Patient Isolation: The segregation of patients with communicable or other diseases for a specified time. Isolation may be strict, in which movement and social contacts are limited; modified, where an effort to control specified aspects of care is made in order to prevent cross infection; or reverse, where the patient is secluded in a controlled or germ-free environment in order to protect him or her from cross infection.Missions and Missionaries: To be used for articles pertaining to medical activities carried out by personnel in institutions which are administered by a religious organization.Quarantine: Restriction of freedom of movement of individuals who have been exposed to infectious or communicable disease in order to prevent its spread; a period of detention of vessels, vehicles, or travelers coming from infected or suspected places; and detention or isolation on account of suspected contagion. It includes government regulations on the detention of animals at frontiers or ports of entrance for the prevention of infectious disease, through a period of isolation before being allowed to enter a country. (From Dorland, 28th ed & Black's Veterinary Dictionary, 17th ed)GeorgiaMedical Missions, Official: Travel by a group of physicians for the purpose of making a special study or undertaking a special project of short-term duration.Hemorrhagic Fever, Ebola: A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.Hospital Design and Construction: The architecture, functional design, and construction of hospitals.North CarolinaSocial Isolation: The separation of individuals or groups resulting in the lack of or minimizing of social contact and/or communication. This separation may be accomplished by physical separation, by social barriers and by psychological mechanisms. In the latter, there may be interaction but no real communication.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Survivors: Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.Breast Neoplasms: Tumors or cancer of the human BREAST.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Breast: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.Financial Management, Hospital: The obtaining and management of funds for hospital needs and responsibility for fiscal affairs.Day Care: Institutional health care of patients during the day. The patients return home at night.Lead Radioisotopes: Unstable isotopes of lead that decay or disintegrate emitting radiation. Pb atoms with atomic weights 194-203, 205, and 209-214 are radioactive lead isotopes.Frail Elderly: Older adults or aged individuals who are lacking in general strength and are unusually susceptible to disease or to other infirmity.Asia: The largest of the continents. It was known to the Romans more specifically as what we know today as Asia Minor. The name comes from at least two possible sources: from the Assyrian asu (to rise) or from the Sanskrit usa (dawn), both with reference to its being the land of the rising sun, i.e., eastern as opposed to Europe, to the west. (From Webster's New Geographical Dictionary, 1988, p82 & Room, Brewer's Dictionary of Names, 1992, p34)Lilium: A plant genus in the family LILIACEAE generally growing in temperate areas. The word lily is also used in the common names of many plants of other genera that resemble true lilies. True lilies are erect perennial plants with leafy stems, scaly bulbs, usually narrow leaves, and solitary or clustered flowers.Asian Continental Ancestry Group: Individuals whose ancestral origins are in the southeastern and eastern areas of the Asian continent.Chlamydophila pneumoniae: A species of CHLAMYDOPHILA that causes acute respiratory infection, especially atypical pneumonia, in humans, horses, and koalas.Chlamydia Infections: Infections with bacteria of the genus CHLAMYDIA.Chlamydophila Infections: Infections with bacteria of the genus CHLAMYDOPHILA.Chlamydia: A genus of the family CHLAMYDIACEAE whose species cause a variety of diseases in vertebrates including humans, mice, and swine. Chlamydia species are gram-negative and produce glycogen. The type species is CHLAMYDIA TRACHOMATIS.Chlamydia trachomatis: Type species of CHLAMYDIA causing a variety of ocular and urogenital diseases.Mycoplasma pneumoniae: Short filamentous organism of the genus Mycoplasma, which binds firmly to the cells of the respiratory epithelium. It is one of the etiologic agents of non-viral primary atypical pneumonia in man.Klebsiella pneumoniae: Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.Access to Information: Individual's rights to obtain and use information collected or generated by others.Rheumatoid Factor: Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.Gastroenterology: A subspecialty of internal medicine concerned with the study of the physiology and diseases of the digestive system and related structures (esophagus, liver, gallbladder, and pancreas).Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Hepatitis C: INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.Ehrlichia: Small, often pleomorphic, coccoid to ellipsoidal organisms occurring intracytoplasmically in circulating LYMPHOCYTES. They are the etiologic agents of tick-borne diseases of humans; DOGS; CATTLE; SHEEP; GOATS; and HORSES.Ehrlichiosis: A tick-borne disease characterized by FEVER; HEADACHE; myalgias; ANOREXIA; and occasionally RASH. It is caused by several bacterial species and can produce disease in DOGS; CATTLE; SHEEP; GOATS; HORSES; and humans. The primary species causing human disease are EHRLICHIA CHAFFEENSIS; ANAPLASMA PHAGOCYTOPHILUM; and Ehrlichia ewingii.Ehrlichia chaffeensis: A species of gram-negative bacteria that is the causative agent of human EHRLICHIOSIS. This organism was first discovered at Fort Chaffee, Arkansas, when blood samples from suspected human ehrlichiosis patients were studied.Ehrlichia canis: Species of gram-negative bacteria in the family ANAPLASMATACEAE, causing EHRLICHIOSIS in DOGS. The most common vector is the brown dog tick. It can also cause disease in humans.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Rickettsiaceae Infections: Infections with bacteria of the family RICKETTSIACEAE.Ticks: Blood-sucking acarid parasites of the order Ixodida comprising two families: the softbacked ticks (ARGASIDAE) and hardbacked ticks (IXODIDAE). Ticks are larger than their relatives, the MITES. They penetrate the skin of their host by means of highly specialized, hooked mouth parts and feed on its blood. Ticks attack all groups of terrestrial vertebrates. In humans they are responsible for many TICK-BORNE DISEASES, including the transmission of ROCKY MOUNTAIN SPOTTED FEVER; TULAREMIA; BABESIOSIS; AFRICAN SWINE FEVER; and RELAPSING FEVER. (From Barnes, Invertebrate Zoology, 5th ed, pp543-44)Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Pancreatic Ducts: Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.Organoids: An organization of cells into an organ-like structure. Organoids can be generated in culture. They are also found in certain neoplasms.Carcinoma, Acinar Cell: A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)KentuckyAtherosclerosis: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.

Immunological reconstitution and correlation of circulating serum inflammatory mediators/cytokines with the incidence of acute graft-versus-host disease during the first 100 days following unrelated umbilical cord blood transplantation. (1/231)

We investigated early immunological reconstitution and the production of circulating inflammatory mediators and their relationship to aGVHD in children during the first 100 days following unrelated UCBT. Nine patients had an underlying malignant disease (ALL, ANLL), and two, non-malignant diseases (SAA, ALD). The median age was 10 years (range: 1.25-21). Seven of 11 patients were alive by day 100, two died from regimen-related toxicity, and two died from severe aGVHD (grade >/=III). Myeloid engraftment (ANC >/=500/mm3 x 2 days) occurred at a median of 24 days (range: 14-55), while platelet engraftment (platelet count >/=20 000/mm3 untransfused x 7 days) was delayed and occurred at a median of 52 days (range: 33-95). The mean cell dose of CD34+ cells was 3.3 +/- 3.51 x 10(5)/kg, and of CD34+/CD41+ cells was 3.94 +/- 3.99 x 10(4)/kg. Acute GVHD (grade II-IV) developed in seven patients (77%), and severe aGVHD (grade III-IV) developed in five patients (55%). Serum levels of IL-2Ralpha, IL-2, IL-4, IL-7, IL-12, and IFNgamma were not significantly different between patients with grades 0-I aGVHD and patients with grades II-IV aGVHD. Evaluation of immunological reconstitution on day 90 post UCBT demonstrated an early recovery of the absolute numbers of B cells (CD19+) and NK cells (CD3-/CD56+). Immunoglobulin levels for IgG, IgM and IgA remained normal throughout the study period. PMN functional studies demonstrated normal superoxide generation, bacterial killing (BK), and chemotaxis (CTX). However, both helper (CD3+/CD4+) and suppressor (CD3+/CD8+) T cell subsets remained low during the first 100 days post UCBT with mean +/- s.e.m. values of 120 +/- 29/mm3 and 10 +/- 50/mm3, respectively (normal = 900-2860/mm3 (CD3/CD4), normal = 630-1910/mm3 (CD3/CD8)). Mitogen response studies showed low blastogenesis to PHA and PWM, with a mean c.p.m. +/- s.e.m. value of 1.7 +/- 0.67 x 10(4) for PHA (NL >/= 75 x 10(3)) and 8.42 +/- 4.1 x 10(3) for PWM (NL >/=25 x 10(3)). In conclusion, serum levels of inflammatory mediators were not predictive nor did they correlate with the severity of aGVHD. Recovery of NK cells, B cells, and PMN functions occurred within the first 90 days post transplant. However, T cell subsets, CD3+/CD4+ and CD3+/CD8+, and T cell functional activity remained significantly decreased and may account for the high incidence of infectious morbidity seen during this immediate post UCBT period.  (+info)

Comparison of direct and concentrated acid-fast smears to identify specimens culture positive for Mycobacterium spp. (2/231)

Microscopic examination of respiratory specimens for acid-fast bacilli (AFB) plays a key role in the initial diagnosis of tuberculosis, monitoring of treatment, and determination of eligibility for release from isolation. The objective of this study was to compare the sensitivity obtained with smears for detection of AFB (AFB smears) made directly from respiratory specimens (direct AFB smears) to that obtained with parallel smears made from concentrates of the specimens (concentrated AFB smears). A total of 2,693 specimens were evaluated; 1,806 were from the University of California Irvine Medical Center Medical Microbiology Laboratory (UCIMC), which serves a tertiary-care hospital with outpatient clinics, and 887 were from the Microbial Disease Laboratory at the California Department of Public Health (MDL), which receives specimens from outpatient facilities and clinics on Pacific islands. Of the 353 AFB culture-positive specimens at UCIMC, there was a statistically significant difference in the sensitivity of the direct AFB smear (34%) and that of the smear made from the concentrated specimen (58%) (P < 0.05). This was also true for the 208 specimens positive for Mycobacterium tuberculosis, for which the sensitivity of the direct smear was 42% (87 of 208) and that for the smear made from the concentrated specimen was 74% (154 of 208). At MDL, where all but 1 of the 45 culture-positive specimens grew M. tuberculosis, the sensitivity of the smear made from the concentrated specimen was 93% (42 of 45) and was not significantly higher than the sensitivity of the direct smear, which was 82% (37 of 45). By combining the results from both laboratories, 42 patients from whom at least three specimens were received were culture positive for M. tuberculosis. The cumulative results for the initial three specimens from these patients showed that the direct smear detected M. tuberculosis in 81% of these patients, whereas the smear made from the concentrate detected M. tuberculosis in 91% of these patients. In summary, when all culture-positive specimens are considered, the sensitivity of the direct smear compared to that of a smear made from the concentrated specimen was significantly different overall in the two different laboratory settings. However, this difference was reduced only if the cumulative results for the initial three specimens received from patients who were culture positive for M. tuberculosis were evaluated.  (+info)

Infectious complications after autologous peripheral blood progenitor cell transplantation followed by G-CSF. (3/231)

Infectious complications after autologous peripheral blood progenitor cell transplantation (PBPCT) have been reported in a few studies including small patient numbers. The present study was performed to assess the incidence, types, outcome and factors affecting early and late infections in 150 patients aged 18 to 68 years (median 46.5) who underwent high-dose therapy, with G-CSF. Patients were kept in reverse isolation rooms and received antimicrobial chemoprophylaxis with oral quinolone and fluconazole. One hundred and fifteen patients (76.7%) developed fever (median 3 days, range 1-29); 20 patients (55.5%) had Gram-positive and 13 (36. 2%) Gram-negative bacterial infections. There were no fungal infections or infection-related deaths. Mucositis grade II-IV (P = 0. 0001; odds ratio 3.4) and >5 days on ANC <100/microl (P = 0.0001; odds ratio 2.3) correlated with development of infection. Only days with ANC <100/microl affected infection outcome (P = 0.0024) whereas the antibiotic regimen did not. After day +30 there were four cases of bacterial pneumonitis (2.7%), one case of fatal CMV pneumonia (0. 8%) and 20 of localized VZV infection (13.3%). Reduction of neutropenia duration with PBPCT and G-CSF is not enough to prevent early infectious complications since only a few days of severe neutropenia and mucositis are related to development of early infections. However, no infection-related deaths were seen. Although Gram-positive organisms were the major cause of bacteremia, a glycopeptide in the empirical antibiotic regimen did not affect infection outcome. In PBPCT recipients, early and late opportunistic infections were notably absent, which was at variance with what was seen with bone marrow recipients. Efforts should be made to prevent mucositis and neutropenia and identify new strategies of antibacterial prophylaxis.  (+info)

Mental disturbances during isolation in bone marrow transplant patients with leukemia. (4/231)

The mental status of 39 leukemia patients, who received bone marrow transplants (BMT), was studied during the period of isolation. Mental disorders (diagnosed according to DSM-IV criteria) occurred in 16 patients (41%) during the observation period. The most frequent diagnoses were adjustment disorders, with anxiety and/or depression. Logistic regression analysis suggested higher Tension-Anxiety score in the Profile of Mood States (POMS) prior to isolation (P = 0.011), donation of the bone marrow from unrelated subjects (P = 0.026) and in female patients (P = 0.033). The results are preliminary, but indicate a high frequency of mental disturbances and highlight the importance of psychiatric intervention in BMT patients. Bone Marrow Transplantation (2000) 25, 315-318.  (+info)

Attempts to control clothes-borne infection in a burn unit, 2. Clothing routines in clinical use and the epidemiology of cross-colonization. (5/231)

Previous investigations have shown that cross-contamination in a burn unit is mainly clothes-borne. New barrier garments have been designed and tried experimentally. The aim of the present study was to investigate the effects of different clothing routines on cross-contamination. In a long-term study, the rates and routes of colonizations with Staphylococcus aureus, Streptococcus groups A, B, C, F, and G and Pseudomonas aeruginosa were examined. The exogenous colonization rates were, with S. aureus 77%, with Streptococcus species 52% and with Ps. aeruginosa 32%. The colonization rate with Ps. aeruginosa was higher in patients with larger burns. Patients dispersed Streptococcus and Ps. aeruginosa as well as S. aureus into the air of their rooms in considerable amounts, but dispersers were not more important as sources of cross-colonization than non-dispersers. In comparison of clothing routines, there was no difference in overall colonization rates. The newly designed barrier garment that was made from apparently particle-tight material did not reduce the transfer of bacteria from patient to patient. A less rigid routine than that previously used did not increase the risk of cross-contamination. A thorough change of barrier dress after close contact nursing delayed the first exogenous S. aureus colonization from day 6 to day 14 after admission. This routine might be recommended for clinical use. Otherwise, methods must be developed for adequate selection of materials intended for barrier garments.  (+info)

Risk of Cryptosporidium parvum transmission between hospital roommates. (6/231)

Patients with active diarrhea caused by infection with Cryptosporidium parvum can potentially contaminate the environment, which could serve as a risk for transmission to other patients in a hospital setting. A retrospective cohort study was performed to quantify the risk of nosocomial roommate-to-roommate transmission of Cryptosporidium and to evaluate the need for isolation of Cryptosporidium-infected patients. Thirty-seven human immunodeficiency virus (HIV)-infected roommates of 21 index patients with Cryptosporidium were identified between 1994 and 1996. Each exposed roommate (median CD4 cell count, 27cells/mm(3)) was matched to an HIV-infected, unexposed roommate with a similar CD4 cell count (median, 24 cells/mm(3)) who was present in the hospital during the same month but was not a roommate of a patient with Cryptosporidium infection. No patients with Cryptosporidium were identified among the 37 exposed roommates, and 1 case was identified among the 37 unexposed roommates. The risk ratio for chronic diarrhea was 0.80 (95% confidence interval [CI], 0.23-2.75) and for death was 1.04 (95% CI, 0.75-1.44). These results suggest that isolation of adult patients with Cryptosporidium diarrhea is not necessary to prevent roommate-to-roommate transmission of Cryptosporidium.  (+info)

The law, human rights, and the detention of individuals with tuberculosis in England and Wales. (7/231)

BACKGROUND: Tuberculosis poses a global public health threat, and individuals who fail to comply with treatment risk developing drug-resistant strains, which are a serious public health concern. A number of individuals who have been deemed to pose a 'serious risk of infection' to others have been detained in recent years in England and Wales under the Public Health Act 1984. With the incorporation of the European Convention on Human Rights (ECHR) into British law due to take effect shortly this paper examines the justness of Sections 37 and 38 of the Act, and asks whether the Act stands up to scrutiny under the ECHR. METHODS: A critical review, including an examination of recently opened relevant files at the Public Record Office, was carried out on Sections 37 and 38 of the Public Health Act 1984. RESULTS: Sections 37 and 38 of the Public Health Act 1984 fail to provide sufficient safeguards from abuse and fall short of the requirements of the ECHR. CONCLUSIONS: Sections 37 and 38 should be replaced. Greater safeguards to protect the rights of those with infectious diseases are needed.  (+info)

Risks and prevention of nosocomial transmission of rare zoonotic diseases. (8/231)

Americans are increasingly exposed to exotic zoonotic diseases through travel, contact with exotic pets, occupational exposure, and leisure pursuits. Appropriate isolation precautions are required to prevent nosocomial transmission of rare zoonotic diseases for which person-to-person transmission has been documented. This minireview provides guidelines for the isolation of patients and management of staff exposed to the following infectious diseases with documented person-to-person transmission: Andes hantavirus disease, anthrax, B virus infection, hemorrhagic fevers (due to Ebola, Marburg, Lassa, Crimean-Congo hemorrhagic fever, Argentine hemorrhagic fever, and Bolivian hemorrhagic fever viruses), monkeypox, plague, Q fever, and rabies. Several of these infections may also be encountered as bioterrorism hazards (i.e., anthrax, hemorrhagic fever viruses, plague, and Q fever). Adherence to recommended isolation precautions will allow for proper patient care while protecting the health care workers who provide care to patients with known or suspected zoonotic infections capable of nosocomial transmission.  (+info)

  • Designed to provide medical staff and first responders a safe means to isolate contaminated patients, and even transport them from one location to another, patient isolation systems shield and isolate the victims and protect the first responders. (
  • Serial DGU efficiently isolates plasma exosomes with distinct differences between GBM patients and normal donors, suggesting utility for non-invasive biomarker assessment. (
  • Thus, we studied the isolates from 79 patients with pityriasis versicolor, both from lesions and from apparently healthy skin close to the visible lesions. (
  • On the basis of the 120-kDa and VLPT genotypes, the cerebrospinal fluid and blood isolates from the same patients were identical. (
  • The deduced amino acid sequences of the V2 and V3 regions of gp120 were identical or very similar between the isolates obtained in the presence or absence of NA, suggesting that both isolation procedures selected a similar population. (
  • In patients with Candida bloodstream infections, prior antifungal therapy is an independent risk factor for fluconazole-nonsusceptible Candida isolates, including Candida krusei , C. glabrata , C. albicans , C. tropicalis , and C. parapsilosis ( 13 , 23 ). (
  • Both the isolates were recovered from BACTEC Plus Aerobic/F blood culture bottles of a candidemic patient. (
  • For isolation of MRSA isolates, bacterial suspensions were cultured on Muller-Hinton Agar containing NaCl and Oxacillin. (
  • The presence of MRSA isolates in the nasal cavity of HIV patients in such a rate warns us about the potential spreading of MRSA among HIV patients in our society and emphasizes on establishing better prevention strategies. (
  • The team, during their visit to the house, will also assess its suitability for self-isolation and will check if the requisite facility is available at the residence for quarantining family contacts. (
  • A signed undertaking on self-isolation and that all guidelines of home isolation will be followed will also be sought. (
  • According to the revised COVID-19 norms, the health ministry has made allowances for asymptomatic patients to quarantine at home as long as they have the requisite self-isolation facilities. (
  • According to the document, asymptomatic patients like the ones who are pre-symptomatic and have very mild symptoms can opt for home isolation if they have the requisite self-isolation facility at their residence so as to avoid contact with other family members. (
  • The patient also has to give an undertaking stating that being diagnosed as a confirmed/suspect case of COVID-19, he/she hereby voluntarily undertakes to maintain strict self-isolation at all times for the prescribed period, the guidelines said. (
  • For anyone who refuses to cooperate, actions can range from issuing a self-isolation order to "checking in once a day via the internet, to putting a tracking device on somebody, to placing an armed guard outside of their home," Katz said. (
  • CDC recommends keeping that person isolated until clinical and laboratory information, including acid-fast bacilli (AFB) smear testing of three sputum (mucus coughed up from the lungs) specimens, each collected eight to 24 hours apart, show that the patient is unlikely to have contagious TB. (
  • In this study, we isolated and phenotypically identified 108 yeast strains from various clinical specimens collected from 100 hospitalized patients at three tertiary hospitals in São Luís-Maranhão, Brazil, from July to December 2010. (
  • We obtained blood specimens from 27 febrile patients with a history of tick exposure. (
  • Immunological profile of the patients did not match accurately C.pneumoniae detection rate in serum specimens. (
  • Viable forms C. pneumoniae with typical electron microscopic structure can be identified and isolated from serum specimens of the patients with acute coronary syndrome and some healthy volunteers. (
  • Among the 38 patients enrolled, E. chaffeensis was isolated from the blood of 7 (18%) and from cerebrospinal fluid specimens of 2 of these 7. (
  • Here we report on a CF patient with repeated isolation of T. mycotoxinivorans in respiratory specimens during the past 9 years. (
  • Mucosal antral biopsy specimens were obtained from 136 consecutive dyspeptic patients diagnosed with peptic ulcer by endoscopy at Basra General Hospital, Iraq. (
  • Azoulay E, Cohen Y, Zahar JR, Garrouste-Orgeas M, Adrie C, Moine P, de lassence A, Timsit JF (2004) Practices in non-neutropenic ICU patients with Candida -positive airway specimens. (
  • From 147 CSF specimens, one S. pneumoniae strain was identified from a patient with bacterial meningitis symptoms. (
  • The aim of our study was to compare the capacity and performance of sheep blood agar, MacConkey agar and CHROMagar Acinetobacter for isolation and identification of A baumannii in tracheal aspirates specimens obtained from patients with Ventilator-associated pneumonia. (
  • Transcripts for the following cytokines were detected in patient specimens that also contained the IL-10-producing monocytes IL-2 (12 of 17 specimens), GM-CSF (9 of 17 specimens), IFN-γ (6 of 17 specimens), and TNF-α (4 of 17 specimens). (
  • IL-10 transcripts have been identified in RNA preparations from peritoneal exudate cells (PEC) present in ascitic fluid and from solid tumor specimens from patients with EOC ( 5 , 20 ). (
  • However, since this cell population was detected in most of the examined PEC specimens, these cells may have an important role in regulating tumor immunity in patients with EOC. (
  • In addition to routine steps to control infection, keeping babies who have candida in separate rooms (single room isolation) or cared for together (cohorting) may decrease the spread of candida. (
  • The review found no evidence to either support or refute the use of patient isolation measures (single room isolation or cohorting) in neonates with candida colonization or infection. (
  • Despite the evidence for transmission of candida by contact and evidence of cross-infection by health care workers, no standard policy of patient isolation measures beyond routine infection control measures exists in the neonatal unit. (
  • There is an urgent need to research the role of patient isolation measures for preventing transmission of candida in the neonatal unit. (
  • To determine the effect of patient isolation measures (single room isolation and/or cohorting) for infants with candida colonization or infection as an adjunct to routine infection control measures on the transmission of candida to other infants in the neonatal unit. (
  • Types of interventions: A policy of patient isolation measures (single room isolation or cohorting of infants with Candida colonization or infection) compared to routine isolation measures. (
  • Prior use of fluconazole is a modifiable risk factor for the isolation of fluconazole-nonsusceptible Candida species. (
  • The objective of this study was to evaluate the effects of prior fluconazole therapy, including the dose and duration, on fluconazole susceptibility among Candida species isolated from hospitalized patients with candidemia. (
  • The relationships between the initial dose and duration of prior fluconazole therapy and the isolation of fluconazole-nonsusceptible Candida species were assessed. (
  • Preexposure with an initial dose of fluconazole greater than 2 mg/kg and less than 6 mg/kg occurred in 3 of 9 (33%) and 8 of 9 (89%) patients with fluconazole-susceptible and fluconazole-nonsusceptible Candida species, respectively ( P , 0.0498). (
  • We conclude that patients with candidemia due to fluconazole-nonsusceptible Candida species were more likely to have received prior fluconazole therapy. (
  • The Infectious Diseases Society of America (IDSA) guidelines recommend an echinocandin antifungal over fluconazole for patients with a history of prior azole therapy due to a higher likelihood of isolation of fluconazole-nonsusceptible Candida species ( 15 ). (
  • The objective of this study was to evaluate an impact of prior fluconazole therapy on fluconazole susceptibility among Candida species responsible for the first occurrence of candidemia among hospitalized patients, with a specific focus on the dose and duration of prior fluconazole therapy. (
  • Here, we describe isolation of two cholesterol-dependent Candida glabrata strains from a candidemia patient which failed to grow on the media devoid of a cholesterol source. (
  • Candida glabrata has emerged as the second most important yeast associated with mucosal and systemic infections in critically ill patients in some tertiary care hospitals in North America [ 1 ]. (
  • Lodderomyces elongisporus is phenotypically closely related to Candida parapsilosis and has recently been identified as an infrequent cause of bloodstream infections in patients from Asia and Mexico. (
  • Molecular differentiation and antifungal susceptibilities of Candida parapsilosis isolated from patients with bloodstream infections. (
  • Large series on the incidence of histologically proven Candida pneumonia in intensive care unit (ICU) patients are lacking. (
  • We looked for differences in incidence in patients with and without respiratory samples positive for Candida species pre-mortem. (
  • In the other 58 patients with autopsy-proven pneumonia and no Candida isolation pre-mortem, no Candida pneumonia was observed either. (
  • Despite frequent isolation of Candida spp. (
  • from the airways, over a two-year period no single case of Candida pneumonia was found among the patients with evidence of pneumonia on autopsy. (
  • This study indicates that Candida pneumonia is an extremely rare occurrence in ICU patients and provides further evidence against the common use of antifungal therapy triggered by a microbiology report of Candida isolation from the respiratory tract. (
  • Isolation of tumor cells is accomplished using a bimolecular surface of E-selectin in addition to antibodies against epithelial markers. (
  • Because only the residual cancer cells outside the liver of a recipient can cause recurrence after liver transplantation in HCC patients, isolated tumor cells must be the source of recurrence ( 4 ). (
  • These results highlight a new signaling cascade initiated by tumor environment alterations leading to stem-cell features and poor patients' outcome. (
  • For a DC-based tumor therapy to be successful, DCs from cancer patients must be able to take up tumor-specific antigens and present these in an immunostimulatory fashion to immunologically competent T cells. (
  • Since this subset of monocytes could affect the modulation of tumor immune responses in vivo, studies were undertaken to determine their effect on the activation and proliferation of autologous T cells from the peritoneal cavity of patients with ovarian carcinoma. (
  • Tumor-infiltrating lymphocytes (TIL) in patients with EOC contain activated T cells, as characterized by the oligoclonal expansion of the TCR ( 4 ), production of IL-2 and IFN-γ transcripts ( 5 ), and the presence of early and late stage activation Ags ( 6 ). (
  • However, TIL in the ascitic fluid of EOC patients are frequently exposed to molecules produced in the tumor microenvironment that could inhibit a variety of functions associated with activation. (
  • The aim of this study was to assess common phenotypic features of nine tumor cell lines established from BM of patients with cancer of the prostate (four cell lines), breast (two cell lines), lung (two cell lines), and colon (one cell line) using immunocytochemistry, flow cytometry, and reverse transcription-PCR. (
  • For patients with epithelial tumors, which represent the majority of cancers in industrialized countries, the detection level of micrometastatic tumor cells is now improved. (
  • The husband of an American missionary diagnosed with the deadly Ebola virus has ended his quarantine in North Carolina and visited his wife Sunday at an isolation room at Emory University Hospital in Atlanta, a Christian missionary group announced Monday. (
  • MCUA showed a higher isolation rate than classic Columbia agar (67.6% versus 44.1% of patients), and the results were obtained faster (24 hours versus 5-7 days) with more clear-cut identification. (
  • This requires limiting the public interactions of possible or known SARS patients (e.g., at work, school, out-of-home child care) and preventing transmission wherever the patients are housed during the period of infectivity (10 days after the resolution of fever, provided respiratory symptoms are absent or improving). (
  • Close contacts of SARS patients (see footnote 1 ) should be vigilant for fever (i.e., measure temperature twice daily), respiratory symptoms, and other symptoms of early SARS-CoV disease, such as chills, rigors, myalgia, headache, or diarrhea. (
  • We identified 1506 patients isolated for respiratory illnesses and 745 patients isolated for MRSA. (
  • The test may make it possible for some patients to be released from hospital isolation sooner, freeing up limited medical resources and removing restrictions on patients' movements and interactions. (
  • For example, hospital isolation may be necessary if there are young children or high-risk adults in the home who can't leave for some reason, or if the patient is a resident of a congregate setting, such as a nursing home, correctional facility, or college dormitory. (
  • Three months after the index ablation, a second procedure was performed to confirm persistent isolation of PVs and CT block. (
  • TaqMan PCR analysis revealed that human serum of patients with acute coronary syndrome may contain genetic markers of C. pneumoniae with bacterial load range from 200 to 2000 copies/ml serum. (
  • Mississauga, Canada, 05/23/2017 - Results from a recent Lymphoma Coalition global patient survey indicate that concerns about body image, depression, and changes in relationships and have been major issues for lymphoma patients. (
  • Before a SARS patient is placed in a residence or community facility for isolation, arrangements should be made to ensure that the residence has the features necessary for provision of appropriate care to the patient and to determine if sufficient infection control measures can be established to prevent/limit exposures to household members, other primary caregivers, and the community. (
  • The SARS patient in home isolation and all persons in contact with the patient should follow the infection control recommendations described in Supplement I . (
  • Current CDC TB infection control guidelines recommend placing a patient suspected of having active TB in an airborne infection isolation room. (
  • We tested the hypothesis that computerized reminders from a centralized infection control expert system can improve rates of barrier isolation in patients with MDROs. (
  • As a precautionary measure, (we) put in heightened infection control measures in the emergency department including isolating the patient," the hospital said in a statement Saturday. (
  • Here, we report the development and validation of a unique magnetic cell separation system, which allows enumeration, immunomorphologic identification, and genetic analysis of CTCs from peripheral blood samples of HCC patients, mediated by the interaction of the asialoglycoprotein receptor exclusively expressed on hepatocytes with its ligand. (
  • We show the clinical course of a CF patient over 9 years as well as the applications of modern molecular and proteomic identification techniques of this rare fungus. (
  • Zhao L, Yu J, Wang J, Li H, Che J, Cao B. Isolation and Identification of miRNAs in exosomes derived from serum of colon cancer patients. (
  • Cette dernière a présenté un taux d'isolement plus élevé que la gélose Columbia classique (67,6 % des patients contre 44,1 %) et les résultats ont été obtenus plus rapidement (24 heures contre 5 à 7 jours), avec une identification plus nette. (
  • S. pneumoniae isolation and identification were performed using conventional culture and molecular tools. (
  • As a result, not all facilities have isolation rooms or have enough isolation rooms to handle an epidemic/pandemic. (
  • Combining this protective effect with the higher ventilation/filtration rate of the inner isolation zone (in comparison with the total room) yields a more rapid removal of airborne contaminant. (
  • The isolation protocol yields preferentially cells bigger than 8 μm enabling further cytomorphological and molecular analysis. (
  • Isolation of Dermatophytes and related species from Domestic Fowl ( Gallus gallus domesticus ). (
  • A single species was isolated from 660 patients: 150 members of the tuberculosis complex (146 M tuberculosis, two M bovis, and two M africanum), 356 M avium-intracellulare (MAI), and 154 other environmental mycobacteria. (
  • In the present study, we attempted to investigate the involvement of SAP gene in RA.Using a quantitative real-time polymerase chain reaction (PCR), the expression level of SAP transcripts in peripheral leukocytes or T cells was examined for patients with RA, systemic lupus erythematosus (SLE), palindromic RA, or chronic renal diseases, as well as normal individuals. (
  • Nucleotide sequence of SAP cDNAs obtained from peripheral leukocytes of RA patients was determined to examine any mutations. (
  • The expression level of SAP transcripts in peripheral leukocytes of 21 RA patients was significantly lower than that of 13 normal individuals (p=0.0007), 4 patients with palindromic RA, 11 with inactive SLE, or 17 with chronic renal diseases. (
  • The decreased expression of SAP transcripts in RA patients was also observed in peripheral CD2+ T cells compared with normal individuals. (
  • There was no mutation in the coding region of SAP cDNAs derived from peripheral leukocytes of 5 RA patients. (
  • The decreased expression of SAP transcripts in peripheral leukocytes or T cells of RA patients might lead to the failure of the immune system to eliminate the EBV-infected synovial lining cells in joints of RA patients. (
  • We conducted three-dimensional chemotaxis experiments to elucidate the effect of adenosine on the migration of peripheral blood CD8 + T cells from head and neck squamous cell carcinoma (HNSCC) patients. (
  • Amino acid compositions of HNC1β and EDC1, a glycoprotein previously isolated from the urine of a patient with acute myelocytic leukemia, are closely similar, while the carbohydrate compositions differ widely. (
  • Urine from patients with 11 types of disseminated cancer (ovary, breast, lung, colon, squamous head and neck, melanoma, acute and chronic leukemias of myelocytic, monocytic and lymphocytic varieties) contained 1.7 to 27 mg of HNC1β per g of creatinine. (
  • It involves the injection of ES cells, directed to an oligodendrocyte precursor cell lineage, into 10 patients with acute spinal cord injury within 10 days of injury. (
  • Altered homeostasis of Treg subpopulations in patients developing acute graft-versus-host disease. (
  • This analysis suggested a marked depletion of Treg with a naive phenotype in patients developing acute graft-versus-host disease, compared with tolerant patients. (
  • Prevalence of CTCs was examined in samples from HCC patients, healthy volunteers, and patients with benign liver diseases or non-HCC cancers. (
  • CTCs were identified in 69 of 85 (81%) HCC patients, with an average of 19 ± 24 CTCs per 5 mL. (
  • Our system provides a new tool allowing for highly sensitive and specific detection and genetic analysis of CTCs in HCC patients. (
  • Current strategies for detecting CTCs in HCC patients are limited to complex analytic approaches based on reverse transcriptase-PCR (RT-PCR), which can give inevitable false-positive and -negative results. (
  • Therefore, total RNA was isolated from blood samples of healthy donors and patients with primary or metastatic breast cancer after enrichment of mononuclear cells by density gradient centrifugation. (
  • analyzed the migration of CD8 + T cells in a 3D chemotaxis assay and found that adenosine inhibited the chemotaxis of T cells from cancer patients more than T cells from healthy donors. (
  • Using multiparameter single-cell analysis techniques, we explored the heterogeneity and functional diversity of human Tregs in healthy donors and in patients after allogeneic hematopoietic stem cell transplantation (alloHSCT). (
  • Together, the ventilated headboard and HEPA system can provide multiple isolation units or "surge isolation capacity" in traditional patient rooms, triage stations, emergency medical shelters, or even as emergency/temporary support options for displaced population shelters. (
  • During the period of home isolation, household members not providing care should be relocated if possible so that only the primary caregiver and the patient remain in the residence. (
  • On the other hand, circulating monoclonal immunoglobulins (IgM kappa or IgG lambda) were detected in a significant higher frequency (43%) of SS-HCV patients as compared with the primary SS patients [ 3 ]. (
  • The study aimed to develop a rapid and simple method for the primary isolation and detection of Helicobacter pylori from dyspeptic patients. (
  • 0.05 for both) in primary human skeletal muscle cell cultures established from patients with type 2 diabetes mellitus (n=5). (
  • L'objectif de cette étude était de mettre au point une méthode rapide et simple permettant d'isoler et de détecter Helicobacter pylori chez des patients dyspeptiques. (
  • Since the isolation of Helicobacter pylori by Marshall and Warren in 1983 , tremendous progress in the understanding of the etiology, pathogenesis and management of this disease has occurred. (
  • It is well established that larger social networks predict lower overall mortality in healthy populations and in breast cancer patients, but associations with breast cancer-specific outcomes like recurrence and breast cancer mortality have been mixed,' says Dr. Kroenke. (
  • While n-3 PUFAs have been suggested to limit adverse outcomes associated with inflammation, oxidative stress and disturbed antioxidant status, a deeper understanding of the therapeutic potential of these bioactive nutrients is required in patient populations with conditions characterised by inflammation and oxidative overload such as abdominal aortic aneurysm (AAA). (
  • New research suggests that social connections may also play a role in predicting survival rates among breast cancer patients. (
  • Overall, the correlations proved to be stronger in patients with stages 1 and 2 breast cancer. (
  • Patients with comorbid conditions like kidney diseases including patients on dialysis, heart diseases, stroke, tuberculosis, cancer , people living with HIV, immune-compromised, on steroids and immune-suppressants will not be allowed home isolation. (
  • However, immuno compromised patients (included HIV, transplant recipients, cancer therapy) are not eligible for home isolation, state the revised guidelines released on Thursday. (
  • The greatest negative change for patients during treatment is with isolation, and many HL patients find that quality of life issues are just as challenging as the physical effects of the cancer itself", stated Karen Van Rassel CEO, Lymphoma Coalition. (
  • Immortalised human taste bud cells, isolated from the fungiform tastebuds of patients with cancer of the mobile tongue. (
  • Recently, extracellular vesicles were proposed as excellent biomarkers for disease monitoring and prognosis in cancer patients. (
  • Bodey GP (1984) Candidiasis in cancer patients. (
  • The focus of the presented work is on detecting differences in gene expression between healthy individuals and adjuvant and metastatic breast cancer patients, not an accurate quantification of these differences. (
  • A newly described subset of monocytes has been identified in peritoneal exudate cells (PEC) from the malignant ascites from patients with ovarian cancer. (
  • The program focuses on improving the health of cancer patients and cancer survivors by providing comprehensive cardiac and vascular care. (
  • Onik treated the first liver patients with cryosurgery in 1986 and the first patient with ultrasound guided prostate cryosurgery in 1990, and has developed techniques and instrumentation that have been integral to the minimally invasive treatment of cancer. (
  • In 1982, using cryosurgical ablation under ultrasound guidance he developed the first new potentially curative treatment for unresectable liver cancer patients. (
  • Dr Onik developed the instrumentation and techniques that allowed for the cryosurgical ablation of prostate cancer, which is now an accepted alternative to radiation and radical prostatectomy and the preferred treatment for patients with prostate cancer who have failed radiation therapy. (
  • The concepts and techniques he developed have had a major impact on the treatment of cancer patients throughout the world and his work has been recognized by awards given to him by major societies in both medicine and engineering. (
  • Persons at risk for serious SARS complications (e.g., persons with underlying heart or lung disease, persons with diabetes mellitus, elderly persons) should not have contact with the patient. (
  • Elderly patients aged above 60 years and those with co-morbid conditions such as hypertension, diabetes, heart disease, chronic lung/liver/kidney disease and cerebro-vascular disease among others shall only be allowed home isolation after proper evaluation by the treating medical officer. (
  • Separate and confine patients who meet the case definition for probable or confirmed SARS-CoV disease or SARS report under investigation (RUI) during the period of communicability (see MMWR 52(49):1202-1206 ). (
  • This appears to be the first report on isolation of cholesterol-dependent strains of C. glabrata from a candidemia patient exhibiting resistance to azoles and amphotericin B. Further, the report demonstrates that induction of cholesterol/sterol auxotrophy is associated with resistance to antifungal drugs targeting ergosterol biosynthesis. (
  • We report here the isolation of Lodderomyces elongisporus from the catheter of a suspected case of fungemia. (
  • This is the first report of the isolation of Nocardia thailandica from Iran. (
  • First Report of the Isolation of Nocardia thailandica from the Bronchoalveolar Lavage of a Patient in Iran', Iranian Journal of Medical Sciences , 43(5), pp. 560-563. (
  • Staff must report events that harm or have the potential to seriously harm a patient. (
  • Therefore, the main goal of this study was to determine the prevalence rate of MRSA carriage rate among HIV patients referring to the Shiraz HIV referral center (Shiraz, Iran) during 2011-2012. (
  • Glioma patients' and normal donors' plasma exosomes underwent brief centrifugation to remove cells/debris followed by serial density gradient ultracentrifugation (DGU). (
  • Wild type isocitrate dehydrogenase glioma patients' (i.e., more aggressive tumors) plasma exosomes are smaller but higher concentration than normal donors. (
  • Surprisingly, immunosuppressive programmed death-ligand 1 (PD-L1) is present in both patients' and normal donors' exosomes. (