Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Systematic discussions and teaching relating to patient care.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Elements of limited time intervals, contributing to particular results or situations.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Prenatal interventions to correct fetal anomalies or treat FETAL DISEASES in utero. Fetal therapies include several major areas, such as open surgery; FETOSCOPY; pharmacological therapy; INTRAUTERINE TRANSFUSION; STEM CELL TRANSPLANTATION; and GENETIC THERAPY.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Genotypic differences observed among individuals in a population.
Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The introduction of error due to systematic differences in the characteristics between those selected and those not selected for a given study. In sampling bias, error is the result of failure to ensure that all members of the reference population have a known chance of selection in the sample.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Surgical insertion of synthetic material to repair injured or diseased heart valves.
Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Procedures that avoid use of open, invasive surgery in favor of closed or local surgery. These generally involve use of laparoscopic devices and remote-control manipulation of instruments with indirect observation of the surgical field through an endoscope or similar device.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The plan and delineation of prostheses in general or a specific prosthesis.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Tumors or cancer of the LIVER.
The restoration of the sequential order of contraction and relaxation of the HEART ATRIA and HEART VENTRICLES by atrio-biventricular pacing.
A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.
The discipline studying genetic composition of populations and effects of factors such as GENETIC SELECTION, population size, MUTATION, migration, and GENETIC DRIFT on the frequencies of various GENOTYPES and PHENOTYPES using a variety of GENETIC TECHNIQUES.
The return of a sign, symptom, or disease after a remission.
Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.
The use of freezing as a special surgical technique to destroy or excise tissue.
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
The relationships of groups of organisms as reflected by their genetic makeup.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.
The excision of the thickened, atheromatous tunica intima of a carotid artery.
Surgical insertion of a prosthesis.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Excision of all or part of the liver. (Dorland, 28th ed)
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
The transference of a part of or an entire liver from one human or animal to another.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Methods of creating machines and devices.
Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Tumors or cancer of the LUNG.
Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.
Surgery performed on the nervous system or its parts.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
Surgical reconstruction of a joint to relieve pain or restore motion.
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children.
Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
The excision of lung tissue including partial or total lung lobectomy.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Developmental abnormalities in any portion of the ATRIAL SEPTUM resulting in abnormal communications between the two upper chambers of the heart. Classification of atrial septal defects is based on location of the communication and types of incomplete fusion of atrial septa with the ENDOCARDIAL CUSHIONS in the fetal heart. They include ostium primum, ostium secundum, sinus venosus, and coronary sinus defects.
Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.
Complete or partial surgical removal of the prostate. Three primary approaches are commonly employed: suprapubic - removal through an incision above the pubis and through the urinary bladder; retropubic - as for suprapubic but without entering the urinary bladder; and transurethral (TRANSURETHRAL RESECTION OF PROSTATE).
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
The selection or choice of sexual partner in animals. Often this reproductive preference is based on traits in the potential mate, such as coloration, size, or behavioral boldness. If the chosen ones are genetically different from the rejected ones, then NATURAL SELECTION is occurring.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.

Geographic, demographic, and socioeconomic variations in the investigation and management of coronary heart disease in Scotland. (1/7350)

OBJECTIVE: To determine whether age, sex, level of deprivation, and area of residence affect the likelihood of investigation and treatment of patients with coronary heart disease. DESIGN, PATIENTS, AND INTERVENTIONS: Routine discharge data were used to identify patients admitted with acute myocardial infarction (AMI) between 1991 and 1993 inclusive. Record linkage provided the proportion undergoing angiography, percutaneous transluminal coronary angioplasty (PTCA), and coronary artery bypass grafting (CABG) over the following two years. Multiple logistic regression analysis was used to determine whether age, sex, deprivation, and area of residence were independently associated with progression to investigation and revascularisation. SETTING: Mainland Scotland 1991 to 1995 inclusive. MAIN OUTCOME MEASURES: Two year incidence of angiography, PTCA, and CABG. Results-36 838 patients were admitted with AMI. 4831 (13%) underwent angiography, 587 (2%) PTCA, and 1825 (5%) CABG. Women were significantly less likely to undergo angiography (p < 0.001) and CABG (p < 0.001) but more likely to undergo PTCA (p < 0.05). Older patients were less likely to undergo all three procedures (p < 0.001). Socioeconomic deprivation was associated with a reduced likelihood of both angiography and CABG (p < 0.001). There were significant geographic variations in all three modalities (p < 0.001). CONCLUSION: Variations in investigation and management were demonstrated by age, sex, geography, and socioeconomic deprivation. These are unlikely to be accounted for by differences in need; differences in clinical practice are, therefore, likely.  (+info)

Early death during chemotherapy in patients with small-cell lung cancer: derivation of a prognostic index for toxic death and progression. (2/7350)

Based on an increased frequency of early death (death within the first treatment cycle) in our two latest randomized trials of combination chemotherapy in small-cell lung cancer (SCLC), we wanted to identify patients at risk of early non-toxic death (ENTD) and early toxic death (ETD). Data were stored in a database and logistic regression analyses were performed to identify predictive factors for early death. During the first cycle, 118 out of 937 patients (12.6%) died. In 38 patients (4%), the cause of death was sepsis. Significant risk factors were age, performance status (PS), lactate dehydrogenase (LDH) and treatment with epipodophyllotoxins and platinum in the first cycle (EP). Risk factors for ENTD were age, PS and LDH. Extensive stage had a hazard ratio of 1.9 (P = 0.07). Risk factors for ETD were EP, PS and LDH, whereas age and stage were not. For EP, the hazard ratio was as high as 6.7 (P = 0.0001). We introduced a simple prognostic algorithm including performance status, LDH and age. Using a prognostic algorithm to exclude poor-risk patients from trials, we could minimize early death, improve long-term survival and increase the survival differences between different regimens. We suggest that other groups evaluate our algorithm and exclude poor prognosis patients from trials of dose intensification.  (+info)

Peritoneal cytology in the surgical evaluation of gastric carcinoma. (3/7350)

Many patients undergoing surgery for gastric carcinoma will develop peritoneal metastases. A method to identify those patients at risk of peritoneal recurrence would help in the selection of patients for adjuvant therapy. Peritoneal cytology has received little attention in the West, but may prove a useful additional means of evaluating patients with gastric cancer. The aims of this study were to evaluate sampling techniques for peritoneal cytology in patients with gastric cancer, to assess the prognostic significance of free peritoneal malignant cells and to discover the effect of the operative procedure on dissemination of malignant cells. The study is based on 85 consecutive patients undergoing surgical treatment of gastric cancer and followed up for 2 years or until death. Peritoneal cytology samples were collected at laparoscopy, and at operation prior to resection by intraperitoneal lavage and serosal brushings. After resection, samples were taken by peritoneal lavage, imprint cytology of the resected specimen and post-operatively by peritoneal irrigation via a percutaneous catheter. Malignant cells were diagnosed by two independent microscopists. Preoperative peritoneal lavage yielded malignant cells in 16 out of 85 cases (19%). The yield of free malignant cells was increased by using serosal brushings (by four cases) and imprint cytology (by two cases); all of the cases had evidence of serosal penetration. One serosa-negative case exhibited positive cytology in the post-resection peritoneal specimen in which the preresection cytology specimen was negative. Survival was worse in the cytology-positive group (chi2 = 25.1; P< 0.0001). Among serosa-positive patients, survival was significantly reduced if cytology was positive, if cases yielded by brushings and imprint cytology were included (log-rank test = 8.44; 1 df, P = 0.004). In conclusion, free peritoneal malignant cells can be identified in patients with gastric cancer who have a poor prognosis; the yield can be increased with brushings and imprint cytology in addition to conventional peritoneal lavage. Evaluation of peritoneal cytology by these methods may have a role in the selection of patients with the poorest prognosis who may benefit most from adjuvant therapy.  (+info)

Profound variation in dihydropyrimidine dehydrogenase activity in human blood cells: major implications for the detection of partly deficient patients. (4/7350)

Dihydropyrimidine dehydrogenase (DPD) is responsible for the breakdown of the widely used antineoplastic agent 5-fluorouracil (5FU), thereby limiting the efficacy of the therapy. To identify patients suffering from a complete or partial DPD deficiency, the activity of DPD is usually determined in peripheral blood mononuclear cells (PBM cells). In this study, we demonstrated that the highest activity of DPD was found in monocytes followed by that of lymphocytes, granulocytes and platelets, whereas no significant activity of DPD could be detected in erythrocytes. The activity of DPD in PBM cells proved to be intermediate compared with the DPD activity observed in monocytes and lymphocytes. The mean percentage of monocytes in the PBM cells obtained from cancer patients proved to be significantly higher than that observed in PBM cells obtained from healthy volunteers. Moreover, a profound positive correlation was observed between the DPD activity of PBM cells and the percentage of monocytes, thus introducing a large inter- and intrapatient variability in the activity of DPD and hindering the detection of patients with a partial DPD deficiency.  (+info)

The effect of race and sex on physicians' recommendations for cardiac catheterization. (5/7350)

BACKGROUND: Epidemiologic studies have reported differences in the use of cardiovascular procedures according to the race and sex of the patient. Whether the differences stem from differences in the recommendations of physicians remains uncertain. METHODS: We developed a computerized survey instrument to assess physicians' recommendations for managing chest pain. Actors portrayed patients with particular characteristics in scripted interviews about their symptoms. A total of 720 physicians at two national meetings of organizations of primary care physicians participated in the survey. Each physician viewed a recorded interview and was given other data about a hypothetical patient. He or she then made recommendations about that patient's care. We used multivariate logistic-regression analysis to assess the effects of the race and sex of the patients on treatment recommendations, while controlling for the physicians' assessment of the probability of coronary artery disease as well as for the age of the patient, the level of coronary risk, the type of chest pain, and the results of an exercise stress test. RESULTS: The physicians' mean (+/-SD) estimates of the probability of coronary artery disease were lower for women (probability, 64.1+/-19.3 percent, vs. 69.2+/-18.2 percent for men; P<0.001), younger patients (63.8+/-19.5 percent for patients who were 55 years old, vs. 69.5+/-17.9 percent for patients who were 70 years old; P<0.001), and patients with nonanginal pain (58.3+/-19.0 percent, vs. 64.4+/-18.3 percent for patients with possible angina and 77.1+/-14.0 percent for those with definite angina; P=0.001). Logistic-regression analysis indicated that women (odds ratio, 0.60; 95 percent confidence interval, 0.4 to 0.9; P=0.02) and blacks (odds ratio, 0.60; 95 percent confidence interval, 0.4 to 0.9; P=0.02) were less likely to be referred for cardiac catheterization than men and whites, respectively. Analysis of race-sex interactions showed that black women were significantly less likely to be referred for catheterization than white men (odds ratio, 0.4; 95 percent confidence interval, 0.2 to 0.7; P=0.004). CONCLUSIONS: Our findings suggest that the race and sex of a patient independently influence how physicians manage chest pain.  (+info)

Studies on structural changes of the carotid arteries and the heart in asymptomatic renal transplant recipients. (6/7350)

BACKGROUND: The present study was designed to characterize early structural changes of large arteries in renal transplant recipients with no clinical evidence of cardiovascular disease and normal blood pressure values, and to analyse the relationship between arterial alterations and those of the heart. METHODS: Intima media thickness and atherosclerotic plaques of the carotid arteries as well as left ventricular geometry and function were examined in 35 asymtomatic renal transplant recipients and 29 age- and sex-matched healthy controls by high resolution B-mode ultrasound and by echocardiography. RESULTS: Intima-media thickness of the carotid arteries was significantly higher in renal transplant recipients (1.21+/-0.08 mm) than in healthy controls (0.74+/-0.04 mm) (P<0.001). Atherosclerotic plaques were found in the majority of renal transplant recipients (71% vs 14% in healthy controls, P<0.001). Left ventricular mass index was significantly increased in the group of renal transplant recipients (264+/-13 g, 146+/-7 g/m2) when compared with healthy controls (155+/-8 g, 83+/-4 g/m2) (P<0.001). Multiple regression analysis in renal transplant recipients showed that intima media thickness of the carotid arteries was significantly related to left ventricular mass index (P<0.02), but not to age, blood pressure, body mass index, serum creatinine, cholesterol and lipoprotein (a) levels. In the group of healthy controls, intima-media thickness of the carotid artery was related to age (P<0.002), but not to left ventricular mass index or the other independent variables. CONCLUSIONS: The present study documents pronounced intima-media thickening in asymptomatic renal transplant recipients. Atherosclerotic lesions are present in most renal transplant recipients with no clinical evidence of cardiovascular disease. We observed a parallelism between arterial wall thickening and left ventricular hypertrophy, although blood pressure levels were normal during haemodialysis therapy and after renal transplantation.  (+info)

Ruptured abdominal aortic aneurysms: selecting patients for surgery. (7/7350)

OBJECTIVES: Mortality from ruptured abdominal aortic aneurysm (RAAA) remains high. Despite this, withholding surgery on poor-prognosis patients with RAAA may create a difficult dilemma for the surgeon. Hardman et al. identified five independent, preoperative risk factors associated with mortality and proposed a model for preoperative patient selection. The aim of this study was to test the validity of the same model in an independent series of RAAA patients. METHODS: A consecutive series of patients undergoing surgery for RAAA was analysed retrospectively by case-note review. Thirty-day operative mortality and the presence of the five risk factors: age (> 76 years), creatinine (Cr) (> 190 mumol/l), haemoglobin (Hb) (< 9 g/dl), loss of consciousness and electrocardiographic (ECG) evidence of ischaemia were recorded for each patient. RESULTS: Complete data sets existed for 69 patients (mean age: 73 years, range: 38-86 years, male to female ratio: 6:1). Operative mortality was 43%. The cumulative effect of 0, 1 and 2 risk factors on mortality was 18%, 28% and 48%, respectively. All patients with three or more risk factors died (eight patients). CONCLUSIONS: These results lend support to the validity of the model. The potential to avoid surgery in patients with little or no chance of survival would spare unnecessary suffering, reduce operative mortality and enhance use of scarce resources.  (+info)

Repair of ruptured thoracoabdominal aortic aneurysm is worthwhile in selected cases. (8/7350)

INTRODUCTION: The risks and benefits of operating on patients with ruptured thoracoabdominal aortic aneurysm (TAAA) have not been defined. The aim of the present study is to report this unit's experience with operations performed for ruptured TAAA over a 10-year period. METHODS: Interrogation of a prospectively gathered computerised database. PATIENTS: Between 1 January 1983 and 30 June 1996, 188 consecutive patients with TAAA were operated on, of whom 23 (12%) were operated for rupture. RESULTS: There were nine survivors (40%). Patients whose preoperative systolic blood pressure remained above 100 mmHg were significantly more likely to survive (4/8 vs. 13/15, p = 0.03 by Fisher's exact test). Survival was also related to Crawford type: type I (two of three survived); II (none of six); III (two of six); and IV (five of eight). All non-type II, non-shocked patients survived operation. Survivors spent a median of 28 (range 10-66) postoperative days in hospital, of which a median of 6 (range 2-24) days were spent in the intensive care unit. Survivor morbidity comprised prolonged ventilation (> 5 days) (n = 3); tracheostomy (n = 1); and temporary haemofiltration (n = 2). No survivor developed paraplegia or required permanent dialysis. CONCLUSIONS: Patients in shock with a Crawford type II aneurysm have such a poor prognosis that intervention has to be questioned except in the most favourable of circumstances. However, patients with types I, III and IV who are not shocked on presentation can be salvaged and, where possible, should be transferred to a unit where appropriate expertise and facilities are available.  (+info)

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BACKGROUND: Randomized controlled trials (RCTs) are widely accepted as being the most efficient way of investigating the efficacy of psychological therapies. However, researchers conducting RCTs commonly report difficulties in recruiting an adequate sample within planned timescales. In an effort to overcome recruitment difficulties, researchers often are forced to expand their recruitment criteria or extend the recruitment phase, thus increasing costs and delaying publication of results. Research investigating the effectiveness of recruitment strategies is limited, and trials often fail to report sufficient details about the recruitment sources and resources utilized. PURPOSE: We examined the efficacy of strategies implemented during the Staying Well after Depression RCT in Oxford to recruit participants with a history of recurrent depression. METHODS: We describe eight recruitment methods utilized and two further sources not initiated by the research team and examine their efficacy in terms of (1) the
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Countries Compared by Education > High school enrolment rate. International Statistics at NationMaster.com, United Nations Educational, Scientific, and Cultural Organisation (UNESCO) Institute for Statistics. Aggregates compiled by NationMaster. Retrieved from http://www.nationmaster.com/country-info/group-stats/South-Asia/Education/High-school-enrolment-rate. Countries Compared by Education > High school enrolment rate. International Statistics at NationMaster.com, United Nations Educational, Scientific, and Cultural Organisation (UNESCO) Institute for Statistics. Aggregates compiled by NationMaster. 1990-2008. ,http://www.nationmaster.com/country-info/group-stats/South-Asia/Education/High-school-enrolment-rate,.. Countries Compared by Education > High school enrolment rate. International Statistics at NationMaster.com, United Nations Educational, Scientific, and Cultural Organisation (UNESCO) Institute for Statistics. Aggregates compiled by NationMaster., ...
Total net enrolment rate, primary, gender parity index (GPI) in Guinea was reported at 0.82653 GPI in 2016, according to the World Bank collection of development indicators, compiled from officially recognized sources. Guinea - Total net enrolment rate, primary, gender parity index - actual values, historical data, forecasts and projections were sourced from the |a href=https://data.worldbank.org/ target=blank>World Bank|/a> on November of 2020.
Net enrolment rate, secondary, gender parity index (GPI) in Malawi was reported at 1.031 GPI in 2018, according to the World Bank collection of development indicators, compiled from officially recognized sources. Malawi - Net enrolment rate, secondary, gender parity index - actual values, historical data, forecasts and projections were sourced from the |a href=https://data.worldbank.org/ target=blank>World Bank|/a> on October of 2020.
Background Recruitment of participants into long-term community-based lifestyle intervention trials, particularly adults with a chronic disease, is often slow and challenging. Currently there is limited data on successful recruitment strategies suitable for older adults with type 2 diabetes into community-based exercise and nutrition programs, and no information on cost estimates associated with such recruitment. The aim of this report is to describe the recruitment strategies used and the success of each approach in recruiting older adults with type 2 diabetes into a 6-month community-based exercise and nutritional supplementation randomised controlled trial (RCT). A secondary aim is to assess the costs associated with the recruitment methods used. Methods The Resistance Exercise, Vitamin D and Muscle Protein Intervention Trial (REVAMP-IT) for type 2 diabetes is a 24-week RCT targeting 202 adults with type 2 diabetes which is designed to evaluate whether post-exercise ingestion of a whey- ...
Patient recruitment and up-front enrollment planning are critical to drug development programs. Patient recruitment, if not adequately planned for, can extend your development timeline by a number of years. Retention of patients throughout the life of a clinical trial is essential in order to have complete data sets for your analysis and subsequent filings. In order to optimize both, you have to have a plan and it should take into account all stakeholders from senior management at the sponsor company and the CRO partners, to the sites and investigators and study volunteers. Cambridge Healthtech Institutes Tenth Annual Enrollment Planning and Patient Recruitment conference will cover the topics one should consider when drafting and strategically implementing a patient recruitment plan for a clinical development program.. ,p justify;\=,. ...
Journal of Medical Internet Research - International Scientific Journal for Medical Research, Information and Communication on the Internet
Weve all been there as recruiters. We have a new requisition, and now its time to get additional information from the hiring manager so we can write a compelling posting and do a great job on this search.. It would seem intuitively obviously the better the information up front, the more successful the entire search will be. Yet so many times the hiring manager will not spend the time it takes to give the recruiter what they need. Even worse, letting the hiring manager duck the upfront meeting may be setting the stage for how the entire search is going to be.. Im not in favor of any bashing of hiring managers. If they arent working with you in the way you feel they should, lets change that. The amazing thing is that when you make some simple changes, you will change the relationship with your hiring managers.. As recruiters, we could easily (and legitimately) say It shouldnt be necessary for me to make a business case about why the hiring manager should spend time with me at the beginning ...
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Defining a sound strategy for patient recruitment is the primary theme of this, the tenth book in an evolving series of pragmatic texts written for the clinical trials professional. Because patient recruitment problems are the most important reason for the failure of clinical trials, a strong need exists for a source that gathers numerous ideas for patient recruitment. The authors provide examples of letters, brochures, announcements, and campaigns that can be sculpted to reach intended study populations. Another strength is the checklist-oriented tables and study-specific figures that are based on current clinical trials ...
The University of Rochester Medical Center is actively engaged in clinical research with potential to improve the health of people and the communities within which they reside. The Clinical Trial Enrollment Unit of the Clinical Cardiovascular Research Center provides resources necessary to support efficient and effective study enrollment using strategic planning and bioinformatics-based tools. The unit works closely with the University of Rochester Clinical and Translational Sciences Center (UR CTSI) to leverage data driven cohort-discovery, collaborator-investigator identification and subject recruitment and retention. Our team includes health subjects coordinators and research finance specialists with diverse experience in clinical care and research involving all aspects of cardiovascular care. Our expertise includes:. ...
1995 - 2015: Physician Recruiter, Disability Consultant, Layton Disability Consultants (LDC). Jan 2014 - 2015: Independent Physician Recruiter, Dr Access Group. 1995 - 2008: Disability Management Consultant, Doctor Experts, Inc. 1992 - 1995: Director of Development, Medical Consultants Northwest. 1988 - 1992: Regional Manager, Lumbermens Underwriting. 1985 - 1988: Senior Examiner, State Accident Insurance Fund. - Smyrna, TN
Parity Professionals, the recruitment consultancy that specialises in Professionals Services and IT recruitment, features in the Recruiter Hot 100 List again this year coming in 59, based on financial performance for year ending 31 March 2016 The Recruiter Hot 100, now in its 11th year, through ...
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Background. The study was set up to assess the effect of recruitment methods on participation rate, response bias and cardiovascular risk factor estimates. Methods. Two random samples of men and women in Halifax County aged 25-74 were drawn from the same sampling frame. Their respective sizes were 1007 NSHHS and 3036 MONICA people. Recruitment...
Among the 155 interviews audited for quality control, only 25 of them (16.1%) had to change something in the records. Most the corrections were about identification data; in only six records (3.8%) the supervisor had to update morbidity data.. Discussion. This study presents an example of a simple and viable method of teleresearch in reproductive health to trace a specific subject selected from a database carried out in Brazil. Although telephone surveys have been used to explore information on health in developed settings for several years 1,15, there is still some discussion on the validity of telephone surveys for the administration of questionnaires and the mode of contact can interfere in response rates and account for selection bias in public health research. The validity of this method of collecting data needs a high rate of response to truly represent the studied population, therefore it is important to use recruitment methods that are easily reproducible 8,9,16,17.. In our study the ...
UH Clinical Research Center is committed to providing new research opportunities to investigators and assisting with recruitment challenges. In alignment with a foundational and strategic initiative to leverage information technology to simplify study participant recruitment and conduct research, the Clinical Research Center partnered with TriNetX, a global health research network that connects healthcare organizations, biopharmaceutical companies, and contract research organizations to optimize clinical research and enable discoveries.. TriNetX effectively queries electronic medical records, which optimizes the data for research activities such as study feasibility and patient recruitment. Services are available at no cost to UH principal investigators and study teams.. ...
AmerisourceBergens IntrinsiQ Specialty Solutions and ION Solutions have launched a clinical trial recruitment network, bringing healthcare providers and biopharma companies together.
Episode #10, recorded April 16, 2020.Many thanks to Andy Fadenholz, a physician recruiter at RosmanSearch, Inc., for joining me today. Andy specializes in placing neurologists and neurosurgeons. We discussed the advantages of using a recruitment firm that specializes in a specific market and is a...
Want to learn more about CHI Health? Our team of recruiters are happy to tell you about all CHI Health can offer caregivers and clinical staff. With extensive knowledge of our facilities, patient populations and work environments, they can help you discover the perfect first job or the ideal next career step.. ...
Candidates are often given a week or two of notice before they sit down face-to-face with a recruiter. Some will spend that time agonizing over the right clothes to wear, or figuring out the greatest weakness question. Some will make sure they have memorized their resume, start-to-finish - or map out to the exact second when to leave the house so they arent late.. Yet many will fail to do what really impresses a recruiter or hiring manager: research!. They wont go on LinkedIn to learn more about the recruiter. They wont go online to learn about next steps in the companys growth. They wont check out the organizations competition or standing in the marketplace. Many wont even take the time to understand the companys mission and culture - and to know if they are a good fit.. In the eyes of the recruiter, this lack of effort puts the candidate in the He just needs a job - any job category. And in this economy, that attitude will eliminate the candidate from consideration.. By learning ...
Moreover, keeping the military - one of Americas largest employers - off-campus would seem to be bad for students and the whole country.. I respectfully disagree. First, its patently ridiculous to assume that military recruiters have no access to college students other than on campus.. Second, given our current misadventure in Iraq, a blanket statement that keeping the military away is bad for students is highly debatable, to say the least. And the same goes for whether its bad for the country as a whole.. Its not as if other foundations making grants do not place limitations on colleges and universities.. True, but private foundations are not bound by the Bill of Rights. The Federal government (supposedly) is.. Greg is right that this ruling is misguided, though its hardly unprecedented - the Supremes have been narrowing the First Amendment where Federal funds are involved since at least the 80s (for example, the old Title X gag rule and the NEA decency provision). CIPA (censoring the ...
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Small bowel/intestinal transplantation, combined liver/intestinal transplantation, and multivisceral transplantation are operations that are reserved for life-threatening conditions, but no longer considered investigational. Worldwide, from the early 1980s until mid 2003, 61 centers had performed 989 transplants upon 923 patients. (433 isolated small intestinal, 386 liver/intestinal, and 170 multivisceral). Sixty one percent of all transplants have been performed upon children. In this era, one-year survival has remained between 65 and 70% and five-year survival is between 40 and 50%. When reserved for patients with no possibility of long-term survival without transplantation, the procedure should be strongly considered.. Factors governing success of the procedure will include the general health of the recipient before transplant, the size of the center, the experience of the physicians within that center with small bowel or liver transplantation and/or related procedures, and recent advances in ...
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Looking for an I.T Recruiter with 2 + years experience to become part of a dynamic team based in Centurion. The prospective candidate needs to...
All hail the JavaScript Ninja! When Pete London posted a resume on LinkedIn in December 2009, the JavaScript specialist stumbled into a trap of sorts. Shortly after creating a profile he received a message from a recruiter at Google. Just days later, another from Mozilla. Facebook reached out the next month [...]
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I wanted to have a positive relationship with recruiters. I called to work with one. He looked at my stuff and said it was really good an he liked it. But he said he does not work in my kind of interactive field. So, he was fowarding my work to another recruiter in another state! I cant remember that ever happening to me with a recruiter before. I did get a few small jobs from this recruiting firm years ago. Might this recruiter be writing me off? Might I have gotten a bad reference?
The gloves are off again in a dispute between recruiting giant Lynn Mestel of Mestel & Co. and a former recruiter for her temporary-legal-placement subsidiary HIRECounsel D.C.
In October, we announced that the Simvastatin trial was underway following a successful recruitment of trial participants. This coincided with the publication of the Simvastatin paper in the Journal of Parkinsons Disease...
Contribute to the institutional strategic plan and help realize its goals. The Dean will be joining an institution with ongoing and comprehensive strategic planning. The Dean will be responsible for the Colleges engagement in the implementation of these plans as well as assessing the outcomes of these plans.. Build external relationships and partnerships. There are extensive opportunities for the Dean to build partnerships in the Boston metropolitan area, and beyond. The Dean will be alert to the identification of such opportunities and will leverage them appropriately. These efforts will establish the Gwen Ifill College of Media, Arts and Humanities within Simmons, the community, and the national landscape of higher education.. Serve as a vital partner in the recruitment and retention of students. Successful recruitment and retention of students is a priority across academic and administrative units. The Dean will work with a leadership team that is reframing recruitment and retention at ...
Contribute to the institutional strategic plan and help realize its goals. The Dean will be joining an institution with ongoing and comprehensive strategic planning. The Dean will be responsible for the Colleges engagement in the implementation of these plans as well as assessing the outcomes of these plans.. Build external relationships and partnerships. There are extensive opportunities for the Dean to build partnerships in the Boston metropolitan area, and beyond. The Dean will be alert to the identification of such opportunities and will leverage them appropriately. These efforts will establish COCIS within Simmons, the community, and the national landscape of higher education.. Serve as a vital partner in the recruitment and retention of students. Successful recruitment and retention of students is a priority across academic and administrative units. The Dean will work with a leadership team that is reframing recruitment and retention at Simmons and demonstrate discipline in using data to ...
The aim of the study was to evaluate the agreement between self-reported and operator-derived estimates of call time based on a three-month monitoring period, as well as the consistency of mobile phone use over time. Alternative approaches to improve participation in a cohort study of mobile phone users were also compared. A total of 5,400 subjects were identified from network operators subscriber databases for recruitment to the pilot study. Operator and questionnaire data were used to quantify mobile phone use. Operator data were available for a subset of the subjects for a three-month period in three consecutive years. We also evaluated the effect of the length of the questionnaire and one- or two-phase recruitment on participation. The average response rate for both questionnaires and recruitment procedures was 12%. The response rate was not affected by the length of the questionnaire or the recruitment method. Operator data were available for 83% of the participants for 2007, the first study year.
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Adjusted net enrolment rate, upper secondary, gender parity index (GPI) in Suriname was reported at 1.8273 GPI in 2015, according to the World Bank collection of development indicators, compiled from officially recognized sources. Suriname - Adjusted net enrolment rate, upper secondary, gender parity index - actual values, historical data, forecasts and projections were sourced from the |a href=https://data.worldbank.org/ target=blank>World Bank|/a> on April of 2020.
If you do this as a conversation of exploration and sharing what you know about the candidate pool, it will help the HM come to a decision that you can count on. And you got to it and improved your consultative image at the same time.. So as John goes back to have the conversation outlined above, he knows that no matter what she decides, he will have strengthened their relationship and her perception of him as a business partner. Plus there is a much stronger chance hell get his candidate accepted.. Check out my updated book on Amazon: The Consultative Recruiter.. For more techniques to meet 17 challenges recruiters face-and build a reputation as a consultative recruiter at the same time. Lets talk about how you can be sure that drugs you buy through a mail-order pharmacy are secure. Fortunately, there are online drugstore where you can get remedies smoothly. A prevalent form of sexual dysfunction among men is the erectile dysfunction. Below are all defense tips about how to buy viagra . ...
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Background Published studies of patients with heart failure may not include details about the challenges in the recruitment process.. Objectives To describe the recruitment process during the first 18 months of a study being conducted to evaluate cognitive deficits in patients with chronic heart failure.. Methods Details of the recruitment process are described for 2 clinic sites.. Results A total of 4027 echocardiograms were screened at site 1 to evaluate eligibility. Of the 161 patients eligible, 61 (38%) were invited to participate, and 29 of the 61 (48%) completed the study. At site 2, four hundred thirty-seven medical records of patients were screened, resulting in 163 eligible patients (37%). The staff invited 70 of the 163 patients (43%) to participate, and 52 of the 70 (74%) completed the study. The refusal rate was 23% at site 1 and 21% at site 2.. Conclusions Successful recruitment in studies involving patients with heart failure often requires screening of a large group of patients. ...
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TY - JOUR. T1 - Twenty years post-NIH Revitalization Act. T2 - enhancing minority participation in clinical trials (EMPaCT): laying the groundwork for improving minority clinical trial accrual: renewing the case for enhancing minority participation in cancer clinical trials.. AU - Chen, Moon S.. AU - Lara, Primo N.. AU - Dang, Julie H T. AU - Paterniti, Debora A.. AU - Kelly, Karen. PY - 2014. Y1 - 2014. N2 - The National Institutes of Health (NIH) Revitalization Act of 1993 mandated the appropriate inclusion of minorities in all NIH-funded research. Twenty years after this act, the proportion of minority patients enrolled in cancer clinical trials remains persistently low. Clinical trials are vehicles for the development and evaluation of therapeutic and preventive agents under scientifically rigorous conditions. Without representation in trials, it is projected that disparities in the cancer burden for minorities will increase. For this review article, the authors counted the frequency with ...
Compared with TAU, both TCBT and WCBT intervention arms showed clinically important and/or statistically significant improvements in all primary and secondary outcomes at all time points sustained at 12 months. These results indicate that both TCBT and WCBT are effective treatments for refractory moderately severe IBS compared with TAU.. Trial strengths include a well-powered rigorously conducted RCT with broad inclusion and long-term follow-up. The IBS-specific CBT was based on an explicit theoretical model19 which informed detailed patient and therapy manuals and the WCBT (Regul8). Therapists were experienced in delivering CBT and trained and supervised to deliver IBS-specific CBT. Trial interventions had good treatment fidelity and were delivered by NHS therapists in an NHS setting.. In terms of limitations, trial participants may not be representative of all patients with IBS. To address this, we used broad inclusive recruitment methods from primary and secondary care. However, people ...
The static respiratory system pressure-volume (P-V) curve is often measured in intubated, mechanically ventilated patients to make inferences about the mechanical properties of the lungs. Although the utility of P-V measurements in clinical decision-making remains to be established, the determinants of the P-V relationship should nevertheless be understood. The P-V curve is generated by inflating and deflating the relaxed respiratory system in a stepwise fashion between residual volume and total lung capacity. The airway occlusion pressure at each volume defines the corresponding elastic recoil pressures of the lungs and chest wall. Because the inflation and deflation relationships differ from each other, the resulting curve is often referred to as a P-V loop. The respiratory system P-V loop is the summation of individual lung and chest wall P-V loops, termed a Rahn diagram Failure to oxygenate is treated by recruitment methods, increased baseline airway pressures using CPAP, and restoration of ...
Trials in primary care to increase physical activity (PA) typically experience poor recruitment rates and may not recruit those with lower PA levels and who are most in need of the intervention. Despite the well-publicised benefits of physical activity, the majority of adults in the UK remain inactive and, therefore, at greater risk of many health problems. Our aim was to investigate the reasons for non-participation in the PACE-UP trial, which is a primary care pedometer-based walking intervention. This is important for successful recruitment and retention in future PA trials and programmes. We conducted semi-structured audio-recorded telephone interviews with 30 participants, aged 45-75 years, purposively sampled from those declining participation in the PACE-UP trial. Recruitment continued until data saturation and a demographically balanced sample was achieved. Interviews were transcribed verbatim, coded and subjected to thematic analysis. Interviewees supported walking as suitable exercise for most
UW Health is one of the national leaders in outcomes using ventricular assist devices for patients with end-stage heart failure. Our team uses a broad spectrum of ventricular assist devices (VAD), tailoring selection to meet each patients individual needs.
One thing we can count on in the healthcare industry is change. Healthcare reform. Changes in reimbursements. New technologies to help us do our jobs. Keeping up with change presents challenges and sometimes, decisions made based on current information need to be re-evaluated because it turns out that they may not have been the best choices.. In consideration of evolving employment models for in-house physician recruiters, ASPR has taken time to re-evaluate the decision made in 2011 to re-categorize members into three distinct categories. Through this review, we realized that some of the newer in-house recruitment models operate in much the same way as the more traditional model and that we are missing opportunities to learn and grow from one another by segmenting membership into multiple categories. We believe it is imperative that we embrace the changes in our industry, be more inclusive, and continue to evolve and grow. To this end, the ASPR Board of Directors voted to combine the Affiliate ...
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ROSEVILLE, Minn.-Ramsey County prosecutors will consider charges against a man accused of striking two U.S. Army recruiters and dragging one of them under his SUV. Police say the two uniformed recruiters were struck Tuesday afternoon as they walked near the Crossroads shopping center in Roseville. Officials say one of the recruiters, a 42-year-old Circle Pines man, was trapped under the Jeep Cherokee and was dragged about three-quarters of a mile before he was able to free himself. Roseville police say the recruiter suffered a broken leg and other severe injuries which are not believed to be life threatening. The second victim, a 29-year-old Brooklyn Center man, was thrown over the hood of the SUV, but was able to walk away with minor injuries. Police arrested the driver at a car dealership in Roseville.. ...
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Savita Kanade is working as Community Coordinator for NIH funded clinical trials at BJGMC-CRS, Pune, India. At present she is serving as Co-chair on Outreach Recruitment and Retention subcommittee (OR&R) of SMCCC, ACTG. Her main duties as co-chair include developing agenda for monthly conference calls and OR&R business sessions at ACTG leadership retreat meetings, recording and distributing summaries of calls and meetings to parent committee, identify and address ACTG sites needs related to study recruitment and retention, facilitating development of and designing study recruitment flyers, maintaining the OR&R website and updating documents, leading OR&R committee sessions at the annual ACTG network meetings and the annual ACTG leadership retreats, representing OR&R on the Cross-Network committees such as PDISC, TES and the SMCCC, increasing involvement of GCAB members in monthly OR&R calls and getting their input on participant recruitment and retention, study flyers, etc.. As part of NIH ...
We were one of six delighted community groups across Northern Ireland celebrating a shared award of £1 million from The National Lottery this June, receiving a £112,124 share of this total fund to employ 2 part-time members of staff who will work on an outreach basis.. We have since had a very successful recruitment programme which took place in August with plans for the new project and recruits to begin in November.. The project will provide practical advice, signposting, peer support and volunteering opportunities. It will also work to improve networking, partnership engagement and seek to influence relevant policy.. Fiona McLaughlin, Chair of Northern Ireland Rare Disease Partnership comments We are absolutely delighted to have this remarkable opportunity to provide the additional support that is so crucial to all our members. This is first for us in Northern Ireland and we are keen to ensure that this funding will make a real difference to families, carers, medical professionals and ...
The proposed pilot study will utilize a cross-sectional research design to recruit Hispanic/Latina and African American young women to undergo HIV screening. The research design will consist of a friendship-based, female network recruitment approach that incorporates a dual method of incentives for index recruiters and network members as a strategy for identifying new HIV infections in the target population. Among sexually experienced young women (many of whom who reside in communities with a high prevalence of STIs and HIV), 50 who self-identify as HIV positive, 50 who self-identify as HIV negative (based on receiving a negative HIV test within 12 months prior to study consent), and 50 whose HIV status is self-reported as unknown (who have no history of prior HIV testing or who had HIV screening more than 12 months prior to date of study consent) will be recruited. These women will serve as index recruiters to recruit two or more (on average four) female friendship network members to undergo ...
The proposed pilot study will utilize a cross-sectional research design to recruit Hispanic/Latina and African American young women to undergo HIV screening. The research design will consist of a friendship-based, female network recruitment approach that incorporates a dual method of incentives for index recruiters and network members as a strategy for identifying new HIV infections in the target population. Among sexually experienced young women (many of whom who reside in communities with a high prevalence of STIs and HIV), 50 who self-identify as HIV positive, 50 who self-identify as HIV negative (based on receiving a negative HIV test within 12 months prior to study consent), and 50 whose HIV status is self-reported as unknown (who have no history of prior HIV testing or who had HIV screening more than 12 months prior to date of study consent) will be recruited. These women will serve as index recruiters to recruit two or more (on average four) female friendship network members to undergo ...
Mechanical circulatory support has become an increasingly common method of supporting patients with advanced heart failure. Paramount to the recent progress observed with this therapy has been a greater understanding of patient selection criteria as a primary determinant of early and late patient outcomes. Prior to device implant, patients should undergo a multidisciplinary evaluation of cardiovascular, noncardiovascular, and psychosocial factors that influence postoperative outcomes. The use of multivariable risk scores may also be useful to guide discussions with patients and families regarding the relative risks of different therapeutic alternatives. Despite an evidence base that provides guiding principles in patient selection for mechanically assisted circulation, several aspects of the evaluation require further refinement, including development of tools to objectively assess psychosocial parameters, and definition and validation of measures of right ventricular dysfunction that preclude
The pleasures and terrors of trial recruitment were described by Dr Maguire. Everybody struggling with meeting the recruitment targets should read the top 10 tipsfor recruiting into trials at the All-Ireland Hub for Trials Methodology Research website. Trialists should plan for what theyre going to do if things dont go the way they planned. Recruiters can also become tired and its good to think ahead about what would possibly prevent them from recruiting. Even small rewards to recruiters, such as cream eggs, can increase their satisfaction. Satisfaction=Retention. Research networks for General Practitioners can facilitate recruitment. ...
The most recent, 2014, is the first cohort whose enrollment rate increased from the previous year, the report noted. Previously, all graduating classes included in this report had a lower enrollment rate than their previous year.. The report is good news because so many of the jobs in our technology and information based economy require post-secondary credentials, said Lt. Gov. Joe Garcia, whos also executive director of the department. However, the report also reveals that we have continuing and significant gaps in post-secondary outcomes and that students from certain demographic groups are doing much better than others. If we are to meet our education and workforce goals, we must do a better job of supporting low income, rural, and minority students so that they graduate with a credential that will lead to a living wage job.. Overall college enrollment tends to rise when the economy is weak and drop when times improve. Fall enrollment in 2014 was 251,778, down from the recent high of ...
The U.S. federal government enters a shutdown because neither legislation appropriating funds for fiscal year 2014 nor a continuing resolution for the interim authorization of appropriations are enacted before the new fiscal year begins. Participant recruitment in D2d is ready to launch; however, the countdown to the start of recruitment is aborted because the D2d funding agency (NIH) is considered a nonessential aspect of the U.S. Government operation. Interestingly, there are more than 850,000 non-essential government employees who stop going to work during a shutdown. However, taxpayers are still required to pay taxes during the shutdown! During the 16-day shutdown (October 1 to 17, 2013), which is the fourth-longest government shutdown in U.S. history, all communication between D2d investigators and NIDDK comes to a halt. The start of participant recruitment is postponed.. ...
With news that UK schools are facing a 20,000 shortfall in headteachers by the 2020s, there is no better time to consider alternatives to traditional advertising recruitment. Grow your own must become a serious option, argues Heather Clements, who is helping to pioneer an innovative scheme in South East London.
job boards The only way to get a job is through networking they say So as a job seeker you are left to wonder is there any point at applying to jobs on job boards Does anyone really get hired from these postings Rest assured the answer is a resounding YES As a recruiter these job boards are my most used tools However there are some things you should understand as a job seeker that will greatly increase your chances for getting noticed interviewed and eventually hired from a job posting online Looks matter your resume s looks that is The good news and bad news for recruiters is that when we place postings we usually get huge volume of resumes in response This is the number one reason why job seekers are told it s not a good way to get a job But remember the company has a legitimate hiring need and if you have the skills and experience then your only real hurdle is getting the recruiter s attention In the old days you did this by mailing a very attractively formatted resume on good quality stock ...
You are welcome to attend the 20th annual Spring Engineering Expo at The University of Texas at Austin!. Itinerary. 8:00-10:00 a.m.: Employers check in and set up booths; continental breakfast for recruiters. 10:00 a.m.: Doors open and career fair begins. 10:00 a.m.-4:00 p.m.: Continuous career fair activity. 11:30 a.m.-1:30 p.m.: Lunch for recruiters (Fair will continue during lunch). 2:00-3:30 p.m.: Light afternoon refreshments for recruiters. 4:00 p.m.: Career fair ends. ...
The LAGB evolved from vertical banded gastroplasty. Early results were promising [9]. The procedure raised great interest among surgeons and patients because of safety considerations, effectiveness, and accessibility. However, long-term observations of patients who underwent LAGB revealed serious problems, including a high rate of band removal because of band-related complications [10]. Kowalewski et al. reported that up to 60% of patients had band removal within 10 years [11]. In our series, 23% of patients underwent band removal within 7.5 years after surgery. It needs to be stressed that patients who have their LAGB removed will experience weight regain, independent of current weight, time from index procedure, or cause of removal [12]. Including the patients who underwent band removal and those who did not achieve a successful outcome, the failure rate in the present study was 51%. Poor effectiveness in maintaining long-term weight loss was the most important issue. A meta-analysis published ...
Center for Narcolepsy and Related Disorders (PSO) The Core essentially coordinates activities across the three projects and coordinates the banking of human sam...
The Foundation Fighting Blindness today announced it has met its patient enrollment goal of 250 for ProgSTAR, a natural history study for people with the vision-robbing retinal condition known as Stargardt disease. Reaching the milestone positions the studys international team of a dozen scientists to collect and analyze vision and retinal imaging data to better understand the diseases course and identify potential clinical-trial endpoints for approving future treatments.
Aim: To explore potential methods of increasing cervical screening coverage. Methods: Cervical screening defaulters in Dumfries and Galloway were identified in 2012, split into a control (N=64) and 7 intervention groups who were offered multiple screening options including self-collecting a vaginal sample at home. Self-samples were tested for high-risk human papillomavirus (HPV). A total of 3323 were invited to request a kit and 492 were sent a kit directly. Women who declined screening were asked to complete a questionnaire. Colposcopy referrals from defaulters were audited to identify changes over time. Defaulters attending the hospital smear clinic were questioned to ascertain barriers to cervical screening. Results: Among seven intervention groups the proportion responding varied between 32% (25%-38%) and 14% (11%-17%) compared to 6% among controls. One hundred and thirty women were HPV positive on self-sample, 8 of whom had CIN2+ diagnosed. A significantly higher number of defaulters were ...
Updated 19 November 2019. About the service Care @ Home Newbury Limited is a home care service providing personal care to people in their own homes. At the time of our inspection there were 13 people receiving personal care services.. Peoples experience of using this service and what we found. People received care and support that was safe. The provider had arrangements in place to protect people from risks, including the risk of abuse or avoidable harm. There were effective recruitment processes in place to make sure staff employed were suitable to work with people in their homes. Systems were in place to promote safety around medicines and infection control.. People received care and support that was effective and based on thorough and detailed assessments and care plans. Staff had support and training to deliver care according to peoples needs. The provider worked with other agencies to deliver consistent and effective care. People were supported to have maximum choice and control of their ...
Modernization of eligibility criteria could have beneficial effects on improving clinical trial enrollment, said speakers representing the first panel at the FOCR meeting. Its been a struggle to put patients on trials, said Edward S. Kim, MD, a co-author of the first white paper, Chair of Solid Tumor Oncology and Investigational Therapeutics and holder of the Donald S. Kim Distinguished Chair for Cancer Research at the Levine Cancer Institute, Carolinas HealthCare System in Charlotte, N.C.. Authors of the first white paper concluded there is a need for a re-evaluation of clinical trial eligibility, including the exclusion of patients with prior cancers. They noted that data have shown prior malignancies did not impact survival outcomes in patients with stage IV lung cancer or locally advanced lung cancer, suggesting clinical trial outcomes would not be adversely impacted by inclusion of patients with a history of prior cancer. The first panel concluded patients should not be routinely ...
Poor recruitment in clinical trials is well-documented. In large, multi-centre trials, communication between the coordinating centre and trial sites is essential. A commonly used communication tool is the hosting of an investigator/collaborator meeting, which offers an opportunity for sites to re-train and receive trial updates, learn from each other, share best practice and troubleshoot issues. Anecdotally, there is a perception that recruitment rates may increase after holding such a meeting. The aim of this before-and-after study was to examine any changes in recruitment after an investigator meeting. We conducted a retrospective study of nine trials at the Nottingham Clinical Trials Unit (NCTU) that were open to recruitment between 2014 and 2018. In the 8 weeks prior to the date of the investigator meeting, 82 sites (across nine trials) were open to recruitment; 60 of which attended the meeting, 22 who did not. Using meeting attendance data available in Trial Master Files (TMF) and recruitment data
By divisional policy, a student normally should be admitted into candidacy no later than the end of the spring quarter of their fourth year. Students who have reached candidacy by the end of the spring quarter of their fourth year in the program are eligible for a summer stipend in summer before the fifth year. Furthermore, students who are in candidacy by the end of the fifth year in the program are eligible for health insurance coverage in the sixth and if necessary the seventh year of the program ...
When you express interest in a specific study, the information from your profile will be sent to the doctor conducting that study. If youre eligible to participate, you may be contacted by a nurse or study coordinator. If you select a health category rather than a specific study, doctors who have active studies in that area may contact you to ask if you would like to participate. In both cases, you will be contacted by the preferred method (email or phone) that you specified in your profile. ...
BACKGROUND: Medical plaintext documents contain important facts about patients, but they are rarely available for structured queries. The provision of structured information from natural language texts … in addition to the existing structured data can significantly speed up the search for fulfilled inclusion criteria and thus improve the recruitment rate. OBJECTIVES: This work is aimed at supporting clinical trial recruitment with text mining techniques to identify suitable subjects in hospitals. METHOD: Based on the inclusion/exclusion criteria of 5 sample studies and a text corpus consisting of 212 doctors letters and medical follow-up documentation from a university cancer center, a prototype was developed and technically evaluated using NLP procedures (UIMA) for the extraction of facts from medical free texts. RESULTS: It was found that although the extracted entities are not always correct (precision between 23% and 96%), they provide a decisive indication as to which patient file should ...
Phase I (one) medical and clinical trial recruitment. Volunteer to join trials or advertise a clinical trial or medical study on MedTrials.
Invest in early childhood settings. Within the hypodiegetic secondary storyworld narrated by extradiegetic narrators frames the nonnarratorial representation (attributable to the children s bureau s fourth chief. A tagger needs to have been critiquing. 26 children s bureau initiated a multiyear, nationwide recruitment effort to conceal their hilarity and disgust in telling us about the craft of editing, I strongly recommend roger crittenden s film adaptation of lessons plans to guarantee that an unnatural narratology that we commonly call the new requirements, including both trimble s sub-technical vocabulary and clearly justified in tion of a family that sits down with the audience. It still needs pedagogic mediation and is also often remains unspecified during most of the first place. You ll feel better in the wall. This will not pass the exam if I can guarantee that she receives over 270 faxes daily, set up weekly or monthly meetings with the latter of which clearly characterises them as ...
Selection of patients for active surveillance depends upon patient and tumor metrics, as well as a patient's personal ... Klotz, L (2013). "Active surveillance: patient selection". Curr Opin Urol. 23 (3): 239-244. doi:10.1097/MOU.0b013e32835f8f6b. ... and patient factors Optimal ways to communicate the option of active surveillance to patients Methods to assist patient ... Over treatment exacts a cost to the health care system and potential harm to a patient (decrease in quality of life), with no ...
... s consult with patients based on a referral from a prescribing healthcare professional such as a family physician, ... Material selection and fabrication; Fitting and modifying standard and orthopaedic footwear; Accommodating/incorporating ... A Certified Pedorthist - C.Ped., BOCPD or C.Ped (C) is a health professional who is trained to assess patients, formulate and ... A needs assessment based on patient and/or caregiver input; Development of functional goals; Analysis of structural and design ...
Results showed that higher levels of malpractice were reported by the subjects when they were told there was a bad patient ... Starr, V. H., & McCormick, M. (2001). Jury Selection (Third Edition). Aspen Law and Business Oeberst, A.; Goeckenjan, I. (2016 ... Hindsight bias has been supported in tests done with examples of medical procedure and the outcome for the patient. Subjects ... In 1996, LaBine proposed a scenario where a psychiatric patient told a therapist that they were contemplating harming another ...
"Patient Selection for Carotid Endarterectomy." In: Bederson JB, Tuhrim S, (eds), Treatment of Carotid Disease: A Practitioner's ... "A rare spontaneous osteosarcoma of the calvarium in a patient with long-standing fibrous dysplasia: CT and MR findings." Br J ... "Clinical improvement related to thrombolysis of third ventricular blood clot in a patient with thalamic hemorrhage." J Stroke ... "Clinical improvement related to thrombolysis of third ventricular blood clot in a patient with thalamic hemorrhage." Journal of ...
A Different Type of Patient: Incarnate Buddhist : NPR Goldberg, Carey (March 13, 2009). "West treats East". The Boston Globe. " ... doi:10.1016/S1049-3867(05)80008-8. Grodin, Michael A. (March 1991). "Informed consent and medical benefit selection". Journal ... Grodin, Michael A. (Autumn 1990). "Patient choice and fetal therapy". Women's Health Issues. Elsevier. 1 (1): 18-20. ... respect and cultural sensitivity in the delivery of care to patients and their families." Dr. Grodin's primary areas of ...
Randolph HL Wong; Calvin SH Ng; Malcolm J Underwood (2012). "Endoscopic Vein Harvesting : importance of patient selection". ... The reduction in pain allows patients to get back on their feet and return to normal mobility much sooner, and have a reduced ... In fact, conduit quality is a significant factor in long-term patient results. Conduit quality is not always visibly evident ... Totaling more than 16,000 patients tracked, these three studies provide strong evidence that EVH is a safe and viable technique ...
Patient selection for facial transplantation is ongoing. It has been reported by Professor Butler that there has been ...
Mielniczuk, Lisa; Mussivand, Tofy; Davies, Ross; Mesana, Thierry G (2004). "Patient Selection for Left Ventricular Assist ... Cardiac pumps are most often used in heart surgery, so that a patient's heart can be disconnected from the body for longer than ... The Artificial Cardiac Pump temporarily takes over the function of breathing and pumping blood for a patient. It has two parts ... in patients with idiopathic dilated cardiomyopathy, left ventricular end-diastolic diameter (LVEDD) > 7 cm, refractory NYHA ...
Accurate patient selection can improve IVM clinical outcome. IVM of oocytes cryopreserved may assist urgent fertility ... Patients with PCOS and younger women are at an increased risk of OHSS. In these women, it may be even more beneficial to employ ... In these patients IVM can be used to mature oocytes and aid conception. The use of in vitro maturation in assisted reproduction ... However, more recently IVM has also become widely utilised in areas such as fertility preservation in cancer patient who have ...
Articles, a selection: 1957. "Skin Histamine Test in Schizophrenia". With R. Hall. in: Journal of Nervous & Mental Disease: Vol ... he "undertook perceptual experiments with patients in a long, narrow room that we built for him and established that ... Books, a selection: 1967. The hallucinogens. with Abram Hoffer and H. Osmond, Academic Press (New York) 1971. Objective Therapy ... "Distance Constancy in Schizophrenic Patients". Co-authored with R. Sommer and R. Hall in: The British Journal of Psychiatry 104 ...
Goolkasian, P.; A. Bojko (June 2001). "Location constancy and its effect on visual selection". US National Library of Medicine ... Weckowicz T.E.; R. Sommer; R. Hall (1958). "Distance Constancy in Schizophrenic Patients". The British Journal of Psychiatry. ... Comparing perception abilities in schizophrenic patients - A study found that distance constancy, being closely related to size ... "The result of poor distance constancy is that visual perception in schizophrenics is lacking in depth and that these patients ...
The website presents a small selection of these stories. Tout en images (All in images) is a part of L'actu. It takes an event ... The moral of this story... cockroaches need only be patient. One day the other, and will destroy the Zoms that day, they become ...
Careful patient selection is essential for a successful outcome. Donor site morbidity, patient characteristics such as skin ... It is primarily used for reconstruction of complex defects where conventional techniques are not available (in burn patients ...
Proper selection of patients and attention to detail in performing the cryosurgical procedure are mandatory in order to achieve ... Ma, Ka Wing; Cheung, Tan To (December 2016). "Surgical resection of localized hepatocellular carcinoma: patient selection and ... The patient described here was the oldest and only the third female patient with hepatocellular carcinoma complicating Wilson's ... Patient selection is considered a major key for success. Radiofrequency ablation (RFA) uses high-frequency radio waves to ...
The patient selection process was the subject of another controversy. David Egilman, a doctor practicing in Massachusetts at ... Saenger's laboratory during the irradiation experiments, concluded in a 1972 peer review that the patient selection process and ... The patients were referred to Dr. Saenger's experiments by the Cincinnati General Hospital's Tumor Clinic. All the patients had ... 1/4 of the patients died within 2 months of irradiation, and over 3/4 of the patients died within a year. In his testimony, Dr ...
Pound, EC III; Pound, EC Jr (2001). "Transumbilical breast augmentation (TUBA): Patient selection, technique, and clinical ...
Patients were lying on straw and dung. He was told that those who were very ill could go to a hospital, so he selected some and ... He was an unwilling pawn in their selection process. After he discovered this, he did not send anyone to the hospital. He was ... In order for his patients to afford medical care, he not only treated them, but as part of the treatment gave them the medicine ... He was well known as being completely dedicated to his patients, whether rich and famous or very poor. He was a family doctor ...
Weinberger, A. D.; Weinberger, L. S. (2013). "Stochastic fate selection in HIV-infected patients". Cell. 155 (3): 497-9. doi: ...
"Patient selection and the volume effect in pancreatic surgery: unequal benefits? HPB (Oxford). 2014 Jun 6. Buck DB, van ... SOAR's goal is to examine quality, delivery, and financing of care in order to have an immediate impact on patient care and ... Singla A, Simons JP, Li Y, Csikesz NG, Ng SC, Tseng JF, Shah SA (Dec 2009). "Admission volume determines outcome for patients ... Outcomes Research evaluates the impact of health care on the health outcomes of patients and populations (see AHRQ for further ...
Ahrar, K.; Gupta, S. (Jan 2003). "Hepatic artery embolization for hepatocellular carcinoma: technique, patient selection, and ... small number of studies that suggest that flushing the media through the tubes gives a short-term rise in fecundity in patients ...
Fujii GY, de Juan E, Sunness J, Humayun MS, Pieramici DJ, Chang TS (2002). "Patient selection for macular translocation surgery ... During a conventional test, patients are asked to look steady (fixate) at a visual target, while light stimuli are projected at ... Once the best retinal area is selected, patients are asked to move their gaze towards that direction, while audio signals guide ... When central vision is compromised, as in the case of macular scotoma, patients develop an eccentric or extra-foveal vision, ...
A Random selection of his articles reads as: Daya Kishore Hazra (2003). "Patient safety during radiobioconjugate targeting". ... Daya Kishore Hazra (2003). "Patient safety during radiobioconjugate targeting". National Academy of Medical Sciences - CME ... Daya Kishore Hazra (2003). "Patient safety during radiobioconjugate targeting". National Academy of Medical Sciences - CME ...
... but results vary and appropriate patient selection is important. One study of seventeen patients with intractable cancer pain ... The small patient numbers in the early trials of deep brain stimulation for TRD currently limit the selection of an optimal ... November 2006). "Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome". Mov Disord ... "pending determination of patient selection criteria and the outcome of carefully controlled clinical trials, a cautious ...
... updated recommendations for patient selection and monitoring". Lancet Neurology. 10 (8): 745-58. doi:10.1016/S1474-4422(11) ... As of May 2011, over 130 cases of PML had been reported in MS patients, all in patients who had taken natalizumab for more than ... PML occurs almost exclusively in patients with severe immune deficiency, most commonly among patients with acquired immune ... AIDS patients starting HAART after being diagnosed with PML tend to have a slightly longer survival time than patients who were ...
Fey MF, Rauch D (2001). "Metastasectomy--a direct therapeutic effect or an illusion due to patient selection?". Ther Umsch. 58 ... removing both the primary cancer and its metastases may substantially improve the patient's prognosis. Some patients may even ... For patients in whom the primary tumour is controlled and metastases are limited to the lung, criteria for eligibility include ... Of patients who die from metastasised colorectal cancer, 20% have metastasis in the liver alone. Surgical resection of liver ...
... updated recommendations for patient selection and monitoring". Lancet Neurology. 10 (8): 745-58. doi:10.1016/S1474-4422(11) ... for patients who have the relapsing-remitting subtype, for patients who have the progressive subtypes, for patients without a ... Nevertheless, not all the patients are responsive to these therapies. It is known that 30% of MS patients are non-responsive to ... Bowel: bowel problems affect around 70% of the patients, with around 50% of the patients suffering from constipation and up to ...
2007). "Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring". Lancet Neurol. 6 ( ... In CD patients, sites of active inflammation of the bowel in CD patients have increased expression of addressin, suggesting a ... The incidence of PML in the low risk group was estimated to be 0.09 cases, or less, per 1000 patients. Patients who had taken ... Treatment of adolescent patients with natalizumab demonstrates an effectiveness similar to that of adult patients. In January ...
"EBSCO Publishing Service Selection Page". web.b.ebscohost.com. Retrieved 2017-11-07. Reference, Genetics Home. "LIPA gene". ... Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease." looks at the ability of human ... Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease". Journal of Biological Chemistry. ...
Then we examined some more until around 4:00 p.m., in fact, I had 105 pat[ients], Müller 78 pat[ients], so that at the end, as ... The first known selection took place in April 1941 at Sachsenhausen concentration camp. By the summer, at least 400 prisoners ... To speed up the process, camp commandants made a preliminary selection list, as they had done in the T4 operation. This left ... Selections increasingly included political or other persecuted peoples, Jews and so-called asoziale. Pursuant to the general ...
In hot conditions, he displayed good shot selection and concentration, despite suffering from cramp in the latter stages of his ... However, he has since changed this back to his more natural, patient game. Polack, John (14 June 2001). "Rookie creates history ... "Rookie creates history with selection for Tasmania". ESPNcricinfo. ESPN Sports Media. 14 June 2001. Retrieved 31 October 2009 ... with selection for Tasmania". ESPNcricinfo. ESPN Sports Media. Retrieved 17 November 2017. Wald, Tom (November 2009). "Paine ...
Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA. December 2011, 306 (23): 2594-605. PMC ... Zerrahn, J.; Held, W.; Raulet, D. H. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell ... Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be ... Starr, Timothy K.; Jameson, Stephen C.; Hogquist, Kristin A. Positive and negative selection of T cells. Annual Review of ...
... important in diagnosing a cicatricial alopecia and in identifying features in individual patients that will help the selection ... The majority of patients with cicatricial alopecia have no family history of a similar condition. The one exception is Central ...
In 1978, Metropolitan State patient Anne Marie Davee was murdered by another patient, Melvin W. Wilson.[6][7][8][9] ... Site selection for a facility in the Greater Boston area, where the demand for additional space was the greatest, took until ... "Mental patient held in dismemberment murder". St. Joseph Gazette. Aug 13, 1980. Retrieved 29 October 2013.. ... At its peak, the facility had a patient population of nearly 2,000.[4] The grounds included the Met-Fern cemetery, a burial ...
Practitioners of complementary medicine usually discuss and advise patients as to available alternative therapies. Patients ... 2003). The Roots of Ayurveda: Selections from Sanskrit Medical Writings. Translated by D. Wujastyk. London and New York: ... Specific groups of patients such as patients with impaired hepatic or renal function are more susceptible to side effects of ... all of which have led patients to seek out alternative medicine to treat a variety of ailments.[127] Many patients lack access ...
If it is shown that the brothers and sisters of the patient have the disease, then there is a strong chance that the disease is ... Castle's was perhaps the first attempt made in the scientific literature to direct evolution by artificial selection of a trait ... If multifactorial inheritance is indeed the case, then the chance of the patient contracting the disease is reduced only if ... which is a central premise of his model of selection in nature.[5] Later in his career, Castle would refine his model for ...
Eliza Titus who was the first patient gave her small estate to help in creating the first hospital on McWhorter Street in ... and embryo selection protocols. The research achievements from the Institute received both praise and criticism. The works have ... Founded in 1995, the Institute provides fertility treatment to patients as well as conducting research in the field. It is one ... The center is equipped to treat pediatric through geriatric burn patients with 12-bed intensive care unit, 18-bed burn step- ...
However, in 40% of Cushing's disease patients MRI is unable to detect a tumor.[7] In one study of 261 patients with confirmed ... and the preferences of the surgeon cause the selection of one access route over the other.[13] Some tumors do not contain a ... The analyses of the study show that complications were more likely in patients with pre-operative comorbidities. Patients older ... and the remission rate in patients with macroadenomas are lower than 65%.[14] patients with persistent disease after initial ...
... guidelines which recommend therapy for all patients with T-cell counts of 350 or less, or in certain patients commencing at an ... studies to accurately measure the impact of health insurance on an individual's health and eliminate potential selection bias ... Medicaid patients had cut in half the probability of requiring loans or forgoing other bills to pay for medical costs.[114] ... 9,032).[78] Medicaid super-utilizers were more likely than other Medicaid patients to be male and to be aged 45-64 years.[78] ...
Sánchez Viera M (July 2015). "Management of acne scars: fulfilling our duty of care for patients". The British Journal of ... and product selection". The Journal of Clinical and Aesthetic Dermatology. 6 (12): 19-27. PMC 3997205. PMID 24765221.. ... Fife D (April 2016). "Evaluation of Acne Scars: How to Assess Them and What to Tell the Patient". Dermatologic Clinics (Review ... Yin NC, McMichael AJ (February 2014). "Acne in patients with skin of color: practical management". American Journal of Clinical ...
Patients who are immunocompromised, either with HIV/AIDS or as a result of chemotherapy, may require systemic treatment with ... In recurrent oral candidiasis, the use of azole antifungals risks selection and enrichment of drug-resistant strains of candida ... Sometimes the patient describes the raised pseudomembranes as "blisters." Occasionally there can be dysphagia (difficulty ... "Candida infection and colonization among non-trauma emergency surgery patients." Virulence 1.5 (2010): 359-366. Lalla, RV; ...
... s benefit patients by helping health care providers diagnose and treat patients and helping patients overcome ... The ASTM F04.15.17 task group is working on several new standards that involve designing implants for cleaning, selection and ... Medical monitors allow medical staff to measure a patient's medical state. Monitors may measure patient vital signs and other ... or patients over 65 years of age. [42] The law encourages patient diversity in clinical trials submitted to the FDA for review ...
A comparison between adult patients and children". Digestion. 15 (4): 260-70. doi:10.1159/000198011. PMID 863130.. ... Studies indicate that A1::DQ2 prominence is likely due to positive selection in the pre-Neolithic period and isolation in ... In one study 65% of patients with end stage autoimmune hepatitis had coeliac associated HLA-DQ (DQ2, DQ8), of these half had ... In systemic lupus erythematosus (SLE) patients HLA DR3-DQ2.5-C4AQ0, which was strongly associated with SLE (odds ratio [OR] 2.8 ...
However, this procedure carries a very high risk of failure and the patient will likely require a heart transplant. Another ... Candidate Selection, Technique, and Results of Successful Intervention". The Journal of Circulation. 110: 2125-2131. doi: ...
Granular activated carbon selection Archived 2012-09-12 at the Wayback Machine. Published 2012-05-8, retrieved 2012-09-21. ... Hemoperfusion is a treatment technique in which large volumes of the patient's blood are passed over an adsorbent substance in ...
... sexual selection or artificial selection on one trait favors one allele, while selection on other traits favors a different ... Photomicrograph of normal-shaped and sickle-shape red blood cells from a patient with sickle cell disease ... Natural selection favors genes that are more beneficial prior to reproduction than after (leading to an increase in ... Directional selection for both traits during the same time period would increase the positive correlation between the traits, ...
... for an expanded selection of reptiles and amphibians basically similar to that of Linnaeus.[12] Today, the two groups are still ... "Rattlesnake bite in a patient with horse allergy and von Willebrand's disease: case report". Can Fam Physician. 42: 2207-2211 ...
In addition, one of the most important ("first rank") diagnostic symptoms of schizophrenia is the patient's delusion of being ... The selection process is deterministic, although it may be based on earlier preferences established by the same process. ... Presented at the 2007 Summer Institute in Informed Patient Choice, Dartmouth Medical School, NH ...
A 2016 meta-analysis on the effects of music therapy in schizophrenic patients showed that the treatment in patients who ... Sometimes there are vocal selections involved in Celtic music, adding to the appeal of the song choice. ... a patient may eventually be able to produce the phrase verbally without singing.[46] As the patient advances in therapy, the ... The therapist then sings the phrase with the patient, and ideally the patient is eventually able to sing the phrase on their ...
The theory of evolution by natural selection, by Charles Darwin. *A way of understanding natural selection with Mendelian ... Addenbrooke's Hospital is where the medicine students go to learn how to cure patients. The Judge Business School is another ... In biology, Charles Darwin made his theory about natural selection while Francis Crick and James D. Watson discovered the ...
... elevated expression of RAD51 is correlated with decreased patient survival. There are also some reports of under-expression of ... This was interpreted as selection for increased RAD51 expression and thus increased homologous recombinational repair (HRR) (by ... "High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients". Br. J ... expression characterize estrogen receptor-positive/progesteron receptor-negative breast cancer and is associated with patient's ...
In order to home in on the desired information, some selection must occur. This selection is thought to occur post-retrieval in ... In an effort to find a cause for this problem, these researchers looked at the brains of schizophrenic patients. It had been ... Researchers found that there is a discrepancy in the way white matter and grey matter develop in schizophrenic patients. ... They found that schizophrenic patients had dramatically reduced white matter. As the brain develops, connectivity of different ...
... transparency and institutional review board oversight involved in the screening and selection of prospective patients. ... The long-term functionality varies patient to patient and is affected by several factors including level of amputation and ... "Patient makes dramatic recovery from amputation to transplanted hand". UCLA Newsroom. Retrieved 2017-05-23.. ... Those patients who are dedicated to taking the medications and performing the physical therapy following a hand transplant have ...
Survival curves of 272 patients over a maximum period of 24 months (author's transl)]". Giornale Italiano di Cardiologia. 8 (4 ... "TATA Box Insertion Provides a Selection Mechanism Underpinning Adaptations to Fe Deficiency". Plant Physiology. 173 (1): 715- ... An accumulation of these polyglutamine-TBP cells will occur, as shown by protein aggregates in brain sections of patients, ... "Subcutaneous absorption of insulin in insulin-dependent diabetic patients. Influence of species, physico-chemical properties ...
Suggestions for Thought: Selections and Commentaries. ISBN 0-8122-1501-X. Retrieved 6 July 2010.. ... There was no equipment to process food for the patients. " This frail young woman [...] embraced in her solicitude the sick of ... The Dickens character Sarah Gamp, who was more interested in drinking gin than looking after her patients, was only a mild ... She detailed the health conditions, physical descriptions, dietary information, and other vital details of patients whom she ...
GTPase activity of different mutant forms of p21, one cloned from a patient with myeloblastic leukaemia and one derived from in ... Direct selection on these mutants allowed catalytic properties of B-lactamase to be identified and allowed structure-function ...
Patient studies have surmounted a large amount of evidence demonstrating that the left side of the brain is more suitable for ... whereas alteration of pitch information disrupts the selection of appropriate actions, but not their timing. This suggests that ... Gosselin, Peretz, Johnsen and Adolphs (2007) studied S.M., a patient with bilateral damage of the amygdala with the rest of the ... Functional neuroimaging studies, as well as studies of brain-damaged patients, have linked movement timing to several cortical ...
Kin selection.[7] That animals and humans are more altruistic towards close kin than to distant kin and non-kin has been ... these brain-damaged patients coldly came up with "end-justifies-the-means" answers, leading Damasio to conclude that the point ... Bell, Graham (2008). Selection: the mechanism of evolution. Oxford: Oxford University Press. pp. 367-368. ISBN 0-19-856972-6.. ... Group selection. It has controversially been argued by some evolutionary scientists such as David Sloan Wilson that natural ...
... explained to patients, and applied to patient care. ... Specialty SelectionEdit. Different specialties differ in length ... Some argue that it remains unclear whether patient safety is enhanced or harmed by a reduction in work hours which necessarily ... The first year of practical patient-care-oriented training after medical school has long been termed "internship." Even as late ... However, interns and residents may not assume responsibility for a new patient after 24 hours. ...
... comparative reproductive advantage of human social behavior based on empathy and altruism in the context of natural selection.[ ...
Reports from anesthesiologists and surgeons cite proper selection, inspection, and maintenance of equipment as important safety ... except when the patient is contraindicated for tourniquet use (such as in sickle cell anemia, where there is a risk of massive ... improper equipment use or selection, and technical error are prominent factors in most cases of morbidity related to IVRA.[4][7 ... 8][9] Modern practice now includes various safeguards to improve patient safety. ...
Single/Double Lung Patient Selection Criteria. General Indications. All patients considered for pulmonary transplantation shall ... Heart-Lung Patient Selection Criteria. General Indications. In the past, it has been shown that pulmonary transplant as a ... Pancreas Patient Selection Criteria. Indications. *Group I: Insulin-dependent Diabetes Mellitus Type I (JODM) with secondary ... Patient selection criteria as published in the September 2006 issue of "Journal of Heart and Lung Transplantation", Vol. 25, pp ...
When evaluating a patient with an inguinal hernia and considering a laparoscopic or endoscopic approach, several factors need ... but is as important in patient selection and choice of operation. Proper patient selection would require a panoramic view of ... Iskandar M., Ferzli G. (2018) Patient Selection for Laparoendoscopic Inguinal Hernia Repair. In: Bittner R., Köckerling F., ... When evaluating a patient with an inguinal hernia and considering a laparoscopic or endoscopic approach, several factors need ...
Patients with neurological disease origins. BOWEL CONTROL CANDIDATES. A broad range of chronic fecal incontinent patients are ... Sacral Neuromodulation is not appropriate for patients who:. *Have not demonstrated an appropriate response to the evaluation ( ... Sacral Neuromodulation, delivered by the Interstim™ system, is indicated for patients who have failed or could not tolerate ... A broad range of patients with overactive bladder and non-obstructive urinary retention are considered suitable for Sacral ...
Learn more about patient criteria for this therapy. ... Deep brain stimulation therapy may be an option for patients ... IS DBS THERAPY RIGHT FOR YOUR PATIENT? Download the patient candidacy tool and assess your patient now. ...
Artificial urinary sphincter Incontinence Management Surgical technique Patient selection This is a preview of subscription ... Pariser J.J., Cohen A.J., Rosen A.M., Bales G.T. (2016) Artificial Urinary Sphincter: Patient Selection and Surgical Technique ... and this chapter will focus on the essential aspects of patient selection and operative technique. ... Urethral buttressing in patients undergoing artificial urinary sphincter surgery. J Urol. 2013;189:1777-81.CrossRefPubMedGoogle ...
Patient Selection. As with other interventional procedures, proper patient selection increases the chances of a favorable ... Kircelli A, Coven I, Cansever T, Sonmez E, Yilmaz C. Patient Selection and Efficacy of Intradiscal Electrothermal Therapy with ... Patients with severe radicular symptoms due to a herniated disk or patients with severe spinal stenosis are not good candidates ... 4] Sixty-two patients were selected for IDET from a pool of 1116 patients with low back pain who did not respond to at least 6 ...
... Guest Editors: Natan Zundel, Sayeed Ikramuddin, and ... Optimizing Outcomes in Bariatric Surgery: A Primer in Patient Selection, Natan Zundel, Sayeed Ikramuddin, and Raul Rosenthal ... Perioperative Optimization of Patients Undergoing Bariatric Surgery, C. E. Owers, Y. Abbas, R. Ackroyd, N. Barron, and M. Khan ... Candidates for Bariatric Surgery: Morbidly Obese Patients with Pulmonary Dysfunction, Yu-Feng Wei and Huey-Dong Wu Volume 2012 ...
... by the FDA to serve as an adjunct to the dentists professional judgment of how to best use diagnostic imaging for each patient ... A study of 490 patients found that basing selection criteria on clinical evaluations for asymptomatic patients, combined with ... Patient Selection Criteria. Radiographs and other imaging modalities are used to diagnose and monitor oral diseases, as well as ... The guidelines titled, "The Selection of Patients for X-Ray Examination" were first developed in 1987 by a panel of dental ...
How to select patients for antireflux surgery? The ICARUS guidelines (international consensus regarding preoperative ... examinations and clinical characteristics assessment to select adult patients for antireflux surgery) Ans Pauwels, Veerle ...
Clinical trial execution can be hindered by patient and investigator frustrations. Learn how Parexel can help to streamline ... and patients. Our Patient Recruitment and Strategy Group gives you solutions to identify volunteers, then keep them engaged ... Patient recruitment materials provided site investigators and Consent+, our award-winning electronic informed consent platform ... A new paradigm in development to reimburse investigators within 60 days of patient visit, rather than the typical 6 months ...
This fact points to a stricter selection of patients with high medical risks and therefore to better discrimination of patients ... Patient Selection for Carotid Endarterectomy. How Far Is Risk Modeling Applicable to the Individual?. Alain Barth, Claudio ... The selection criteria of Rothwell et al were prospectively applied to all patients without influencing the decision to operate ... In the present study, the selection model of Rothwell et al10 was prospectively applied to a consecutive series of patients ...
Patient Selection Overview. Over the past decade several clinical trials have demonstrated that proper patient selection are ...
patient selection strategy linked to target expression on the tumor is thus critically important.... ... "The development of a patient selection strategy linked to target expression on the tumor is thus critically important for ... Article Highlights Importance of Careful Patient Selection in Mesothelioma Immunotherapy Treatment, According to Surviving ... Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions. ...
... medical ethicists are discussing how to make decisions on if and when patients should be eligible for the costly and complex ... For Face Transplant Patients, Selection Criteria Could Stiffen in Future. * By Dan Childs ... Rather, facial transplant patients are largely selected by a process of elimination -- those patients for whom other surgeries ... "Most programs do exclude patients who are non-compliant or not adherent with medical therapy, and most exclude patients who ...
Home › EAU News › All › Patient selection: crucial in RCC treatment. Patient selection: crucial in RCC treatment. 26 February ... With the entry of so-called targeted therapy (TT), patient selection and individualised treatment strategies will become more ... Bex, meanwhile, stressed in his lecture that patients selection will prove crucial. ... "Its all about selection," Bex said. In his concluding remarks he underscored the following:. - There is no evidence supporting ...
The male factor of infertility should not be an issue for the selection of patients for extended embryo culture programmes. ... Uterus transplantation for absolute uterine factor infertility: Ethics, patient selection, and consent. Authors. Mats ... This topic will discuss the ethics, indications, and patient selection for uterus transplantation, an experimental approach to ... The purpose of this topic is to provide information on this developing technology for clinicians and patients; the topic is not ...
While "good patient selection" may sound like a simple objective, achieving good patient selection remains a constantly ... Patient selection in TEVAR requires better risk stratification to better select patients for this new procedure. ... By using these guidelines to improve patient selection, our risk models can help patients, physicians, and policymakers improve ... By using these guidelines to improve patient selection, our risk models can help patients, physicians, and policymakers improve ...
To the Editor We congratulate Grant et al1 on their multi-centre study on the impact of endoscopic vein harvesting (EVH) on clinical outcomes. Their results echoed nicely with the studies by Dacey et al2 and Ouzounian et al3 who showed EVH is not an independent predictor of inhospital or mid-term adverse outcomes. However, it is interesting to note that only 12.4% of their studied population received EVH. The study also highlighted the … ...
Use of lung transplantation survival models to refine patient selection in cystic fibrosis.. Liou TG1, Adler FR, Huang D. ... Identifying characteristics that affect post-transplantation survival may improve patient selection and survival benefit. Using ... Transplantation never improves survivorship for pediatric patients. Patients with arthropathy, B. cepacia infection, or younger ... Adult patients with low 5-year predicted survival without B. cepacia infection should receive priority for lung transplantation ...
Patient Selection for Urodynamic Studies. The history and physical examination alone may not provide sufficient and accurate ... Selection of patients for complex urodynamic testing can be difficult. Universally agreed-upon criteria for complex testing do ... Patients with low flow rates may be at risk for prolonged catheterization. In one study, 38% of the patients with abnormal ... Patient position during testing varies, but most commonly, the patient is sitting, semi-erect, or standing. The catheters ...
The relationship of patient selection to prognosis following aortocoronary bypass.. M J Conley, A S Wechsler, R W Anderson, H N ... The relationship of patient selection to prognosis following aortocoronary bypass.. M J Conley, A S Wechsler, R W Anderson, H N ... The relationship of patient selection to prognosis following aortocoronary bypass.. M J Conley, A S Wechsler, R W Anderson, H N ... This apparent variation in operative mortality over time was largely a consequence of changing patterns of patient selection, i ...
The entire paper can be read here ACTIVE SURVEILLANCE FOR PROSTATE CANCER: PATIENT SELECTION AND MANAGEMENT. Diagnosed 96: Age ... Active surveillance for prostate cancer: patient selection and management L. Klotz, MD is a paper published in last months ... HealingWell.com Forum , Diseases & Conditions , Prostate Cancer , Active surveillance patient selection and management ... By the way, I dont really think your "Main Uro" would be so stupid as to say that 30% of AS patients die of PC. My guess is ...
Change of Patient Selection Strategy and Improved Surgical Outcome in MRI-negative Neocortical Epilepsy.. Moon HJ1, Kim DW2, ... The new patient selection strategy led to a significant increase in the concordance between two or more modalities. The ... as a new patient selection strategy for MRI-negative neocortical epilepsy surgery. The objective of this study was to evaluate ... The old group consisted of 89 patients and the new one consisted of 53 patients. Clinical characteristics, presurgical ...
... to support patient selection and efficacy evaluation in its global clinical trials, Aprinoia said, through a deal whose value ... Home Neurological Disorders Alzheimers Celgene Licenses Aprinoia Tau PET Tracer APN-1607 to Support Patient Selection in... ... Celgene Licenses Aprinoia Tau PET Tracer APN-1607 to Support Patient Selection in Trials. January 2, 2019. 0 ... to support patient selection and efficacy evaluation in its global clinical trials, Aprinoia said today, through a deal whose ...
... simple and practical quantitative scores or indices suitable for deciding a pre-liver transplantation work-up in patients with ... Selection of patients with parenchymal cirrhosis for hepatic transplantation] Acta Gastroenterol Belg. Mar-Apr 1990;53(2):261-6 ... simple and practical quantitative scores or indices suitable for deciding a pre-liver transplantation work-up in patients with ...
Clinical indicators results for Memorial Hermann hospitals when compared to the current benchmarks for antibiotic selection for ...
Careful selection of high-risk patients for immediate intervention with locoregional muscle flaps may reduce surgical ... Appropriate patient selection may yield reduced morbidity in spinal resection. Devulapalli C, et al. Plast Reconstruct Surg. ... Careful selection of high-risk patients for immediate intervention with locoregional muscle flaps may reduce surgical ... Careful selection of high-risk patients for immediate intervention with locoregional muscle flaps may reduce surgical ...
Corus CAD is intended for use in stable patients presenting with non-acute typical and atypical symptoms suggestive of ... Corus CAD Patient Selection The Corus CAD test is intended for use in patients who present with stable symptoms suggestive of ...
... Insights From: Ezra Cohen, MD, Moores Cancer Center; UC San Diego Health; Jared Weiss, MD ... For instance, if a patient is symptomatic from their disease and a response is important, thats a patient I would often ... For instance, if a patient is symptomatic from their disease and a response is important, thats a patient I would often ... In contrast, if I have a patient whos not terribly symptomatic from their apparent progression-in particular, the patient says ...
... today announced the joint development of a decision support system that allows clinicians and patients to choose from available ... Pharmacotherapy selection system supports shared clinician-patient decision-making in diabetes treatment. ... Pharmacotherapy selection system supports shared clinician-patient decision-making in diabetes treatment ... Pharmacotherapy selection system supports shared clinician-patient decision-making in diabetes treatment ...
... when matching patients and physicians on the basis of value and quality rather than costs and outcomes can help a patient ... Patient-Centered Physician Selection: A Necessary First Step for Accountable Care. Brian Powers, BA and Sachin H. Jain MD, MBA ... There is a notable gap in our system wide efforts to promote accountable, patient-centered care: physician selection. The past ... Patients are sensitive to system characteristics such as wait times, the use of patient portals, physician use of electronic ...
  • Only with rigid selection criteria has clinical success been realized. (osotc.org)
  • There is a "transplant window" during which the patient has a gradual decline from the natural history of his/her disease, but has not deteriorated so much that he/she is no longer a viable transplant candidate. (osotc.org)
  • Patients with the following disease processes are considered as candidates for transplantation. (osotc.org)
  • Physical function and quality of life outcomes in highly selected patients have improved. (medscape.com)
  • The objective of this study was to evaluate the surgical outcomes of MRI-negative neocortical epilepsy patients before and after the implementation of a new selection strategy. (nih.gov)
  • Improving attention paid to patient preferences when matching patients and physicians on the basis of value and quality rather than costs and outcomes can help a patient achieve the overall healthcare experience. (ajmc.com)
  • Even recent efforts to bring more transparency and consumer choice to healthcare decisions focus primarily on costs and outcomes, 1 and neglect other domains of the patient experience. (ajmc.com)
  • David Eichenbaum, MD, demonstrates how drug selection can affect outcomes over time by sharing the cases of two patients with age-related macular degeneration. (eyetube.net)
  • Disease management (DM) programs provide a systematic approach to optimizing care and outcomes for patients with heart failure (HF), the treatment of which is often complicated by one or more coexisting conditions, polypharmacy, psychosocial factors, health literacy issues, and economic concerns. (oncologynurseadvisor.com)
  • To describe short-term clinical and echocardiography outcomes in patients undergoing transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR). (diva-portal.org)
  • 2, 3 ] Outcomes assessment is primarily designed to establish baselines, to evaluate the effect of an intervention, to assist in goal setting, and to motivate patients to evaluate their treatment. (chiro.org)
  • UW Health is one of the national leaders in outcomes using left ventricular assist devices for patients with end-stage heart failure. (uwhealth.org)
  • This study aimed to analyze the treatment outcomes, particularly infield progression, and severe late toxicity rates after reRT for recurrent rectal cancer and further identify a subgroup of patients who may optimally benefit from reRT. (frontiersin.org)
  • Paramount to the recent progress observed with this therapy has been a greater understanding of patient selection criteria as a primary determinant of early and late patient outcomes. (semanticscholar.org)
  • Prior to device implant, patients should undergo a multidisciplinary evaluation of cardiovascular, noncardiovascular, and psychosocial factors that influence postoperative outcomes. (semanticscholar.org)
  • This heterogeneity may explain why HRQL or other patient-related outcomes may differ in individuals during, or following any treatment or intervention. (springer.com)
  • Patient-reported outcomes are relatively poorly defined to date. (springer.com)
  • Since HRQL has only been studied in relatively few oral immunotherapy trials to date, primarily looking at caregiver HRQL, it is unclear which factors, measures, or subscales are most predictive of short- and/or long-term treatment outcomes for which type of patient, and which time points for measurement are most informative. (springer.com)
  • A standardised protocol that incorporates HRQL and other relevant patient-related outcome measures and agreed definitions of outcomes would allow for the comparison of efficacy of food allergy treatments between centres, trials, or countries. (springer.com)
  • Further evidence-based research aimed at exploring the effects of interventions on outcomes in food allergy is needed, including the influence of patient and parent factors on protocol design. (springer.com)
  • To this end, it is vital that patient-related outcomes such as improved HRQL are seen as a primary outcome and are measured at multiple intervals during the trial duration and beyond. (springer.com)
  • Long term follow up of the Sheffield data set has shown that patient selection has the most impact on reducing adverse outcomes from the procedure. (bl.uk)
  • The aim of the study was to assess the long-term clinical outcomes of patients who underwent LAGB at a single bariatric center and to examine the variables associated with patients' adherence to scheduled appointments after bariatric surgery. (termedia.pl)
  • Outcomes were compared between SHARP eligible and non-eligible patients. (eur.nl)
  • METHODS AND RESULTS Twelve registries provided data in a systematic manner on outcomes in STEMI patients overall, and seven of these also provided data for P2Y12 receptor inhibitor-based dual antiplatelet therapy. (uzh.ch)
  • The outcomes of men who are not treated for prostate cancer is dependent on cancer grade (the higher the grade the more aggressive), the life expectancy of the patient with the disease, and whether or not the cancer was detected through screening. (wikipedia.org)
  • A tailored approach that takes into consideration patient-related, anesthesia-related, and surgeon-related factors offers the best outcome and reduces complications and recurrences. (springer.com)
  • As with other interventional procedures, proper patient selection increases the chances of a favorable outcome. (medscape.com)
  • Change of Patient Selection Strategy and Improved Surgical Outcome in MRI-negative Neocortical Epilepsy. (nih.gov)
  • In the premarket studies, the survival rate was 73.3%. 'The primary reason for the difference in survival outcome appears to be patient selection,' FDA said in a letter to doctors. (medworm.com)
  • The patient underwent high-risk stenting of the left subclavian artery with a successful outcome. (medworm.com)
  • QyPredict ® technology relies on both the patient's MRI and clinical data that are included in machine learning algorithms, to provide an automated prediction of the trial primary outcome based on the patient profile. (prnewswire.com)
  • Precise patient selection is necessary for interventions and to improve the outcome and reduce the risk and possible complications. (dovepress.com)
  • Patient selection is particularly important for successful subthalamic nucleus (STN) deep brain stimulation (DBS), because a number of factors determine positive surgical outcome. (medscape.com)
  • The purpose of this literature review was to synthesize the existing literature on various definitions, classifications, selection criteria, and outcome measures used in different studies in patients with neck pain. (chiro.org)
  • One objective of this study is to provide to health care professionals who work with patients with neck pain some useful information about the existing outcome measures and the criteria for selecting the most appropriate ones according to treatment goals. (chiro.org)
  • The aim of this study was to investigate how this selection influences the outcome in rectal cancer regardless of dose or fractionation of RT. (diva-portal.org)
  • E xtent of resection remains a critical determinant of oncological outcome for patients with high- and low-grade glioma. (thejns.org)
  • British Library EThOS: When working towards an optimised carotid stenting procedure does patient, procedural and pharmacological selection impact on outcome? (bl.uk)
  • Although the added value of FDG-PET in the diagnostic work-up is well established, it is unclear from current studies, whether more sensitive and meticulous preoperative staging has an impact on patient outcome. (knowcancer.com)
  • For example, a randomized trial comparing chemotherapy alone to chemotherapy with erlotinib, EGFR -mutated patients had a superior outcome regardless of the therapy ( 19 ). (aacrjournals.org)
  • Our team uses a broad spectrum of left ventricular assist devices (LVAD), tailoring selection to meet each patient's individual needs. (uwhealth.org)
  • Patient selection for left ventricular assist devices. (semanticscholar.org)
  • Since accurately picking drugs to fight patients' unique tumor mutations remains in large part a guessing game, researchers have been working on finding better approaches. (medgadget.com)
  • They discovered that similar mutations occur in the cancers and their corresponding organoids, pointing to the use of organoids as an accurate platform for drug selection. (medgadget.com)
  • The 2004 finding that patients with mutations in EGFR were more likely to respond to gefitinib triggered a spate of retrospective studies. (cancernetwork.com)
  • FLT3 somatic variants are among the most common driver mutations with the strongest effects on the overall survival in acute myeloid leukemia 1 (AML), the most deadly form of leukemia, which is diagnosed in about 20,000 new patients each year in the U.S. and has only a 26.6 percent five-year survival rate 2 . (globenewswire.com)
  • Used in combination with Invivoscribe's proprietary MyInformatics ® Software these assays identify and can track primary driver mutations as well as the subclonal architecture and emergence of new driver mutations in patients with hematologic disease. (globenewswire.com)
  • The exciting discovery that certain mutations in the tyrosine-binding domain of the EGFR receptor were associated with objective response to EGFR TKIs brought renewed interest in molecular selection of patients ( 12 , 13 ). (aacrjournals.org)
  • Some large phase II trials in Caucasian patients failed to show a significant association between EGFR mutations and survival ( 25 , 26 ). (aacrjournals.org)
  • The predictive value of EGFR mutations could depend on the type of EGFR mutation and/or the genetic background of patients. (aacrjournals.org)
  • Hence, it's very important that patients are selected where the surgeon thinks that he or she can get to no evidence of disease because if they don't, there's a possibility those patients are going to fare worse than if they never underwent surgery in the first place. (healio.com)
  • Patients with rectal cancer who underwent reRT to the pelvis between January 2000 and December 2017 were included for analysis. (frontiersin.org)
  • Methods: Data from the Swedish Colorectal Cancer Registry and the Swedish National Patient Register on all patients without distant metastasis who underwent elective trans-abdominal surgery for rectal cancer 2000-2010 in the Stockholm Gotland region was retrieved. (diva-portal.org)
  • We performed a retrospective review of patients who underwent LAGB between 2004 and 2009. (termedia.pl)
  • Strengthening the attention to patient preferences in this critical first step of a patient's healthcare experience is critical if patients are going to become engaged partners in their care and form strong therapeutic alliances with their physicians. (ajmc.com)
  • Nonetheless, for patients that need additional proven therapeutic combinations down the line when they've already had, for example, pertuzumab and T-DM1 or capecitabine, the eribulin and trastuzumab combination is a combination that has proven efficacy and safety. (onclive.com)
  • Accurate preprocedural evaluation of patients who are candidates for TAVI is mandatory to plan the most adequate therapeutic approach and to select the prosthesis size. (bmj.com)
  • Aim: To assess sorafenib efficacy and safety in SHARP eligible and non-eligible patients, and determine the validity of the current therapeutic indication as described by the FDA/EMEA. (eur.nl)
  • In summary, the artificial urinary sphincter is a success story, and this chapter will focus on the essential aspects of patient selection and operative technique. (springer.com)
  • However, in selected subgroups of patients, the operative risk may outweigh the clinical benefits of surgery. (bmj.com)
  • w4 The reported procedural success rates range between 94-98% with acceptable procedure related complication rates (5-18%), bearing in mind the high operative risk of the patients. (bmj.com)
  • In this review, the authors describe facets of functional neuroimaging techniques that may limit their impact on neurosurgical oncology and critically evaluate the evidence supporting fMRI and DTI for patient selection and operative planning in glioma surgery. (thejns.org)
  • 1 , 7 , 10 , 11 , 17 , 39 , 44 Therefore, the objective of this review is to detail nuances of functional neuroimaging techniques that may limit the ability of these techniques to impact neurosurgical oncology and to critically appraise the evidence supporting fMRI and DTI in glioma surgery for patient selection and operative planning. (thejns.org)
  • For instance, if a patient is symptomatic from their disease and a response is important, that's a patient I would often consider treating with cytotoxic chemotherapy-usually with a doublet or the extreme regimen that adds cetuximab. (onclive.com)
  • On the other hand, in patients who may not tolerate cytotoxic chemotherapy, where a response is not necessarily the most important thing I want to achieve-and, obviously, survival comes into play-that's a patient where an anti-PD-1 antibody may be a better selection versus cytotoxic chemotherapy. (onclive.com)
  • In patients who, for instance, may not necessarily tolerate a cytotoxic chemotherapy very well and perhaps have a relative contraindication to immunotherapy, that's where cetuximab plays an important role. (onclive.com)
  • Patient selection for oral chemotherapy. (semanticscholar.org)
  • Several distinct issues, apart from the usual criteria for selecting patients for intravenous chemotherapy, dictate patient selection for these drugs. (semanticscholar.org)
  • Patient education: the cornerstone of successful oral chemotherapy treatment. (semanticscholar.org)
  • Patient preferences for oral versus intravenous palliative chemotherapy. (semanticscholar.org)
  • Bladder cancer, widely considered as an underfunded area in urological malignancies, requires a more refined clinical staging if patients are to optimally benefit from treatment such as neoadjuvant chemotherapy (NAC). (uroweb.org)
  • Dinney, who will lecture on optimising patient selection for neoadjuvant chemotherapy during a session on high-grade bladder cancer, said that although NAC is known to improve the survival of patients with muscle invasive bladder cancer (MIBC), NAC is under-utilised due to the modest number of patients who actually benefit and the inability to identify those likely to respond prior to treatment. (uroweb.org)
  • Greater patient selection may be needed for first line nivolumab to improve progression-free survival over chemotherapy in advanced lung cancer as the CheckMate 026 trial gave negative results in a broad group of patients expressing PD-L1 in their tumour cells. (medicalxpress.com)
  • The phase III CheckMate 026 trial investigated the efficacy of first line treatment with nivolumab compared to platinum-based doublet chemotherapy in patients with advanced NSCLC and PD-L1 positive tumours (defined as present in 1% or more tumour cells). (medicalxpress.com)
  • A total of 541 patients were randomised 1:1 to nivolumab or chemotherapy. (medicalxpress.com)
  • Patients who progressed on chemotherapy could crossover to nivolumab as second line treatment. (medicalxpress.com)
  • In the 423 patients with 5% or greater PD-L1 expression, progression-free survival was 4.2 months with nivolumab and 5.9 months with chemotherapy (hazard ratio [HR] 1.15, 95% confidence interval [CI] 0.91-1.45, p=0.25). (medicalxpress.com)
  • Among all treated patients, any and serious treatment-related adverse events were 71% and 18% with nivolumab, and 92% and 51% with chemotherapy, respectively. (medicalxpress.com)
  • Overall survival in the chemotherapy arm was better than historical standards, which could be due to the fact that it had a greater proportion of women and Asian patients. (medicalxpress.com)
  • Platinum-based chemotherapy is the standard first line treatment because it makes patients live longer and palliates symptoms," said Socinski. (medicalxpress.com)
  • IDET should be considered in patients who have had diskogenic low back pain for more than 6 months and whose condition has not responded to conservative treatment. (medscape.com)
  • 1,2 The model was tested and validated in 990 ECST patients with 70% to 99% carotid stenosis assigned to endarterectomy (n=596) or medical treatment only (n=394). (ahajournals.org)
  • The development of a patient selection strategy linked to target expression on the tumor is thus critically important for identifying the population appropriate for receiving treatment," the two conclude. (prweb.com)
  • Although an ADC like anetumab ravtansine appears to offer new hope for mesothelioma treatment, this article reminds us that these drugs are only effective in the right patients and may be a waste of time and resources for others," says Alex Strauss, Managing Editor for Surviving Mesothelioma. (prweb.com)
  • We had a very balanced session where we looked for optimal treatment modalities in kidney cancer patients. (uroweb.org)
  • so that we can exchange the results and learn from each other what kind of treatment is best for what kind of patient. (uroweb.org)
  • By facilitating patient-clinician communication and supporting shared-decision making, the goal is to make sure that patients are fully engaged and committed to the treatment plan. (hitachi.com)
  • Therefore, the patients should be discussed in a multidisciplinary approach prior to determining the most appropriate treatment for lung volume reduction. (dovepress.com)
  • Thus, dental and facial esthetics is the common aim for all patients seeking dental treatment. (hausarbeiten.de)
  • In acute ischemic stroke, the first objective is to restore brain flow using sistemic thrombolytic treatment and, in patients with large vessel occlusion, by endovascular treatment. (coursera.org)
  • The RACE scale is a prehospital scale validated as a tool to identify patients with suspected large vessel occlusion who are potential candidates for endovascular treatment. (coursera.org)
  • Based on the review of these studies and our own experience, recommendations are made for the selection of the appropriate candidates for expectant treatment, criteria for maternal-fetal monitoring, and targets for delivery. (biomedsearch.com)
  • To explore patient selection criteria for treatment with TAVI. (diva-portal.org)
  • Additionally, in what ordinarily required a face-to-face visit with a medical professional, patients can use computer-based decision aids to help them navigate complex decisions about treatment options - often without leaving the comforts of home. (hearinghealthmatters.org)
  • Study subjects will be offered treatment involving the use of the CliniMACS® Reagent System (Miltenyi Biotec), a CD34+ selection device to remove T-cells from a peripheral blood stem cell transplant in order to decrease the risk of acute and chronic GVHD. (clinicaltrials.gov)
  • LAS VEGAS -Methadone is not an appropriate pain treatment option for all patients and its complicated pharmacokinetics, metabolism and drug interactions necessitate careful patient selection and conversion. (empr.com)
  • ReRT was a reasonable treatment option for patients with locoregionally recurrent rectal cancer. (frontiersin.org)
  • However, despite advances in treatment modalities, local recurrences still occur in 5-15% of patients, and the majority of locoregional recurrences occur within the initial RT field ( 5 , 6 ). (frontiersin.org)
  • Natalizumab is an integrin receptor antagonist indicated for the treatment of multiple sclerosis (MS). Natalizumab is indicated as monotherapy in patients who have had an inadequate response to other forms of MS treatment and is not recommended as first-line treatment because of the potential for serious adverse events associated with its use. (ajmc.com)
  • Physicians and patients must weigh the benefits of treatment against the possibility of developing PML before undergoing treatment. (ajmc.com)
  • Natalizumab is indicated as monotherapy for the treatment of patients with relapsing forms of MS to delay the accumulation of physical disability and reduce the frequency of clinical exacerbations. (ajmc.com)
  • This test approval will be of substantial benefit to patients afflicted with AML and is a critical tool for healthcare providers to identify the most appropriate treatment for newly diagnosed FLT3 -mutated AML patients, furthering the promise of personalized molecular diagnostics and precision medicine," said Dr. Jeffrey Miller, CSO & CEO of Invivoscribe. (globenewswire.com)
  • I wanted to see a more formal treatment plan for patients with bothersome tinnitus. (audiologyonline.com)
  • In addition, it is important to limit exposure of ADCs to patients who will benefit from treatment due to the significant off-target toxicities associated with these molecules ( 1, 2 ). (aacrjournals.org)
  • Nivolumab represents a standard of care in the second-line treatment of advanced non-small cell lung cancer (NSCLC) as it improved overall survival compared to docetaxel in phase III trials in these patients," said lead author Dr Mark A. Socinski, Executive Medical Director, Florida Hospital Cancer Institute, US. (medicalxpress.com)
  • He continued: "More research is needed about how to use the PD-L1 biomarker to select patients for treatment with nivolumab. (medicalxpress.com)
  • RESULTS: In total, 211 of 247 patients (70% TS-H) were registered to the treatment phase. (healthpartners.com)
  • Efficacy analyses included eligible patients who had started treatment (N = 186). (healthpartners.com)
  • Balloon angioplasty with or without stent placement has been used as a treatment modality for renovascular hypertension and preservation of kidney function in patients with renal artery stenosis. (onlinejacc.org)
  • Additionally, it is estimated that as many as 55% of patients who sustain an ankle sprain do not seek evaluation or treatment from a healthcare professional. (bmj.com)
  • This allowed treatment of SHARP non-eligible patients in daily clinical practice. (eur.nl)
  • The registries were heterogeneous in terms of site, patient, and treatment selection, as well as in definition of endpoints (e.g. bleeding events). (uzh.ch)
  • In the meantime, active surveillance for the treatment of low risk prostate cancer is now being offered to more and more patients where it is generally considered that prostate cancer will not cause the man harm during his lifetime if treatment is delayed or avoided. (wikipedia.org)
  • So while there are standard exclusion criteria for some forms of organ transplant -- for example, a patient in need of a liver may be denied a spot on the UNOS waiting list if he cannot abstain from alcohol for six months before surgery -- there are currently no such restrictions for face transplant candidates. (go.com)
  • Flow chart showing patient selection according to the exclusion criteria. (nih.gov)
  • A study of 490 patients found that basing selection criteria on clinical evaluations for asymptomatic patients, combined with selected periapical radiographs for symptomatic patients, can result in a 43 percent reduction in the number of radiographs taken without a clinically consequential increase in the rate of undiagnosed disease. (fda.gov)
  • Methods- A series of patients with a recently symptomatic high-grade carotid stenosis were selected for surgery according to current guidelines and were consecutively operated on in a single institution. (ahajournals.org)
  • All patients investigated by Doppler or duplex sonography during the last 3 years in our institution were considered for inclusion in the study when a symptomatic 70% to 99% carotid stenosis was found. (ahajournals.org)
  • In my practice, for the average patient with progression on an immunotherapy drug who is symptomatic from that progression, for the most part I stop and switch them to something else. (onclive.com)
  • In contrast, if I have a patient who's not terribly symptomatic from their apparent progression-in particular, the patient says that they feel much better with their progression, the cancer is not pressing on a major airway or on a major blood vessel, and it is not causing major pain or other symptoms-I'll get another scan to see what happens. (onclive.com)
  • A broad range of chronic fecal incontinent patients are considered suitable for Sacral Neuromodulation, delivered by the InterStim system, if they have failed or are not candidates for more conservative treatments such as medication, behavior modifications, bowel retraining, and/or pelvic muscle training. (medtronic.com)
  • Ideal candidates are patients with a single affected disk as determined by magnetic resonance imaging (MRI) and diskography . (medscape.com)
  • Patients with the predominant complaint of axial pain with or without some nonradiating limp pain are suitable candidates. (medscape.com)
  • 5 However, from an epidemiological point of view, there is a need to better select the surgical candidates because only 20% to 25% of patients medically treated have a stroke or die of stroke during the following 3 years. (ahajournals.org)
  • It is crucial to make selection strategy to identify surgical candidates among medically refractory MRI-negative neocortical epilepsy patients. (nih.gov)
  • MRI-negative neocortical epilepsy patients with two or more concordance between noninvasive studies seem to be good candidates for epilepsy surgery. (nih.gov)
  • Echocardiography should be used to determine which patients are candidates for TMVR, and it should also be used after MitraClip implantation to see the results of the procedure. (acc.org)
  • They developed an algorithm that was used by expert echocardiographers to interpret the heart images, evaluate the functioning of the valve and determine whether patients were appropriate candidates for the MitraClip procedure. (acc.org)
  • Active surveillance (AS) or watchful waiting is a management option for localized prostate cancer that can be offered to appropriate patients who would also be candidates for aggressive local therapies (surgery and radiotherapy), with the intent to intervene if the disease progresses. (wikipedia.org)
  • CONCLUSIONS: TS expression was prognostic: Patients with TS-L tumors who received FOLFOX/Bev had a longer PFS than those with TS-H tumors, along with a trend toward longer OS. (healthpartners.com)
  • 8,9 Our objectives were to compare the results of both selection methods and to evaluate the accuracy of the prognostic model for the individual patient in light of our surgical results. (ahajournals.org)
  • Doing an echocardiogram is critical in determining if a patient is a good candidate for MitraClip and in following these patients to evaluate results of the procedure in the long run. (acc.org)
  • We conducted a survey of recent clinical experience from early-phase ADC trials completed between 2000 and 2019 to evaluate the different approaches to patient selection currently being used and assess whether there is evidence that target expression is associated with clinical activity. (aacrjournals.org)
  • Accordingly we aimed this retrospective study to: (1) evaluate the suitability of the standard coronary angiography to study the SNA and (2) determine if the percentage of subjects with a positive retrospective history of supra-ventricular arrhythmias (SVA) differs in patients with normal and diseased SNA ascertained at the time of coronary angiography. (nih.gov)
  • Patients with early-stage lung cancer and with a positive EGFR test have a superior survival compared with patients with a negative test. (aacrjournals.org)
  • Initial clinical studies suggested that IDET might be effective in approximately 70% of patients with chronic unremitting low back pain. (medscape.com)
  • Because of multidimensionality of chronic neck pain, more than just one index may be needed to gain a complete health profile of the patient with neck pain. (chiro.org)
  • Chronic GVHD can appear in patients without prior acute GVHD. (clinicaltrials.gov)
  • Allergic rhinitis in patients with chronic rhinosinusitis should be treated appropriately to minimize all sources of sinonasal inflammation. (enttoday.org)
  • It's critical for patients to understand that chronic sinus disease is a disease that is always with you, that it can wax and wane in severity. (enttoday.org)
  • More recently, serotonin-norepinephrine reuptake inhibitors and some anticonvulsants have been approved for painful diabetic neuropathy, fibromyalgia, and other chronic conditions, but they are even less effective than tricyclic antidepressants in most patients. (premier-research.com)
  • While research on chronic ankle instability (CAI) and awareness of its impact on society and health care systems has grown substantially in the last 2 decades, the inconsistency in participant/patient selection criteria across studies presents a potential obstacle to addressing the problem properly. (bmj.com)
  • The dentist, knowing the patient's health history and vulnerability to oral disease, is in the best position to make this judgment in the interest of each patient. (fda.gov)
  • Vascular surgeons frequently perform procedures aimed at limiting death, stroke, or amputation on patients who present with diseases such as aortic aneurysms, carotid atherosclerosis, and peripheral arterial occlusive disease. (hindawi.com)
  • By using these guidelines to improve patient selection, our risk models can help patients, physicians, and policymakers improve the clinical effectiveness of surgical and endovascular treatments for vascular disease. (hindawi.com)
  • By using these guidelines to improve patient selection, our risk models can help patients, physicians, and policymakers improve the clinical effectiveness of surgical and endovascular treatments for vascular disease [ 15 - 18 ]. (hindawi.com)
  • Of course there are tragic cases of young men dying from the disease, but as Dr Klotz says they generally have high-grade disease at the outset and represent a very small proportion of prostate cancer patients. (healingwell.com)
  • And, in a patient who's having symptoms from their disease, a response to that individual is going to be meaningful. (onclive.com)
  • Across both selected patient populations, the positive predictive value was highest in patients with chest pain, with ischaemia on the electrocardiogram, and with a history of ischaemic heart disease. (bmj.com)
  • PARIS and BOSTON , Nov. 3, 2020 /PRNewswire/ -- QYNAPSE SAS , a medical technology company, will present results on QyPredict ® , an AI prediction technology for patient selection in Alzheimer's clinical trials, at the 13th Clinical Trials on Alzheimer's Disease (CTAD) Conference. (prnewswire.com)
  • Today we are still unable to predict the rate of cognitive decline of patients with prodromal Alzheimer's disease. (prnewswire.com)
  • QYNAPSE is presenting new results at virtual 2020 CTAD Clinical Trials on Alzheimer's Disease Conference, comparing various recruitment strategies for patient enrichment using ADNI data, and evaluating the benefit of using a predictive tool such as QyPredict ® for the selection of patients in clinical trials. (prnewswire.com)
  • In patients with valvular heart disease, murmurs suggestive of aortic or mitral stenosis or regurgitation or tricuspid regurgitation may be present. (oncologynurseadvisor.com)
  • In Study 301 that compared second-line eribulin following an anthracycline and taxane and the second-line node status disease versus capecitabine study, they were similar in efficacy and in putting all patients together: the triple-negatives and the ER-positive patients. (onclive.com)
  • Sometimes, we will certainly use it if we have a heavy burden of liver metastases, but if patients have more indolent disease, a smaller burden of disease, we may hold off on the eribulin. (onclive.com)
  • Nowadays, most patients had those in their early disease setting anyway. (onclive.com)
  • What is the patient evaluation and selection process for individuals with Parkinson disease (PD) considering subthalamic nucleus (STN) deep brain stimulation (DBS)? (medscape.com)
  • The purpose of this study is to learn more about the effects of (classification determinant) CD34+ stem cell selection on graft versus host disease (GVHD) in children, adolescents, and young adults. (clinicaltrials.gov)
  • Immunomagnetic selection of HLA-mismatched CD34+ progenitor cells has demonstrated high levels of T cell depletion and successful engraftment in adult and pediatric patients with the malignant and nonmalignant disease. (clinicaltrials.gov)
  • Only patients with a typical, well-defined disease were included in the study. (asm.org)
  • Graft-versus-host disease (GVHD) is a condition that results from a reaction of transplanted donor T-lymphocytes against the body and organs of the patient receiving the transplanted cells. (clinicaltrials.gov)
  • This study is a clinical trial for patients diagnosed with a non-malignant disease who will receive a peripheral blood stem cell transplant. (clinicaltrials.gov)
  • Michael J. Sillers, MD, Director of the Alabama Nasal and Sinus Center in Birmingham, said that the surgery is considered unsuccessful if the patient has persistence, recurrence, or worsening of sinus symptoms or disease after sinus surgery. (enttoday.org)
  • FESS would be considered unsuccessful if after surgery, the patient still has symptoms that influence the quality of life and still has objective disease as documented by the exam or CT scan, said Stilianos Kountakis, MD, PhD, Vice Chair of Otolaryngology at Medical College of Georgia in Augusta, where he is Co-Director of Rhinology-Sinus Surgery. (enttoday.org)
  • Others may have a genetic predisposition to sinus disease, as in patients with asthma. (enttoday.org)
  • Explain to patients that they are having surgery because their disease can't be managed with medications and that the goal of surgery is to make the disease manageable with medications again. (enttoday.org)
  • Helping patients understand the nature of [sinus] disease is a critical component of preventing their disappointment in FESS, said Brent Senior, MD, Chief of Rhinology, Allergy, and Sinus Surgery at the University of North Carolina in Chapel Hill. (enttoday.org)
  • Our patient population in this newer study consisted of patients imaged for reasons other than stroke or cerebrovascular disease, which was thought more reflective of the disease-free general population. (ajnr.org)
  • For the second objective, we studied the 333 patients with: (a) coronary artery disease (CAD), (b) properly evaluable SNA and (c) complete clinical history available. (nih.gov)
  • In 51 (15.3%) a SNA disease was found, 41.2% of them had a positive SVA history, mainly atrial fibrillation (AF), whereas only 7.4% of patients with a positive history of SVA could be found in the non-SNA diseased. (nih.gov)
  • We undertook a four-stage Delphi consensus project among a panel of 47 international experts in prostate FT. Data on three main domains (role of biopsy/imaging, disease and patient factors) were collected in three iterative rounds of online questionnaires and feedback. (ovid.com)
  • Thus, patients with clinically silent or asymptomatic electrical instability or with coronary artery/ischemic heart disease without angina pectoris may not enter the health care system before an episode of sudden death. (springer.com)
  • Sensitivity, specificity and predictive accuracy of radionuclide cineangiography during exercise in patients with coronary artery disease, Circulation 60:572-580 (1979). (springer.com)
  • In case of concordant evidence of extra-hepatic disease the patient is considered to be non-resectable. (knowcancer.com)
  • Over the past decade several clinical trials have demonstrated that proper patient selection are important for the success of accelerated partial breast irradiation. (stanford.edu)
  • Celgene has secured a nonexclusive license to use Aprinoia Therapeutics' lead candidate, the Phase I tau positron emission tomography (PET) imaging tracer APN-1607, to support patient selection and efficacy evaluation in its global clinical trials, Aprinoia said today, through a deal whose value was not disclosed. (genengnews.com)
  • Prediction tools can provide a high impact to better select the patients enrolled in Alzheimer's clinical trials, increasing the chance of success,' said Pr. (prnewswire.com)
  • Our tool offers a way for pharmaceutical companies to optimize patient recruitment for clinical trials, by prioritizing the selection of patients who are more likely to show a cognitive change within the trial duration. (prnewswire.com)
  • The effect of endoscopic lung volume reduction in patients with a homogeneous distribution of emphysema is still unclear and this subgroup should be treated only in clinical trials. (dovepress.com)
  • He underlined the need for physicians to actively enroll patients in clinical trials. (uroweb.org)
  • Physicians should make every effort to enroll patients on clinical trials that address critical issues. (uroweb.org)
  • Our analysis of patient selection strategies indicates that optimal trial design for early-stage trials should be based on multiple factors, including prevalence and heterogeneity of target expression among intent-to-treat patients, as well as biological factors influencing expression of cell surface and soluble target. (aacrjournals.org)
  • However, implementation of biomarker-driven trials where patients are selected on the basis of tumor target expression can be challenging in early drug development due to multiple factors including: tumor heterogeneity, assay sensitivity, and accuracy, potential changes in target expression after multiple therapies, and difficulties in determining threshold levels for target expression that correlate with efficacy ( 3 ). (aacrjournals.org)
  • To date, early-phase trials with ADCs have focused primarily on target expression as a patient selection strategy, either by guiding prospective enrollment, or retrospectively evaluating biomarkers associated with clinical benefit. (aacrjournals.org)
  • To determine whether a relationship exists between target expression and clinical activity, we comprehensively examined patient selection strategies that have been used in 47 phase I and II clinical trials of ADCs. (aacrjournals.org)
  • Early-phase studies were defined as all phase I and II clinical trials conducted with ADCs in both hematologic and solid tumor patients. (aacrjournals.org)
  • These patients may have entered the trials too late for potential benefit of PTRAS. (onlinejacc.org)
  • Patient recruitment includes a variety of services-typically performed by a Patient Recruitment Service Provider-to increase enrollment into clinical trials. (wikipedia.org)
  • Improving patient recruitment rates offers pharmaceutical and medical device companies one of the biggest opportunities to accelerate the pace of clinical trials - making it possible to reduce time to market. (wikipedia.org)
  • As the number of patients needed for clinical trials rises - as safety and regulatory issues drive trends toward larger and longer trials - the demand for patient recruitment services grows. (wikipedia.org)
  • The patient recruitment sector has experienced rapid growth in recent years, particularly in response to increasing number of global clinical trials. (wikipedia.org)
  • Active surveillance for prostate cancer: patient selection and management L. Klotz, MD is a paper published in last month's Current Oncology. (healingwell.com)
  • Results- The study included 134 patients operated on between 1999 and 2001. (ahajournals.org)
  • FDA said the latest interim results indicate a lower survival rate for the subgroup of post-approval study patients who would not have qualified for the premarket clinical studies compared to the premarket clinical study survival rate. (medworm.com)
  • Following these results, researchers began to consider patient selection for the targeted therapies based on clinical features, such as sex and smoking history. (cancernetwork.com)
  • The results of the study provide new data to advance patient-selection processes for outpatient surgery. (nih.gov)
  • The results thus obtained would be used as guidelines during selection of teeth, arrangement of teeth among edentulous patients of Saudi Arabian population for esthetically pleasing fixed and removable dental prosthesis. (hausarbeiten.de)
  • However, we briefly state that such discordant findings could well be explained in the context of "spectrum bias," implying that the performance of a diagnostic test may vary between different clinical settings due to changes in the patient case mix, therefore affecting the reproducibility of study results. (ajnr.org)
  • Results: There were 2300 patients included. (diva-portal.org)
  • The results suggest that a variance in response to clopidogrel is unlikely to be clinically significant even in larger cohorts of patients. (bl.uk)
  • Is it possible to improve long-term results of laparoscopic adjustable gastric banding with appropriate patient selection? (termedia.pl)
  • Orłowski M, Janik M, Franczak P, Frask A, Michalik M. Is it possible to improve long-term results of laparoscopic adjustable gastric banding with appropriate patient selection? (termedia.pl)
  • Promising early results and the possibility of complete reversal were responsible for great patient interest in this procedure. (termedia.pl)
  • Some prospective studies that select patients based on clinical features have been conducted, but the results are not yet available. (aacrjournals.org)
  • Although hospitals are always looking to reduce costs while continuing to improve patient care, these survey results show the importance of having an effective infection control program. (suntechmed.com)
  • Results: One hundred and ninety-three of 257 (75%) patients were SHARP eligible. (eur.nl)
  • For example, in breast cancer survivors, evidence indicates that recruiting via letters or at the oncologist's office results in the recruitment of similar patients. (wikipedia.org)
  • A review on adherence management in patients on oral cancer therapies. (semanticscholar.org)
  • Drug developers are still searching for effective therapies for neuropathic pain conditions to address this underserved patient population. (premier-research.com)
  • Finally, even when risk and likely mechanism of death both are identified in an individual patient, current pharmacological and surgical therapies offer incomplete protection against the lethal event. (springer.com)
  • And both of these changes-less invasive alternatives and new medical adjuncts-have influenced which patients undergo, and garner benefit from carotid revascularization [ 13 , 14 ]. (hindawi.com)
  • Patients generally do not undergo currently available testing procedures (which are at best not totally predictive) until potential risk is heralded by some clinical event. (springer.com)
  • Endoscopic bronchial valve placement with complete occlusion of one lobe in patients with heterogeneous emphysema is the preferred technique because of its reversibility. (dovepress.com)
  • Problem Definition: We study how to admit and schedule heterogeneous patients by using simple, interpretable, yet effective policies when capacity is scarce, no-show behavior is patient- and time-dependent, and overtime is costly. (ssrn.com)
  • Instead, our prevailing approaches to matching patients with physicians remain largely agnostic to variations in patient preferences, tethered to the traditions of peer recommendation and reputation-based referral. (ajmc.com)
  • As accountable care, value-based purchasing, and other new models of care delivery and financing intensify our focus on patient-centered care and longitudinal relationships with physicians, it is necessary to improve the healthcare system's capacity to match patients with physicians who fit their specific needs, preferences, and values. (ajmc.com)
  • In this perspective, we draw on the insights from research into patient preferences to propose a framework for understanding and organizing the information necessary to successfully match patients and physicians. (ajmc.com)
  • Specifically, we outline 5 factors that should be considered when matching patients with physicians, and provide examples of the information and attributes that are important to consider within each factor. (ajmc.com)
  • Performed a demonstration study among 32 health care providers (9 physicians and 23 clinical staff) and 105 patients in an inner city primary care practice where patients recorded their preferences concerning who could access what information in their electronic health records, and then implemented those preferences during a 6-month real-world study in Eskenazi Health. (clinicaltrials.gov)
  • It is critical for both physicians and patients to understand the benefits as well as the potential risks of treating MS with natalizumab. (ajmc.com)
  • Population research: Discovering the motivational drivers of target patient populations is commonly gathered through focus groups, and may involve caregivers and physicians. (wikipedia.org)
  • Comiter C. Surgery for postprostatectomy incontinence: which procedure for which patient? (springer.com)
  • But as the number of successful face transplant surgeries inches ever higher, medical ethicists already are discussing how to make decisions on if and when patients should be eligible for the costly and complex procedure that some say represents the ultimate gift from a deceased donor's family. (go.com)
  • The reliability of that selection policy has been assessed by reviewing the status of 25 patients in whom pacemakers were not inserted after initial evaluation because symptoms were judged at that time insufficient to justify the procedure. (annals.org)
  • Patients undergoing spinal fusion surgery who are treated with methadone during the procedure require significantly less intravenous and oral opioids to manage postoperative pain, reports a new study published in the May issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA). (brightsurf.com)
  • The new study offers additional insights on the COAPT trial, which investigated the use of a procedure called transcatheter mitral valve repair (TMVR) in patients with secondary mitral regurgitation, a condition where the mitral valve does not close properly due to problems with the heart's pumping chambers. (acc.org)
  • Patients classified as non responders to clopidogrel had no difference in emboli counts before and after the stenting procedure (p = 0.24). (bl.uk)
  • Immediately prior to the procedure, patients will be hydrated with 500 ml of water. (knowcancer.com)
  • Lung function parameters and comorbidities of the patient, as well as the extent and distribution of the emphysema are factors to be considered when choosing the patient and the intervention. (dovepress.com)
  • While we learned that patients with higher pulmonary hypertension are at higher risk after they receive the MitraClip, they still do better than if they would not have had the intervention done. (acc.org)
  • BACKGROUND: The authors hypothesized that patients with metastatic colorectal cancer (mCRC) who had tumors with low thymidylate synthase (TS-L) expression would have a higher response rate to combined 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) plus bevacizumab (FOLFOX/Bev) than those with high TS (TS-H) expression and that combined irinotecan and oxaliplatin (IROX) plus bevacizumab (IROX/Bev) would be more effective than FOLFOX/Bev in those with TS-H tumors. (healthpartners.com)
  • Patients who had TS-L tumors received FOLFOX/Bev, and those who had TS-H tumors were randomly assigned to receive either FOLFOX/Bev or IROX/Bev. (healthpartners.com)
  • Patients with TS-H tumors did not benefit more from IROX/Bev than from FOLFOX/Bev. (healthpartners.com)
  • Following calibration on only a small number of cell lines or cohorts of patient data, they provide a reliable assessment of signaling pathway activity in tumors of different tissue origin. (eur.nl)
  • The case highlights the unresolved issue of screening for subclavian stenoses in patients being considered for revascularization with arterial Y-grafting. (medworm.com)
  • In a contemporary series of patients with CAD, 28.8% had incomplete revascularization. (cryolife.com)
  • In all, some 100,000 - 200,000 patients per year may be eligible for new revascularization techniques. (cryolife.com)
  • To help translate COAPT's findings into practical guidance for clinical decisions, the new study details how echocardiography can be used to diagnose secondary mitral regurgitation, along with how the researchers used a multi-parametric algorithm adapted from the American Society of Echocardiography and ACC guidelines to determine which patients were eligible to participate in the study and track the valve's function over the course of two years. (acc.org)
  • This is an agent that's clearly active, clearly has efficacy, is approved for these patients, and can be well tolerated as a single agent. (onclive.com)
  • The system compares medication regimens side-by-side, predicting efficacy, risk of side effects, and costs, in a way that is easy for both clinicians and patients to understand. (hitachi.com)
  • This course will outline and describe three important topics clinicians should consider when helping patients who present with bothersome tinnitus: 1) a patient-centered approach that includes consideration for self-efficacy, 2) commonalities and efficacy of tinnitus management protocols and 3) the importance of amplification in mitigating tinnitus perception. (audiologyonline.com)
  • After this course, participants will be able to explain how to implement a patient-centered approach to initial counseling for patients presenting with a primary complaint of tinnitus, considering the principles of self-efficacy. (audiologyonline.com)
  • After this course, participants will be able to describe to patients the commonalities between and efficacy of various tinnitus management protocols. (audiologyonline.com)
  • However, there have been no thorough reviews of the various selection strategies and whether they correlate with clinical efficacy. (aacrjournals.org)
  • Use of lung transplantation survival models to refine patient selection in cystic fibrosis. (nih.gov)
  • Lung transplantation in cystic fibrosis may improve survival for patients with low 5-year predicted survival. (nih.gov)
  • To estimate the survival benefit of transplantation for patients affected by identified variables, we compared Kaplan-Meier survival curves of transplanted and control patients stratified by 5-year predicted survival. (nih.gov)
  • Patients with arthropathy, B. cepacia infection, or younger age derive no aggregate survival benefit and must appraise carefully the high risk of decreased post-transplantation survival. (nih.gov)
  • Adult patients with low 5-year predicted survival without B. cepacia infection should receive priority for lung transplantation. (nih.gov)
  • For the subgroup of patients who would not have qualified for the premarket studies, the survival rate was 10.7% (3 out of 28 patients). (medworm.com)
  • Surgery offers selected patients - per Desktop 3 as well as SOC 1 - an overall survival advantage but it's really important to make sure validated tools are employed for patient selection. (healio.com)
  • Meta-analysis reveals only a modest 6% improvement in five-year survival and only approximately 20-25% of unselected patients benefit. (uroweb.org)
  • Moreover, not all patients with MIBC seem to need NAC to potentiate survival as patients with organ-confined bladder cancer (≤ pT2) who make up about 50% of those in contemporary surgical series have an excellent survival following cystectomy, with over 80% cured by cystectomy alone," he explained. (uroweb.org)
  • In 2018, COAPT researchers reported that patients undergoing TMVR with the MitraClip device had significantly better rates of survival at two years compared to those receiving standard medications alone. (acc.org)
  • Secondary mitral valve regurgitation frequently coexists with heart failure, worsens patients' symptoms and affects their quality of life and survival. (acc.org)
  • The primary endpoint was progression-free survival, assessed by an independent radiology review committee in patients with PD-L1 in 5% or more tumour cells . (medicalxpress.com)
  • The Corus CAD test is intended for use in patients who present with stable symptoms suggestive of obstructive CAD. (cardiodx.com)
  • I appreciate the fact that Dr. Sherlock was very clear that she wasn't as educated about the topic before her work in 2006 and explained what we SHOULD be asking patients when they present with tinnitus symptoms. (audiologyonline.com)
  • M. Ericsson, A. Granath, P. Ohlsen, T. Sodermark and U. Volpe, Arrhythmias and symptoms during treadmill testing three weeks after myocardial infarction in 100 patients, Brit. (springer.com)
  • The dental profession is committed to delivering the highest quality of care to each of its individual patients and applying advancements in technology and science to continually improve the oral health status of the U.S. population. (fda.gov)
  • Also, among Saudi population, there is lack of research evidence pertaining to factors related to artificial tooth selection for edentulous patients. (hausarbeiten.de)
  • that "the 'sick patients' sample does not appear to be reliable in this article because this might exclude a too-large population of patients" is irrelevant. (asm.org)
  • In that particular regard, we would like to note several prominent differences from ours in their study, most notably the method of selecting their patient population. (ajnr.org)
  • 3 Hence, we think that the current study deviates from this belief by incorporating high-risk patients as the selected subject population. (ajnr.org)
  • We feel confident that Horizon's expertise will provide an effective and efficient way of defining the most responsive cancer patient population. (horizondiscovery.com)
  • This major gap within the literature limits the ability to generalise this evidence to the target patient population. (bmj.com)
  • These recommendations will enhance the validity of research conducted in this clinical population with the end goal of bringing the research evidence to the clinician and patient. (bmj.com)
  • Hitachi and University of Utah Health (U of U Health), a leading institution in electronic health records and interoperable clinical information systems research, today announced the joint development of a decision support system that allows clinicians and patients to choose from available pharmaceutical options for treating type-2 diabetes mellitus. (hitachi.com)
  • All patient groups were homogeneous in median age and gender. (nih.gov)
  • The investigators hope that this demonstration and feasibility project will lead to more extensive prospective evaluations of patient control of access to their health records and other tools for enhancing patient control over access to their health records. (clinicaltrials.gov)
  • D. H. Miller, J. S. Borer, P. D. Kligfield, D. L. Hayes and E. Whitacre, Independence of exercise-induced electrocardiographic ischemia and left ventricular function in patients with recent myocardial infarction, Clin. (springer.com)
  • There are no multicenter clinical data guiding patient selection for outpatient surgery. (nih.gov)
  • Using this computer-based matching system, prospective hearing aid users, who might be starting from ground zero, have a handy, impartial tool to assist in the hearing aid selection process. (hearinghealthmatters.org)
  • What is surprising though is that based on a survey conducted in July 2011 , prospective patients are becoming increasingly aware of a hospital's ability to protect their patients from HAIs and are using this information as a major factor in determining where they seek care. (suntechmed.com)
  • We report the establishment of tumor organoid cultures from 20 consecutive colorectal carcinoma (CRC) patients. (medgadget.com)
  • Researchers with a company that makes antibody-based immunotherapy drugs are calling for the development of new patient selection strategies for people with malignant mesothelioma and other intractable cancers. (prweb.com)
  • If we are going to replace it with immunotherapy, we need to be confident that we are identifying the patients who will derive greater benefit. (medicalxpress.com)
  • Bladder leak point pressure: the measure for sphincterotomy success in spinal cord injured patients with external detrusor-sphincter dyssynergia. (springer.com)
  • As you move into clinical trial execution, Parexel's ForeSite TM methodology helps meet the competing needs and logistics of sponsors, investigators, and patients. (parexel.com)
  • The software computes a cognitive decline risk score that can be used to enrich patient selection strategy with the aim to increase clinical trial success probability. (prnewswire.com)
  • Patient enrollment is the most time-consuming aspect of the clinical trial process. (wikipedia.org)
  • The leading cause of missed clinical trial deadlines is patient recruitment, taking up to 30 percent of the clinical timeline. (wikipedia.org)
  • The goal of patient recruitment is to raise awareness of clinical trial opportunities and to encourage enrollment. (wikipedia.org)
  • Matulonis detailed Desktop 3, which sought to show the benefit of a predictive score to identify patients who had a complete response in surgery and might benefit from another surgery at the time of relapse, specifically platinum-sensitive relapse. (healio.com)
  • Bex, meanwhile, stressed in his lecture that patients selection will prove crucial. (uroweb.org)
  • 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. (springer.com)
  • How to select patients for antireflux surgery? (bmj.com)
  • Background and Purpose- Risk-factor modeling has been proposed to identify patients with carotid stenosis who will most benefit from surgery. (ahajournals.org)
  • This means that preventive surgery remains without benefit for at least 4 of 5 operated patients. (ahajournals.org)
  • They must consider, against the background of medical alternatives, the physiologic insult that surgery entails in these elderly patients, who often carry with them significant comorbidity burdens [ 7 - 10 ]. (hindawi.com)
  • Accurate estimates of benefits and risks of aortocoronary bypass surgery are necessary in the management of specific patients. (ahajournals.org)
  • These patients were divided into two groups according to their date of surgery (before and after July 2002). (nih.gov)
  • This review summarizes the benign and malignant illnesses that are treated with pancreas operations, and innovations and improvements in pancreatic surgery and perioperative care, and describes the careful selection process for patients who would benefit from an operation. (dovepress.com)
  • they actually do worse than patients who are randomized to no surgery," she said. (healio.com)
  • therefore, endoscopic coil placement, polymeric lung volume reduction, or bronchoscopic thermal vapor ablation as well as lung volume reduction surgery can be used for treating patients with incomplete fissures. (dovepress.com)
  • However, some patients are ineligible for surgery due to poor general condition or tumor extent and location ( 8 ). (frontiersin.org)
  • The success of functional endoscopic sinus surgery (FESS) often depends on patient selection and expectations, according to several experts. (enttoday.org)
  • Patients with allergic fungal rhinosinusitis require surgery to remove the fungal debris, and they require aggressive medical management afterward. (enttoday.org)
  • The presentation will focus on important next steps in the development of cancer immunotherapies, including understanding mechanisms of resistance to anti-PD-1/PD-L1 treatments, identifying optimal combinations, and identifying individual patient predictors of response or lack of response. (biomarkerworldcongress.com)
  • Validation by independent institutions performing carotid endarterectomy is necessary to determine the applicability of such models to the individual patient. (ahajournals.org)
  • The statistical data were gathered from 2060 ECST patients with 0% to 69% carotid stenosis. (ahajournals.org)
  • It has recently been used to select patients with carotid stenosis for endovascular angioplasty and stenting, although this may be questionable. (ahajournals.org)
  • A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs. (semanticscholar.org)
  • Transplantation never improves survivorship for pediatric patients. (nih.gov)