12 cells. (yale.edu)
  • The current hypothesis suggests that the peptidoglycans are transported across the gut wall through specialized uptake cells because they are encased in a calcium-phosphate matrix. (open.ac.uk)
  • Following their transport across the gut wall, the peptidoglycan/calcium-phosphate nanoparticles are endocytosed by white blood cells that consequently express a death receptor ligand. (open.ac.uk)
Cytometric analysis1
  • Flow cytometric analysis of HeLa cells using HSP60 (D6F1) XP ® Rabbit mAb (blue) compared to concentration-matched Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900 (red). (cellsignal.com)
Tissue8
  • Also, based on findings on cell functions at the tissue level obtained by the analysis of the organ on a chip, cell delivery therapy was investigated. (nii.ac.jp)
  • In order to recapitulate the ocular fundus functions, neural supporting cells such as retinal pigment epithelial (RPE) cells were cultured within a three-dimensional microfluidic device, and cell responses at the tissue level to changes in the microenvironment were analyzed. (nii.ac.jp)
  • Also, the obtained results were applied to control the tissue functions of RPE cells cultured on the polymeric nanosheets, which was extended to a method to deliver an RPE sheet into the subretinal space. (nii.ac.jp)
  • These common diseases are closely related to tissue or cell hypoxia. (researchsquare.com)
  • Guiding neuronal cell growth is desirable for neural tissue engineering but is very challenging. (whiterose.ac.uk)
  • Therefore, the peptide I3K could be used as an alternative to poly-l-lysine for cell culture and tissue engineering applications. (whiterose.ac.uk)
  • It has become clear, however, that the susceptibility of cells to infection with TSE agents cannot be reliably predicted either from their tissue of origin or level of expression of PrP C ( 11 , 12 ). (cdc.gov)
  • The goal is optimise the strutcure of the material to support mesenchymal stem cell pro-angiogenic and immuno-modulatory function for dermal and connective tissue reconstruction of chronic ulcers. (open.ac.uk)
Tissues1
  • Organisms are able to recover from injuries by replacing damaged tissues, which recover by replacing damaged cells and extracellular structures. (intechopen.com)
Recombinant1
  • Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)
Exposure2
  • RESULTS: In undifferentiated cells, all the agents inhibited DNA synthesis, with the greatest effect for diazinon, but physostigmine eventually produced the largest deficits in the total number of cells after prolonged exposure. (duke.edu)
  • Exposure to carbachol induced modest, but long-lasting, [Ca 2+ ](i) rises, which were faster and greater in differentiated than in non-differentiated cells. (elsevier.com)
Neurons2
  • The neurons are kept healthy by other cells of the brain, which are closely connected, and miscommunications in one area can disrupt other brain activities, meaning that brain disorders can result in widespread problems. (encyclopedia.pub)
  • Neuronal cells establishing from cell lines can offer a well-characterized source of cells for transplantation to the brain that is an alternative to fetal neurons. (nii.ac.jp)
Accumulation1
  • All cell lines we studied resisted between accumulation of PrPTSE and the development infection with 3 TSE agents, including the BSE agent. (cdc.gov)
Biological2
  • The objective of this study was to determine the potential susceptibility to infection of 5 cell lines used or proposed for manufacture of biological products, as well as other lines. (cdc.gov)
  • PrPC is a susceptibility to infection of 5 cell lines used or proposed for nonessential protein but, at least in mice and cows, must be manufacture of biological products, as well as other lines. (cdc.gov)
Mechanisms2
  • In this regard, the (bio)sensors field represent an excellent tool recognized for fast, low-cost, and innovative methodologies that can be designed for in situ analysis of cell cultures, improving in vitro models, thus allowing the study of molecular mechanisms to be carried out in a simple and reproducible manner [ 4 ] . (encyclopedia.pub)
  • In this study, we investigated the neuroprotective action of noopept on cellular model of AD, Aβ 25-35-induced toxicity in PC12 cells and revealed the underlying mechanisms. (nih.gov)
Cellular1
  • In order to obtain detailed information on the mechanism of intra- or extra-cellular reactions involving cells under different stimuli, mimicking different pathophysiological processes, an appropriate analytical approach is needed. (encyclopedia.pub)
Modulation2
  • Characterization of an endooligopeptidase A-like protein in PC12 cells: activity modulation by cAMP but not by basic fibroblast growth factor. (wikigenes.org)
  • OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches - including gene therapy, cell therapy, and epigenetic modulation - will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. (lidsen.com)
Extracts5
  • Western blot analysis of extracts from various cell lines using HSP60 (D6F1) XP ® Rabbit mAb. (cellsignal.com)
  • Western blot analysis of extracts from PANC1, HepG2 and A204 cells using Calnexin (C5C9) Rabbit mAb. (cellsignal.com)
  • Western blot analysis of extracts from various cell types using PDI (C81H6) Rabbit mAb. (cellsignal.com)
  • Western blot analysis of extracts from HeLa, NIH/3T3, C6 and COS cells, using HSF1 antibody. (cellsignal.com)
  • Western blot analysis of extracts from HeLa, NIH/3T3, PC12 and COS cells using HSP90 (C45G5) Rabbit mAb. (cellsignal.com)
Apoptotic1
  • Experiments demonstrate that the reduction of mitochondrial membrane potential (MMP, Δψ m) leads to the release of cytochrome c (Cyto C), whose cytoplasmic localization initiates caspase-dependent apoptotic cell death. (spandidos-publications.com)
Chromaffin1
Mitochondrial function1
  • B-cell lymphoma 2 (Bcl-2) and Bax, located in the mitochondria, are considered to be associated with mitochondrial function ( 7 ). (spandidos-publications.com)
Lysates1
  • WB: PC-12 and SH-SY5Y cell lysates. (abcam.com)
Metabolism1
Epithelial1
  • Thus, ras-primed PC12 cells may serve as a continuous source for both cholinergic and dopaminergic transmitters, in vivo, without the need of exogenous NGF.In addition to the PC 12 cell lines, we also find that rat amniotic epithelial cells can be differentiated to neuronal cells, thus these cells also may be useful for neuronal transplantation as a non-neoplastic candidate. (nii.ac.jp)
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Indian Mulberry | GreenMedInfo | Substance | Natural Medicine (greenmedinfo.com)
Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation | Cell Death & Disease
Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation | Cell Death & Disease (nature.com)
WikiGenes
WikiGenes (wikigenes.org)
Plus it
Plus it (jneurosci.org)
Glutathione peroxidase activity is neuroprotective in models of Huntington's disease | Nature Genetics
Glutathione peroxidase activity is neuroprotective in models of Huntington's disease | Nature Genetics (nature.com)
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Frontiers | Visualization of SNARE-Mediated Hemifusion between Giant Unilamellar Vesicles Arrested by Myricetin (frontiersin.org)
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Index by author - July 01, 1999, 19 (13) | Journal of Neuroscience
Index by author - July 01, 1999, 19 (13) | Journal of Neuroscience (jneurosci.org)
(researchgate.net)
Blood Brain Barrier | GreenMedInfo | Keyword | Natural Medicine
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Purified Mouse Anti-FKBP65
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Cooperative inhibition of SNARE-mediated vesicle fusion by α-synuclein monomers and oligomers | Scientific Reports
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Plus it
Plus it (jneurosci.org)
IJERPH | Free Full-Text | Nonylphenol Toxicity Evaluation and Discovery of Biomarkers in Rat Urine by a Metabolomics Strategy...
IJERPH | Free Full-Text | Nonylphenol Toxicity Evaluation and Discovery of Biomarkers in Rat Urine by a Metabolomics Strategy... (mdpi.com)
Plus it
Plus it (jneurosci.org)
The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology | Scientific Reports
The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology | Scientific Reports (nature.com)
MicrocircuitDB: Citation Relationship
MicrocircuitDB: Citation Relationship (senselab.med.yale.edu)
Frontiers | Multiple Roles in Neuroprotection for the Exercise Derived Myokine Irisin
Frontiers | Multiple Roles in Neuroprotection for the Exercise Derived Myokine Irisin (frontiersin.org)
Biomolecules | Free Full-Text | Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts
Biomolecules | Free Full-Text | Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts (mdpi.com)
Plus it
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Neurology - Research output - Mayo Clinic
Neurology - Research output - Mayo Clinic (mayoclinic.pure.elsevier.com)
RePub, Erasmus University Repository: Oncogenic features of the bone morphogenic protein 7 (BMP7) in pheochromocytoma
RePub, Erasmus University Repository: Oncogenic features of the bone morphogenic protein 7 (BMP7) in pheochromocytoma (repub.eur.nl)
Pregnenolone - Wikipedia
Pregnenolone - Wikipedia (en.wikipedia.org)
EcologyNews.com
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Mangostán: MedlinePlus suplementos (medlineplus.gov)