Patients polymyositis. Medical search

Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)

A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)

Inflammation of a muscle or muscle tissue.

An enzyme that activates histidine with its specific transfer RNA. EC 6.1.1.21.

A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.

Progressive myopathies characterized by the presence of inclusion bodies on muscle biopsy. Sporadic and hereditary forms have been described. The sporadic form is an acquired, adult-onset inflammatory vacuolar myopathy affecting proximal and distal muscles. Familial forms usually begin in childhood and lack inflammatory changes. Both forms feature intracytoplasmic and intranuclear inclusions in muscle tissue. (Adams et al., Principles of Neurology, 6th ed, pp1409-10)

A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.

Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.

Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.

In patients with neoplastic diseases a wide variety of clinical pictures which are indirect and usually remote effects produced by tumor cell metabolites or other products.

A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.

Contractile tissue that produces movement in animals.

A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.

A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.

A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.

Myoglobinuria is the presence of myoglobin, a protein found in muscle fibers, in the urine, which can occur due to muscle injury or disease, and may lead to acute kidney injury if excessive.

Experimental animal models for human AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM. They include GUILLAIN-BARRE SYNDROME (see NEURITIS, AUTOIMMUNE, EXPERIMENTAL); MYASTHENIA GRAVIS (see MYASTHENIA GRAVIS, AUTOIMMUNE, EXPERIMENTAL); and MULTIPLE SCLEROSIS (see ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL).

Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.

Presence of air in the mediastinal tissues due to leakage of air from the tracheobronchial tree, usually as a result of trauma.

Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.

A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)

A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.

Polymyositis is defined as a rare inflammatory disorder that causes muscle weakness and inflammation (swelling) of the muscles. It primarily affects the skeletal muscles, which are the muscles responsible for voluntary movements such as walking, talking, and swallowing. The onset of polymyositis can occur at any age but is most commonly seen in adults between 31 to 60 years old, with women being slightly more affected than men.

The exact cause of polymyositis remains unknown; however, it is believed to be an autoimmune disorder, where the body's immune system mistakenly attacks its own muscle tissue. Certain factors such as genetics, viral infections, and exposure to certain drugs may contribute to the development of this condition.

Polymyositis can cause various symptoms, including:
- Progressive muscle weakness and wasting, particularly affecting the proximal muscles (those closest to the trunk of the body) such as the hips, thighs, shoulders, and upper arms.
- Difficulty climbing stairs, lifting objects, or rising from a seated position.
- Fatigue and stiffness, especially after periods of inactivity.
- Joint pain and swelling.
- Difficulty swallowing or speaking.
- Shortness of breath due to weakened respiratory muscles.

Diagnosis of polymyositis typically involves a combination of medical history, physical examination, laboratory tests, electromyography (EMG), and muscle biopsy. Treatment usually includes medications such as corticosteroids and immunosuppressants to reduce inflammation and control the immune response. Physical therapy may also be recommended to help maintain muscle strength and flexibility.

If left untreated, polymyositis can lead to significant disability and complications, including respiratory failure, malnutrition, and cardiovascular disease. Early diagnosis and treatment are crucial for improving outcomes and preventing long-term complications.

Dermatomyositis is a medical condition characterized by inflammation and weakness in the muscles and skin. It is a type of inflammatory myopathy, which means that it causes muscle inflammation and damage. Dermatomyositis is often associated with a distinctive rash that affects the skin around the eyes, nose, mouth, fingers, and toes.

The symptoms of dermatomyositis can include:

* Progressive muscle weakness, particularly in the hips, thighs, shoulders, and neck
* Fatigue
* Difficulty swallowing or speaking
* Skin rash, which may be pink or purple and is often accompanied by itching
* Muscle pain and tenderness
* Joint pain and swelling
* Raynaud's phenomenon, a condition that affects blood flow to the fingers and toes

The exact cause of dermatomyositis is not known, but it is believed to be related to an autoimmune response in which the body's immune system mistakenly attacks healthy tissue. Treatment for dermatomyositis typically involves medications to reduce inflammation and suppress the immune system, as well as physical therapy to help maintain muscle strength and function.

Myositis is a medical term that refers to inflammation of the muscle tissue. This condition can cause various symptoms, including muscle weakness, pain, swelling, and stiffness. There are several types of myositis, such as polymyositis, dermatomyositis, and inclusion body myositis, which have different causes and characteristics.

Polymyositis is a type of myositis that affects multiple muscle groups, particularly those close to the trunk of the body. Dermatomyositis is characterized by muscle inflammation as well as a skin rash. Inclusion body myositis is a less common form of myositis that typically affects older adults and can cause both muscle weakness and wasting.

The causes of myositis vary depending on the type, but they can include autoimmune disorders, infections, medications, and other medical conditions. Treatment for myositis may involve medication to reduce inflammation, physical therapy to maintain muscle strength and flexibility, and lifestyle changes to manage symptoms and prevent complications.

Histidine-tRNA ligase is an enzyme involved in the process of protein synthesis, specifically during the step of translation. Its primary function is to catalyze the attachment of the amino acid histidine to its corresponding transfer RNA (tRNA) molecule. This enzyme does this by forming a ester bond between the carboxyl group of histidine and the 3'-hydroxyl group of the tRNA, creating a charged histidine-tRNA complex.

The histidine-tRNA ligase enzyme plays a crucial role in maintaining the accuracy of protein synthesis, as it ensures that only the correct amino acid is attached to its specific tRNA. This helps to prevent errors in the genetic code and contributes to the proper folding and functioning of proteins.

The systematic name for this enzyme is "histidine:tRNA(His) ligase (AMP-forming)" and it belongs to the family of ligases, specifically the aminoacyl-tRNA ligases. The gene that encodes this enzyme in humans is known as HARS1 (Histidyl-tRNA Synthetase 1). Defects or mutations in this gene can lead to various genetic disorders, such as histidinemia and Charcot-Marie-Tooth disease.

Interstitial lung diseases (ILDs) are a group of disorders characterized by inflammation and scarring (fibrosis) in the interstitium, the tissue and space around the air sacs (alveoli) of the lungs. The interstitium is where the blood vessels that deliver oxygen to the lungs are located. ILDs can be caused by a variety of factors, including environmental exposures, medications, connective tissue diseases, and autoimmune disorders.

The scarring and inflammation in ILDs can make it difficult for the lungs to expand and contract normally, leading to symptoms such as shortness of breath, cough, and fatigue. The scarring can also make it harder for oxygen to move from the air sacs into the bloodstream.

There are many different types of ILDs, including:

* Idiopathic pulmonary fibrosis (IPF): a type of ILD that is caused by unknown factors and tends to progress rapidly
* Hypersensitivity pneumonitis: an ILD that is caused by an allergic reaction to inhaled substances, such as mold or bird droppings
* Connective tissue diseases: ILDs can be a complication of conditions such as rheumatoid arthritis and scleroderma
* Sarcoidosis: an inflammatory disorder that can affect multiple organs, including the lungs
* Asbestosis: an ILD caused by exposure to asbestos fibers

Treatment for ILDs depends on the specific type of disease and its underlying cause. Some treatments may include corticosteroids, immunosuppressive medications, and oxygen therapy. In some cases, a lung transplant may be necessary.

Inclusion body myositis (IBM) is a rare inflammatory muscle disease characterized by progressive weakness and wasting (atrophy) of skeletal muscles. The term "inclusion body" refers to the presence of abnormal protein accumulations within muscle fibers, which are observed under a microscope during muscle biopsy. These inclusions are primarily composed of aggregated forms of amyloid-β and tau proteins, similar to those found in neurodegenerative disorders like Alzheimer's disease.

IBM typically affects individuals over 50 years old, and it is more common in men than women. The disease usually starts with weakness in the wrist and finger flexors, making it difficult to perform tasks such as gripping, buttoning shirts, or lifting objects. Over time, the weakness spreads to other muscle groups, including the thigh muscles (quadriceps), resulting in difficulty climbing stairs or rising from a seated position.

The exact cause of inclusion body myositis remains unclear; however, both immune-mediated and degenerative mechanisms are believed to contribute to its pathogenesis. Currently, there is no cure for IBM, and treatment options are primarily aimed at managing symptoms and improving quality of life. Immunosuppressive medications may be used to target the inflammatory component of the disease; however, their efficacy varies among patients. Physical therapy and exercise programs can help maintain muscle strength and function as much as possible.

Prednisolone is a synthetic glucocorticoid drug, which is a class of steroid hormones. It is commonly used in the treatment of various inflammatory and autoimmune conditions due to its potent anti-inflammatory and immunosuppressive effects. Prednisolone works by binding to specific receptors in cells, leading to changes in gene expression that reduce the production of substances involved in inflammation, such as cytokines and prostaglandins.

Prednisolone is available in various forms, including tablets, syrups, and injectable solutions. It can be used to treat a wide range of medical conditions, including asthma, rheumatoid arthritis, inflammatory bowel disease, allergies, skin conditions, and certain types of cancer.

Like other steroid medications, prednisolone can have significant side effects if used in high doses or for long periods of time. These may include weight gain, mood changes, increased risk of infections, osteoporosis, diabetes, and adrenal suppression. As a result, the use of prednisolone should be closely monitored by a healthcare professional to ensure that its benefits outweigh its risks.

Muscular diseases, also known as myopathies, refer to a group of conditions that affect the functionality and health of muscle tissue. These diseases can be inherited or acquired and may result from inflammation, infection, injury, or degenerative processes. They can cause symptoms such as weakness, stiffness, cramping, spasms, wasting, and loss of muscle function.

Examples of muscular diseases include:

1. Duchenne Muscular Dystrophy (DMD): A genetic disorder that results in progressive muscle weakness and degeneration due to a lack of dystrophin protein.
2. Myasthenia Gravis: An autoimmune disease that causes muscle weakness and fatigue, typically affecting the eyes and face, throat, and limbs.
3. Inclusion Body Myositis (IBM): A progressive muscle disorder characterized by muscle inflammation and wasting, typically affecting older adults.
4. Polymyositis: An inflammatory myopathy that causes muscle weakness and inflammation throughout the body.
5. Metabolic Myopathies: A group of inherited disorders that affect muscle metabolism, leading to exercise intolerance, muscle weakness, and other symptoms.
6. Muscular Dystonias: Involuntary muscle contractions and spasms that can cause abnormal postures or movements.

It is important to note that muscular diseases can have a significant impact on an individual's quality of life, mobility, and overall health. Proper diagnosis and treatment are crucial for managing symptoms and improving outcomes.

Autoantibodies are defined as antibodies that are produced by the immune system and target the body's own cells, tissues, or organs. These antibodies mistakenly identify certain proteins or molecules in the body as foreign invaders and attack them, leading to an autoimmune response. Autoantibodies can be found in various autoimmune diseases such as rheumatoid arthritis, lupus, and thyroiditis. The presence of autoantibodies can also be used as a diagnostic marker for certain conditions.

Paraneoplastic syndromes refer to a group of rare disorders that are caused by an abnormal immune system response to a cancerous (malignant) tumor. These syndromes are characterized by symptoms or signs that do not result directly from the growth of the tumor itself, but rather from substances produced by the tumor or the body's immune system in response to the tumor.

Paraneoplastic syndromes can affect various organs and systems in the body, including the nervous system, endocrine system, skin, and joints. Examples of paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome (LEMS), which affects nerve function and causes muscle weakness; cerebellar degeneration, which can cause difficulty with coordination and balance; and dermatomyositis, which is an inflammatory condition that affects the skin and muscles.

Paraneoplastic syndromes can occur in association with a variety of different types of cancer, including lung cancer, breast cancer, ovarian cancer, and lymphoma. Treatment typically involves addressing the underlying cancer, as well as managing the symptoms of the paraneoplastic syndrome.

Creatine kinase (CK) is a muscle enzyme that is normally present in small amounts in the blood. It is primarily found in tissues that require a lot of energy, such as the heart, brain, and skeletal muscles. When these tissues are damaged or injured, CK is released into the bloodstream, causing the levels to rise.

Creatine kinase exists in several forms, known as isoenzymes, which can be measured in the blood to help identify the location of tissue damage. The three main isoenzymes are:

1. CK-MM: Found primarily in skeletal muscle
2. CK-MB: Found primarily in heart muscle
3. CK-BB: Found primarily in the brain

Elevated levels of creatine kinase, particularly CK-MB, can indicate damage to the heart muscle, such as occurs with a heart attack. Similarly, elevated levels of CK-BB may suggest brain injury or disease. Overall, measuring creatine kinase levels is a useful diagnostic tool for assessing tissue damage and determining the severity of injuries or illnesses.

A muscle is a soft tissue in our body that contracts to produce force and motion. It is composed mainly of specialized cells called muscle fibers, which are bound together by connective tissue. There are three types of muscles: skeletal (voluntary), smooth (involuntary), and cardiac. Skeletal muscles attach to bones and help in movement, while smooth muscles are found within the walls of organs and blood vessels, helping with functions like digestion and circulation. Cardiac muscle is the specific type that makes up the heart, allowing it to pump blood throughout the body.

Connective tissue diseases (CTDs) are a group of disorders that involve the abnormal production and accumulation of abnormal connective tissues in various parts of the body. Connective tissues are the structural materials that support and bind other tissues and organs together. They include tendons, ligaments, cartilage, fat, and the material that fills the spaces between cells, called the extracellular matrix.

Connective tissue diseases can affect many different systems in the body, including the skin, joints, muscles, lungs, kidneys, gastrointestinal tract, and blood vessels. Some CTDs are autoimmune disorders, meaning that the immune system mistakenly attacks healthy connective tissues. Others may be caused by genetic mutations or environmental factors.

Some examples of connective tissue diseases include:

* Systemic lupus erythematosus (SLE)
* Rheumatoid arthritis (RA)
* Scleroderma
* Dermatomyositis/Polymyositis
* Mixed Connective Tissue Disease (MCTD)
* Sjogren's syndrome
* Ehlers-Danlos syndrome
* Marfan syndrome
* Osteogenesis imperfecta

The specific symptoms and treatment of connective tissue diseases vary depending on the type and severity of the condition. Treatment may include medications to reduce inflammation, suppress the immune system, or manage pain. In some cases, surgery may be necessary to repair or replace damaged tissues or organs.

Skeletal muscle, also known as striated or voluntary muscle, is a type of muscle that is attached to bones by tendons or aponeuroses and functions to produce movements and support the posture of the body. It is composed of long, multinucleated fibers that are arranged in parallel bundles and are characterized by alternating light and dark bands, giving them a striped appearance under a microscope. Skeletal muscle is under voluntary control, meaning that it is consciously activated through signals from the nervous system. It is responsible for activities such as walking, running, jumping, and lifting objects.

Systemic Scleroderma, also known as Systemic Sclerosis (SSc), is a rare, chronic autoimmune disease that involves the abnormal growth and accumulation of collagen in various connective tissues, blood vessels, and organs throughout the body. This excessive collagen production leads to fibrosis or scarring, which can cause thickening, hardening, and tightening of the skin and damage to internal organs such as the heart, lungs, kidneys, and gastrointestinal tract.

Systemic Scleroderma is characterized by two main features: small blood vessel abnormalities (Raynaud's phenomenon) and fibrosis. The disease can be further classified into two subsets based on the extent of skin involvement: limited cutaneous systemic sclerosis (lcSSc) and diffuse cutaneous systemic sclerosis (dcSSc).

Limited cutaneous systemic sclerosis affects the skin distally, typically involving fingers, hands, forearms, feet, lower legs, and face. It is often associated with Raynaud's phenomenon, calcinosis, telangiectasias, and pulmonary arterial hypertension.

Diffuse cutaneous systemic sclerosis involves more extensive skin thickening and fibrosis that spreads proximally to affect the trunk, upper arms, thighs, and face. It is commonly associated with internal organ involvement, such as interstitial lung disease, heart disease, and kidney problems.

The exact cause of Systemic Scleroderma remains unknown; however, it is believed that genetic, environmental, and immunological factors contribute to its development. There is currently no cure for Systemic Scleroderma, but various treatments can help manage symptoms, slow disease progression, and improve quality of life.

Myoglobinuria is a medical condition characterized by the presence of myoglobin in the urine. Myoglobin is a protein found in muscle cells that is released into the bloodstream when muscle tissue is damaged or broken down, such as during intense exercise, trauma, or muscle diseases like muscular dystrophy and rhabdomyolysis.

When myoglobin is present in high concentrations in the blood, it can damage the kidneys by causing direct tubular injury, cast formation, and obstruction, which can lead to acute kidney injury (AKI) or even renal failure if left untreated. Symptoms of myoglobinuria may include dark-colored urine, muscle pain, weakness, and swelling, as well as symptoms related to AKI such as nausea, vomiting, and decreased urine output.

Diagnosis of myoglobinuria is typically made by detecting myoglobin in the urine using a dipstick test or more specific tests like immunoassays or mass spectrometry. Treatment may involve aggressive fluid resuscitation, alkalization of the urine to prevent myoglobin precipitation, and management of any underlying conditions causing muscle damage.

A nervous system autoimmune disease, experimental, refers to a type of disorder in which the immune system mistakenly attacks healthy nerves or tissues in the nervous system. This category includes conditions that are currently being researched and have not yet been fully proven or accepted by the medical community as definitive diseases.

In an autoimmune disease, the body's immune system produces antibodies and activates immune cells (such as T-cells) to attack and destroy foreign substances, such as bacteria and viruses. However, in an experimental nervous system autoimmune disease, the immune system mistakenly identifies normal nerves or nerve tissues as harmful and attacks them. This can lead to damage or destruction of the nerves, resulting in various neurological symptoms.

Examples of experimental nervous system autoimmune diseases may include conditions such as MOG antibody-associated disease (MOGAD) or anti-NMDA receptor encephalitis, which are still being studied and have not yet been fully recognized by the medical community. It is important to note that while these conditions are considered experimental, they can still cause significant harm and should be treated with appropriate medical interventions.

Autoimmune diseases are a group of disorders in which the immune system, which normally protects the body from foreign invaders like bacteria and viruses, mistakenly attacks the body's own cells and tissues. This results in inflammation and damage to various organs and tissues in the body.

In autoimmune diseases, the body produces autoantibodies that target its own proteins or cell receptors, leading to their destruction or malfunction. The exact cause of autoimmune diseases is not fully understood, but it is believed that a combination of genetic and environmental factors contribute to their development.

There are over 80 different types of autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, type 1 diabetes, Hashimoto's thyroiditis, Graves' disease, psoriasis, and inflammatory bowel disease. Symptoms can vary widely depending on the specific autoimmune disease and the organs or tissues affected. Treatment typically involves managing symptoms and suppressing the immune system to prevent further damage.

Mediastinal emphysema is a medical condition characterized by the presence of air or gas within the mediastinum, which is the central compartment of the thorax that contains the heart, esophagus, trachea, bronchi, thymus gland, and other associated structures.

In mediastinal emphysema, the air accumulates in the mediastinal tissues and spaces, leading to their abnormal distention or swelling. This condition can result from various causes, including:

* Pulmonary trauma or barotrauma (e.g., mechanical ventilation, scuba diving)
* Infections that cause gas-forming organisms (e.g., pneumomediastinum)
* Air leakage from the lungs or airways (e.g., bronchial rupture, esophageal perforation)
* Certain medical procedures (e.g., mediastinoscopy, tracheostomy)

Mediastinal emphysema can cause symptoms such as chest pain, cough, difficulty breathing, and swallowing problems. In severe cases, it may lead to life-threatening complications, including tension pneumothorax or mediastinitis. Treatment depends on the underlying cause and severity of the condition.

Antinuclear antibodies (ANA) are a type of autoantibody that target structures found in the nucleus of a cell. These antibodies are produced by the immune system and attack the body's own cells and tissues, leading to inflammation and damage. The presence of ANA is often used as a marker for certain autoimmune diseases, such as systemic lupus erythematosus (SLE), Sjogren's syndrome, rheumatoid arthritis, scleroderma, and polymyositis.

ANA can be detected through a blood test called the antinuclear antibody test. A positive result indicates the presence of ANA in the blood, but it does not necessarily mean that a person has an autoimmune disease. Further testing is usually needed to confirm a diagnosis and determine the specific type of autoantibodies present.

It's important to note that ANA can also be found in healthy individuals, particularly as they age. Therefore, the test results should be interpreted in conjunction with other clinical findings and symptoms.

Muscle weakness is a condition in which muscles cannot develop the expected level of physical force or power. This results in reduced muscle function and can be caused by various factors, including nerve damage, muscle diseases, or hormonal imbalances. Muscle weakness may manifest as difficulty lifting objects, maintaining posture, or performing daily activities. It is essential to consult a healthcare professional for proper diagnosis and treatment of muscle weakness.

Muscular dystrophies are a group of genetic disorders that primarily affect skeletal muscles, causing progressive weakness and degeneration. They are characterized by the lack or deficiency of a protein called dystrophin, which is essential for maintaining the integrity of muscle fibers. The most common form is Duchenne muscular dystrophy (DMD), but there are many other types with varying symptoms and severity. Over time, muscle wasting and weakness can lead to disability and shortened lifespan, depending on the type and progression of the disease. Treatment typically focuses on managing symptoms, maintaining mobility, and supporting quality of life.

Immunosuppressive agents are medications that decrease the activity of the immune system. They are often used to prevent the rejection of transplanted organs and to treat autoimmune diseases, where the immune system mistakenly attacks the body's own tissues. These drugs work by interfering with the immune system's normal responses, which helps to reduce inflammation and damage to tissues. However, because they suppress the immune system, people who take immunosuppressive agents are at increased risk for infections and other complications. Examples of immunosuppressive agents include corticosteroids, azathioprine, cyclophosphamide, mycophenolate mofetil, tacrolimus, and sirolimus.

Mixed Connective Tissue Disease (MCTD) is a rare overlapping condition of the connective tissues, characterized by the presence of specific autoantibodies against a protein called "U1-snRNP" or "U1-small nuclear ribonucleoprotein." This disorder has features of various connective tissue diseases such as systemic lupus erythematosus (SLE), scleroderma, polymyositis, and rheumatoid arthritis. Symptoms may include swollen hands, joint pain and swelling, muscle weakness, skin thickening, lung involvement, and Raynaud's phenomenon. The exact cause of MCTD is unknown, but it is believed to involve both genetic and environmental factors leading to an autoimmune response. Early diagnosis and treatment are essential for better disease management and preventing severe complications.

Dysphagia (difficulty swallowing) or other problems with esophageal motility occur in as many as 1/3 of patients. Low grade ... The hallmark of polymyositis is weakness and/or loss of muscle mass in the proximal musculature, as well as flexion of the neck ... Polymyositis tends to become evident in adulthood, presenting with bilateral proximal muscle weakness often noted in the upper ... Polymyositis (PM) is a type of chronic inflammation of the muscles (inflammatory myopathy) related to dermatomyositis and ...

https://en.wikipedia.org/wiki/Polymyositis

Safety of a home exercise programme in patients with polymyositis and dermatomyositis: A pilot study. Rheumatology. 38, 608-611 ... Improvement of physical fitness and muscle strength in polymyositis/dermatomyositis patients by a training programme. British ... In 2001, 22 patients were placed on a three-week physical therapy and exercise program, and found that creatine kinase levels ... exercise increases strength and does not produce sustained creatinine phosphokinase increases in a patient with polymyositis. ...

https://en.wikipedia.org/wiki/Exercise_therapy_for_idiopathic_inflammatory_myopathies

An exercise regimen preferentially minimizes a patient's risk of injury and corresponds to the patient's goals. When sIBM was ... IBM is often confused with (misdiagnosed as) polymyositis. Polymyositis that does not respond to treatment is likely IBM. ... but exhibits a skin rash not seen in polymyositis or sIBM. It may have different root causes unrelated to either polymyositis ... Patients with sIBM usually eventually need to resort to a cane or a walker and in most cases, a wheelchair eventually becomes a ...

https://en.wikipedia.org/wiki/Inclusion_body_myositis

"Polymyositis and Dermatomyositis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Health Handbook". Ghirardello A ... Albert ML, Austin LM, Darnell RB (2000). "Detection and treatment of activated T cells in the cerebrospinal fluid of patients ... 2018). "GDP-l-fucose synthase is a CD4+ T cell-specific autoantigen in DRB3*02:02 patients with multiple sclerosis" (PDF). ... I. A clinical analysis of 55 anti-Yo antibody-positive patients". Neurology. 42 (10): 1931-7. doi:10.1212/wnl.42.10.1931. PMID ...

https://en.wikipedia.org/wiki/List_of_autoimmune_diseases

156 The study of masticatory force in patients with polymyositis and dermatomyositis shows that hyposalivation and mucosal ... "Evaluation of oral manifestations and masticatory force in patients with polymyositis and dermatomyositis". Journal of Oral ...

https://en.wikipedia.org/wiki/Masticatory_force

... polymyositis, or dermatomyositis alone. As the autobodies are found mainly in patients that have characteristics of several ... "PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome". Arthritis & Rheumatism. 50 ( ... an autoimmune disease in which patients have symptoms from both scleroderma and either polymyositis or dermatomyositis. ... "C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome". Arthritis & Rheumatism. 56 ...

https://en.wikipedia.org/wiki/Exosome_complex

"C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome". Arthritis and Rheumatism. ...

https://en.wikipedia.org/wiki/C1D

High troponin T levels have also been reported in patients with inflammatory muscle diseases such as polymyositis or ... April 2001). "Cardiac troponin and beta-type myosin heavy chain concentrations in patients with polymyositis or dermatomyositis ... According to the latest data cTnI is released in the blood stream of the patient in the form of binary complex with TnC or ... Of course, patients with COPD exacerbations might also have concurrent myocardial infarction or pulmonary embolism, so care has ...

https://en.wikipedia.org/wiki/Troponin

2004). "PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome". Arthritis Rheum. 50 ... the protein product of which is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases ... "Cloning and characterization of the cDNA coding for a polymyositis-scleroderma overlap syndrome-related nucleolar 100-kD ...

https://en.wikipedia.org/wiki/Exosome_component_10

2004). "PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome". Arthritis Rheum. 50 ... the protein product of which is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases ... "Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete ...

https://en.wikipedia.org/wiki/Exosome_component_9

... dermatomyositis and polymyositis". Int. J. Cancer. 116 (6): 925-33. doi:10.1002/ijc.21118. PMID 15856462. S2CID 880049. Rual JF ... "Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, ...

https://en.wikipedia.org/wiki/PMS1

CT scans are also used to discover issues in the patient. As for autopsies, the principal work of the neuropathologist is to ... Muscle biopsies are taken to aid in the diagnosis of muscle diseases (such as polymyositis, mitochondrial myopathy, etc.). ... They often do not work with patients but only with medical professionals or other officials behind the scene. They research ... Peripheral nerve is assessed to help work up patients with suspected peripheral neuropathies secondary to such conditions as ...

https://en.wikipedia.org/wiki/Neuropathology

Treatment of these patients is therefore strongly dependent on the exact symptoms with which a patient reports to a physician ... Polymyositis: a rare inflammatory disease that causes muscle weakness affecting both sides of your body. Dermatomyositis: an ... Although it is a rare disease, it is one of the more common overlap syndromes seen in scleroderma patients, together with MCTD ... Autoantibodies often found in these patients are the anti-PM/Scl (anti-exosome) antibodies. The symptoms that are seen most ...

https://en.wikipedia.org/wiki/Scleromyositis

... levels were significantly higher in patients with OSA compared to obese control subjects. Patients with OSA have higher plasma ... Scleroderma, polymyositis, and dermatomyositis elicit little or no CRP response.[citation needed] CRP levels also tend not to ... CRP was so named because it was first identified as a substance in the serum of patients with acute inflammation that reacted ... It has been hypothesized that patients with high CRP levels might benefit from use of statins. This is based on the JUPITER ...

https://en.wikipedia.org/wiki/C-reactive_protein

In other words, patients who used BFR training for exercises were compared to patients who did not, and it was found that those ... BFRT has shown to be a promising adjuvant therapy in dermatomyositis, polymyositis, and inclusion body myositis. BFRT has been ... Studies have shown that BFR training also allows patients with knee (OA) to endure more intense exercises with less pain. ... BFRT has been shown to improve physical function, and improve pain and stiffness in patients with knee osteoarthritis (OA). ...

https://en.wikipedia.org/wiki/Blood_flow_restriction_training

The most common antibody is "Anti-Jo-1" named after John P, a patient with polymyositis and interstitial lung disease detected ... For patients with pulmonary involvement, the most serious complication of this syndrome is pulmonary fibrosis and subsequent ... This anti-histidyl tRNA Synthetase antibody is commonly seen in patients with pulmonary manifestations of the syndrome. The ... Nishikai M, Reichlin M (1980). "Heterogeneity of precipitating antibodies in polymyositis and dermatomyositis". Arthritis Rheum ...

https://en.wikipedia.org/wiki/Antisynthetase_syndrome

Patients with dermatomyositis and polymyositis have increased IFN serum levels which in some studies correlate with disease ... MS patients have lower levels of circulating type I interferon compared to patients with other autoimmune diseases. However, a ... Furthermore, patients with non-autoimmune diseases treated with IFN-α can develop a "lupus-like" syndrome, including ... Also, studies have suggested a genetic or heritable component to the high type I IFN observed in myositis patients, similar to ...

https://en.wikipedia.org/wiki/Interferon_alpha-1

Drop foot TC: Terminal contact that is observed in patients that have drop foot is quite different. Since patients tend to have ... Yoga foot drop Toe walking Polymyositis inclusion body myositis Chisholm, Amanda E.; Perry, Stephen D.; McIlroy, William E. ( ... Patients with painful disorders of sensation (dysesthesia) of the soles of the feet may have a similar gait but do not have ... They have benefited patients by improving gait speed, muscle strength and other functions. Treatment for some can be as easy as ...

https://en.wikipedia.org/wiki/Foot_drop

... and polymyositis, so often, in the initial phases, the diagnosis most appropriate for patients is "undifferentiated connective ... Even with a low anti-RNP antibody titer, a patient can show symptoms of MTD. The reverse is also possible: a patient with a ... These antibodies are in most MCTD patients but are seen in only 30-35% of SLE and 2-14% of scleroderma patients, therefore they ... Morbidity is quite high in patients with MCTD. In addition to fatigue and recurrent musculoskeletal complaints, patients can ...

https://en.wikipedia.org/wiki/Mixed_connective_tissue_disease

A population cohort study in Taiwan suggested that patients with PR had an increased risk of developing rheumatoid arthritis, ... systemic lupus erythematosus, Sjogren's syndrome, systemic sclerosis, and polymyositis. Palindromic rheumatism is a disease of ... are present in a high proportion of patients, as is the case in rheumatoid arthritis. Unlike RA and some other forms of ... comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients". The ...

https://en.wikipedia.org/wiki/Palindromic_rheumatism

... recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome". Proc. Natl. Acad. Sci. U.S.A. 87 (5 ... Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies ... A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. A deficiency ...

https://en.wikipedia.org/wiki/Ku80

Prioritising patients for elective (non-urgent) surgery, rheumatology and nephrology, geriatrics and gastroenterology ... dermatomyositis and polymyositis, pediatric post-thrombotic syndrome, systemic lupus erythematosus, Sjögren's syndrome and ... Taylor, William J.; Brown, Melanie; Aati, Opetaia; Weatherall, Mark; Dalbeth, Nicola (2013). "Do Patient Preferences for Core ... glucocorticoid toxicity Measuring patient responses in clinical trials for chronic gout Testing physical function for patients ...

https://en.wikipedia.org/wiki/1000minds

There are some concerns with the use of anti-TNF agents in patients with systemic autoimmune diseases due to the risk of ... Systemic sclerosis Polymyositis Dermatomyositis Rheumatoid arthritis (RA) Sjögren's syndrome Eosinophilic granulomatosis with ... Diagnosis depends on which diseases the patient shows symptoms and has positive antibodies for in their lab serology. In ...

https://en.wikipedia.org/wiki/Overlap_syndrome

"Simvastatin 80 mg should not be started in new patients, including patients already taking lower doses of the drug," the agency ... M33.2) Polymyositis produces muscle weakness. It can often be treated by drugs like corticosteroids or immunosuppressants. ... Patients with systemic myopathies often present acutely or sub acutely. On the other hand, familial myopathies or dystrophies ... The FDA drug safety communication stated that physicians should limit using the 80-mg dose unless the patient has already been ...

https://en.wikipedia.org/wiki/Myopathy

Treatment strategies will differ on a patient to patient basis and should be structured to meet the specific needs of each ... Esophageal varices Benign strictures Achalasia Esophageal diverticula Scleroderma Diffuse esophageal spasm Polymyositis Webs ... and patient complaint of swallowing difficulty. When asked where the food is getting stuck, patients will often point to the ... Some patients have limited awareness of their dysphagia, so lack of the symptom does not exclude an underlying disease. When ...

https://en.wikipedia.org/wiki/Dysphagia

Certain Human leukocyte antigen class II genes appear more frequently in patients with Kikuchi disease, suggesting that there ... Other autoimmune conditions and manifestations such as antiphospholipid syndrome, polymyositis, systemic juvenile idiopathic ... in Japanese patients with histiocytic necrotizing lymphadentis (Kikuchi's disease) 8". Tissue Antigens. 54 (3): 246-253. doi: ... a self-limiting illness which has symptoms which may overlap with Hodgkin's lymphoma leading to misdiagnosis in some patients. ...

https://en.wikipedia.org/wiki/Kikuchi_disease

It has been found that patients with ATA that recognize the ET4 domain of topoisomerase were frequently HLA-DR2, and in another ... de Rooij DJ, Van de Putte LB, Habets WJ, Van Venrooij WJ (1989). "Marker antibodies in scleroderma and polymyositis: clinical ... Samuels DS, Tojo T, Homma M, Shimizu N (1986). "Inhibition of topoisomerase I by antibodies in sera from scleroderma patients ... Guldner HH, Szostecki C, Vosberg HP, Lakomek HJ, Penner E, Bautz FA (1986). "Scl 70 autoantibodies from scleroderma patients ...

https://en.wikipedia.org/wiki/Anti-topoisomerase_antibodies

Polymyositis-dermatomyositis: a clinical review. Postgrad Med J. 1989;65:437-43. Hulstaert F, I. Hannet, V. Deneys, V. ... Correlation of CD8 lymphocyte activation with cellular viremia and plasma HIV RNA levels in asymptomatic patients infected by ... New injection recommendations for patients with diabetes. Diabetes Metab. 2010;36 Suppl 2:S3-18. Frid AH, Hirsch LJ, Menchior ... A pan-European epidemiologic study of insulin injection technique in patients with diabetes. Pract Diab Int 2002;19:71-76. ...

https://en.wikipedia.org/wiki/Ken_Strauss

... is a human monoclonal antibody designed for the treatment of SLE, dermatomyositis, and polymyositis. It targets ... "Press release: New Hope for Lupus Patients". MedImmune. 11 August 2015. Archived from the original on 31 July 2017. " ...

https://en.wikipedia.org/wiki/Sifalimumab

The median age of these patients at the time of thymoma diagnosis was 57 years. Patients who have undergone thymectomy for ... polymyositis, rheumatoid arthritis, sarcoidosis, scleroderma, sensorimotor radiculopathy, stiff person syndrome, systemic lupus ... One-third of patients have their tumors discovered because they have an associated autoimmune disorder. As mentioned earlier, ... A study found that slightly over 40% of observed patients with stage III and IV tumors survived for at least 10 years after ...

https://en.wikipedia.org/wiki/Thymoma

... in three patients with unspecified myositis (clinical polymyositis) and in two patients with possible myositis (colon (n = 2), ... polycyclic in 21 patients (20%) and chronic continuous in 62 patients (60%). Fifteen patients with a polycyclic course had one ... Strength in polymyositis and dermatomyositis: best outcome in patients treated early. J Rheumatol1994;21:643-8. ... Adult onset polymyositis/dermatomyositis: an analysis of clinical and laboratory features and survival in 76 patients with a ...

https://ard.bmj.com/content/65/11/1456?ijkey=17f87c535c32c10ee97db344d1d42d871dd04275&keytype2=tf_ipsecsha

Stability Among Patients With. Advanced Heart Failure and. Reduced Ejection Fraction: A. Randomized Clinical Trial.. Revie. w. ... 33 patients (45.2%) with esophageal impairment developed aspiration pneumonia. Sixty patients (82.2%) exhibited resolution of ... Treatment of Patients With Heart. Failure. Importance: Only 1 class of glucose-lowering agents-. sodium-glucose cotransporter 2 ... patients with chronic heart failure:. findings in the ALiskiren Observation. of heart Failure Treatment study.. CONCLUSIONS: ...

https://read.qxmd.com/read/20722047/intravenous-immunoglobulins-for-steroid-refractory-esophageal-involvement-related-to-polymyositis-and-dermatomyositis-a-series-of-73-patients?redirected=slug

Clinically similar to polymyositis, dermatomyositis is an idiopathic, inflammatory myopathy associated with ... ... Polymyositis is an idiopathic inflammatory myopathy that causes symmetrical, proximal muscle weakness; elevated skeletal muscle ... Patient Education. Patients with polymyositis should be educated early about the disease, its complications, and treatment ... For patient education information, see Polymyositis. In addition, patients may visit The Myositis Association Web site. ...

https://emedicine.medscape.com/article/335925-overview

... presents with predominant or isolated proximal upper limb and neck weakness. It has marked female ... patients on needle electromyography studies, and all patients had evidence of inflammatory myopathy (polymyositis) on muscle ... was used in 2 patients and plasmapharesis in 1 patient. Conclusions: Cervicobrachial polymyositis presents with predominant or ... Methods: Patients with polymyositis, presenting with predominant or isolated weakness of upper limbs and the neck, were ...

https://pubmed.ncbi.nlm.nih.gov/25415516/

Fortunately, most patients with this form of muscle disease recover completely.. Dermatomyositis and Polymyositis ... As with patients with chronic steroid-induced myopathy, patients with these diseases have difficulty rising from chairs and ... Patients with dermatomyositis may also have a rash that appears on the eyelids and over the bony prominences of the hands. This ... In addition, patients complain of fatigue, loss of appetite and fever. Polymyalgia rheumatica is often treated with a low-dose ...

https://www.livestrong.com/article/536475-sore-muscles-prednisone/

Herein, we report on two human immunodeficiency virus (HIV)-infected patients with leishmaniasis who presented with overlapping ... A Masquerade of Infectious Myositis as Polymyositis Authors: Victoria Marie Ferreira Mank ... A suspected new species of Leishmania, the causative agent of visceral leishmaniasis in a Thai patient. Int J Parasitol 38: 617 ... A suspected new species of Leishmania, the causative agent of visceral leishmaniasis in a Thai patient. Int J Parasitol 38: 617 ...

https://www.ajtmh.org/abstract/journals/tpmd/87/1/article-p76.xml?rskey=gahmci&result=3

Polymyositis/dermatomyositis. *Vasculitis (e.g giant cell arteritis). *Necrotising arteritis. *Sarcoidosis *Polyarteritis ...

https://www.cdc.gov/h1n1flu/arthritis.htm

Patient education: Dermatomyositis (The Basics). Patient education: Polymyositis (The Basics). Patient education: Antinuclear ... Patient level information - UpToDate offers two types of patient education materials.. The Basics - The Basics patient ... Since polymyositis and dermatomyositis cannot be cured but can be controlled by medications, it is important for patients with ... Patient education: Polymyositis, dermatomyositis, and other forms of idiopathic inflammatory myopathy (Beyond the Basics). ...

https://www.medilib.ir/uptodate/show/578

Polymyositis is a very rare idiopathic inflammatory myopathy ... Patients often present with skin rash *Polymyositis is a ... M33.21 - polymyositis with respiratory involvement *M33.22 - polymyositis with myopathy *M33.29 - polymyositis with other organ ... Polymyositis. Authors: Ashley M. Holloman, M.D., Carrie A. Mohila, M.D., Ph.D. ... Existence of polymyositis as a distinct entity has been questioned and may not be included in some idiopathic inflammatory ...

https://www.pathologyoutlines.com/topic/musclepolymyositis.html

https://en.wikipedia.org/wiki/Polymyositis

Patients in the control group did not show any consistent changes during the 12-week study. Polymyositis and dermatomyositis ... In the first part of this study, we compared 23 patients with polymyositis or dermatomyositis with 12 age- and gender-matched ... A subgroup of patients were randomized to perform a 12-week endurance training program (exercise group, n = 9) or to a non- ... Patients in the exercise group increased their cycling time, aerobic capacity and CS and β-HAD activities, whereas lactate ...

https://arthritis-research.biomedcentral.com/articles/10.1186/ar4263

High Pre-Treatment Neutrophil-To-Lymphocyte Ratio in Patients With dermatomyositis/polymyositis Predicts an Increased Risk of ... PUBLICATION] High Pre-Treatment Neutrophil-To-Lymphocyte Ratio in Patients With dermatomyositis/polymyositis Predicts an ... publication-high-pre-treatment-neutrophil-to-lymphocyte-ratio-in-patients-with-dermatomyositis-polymyositis-predicts-an- ... Results: In total, 75 patients had a diagnosis of DM/PM (median age: 60 [Q1-Q3: 41.3-70.2] years and median follow-up: 3.5 [Q1- ...

https://ibrain.univ-tours.fr/version-francaise/actualites/publication-high-pre-treatment-neutrophil-to-lymphocyte-ratio-in-patients-with-dermatomyositis-polymyositis-predicts-an-increased-risk-of-cancer

Polymyositis/Dermatomyositis. *Primary Immunodeficiencies/ Immunodeficiency Associated Autoimmunity. *Seronegative ... Providing patients compassionate care and comprehensive treatment of diseases affecting the joints and connective tissues. ... the breadth of knowledge and large number of rheumatologists allows us to provide the comprehensive care for patients by ...

https://www.uab.edu/medicine/rheumatology/patientcare

SLE: ANA is almost always present in patients w/ SLE (95% to 98%);. - medication induced lupus like syndrome (procainamide);. ... polymyositis. - false positive result:. - Graves disease. - Hashimotos thyroiditis. Categories Arthritis Tags Arthritis, ...

https://www.wheelessonline.com/arthritis/antinuclear-antibody-ana/

Polymyositis affects the same muscle groups dermatomyositis does. It also causes the same skin rashes that patients with ... Patients and Visitors Resources Bill Pay Classes & Events Chat with UPMC Medical Records Patient Education Patient Information ... For patients of UPMC-affiliated doctors in Central Pa, select UPMC Central Pa Portal. Patients of UPMC Cole should select the ... UPMC Patient Portals Your health information, right at your fingertips. Select MyUPMC to access your UPMC health information. ...

https://www.upmc.com/services/rheumatology/conditions/myositis

Fatal disseminated Anncaliia algerae myositis mimicking polymyositis in an immunocompromised patient. Neuromuscul Disord. 2021; ... 11 were among immunocompromised patients (Table). Thus, immunodeficiency, as in this patient, appears to be a critical risk ... However, the patients condition continued to deteriorate. On day 51, he decided on comfort care and died 2 days later (Figure ... A. algerae infection in humans primarily manifests as myositis (1-11), and in reports we reviewed, 5 (62.5%) of 8 case-patients ...

https://wwwnc.cdc.gov/eid/article/28/7/21-2315

Myositis/polymyositis rhabdomyolysis (and associated sequelae, including renal failure), arthritis (1.5%), polymyalgia ... In KEYNOTE-051, 161 pediatric patients (62 pediatric patients aged 6 months to younger than 12 years and 99 pediatric patients ... 16 patients receiving axitinib, and 24 patients receiving both. All patients with a recurrence of ALT ≥3 ULN subsequently ... of patients. All patients who were withheld reinitiated KEYTRUDA after symptom improvement. The majority of patients with ...

https://www.merck.com/news/european-commission-approves-mercks-keytruda-pembrolizumab-plus-chemotherapy-for-certain-patients-with-esophageal-cancer-or-her2-negative-gastroesophageal-junction-gej-adenocarcinom/

https://www.merck.com/news/merck-receives-positive-eu-chmp-opinion-for-keytruda-pembrolizumab-as-first-line-treatment-in-adult-patients-with-metastatic-microsatellite-instability-high-msi-h-or-mismatch-repair-deficien/

Myositis/polymyositis, rhabdomyolysis (and associated sequelae, including renal failure), arthritis (1.5%), polymyalgia ... In KEYNOTE-051, 161 pediatric patients (62 pediatric patients aged 6 months to younger than 12 years and 99 pediatric patients ... 16 patients receiving axitinib, and 24 patients receiving both. All patients with a recurrence of ALT ≥3 ULN subsequently ... of patients. All patients who were withheld reinitiated KEYTRUDA after symptom improvement. The majority of patients with ...

https://www.businesswire.com/news/home/20210810005544/en/FDA-Accepts-Application-for-Merck%E2%80%99s-KEYTRUDA%C2%AE-pembrolizumab-as-Single-Agent-for-Certain-Patients-With-MSI-HdMMR-Advanced-Endometrial-Carcinoma/

... polymyositis (PM), ankylosing spondylitis (AS), Sjögren syndrome (SS), and m... ... Interstitial lung disease in patients with polymyositis, dermatomyositis and amyopathic dermatomyositis. Rheumatology (Oxford) ... Incidence of polymyositis-dermatomyositis: a 20-year study of hospital diagnosed cases in Allegheny County, PA 1963-1982. J ... Characterisation of patients with interstitial pneumonia with autoimmune features. Eur Respir J. 2016 Jun. 47 (6):1767-75. [ ...

https://emedicine.medscape.com/article/1343513-medication

However, patients with an atypical disease presentation, particularly those with early-stage disease, can be challenging to ... and polymyositis can normally be distinguished on the basis of clinical features. ... Inclusion body myositis (IBM) and polymyositis can normally be distinguished on the basis of clinical features. However, ... Ubiquitinated inclusions in inclusion-body myositis patients are immunoreactive for cathepsin D but not beta-amyloid. Neurosci ...

https://www.nature.com/articles/s41584-019-0223-9?error=cookies_not_supported&code=693428b2-3d81-4006-9c21-de586895ad6d

Planned duration of participation for each patient is at least 38 days, excluding the screening period. Eligible patients will ... Basic inclusion criteria are: 1) medical diagnosis of polymyositis (PM) or dermatomyositis (DM); 2) symptoms of active disease ... Female patients and caregivers of female patients are eligible to complete this survey. ... tolerability and efficacy of amifampridine phosphate in patients with MuSK-MG. In addition, a sample of AChR-MG patients will ...

https://rarediseases.org/living-with-a-rare-disease/find-clinical-trials/page/3/

In KEYNOTE-051, 173 pediatric patients (65 pediatric patients aged 6 months to younger than 12 years and 108 pediatric patients ... Myositis/polymyositis, rhabdomyolysis (and associated sequelae, including renal failure), arthritis (1.5%), polymyalgia ... 16 patients receiving axitinib, and 24 patients receiving both. All patients with a recurrence of ALT ≥3 ULN subsequently ... Increased Mortality in Patients With Multiple Myeloma In trials in patients with multiple myeloma, the addition of KEYTRUDA to ...

https://www.streetinsider.com/Business+Wire/Merck+and+Eisai+Provide+Update+on+Two+Phase+3+Trials+Evaluating+KEYTRUDA%C2%AE+%28pembrolizumab%29+Plus+LENVIMA%C2%AE+%28lenvatinib%29+in+Patients+With+Certain+Types+of+Metastatic+Non-Small+Cell+Lung+Cancer/22189026.html

Autoimmune disorders (eg, Graves disease, polymyositis, and Guillain-Barré syndrome) may also occur. ... However, elderly patients are more likely to have age-related kidney, liver, or heart problems which may require caution and an ... Monitor patients intensively during the first 18 weeks of therapy with nevirapine to detect potentially life-threatening ... Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare ...

https://www.drugs.com/cons/viramune-xr.html

Patients * Patients, Carers and Community. * Allergy and Clinical Immunology Services * What is a Clinical Immunology/Allergy ... Polymyositis (skin, muscles). *Rheumatoid arthritis (joints, less commonly lungs, skin, eyes). *Scleroderma (skin, intestine, ...

https://www.allergy.org.au/patients/autoimmunity/autoimmune-diseases

Refer your patient. / Rheumatology. / Myositis - Polymyositis, dermatomyositis, CTD associated myositis and undifferentiated ... If your patient lives outside the Metro North Health area and you wish to refer them to one of our services, inclusion of ... If your patient does not meet the minimum referral criteria. Consider other treatment pathways or an alternative diagnosis. ... Metro North Central Patient Intake. Aspley Community Centre. 776 Zillmere Road. ASPLEY QLD 4035. Hotline: 1300 364 938 ...

https://metronorth.health.qld.gov.au/specialist_service/refer-your-patient/rheumatology/myositis

Interstitial lung disease in patients with polymyositis, dermatomyositis and amyopathic dermatomyositis. Rheumatology (Oxford) ... Labelling a patient as having IPAF defines the cohort as unique; these patients do not have a classifiable CTD, yet they may be ... Clinical manifestations in patients with antibody to PL-12 antigen (alanyl-tRNA synthetase). Am J Med 1990; 88: 241-251. ... Thus, to be considered as having IPAF, a patient with a UIP pattern on HRCT would need to have at least one feature from the ...

https://erj.ersjournals.com/content/46/4/976?ijkey=7a1fd7453661eba888ef93728925dbffe65d8a39&keytype2=tf_ipsecsha

This is the first study to demonstrate a positive association between ANKRD55 polymorphism and dermatomyositis/polymyositis ... with interstitial lung disease (DM/PM)-ILD . A decreased frequency of rs7731626-A in DM-ILD and DM/PM-ILD patients suggests ... Positive Association between ANKRD55 Polymorphism 7731626 and Dermatomyositis/Polymyositis with Interstitial Lung Disease in ... Title: Positive Association between ANKRD55 Polymorphism 7731626 and Dermatomyositis/Polymyositis with Interstitial Lung ...

https://www.ncbi.nlm.nih.gov/gene/79722

Aging patients with and without dementia may also be studied.. Patients with Post Polio Syndrome, Polymyositis, Dermatomyositis ... Patients will be seen who are enrolled in NCI and NIDCD protocols for head and neck. tumors.. EXCLUSION CRITERIA. Normal ... research implications for patients with disorders affecting the oral peripheral muscles,. salivary gland flow and the central ... of tumor staging, tumor volume, and tumor recurrence in patients with tumors of the larynx,. oral cavity and hypopharynx. ...

https://www.knowcancer.com/cancer-trials/NCT00001167/

Dermatomyositis and polymyositis are autoimmune diseases that can both cause muscle weakness. (livestrong.com)
Necrotizing myopathy is a more newly defined form of myositis with muscle weakness similar to that of dermatomyositis and polymyositis. (upmc.com)
It shows different features on a muscle biopsy than dermatomyositis and polymyositis do. (upmc.com)
I knew there was dermatomyositis and polymyositis. (medscape.com)
Serum interleukin-17A level is associated with disease activity of adult patients with dermatomyositis and polymyositis. (cdc.gov)

The cumulative risk of incident connective tissue disorder in patients with myositis was significantly increased. (bmj.com)
Idiopathic inflammatory myopathies comprise a heterogeneous group of disorders, including polymyositis, dermatomyositis and sporadic inclusion body myositis (s-IBM). (bmj.com)
Polymyositis (PM) is a type of chronic inflammation of the muscles (inflammatory myopathy) related to dermatomyositis and inclusion body myositis. (wikipedia.org)
Foot drop in one or both feet can be a symptom of advanced polymyositis and inclusion body myositis. (wikipedia.org)
Anncaliia algerae is an uncommon, yet emerging microsporidian parasitic pathogen that can affect immunocompromised patients and cause fatal myositis ( 1 , 2 ). (cdc.gov)
Inclusion body myositis (IBM) and polymyositis can normally be distinguished on the basis of clinical features. (nature.com)
18F]Florbetapir positron emission tomography: identification of muscle amyloid in inclusion body myositis and differentiation from polymyositis. (nature.com)
Ubiquitinated inclusions in inclusion-body myositis patients are immunoreactive for cathepsin D but not beta-amyloid. (nature.com)
New onset and/or active myositis including polymyositis, dermatomyositis. (qld.gov.au)
Patients may visit The Myositis Association Web site for more information. (medscape.com)
Immune-mediated inflammatory myopathies include polymyositis, dermatomyositis, myositis resulting from a rheumatic disease or overlap syndrome, inclusion body myositis (IBM), and immune-mediated necrotizing myopathy. (mhmedical.com)
autoantibodies in adult patients with myositis. (cdc.gov)
Novel susceptibility alleles in HLA region for myositis and myositis specific autoantibodies in Korean patients. (cdc.gov)
The spectrum and clinical significance of myositis-specific autoantibodies in Chinese patients with idiopathic inflammatory myopathies. (cdc.gov)

Muscle weakness, thoracic myopathy, and aspiration pneumonia were independent predictive factors of IVIG-treated esophageal complications in PM/DM patients. (qxmd.com)
[ 2 ] Clinically similar to polymyositis, dermatomyositis is an idiopathic inflammatory myopathy associated with characteristic dermatologic manifestations. (medscape.com)
This is the most common inflammatory myopathy in patients older than age 50 years. (medscape.com)
Active irritative myopathy was found in 93% (13/14) patients on needle electromyography studies, and all patients had evidence of inflammatory myopathy (polymyositis) on muscle biopsy. (nih.gov)
As with patients with chronic steroid-induced myopathy, patients with these diseases have difficulty rising from chairs and climbing stairs. (livestrong.com)
Alternative Treatment For Polymyositis With Herbal Remedies Abstract The disease is also known as myopathy. (planetayurveda.com)
Human leukocyte antigen in Japanese patients with idiopathic inflammatory myopathy. (cdc.gov)

Serum creatine kinase was elevated (median CK, 1275 IU/L). Of note, 42.8% (6/14) had associated systemic autoimmune antibodies such as ANA, RA, and anti-Ro antibodies, whereas 36% (5/14) patients had associated interstitial lung disease (ILD). (nih.gov)
In a proportion of patients, it is associated with serological markers of autoimmune disorders and interstitial lung disease. (nih.gov)
Lung disease - Interstitial lung disease (inflammation of lung tissue) occurs most commonly in patients with antisynthetase antibodies in their blood. (medilib.ir)
The systemic involvement of polymyositis includes interstitial lung disease (ILD) and heart disease, such as heart failure and conduction abnormalities. (wikipedia.org)
Nintedanib is indicated to slow the rate of decline in pulmonary function in patients who have interstitial lung disease (ILD) associated with scleroderma. (medscape.com)
Many patients with an idiopathic interstitial pneumonia (IIP) have clinical features that suggest an underlying autoimmune process but do not meet established criteria for a connective tissue disease (CTD). (ersjournals.com)
The "European Respiratory Society/American Thoracic Society Task Force on Undifferentiated Forms of Connective Tissue Disease-associated Interstitial Lung Disease" was formed to create consensus regarding the nomenclature and classification criteria for patients with IIP and features of autoimmunity. (ersjournals.com)
The primary objective of this multidisciplinary task force was to develop consensus surrounding the nomenclature and classification of patients with suggestive forms of connective tissue disease-associated interstitial lung disease (CTD-ILD). (ersjournals.com)
Positive Association between ANKRD55 Polymorphism 7731626 and Dermatomyositis/Polymyositis with Interstitial Lung Disease in Chinese Han Population. (nih.gov)
To compare survival of patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) versus idiopathic pulmonary fibrosis (IPF) and patients with systemic sclerosis-associated ILD (SSc-ILD) versus other CTD-ILD followed at our center. (jrheum.org)
Role of endothelial damage in the pathogenesis of interstitial pneumonitis in patients with polymyositis and dermatomyositis. (jrheum.org)
There can be skin features, arthritis, and sometimes these patients have interstitial lung disease. (medscape.com)
Dr Christopher-Stine said she does an initial CT of the chest, abdomen, and pelvis for pretty much all her patients because they can have cancers or interstitial lung disease. (medscape.com)
these patients can have aggressive interstitial lung disease. (mhmedical.com)
BACKGROUND: Although patients with interstitial pneumonia pattern (ILD-UIP) and acute exacerbation (AE) leading to severe acute respiratory failure may require invasive mechanical ventilation (MV), physiological data on lung mechanics during MV are lacking. (bvsalud.org)

The Center for Pediatric Rheumatology at Cleveland Clinic Children's is dedicated to providing cutting-edge, patient-centered care to children with a broad range of rheumatologic conditions. (clevelandclinic.org)
Functional health literacy of patients with rheumatoid arthritis attending a community-based rheumatology practice. (jrheum.org)
Patients - Methods: We conducted a multicentre cross-sectional survey in the departments of Internal Medicine, Rheumatology and Nephrology in Dakar. (bvsalud.org)

Creatine kinase is a muscle enzyme that has been reported at various levels in different studies involving patients with amyotrophic lateral sclerosis. (lww.com)
In the present retrospective case-control study, we included 582 patients with amyotrophic lateral sclerosis and 582 age- and sex-matched healthy controls. (lww.com)
Serum creatine kinase levels in patients with amyotrophic lateral sclerosis were significantly higher than those in healthy controls. (lww.com)
Subgroup analysis revealed that serum creatine kinase levels in men were higher than those in women in both amyotrophic lateral sclerosis patients and healthy controls. (lww.com)
Compared with patients with bulbar-onset amyotrophic lateral sclerosis, patients with limb-onset amyotrophic lateral sclerosis had higher creatine kinase levels. (lww.com)
After adjusting for prognostic covariates, higher log creatine kinase values were correlated with higher overall survival in the amyotrophic lateral sclerosis patients. (lww.com)
Together, our results suggest that serum creatine kinase levels can be used as an independent factor for predicting the prognosis of amyotrophic lateral sclerosis patients. (lww.com)

Acthar is contraindicated in patients with scleroderma, osteoporosis, systemic fungal infections, ocular herpes simplex, recent surgery, history of or the presence of a peptic ulcer, congestive heart failure, uncontrolled hypertension, primary adrenocortical insufficiency, adrenocortical hyperfunction or sensitivity to proteins of porcine origins. (mallinckrodt.com)

Bohan and Peter and Targoff criteria were used for the diagnosis of polymyositis. (nih.gov)
Because of the pattern of weakness, cervicobrachial polymyositis tends to be confused with other common neurological conditions having upper girdle weakness, leading to delay in the diagnosis of this potentially treatable condition. (nih.gov)
In total, 75 patients had a diagnosis of DM/PM (median age: 60 [Q1-Q3: 41.3-70.2] years and median follow-up: 3.5 [Q1-Q3: 1-5.9] years) and 16 patients had cancer. (univ-tours.fr)
The contradictory results in these studies may be related to differences in the patient populations with respect to CTD diagnosis. (jrheum.org)
Specialist rehabilitation services play a key role in the prevention, diagnosis and treatment, and rehabilitation management of patients with disabling neurological conditions. (kch.nhs.uk)
By raising awareness, we hope to help affected patients reach diagnosis and treatment more quickly. (myositis.org)
Polymyositis is a severe condition that can lead to disability, so early diagnosis and treatment are essential. (carosp.com)

CTD associated with ILD include systemic sclerosis (SSc), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), polymyositis and dermatomyositis (PM/DM), Sjögren's syndrome, and mixed connective tissue disease (MCTD) 4 . (jrheum.org)
The DAS is the most specific measure, but a patient questionnaire is the most informative measure to assess rheumatoid arthritis. (jrheum.org)
A phase I study assessing the safety, clinical response, and pharmacokinetics of an experimental infliximab formulation for subcutaneous or intramuscular administration in patients with rheumatoid arthritis. (jrheum.org)
Parvovirus B19 infection in patients with rheumatoid arthritis in Taiwan. (jrheum.org)
rheumatoid arthritis, juvenile rheumatoid arthritis and ankylosing spondylitis to tide patients over an acute episode or exacerbation. (mallinckrodt.com)

To characterize and analyze a subgroup of patients with polymyositis presented with predominant or isolated proximal upper limb and neck weakness. (nih.gov)
A subgroup of patients were randomized to perform a 12-week endurance training program (exercise group, n = 9) or to a non-exercising control group ( n = 6). (biomedcentral.com)

Four other patients (5.5%) improved, although they still experienced mild dysphagia intermittently. (qxmd.com)
Dysphagia (difficulty swallowing) or other problems with esophageal motility occur in as many as 1/3 of patients. (wikipedia.org)

KEYTRUDA was also granted accelerated approval in September 2019, and received full approval in July 2021, in combination with LENVIMA ® (lenvatinib) for the treatment of patients with advanced endometrial carcinoma that is not MSI-H or dMMR, who have disease progression following prior systemic therapy in any setting and are not candidates for curative surgery or radiation. (businesswire.com)

To analyse the prognostic outcome factors in polymyositis and adult dermatomyositis. (bmj.com)
In this study, we assessed the long-term outcome of a large group of adult patients with polymyositis and dermatomyositis, including survival, development of associated disorders, clinical condition and course, and prognostic factors. (bmj.com)
KEYTRUDA is approved for the treatment of adult and pediatric patients with unresectable or metastatic MSI-H or dMMR solid tumors that have progressed following prior treatment and who have no satisfactory alternative treatment options. (businesswire.com)
The Ontario Ward provides a 14 bed specialist level 2B rehabilitation service offering rehabilitation for adult patients recovering from acquired neurological disability, from across South East London. (kch.nhs.uk)
Recommended Dosage in Patients with Renal Impairment: Dose adjustment may be necessary in adult patients with renal impairment. (drugs.com)

These patients may develop a cough and shortness of breath with exertion that ranges from mild symptoms to severe, progressive respiratory distress. (medilib.ir)
The patient did not have respiratory symptoms at admission. (cdc.gov)
Immediately evaluate patients with signs or symptoms of hepatitis or allergic reaction. (drugs.com)
There is no cure for polymyositis, but treatment can help to improve symptoms and quality of life. (carosp.com)
A few key signs and symptoms can help you know if you have polymyositis. (carosp.com)
There is no one definite cure for polymyositis as of now, but treatment can help to reduce symptoms and improve quality of life. (carosp.com)
In it, the specialists check the symptoms that the patient may feel, their clinical history, and their antecedents (family members who may have suffered from the same ailment). (steptohealth.com)
Patients may experience many skin symptoms. (msdmanuals.com)

Seventy-three patients with steroid-refractory esophageal involvement related to PM/DM received IVIG therapy (2 gm/kg monthly). (qxmd.com)
We also suggest that combined therapy of IVIG and high-dose steroids may be the first-line therapy in PM/DM patients with life-threatening esophageal manifestations. (qxmd.com)
KEYTRUDA plus chemotherapy is the first anti-PD1 therapy approved in Europe in this first-line setting, allowing these patients to be treated with immunotherapy earlier in the course of their treatment," said Dr. Scot Ebbinghaus, vice president, clinical research, Merck Research Laboratories. (merck.com)
KEYNOTE-158 (ClinicalTrials.gov, NCT02628067 ) is an ongoing global, open-label, non-randomized, multi-cohort, multi-center, Phase 2 study evaluating KEYTRUDA in patients with multiple types of advanced solid tumors - including endometrial carcinoma - that have progressed on standard of care therapy. (businesswire.com)
REGENXBIO Inc. is conducting a phase I, first-in-human, multicenter, open-label, dose escalation study of RGX-111 gene therapy in patients with MPS I. Two, one time doses of RGX-111 will be studied in approximately 5 patients age 6 years or older. (rarediseases.org)
MRK ), known as MSD outside of the United States and Canada, and Eisai today provided updates on two Phase 3 trials, LEAP-006 and LEAP-008, evaluating KEYTRUDA, Merck's anti-PD-1 therapy, plus LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, in patients with certain types of metastatic non-small cell lung cancer. (streetinsider.com)
Monitor patients intensively during the first 18 weeks of therapy with nevirapine to detect potentially life-threatening hepatotoxicity or skin reactions. (drugs.com)
The effect of cyclophosphamide therapy on longterm survival in patients with SSc-ILD is still unclear. (jrheum.org)
Stress the need for close follow-up care, continued physical therapy, and long-term therapy, and warn patients regarding adverse events related to medications. (medscape.com)
We provide inpatient rehabilitation for patients who are 16 or over with complex neurological disabilities (a physical disability, often with cognitive and/or communication problems) who require more than one intensive therapy discipline (occupational therapy, physiotherapy or speech and language therapy) and/or psychology. (kch.nhs.uk)
Use during an exacerbation or as maintenance therapy in selected cases of systemic dermatomyositis (polymyositis). (mallinckrodt.com)
Female patients with evidence of either locally advanced (not amenable to radiation therapy or surgery in a curative intent), inoperable, and/or metastatic disease who have either progressed, recurred after standard of care treatment, have refused, or are otherwise ineligible for standard of care treatment. (who.int)
For patients who received immunotherapy (including anti-programmed death-1 [anti-PD-1] therapy) a washout of at least a 4-week recovery period is required. (who.int)

Questionnaires inquiring about patients with DM, PM, systemic lupus erythematosus, progressive systemic sclerosis and noninflammatory neuromuscular diseases were distributed to the main medical institutes in Japan. (nih.gov)
XRCC1 variants do not represent a risk for dermatomyositis and systemic lupus erythematosus in Bulgarian patients. (cdc.gov)

Patients with polymyositis, presenting with predominant or isolated weakness of upper limbs and the neck, were included. (nih.gov)
All patients developed progressive symmetrical weakness predominantly affecting upper limbs, and 50% (7/14) had weakness only in upper limbs. (nih.gov)
Weakness in the neck and shoulder region was the most common presenting complaints, presenting in 71.4% (10/14) and 64.3% (9/14) of patients, respectively, followed by neck and shoulder pain in 57.14% (8/14) patients. (nih.gov)
Cervicobrachial polymyositis presents with predominant or isolated proximal upper limb and neck weakness. (nih.gov)
Patients often have weakness and an inability to perform activities such as rising from chairs, climbing stairs, or bringing their arms over their heads. (livestrong.com)
Muscle weakness - Typically patients develop painless weakness of the proximal muscles-the large muscle groups of the upper arms, thighs, neck, and trunk-in a symmetric pattern affecting both sides of the body. (medilib.ir)
As a result of weakness in these muscles, some patients will develop difficulty swallowing or may aspirate food into the lungs, which can lead to pneumonia. (medilib.ir)
The hallmark of polymyositis is weakness and/or loss of muscle mass in the proximal musculature, as well as flexion of the neck and torso. (wikipedia.org)
Polymyositis tends to become evident in adulthood, presenting with bilateral proximal muscle weakness often noted in the upper legs due to early fatigue while walking. (wikipedia.org)
This randomized, controlled study on patients with polymyositis or dermatomyositis was based on three hypotheses: patients display impaired endurance due to reduced aerobic capacity and muscle weakness, endurance training improves their exercise performance by increasing the aerobic capacity, and endurance training has general beneficial effects on their health status. (biomedcentral.com)
argenx BVBA is conducting a long-term, single-arm, open-label, multicenter phase 3 follow-on trial of the ARGX-113-1704 study to evaluate the safety and tolerability of ARGX-113 in patients who have myasthenia gravis with generalized muscle weakness. (rarediseases.org)
In terms of the muscle testing specifically, if you are assessing weakness of the neck or the extension and flexion of the hip, you want the patient lying down because otherwise they can recruit other muscle groups. (medscape.com)
Meanwhile, complications from polymyositis may result from severe and progressive muscle weakness or complications such as cardiac or pulmonary involvement. (carosp.com)
Polymyositis is a rare inflammatory muscle disease that can cause muscle weakness and disability. (carosp.com)
Polymyositis and dermatomyositis are systemic disorders of unknown cause whose principal manifestation is muscle weakness. (mhmedical.com)

Intravenous immunoglobulins for steroid-refractory esophageal involvement related to polymyositis and dermatomyositis: a series of 73 patients. (qxmd.com)
To assess the long-term outcome of esophageal complications in the group of patients receiving intravenous immunoglobulins (IVIG) for the treatment of severe steroid-refractory esophageal involvement related to polymyositis/dermatomyositis (PM/DM). (qxmd.com)
We retrospectively reviewed the medical records of 73 patients (39 with PM, 34 with DM) with steroid-resistant esophageal involvement. (qxmd.com)
The skin involvement of dermatomyositis is absent in polymyositis. (wikipedia.org)

METHODS: Partitioned lung and chest wall mechanics were assessed in a series of AE-ILD-UIP patients matched 1:1 with primary ARDS as controls (based on BMI and PaO2/FiO2 ratio). (bvsalud.org)

Patients with this condition should also be evaluated for giant cell arteritis, which can cause blindness if not treated promptly, because the arteritis is often associated with this condition. (livestrong.com)

The inflammation of polymyositis is mainly found in the endomysial layer of skeletal muscle, whereas dermatomyositis is characterized primarily by inflammation of the perimysial layer of skeletal muscles. (wikipedia.org)
They seem to be pretty sensitive, and most patients with something autoimmune or inflammation going on have anemia. (medscape.com)
Polymyositis is a rare or infrequent disease that involves the inflammation of an area of the body. (steptohealth.com)

Histopathology of polymyositis showing endomysial mononuclear inflammatory infiltrate and muscle fiber necrosis. (medscape.com)

Polymyositis is an immune-mediated syndrome secondary to defective cellular immunity that is most commonly associated with other systemic autoimmune diseases. (medscape.com)
Dr. Adenwalla and her team provide the best possible care for their patients with autoimmune diseases. (carosp.com)

Association between the BANK1 rs3733197 polymorphism and polymyositis/dermatomyositis in a Chinese Han population. (cdc.gov)

Neutrophil-to-lymphocyte ratio (NLR) is increased and associated with overall survival (OS) in inflammatory diseases including dermatomyositis/polymyositis (DM/PM) and many cancers. (univ-tours.fr)
We have seen few advances over the last three decades that have improved historically poor survival outcomes for patients with esophageal cancer," said Professor Antoine Adenis, Department of Medical Oncology, Montpellier Cancer Institute, France. (merck.com)
The European Commission's approval of KEYTRUDA plus chemotherapy for the treatment of certain patients with esophageal and HER2-negative GEJ cancer provides a new option in the first-line setting that has shown significant improvements in progression-free and overall survival. (merck.com)
Patients with SSc-ILD (n = 24) experienced better survival than those with other CTD-ILD (n = 38), with 1-year, 3-year, and 5-year survival rates of 100%, 90%, and 77%, respectively, versus 78%, 42%, and 38% (p = 0.01). (jrheum.org)
Survival in patients with SSc-ILD was better than in patients with other CTD-ILD, potentially related to routine screening for and early detection of ILD in patients with SSc at our center. (jrheum.org)
Several studies comparing IPF with CTD-ILD indicate that patients with IPF experience poorer outcomes and survival 6 , 7 , 8 . (jrheum.org)
We compared the clinical features and survival of patients with SSc-ILD to those with ILD associated with other CTD (non-SSc CTD-ILD), including RA, SLE, PM/DM, Sjögren's syndrome, and MCTD. (jrheum.org)
Patients with severe TR-ILD had worse overall survival than those without, whereas high baseline KL-6 level was associated with worse survival, especially in patients without severe TR-ILD. (bvsalud.org)

If your patient lives outside the Metro North Health area and you wish to refer them to one of our services, inclusion of information regarding their particular medical and social factors will assist with the triaging of your referral. (qld.gov.au)

Another common symptom of polymyositis is muscle pain. (carosp.com)

The referring diagnoses in all 14 patients were other than polymyositis, for example, motor neuron disease, cervical radiculopathy, brachial neuritis, chronic inflammatory demyelinating polyradiculoneuropathy, anti-MuSK myasthenia gravis, and facioscapulohumeral muscular dystrophy. (nih.gov)
High serum CK levels are related to myopathic disorders, including polymyositis and muscular dystrophy (Munsat et al. (lww.com)
In his neuromuscular program, he included patients not only with muscular dystrophy or mitochondrial myopathies but all aspects of the neuromuscular disorders. (childneurologysociety.org)

Disease-related death occurred in at least 10% of the patients, mainly because of associated cancer and pulmonary complications. (bmj.com)
Therefore, guidelines have been published recommending that all patients with SSc undergo baseline and annual screening for ILD with pulmonary function testing and chest imaging 13 , 14 . (jrheum.org)

Fortunately, most patients with this form of muscle disease recover completely. (livestrong.com)
However, patients with an atypical disease presentation, particularly those with early-stage disease, can be challenging to diagnose. (nature.com)
While these results are not what we hoped for, we are proud of the foundational role that KEYTRUDA has established in the treatment of certain types of lung cancer, and we are committed to continuing to research how we can further improve responses to our medicines for patients with difficult-to-treat forms of the disease. (streetinsider.com)
Patients with polymyositis should be educated early about the disease and should be provided with realistic expectations about outcomes. (medscape.com)
To tide the patient over a critical period of the disease in regional enteritis and ulcerative colitis. (nih.gov)
We provide intensive inpatient neuro-rehabilitation for patients recovering from a severe neurological event such as brain injury, disease, or trauma who need specialist care to aid their recovery. (kch.nhs.uk)
Maraviroc tablets are contraindicated in patients with severe renal impairment or end-stage renal disease (ESRD) (CrCl less than 30 mL per minute) who are concomitantly taking potent CYP3A inhibitors or inducers. (drugs.com)
We are proud to have partnered with eight other organizations representing patients affected by ILD to educate people about the disease. (myositis.org)
Polymyositis is a rare chronic inflammatory muscle disease that occurs when the body's immune system attacks healthy muscle tissue. (carosp.com)
Polymyositis is a disease with good therapeutic prospects for the future. (steptohealth.com)
Forty patients with chronic liver disease, who were seronegative for hepatitis B surface antigen and antibody to HCV, were followed for a mean period of 72 months. (go.jp)
The clinical manifestations in these patients were compared with those reported for type B and type C chronic liver disease. (go.jp)
However, in patients with asymptomatic disease, the best timing to start treatment can be difficult to determine. (bvsalud.org)

MRI of the cervicobrachial region was performed in the first 6 patients showing T2 hyper intensities (6/6) and contrast enhancement (4/4) of clinically affected muscles. (nih.gov)
Thus it has widespread clinical research implications for patients with disorders affecting the oral peripheral muscles, salivary gland flow and the central nervous system control of speech and swallowing. (knowcancer.com)
The skeletal muscles are more affected than others and that's why the patient is unable to walk properly and feels difficulty in doing daily routine work. (planetayurveda.com)

Re-examination of 110 patients after a median follow-up of 5 years showed that 20% remained in remission and were off drugs, whereas 80% had a polycyclic or chronic continuous course. (bmj.com)
A database of 400 patients with chronic HCV in Qatar was retrospectively analysed: 242 patients underwent antiviral treatment, of whom 212 (87.6%) were naïve to treatment. (who.int)
Validity of screening tests for Sjögren's syndrome in ambulatory patients with chronic diseases. (jrheum.org)
Of the 40 patients, 22 were diagnosed with chronic hepatitis, 14 with liver cirrhosis and 4 with hepatocellular carcinoma (HCC). (go.jp)
The yearly incidence of HCC was 9.7% in patients with liver cirrhosis and 3.9% in chronic hepatitis. (go.jp)

The pathogenesis of polymyositis points toward a T-cell-mediated cytotoxic process directed against unidentified muscle antigens. (medscape.com)

Although polymyositis and dermatomyositis are regarded as treatable disorders, prognosis is not well known, as in the literature long-term outcome and prognostic factors vary widely. (bmj.com)
He molded his neuromuscular clinic into a comprehensive, multi-disciplinary program that was a regional magnet for patients of all ages, newborn to elder, suffering from all types of neuromuscular disorders. (childneurologysociety.org)

Our facility may offer patients the opportunity to participate in state-of-the-art clinical trials for juvenile arthritis and vasculitis . (clevelandclinic.org)
Laboratory and imaging studies used by French rheumatologists to evaluate patients with early arthritis. (jrheum.org)

Indeed, up to one patient in four with dermatomyositis has an occult malignancy. (mhmedical.com)

Studies so far have yielded less favorable results than treatment for polymyositis and dermatomyositis. (medscape.com)
The results emphasize the importance of endurance exercise in addition to immunosuppressive treatment of patients with polymyositis or dermatomyositis. (biomedcentral.com)
Despite recommended treatment with high doses of glucocorticoids and immunosuppressive agents, few patients can regain their former muscle performance and the reason for this is not fully understood [ 6 , 7 ]. (biomedcentral.com)
Providing patients compassionate care and comprehensive treatment of diseases affecting the joints and connective tissues. (uab.edu)
Patients in Europe with MSI-H/dMMR colorectal cancer have had only chemotherapy-containing regimens available to them in the first-line treatment setting and have historically faced poor outcomes," said Dr. Vicki Goodman, vice president, clinical research, Merck Research Laboratories. (merck.com)
KEYTRUDA is indicated for the treatment of patients with unresectable or metastatic melanoma. (merck.com)
KEYTRUDA monotherapy is already playing a role for the treatment of certain patients with advanced endometrial carcinoma through the tumor-agnostic MSI-H indication which received accelerated approval four years ago. (businesswire.com)
Check transaminase levels immediately for all patients who develop a rash during the first 18 weeks of treatment. (drugs.com)
Most patients show significant improvement with treatment. (medscape.com)
Maraviroc tablet is a CCR5 co-receptor antagonist indicated in combination with other antiretroviral agents for the treatment of only CCR5-tropic HIV-1 infection in adults and pediatric patients 2 years of age and older weighing at least 10 kg. (drugs.com)
Prior to initiation of maraviroc tablets for treatment of HIV-1 infection, test all patients for CCR5 tropism using a highly sensitive tropism assay. (drugs.com)
Therefore, in patients with renal impairment [HA552 trade name] should only be used if the potential benefits of treatment are considered to outweigh the potential risks. (who.int)
These dose adjustments have not been confirmed in clinical studies and the clinical response to treatment should be closely monitored in such patients (see sections 4.4 and 5.2). (who.int)
The effect of cromolyn sodium is usually evident after several weeks of treatment, although some patients show an almost immediate response. (nih.gov)
With early treatment, a person with polymyositis can go into remission. (carosp.com)
Mallinckrodt has just completed such a process for a small Phase 4 pilot study that was begun by previous owners to generate potential new insights into the use of H.P. Acthar Gel in treatment of idiopathic Membranous Nephropathy (iMN), specifically in refractory patients who had failed previous immunosuppressive therapies. (mallinckrodt.com)
In most cases, patients present to a clinician with a history of recurrent infections, and treatment is indicated. (bvsalud.org)
We recruited patients with lung cancer in whom KL-6 was measured to differentiate between pneumonia and ILD (category 1), diagnose and assess the severity of suspicious ILD (category 2), or evaluate baseline levels before cancer treatment (category 3). (bvsalud.org)

The effect of cigarette smoking on the clinical and serological phenotypes of polymyositis and dermatomyositis. (cdc.gov)

Up to 20% of cancer patients experience paraneoplastic syndromes, but often these syndromes are unrecognized. (msdmanuals.com)

Conclusion : La pandémie de covid-19 a eu un impact non négligeable sur le suivi des patients atteints de maladies inflammatoires systémiques. (bvsalud.org)
Conclusion: The covid-19 pandemic has had a significant impact on the follow-up of patients with systemic inflammatory diseases. (bvsalud.org)

33 patients (45.2%) with esophageal impairment developed aspiration pneumonia. (qxmd.com)
Sixty patients (82.2%) exhibited resolution of esophageal clinical manifestations, leading to a return to normal oral feeding and ablation of feeding enteral tubes. (qxmd.com)
The approval was based on data from KEYNOTE-590 ( NCT03189719 ), a multicenter, randomized, double-blind placebo-controlled trial that enrolled 749 patients with locally advanced unresectable or metastatic esophageal or GEJ carcinoma (Siewert Type I) who were not candidates for surgical resection or definitive chemoradiation. (merck.com)

Patients with some inflammatory and connective tissue diseases are at a higher risk for ILD. (myositis.org)

We also identified factors predictive of mortality in patients with CTD-ILD. (jrheum.org)
Mortality in Patients with Polymyositis and Dermatomyositis in an Israeli Population. (cdc.gov)

Patients may notice difficulty rising from a chair, climbing stairs, or performing tasks overhead such as reaching up to a high shelf, while grip strength remains normal. (medilib.ir)

The changes in the lung tissue can also cause a dry, hacky cough for some patients. (stanford.edu)

At the study's final analysis, there was not an improvement in OS for patients treated with KEYTRUDA plus LENVIMA with chemotherapy compared to KEYTRUDA with chemotherapy. (streetinsider.com)

We remain committed to making a difference in the lives of these very sick patients, as evidenced by the initiation of the largest FSGS clinical trial ever conducted, as well as fifteen Investigator Initiated research studies developing data on Acthar's utility across a broad spectrum of nephrotic syndrome etiologies, including recurrent post-transplant FSGS. (mallinckrodt.com)

It is estimated approximately 5-15% of colorectal cancer patients have tumors that score as either MSI-H or dMMR when testing is performed. (merck.com)
We plan to compare ultrasound evaluation of tumor staging, tumor volume, and tumor recurrence in patients with tumors of the larynx, oral cavity and hypopharynx. (knowcancer.com)
Patients will be seen who are enrolled in NCI and NIDCD protocols for head and neck tumors. (knowcancer.com)

Polymyositis and dermatomyositis have many shared clinical features. (medscape.com)

Celgene is conducting a clinical trial of fedratinib in patients with DIPSS (dynamic international prognostic scoring system)-intermediate or high- risk primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (post-PV MF), or post-essential thrombocythemia myelofibrosis (post-ET MF) and previously treated with Ruxolitinib to evaluate the percentage of patients with at least a 35% reduction of spleen volume and to evaluate the safety of fedratinib. (rarediseases.org)

In addition, CHART data did reveal durable efficacy as demonstrated by sustained remission through Week 48 in a small subset of patients, consistent with that seen in other datasets. (mallinckrodt.com)

People with polymyositis who also have cancer generally have a worse prognosis. (carosp.com)

Severe and potentially life-threatening skin and hypersensitivity reactions have been reported in patients taking maraviroc. (drugs.com)
If patients with severe renal impairment or ESRD receiving maraviroc (without concomitant CYP3A inducers or inhibitors) experience postural hypotension, the dose of maraviroc should be reduced from 300 mg twice daily to 150 mg twice daily. (drugs.com)

The establishment of classification criteria for polymyositis (PM) and dermatomyositis (DM). (nih.gov)

Anatomy2

Diseases16

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Polymyositis

Dermatomyositis

Myositis

Histidine-tRNA Ligase

Lung Diseases, Interstitial

Myositis, Inclusion Body

Prednisolone

Muscular Diseases

Autoantibodies

Paraneoplastic Syndromes

Creatine Kinase

Muscles

Connective Tissue Diseases

Muscle, Skeletal

Scleroderma, Systemic

Myoglobinuria

Nervous System Autoimmune Disease, Experimental

Autoimmune Diseases

Mediastinal Emphysema

Antibodies, Antinuclear

Muscle Weakness

Muscular Dystrophies

Immunosuppressive Agents

Mixed Connective Tissue Disease

Polymyositis

Exercise therapy for idiopathic inflammatory myopathies

Inclusion body myositis

List of autoimmune diseases

Masticatory force

Exosome complex

C1D

Troponin

Exosome component 10

Exosome component 9

PMS1

Neuropathology

Scleromyositis

C-reactive protein

Blood flow restriction training

Antisynthetase syndrome

Interferon alpha-1

Foot drop

Mixed connective tissue disease

Palindromic rheumatism

Ku80

1000minds

Overlap syndrome

Myopathy

Dysphagia

Kikuchi disease

Anti-topoisomerase antibodies

Ken Strauss

Sifalimumab

Thymoma

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