Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Systematic discussions and teaching relating to patient care.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Elements of limited time intervals, contributing to particular results or situations.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Prenatal interventions to correct fetal anomalies or treat FETAL DISEASES in utero. Fetal therapies include several major areas, such as open surgery; FETOSCOPY; pharmacological therapy; INTRAUTERINE TRANSFUSION; STEM CELL TRANSPLANTATION; and GENETIC THERAPY.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Genotypic differences observed among individuals in a population.
Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The introduction of error due to systematic differences in the characteristics between those selected and those not selected for a given study. In sampling bias, error is the result of failure to ensure that all members of the reference population have a known chance of selection in the sample.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Surgical insertion of synthetic material to repair injured or diseased heart valves.
Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Procedures that avoid use of open, invasive surgery in favor of closed or local surgery. These generally involve use of laparoscopic devices and remote-control manipulation of instruments with indirect observation of the surgical field through an endoscope or similar device.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The plan and delineation of prostheses in general or a specific prosthesis.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Tumors or cancer of the LIVER.
The restoration of the sequential order of contraction and relaxation of the HEART ATRIA and HEART VENTRICLES by atrio-biventricular pacing.
A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.
The discipline studying genetic composition of populations and effects of factors such as GENETIC SELECTION, population size, MUTATION, migration, and GENETIC DRIFT on the frequencies of various GENOTYPES and PHENOTYPES using a variety of GENETIC TECHNIQUES.
The return of a sign, symptom, or disease after a remission.
Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.
The use of freezing as a special surgical technique to destroy or excise tissue.
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
The relationships of groups of organisms as reflected by their genetic makeup.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.
The excision of the thickened, atheromatous tunica intima of a carotid artery.
Surgical insertion of a prosthesis.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Excision of all or part of the liver. (Dorland, 28th ed)
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
The transference of a part of or an entire liver from one human or animal to another.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Methods of creating machines and devices.
Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Tumors or cancer of the LUNG.
Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.
Surgery performed on the nervous system or its parts.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
Surgical reconstruction of a joint to relieve pain or restore motion.
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children.
Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
The excision of lung tissue including partial or total lung lobectomy.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Developmental abnormalities in any portion of the ATRIAL SEPTUM resulting in abnormal communications between the two upper chambers of the heart. Classification of atrial septal defects is based on location of the communication and types of incomplete fusion of atrial septa with the ENDOCARDIAL CUSHIONS in the fetal heart. They include ostium primum, ostium secundum, sinus venosus, and coronary sinus defects.
Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.
Complete or partial surgical removal of the prostate. Three primary approaches are commonly employed: suprapubic - removal through an incision above the pubis and through the urinary bladder; retropubic - as for suprapubic but without entering the urinary bladder; and transurethral (TRANSURETHRAL RESECTION OF PROSTATE).
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
The selection or choice of sexual partner in animals. Often this reproductive preference is based on traits in the potential mate, such as coloration, size, or behavioral boldness. If the chosen ones are genetically different from the rejected ones, then NATURAL SELECTION is occurring.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
A CATHETER-delivered implant used for closing abnormal holes in the cardiovascular system, especially HEART SEPTAL DEFECTS; or passageways intentionally made during cardiovascular surgical procedures.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
Surgery performed on the heart.
A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Operative procedures for the treatment of vascular disorders.
Tumors or cancer of the human BREAST.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
A subspecialty of internal medicine concerned with the study of neoplasms.
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.
A malignant epithelial tumor with a glandular organization.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
The prediction or projection of the nature of future problems or existing conditions based upon the extrapolation or interpretation of existing scientific data or by the application of scientific methodology.
Antibodies produced by a single clone of cells.
Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
Application of electric current in treatment without the generation of perceptible heat. It includes electric stimulation of nerves or muscles, passage of current into the body, or use of interrupted current of low intensity to raise the threshold of the skin to pain.
The fluctuation of the ALLELE FREQUENCY from one generation to the next.
The use of photothermal effects of LASERS to coagulate, incise, vaporize, resect, dissect, or resurface tissue.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Tumors or cancer of the PROSTATE.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The condition of weighing two, three, or more times the ideal weight, so called because it is associated with many serious and life-threatening disorders. In the BODY MASS INDEX, morbid obesity is defined as having a BMI greater than 40.0 kg/m2.
Changes in biological features that help an organism cope with its ENVIRONMENT. These changes include physiological (ADAPTATION, PHYSIOLOGICAL), phenotypic and genetic changes.
Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.
Tumors or cancer of the PERITONEUM.
Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.
The period of confinement of a patient to a hospital or other health facility.
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.
The mating of plants or non-human animals which are closely related genetically.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
The total process by which organisms produce offspring. (Stedman, 25th ed)
Radiography of blood vessels after injection of a contrast medium.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Computer-based representation of physical systems and phenomena such as chemical processes.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Pathological processes of the LIVER.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Agents that inhibit PROTEIN KINASES.
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
Sexual activities of animals.
Functions constructed from a statistical model and a set of observed data which give the probability of that data for various values of the unknown model parameters. Those parameter values that maximize the probability are the maximum likelihood estimates of the parameters.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Disease having a short and relatively severe course.
Methods for controlling genetic SEX of offspring.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
Transplantation of an individual's own tissue from one site to another site.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Tumors or cancer of the RECTUM.
The capability of an organism to survive and reproduce. The phenotypic expression of the genotype in a particular environment determines how genetically fit an organism will be.
A set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (CODON, TERMINATOR). Most codons are universal, but some organisms do not produce the transfer RNAs (RNA, TRANSFER) complementary to all codons. These codons are referred to as unassigned codons (CODONS, NONSENSE).
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.
The transference of a heart from one human or animal to another.
Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
A characteristic showing quantitative inheritance such as SKIN PIGMENTATION in humans. (From A Dictionary of Genetics, 4th ed)
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Replacement of the knee joint.
Surgical excision of one or more lymph nodes. Its most common use is in cancer surgery. (From Dorland, 28th ed, p966)
The total amount of radiation absorbed by tissues as a result of radiotherapy.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.

Geographic, demographic, and socioeconomic variations in the investigation and management of coronary heart disease in Scotland. (1/7350)

OBJECTIVE: To determine whether age, sex, level of deprivation, and area of residence affect the likelihood of investigation and treatment of patients with coronary heart disease. DESIGN, PATIENTS, AND INTERVENTIONS: Routine discharge data were used to identify patients admitted with acute myocardial infarction (AMI) between 1991 and 1993 inclusive. Record linkage provided the proportion undergoing angiography, percutaneous transluminal coronary angioplasty (PTCA), and coronary artery bypass grafting (CABG) over the following two years. Multiple logistic regression analysis was used to determine whether age, sex, deprivation, and area of residence were independently associated with progression to investigation and revascularisation. SETTING: Mainland Scotland 1991 to 1995 inclusive. MAIN OUTCOME MEASURES: Two year incidence of angiography, PTCA, and CABG. Results-36 838 patients were admitted with AMI. 4831 (13%) underwent angiography, 587 (2%) PTCA, and 1825 (5%) CABG. Women were significantly less likely to undergo angiography (p < 0.001) and CABG (p < 0.001) but more likely to undergo PTCA (p < 0.05). Older patients were less likely to undergo all three procedures (p < 0.001). Socioeconomic deprivation was associated with a reduced likelihood of both angiography and CABG (p < 0.001). There were significant geographic variations in all three modalities (p < 0.001). CONCLUSION: Variations in investigation and management were demonstrated by age, sex, geography, and socioeconomic deprivation. These are unlikely to be accounted for by differences in need; differences in clinical practice are, therefore, likely.  (+info)

Early death during chemotherapy in patients with small-cell lung cancer: derivation of a prognostic index for toxic death and progression. (2/7350)

Based on an increased frequency of early death (death within the first treatment cycle) in our two latest randomized trials of combination chemotherapy in small-cell lung cancer (SCLC), we wanted to identify patients at risk of early non-toxic death (ENTD) and early toxic death (ETD). Data were stored in a database and logistic regression analyses were performed to identify predictive factors for early death. During the first cycle, 118 out of 937 patients (12.6%) died. In 38 patients (4%), the cause of death was sepsis. Significant risk factors were age, performance status (PS), lactate dehydrogenase (LDH) and treatment with epipodophyllotoxins and platinum in the first cycle (EP). Risk factors for ENTD were age, PS and LDH. Extensive stage had a hazard ratio of 1.9 (P = 0.07). Risk factors for ETD were EP, PS and LDH, whereas age and stage were not. For EP, the hazard ratio was as high as 6.7 (P = 0.0001). We introduced a simple prognostic algorithm including performance status, LDH and age. Using a prognostic algorithm to exclude poor-risk patients from trials, we could minimize early death, improve long-term survival and increase the survival differences between different regimens. We suggest that other groups evaluate our algorithm and exclude poor prognosis patients from trials of dose intensification.  (+info)

Peritoneal cytology in the surgical evaluation of gastric carcinoma. (3/7350)

Many patients undergoing surgery for gastric carcinoma will develop peritoneal metastases. A method to identify those patients at risk of peritoneal recurrence would help in the selection of patients for adjuvant therapy. Peritoneal cytology has received little attention in the West, but may prove a useful additional means of evaluating patients with gastric cancer. The aims of this study were to evaluate sampling techniques for peritoneal cytology in patients with gastric cancer, to assess the prognostic significance of free peritoneal malignant cells and to discover the effect of the operative procedure on dissemination of malignant cells. The study is based on 85 consecutive patients undergoing surgical treatment of gastric cancer and followed up for 2 years or until death. Peritoneal cytology samples were collected at laparoscopy, and at operation prior to resection by intraperitoneal lavage and serosal brushings. After resection, samples were taken by peritoneal lavage, imprint cytology of the resected specimen and post-operatively by peritoneal irrigation via a percutaneous catheter. Malignant cells were diagnosed by two independent microscopists. Preoperative peritoneal lavage yielded malignant cells in 16 out of 85 cases (19%). The yield of free malignant cells was increased by using serosal brushings (by four cases) and imprint cytology (by two cases); all of the cases had evidence of serosal penetration. One serosa-negative case exhibited positive cytology in the post-resection peritoneal specimen in which the preresection cytology specimen was negative. Survival was worse in the cytology-positive group (chi2 = 25.1; P< 0.0001). Among serosa-positive patients, survival was significantly reduced if cytology was positive, if cases yielded by brushings and imprint cytology were included (log-rank test = 8.44; 1 df, P = 0.004). In conclusion, free peritoneal malignant cells can be identified in patients with gastric cancer who have a poor prognosis; the yield can be increased with brushings and imprint cytology in addition to conventional peritoneal lavage. Evaluation of peritoneal cytology by these methods may have a role in the selection of patients with the poorest prognosis who may benefit most from adjuvant therapy.  (+info)

Profound variation in dihydropyrimidine dehydrogenase activity in human blood cells: major implications for the detection of partly deficient patients. (4/7350)

Dihydropyrimidine dehydrogenase (DPD) is responsible for the breakdown of the widely used antineoplastic agent 5-fluorouracil (5FU), thereby limiting the efficacy of the therapy. To identify patients suffering from a complete or partial DPD deficiency, the activity of DPD is usually determined in peripheral blood mononuclear cells (PBM cells). In this study, we demonstrated that the highest activity of DPD was found in monocytes followed by that of lymphocytes, granulocytes and platelets, whereas no significant activity of DPD could be detected in erythrocytes. The activity of DPD in PBM cells proved to be intermediate compared with the DPD activity observed in monocytes and lymphocytes. The mean percentage of monocytes in the PBM cells obtained from cancer patients proved to be significantly higher than that observed in PBM cells obtained from healthy volunteers. Moreover, a profound positive correlation was observed between the DPD activity of PBM cells and the percentage of monocytes, thus introducing a large inter- and intrapatient variability in the activity of DPD and hindering the detection of patients with a partial DPD deficiency.  (+info)

The effect of race and sex on physicians' recommendations for cardiac catheterization. (5/7350)

BACKGROUND: Epidemiologic studies have reported differences in the use of cardiovascular procedures according to the race and sex of the patient. Whether the differences stem from differences in the recommendations of physicians remains uncertain. METHODS: We developed a computerized survey instrument to assess physicians' recommendations for managing chest pain. Actors portrayed patients with particular characteristics in scripted interviews about their symptoms. A total of 720 physicians at two national meetings of organizations of primary care physicians participated in the survey. Each physician viewed a recorded interview and was given other data about a hypothetical patient. He or she then made recommendations about that patient's care. We used multivariate logistic-regression analysis to assess the effects of the race and sex of the patients on treatment recommendations, while controlling for the physicians' assessment of the probability of coronary artery disease as well as for the age of the patient, the level of coronary risk, the type of chest pain, and the results of an exercise stress test. RESULTS: The physicians' mean (+/-SD) estimates of the probability of coronary artery disease were lower for women (probability, 64.1+/-19.3 percent, vs. 69.2+/-18.2 percent for men; P<0.001), younger patients (63.8+/-19.5 percent for patients who were 55 years old, vs. 69.5+/-17.9 percent for patients who were 70 years old; P<0.001), and patients with nonanginal pain (58.3+/-19.0 percent, vs. 64.4+/-18.3 percent for patients with possible angina and 77.1+/-14.0 percent for those with definite angina; P=0.001). Logistic-regression analysis indicated that women (odds ratio, 0.60; 95 percent confidence interval, 0.4 to 0.9; P=0.02) and blacks (odds ratio, 0.60; 95 percent confidence interval, 0.4 to 0.9; P=0.02) were less likely to be referred for cardiac catheterization than men and whites, respectively. Analysis of race-sex interactions showed that black women were significantly less likely to be referred for catheterization than white men (odds ratio, 0.4; 95 percent confidence interval, 0.2 to 0.7; P=0.004). CONCLUSIONS: Our findings suggest that the race and sex of a patient independently influence how physicians manage chest pain.  (+info)

Studies on structural changes of the carotid arteries and the heart in asymptomatic renal transplant recipients. (6/7350)

BACKGROUND: The present study was designed to characterize early structural changes of large arteries in renal transplant recipients with no clinical evidence of cardiovascular disease and normal blood pressure values, and to analyse the relationship between arterial alterations and those of the heart. METHODS: Intima media thickness and atherosclerotic plaques of the carotid arteries as well as left ventricular geometry and function were examined in 35 asymtomatic renal transplant recipients and 29 age- and sex-matched healthy controls by high resolution B-mode ultrasound and by echocardiography. RESULTS: Intima-media thickness of the carotid arteries was significantly higher in renal transplant recipients (1.21+/-0.08 mm) than in healthy controls (0.74+/-0.04 mm) (P<0.001). Atherosclerotic plaques were found in the majority of renal transplant recipients (71% vs 14% in healthy controls, P<0.001). Left ventricular mass index was significantly increased in the group of renal transplant recipients (264+/-13 g, 146+/-7 g/m2) when compared with healthy controls (155+/-8 g, 83+/-4 g/m2) (P<0.001). Multiple regression analysis in renal transplant recipients showed that intima media thickness of the carotid arteries was significantly related to left ventricular mass index (P<0.02), but not to age, blood pressure, body mass index, serum creatinine, cholesterol and lipoprotein (a) levels. In the group of healthy controls, intima-media thickness of the carotid artery was related to age (P<0.002), but not to left ventricular mass index or the other independent variables. CONCLUSIONS: The present study documents pronounced intima-media thickening in asymptomatic renal transplant recipients. Atherosclerotic lesions are present in most renal transplant recipients with no clinical evidence of cardiovascular disease. We observed a parallelism between arterial wall thickening and left ventricular hypertrophy, although blood pressure levels were normal during haemodialysis therapy and after renal transplantation.  (+info)

Ruptured abdominal aortic aneurysms: selecting patients for surgery. (7/7350)

OBJECTIVES: Mortality from ruptured abdominal aortic aneurysm (RAAA) remains high. Despite this, withholding surgery on poor-prognosis patients with RAAA may create a difficult dilemma for the surgeon. Hardman et al. identified five independent, preoperative risk factors associated with mortality and proposed a model for preoperative patient selection. The aim of this study was to test the validity of the same model in an independent series of RAAA patients. METHODS: A consecutive series of patients undergoing surgery for RAAA was analysed retrospectively by case-note review. Thirty-day operative mortality and the presence of the five risk factors: age (> 76 years), creatinine (Cr) (> 190 mumol/l), haemoglobin (Hb) (< 9 g/dl), loss of consciousness and electrocardiographic (ECG) evidence of ischaemia were recorded for each patient. RESULTS: Complete data sets existed for 69 patients (mean age: 73 years, range: 38-86 years, male to female ratio: 6:1). Operative mortality was 43%. The cumulative effect of 0, 1 and 2 risk factors on mortality was 18%, 28% and 48%, respectively. All patients with three or more risk factors died (eight patients). CONCLUSIONS: These results lend support to the validity of the model. The potential to avoid surgery in patients with little or no chance of survival would spare unnecessary suffering, reduce operative mortality and enhance use of scarce resources.  (+info)

Repair of ruptured thoracoabdominal aortic aneurysm is worthwhile in selected cases. (8/7350)

INTRODUCTION: The risks and benefits of operating on patients with ruptured thoracoabdominal aortic aneurysm (TAAA) have not been defined. The aim of the present study is to report this unit's experience with operations performed for ruptured TAAA over a 10-year period. METHODS: Interrogation of a prospectively gathered computerised database. PATIENTS: Between 1 January 1983 and 30 June 1996, 188 consecutive patients with TAAA were operated on, of whom 23 (12%) were operated for rupture. RESULTS: There were nine survivors (40%). Patients whose preoperative systolic blood pressure remained above 100 mmHg were significantly more likely to survive (4/8 vs. 13/15, p = 0.03 by Fisher's exact test). Survival was also related to Crawford type: type I (two of three survived); II (none of six); III (two of six); and IV (five of eight). All non-type II, non-shocked patients survived operation. Survivors spent a median of 28 (range 10-66) postoperative days in hospital, of which a median of 6 (range 2-24) days were spent in the intensive care unit. Survivor morbidity comprised prolonged ventilation (> 5 days) (n = 3); tracheostomy (n = 1); and temporary haemofiltration (n = 2). No survivor developed paraplegia or required permanent dialysis. CONCLUSIONS: Patients in shock with a Crawford type II aneurysm have such a poor prognosis that intervention has to be questioned except in the most favourable of circumstances. However, patients with types I, III and IV who are not shocked on presentation can be salvaged and, where possible, should be transferred to a unit where appropriate expertise and facilities are available.  (+info)

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BACKGROUND: Randomized controlled trials (RCTs) are widely accepted as being the most efficient way of investigating the efficacy of psychological therapies. However, researchers conducting RCTs commonly report difficulties in recruiting an adequate sample within planned timescales. In an effort to overcome recruitment difficulties, researchers often are forced to expand their recruitment criteria or extend the recruitment phase, thus increasing costs and delaying publication of results. Research investigating the effectiveness of recruitment strategies is limited, and trials often fail to report sufficient details about the recruitment sources and resources utilized. PURPOSE: We examined the efficacy of strategies implemented during the Staying Well after Depression RCT in Oxford to recruit participants with a history of recurrent depression. METHODS: We describe eight recruitment methods utilized and two further sources not initiated by the research team and examine their efficacy in terms of (1) the
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Countries Compared by Education > High school enrolment rate. International Statistics at NationMaster.com, United Nations Educational, Scientific, and Cultural Organisation (UNESCO) Institute for Statistics. Aggregates compiled by NationMaster. Retrieved from http://www.nationmaster.com/country-info/group-stats/South-Asia/Education/High-school-enrolment-rate. Countries Compared by Education > High school enrolment rate. International Statistics at NationMaster.com, United Nations Educational, Scientific, and Cultural Organisation (UNESCO) Institute for Statistics. Aggregates compiled by NationMaster. 1990-2008. ,http://www.nationmaster.com/country-info/group-stats/South-Asia/Education/High-school-enrolment-rate,.. Countries Compared by Education > High school enrolment rate. International Statistics at NationMaster.com, United Nations Educational, Scientific, and Cultural Organisation (UNESCO) Institute for Statistics. Aggregates compiled by NationMaster., ...
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Total net enrolment rate, primary, gender parity index (GPI) in Guinea was reported at 0.82653 GPI in 2016, according to the World Bank collection of development indicators, compiled from officially recognized sources. Guinea - Total net enrolment rate, primary, gender parity index - actual values, historical data, forecasts and projections were sourced from the |a href=https://data.worldbank.org/ target=blank>World Bank|/a> on November of 2020.
Net enrolment rate, secondary, gender parity index (GPI) in Malawi was reported at 1.031 GPI in 2018, according to the World Bank collection of development indicators, compiled from officially recognized sources. Malawi - Net enrolment rate, secondary, gender parity index - actual values, historical data, forecasts and projections were sourced from the |a href=https://data.worldbank.org/ target=blank>World Bank|/a> on October of 2020.
Background Recruitment of participants into long-term community-based lifestyle intervention trials, particularly adults with a chronic disease, is often slow and challenging. Currently there is limited data on successful recruitment strategies suitable for older adults with type 2 diabetes into community-based exercise and nutrition programs, and no information on cost estimates associated with such recruitment. The aim of this report is to describe the recruitment strategies used and the success of each approach in recruiting older adults with type 2 diabetes into a 6-month community-based exercise and nutritional supplementation randomised controlled trial (RCT). A secondary aim is to assess the costs associated with the recruitment methods used. Methods The Resistance Exercise, Vitamin D and Muscle Protein Intervention Trial (REVAMP-IT) for type 2 diabetes is a 24-week RCT targeting 202 adults with type 2 diabetes which is designed to evaluate whether post-exercise ingestion of a whey- ...
Patient recruitment and up-front enrollment planning are critical to drug development programs. Patient recruitment, if not adequately planned for, can extend your development timeline by a number of years. Retention of patients throughout the life of a clinical trial is essential in order to have complete data sets for your analysis and subsequent filings. In order to optimize both, you have to have a plan and it should take into account all stakeholders from senior management at the sponsor company and the CRO partners, to the sites and investigators and study volunteers. Cambridge Healthtech Institutes Tenth Annual Enrollment Planning and Patient Recruitment conference will cover the topics one should consider when drafting and strategically implementing a patient recruitment plan for a clinical development program.. ,p justify;\=,. ...
Journal of Medical Internet Research - International Scientific Journal for Medical Research, Information and Communication on the Internet
Weve all been there as recruiters. We have a new requisition, and now its time to get additional information from the hiring manager so we can write a compelling posting and do a great job on this search.. It would seem intuitively obviously the better the information up front, the more successful the entire search will be. Yet so many times the hiring manager will not spend the time it takes to give the recruiter what they need. Even worse, letting the hiring manager duck the upfront meeting may be setting the stage for how the entire search is going to be.. Im not in favor of any bashing of hiring managers. If they arent working with you in the way you feel they should, lets change that. The amazing thing is that when you make some simple changes, you will change the relationship with your hiring managers.. As recruiters, we could easily (and legitimately) say It shouldnt be necessary for me to make a business case about why the hiring manager should spend time with me at the beginning ...
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Difference Between Staffing Agency and Executive Recruiter Agency Staffing Agency vs Executive Recruiter Agency Executive recruiter agencies, or headhunters, and staffing agencies are agencies which work as an intermediary between the employers and the employees. Both agencies have a similar framework, but their functions are slightly different from each other. The primary goal of both of these agencies is to match the requirements […]
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Defining a sound strategy for patient recruitment is the primary theme of this, the tenth book in an evolving series of pragmatic texts written for the clinical trials professional. Because patient recruitment problems are the most important reason for the failure of clinical trials, a strong need exists for a source that gathers numerous ideas for patient recruitment. The authors provide examples of letters, brochures, announcements, and campaigns that can be sculpted to reach intended study populations. Another strength is the checklist-oriented tables and study-specific figures that are based on current clinical trials ...
The University of Rochester Medical Center is actively engaged in clinical research with potential to improve the health of people and the communities within which they reside. The Clinical Trial Enrollment Unit of the Clinical Cardiovascular Research Center provides resources necessary to support efficient and effective study enrollment using strategic planning and bioinformatics-based tools. The unit works closely with the University of Rochester Clinical and Translational Sciences Center (UR CTSI) to leverage data driven cohort-discovery, collaborator-investigator identification and subject recruitment and retention. Our team includes health subjects coordinators and research finance specialists with diverse experience in clinical care and research involving all aspects of cardiovascular care. Our expertise includes:. ...
1995 - 2015: Physician Recruiter, Disability Consultant, Layton Disability Consultants (LDC). Jan 2014 - 2015: Independent Physician Recruiter, Dr Access Group. 1995 - 2008: Disability Management Consultant, Doctor Experts, Inc. 1992 - 1995: Director of Development, Medical Consultants Northwest. 1988 - 1992: Regional Manager, Lumbermens Underwriting. 1985 - 1988: Senior Examiner, State Accident Insurance Fund. - Smyrna, TN
Parity Professionals, the recruitment consultancy that specialises in Professionals Services and IT recruitment, features in the Recruiter Hot 100 List again this year coming in 59, based on financial performance for year ending 31 March 2016 The Recruiter Hot 100, now in its 11th year, through ...
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Recruiters are rarely proud of what they do. Most do it solely because the money can be great. It is no surprise that depression among recruiters is common, and the high level seems to be unique to…
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Background. The study was set up to assess the effect of recruitment methods on participation rate, response bias and cardiovascular risk factor estimates. Methods. Two random samples of men and women in Halifax County aged 25-74 were drawn from the same sampling frame. Their respective sizes were 1007 NSHHS and 3036 MONICA people. Recruitment...
Fear, dubiety, and melancholy are the leading sensations surrounding the entire human race in the new decade. But with the invasion of new trials and
a. By submitting your Profile to us, you grant Big Couch a worldwide, non-exclusive, royalty-free, transferable, sub-licensable license to use, reproduce, adapt, distribute and publish the Profile on the Website and to allow the Recruiters and Producers to use your Profile for the purpose of filling their Postings.. 4. Your relationship with Big Couch. a. By becoming a Registered Member you will be allowed to view and apply for Producer Jobs and apply for Recruiter Jobs that are distributed to you by us. The Postings are offered by Recruiters and Producers, not by Big Couch, and as such, any application made by you in response to a Posting is made to the Recruiter or Producer identified in the Posting.. b. Big Couch makes no representations about and does not guarantee the truth, accuracy or legitimacy of Postings. Once you have applied for a Posting, the relevant Recruiter or Producer will be made aware of your application and may contact you directly using the private message forum on the ...
Among the 155 interviews audited for quality control, only 25 of them (16.1%) had to change something in the records. Most the corrections were about identification data; in only six records (3.8%) the supervisor had to update morbidity data.. Discussion. This study presents an example of a simple and viable method of teleresearch in reproductive health to trace a specific subject selected from a database carried out in Brazil. Although telephone surveys have been used to explore information on health in developed settings for several years 1,15, there is still some discussion on the validity of telephone surveys for the administration of questionnaires and the mode of contact can interfere in response rates and account for selection bias in public health research. The validity of this method of collecting data needs a high rate of response to truly represent the studied population, therefore it is important to use recruitment methods that are easily reproducible 8,9,16,17.. In our study the ...
UH Clinical Research Center is committed to providing new research opportunities to investigators and assisting with recruitment challenges. In alignment with a foundational and strategic initiative to leverage information technology to simplify study participant recruitment and conduct research, the Clinical Research Center partnered with TriNetX, a global health research network that connects healthcare organizations, biopharmaceutical companies, and contract research organizations to optimize clinical research and enable discoveries.. TriNetX effectively queries electronic medical records, which optimizes the data for research activities such as study feasibility and patient recruitment. Services are available at no cost to UH principal investigators and study teams.. ...
We value our people as our greatest asset and we adopt a best practice approach in our recruitment methods to ensure that all recruitment is dealt with in a fair and efficient manner. This is reflected in our Excellence Through People Accreditation (NSAI HR Standard). Equally, we recognise that investing in the lifelong learning and development of our staff is central to the success of the organisation. We also ensure that there is emphasis placed on maximising potential while ensuring work-life balance and employee wellbeing.. To give you an insight into working with us, have a look at the Human Resources Charter 2016 - 2019 Supporting Excellence and the Career Profiles of staff working with us.. ...
Now that we have both a global rationale and advanced technical tools, many employers and learners are expressing not only an interest in digital badging, but are identifying digital badges as a need.. Employers: A Means to Improve Skills-Matching. Globally, employers are adopting virtual and digital practices to engage global talent-specifically, Millennials who are new in the workforce. Big employer brands have made significant investment in technologies-specifically HR platforms-to enhance the employee experience. These platforms include virtual recruitment methods, digital work performance reviews and documentation, collaborative work technologies and actively mining talent data to resolve skills-matching challenges (where the employees skills are not readily visible/accessible to correctly identify and match to an employer job role and skills need). Employers want to know that their current talent and prospective talent have the skills and competence they need to develop and excel in their ...
Employers are constantly on the lookout for all-rounded employees who can help the company or business meet its objectives, which explains why recruitment methods are…
AmerisourceBergens IntrinsiQ Specialty Solutions and ION Solutions have launched a clinical trial recruitment network, bringing healthcare providers and biopharma companies together.
Episode #10, recorded April 16, 2020.Many thanks to Andy Fadenholz, a physician recruiter at RosmanSearch, Inc., for joining me today. Andy specializes in placing neurologists and neurosurgeons. We discussed the advantages of using a recruitment firm that specializes in a specific market and is a...
Want to learn more about CHI Health? Our team of recruiters are happy to tell you about all CHI Health can offer caregivers and clinical staff. With extensive knowledge of our facilities, patient populations and work environments, they can help you discover the perfect first job or the ideal next career step.. ...
Candidates are often given a week or two of notice before they sit down face-to-face with a recruiter. Some will spend that time agonizing over the right clothes to wear, or figuring out the greatest weakness question. Some will make sure they have memorized their resume, start-to-finish - or map out to the exact second when to leave the house so they arent late.. Yet many will fail to do what really impresses a recruiter or hiring manager: research!. They wont go on LinkedIn to learn more about the recruiter. They wont go online to learn about next steps in the companys growth. They wont check out the organizations competition or standing in the marketplace. Many wont even take the time to understand the companys mission and culture - and to know if they are a good fit.. In the eyes of the recruiter, this lack of effort puts the candidate in the He just needs a job - any job category. And in this economy, that attitude will eliminate the candidate from consideration.. By learning ...
PHOENIX, March 24, 2020 (Newswire.com) - Since the inception of HotFoot Recruiters, the team has operated under a core value of People First. This empathic value gives the company the requisite strength and guidance to face the difficult challenge posed on the globe by the novel coronavirus (COVID-19), one which the World Health Organization recently declared as a pandemic.. Their prayers go out to the people who have been affected by this unprecedented event. HotFoot also wants to take a moment and appreciate the tireless dedication of all the healthcare workers, communities, and governments all over the world in their bid towards containing the virus.. According to the company, it has taken the necessary precautions to ensure a healthy recruiting and onboarding process for all sites across the country.. Taking the circumstances into consideration, HotFoot also understands that many companies are witnessing significant workforce and payroll challenges that need to be urgently dealt with. Rest ...
Excellent opportunity for an experienced IT / Technology Talent Acquisition / Recruiter to join an award-winning, fast-growing and highly ambitious
Moreover, keeping the military - one of Americas largest employers - off-campus would seem to be bad for students and the whole country.. I respectfully disagree. First, its patently ridiculous to assume that military recruiters have no access to college students other than on campus.. Second, given our current misadventure in Iraq, a blanket statement that keeping the military away is bad for students is highly debatable, to say the least. And the same goes for whether its bad for the country as a whole.. Its not as if other foundations making grants do not place limitations on colleges and universities.. True, but private foundations are not bound by the Bill of Rights. The Federal government (supposedly) is.. Greg is right that this ruling is misguided, though its hardly unprecedented - the Supremes have been narrowing the First Amendment where Federal funds are involved since at least the 80s (for example, the old Title X gag rule and the NEA decency provision). CIPA (censoring the ...
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The aim of the study was to evaluate the agreement between self-reported and operator-derived estimates of call time based on a three-month monitoring period, as well as the consistency of mobile phone use over time. Alternative approaches to improve participation in a cohort study of mobile phone users were also compared. A total of 5,400 subjects were identified from network operators subscriber databases for recruitment to the pilot study. Operator and questionnaire data were used to quantify mobile phone use. Operator data were available for a subset of the subjects for a three-month period in three consecutive years. We also evaluated the effect of the length of the questionnaire and one- or two-phase recruitment on participation. The average response rate for both questionnaires and recruitment procedures was 12%. The response rate was not affected by the length of the questionnaire or the recruitment method. Operator data were available for 83% of the participants for 2007, the first study year.
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Adjusted net enrolment rate, upper secondary, gender parity index (GPI) in Suriname was reported at 1.8273 GPI in 2015, according to the World Bank collection of development indicators, compiled from officially recognized sources. Suriname - Adjusted net enrolment rate, upper secondary, gender parity index - actual values, historical data, forecasts and projections were sourced from the |a href=https://data.worldbank.org/ target=blank>World Bank|/a> on April of 2020.
If you do this as a conversation of exploration and sharing what you know about the candidate pool, it will help the HM come to a decision that you can count on. And you got to it and improved your consultative image at the same time.. So as John goes back to have the conversation outlined above, he knows that no matter what she decides, he will have strengthened their relationship and her perception of him as a business partner. Plus there is a much stronger chance hell get his candidate accepted.. Check out my updated book on Amazon: The Consultative Recruiter.. For more techniques to meet 17 challenges recruiters face-and build a reputation as a consultative recruiter at the same time. Lets talk about how you can be sure that drugs you buy through a mail-order pharmacy are secure. Fortunately, there are online drugstore where you can get remedies smoothly. A prevalent form of sexual dysfunction among men is the erectile dysfunction. Below are all defense tips about how to buy viagra . ...
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Background Published studies of patients with heart failure may not include details about the challenges in the recruitment process.. Objectives To describe the recruitment process during the first 18 months of a study being conducted to evaluate cognitive deficits in patients with chronic heart failure.. Methods Details of the recruitment process are described for 2 clinic sites.. Results A total of 4027 echocardiograms were screened at site 1 to evaluate eligibility. Of the 161 patients eligible, 61 (38%) were invited to participate, and 29 of the 61 (48%) completed the study. At site 2, four hundred thirty-seven medical records of patients were screened, resulting in 163 eligible patients (37%). The staff invited 70 of the 163 patients (43%) to participate, and 52 of the 70 (74%) completed the study. The refusal rate was 23% at site 1 and 21% at site 2.. Conclusions Successful recruitment in studies involving patients with heart failure often requires screening of a large group of patients. ...
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TY - JOUR. T1 - Watchful waiting versus active surveillance. T2 - Appropriate patient selection. AU - DallEra, Marc A.. AU - Kane, Christopher J.. PY - 2009/2. Y1 - 2009/2. N2 - The prostate-specific antigen (PSA) screening era has seen dramatic stage and age migration in patients with newly diagnosed prostate cancer. The average serum PSA level of newly diagnosed patients is about 6 ng/dL, and 60% of patients are diagnosed with clinical stage T1c disease. There is evidence that many low-grade and low-stage prostate cancers have a slow growth rate and protracted clinical course, with a very low threat of metastasis or death over a prolonged interval. Many men are also appropriately concerned about the impact of prostate cancer treatment on sexual and urinary function. Therefore, delaying therapy in favor of careful surveillance, with the expectation of delivering curative treatment upon evidence of progression, is an attractive concept. In this review, we discuss active surveillance, contrast ...
Poor recruitment to randomised controlled trials (RCTs) is a widespread and important problem. With poor recruitment being such an important issue with respect to the conduct of randomised trials, a systematic review of controlled trials on recruitment methods was undertaken in order to identify strategies that are effective. We searched the register of trials in Cochrane library from 1996 to end of 2004. We also searched Web of Science for 2004. Additional trials were identified from personal knowledge. Included studies had to use random allocation and participants had to be allocated to different methods of recruitment to a real randomised trial. Trials that randomised participants to mock trials and trials of recruitment to non-randomised studies (e.g., case control studies) were excluded. Information on the study design, intervention and control, and number of patients recruited was extracted by the 2 authors. We identified 14 papers describing 20 different interventions. Effective interventions
TY - JOUR. T1 - Twenty years post-NIH Revitalization Act. T2 - enhancing minority participation in clinical trials (EMPaCT): laying the groundwork for improving minority clinical trial accrual: renewing the case for enhancing minority participation in cancer clinical trials.. AU - Chen, Moon S.. AU - Lara, Primo N.. AU - Dang, Julie H T. AU - Paterniti, Debora A.. AU - Kelly, Karen. PY - 2014. Y1 - 2014. N2 - The National Institutes of Health (NIH) Revitalization Act of 1993 mandated the appropriate inclusion of minorities in all NIH-funded research. Twenty years after this act, the proportion of minority patients enrolled in cancer clinical trials remains persistently low. Clinical trials are vehicles for the development and evaluation of therapeutic and preventive agents under scientifically rigorous conditions. Without representation in trials, it is projected that disparities in the cancer burden for minorities will increase. For this review article, the authors counted the frequency with ...
Mumbai (Maharashtra) [India], July 29 (ANI): Making way for recruitment by the Maharashtra Public Service Commission (MPSC), the state government has allowed special exemption from restrictions put on the recruitment process in the state.
Compared with TAU, both TCBT and WCBT intervention arms showed clinically important and/or statistically significant improvements in all primary and secondary outcomes at all time points sustained at 12 months. These results indicate that both TCBT and WCBT are effective treatments for refractory moderately severe IBS compared with TAU.. Trial strengths include a well-powered rigorously conducted RCT with broad inclusion and long-term follow-up. The IBS-specific CBT was based on an explicit theoretical model19 which informed detailed patient and therapy manuals and the WCBT (Regul8). Therapists were experienced in delivering CBT and trained and supervised to deliver IBS-specific CBT. Trial interventions had good treatment fidelity and were delivered by NHS therapists in an NHS setting.. In terms of limitations, trial participants may not be representative of all patients with IBS. To address this, we used broad inclusive recruitment methods from primary and secondary care. However, people ...
Background: Our clinical trial of a mobile exercise intervention for adults 18 to 65 years old with type 1 diabetes (T1D) occurred during COVID-19 social distancing restrictions, prompting us to test web-based recruitment methods previously underexplored for this demographic. Objective: Our objectives for this study were to (1) evaluate the effectiveness and cost of using social media news feed advertisements, a clinic-based approach method, and web-based snowball sampling to reach inadequately active adults with T1D and (2) compare characteristics of enrollees against normative data. Methods: Participants were recruited between November 2019 and August 2020. In method #1, Facebook and Instagram news feed advertisements ran for five 1-to-8-day windows targeting adults (18 to 64 years old) in the greater New Haven and Hartford, Connecticut, areas with one or more diabetes-related profile interest. If interested, participants completed a webform so that the research team could contact them for eligibility
The static respiratory system pressure-volume (P-V) curve is often measured in intubated, mechanically ventilated patients to make inferences about the mechanical properties of the lungs. Although the utility of P-V measurements in clinical decision-making remains to be established, the determinants of the P-V relationship should nevertheless be understood. The P-V curve is generated by inflating and deflating the relaxed respiratory system in a stepwise fashion between residual volume and total lung capacity. The airway occlusion pressure at each volume defines the corresponding elastic recoil pressures of the lungs and chest wall. Because the inflation and deflation relationships differ from each other, the resulting curve is often referred to as a P-V loop. The respiratory system P-V loop is the summation of individual lung and chest wall P-V loops, termed a Rahn diagram Failure to oxygenate is treated by recruitment methods, increased baseline airway pressures using CPAP, and restoration of ...
Trials in primary care to increase physical activity (PA) typically experience poor recruitment rates and may not recruit those with lower PA levels and who are most in need of the intervention. Despite the well-publicised benefits of physical activity, the majority of adults in the UK remain inactive and, therefore, at greater risk of many health problems. Our aim was to investigate the reasons for non-participation in the PACE-UP trial, which is a primary care pedometer-based walking intervention. This is important for successful recruitment and retention in future PA trials and programmes. We conducted semi-structured audio-recorded telephone interviews with 30 participants, aged 45-75 years, purposively sampled from those declining participation in the PACE-UP trial. Recruitment continued until data saturation and a demographically balanced sample was achieved. Interviews were transcribed verbatim, coded and subjected to thematic analysis. Interviewees supported walking as suitable exercise for most
UW Health is one of the national leaders in outcomes using ventricular assist devices for patients with end-stage heart failure. Our team uses a broad spectrum of ventricular assist devices (VAD), tailoring selection to meet each patients individual needs.
One thing we can count on in the healthcare industry is change. Healthcare reform. Changes in reimbursements. New technologies to help us do our jobs. Keeping up with change presents challenges and sometimes, decisions made based on current information need to be re-evaluated because it turns out that they may not have been the best choices.. In consideration of evolving employment models for in-house physician recruiters, ASPR has taken time to re-evaluate the decision made in 2011 to re-categorize members into three distinct categories. Through this review, we realized that some of the newer in-house recruitment models operate in much the same way as the more traditional model and that we are missing opportunities to learn and grow from one another by segmenting membership into multiple categories. We believe it is imperative that we embrace the changes in our industry, be more inclusive, and continue to evolve and grow. To this end, the ASPR Board of Directors voted to combine the Affiliate ...
Although the sport of rugby union has expanded globally in both the mens and womens formats recently, there remains an under-representation of women coaches across all contexts. Research has focused its analysis on the under-representation of women coaches in a select few sports such as soccer. No extant research has empirically analyzed this under-representation within rugby union. This study addressed this research lacuna on why this under-representation exists from the perspective of 21 women rugby union coaches based within the United Kingdom and Ireland. The specific research objective was to analyze the coaches lived experiences of attending formal coach education courses in rugby union. Data were collected through individual semi-structured interviews. Data were analyzed thematically and conceptualized via an abductive logic against LaVois Ecological-Intersectional Model and Pierre Bourdieus species of capital. Supportive and positive themes reported how the coach education courses ...
Data science interview questions will ease the process of interviewing candidates at different stages of candidate evaluation for technical recruiters and hiring managers. Data science interview questions have been divided into 3 categories - technical, statistical & experience-based questions to help interviewer in assessing the applicants specific to the job-requirement.
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ROSEVILLE, Minn.-Ramsey County prosecutors will consider charges against a man accused of striking two U.S. Army recruiters and dragging one of them under his SUV. Police say the two uniformed recruiters were struck Tuesday afternoon as they walked near the Crossroads shopping center in Roseville. Officials say one of the recruiters, a 42-year-old Circle Pines man, was trapped under the Jeep Cherokee and was dragged about three-quarters of a mile before he was able to free himself. Roseville police say the recruiter suffered a broken leg and other severe injuries which are not believed to be life threatening. The second victim, a 29-year-old Brooklyn Center man, was thrown over the hood of the SUV, but was able to walk away with minor injuries. Police arrested the driver at a car dealership in Roseville.. ...
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TY - JOUR. T1 - An assessment of the feasibility and acceptability of a friendship-based social network recruitment strategy to screen at-risk african american and hispanic/latina young women for HIV infection. AU - Boyer, Cherrie B.. AU - Hightow-Weidman, Lisa. AU - Bethel, James. AU - Li, Su X.. AU - Henry-Reid, Lisa. AU - Futterman, Donna. AU - Maturo, Donna. AU - Straub, Diane M.. AU - Howell, Kourtney. AU - Reid, Shirleta. AU - Lowe, Jaime. AU - Kapogiannis, Bill G.. AU - Ellen, Jonathan M.. PY - 2013/3. Y1 - 2013/3. N2 - Objectives: To examine the feasibility and acceptability of a friendship-based network recruitment strategy for identifying undiagnosed human immunodeficiency virus (HIV) infection within young womens same-sex friendship networks and to determine factors that facilitated and hindered index recruiters (IRs) in recruiting female friendship network members (FNMs) as well as factors that facilitated and hindered FNMs in undergoing HIV screening. Design: A cross-sectional ...
Savita Kanade is working as Community Coordinator for NIH funded clinical trials at BJGMC-CRS, Pune, India. At present she is serving as Co-chair on Outreach Recruitment and Retention subcommittee (OR&R) of SMCCC, ACTG. Her main duties as co-chair include developing agenda for monthly conference calls and OR&R business sessions at ACTG leadership retreat meetings, recording and distributing summaries of calls and meetings to parent committee, identify and address ACTG sites needs related to study recruitment and retention, facilitating development of and designing study recruitment flyers, maintaining the OR&R website and updating documents, leading OR&R committee sessions at the annual ACTG network meetings and the annual ACTG leadership retreats, representing OR&R on the Cross-Network committees such as PDISC, TES and the SMCCC, increasing involvement of GCAB members in monthly OR&R calls and getting their input on participant recruitment and retention, study flyers, etc.. As part of NIH ...
Omni Resource Management Solutions discusses addresses and defines what recruitment process outsourcing is and how it works in the recruitment industry.
We were one of six delighted community groups across Northern Ireland celebrating a shared award of £1 million from The National Lottery this June, receiving a £112,124 share of this total fund to employ 2 part-time members of staff who will work on an outreach basis.. We have since had a very successful recruitment programme which took place in August with plans for the new project and recruits to begin in November.. The project will provide practical advice, signposting, peer support and volunteering opportunities. It will also work to improve networking, partnership engagement and seek to influence relevant policy.. Fiona McLaughlin, Chair of Northern Ireland Rare Disease Partnership comments We are absolutely delighted to have this remarkable opportunity to provide the additional support that is so crucial to all our members. This is first for us in Northern Ireland and we are keen to ensure that this funding will make a real difference to families, carers, medical professionals and ...
The proposed pilot study will utilize a cross-sectional research design to recruit Hispanic/Latina and African American young women to undergo HIV screening. The research design will consist of a friendship-based, female network recruitment approach that incorporates a dual method of incentives for index recruiters and network members as a strategy for identifying new HIV infections in the target population. Among sexually experienced young women (many of whom who reside in communities with a high prevalence of STIs and HIV), 50 who self-identify as HIV positive, 50 who self-identify as HIV negative (based on receiving a negative HIV test within 12 months prior to study consent), and 50 whose HIV status is self-reported as unknown (who have no history of prior HIV testing or who had HIV screening more than 12 months prior to date of study consent) will be recruited. These women will serve as index recruiters to recruit two or more (on average four) female friendship network members to undergo ...
The proposed pilot study will utilize a cross-sectional research design to recruit Hispanic/Latina and African American young women to undergo HIV screening. The research design will consist of a friendship-based, female network recruitment approach that incorporates a dual method of incentives for index recruiters and network members as a strategy for identifying new HIV infections in the target population. Among sexually experienced young women (many of whom who reside in communities with a high prevalence of STIs and HIV), 50 who self-identify as HIV positive, 50 who self-identify as HIV negative (based on receiving a negative HIV test within 12 months prior to study consent), and 50 whose HIV status is self-reported as unknown (who have no history of prior HIV testing or who had HIV screening more than 12 months prior to date of study consent) will be recruited. These women will serve as index recruiters to recruit two or more (on average four) female friendship network members to undergo ...
TY - JOUR. T1 - Factors associated with trial recruitment, preferences, and treatments received were elucidated in a comprehensive cohort study. AU - Donovan, Jenny L.. AU - Opmeer, Brent. AU - Young, Grace J.. AU - Mills, Nicola. AU - Martin, Richard M.. AU - Lane, J. Athene. AU - Metcalfe, Chris. AU - Peters, Tim J.. AU - Davis, Michael. AU - Turner, Emma L.. AU - Walsh, Eleanor. AU - Neal, David E.. AU - Hamdy, Freddie C.. AU - ProtecT Study Group. AU - Holding, Peter. AU - Mason, Malcolm. AU - Catto, James W.F.. AU - Rosario, Derek J.. AU - Staffurth, John. AU - Kynaston, Howard. AU - Hughes, Owen. AU - Bollina, Prasad. AU - Doherty, Alan. AU - Gnanapragasam, Vincent. AU - Kockelbergh, Roger. AU - Paul, Alan. AU - Paez, Edgar. AU - Gillatt, David. AU - Rowe, Edward. AU - Oxley, Jon. N1 - Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the ...
by HUCAMA , Feb 1, 2018 , Blog, Human Resource Management, Interview Techniques, Recruitment. Choosing the wrong candidate is expensive for the employee as well as the company. Using the right interview technique is one of the best ways to ensure a successful recruitment. While there are many different types of interviewing, there is concrete evidence to ...
Mechanical circulatory support has become an increasingly common method of supporting patients with advanced heart failure. Paramount to the recent progress observed with this therapy has been a greater understanding of patient selection criteria as a primary determinant of early and late patient outcomes. Prior to device implant, patients should undergo a multidisciplinary evaluation of cardiovascular, noncardiovascular, and psychosocial factors that influence postoperative outcomes. The use of multivariable risk scores may also be useful to guide discussions with patients and families regarding the relative risks of different therapeutic alternatives. Despite an evidence base that provides guiding principles in patient selection for mechanically assisted circulation, several aspects of the evaluation require further refinement, including development of tools to objectively assess psychosocial parameters, and definition and validation of measures of right ventricular dysfunction that preclude
The pleasures and terrors of trial recruitment were described by Dr Maguire. Everybody struggling with meeting the recruitment targets should read the top 10 tipsfor recruiting into trials at the All-Ireland Hub for Trials Methodology Research website. Trialists should plan for what theyre going to do if things dont go the way they planned. Recruiters can also become tired and its good to think ahead about what would possibly prevent them from recruiting. Even small rewards to recruiters, such as cream eggs, can increase their satisfaction. Satisfaction=Retention. Research networks for General Practitioners can facilitate recruitment. ...
The most recent, 2014, is the first cohort whose enrollment rate increased from the previous year, the report noted. Previously, all graduating classes included in this report had a lower enrollment rate than their previous year.. The report is good news because so many of the jobs in our technology and information based economy require post-secondary credentials, said Lt. Gov. Joe Garcia, whos also executive director of the department. However, the report also reveals that we have continuing and significant gaps in post-secondary outcomes and that students from certain demographic groups are doing much better than others. If we are to meet our education and workforce goals, we must do a better job of supporting low income, rural, and minority students so that they graduate with a credential that will lead to a living wage job.. Overall college enrollment tends to rise when the economy is weak and drop when times improve. Fall enrollment in 2014 was 251,778, down from the recent high of ...
When evaluating a patient with an inguinal hernia and considering a laparoscopic or endoscopic approach, several factors need ... but is as important in patient selection and choice of operation. Proper patient selection would require a panoramic view of ... Iskandar M., Ferzli G. (2018) Patient Selection for Laparoendoscopic Inguinal Hernia Repair. In: Bittner R., Köckerling F., ... When evaluating a patient with an inguinal hernia and considering a laparoscopic or endoscopic approach, several factors need ...
Patients with neurological disease origins. BOWEL CONTROL CANDIDATES. A broad range of chronic fecal incontinent patients are ... Sacral Neuromodulation is not appropriate for patients who:. *Have not demonstrated an appropriate response to the evaluation ( ... Sacral Neuromodulation, delivered by the Interstim™ system, is indicated for patients who have failed or could not tolerate ... A broad range of patients with overactive bladder and non-obstructive urinary retention are considered suitable for Sacral ...
Learn more about patient criteria for this therapy. ... Deep brain stimulation therapy may be an option for patients ... IS DBS THERAPY RIGHT FOR YOUR PATIENT? Download the patient candidacy tool and assess your patient now. ...
Artificial urinary sphincter Incontinence Management Surgical technique Patient selection This is a preview of subscription ... Pariser J.J., Cohen A.J., Rosen A.M., Bales G.T. (2016) Artificial Urinary Sphincter: Patient Selection and Surgical Technique ... and this chapter will focus on the essential aspects of patient selection and operative technique. ... Urethral buttressing in patients undergoing artificial urinary sphincter surgery. J Urol. 2013;189:1777-81.CrossRefPubMedGoogle ...
... Guest Editors: Natan Zundel, Sayeed Ikramuddin, and ... Optimizing Outcomes in Bariatric Surgery: A Primer in Patient Selection, Natan Zundel, Sayeed Ikramuddin, and Raul Rosenthal ... Perioperative Optimization of Patients Undergoing Bariatric Surgery, C. E. Owers, Y. Abbas, R. Ackroyd, N. Barron, and M. Khan ... Candidates for Bariatric Surgery: Morbidly Obese Patients with Pulmonary Dysfunction, Yu-Feng Wei and Huey-Dong Wu Volume 2012 ...
... by the FDA to serve as an adjunct to the dentists professional judgment of how to best use diagnostic imaging for each patient ... A study of 490 patients found that basing selection criteria on clinical evaluations for asymptomatic patients, combined with ... Patient Selection Criteria. Radiographs and other imaging modalities are used to diagnose and monitor oral diseases, as well as ... The guidelines titled, "The Selection of Patients for X-Ray Examination" were first developed in 1987 by a panel of dental ...
How to select patients for antireflux surgery? The ICARUS guidelines (international consensus regarding preoperative ... examinations and clinical characteristics assessment to select adult patients for antireflux surgery) Ans Pauwels, Veerle ...
Clinical trial execution can be hindered by patient and investigator frustrations. Learn how Parexel can help to streamline ... and patients. Our Patient Recruitment and Strategy Group gives you solutions to identify volunteers, then keep them engaged ... Patient recruitment materials provided site investigators and Consent+, our award-winning electronic informed consent platform ... A new paradigm in development to reimburse investigators within 60 days of patient visit, rather than the typical 6 months ...
This fact points to a stricter selection of patients with high medical risks and therefore to better discrimination of patients ... Patient Selection for Carotid Endarterectomy. How Far Is Risk Modeling Applicable to the Individual?. Alain Barth, Claudio ... The selection criteria of Rothwell et al were prospectively applied to all patients without influencing the decision to operate ... In the present study, the selection model of Rothwell et al10 was prospectively applied to a consecutive series of patients ...
patient selection strategy linked to target expression on the tumor is thus critically important.... ... "The development of a patient selection strategy linked to target expression on the tumor is thus critically important for ... Article Highlights Importance of Careful Patient Selection in Mesothelioma Immunotherapy Treatment, According to Surviving ... Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions. ...
Home › EAU News › All › Patient selection: crucial in RCC treatment. Patient selection: crucial in RCC treatment. 26 February ... With the entry of so-called targeted therapy (TT), patient selection and individualised treatment strategies will become more ... Bex, meanwhile, stressed in his lecture that patients selection will prove crucial. ... "Its all about selection," Bex said. In his concluding remarks he underscored the following:. - There is no evidence supporting ...
The male factor of infertility should not be an issue for the selection of patients for extended embryo culture programmes. ... Uterus transplantation for absolute uterine factor infertility: Ethics, patient selection, and consent. Authors. Mats ... This topic will discuss the ethics, indications, and patient selection for uterus transplantation, an experimental approach to ... The purpose of this topic is to provide information on this developing technology for clinicians and patients; the topic is not ...
While "good patient selection" may sound like a simple objective, achieving good patient selection remains a constantly ... Patient selection in TEVAR requires better risk stratification to better select patients for this new procedure. ... By using these guidelines to improve patient selection, our risk models can help patients, physicians, and policymakers improve ... By using these guidelines to improve patient selection, our risk models can help patients, physicians, and policymakers improve ...
To the Editor We congratulate Grant et al1 on their multi-centre study on the impact of endoscopic vein harvesting (EVH) on clinical outcomes. Their results echoed nicely with the studies by Dacey et al2 and Ouzounian et al3 who showed EVH is not an independent predictor of inhospital or mid-term adverse outcomes. However, it is interesting to note that only 12.4% of their studied population received EVH. The study also highlighted the … ...
Use of lung transplantation survival models to refine patient selection in cystic fibrosis.. Liou TG1, Adler FR, Huang D. ... Identifying characteristics that affect post-transplantation survival may improve patient selection and survival benefit. Using ... Transplantation never improves survivorship for pediatric patients. Patients with arthropathy, B. cepacia infection, or younger ... Adult patients with low 5-year predicted survival without B. cepacia infection should receive priority for lung transplantation ...
Patient Selection for Urodynamic Studies. The history and physical examination alone may not provide sufficient and accurate ... Selection of patients for complex urodynamic testing can be difficult. Universally agreed-upon criteria for complex testing do ... Patients with low flow rates may be at risk for prolonged catheterization. In one study, 38% of the patients with abnormal ... Patient position during testing varies, but most commonly, the patient is sitting, semi-erect, or standing. The catheters ...
The entire paper can be read here ACTIVE SURVEILLANCE FOR PROSTATE CANCER: PATIENT SELECTION AND MANAGEMENT. Diagnosed 96: Age ... Active surveillance for prostate cancer: patient selection and management L. Klotz, MD is a paper published in last months ... HealingWell.com Forum , Diseases & Conditions , Prostate Cancer , Active surveillance patient selection and management ... By the way, I dont really think your "Main Uro" would be so stupid as to say that 30% of AS patients die of PC. My guess is ...
Change of Patient Selection Strategy and Improved Surgical Outcome in MRI-negative Neocortical Epilepsy.. Moon HJ1, Kim DW2, ... The new patient selection strategy led to a significant increase in the concordance between two or more modalities. The ... as a new patient selection strategy for MRI-negative neocortical epilepsy surgery. The objective of this study was to evaluate ... The old group consisted of 89 patients and the new one consisted of 53 patients. Clinical characteristics, presurgical ...
... to support patient selection and efficacy evaluation in its global clinical trials, Aprinoia said, through a deal whose value ... Home Neurological Disorders Alzheimers Celgene Licenses Aprinoia Tau PET Tracer APN-1607 to Support Patient Selection in... ... Celgene Licenses Aprinoia Tau PET Tracer APN-1607 to Support Patient Selection in Trials. January 2, 2019. 0 ... to support patient selection and efficacy evaluation in its global clinical trials, Aprinoia said today, through a deal whose ...
Clinical indicators results for Memorial Hermann hospitals when compared to the current benchmarks for antibiotic selection for ...
... optimal patient selection remains challenging due to substantial treatment heterogeneity among patients who meet the clinical ... patient sample (test dataset). Among 990 patients receiving CRT the mean age was 71.6 (SD, 11.8), 78.1% were male, 87.2% non- ... Patients accrued on average 75 clinical notes (SD, 29) before the procedure including data not captured anywhere else in the ... A machine learning model was built using 80% of the patient sample (training and validation dataset), and tested on a held-out ...
Careful selection of high-risk patients for immediate intervention with locoregional muscle flaps may reduce surgical ... Appropriate patient selection may yield reduced morbidity in spinal resection. Devulapalli C, et al. Plast Reconstruct Surg. ... Careful selection of high-risk patients for immediate intervention with locoregional muscle flaps may reduce surgical ... Careful selection of high-risk patients for immediate intervention with locoregional muscle flaps may reduce surgical ...
Corus CAD is intended for use in stable patients presenting with non-acute typical and atypical symptoms suggestive of ... Corus CAD Patient Selection The Corus CAD test is intended for use in patients who present with stable symptoms suggestive of ...
... today announced the joint development of a decision support system that allows clinicians and patients to choose from available ... Pharmacotherapy selection system supports shared clinician-patient decision-making in diabetes treatment. ... Pharmacotherapy selection system supports shared clinician-patient decision-making in diabetes treatment ... Pharmacotherapy selection system supports shared clinician-patient decision-making in diabetes treatment ...
Check out content recommended for you by our medical editors (based on your scope of practice selections in your work profile) ... and patient safety MOC credit] in the American Board of Internal Medicines (ABIM) Maintenance of Certification (MOC) program. ... allowing you to stay abreast of developments in your field and improve your standards of care for your patients. ... Improvement in Medical Practice and/or Patient Safety requirements for the American Board of Ophthalmologys Maintenance of ...
The aim of this review is to describe specific indications and patients who may benefit from robotic-assisted hysterectomy. ... and obese patients. In the future, additional evidence regarding the benefits of single-site robotic hysterectomy may further ... Minimally invasive hysterectomy via the laparoscopic or vaginal approach is beneficial to patients when compared with ... patient selection and perspectives Noam Smorgick Departments of Obstetrics and Gynecology, Assaf Harofe Medical Center, ...
... while consulting with physicians to support a multidisciplinary based patient selection. In addition, psychologists take part ... substantiating the need for standardized assessment techniques to incorporate psychosocial factors in patient selection. ... in preparing patients who were initially deemed unsuitable for SCS by providing recommendations and potential access to ... Patient Selection for Spinal Cord Stimulators: Mental Health Perspective Research has shown that psychosocial factors can ...
... when matching patients and physicians on the basis of value and quality rather than costs and outcomes can help a patient ... Patient-Centered Physician Selection: A Necessary First Step for Accountable Care. Brian Powers, BA and Sachin H. Jain MD, MBA ... There is a notable gap in our system wide efforts to promote accountable, patient-centered care: physician selection. The past ... Patients are sensitive to system characteristics such as wait times, the use of patient portals, physician use of electronic ...
Bernabéu discusses several examples of patients for whom multifocal lenses are not suitable.

The product… ... speaks about the importance of patient selection when it comes to implanting trifocal intraocular lenses. Dr. ... The Importance of Patient Selection Gonzalo Bernabéu, MD. Channels: Cataract Surgery Gonzalo Bernabéu, MD, speaks about the ... Gonzalo Bernabéu, MD, speaks about the importance of patient selection when it comes to implanting trifocal intraocular lenses ...
Patient selection for.... *Patient selection for high sensitivity cardiac troponin testing and diagnosis of myocardial ... To ensure that every eligible patient was included and avoid selection bias, consent was not sought from patients. All results ... of all patients. Type 1 myocardial infarction adjudicated in 68 (4.2%) patients, with 102 (6.3%) and 245 (15.0%) patients ... 500 patients, medium dot 500-1500 patients, large dot ,1500 patients). Blue line represents central estimate of positive ...
  • Both sides now say they want jury selection to begin on August 31, but the judge still needs to sign off on that. (gossipnewskiosk.com)
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  • To be as clinically relevant as possible, the book includes sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effects, and case studies that introduce clinical problems in many chapters. (uwi.edu)
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  • I do not make a good patient, and it's extremely frustrating and irritating to be limited in what I can do, and to be in as much pain as I am, from doing the simplest of tasks. (tramplingrose.com)
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  • Use cases include kiosks in stores and use of iOS devices for single purposes such as for poll-takers or patient registration. (infoworld.com)
  • For example, pain level is not an easy thing for doctors to determine in terms of their patients. (thenakedscientists.com)
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  • Selection of the subject matter and order of its presentation are based on the authors' many years experience in teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students. (uwi.edu)
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  • It was a smooth and collaborative experience from the shoot to the processing and to the final selection. (daphotostudio.com)
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  • If you're current bike works for you, I would advise to be patient and wait for the supply chain problems caused by the pandemic to resolve. (bikeforums.net)

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