Pathology. Medical search

A specialty concerned with the nature and cause of disease as expressed by changes in cellular or tissue structure and function caused by the disease process.

A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)

A field of anatomical pathology in which living tissue is surgically removed for the purpose of diagnosis and treatment.

Hospital department which administers and provides pathology services.

A dental specialty concerned with pathology of the oral cavity.

A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

A subspecialty of pathology concerned with the molecular basis (e.g., mutations) of various diseases.

The field of veterinary medicine concerned with the causes of and changes produced in the body by disease.

Transmission and interpretation of tissue specimens via remote telecommunication, generally for the purpose of diagnosis or consultation but may also be used for continuing education.

Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).

Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease.

The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.

The study of speech or language disorders and their diagnosis and correction.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.

Accumulations of extracellularly deposited AMYLOID FIBRILS within tissues.

The application of pathology to questions of law.

Postmortem examination of the body.

Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE; DEMENTIA; PARKINSONIAN DISORDERS; progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE); and corticobasal degeneration.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.

A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.

Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.

Elements of limited time intervals, contributing to particular results or situations.

Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.

The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.

A synuclein that is a major component of LEWY BODIES that plays a role in neurodegeneration and neuroprotection.

The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.

A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)

Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.

Tomography using x-ray transmission and a computer algorithm to reconstruct the image.

Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.

A generic term for any circumscribed mass of foreign (e.g., lead or viruses) or metabolically inactive materials (e.g., ceroid or MALLORY BODIES), within the cytoplasm or nucleus of a cell. Inclusion bodies are in cells infected with certain filtrable viruses, observed especially in nerve, epithelial, or endothelial cells. (Stedman, 25th ed)

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)

Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.

The production of a dense fibrous network of neuroglia; includes astrocytosis, which is a proliferation of astrocytes in the area of a degenerative lesion.

An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.

The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

Diseases involving the FALLOPIAN TUBES including neoplasms (FALLOPIAN TUBE NEOPLASMS); SALPINGITIS; tubo-ovarian abscess; and blockage.

A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.

A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.

A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.

Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.

Clinical syndrome describing overuse tendon injuries characterized by a combination of PAIN, diffuse or localized swelling, and impaired performance. Distinguishing tendinosis from tendinitis is clinically difficult and can be made only after histopathological examination.

The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe.

Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.

Hospital facilities equipped to carry out investigative procedures.

Methods of preparing tissue for examination and study of the origin, structure, function, or pathology.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.

Incorrect diagnoses after clinical examination or technical diagnostic procedures.

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

Radiography of the uterus and fallopian tubes after the injection of a contrast medium.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

The study of infectious diseases associated with plants.

Centers for acquiring, characterizing, and storing organs or tissue for future use.

A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).

In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.

A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.

An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)

A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.

Pathological processes involving any part of the UTERUS.

The measurement of an organ in volume, mass, or heaviness.

Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)

Species of CHLAMYDIA causing pneumonitis in mice and hamsters. These isolates formerly belonged to CHLAMYDIA TRACHOMATIS.

Mice bearing mutant genes which are phenotypically expressed in the animals.

Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)

Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.

Time period from 1801 through 1900 of the common era.

Infections of the genital tract in females or males. They can be caused by endogenous, iatrogenic, or sexually transmitted organisms.

A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.

The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.

A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.

Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.

Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.

An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.

The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

The technique of using FIXATIVES in the preparation of cytologic, histologic, or pathologic specimens for the purpose of maintaining the existing form and structure of all the constituent elements.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

An encapsulated lymphatic organ through which venous blood filters.

Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.

A characteristic symptom complex.

Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.

Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

Discrete abnormal tissue masses that protrude into the lumen of the DIGESTIVE TRACT or the RESPIRATORY TRACT. Polyps can be spheroidal, hemispheroidal, or irregular mound-shaped structures attached to the MUCOUS MEMBRANE of the lumen wall either by a stalk, pedunculus, or by a broad base.

The most common clinical form of FRONTOTEMPORAL LOBAR DEGENERATION, this dementia presents with personality and behavioral changes often associated with disinhibition, apathy, and lack of insight.

An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.

The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.

Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.

Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.

Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.

They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.

Tumors or cancer of the human BREAST.

Endoscopic examination, therapy or surgery of the interior of the uterus.

Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.

Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.

The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.

Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.

Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.

Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.

Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.

Diseases affecting the eye.

The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.

Time period from 1901 through 2000 of the common era.

Established cell cultures that have the potential to propagate indefinitely.

Physiological changes that occur in bodies after death.

Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.

Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.

Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.

Thinly cut sections of frozen tissue specimens prepared with a cryostat or freezing microtome.

The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.

A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)

Learning the correct route through a maze to obtain reinforcement. It is used for human or animal populations. (Thesaurus of Psychological Index Terms, 6th ed)

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

The number of CELLS of a specific kind, usually measured per unit volume or area of sample.

The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.

Disease having a short and relatively severe course.

Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.

The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).

Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.

Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.

Pathological processes of the KIDNEY or its component tissues.

The delicate interlacing threads, formed by aggregations of neurofilaments and neurotubules, coursing through the CYTOPLASM of the body of a NEURON and extending from one DENDRITE into another or into the AXON.

A major deviation from normal patterns of behavior.

The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.

An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.

A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.

Capacity that enables an individual to cope with and/or recover from the impact of a neural injury or a psychotic episode.

An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.

Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.

Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.

The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

A malignant epithelial tumor with a glandular organization.

Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).

The observable response an animal makes to any situation.

A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.

Schistosomiasis caused by Schistosoma mansoni. It is endemic in Africa, the Middle East, South America, and the Caribbean and affects mainly the bowel, spleen, and liver.

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown.

The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.

Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.

The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.

The study of hearing and hearing impairment.

Pathological processes of the LIVER.

An infant during the first month after birth.

Diseases of Old World and New World monkeys. This term includes diseases of baboons but not of chimpanzees or gorillas (= APE DISEASES).

A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.

An assessment of the operation of an external quality assessment (EQA) scheme in histopathology in the South Thames (West) region: 1995-1998. (1/578)

AIMS: To describe the design and organisation of a voluntary regional external quality assessment (EQA) scheme in histopathology, and to record the results obtained over a three year period. METHODS: A protocol is presented in which circulation of EQA slides alternated with teaching sessions. Procedures for the choice of suitable cases, evaluation of submitted diagnoses, and feedback of results to participants are described. The use of teaching sessions, complementary to the slide circulations, and dealing with current diagnostic problems is also outlined. RESULTS: Participation rates in the nine slide circulations varied between 66% and 89%, mean 85%. Overall scores were predictably high but 4% of returns, from 10 pathologists, were unsatisfactory. These low scores were typically isolated or intermittent and none of the participants fulfilled agreed criteria for chronic poor performers. CONCLUSIONS: This scheme has been well supported and overall performances have been satisfactory. The design was sufficiently discriminatory to reveal a few low scores which are analysed in detail. Prompt feedback of results to participants with identification of all "incomplete" and "wrong" diagnoses is essential. Involvement of local histopathologists in designing, running, and monitoring such schemes is important. (+info)

The efficacy and limitations of repeated slide conferences for improving interobserver agreement when judging nuclear atypia of breast cancer. The Japan National Surgical Adjuvant Study of Breast Cancer (NSAS-BC) Pathology Section. (2/578)

BACKGROUND: The pathology section of the Japan National Surgical Adjuvant Study of Breast Cancer protocol study was set up to establish histological criteria for assessing high-risk node-negative breast cancers and standardize the subjective criteria used by collaborating pathologists for nuclear grading of cancers. METHODS: In order to standardize the nuclear atypia criteria, five slide conferences were held. A total of 57 observers assigned nuclear atypia scores to 119 breast carcinomas that were presented using a slide projector or a TV monitor and discussed their histological findings. The percentage interobserver agreements per tumor and per conference and kappa value per conference were estimated and compared among the conferences. The percentage intraobserver reproducibility per tumor between the last two conferences was compared with the percentage interobserver agreement for 20 tumors. The kappa value was also calculated for each of 27 observers to evaluate scoring reproducibility. RESULTS: The percentage interobserver agreement per conference was constant (75-78%) throughout the five meetings and the rate of tumors with > 80% agreement per tumor became higher in later conferences. The kappa value was 0.42, 0.25, 0.42, 0.51 and 0.50 for the first, second, third, fourth and fifth conferences, respectively. The tumors with a lower percentage interobserver agreement also had a lower percentage intraobserver reproducibility and such scoring variations were attributed to the intermediate nature of the degree of tumor atypia. In 26 of 27 observers, intraobserver agreement for 20 tumors was estimated from the kappa value to range from moderate to almost perfect. CONCLUSION: We concluded that the repeated slide conferences conducted by the pathology section were an effective means of standardizing the subjective histopathological criteria used to assess tumors. However, the achievement of a good scoring agreement would be difficult for tumors with an intermediate degree of atypia. (+info)

Attracting and training more chemical pathologists in the United Kingdom. (3/578)

I have attempted to define the function of the medical graduate in the clinical biochemistry laboratory and have examined data on recrutiment in the United Kingdom into clinical biochemistry. If trainee pathologists were encouraged to become proficient in both a branch of clinical medicine and in research techniques, the resulting chemical pathologists should be able to improve the consultative and investigative functions of the laboratory. To this end I have suggested some changes in the training regulations and in the role of the chemical pathologists. (+info)

The pathologist and toxicologist in pharmaceutical product discovery. (4/578)

Significant change is occurring in the drug discovery paradigm; many companies are utilizing dedicated groups from the toxicology/ pathology disciplines to support early stage activities. The goal is to improve the efficiency of the discovery process for selecting a successful clinical candidate. Toxicity can be predicted by leveraging molecular techniques via rapid high-throughput, low-resource in vitro and in vivo test systems. Several important activities help create a platform to support rapid development of a new molecular entity. The proceedings of this symposium provide excellent examples of these applied concepts in pharmaceutical research and development. Leading biopharmaceutical companies recognize that a competitive advantage can be maintained via rapid characterization of animal models, the cellular identification of therapeutic targets, and improved sensitivity of efficacy assessment. The participation of the molecular pathologist in this quest is evolving rapidly, as evidenced by the growing number of pathologists that interact with drug discovery organizations. (+info)

Mechanisms of disease and injury: utilization of mutants, monoclonals, and molecular methods. (5/578)

Rapid advances in our ability to localize and quantify macromolecular changes in health and disease are being brought about by the availability of genetically altered animals (mutants), purified reagents such as monoclonal antibodies, and new molecular methods. Targeted gene deletion (knockouts) and gene insertions (transgenics) in animals can allow identification of the importance and function of macromolecules. Monoclonal antibodies and fluorescent labels coupled with advances in microscopy provide exacting and multi-dimensional information about localization and cellular changes in proteins, carbohydrates, and lipids using immunohistochemistry, fluorescent activated cell sorting, and immunoprecipitation. Similarly, new applications of molecular methods can be used to identify and localize nucleic acids in tissues via in situ hybridization, polymerase chain reaction (PCR), reverse transcription (RT) PCR, differential display RT-PCR, RNase protection assays, and microchip arrays. The ligand for CD40 (CD40L), an important immunoregulatory molecule, is an example of the successful application of mutants, monoclonal antibodies, and molecular methods to cloning and biological characterization of new molecules. CD40L knockout mice, monoclonal antibodies, and several molecular methods were used to identify mutations in CD40L as the genetic basis for hyper-IgM syndrome in humans, to provide new insights into the pathobiology of Pneumocystis carinii infection, and to evaluate CD40L for immunotherapy of tumors and opportunistic infections. (+info)

Computer-based teaching of pathology at the Zagreb University School of Medicine. (6/578)

AIM: To review the experience gained in transferring USA computer-based teaching system of medical school pathology to Croatia. METHODS: Computer-based teaching program of pathology developed at the University of Kansas School of Medicine, Kansas City, Kansas, USA, was transferred to the University of Zagreb School of Medicine, Zagreb, Croatia. The experimental group of 49 students was enrolled into this computer-based program. Their performance was compared with that of 195 classmates enrolled in the standard course. Objective (performance on the examinations) and subjective data (students' interviews and written evaluations of the course) were analyzed. RESULTS: The computer program was operational 5 months from the inception of the transfer. It was well received by the students, even though many initially complained that it required more effort and a continuous commitment. The major problems concerned scheduling, reflecting various requirements i mposed on students by other departments teaching in parallel with the Pathology course. Objective data gathered so far indicate that the students enrolled in the computer-based program took the first midterm examination at a significantly higher rate than the rest of the class (p<0.001), and passed the examination with significantly better grades (p<0.001). CONCLUSION: Computer-based teaching programs can be readily transferred to other countries. Full implementation of the program, however, may require significant changes in the existing curriculum in the medical school to which such a program has been transferred or considerable modifications in the program adopted for transfer. It appears that the students enrolled in the computer-based program perform better than students in the standard pathology course. (+info)

A century of pathology at Yale: personal reflections. (7/578)

This history is largely about the players on the stage of the Yale Pathology Department acting out their roles as observed by the author in over a half century as a member of the department and as associate dean of the medical school. (+info)

An evaluation of the Banff classification of early renal allograft biopsies and correlation with outcome. (8/578)

BACKGROUND: The Banff classification for assessment of renal allograft biopsies was introduced as a standardized international classification of renal allograft pathology and acute rejection. Subsequent debate and evaluation studies have attempted to develop and refine the classification. A recent alternative classification, known as the National Institutes of Health Collaborative Clinical Trials in Transplantation (NIH-CCTT) classification, proposed three distinct types of acute rejection. The 1997 Fourth Banff meeting appeared to move towards a consensus for describing transplant biopsies, which incorporated both approaches. Patients who received a renal allograft at the Oxford Transplant Centre were managed by a combination of protocol and clinically indicated biopsies. We have undertaken a retrospective analysis of the biopsies correlated with the clinical outcome to test the prognostic value of the original Banff (Banff 93-95) and NIH-CCTT classifications. METHODS: Three hundred and eighty-two patients received renal allografts between May 1985 and December 1989, and were immunosuppressed using a standard protocol of cyclosporine, azathioprine and steroid. Adequate 5-year follow-up data were available on 351 patients, and of these, 293 had at least one satisfactory biopsy taken between days 2 and 35 after transplantation, the latter patients forming the study group. The D2-35 biopsies taken from these patients, which were not originally reported according to the Banff classification, were re-examined and classified according to the Banff 93-95 protocols. For each patient the biopsy found to be the most severely abnormal was selected, and the Banff and NIH-CCTT grading compared with the clinical outcome. RESULTS: Seven hundred and forty-three biopsies taken from 293 patients between days 2 and 35 after transplantation were examined and the patients categorized on the basis of the 'worst' Banff grading as follows. Normal or non-rejection, 20%; borderline, 34%; acute rejection grade I (AR I), 18%; AR IIA, 6%; AR IIB, 14%; AR III, 1%; AR IIIC, 3%; widespread necrosis 3%. The clinical outcome for the last two groups combined was very poor with 18% of grafts functioning at 3 months and 6% at 5 years. The other groups with vascular rejection (AR IIB and AR III) had an intermediate outcome, graft survival being 78% at 3 months and 61% at 5 years. The remaining four groups (normal, borderline, cellular AR I and AR IIA) had the best outcome: graft survival 95% at 3 months and 78% at 5 years with virtually no difference between the four groups. Three forms of acute rejection, namely tubulo-interstitial, vascular and transmural vascular, were identified, but only the latter two categories were associated with a poor outcome. CONCLUSIONS: The eight sub-categories of the Banff classification of renal allograft biopsies are associated with three different prognoses with respect to graft survival in the medium term. These three prognostic groups correspond to the three NIH-CCTT types. The data provide support for the consensus developed at Banff 97 separating tubulo-interstitial, vascular and transmural vascular rejection (types I, II and III acute rejection). (+info)

Anatomical pathology is one of two main divisions of the medical practice of pathology, the other being clinical pathology, the ... In France, pathology is separated into two distinct specialties, anatomical pathology, and clinical pathology. Residencies for ... American Society for Clinical Pathology (ASCP) American Society for Investigative Pathology (ASIP) Pathpedia online pathology ... oral pathology), as well as on the basis of the focus of the examination (as with forensic pathology). Pathology is a ...

https://en.wikipedia.org/wiki/Pathology

"Pathology Education: Cardiovascular". "eMedicine/Stedman Medical Dictionary Lookup!". Archived from the original on 2008-02-16 ...

https://en.wikipedia.org/wiki/Vegetation_(pathology)

... the British Society of Toxicological Pathology, and the European Society of Toxicologic Pathology. The journal is abstracted ... Toxicologic Pathology is a peer-reviewed academic journalcovering the field of toxicology. The editor-in-chief is Kevin A. ... "Toxicologic Pathology". 2018 Journal Citation Reports. Web of Science (Science OR Social Sciences ed.). Clarivate Analytics. ... Official website Society of Toxicologic Pathology (Articles with short description, Short description is different from ...

https://en.wikipedia.org/wiki/Toxicologic_Pathology

A corn or clavus (plural clavi or clavuses) is a cone-shaped and often painful inwardly directed callus of dead skin that forms at a pressure point near a bone, or on a weight-bearing part of the body. When on the feet, corns can be so painful as to interfere with walking. The visible portion of the corn tends to be more-or-less round, but corns are defined by having a hard tapering root that is directed inward, and pressure on the corn pushes this root deeper into the flesh. (Thus the Latin term clavus 'nail'.) Pressure corns usually occur on thin or glabrous (hairless and smooth) skin surfaces, especially on the dorsal surface of toes or fingers, but corns triggered by an acute injury (such as a thorn) may occur on the thicker skin of the palms or bottom of the feet (palmar corns and plantar corns). Pressure corns form when chronic pressure on the skin against an underlying bone traces a usually elliptical path during the rubbing motion. The corn forms at the center of the pressure point and ...

https://en.wikipedia.org/wiki/Corn_(pathology)

"Pathology to Enter Studio This Summer". Blabbermouth.net. May 25, 2011. Retrieved January 1, 2011. [1] via Pathology Official ... Pathology is an American death metal band from San Diego, California, formed in 2006 by drummer Dave Astor (previously with The ... In May 2011, it was announced that Pathology would enter Lambesis Studios that summer with producer Daniel Castleman to begin ... After a successful $4,000 Kickstarter campaign, Pathology released their eighth full-length album Throne of Reign on August 5, ...

https://en.wikipedia.org/wiki/Pathology_(band)

Anatomical pathology Cytopathology Histology Medical laboratory Microscopy Pathology Surgical pathology Telepathology Virtual ... Digital pathology is a sub-field of pathology that focuses on data management based on information generated from digitized ... A White Paper from the Digital Pathology Association". Journal of Pathology Informatics. 10: 9. doi:10.4103/jpi.jpi_82_18. ISSN ... "Digital Microscopy Imaging and New Approaches in Toxicologic Pathology". Toxicologic Pathology. 32 (5): 49-58. doi:10.1080/ ...

https://en.wikipedia.org/wiki/Digital_pathology

... , also known as bone pathology is a subspecialty of surgical pathology which deals with the diagnosis and ... Pathology of the Bones and Joints", Pathology: The Big Picture, The McGraw-Hill Companies, retrieved 2020-04-23 "General ... The field of orthopaedic pathology stretches to household pets, mainly in cats and dogs, due to their susceptibility to ... physical removal of fluid around joints to confirm either degenerative or inflammatory arthritis Practical Orthopedic Pathology ...

https://en.wikipedia.org/wiki/Orthopedic_pathology

... is pathology that focuses on determining the cause of death by examining a corpse. A post mortem examination ... Forensic pathology was first recognized in the United States by the American Board of Pathology in 1959 after toxicology and ... "History of Forensic Pathology". Retrieved 2022-03-05. Lett D (July 2007). "National standards for forensic pathology training ... The third is to complete a minimum 5 years' training in anatomical pathology to qualify as a fellow in anatomical pathology, ...

https://en.wikipedia.org/wiki/Forensic_pathology

v t e (Gross pathology, All stub articles, Pathology stubs). ... In pathology, diastasis is the separation of parts of the body ... Knight's Forensic Pathology. CRC Press. pp. 188-. ISBN 978-0-340-76044-4. Retrieved 2013-08-06. ...

https://en.wikipedia.org/wiki/Diastasis_(pathology)

... shares some aspects of practice with both anatomic pathology and clinical pathology, molecular biology, ... Molecular pathology is an emerging discipline within pathology which is focused in the study and diagnosis of disease through ... Molecular pathology is commonly used in diagnosis of cancer and infectious diseases. Techniques are numerous but include ... Integration of "molecular pathology" and "epidemiology" led to an interdisciplinary field, termed "molecular pathological ...

https://en.wikipedia.org/wiki/Molecular_pathology

... is a monthly peer-reviewed medical journal covering pathology in humans. It was established in 1970 and is ... "Human Pathology". 2016 Journal Citation Reports. Web of Science (Science ed.). Clarivate Analytics. 2016. Official website v t ... Pathology journals, Publications established in 1970, All stub articles, Medical journal stubs). ...

https://en.wikipedia.org/wiki/Human_Pathology

Like medical pathology, veterinary pathology is divided into two branches, anatomical pathology and clinical pathology. Other ... microscopic pathology, veterinary pathology, and general pathology. Only the general pathology section is shared between the ... Anatomical pathology (Commonwealth) or Anatomic pathology (U.S.) is concerned with the diagnosis of disease based on the gross ... Veterinary medicine "What is veterinary pathology?". American College of Veterinary Pathology. Archived from the original on ...

https://en.wikipedia.org/wiki/Veterinary_pathology

It is a subfield of forestry and plant pathology. Forest pathology is part of the broader approach of forest protection. ... Shade Tree Pathology Forest pathology team at INRA Nancy, France Hazard Trees (Articles with short description, Short ... Forest pathology is the research of both biotic and abiotic maladies affecting the health of a forest ecosystem, primarily ... Tainter, Frank H., and Fred A. Baker . Principles of Forest Pathology. New York, NY: John Wiley & Sons, Inc., 1996. European ...

https://en.wikipedia.org/wiki/Forest_pathology

... is one of the two major divisions of pathology, the other being anatomical pathology. Often, pathologists ... Pathology Medical laboratory Anatomic pathology Medical technologist Veterinary pathology Clinical Biologist "Textes Généraux, ... a combination sometimes known as general pathology. Similar specialties exist in veterinary pathology. Clinical pathology is ... Many areas of clinical pathology overlap with anatomic pathology. Both can serve as medical directors of CLIA certified ...

https://en.wikipedia.org/wiki/Clinical_pathology

... refers to macroscopic manifestations of disease in organs, tissues, and body cavities. The term is commonly ...

https://en.wikipedia.org/wiki/Gross_pathology

"Gynecologic Pathology Fellowship". "Selective Gynecologic Pathology Fellowship". v t e v t e (Anatomical pathology, Gynaecology ... Gynecologic pathology is the medical pathology subspecialty dealing with the study and diagnosis of disease involving the ... Gynecological pathology, including diseases of the female genital tract and the placenta Anatomic pathology Cytopathology " ... Fellowship training in surgical pathology or gynecologic pathology are additional credentials toward a career as a ...

https://en.wikipedia.org/wiki/Gynecologic_pathology

... , also known as investigative pathology is the scientific study of disease processes through the ... American Society for Investigative Pathology v t e Experimental pathology is the scientific study of disease processes through ... Articles with short description, Short description matches Wikidata, All stub articles, Pathology stubs, Pathology). ... It is closely related, both historically and in modern academic settings, to the medical field of pathology. ...

https://en.wikipedia.org/wiki/Experimental_pathology

... is any condition of the teeth that can be congenital or acquired. Sometimes a congenital tooth diseases are ... Tooth pathology is usually separated from other types of dental issues, including enamel hypoplasia and tooth wear. Anodontia ... Medicine portal Oral medicine Oral and maxillofacial pathology Tongue disease "Cavities/tooth decay". Mayo Clinic. Retrieved ...

https://en.wikipedia.org/wiki/Tooth_pathology

Pathology Digital pathology and Telepathology Clinical pathology Forensic pathology Laser capture microdissection List of ... online Pathology resources (in German) Pathology Outlines, an online textbook of anatomic pathology College of American ... Anatomical pathology is one of two branches of pathology, the other being clinical pathology, the diagnosis of disease through ... a combination known as general pathology. Similar specialties exist in veterinary pathology. Anatomic pathology relates to the ...

https://en.wikipedia.org/wiki/Anatomical_pathology

... is a bimonthly peer-reviewed medical journal devoted entirely to diagnostic ultrastructural pathology ... "Ultrastructural Pathology". 2016 Journal Citation Reports. Web of Science (Social Sciences ed.). Thomson Reuters. 2017. ... Pathology journals, Publications established in 1980, Bimonthly journals, Taylor & Francis academic journals, English-language ...

https://en.wikipedia.org/wiki/Ultrastructural_Pathology

Pulmonary pathology Renal pathology Soft tissue pathology Breast pathology Anatomical pathology Digital pathology and ... Endocrine pathology Gastrointestinal pathology Genitourinary pathology Gynecologic pathology Head and Neck pathology ... Commonly recognized subspecialties of surgical pathology include the following: Bone pathology Cardiac pathology Cytopathology ... Ophthalmic pathology Pediatric pathology (A board-certifiable subspecialty in the U.S. and a recognised specialty in the U.K.) ...

https://en.wikipedia.org/wiki/Surgical_pathology

... refers to enduring patterns of cognition, emotion, and behavior that negatively affect a person's ...

https://en.wikipedia.org/wiki/Personality_pathology

... is the medical journal of the International Society of Neuropathology, published for them by John Wiley & Sons ... "Brain Pathology". 2020 Journal Citation Reports. Web of Science (Science/Social Sciences ed.). Clarivate Analytics. 2021. ...

https://en.wikipedia.org/wiki/Brain_Pathology

2014 Pathology at IMDb Pathology at Rotten Tomatoes Pathology at Metacritic Pathology at Box Office Mojo Pathology at AllMovie ... The soundtrack to Pathology was released on April 29, 2008. "Pathology (2008) - Release dates". Internet Movie Database. ... "Pathology Movie Reviews, Pictures - Rotten Tomatoes". Rotten Tomatoes. Retrieved 2012-12-08. "Pathology (2008): Reviews". ... Pathology is a 2008 crime-horror film directed by Marc Schölermann, written by Mark Neveldine and Brian Taylor, and starring ...

https://en.wikipedia.org/wiki/Pathology_(film)

... is the subspecialty of surgical pathology which deals with the diagnosis and characterization of ... Fellowship in gastrointestinal pathology involves: diagnostic evaluation of surgical (whole organ) and biopsy pathology of ... During the course of a one-year gastrointestinal pathology fellowship, the GI-liver pathology fellow will review between 8,000 ... completed an accredited residency in pathology and is board certified in Anatomic Pathology by the American Board of Pathology ...

https://en.wikipedia.org/wiki/Gastrointestinal_pathology

... is a subspecialty of anatomic pathology that deals with the diagnosis and characterization of medical diseases ... http://www.renalpathsoc.org/ Renal Pathology Tutorial written by J. Charles Jennette Pathologist Guide v t e (Articles lacking ... in-text citations from September 2009, All articles lacking in-text citations, All stub articles, Pathology stubs, Anatomical ...

https://en.wikipedia.org/wiki/Renal_pathology

... Retrieved 4 December 2019. SA Pathology Centre for Cancer Biology Hanson Institute 34°55′21″S 138°35′57″E / ... Profits generated from pathology are used to support rural communities, medical training and medical research. SA Pathology has ... As a not-for-profit organisation, SA Pathology bulk-bills patients for all Medical Benefits Schedule (MBS) pathology tests. In ... SA Pathology bulk-bills patients for all Medical Benefits Schedule (MBS) pathology tests. In a recent article by Choice ...

https://en.wikipedia.org/wiki/SA_Pathology

A gumma (plural gummata or gummas) is a soft, non-cancerous growth resulting from the tertiary stage of syphilis (and yaws). It is a form of granuloma. Gummas are most commonly found in the liver (gumma hepatis), but can also be found in brain, heart, skin, bone, testis, and other tissues, leading to a variety of potential problems including neurological disorders or heart valve disease. Gummas have a firm, necrotic center surrounded by inflamed tissue, which forms an amorphous proteinaceous mass. The center may become partly hyalinized. These central regions begin to die through coagulative necrosis, though they also retain some of the structural characteristics of previously normal tissues, enabling a distinction from the granulomas of tuberculosis where caseous necrosis obliterates preexisting structures. Other histological features of gummas include an intervening zone containing epithelioid cells with indistinct borders and multinucleated giant cells, and a peripheral zone of fibroblasts ...

https://en.wikipedia.org/wiki/Gumma_(pathology)

Look up pathology in Wiktionary, the free dictionary. Pathology is a medical field specializing in the categorization of ... Pathology may also refer to: Anatomic pathology, the study of macro and microscopic abnormalities in tissues and cells. ... a 2005 video game Pathology (film), a 2008 film This disambiguation page lists articles associated with the title Pathology. If ... Clinical pathology, medical specialty that is concerned with the diagnosis of disease based on the laboratory analysis of ...

https://en.wikipedia.org/wiki/Pathology_(disambiguation)

p. 39, Table 2 International Society for Plant Pathology Australasian Plant Pathology Society American Phytopathological ... Grape Virology Opportunity in Plant Pathology Facebook page for Asian Association of Societies for Plant Pathology The Pest and ... "The Top 10 oomycete pathogens in molecular plant pathology" (PDF). Molecular Plant Pathology. 16 (4): 413-34. doi:10.1111/mpp. ... European Journal of Plant Pathology. European Foundation for Plant Pathology (Springer). 116 (1): 1-19. doi:10.1007/s10658-006- ...

https://en.wikipedia.org/wiki/Plant_pathology

... cardiovascular pathology services offer expert on-site cardiac biopsy interpretation, as well as dissection of explanted hearts ... Cardiac Pathology Services. Cardiac / cardiovascular pathology services offers expert on-site cardiac biopsy interpretation, as ... A surgical pathology accession sheet with adequate clinical history and differential diagnosis must accompany the specimen for ... Division of Pathology and Laboratory Medicine. Cincinnati Childrens Hospital Medical Center. 3333 Burnet Avenue, MLC1035. ...

https://www.cincinnatichildrens.org/service/p/pathology/specialties/cardiac-pathology

Entomology and Plant Pathology. Department of Entomology and Plant Pathology. NC State University. Campus Box 7613. Raleigh, NC ... Explore Entomology and Plant Pathology Now Hiring: Assistant Professors - Extension Field Crop Plant Pathology ... Our undergraduate and graduate students get the hands-on entomology and plant pathology preparation they need for challenging ... The Department of Entomology and Plant Pathology (DEPP) is dedicated to providing education, research, extension, and ...

https://cals.ncsu.edu/entomology-and-plant-pathology/

Division of High-Consequence Pathogens and Pathology (DHCPP) ...

https://www.cdc.gov/hantavirus/technical/hps/pathology.html

UMFIX/RTP is a "robust platform for molecular-friendly surgical pathology," Mehrdad Nadji, MD, FASCP, professor of pathology ... Pathology laboratories in the 21st century must work to design and execute a biomarker-friendly standardized tissue handling - ... Nadji told Medscape Pathology. "In fact, patients who undergo prostate or breast-needle biopsies could receive their diagnoses ... In certain cases, the pathology diagnosis has to be confirmed by ancillary diagnostic testing. In the end, the patient would ...

https://www.medscape.com/viewarticle/582383

Speech-Language Pathology Services for the Treatment of Dysphagia (170.3). ... Outpatient Speech Language Pathology Services. Please Note: This may not be an exhaustive list of all applicable Medicare ... Speech-Language Pathology Services for the Treatment of Dysphagia. 2. 10/01/2006 - N/A. You are here ... Speech-language pathology services are covered under Medicare for the treatment of dysphagia, regardless of the presence of a ...

https://www.cms.gov/medicare-coverage-database/view/ncd.aspx?NCDId=192&ncdver=2&bc=AAAAEAAAAAAA&

World Health Organization, Expert Committee on Epidemiology of Onchocerciasis & Duke, B.O.L. (‎1975)‎. Pathology and symptoms. ...

https://apps.who.int/iris/handle/10665/365428?locale-attribute=pt&

Tackling Common Orthopedic Pathologies. As with every type of massage, a thorough pre-treatment assessment of the client is key ... Massage + Orthopedic Pathologies Soft tissue rehabilitation is a mainstay of massage therapy in orthopedic settings. ... in orthopedic pathologies. "Postural evaluations are a large part of those assessments, as well as passive and active range-of- ...

https://www.amtamassage.org/publications/massage-therapy-journal/massage-orthopedic-pathologies

... TR-352 N-METHYLOLACRYLAMIDE. Pathology Tables - Rats. *P03 - Incidence Rates of Non- ... Pathology Tables - Mice. *P03 - Incidence Rates of Non-Neoplastic Lesions By Anatomic Site. *P04 - Individual Animal Tumor ... P04 - Individual Animal Tumor Pathology Tables (Neoplasms by Individual Animal). *P05 - Incidence Rates of Neoplasms By ... P09 - Individual Animal Non-Tumor Pathology Tables (Nonneoplastic Lesions by Individual Animal). *P11 - Statistical Analysis of ...

https://ntp.niehs.nih.gov/data/tables/tr/300s/tr352/index.html

Counseling, Higher Education, and Speech-Language Pathology *Counseling, Higher Education, and Speech-Language Pathology Vision ... Counseling, Higher Education, and Speech-Language Pathology Vision and Mission. Vision Statement. The vision of the Department ... Counseling, Higher Education, and Speech-Language Pathology Vision and Mission. *Skip to content ... including outreach through a comprehensive community clinic that delivers speech-language pathology, audiology, developmental ...

https://www.westga.edu/academics/education/cspc/vison-mission.php

encoded search term (Peroneal Tendon Pathology) and Peroneal Tendon Pathology What to Read Next on Medscape ... Peroneal Tendon Pathology Differential Diagnoses. Updated: Nov 04, 2022 * Author: Rajesh Malhotra, MBBS, MS; Chief Editor: ... Pathologies of the Peroneals: A Review. Foot Ankle Spec. 2021 Apr. 14 (2):170-177. [QxMD MEDLINE Link]. ... Comparison of Preoperative MRI With Intraoperative Findings for Peroneal Tendon Pathologies. J Foot Ankle Surg. 2022 Jul-Aug. ...

https://emedicine.medscape.com/article/1236405-differential

Serving more than 600,000 patients each year in the Upper Midwest and beyond at seven hospitals and more than 80 outpatient sites.

https://www.uwhealth.org/locations/american-family-childrens-hospital-169/pediatric-pathology-1265

The In Vivo Pathology Suite ZEISS CONVIVO allows real-time feedback on tissue microstructure during brain surgery through ... automated slide scanners as well as innovative endomicroscope for in situ work ZEISS supports workflows in pathology. ...

https://www.zeiss.com/meditec/en/specialties/pathology.html

https://jcp.bmj.com/login/shibboleth?subcode=bmjjournals&env=prod&uri=https%3A//jcp.bmj.com/content/64/8/701

Official Journal of The Arthur Purdy Stout Society of Surgical Pathologists and The Gastrointestinal Pathology Society. ... The American Journal of Surgical Pathology has achieved worldwide recognition for its outstanding coverage of the state of the ... art in human surgical pathology. In each monthly issue, experts present original articles, review articles, detailed case ... Articles by John S. Cupp, MD : The American Journal of Surgical Pathology. ...

https://journals.lww.com/ajsp/pages/author.aspx?firstName=John&middleName=S.&lastName=Cupp

... News-Medical. 30 November 2022. ,https://www.news-medical.net/health/Endometriosis-Pathology.aspx,. ... Endometriosis Pathology. News-Medical, viewed 30 November 2022, https://www.news-medical.net/health/Endometriosis-Pathology. ... Endometriosis Pathology. News-Medical. https://www.news-medical.net/health/Endometriosis-Pathology.aspx. (accessed November 30 ... 2019, February 26). Endometriosis Pathology. News-Medical. Retrieved on November 30, 2022 from https://www.news-medical.net/ ...

https://www.news-medical.net/health/Endometriosis-Pathology.aspx

Soft tissue - Plexiform fibrohistiocytic tumor

https://www.pathologyoutlines.com/topic/softtissueplexiformfh.html

Other articles where paroxysmal cold hemoglobinuria is discussed: hemolysis:

https://www.britannica.com/science/paroxysmal-cold-hemoglobinuria

Contact Laboratory Medicine & Pathology Department of Laboratory Medicine and Pathology. University of Alberta. 5-411 Edmonton ...

https://www.ualberta.ca/laboratory-medicine-and-pathology/people/emeritus.html

The mission of the National Institute of Environmental Health Sciences is to discover how the environment affects people in order to promote healthier lives.

https://www.niehs.nih.gov/research/atniehs/labs/cmp/mole-path/gallery/index.cfm

The Department of Plant Pathology and Crop Physiology is recognized nationally and internationally for applied and basic ... Plant Pathology Academics. Extension. Top. Faculty, staff and students in the department conduct research and assist Louisiana ... Department of Plant Pathology & Crop Physiology. 302 Life Science Building. Louisiana State University Baton Rouge, LA 70803 ...

https://www.lsu.edu/agriculture/plant/extension/index.php

Zouhair, K., El Ouazzani, T., El Omari, K., El Fajri, S. & Lakhdar, H. (‎2002)‎. [‎Vulvar pathology]‎. EMHJ - Eastern ... The most common infectious pathology was papillomavirus infection, found in 273 cases [‎34.77%]‎, followed by vulvovaginal ... The most common non-infectious pathology was vulvar dermatosis: 259 cases [‎32.99%]‎; idiopathic pruritus vulvae: 61 cases [‎ ...

https://extranet.who.int/iris/restricted/handle/10665/119232?locale-attribute=es&

Quality Indicators for Professional Service Programs in Audiology and Speech-Language Pathology ... hiring and supervising speech-language pathology assistants (SLPA) and/or clinical fellows, and other aspects, including ... audiology and speech-language pathology support personnel; and students. ...

https://www.asha.org/slp/ppresources/

Purchase Oral and Maxillofacial Pathology - 3rd Edition. Print Book & E-Book. ISBN 9781416034353, 9781437721973 ...

https://www.elsevier.com/books/oral-and-maxillofacial-pathology/neville/978-1-4160-3435-3

See how to contact the OHSU Department of Pathology by address, phone or fax. ... Department of Pathology and Laboratory Medicine Department of Pathology and Laboratory Medicine * About Us * What is Pathology? ... Surgical Pathology. 3181 S.W. Sam Jackson Park Road, L-471. Portland, OR 97239. Phone: 503-494-6776. Fax: 503-494-6787 ... Pathology School of Medicine Administrative Office. 3181 S.W. Sam Jackson Park Road, L-113. Portland, OR 97239. Phone: 503-494- ...

https://www.ohsu.edu/school-of-medicine/pathology/contact

The Molecular Plant Pathology Laboratory is located in Beltsville, MD and is part of the Northeast Area.. The Acting Research ... The mission of the Molecular Plant Pathology Laboratory is to solve problems related to the management and control of ...

https://www.ars.usda.gov/northeast-area/beltsville-md-barc/beltsville-agricultural-research-center/molecular-plant-pathology-laboratory/

Sir William Dunn School of Pathology. Research at the Dunn School addresses the fundamental causes of human disease and the ...

https://www.ox.ac.uk/admissions/graduate/courses/medical-sciences/pathology

Close Off-Canvas Mobile Menu ...

https://www.utmb.edu/pathology/education

40 quotes have been tagged as pathology: Alain de Botton: One rarely falls in love without being as much attracted to what is ... Pathology Quotes. Quotes tagged as "pathology" Showing 1-30 of 40 "One rarely falls in love without being as much attracted to ... The whole culture is geared to this kind of pathology and arranged the means to give satisfactions which fit the pathology. The ... Hence, the pathology." ― Craig D. Lounsbrough tags: destroyed, ego, ego-centric, greed, illness, killed, narcissistic, ...

https://www.goodreads.com/quotes/tag/pathology

... provides targeted coverage of the key developments in anatomic and surgical pathology. It covers ... from recent world literature and offers invaluable assistance in managing the increasing flow of information in pathology. ... Advances in Anatomic Pathology. You may be trying to access this site from a secured browser on the server. Please enable ...

https://journals.lww.com/anatomicpathology/pages/login.aspx?ContextUrl=https%3A%2F%2Flww.com%2Fsecure%2Fpages%2Factivatesubscription.aspx%3FContextUrl%3D%2Fanatomicpathology%2FAbstract%2F2010%2F05000%2FThe_Utility_of_Discovered_on_Gastrointestinal.8.aspx

Provide outreach to the community, including outreach through a comprehensive community clinic that delivers speech-language pathology, audiology, developmental reading instruction, special education, counseling, and related diagnostic and educational services. (westga.edu)
The following information assists in understanding the nuances of service delivery, including providing telepractice service, hiring and supervising speech-language pathology assistants (SLPA) and/or clinical fellows, and other aspects, including providing counseling and culturally competent SLP services. (asha.org)
Our clinic offers critical Speech-Language-Pathology services to patients in Kansas City and the surrounding area. (kumc.edu)
Our Speech-Language Pathology Clinic , located at KU Medical Center, offers comprehensive services to people with communicative disorders throughout the Kansas City area. (kumc.edu)
The Speech-Language Pathology Clinic is located at KU Medical Center behind The University of Kansas Hospital in the Miller Building. (kumc.edu)
Speech-language pathology staff members have a master's degree or PhD in speech-language pathology, a certificate of clinical competence (CCC) granted by the American Speech-Language-Hearing Association and a license from the Ohio Board of Speech Pathology and Audiology . (cincinnatichildrens.org)
Speech language pathology is the study of speech and language disorders that can occur in both adults and children. (gradschools.com)
Speech language pathology (SLP) graduate programs are generally concerned with therapy. (gradschools.com)
However, different types of speech language pathology roles may have different professional requirements. (gradschools.com)
For example, a masters program focused on speech language pathology in an educational setting might be somewhat different from one that is more clinically focused. (gradschools.com)
If you're looking for a speech language pathology master program to work toward licensure, make sure you review the specific requirements in your state. (gradschools.com)
Speech Language Pathology Doctorate Programs may offer a wide variety of speech pathology degrees. (gradschools.com)
The Speech-Language Pathology Department evaluates children with speech, language, cognitive, feeding, swallowing and auditory impairments and provides specialized therapies to develop their language skills. (rchsd.org)

The In Vivo Pathology Suite ZEISS CONVIVO allows real-time feedback on tissue microstructure during brain surgery through digital pathology consultation. (zeiss.com)
We therefore established a computational diagnostic algorithm to quantitatively measure spatial densities of tumor-infiltrating CD8+ T cells by digital pathology within the three known tumor compartments as recommended by the International Immuno-Oncology Biomarker Working Group in 116 prospective metastatic melanomas of the Swiss Tumor Profiler cohort. (nature.com)
The digital pathology market in Europe is expected to grow from US$ 243.97 million in 2022 to US$ 474.42 million by 2028. (reportlinker.com)
The setup required for digital pathology can be easily adopted in rural labs and hospitals.Further, telepathology, which is described as a remote telecommunications consultation, primarily, for the diagnosis or treatment, helps close bridge the gap between two or more geographically distant healthcare providers by eliminating geographic and functional barriers. (reportlinker.com)
Thus, the growing acceptance of telepathology is fuelling the digital pathology market growth. (reportlinker.com)
Digital pathology process scans glass slides and produces virtual images.The virtual image is paired with associated clinical information to give pathologists an integrated picture of cancer patients. (reportlinker.com)
Furthermore, according to a study by Association of Clinical Pathologists, digital pathology adoption is high in the UK, and its usage is likely to increase in the coming years. (reportlinker.com)
In addition, pathologists in the UK seek guidance, training, and education on digital pathology solutions. (reportlinker.com)
The Europe Digital Pathology Market is segmented into product , type, application and end user. (reportlinker.com)
are the leading companies operating in the digital pathology in the region. (reportlinker.com)
Innovative Application of Ai-Extracted Digital Pathology Data" from 7:00-8:00pm PT in the MGM Grand & Casino in Chairman's Ballroom - Room 368! (aiforia.com)
UCT Digital Pathology by Department of Pathology, University of Cape Town is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License . (uct.ac.za)

Retrieved on November 30, 2022 from https://www.news-medical.net/health/Endometriosis-Pathology.aspx. (news-medical.net)
Based on type, the market is segmented into human pathology, and veterinary pathology.The human pathology segment held the larger market share in 2022. (reportlinker.com)
La información en esta página debería ser considerada como ejemplos de información de antecedentes para la temporada de influenza 2021-2022 para la práctica médica respecto del uso de medicamentos antivirales contra la influenza. (cdc.gov)

Our undergraduate and graduate students get the hands-on entomology and plant pathology preparation they need for challenging careers in industry, government or academia. (ncsu.edu)
The Department of Entomology and Plant Pathology (DEPP) is dedicated to providing education, research, extension, and professional development for all of its students, staff, faculty, and other stakeholders. (ncsu.edu)
The mission of the Molecular Plant Pathology Laboratory is to solve problems related to the management and control of agriculturally important plant diseases. (usda.gov)
The Molecular Plant Pathology Laboratory is located in Beltsville, MD and is part of the Northeast Area . (usda.gov)
The Hamilton lab is part of the new Arthropod Molecular Systematics lab at the University of Idaho Department of Entomology, Plant Pathology and Nematology. (uidaho.edu)

October 22, 2008 (Baltimore, Maryland) - An innovative technique of tissue processing, developed by the pathologists at the University of Miami, in Florida, makes it possible for patients to have the results of their tissue biopsies in approximately 2 hours, according to findings presented here at the American Society for Clinical Pathology 2008 Annual Meeting. (medscape.com)
American Society for Clinical Pathology (ASCP) 2008 Annual Meeting: Seminar A210. (medscape.com)
3D shape analysis of the supraspinatus muscle: a clinical study of the relationship between shape and pathology. (medscape.com)
For the appropriate student, a project will be developed to better understand the central defects that may underpin the neuroendocrine pathology of PCOS in a pre-clinical model of the syndrome. (otago.ac.nz)
The Department of Pathology is a community of basic and clinical scientists, educators and staff dedicated to advancing the research and teaching mission of Harvard Medical School. (harvard.edu)
Can a Department of Pathology and Laboratory Medicine be both state-of-the-art and push the envelope in its mission to educate, research, and provide clinical and anatomic pathology services? (rochester.edu)
Basic Science , Anatomic Pathology and Clinical Pathology . (umassmed.edu)
This effort is centered in the Divisions of Anatomic Pathology and Clinical Pathology and has been highly successful in the development of new tests and biomarkers and translating them into clinical practice. (umassmed.edu)
11 March 2018 - Dr John Jabbour, WHO Representative for Egypt, and Dr Omar Abou El Ata, Technical Officer for Antimicrobial Resistance, attended the tenth annual clinical pathology conference, which took place in Hurghada from 21 to 24 F ebruary 2018. (who.int)
We provide leading-edge anatomic and clinical pathology services to hospitals, ambulatory surgery centers, and physician practices. (clinpathassoc.com)
The dentist must know the histological, clinical and radiographic features of these pathologies to recognize them and indicate the best treatment option. (bvsalud.org)

UMFIX/RTP is a "robust platform for molecular-friendly surgical pathology," Mehrdad Nadji, MD, FASCP, professor of pathology and director of the immunohistochemistry laboratory at the University of Miami School of Medicine, told the meeting attendees. (medscape.com)
Cite this: Molecular-Friendly Surgical Pathology Fights Tradition and Preserves Patients' DNA - Medscape - Oct 22, 2008. (medscape.com)
The American Journal of Surgical Pathology. (lww.com)
Thought you might appreciate this item(s) I saw in The American Journal of Surgical Pathology. (lww.com)
same download progress in surgical pathology volume with high browser, and has a back being knowledge surgeons. (stovu.net)
Since this emphasizes a only conformational download progress in surgical pathology it inspires learning person and sweet glyphs. (stovu.net)
Please enter your email address to continue to the Johns Hopkins Surgical Pathology Case Conference website. (jhu.edu)
An important cornerstone in health care delivery is the field of surgical pathology and one of its major aims is to provide a complete, precise and comprehensive diagnosis within a short period of time . (bvsalud.org)
In achieving this, the clinician needs to properly fill a surgical pathology requisition form. (bvsalud.org)

Specific areas of expertise include lymphoma pathology, neuropathology and gynaecological pathology, renal pathology, hepato-biliary pathology and gastro-intestinal pathology. (imperial.ac.uk)

Turkish Journal of Pathology (http://www.turkjpath.org)(ISSN:1018- 5615 / E-ISSN:1309-5730) is the official journal of the Federation of Turkish Pathology Societies and is devoted to the continuing education of national and international practicing pathologists, and to provide a forum for social and scientific communication in the field. (turkjpath.org)

This is a case study presented by the University of Pittsburgh Department of Pathology in which a 18-year-old male with "painless enlargement of the right testes over a period of several months, initially attributed to a sports injury. (merlot.org)
Join our team at The UT Southwestern Department of Pathology and become a part of a world-renowned group of physicians, researchers, and professional staff. (utsouthwestern.edu)
The faculty and staff in the UT Southwestern Department of Pathology work with a wide variety of professional staff across our multiple affiliated facilities. (utsouthwestern.edu)
The Department of Pathology and Laboratory Medicine is committed to providing services of the highest quality. (rochester.edu)
I have had the privilege of heading the Department of Pathology at UMass since 1997. (umassmed.edu)
We'd like to send you periodic updates regarding Pathology educational materials released by our department. (jhu.edu)

In certain cases, the pathology diagnosis has to be confirmed by ancillary diagnostic testing. (medscape.com)
SOX10 (SRY-related HMG-box 10 protein), a transcription factor expressed in melanocytic and Schwann cell lineages, is being increasingly used in breast pathology as an aid in the diagnosis of metastatic TNBC and, to a lesser degree, as a myoepithelial cell marker. (medscape.com)
In summary, Rammal et al [ 2 ] confirm the usefulness of SOX10 in the practice of breast pathology, mainly its utility as a marker for TNBC, its role in cases in which gynecologic malignancies are in the differential, and its value in the diagnosis of atypia. (medscape.com)
Diagnosis and appropriate correction of intrauterine anomalies are considered et d'Application en Chirurgie essential in order to increase chances of conception. (who.int)

You are welcome to join our new group, 'Pathology & Laboratory Medicine Alumni and Friends. (rochester.edu)

To access the article in PDF format , you should be a subscriber to Indian Journal of Pathology and Microbiology. (ijpmonline.org)

Research from over 100 laboratories that comprise the HMS Pathology community is vastly interdisciplinary, drawing from all aspects of physiology and pathophysiology of human disease, including neuroscience, cardiovascular disease, cancer, immunology, digestive disease, reproductive biology, stem cells and regenerative medicine, and metabolism. (harvard.edu)
Pathology faculty are affiliated with the major PhD programs located at HMS including BBS, BIG, Biophysics, Neuroscience and Immunology. (harvard.edu)
Learn more about our Immunology, Pathology & Infectious Disease (IPID) Graduate Program . (unmc.edu)

Cell Pathology was a new title re-launched in 2020 in place of Endoplasmic Reticulum Stress in Diseases journal. (degruyter.com)

Pathology laboratories in the 21st century must work to design and execute a biomarker-friendly standardized tissue handling - including fixation and processing - to ensure uniform protection of macromolecules for immunohistochemical and molecular assays. (medscape.com)
He has also developed new approaches to analysing tissue using computational pathology, metabonomic and other imaging techniques. (imperial.ac.uk)
Once the diseased tissue is removed, the specimen is sent to pathology to specifically diagnose the tissue as endometriosis and to rule out endometrial cancer. (womensexcellence.com)

Browse Services and find information for patients of NSW Health Pathology. (nsw.gov.au)
February 14, 2012 - Poor-quality sleep is associated with increased amyloid pathology in patients who are cognitively normal, early results of a new study suggest. (medscape.com)
Abnormal uterine findings were de Recherche et d'Application en identified in 95.8% of patients attending hysteroscopy at GESHRTH. (who.int)

The forensic pathology industry is facing a workforce shortage. (newschannel5.com)
He's an expert in the forensic pathology industry. (newschannel5.com)
And I think this is an opportunity for forensic pathology to be on the forefront and let the public at large know what we do, how we do it, and to encourage young people to pursue a career in forensic pathology," Diaz said. (newschannel5.com)
We're proud to be Australia's largest public pathology and forensic & analytical science service, employing more than 5,000 staff. (nsw.gov.au)

Additional departmental investigators are located in the Experimental Pathology Unit (Drs. Frederic Preffer and James Stone), the Immunopathology Research (Drs. Robert Colvin and Rex Neal Smith), the Center for Integrated Diagnostics (Drs. Long Phi Le, Jochen Lennerz and Dora Dias-Santagata, PhD) and Pathology Informatics and Imaging Research Unit (Drs. Anand Dighe, Markus Herrmann, and Jochen Lennerz). (massgeneral.org)
In addition, most Pathology Service staff are involved in diverse clinicopathological research activities. (massgeneral.org)
Pathology Research activities occupy approximately 20,000 square feet within Pathology, with Pathology researchers receiving over $19 million in direct costs of annual research support. (massgeneral.org)
The Division of Research works with all Units of the Pathology Service to foster its research mission. (massgeneral.org)
Activities include a popular, weekly pan-departmental Molecular Pathology and Research (MPR) conference, development of a molecular pathology rotation for Pathology residents, a pathology research mentoring program for residents, and an NIH Training Grant that supports seven fellows per year. (massgeneral.org)
Our journal sought high-quality original research reports, reviews, and commentaries related to all aspects of cell pathology. (degruyter.com)
Generally, PhD in speech pathology programs are research-oriented or academic. (gradschools.com)
Efforts by the breast pathology community and years of research have led to the establishment of precise diagnostic criteria and classification of most lesions. (medscape.com)
Members of the Section of Pathology lead their own research groups and also work closely with other groups at Imperial and beyond. (imperial.ac.uk)
Dr. Beamer is currently Director of Research Pathology at Aiforia, Inc., Cambridge, MA and Adjunct Associate Professor at Texas Biomedical Research Institute, San Antonio, Texas. (aiforia.com)
Every day, our NSW Health Pathology colleagues take part in innovative research to improve public health and safety. (nsw.gov.au)
Dr. Unger's research took her into the new field of molecular pathology, which uses unique characteristics of genes to identify cancers. (cdc.gov)

Participants with frequent awakenings, defined as more than 5 per hour, were more likely to have these abnormal biomarkers of amyloid pathology. (medscape.com)

2018 Palo Alto Pathology, Inc. (paloaltopath.com)

One of the many facets of our surgeons' specialist training is the knowledge and management of the majority of lesions and pathologies affecting the orofacial sphere. (cliniquemaxillo.com)

With a broad range of solutions spanning classic microscopes, automated slide scanners as well as innovative endomicroscope for in situ work ZEISS supports workflows in pathology. (zeiss.com)

A Curriculum for Genomic Education of Molecular Genetic Pathology Fellows: A Report of the Association for Molecular Pathology Training and Education Committee. (cornell.edu)

2019. Endometriosis Pathology . (news-medical.net)

This inaugural issue of Advances in Molecular Pathology will provide a comprehensive review of the most current practices, trends, and developments in the field of Molecular Pathology. (elsevierhealth.com)

Diagnostic Pathology 2015, 1:97. (diagnosticpathology.eu)
Le diagnostic et la prise en charge adéquate des lésions intra cavitaires permettent d'am liorer les chances de conception. (who.int)

In addition, physicians in the specialties of anesthesiology, pathology, and radiology were excluded from the physician universe. (cdc.gov)
Not in specialties of anesthesiology, pathology, and radiology. (cdc.gov)

[ 1 ] The use of immunohistochemistry (IHC) is an essential addition to the daily practice of breast pathology. (medscape.com)

What is a Speech Pathology Graduate Programs? (gradschools.com)
Speech pathology graduate programs are available at the master's, doctorate and certificate levels. (gradschools.com)
Graduate speech pathology programs may be more theoretical in nature and focus on developing expertise regarding systems and conditions. (gradschools.com)
Graduate Certificates in Speech and Language Pathology programs often have fewer required courses than degrees. (gradschools.com)
Earning a graduate certificate in speech pathology could be one way for somebody in the field to expand expertise in a new area. (gradschools.com)
Speech pathology graduate programs could be available in a variety of formats. (gradschools.com)

Cell Pathology was an open-access, peer-reviewed journal that focused on the abnormal state of cells driven by cell-intrinsic or extrinsic influences that manifest in changes of the morphology, loss of homeostasis, and/or alternations in the genetic profiles of cells. (degruyter.com)
Turkish Journal of Pathology accepts only invited review articles. (turkjpath.org)

Anatomy37

Organisms10

Diseases74

Chemicals and Drugs25

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Psychiatry and Psychology16

Phenomena and Processes23

Disciplines and Occupations15

Anthropology, Education, Sociology and Social Phenomena2

Humanities2

Information Science11

Named Groups1

Health Care26

An assessment of the operation of an external quality assessment (EQA) scheme in histopathology in the South Thames (West) region: 1995-1998. (1/578)

The efficacy and limitations of repeated slide conferences for improving interobserver agreement when judging nuclear atypia of breast cancer. The Japan National Surgical Adjuvant Study of Breast Cancer (NSAS-BC) Pathology Section. (2/578)

Attracting and training more chemical pathologists in the United Kingdom. (3/578)

The pathologist and toxicologist in pharmaceutical product discovery. (4/578)

Mechanisms of disease and injury: utilization of mutants, monoclonals, and molecular methods. (5/578)

Computer-based teaching of pathology at the Zagreb University School of Medicine. (6/578)

A century of pathology at Yale: personal reflections. (7/578)

An evaluation of the Banff classification of early renal allograft biopsies and correlation with outcome. (8/578)

Pathology

Pathology, Clinical

Pathology, Surgical

Pathology Department, Hospital

Pathology, Oral

Alzheimer Disease

Disease Models, Animal

Pathology, Molecular

Pathology, Veterinary

Telepathology

tau Proteins

Neurofibrillary Tangles

Brain

Speech-Language Pathology

Mice, Transgenic

Amyloid beta-Peptides

Plaque, Amyloid

Mice, Inbred C57BL

Forensic Pathology

Autopsy

Tauopathies

Immunohistochemistry

Magnetic Resonance Imaging

Retrospective Studies

Mice, Knockout

Lewy Bodies

Amyloid beta-Protein Precursor

Biopsy

Aging

Nerve Degeneration

Time Factors

Lung

Toxicology

alpha-Synuclein

Neurons

Inflammation

Mutation

Disease Progression

Atrophy

Lewy Body Disease

Neurodegenerative Diseases

Tomography, X-Ray Computed

Frontotemporal Lobar Degeneration

Inclusion Bodies

Phenotype

Pick Disease of the Brain

Treatment Outcome

Signal Transduction

Hippocampus

Sensitivity and Specificity

Cerebral Amyloid Angiopathy

Brain Diseases

Liver

Reproducibility of Results

Gene Expression Regulation

Cells, Cultured

Cytokines

Gliosis

Dementia

Microglia

Biological Markers

Fallopian Tube Diseases

Sclerosis

Image Processing, Computer-Assisted

Parkinson Disease

Mice, Inbred BALB C

Cognition Disorders

Kidney

Cerebral Cortex

Presenilin-1

Tendinopathy

Microscopy

Age Factors

Laboratories, Hospital

Histological Techniques

RNA, Messenger

Mice, Inbred mdx

Diagnostic Errors

Severity of Illness Index

Analysis of Variance