Skin tests in which the sensitizer is applied to a patch of cotton cloth or gauze held in place for approximately 48-72 hours. It is used for the elicitation of a contact hypersensitivity reaction.
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.
A recurrent contact dermatitis caused by substances found in the work place.
A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell, especially a fluid containing fragrant natural oils extracted from flowers, woods, etc., or similar synthetic oils. (Random House Unabridged Dictionary, 2d ed)
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
A non-allergic contact dermatitis caused by prolonged exposure to irritants and not explained by delayed hypersensitivity mechanisms.
Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.
Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Microscopic particles comprising dead skin, dried salivary proteins, hair, SEBUM and microorganisms, shed by animals which causes allergic reactions in atopic persons.
Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.
Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.
A mitosporic fungal genus that causes a variety of skin disorders. Malassezia furfur (Pityrosporum orbiculare) causes TINEA VERSICOLOR.
A transient reddening of the face that may be due to fever, certain drugs, exertion, stress, or a disease process.
Hand dermatoses is a general term referring to various inflammatory skin conditions primarily affecting the hands, such as eczema, psoriasis, and contact dermatitis, characterized by erythema, scaling, vesiculation, fissuring, or lichenification.
A contagious cutaneous inflammation caused by the bite of the mite SARCOPTES SCABIEI. It is characterized by pruritic papular eruptions and burrows and affects primarily the axillae, elbows, wrists, and genitalia, although it can spread to cover the entire body.
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Tests or bioassays that measure the skin sensitization potential of various chemicals.
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.
Superficial infections of the skin or its appendages by any of various fungi.
A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
A skin and mucous membrane disease characterized by an eruption of macules, papules, nodules, vesicles, and/or bullae with characteristic "bull's-eye" lesions usually occurring on the dorsal aspect of the hands and forearms.
A subclass of anhydrides with the general structure of dihydrofurandione. They can be substituted on any carbon atom. They modify and inhibit proteins and enzymes and are used in the acylation of amino- and hydroxyl groups.
Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.
Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
A pruritic papulovesicular dermatitis occurring as a reaction to many endogenous and exogenous agents (Dorland, 27th ed).
Family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.
Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of causes.
Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.
A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Antigens from the house dust mites (DERMATOPHAGOIDES), mainly D. farinae and D. pteronyssinus. They are proteins, found in mite feces or mite extracts, that can cause ASTHMA and other allergic diseases such as perennial rhinitis (RHINITIS, ALLERGIC, PERENNIAL) and atopic dermatitis (DERMATITIS, ATOPIC). More than 11 groups of Dermatophagoides ALLERGENS have been defined. Group I allergens, such as Der f I and Der p I from the above two species, are among the strongest mite immunogens in humans.

Contact dermatitis in Alstroemeria workers. (1/215)

Hand dermatitis is common in workers in the horticultural industry. This study determined the prevalence of hand dermatitis in workers of Alstroemeria cultivation, investigated how many workers had been sensitized by tulipalin A (the allergen in Alstroemeria) and took stock of a wide range of determinants of hand dermatitis. The 12-month period prevalence of major hand dermatitis amounted to 29.5% whereas 7.4% had minor dermatitis. Of these workers, 52.1% were sensitized for tulipalin A. Several personal and work-related determinants played a role in the multifactorial aetiology of hand dermatitis. Factors which showed a significant relationship with major hand dermatitis were: female sex, atopic dermatitis, chapped hands and the frequency of washing hands. It may be concluded that the Alstroemeria workers are a population at risk of developing contact dermatitis and it might be useful to carry out an educational campaign to lower the high prevalence.  (+info)

Sputum eosinophils and exhaled nitric oxide during late asthmatic reaction in patients with western red cedar asthma. (2/215)

Examination of sputum for eosinophils and measurement of exhaled nitric oxide have been proposed as noninvasive methods of assessing airway inflammation in asthma. The use of these tests in the evaluation of patients with occupational asthma has not been reported. This study investigated the changes in sputum eosinophils and exhaled NO before and at intervals after inhalation challenge with plicatic acid in patients with suspected western red cedar asthma. Of 17 subjects who underwent challenge, nine had a positive bronchoconstrictor reaction (responders) and eight had a negative reaction (nonresponders). At 6 and 24 h after plicatic acid challenge, there was a significant increase in sputum eosinophils among responders, which was inversely related to the fall in forced expiratory volume in one second (FEV1) at 6 h. An increase in sputum eosinophils was also found in three nonresponders. Levels of exhaled NO increased at 24 h after challenge with plicatic acid in both responders and nonresponders, being significant only in nonresponders. No correlation was found between the increase in nitric oxide and the magnitude of the functional changes in the airways. There were significant correlations between the degree of sputum eosinophilia and the level of exhaled NO before and after methacholine and plicatic acid challenge. In conclusion, the late asthmatic reaction induced by plicatic acid in patients with western red cedar asthma is associated with an increase in sputum eosinophils. The usefulness of measuring sputum eosinophils and exhaled nitric oxide in the clinical evaluation of patients with suspected occupational asthma caused by low molecular weight compounds has yet to be determined.  (+info)

Sensitivity and exposure to indoor allergens in adults with differing asthma severity. (3/215)

In asthma, it is uncertain whether there is an association between degrees of exposure to domestic allergens and asthma severity. The pattern of sensitivity and exposure to common indoor allergens was examined in subjects with differing asthma severity. Sensitivity to house dust mite, dog and cat allergen and exposure to Der p 1, Can f 1 and Fel d 1 were assessed by skin prick tests and settled dust analysis in 28 subjects with severe asthma and 28 age- and sex-matched subjects with mild asthma (two declined skin prick test). All severe asthmatic subjects had at least one positive skin test and 20 of the 28 subjects were positive to all three allergens. Fourteen of the 26 subjects with mild asthma who took skin prick tests were positive to at least one, and one of these subjects was positive to the three allergens tested. Except for bedroom Fel d 1, the proportion of severe asthmatics both sensitized and exposed to each allergen at each site was significantly greater than the proportion sensitized and exposed in the mild asthma group. The geometric mean allergen concentrations, with the exception of bedroom Fel d 1, were greater in sensitized severe asthmatics than the sensitized mild asthmatics, which was significant for Der p 1 in bedroom samples and Can f 1 in bedroom and living room samples. These results support an association between the degrees of domestic allergen exposure in sensitized individuals and asthma severity.  (+info)

A quantitative comparison of induction and challenge concentrations inducing a 50% positive response in three skin sensitization tests; the guinea pig maximization test, adjuvant and patch test and Buehler test. (4/215)

The sensitivities of three skin sensitization tests such as the Guinea pig maximization test (GPMT), Adjuvant and patch test (APT) and Buehler test (BT), were quantitatively compared with reference to induction and challenge concentrations. Four chemical which had different physico-chemical properties (octanol-water partition coefficient (logP) and reactivity with NH2-group) were used in order to clarify the effect of the physico-chemical properties of chemicals on the sensitivity of the different methods. The induction concentrations inducing a 50% positive response (IC50) demonstrated extreme variation with the three methods. For example, the BT/GPMT ratio of IC50 values for 2,4-dinitrochlorobenzene was 33, whereas that for maleic anhydride was 300,000. The results were thought to be caused by difference properties such as the logP and reactivity of chemicals. This correlation was confirmed by using 2-dodecen-1-yl succinic anhydride, which had the same reactivity but higher logP than that of maleic anhydride. On the other hand, the challenge concentrations inducing 50% positive responses (CC50) were less affected by the methods and the BT/GPMT ratios for CC50 values were all within a 10-fold range. These results suggest that the sensitivity might be strongly different with reference to induction concentration, but not challenge concentration among the three methods.  (+info)

Nickel-induced proliferation of both memory and naive T cells in patch test-negative individuals. (5/215)

Lymphocyte transformation test has often been used as an in vitro test for nickel allergy. We have previously demonstrated the presence of nickel-reactive T cells in individuals with no history of allergic disease and with a negative patch test towards NiSO4. In this study, we show that this proliferative response was mainly confined to T cells within the CD4+ subset. In contrast to conventional recall antigens such as tetanus toxoid, in vitro stimulation using NiSO4 activated both FACS-purified CD4+CD45RA+ 'naive' and CD4+CD45RO+ 'memory' T cells. To determine which cell population reacted with nickel to induce T cell activation, peripheral blood mononuclear cells were separated into macrophages and non-adherent, HLA-DR-depleted T cells. We found that preincubation of monocytes/macrophages but not T cells with NiSO4 resulted in subsequent T cell proliferation. This result demonstrated that nickel did not exhibit any direct effect on the T cell. Furthermore, the NiSO4-induced T cell proliferation could be blocked by antibodies towards MHC class II (HLA-DR) molecules. Our results substantiate the concept that individuals with a negative patch test towards NiSO4 contain in their peripheral blood T cells capable of recognizing nickel or nickel-modified peptides. In contrast to conventional recall antigens, both memory and naive T cells were activated. Thus, when compared with data obtained from nickel-allergic individuals, this study shows a comparable nickel-inducible T cell activation in non-allergic individuals.  (+info)

Occupational induction of hypersensitivity after an accidental exposure to chloromethylisothiazolinone and methylisothiazolinone (CMI/MI) in an industrial worker. (6/215)

A process worker in a paper chemical plant developed an immediate local dermal irritation and delayed bullous dermatitis due to induction of hypersensitivity following an accidental exposure to chloromethylisothiazolinone and methylisothiazolinone (CMI/MI) biocide. Contact allergy to the isothiazolinone mixture was confirmed by skin patch testing. The dermatitis healed in four weeks, and the worker was advised to avoid all CMI/MI containing products. In a one-year follow-up he did not present with any further skin symptoms. Preventive measures are important for avoiding induction of hypersensitivity to concentrated CMI/MI solutions in industrial workers.  (+info)

Analysis of aldehyde dehydrogenase 2 gene polymorphism and ethanol patch test as a screening method for alcohol sensitivity. (7/215)

To assess clinical availability of the aldehyde dehydrogenase (ALDH) 2 gene polymorphism to detect alcohol sensitivity among a Japanese population, we determined the ALDH 2 genotypes and also compared to an ethanol patch test in 119 young Japanese. Their alcohol sensitivity was evaluated by a questionnaire on the frequency of alcohol-associated symptoms when they drink. Genomic DNA was extracted from blood samples and amplified by polymerase chain reaction (PCR). PCR primers were flanking the polymorphic region in exon 12 of the ALDH 2 gene. The distribution of the typical homozygote, the heterozygote and the atypical homozygote was 63.9, 31.9 and 4.2%, respectively. Gene frequencies of the typical and atypical alleles calculated from the genotype frequencies were 0.80 and 0.20. The atypical genotypic homozygotes were positively associated with facial flushing symptom, but not with positive response for ethanol patch test. These results indicate that ALDH 2 genotypes determination is essential to detect alcohol sensitivity whereas the ethanol patch test has some limitations.  (+info)

The CXCR3 activating chemokines IP-10, Mig, and IP-9 are expressed in allergic but not in irritant patch test reactions. (8/215)

Differentiation between allergic and irritant contact dermatitis reactions is difficult, as both inflammatory diseases are clinically, histologically, and immunohistologically very similar. Previous studies in mice revealed that the chemokine IP-10 is exclusively expressed in allergic contact dermatitis reactions. In the present study, we investigated whether the mRNA expression of IP-10 and the related CXCR3 activating chemokines, Mig and IP-9 are also differentially expressed in human allergic contact dermatitis and irritant contact dermatitis reactions. Skin biopsies from allergic (13 cases) and sodium lauryl sulfate-induced irritant patch test reactions (13 cases), obtained 1-72 h after patch testing, were studied by means of an in situ hybridization technique. Results of chemokine mRNA expression were correlated with clinical scoring, histology, and immunohistochemical data including the proportion of inflammatory cells expressing CXCR3, the receptor for IP-10, Mig, and IP-9, and ICAM-1 and HLA-DR expression on keratinocytes. IP-10, Mig, and IP-9 mRNA were detected in seven of nine allergic contact dermatitis reactions after 24-72 h, but not in sodium lauryl sulfate-induced irritant contact dermatitis reactions. ICAM-1 expression by keratinocytes was only found in allergic contact dermatitis reactions and correlated with chemokine expression. Moreover, up to 50% of the infiltrating cells in allergic contact dermatitis expressed CXCR3, in contrast to only 20% in irritant contact dermatitis reactions. In conclusion, we have demonstrated differences in chemokine expression between allergic contact dermatitis and irritant contact dermatitis reactions, which might reflect different regulatory mechanisms operating in these diseases and may be an important clue for differentiation between allergic contact dermatitis and irritant contact dermatitis reactions.  (+info)

A patch test is a method used in clinical dermatology to identify whether a specific substance causes allergic inflammation of the skin (contact dermatitis). It involves applying small amounts of potential allergens to patches, which are then placed on the skin and left for a set period of time, usually 48 hours. The skin is then examined for signs of an allergic reaction such as redness, swelling or blistering. This helps in identifying the specific substances that an individual may be allergic to, enabling appropriate avoidance measures and treatment.

Allergic contact dermatitis is a type of inflammatory skin reaction that occurs when the skin comes into contact with a substance (allergen) that the immune system recognizes as foreign and triggers an allergic response. This condition is characterized by redness, itching, swelling, blistering, and cracking of the skin, which usually develops within 24-48 hours after exposure to the allergen. Common allergens include metals (such as nickel), rubber, medications, fragrances, and cosmetics. It is important to note that a person must first be sensitized to the allergen before developing an allergic response upon subsequent exposures.

Occupational dermatitis is a specific type of contact dermatitis that results from exposure to certain substances or conditions in the workplace. It can be caused by direct contact with chemicals, irritants, or allergens present in the work environment. This condition typically affects the skin on the hands and forearms but can also involve other areas of the body, depending on the nature of the exposure.

There are two main types of occupational dermatitis:

1. Irritant contact dermatitis (ICD): This type occurs when the skin comes into direct contact with an irritating substance, leading to redness, swelling, itching, and sometimes blistering. Common irritants include solvents, detergents, oils, and other industrial chemicals.
2. Allergic contact dermatitis (ACD): This type is a result of an allergic reaction to a specific substance. The immune system identifies the allergen as harmful and mounts a response, causing skin inflammation. Common allergens include latex, metals (such as nickel), and certain plants (like poison ivy).

Prevention measures for occupational dermatitis include using appropriate personal protective equipment (PPE) like gloves, masks, and aprons, as well as practicing good hygiene, such as washing hands regularly and avoiding touching the face with contaminated hands. If you suspect you have developed occupational dermatitis, consult a healthcare professional for proper diagnosis and treatment.

I'm sorry for any confusion, but "perfume" is not a term that has a medical definition. Perfumes are fragranced products used primarily for personal grooming and aesthetic purposes. They consist of a mixture of essential oils or aroma compounds, fixatives, and solvents.

Perfumes can sometimes cause allergic reactions or irritations in some individuals, leading to symptoms such as skin rashes, itching, or sneezing. In such cases, people might consult with healthcare professionals for advice on avoiding specific fragrances or managing related allergies. However, the term "perfume" itself is not a medical concept and does not have a medical definition.

Atopic dermatitis is a chronic, inflammatory skin condition that is commonly known as eczema. It is characterized by dry, itchy, and scaly patches on the skin that can become red, swollen, and cracked over time. The condition often affects the skin on the face, hands, feet, and behind the knees, and it can be triggered or worsened by exposure to certain allergens, irritants, stress, or changes in temperature and humidity. Atopic dermatitis is more common in people with a family history of allergies, such as asthma or hay fever, and it often begins in infancy or early childhood. The exact cause of atopic dermatitis is not fully understood, but it is thought to involve a combination of genetic and environmental factors that affect the immune system and the skin's ability to maintain a healthy barrier function.

Irritant contact dermatitis is a type of inflammation of the skin (dermatitis) that results from exposure to an external substance that directly damages the skin. It can be caused by both chemical and physical agents, such as solvents, detergents, acids, alkalis, friction, and extreme temperatures. The reaction typically occurs within hours or days of exposure and can cause symptoms such as redness, swelling, itching, burning, and pain. Unlike allergic contact dermatitis, which requires sensitization to a specific allergen, irritant contact dermatitis can occur after a single exposure to an irritant in sufficient concentration or after repeated exposures to lower concentrations of the substance.

Skin tests are medical diagnostic procedures that involve the application of a small amount of a substance to the skin, usually through a scratch, prick, or injection, to determine if the body has an allergic reaction to it. The most common type of skin test is the patch test, which involves applying a patch containing a small amount of the suspected allergen to the skin and observing the area for signs of a reaction, such as redness, swelling, or itching, over a period of several days. Another type of skin test is the intradermal test, in which a small amount of the substance is injected just beneath the surface of the skin. Skin tests are used to help diagnose allergies, including those to pollen, mold, pets, and foods, as well as to identify sensitivities to medications, chemicals, and other substances.

An allergen is a substance that can cause an allergic reaction in some people. These substances are typically harmless to most people, but for those with allergies, the immune system mistakenly identifies them as threats and overreacts, leading to the release of histamines and other chemicals that cause symptoms such as itching, sneezing, runny nose, rashes, hives, and difficulty breathing. Common allergens include pollen, dust mites, mold spores, pet dander, insect venom, and certain foods or medications. When a person comes into contact with an allergen, they may experience symptoms that range from mild to severe, depending on the individual's sensitivity to the substance and the amount of exposure.

'Dander' is a term used in medicine and biology to refer to tiny particles or flakes that are shed from the skin of humans and animals, particularly those with fur or feathers. In humans, dander consists of dead skin cells, while in animals it can include microscopic bits of hair, feathers, or scales.

Dander is a common allergen for many people, and exposure to it can trigger symptoms such as sneezing, runny nose, itchy eyes, and difficulty breathing. This is especially true for individuals with allergies or asthma. Animal dander can be found in homes, schools, offices, and other public places, and it can be challenging to completely eliminate from the environment. Regular cleaning, vacuuming, and air filtration can help reduce dander levels and alleviate allergy symptoms.

Food hypersensitivity is an umbrella term that encompasses both immunologic and non-immunologic adverse reactions to food. It is also known as "food allergy" or "food intolerance." Food hypersensitivity occurs when the body's immune system or digestive system reacts negatively to a particular food or food component.

Immunologic food hypersensitivity, commonly referred to as a food allergy, involves an immune response mediated by immunoglobulin E (IgE) antibodies. Upon ingestion of the offending food, IgE antibodies bind to the food antigens and trigger the release of histamine and other chemical mediators from mast cells and basophils, leading to symptoms such as hives, swelling, itching, difficulty breathing, or anaphylaxis.

Non-immunologic food hypersensitivity, on the other hand, does not involve the immune system. Instead, it is caused by various mechanisms, including enzyme deficiencies, pharmacological reactions, and metabolic disorders. Examples of non-immunologic food hypersensitivities include lactose intolerance, gluten sensitivity, and histamine intolerance.

It's important to note that the term "food hypersensitivity" is often used interchangeably with "food allergy," but it has a broader definition that includes both immunologic and non-immunologic reactions.

Drug hypersensitivity is an abnormal immune response to a medication or its metabolites. It is a type of adverse drug reaction that occurs in susceptible individuals, characterized by the activation of the immune system leading to inflammation and tissue damage. This reaction can range from mild symptoms such as skin rashes, hives, and itching to more severe reactions like anaphylaxis, which can be life-threatening.

Drug hypersensitivity reactions can be classified into two main types: immediate (or IgE-mediated) and delayed (or non-IgE-mediated). Immediate reactions occur within minutes to a few hours after taking the medication and are mediated by the release of histamine and other inflammatory mediators from mast cells and basophils. Delayed reactions, on the other hand, can take several days to develop and are caused by T-cell activation and subsequent cytokine release.

Common drugs that can cause hypersensitivity reactions include antibiotics (such as penicillins and sulfonamides), nonsteroidal anti-inflammatory drugs (NSAIDs), monoclonal antibodies, and chemotherapeutic agents. It is important to note that previous exposure to a medication does not always guarantee the development of hypersensitivity reactions, as they can also occur after the first administration in some cases.

The diagnosis of drug hypersensitivity involves a thorough medical history, physical examination, and sometimes skin or laboratory tests. Treatment typically includes avoiding the offending medication and managing symptoms with antihistamines, corticosteroids, or other medications as needed. In severe cases, emergency medical care may be required to treat anaphylaxis or other life-threatening reactions.

I'm sorry for any confusion, but "Nickel" is not a medical term. It is a chemical element with the symbol Ni and atomic number 28. Nickel is a hard, silvery-white lustrous metal with a slight golden tinge. It is one of four elements that are ferromagnetic and is used as a common component in various alloys due to its properties such as resistance to corrosion and heat.

However, in a medical context, nickel may refer to:

* Nickel allergy: A type of allergic contact dermatitis caused by an immune system response to the presence of nickel in jewelry, clothing fasteners, or other items that come into contact with the skin. Symptoms can include redness, itching, and rash at the site of exposure.
* Nickel carbonyl: A highly toxic chemical compound (Ni(CO)4) that can cause respiratory and neurological problems if inhaled. It is produced during some industrial processes involving nickel and carbon monoxide and poses a health risk to workers if proper safety measures are not taken.

If you have any concerns about exposure to nickel or symptoms related to nickel allergy, it's best to consult with a healthcare professional for further evaluation and treatment.

Irritants, in a medical context, refer to substances or factors that cause irritation or inflammation when they come into contact with bodily tissues. These substances can cause a range of reactions depending on the type and duration of exposure, as well as individual sensitivity. Common examples include chemicals found in household products, pollutants, allergens, and environmental factors like extreme temperatures or friction.

When irritants come into contact with the skin, eyes, respiratory system, or mucous membranes, they can cause symptoms such as redness, swelling, itching, pain, coughing, sneezing, or difficulty breathing. In some cases, prolonged exposure to irritants can lead to more serious health problems, including chronic inflammation, tissue damage, and disease.

It's important to note that irritants are different from allergens, which trigger an immune response in sensitive individuals. While both can cause similar symptoms, the underlying mechanisms are different: allergens cause a specific immune reaction, while irritants directly affect the affected tissues without involving the immune system.

Malassezia is a genus of fungi (specifically, yeasts) that are commonly found on the skin surfaces of humans and other animals. They are part of the normal flora of the skin, but under certain conditions, they can cause various skin disorders such as dandruff, seborrheic dermatitis, pityriasis versicolor, and atopic dermatitis.

Malassezia species require lipids for growth, and they are able to break down the lipids present in human sebum into fatty acids, which can cause irritation and inflammation of the skin. Malassezia is also associated with fungal infections in people with weakened immune systems.

The genus Malassezia includes several species, such as M. furfur, M. globosa, M. restricta, M. sympodialis, and others. These species can be identified using various laboratory methods, including microscopy, culture, and molecular techniques.

"Flushing" is a medical term that refers to a sudden, temporary reddening of the skin, often accompanied by feelings of warmth. This occurs when the blood vessels beneath the skin dilate or expand, allowing more blood to flow through them. Flushing can be caused by various factors such as emotional stress, alcohol consumption, spicy foods, certain medications, or medical conditions like carcinoid syndrome or menopause. It is generally harmless but can sometimes indicate an underlying issue that requires medical attention.

Hand dermatoses is a general term used to describe various inflammatory skin conditions that affect the hands. These conditions can cause symptoms such as redness, swelling, itching, blistering, scaling, and cracking of the skin on the hands. Common examples of hand dermatoses include:

1. Irritant contact dermatitis: A reaction that occurs when the skin comes into contact with irritants such as chemicals, soaps, or detergents.
2. Allergic contact dermatitis: A reaction that occurs when the skin comes into contact with allergens, such as nickel, rubber, or poison ivy.
3. Atopic dermatitis (eczema): A chronic skin condition characterized by dry, itchy, and inflamed skin.
4. Psoriasis: A chronic skin condition characterized by red, scaly patches that can occur anywhere on the body, including the hands.
5. Dyshidrotic eczema: A type of eczema that causes small blisters to form on the sides of the fingers, palms, and soles of the feet.
6. Lichen planus: An inflammatory skin condition that can cause purple or white patches to form on the hands and other parts of the body.
7. Scabies: A contagious skin condition caused by mites that burrow into the skin and lay eggs, causing intense itching and a rash.

Treatment for hand dermatoses depends on the specific diagnosis and may include topical creams or ointments, oral medications, phototherapy, or avoidance of triggers.

Scabies is a contagious skin condition caused by the infestation of the human itch mite (Sarcoptes scabiei var. hominis). The female mite burrows into the upper layer of the skin, where it lays its eggs and causes an intensely pruritic (itchy) rash. The rash is often accompanied by small red bumps and blisters, typically found in areas such as the hands, wrists, elbows, armpits, waistline, genitals, and buttocks. Scabies is transmitted through direct skin-to-skin contact with an infected individual or through sharing of contaminated items like bedding or clothing. It can affect people of all ages, races, and socioeconomic backgrounds, but it is particularly common in crowded living conditions, nursing homes, and child care facilities. Treatment usually involves topical medications or oral drugs that kill the mites and their eggs, as well as thorough cleaning and laundering of bedding, clothing, and towels to prevent reinfestation.

Histamine H1 antagonists, non-sedating, also known as second-generation antihistamines, are medications that block the action of histamine at the H1 receptor without causing significant sedation. Histamine is a chemical mediator released by mast cells and basophils in response to an allergen, leading to allergic symptoms such as itching, sneezing, runny nose, and hives.

The non-sedating antihistamines have a higher affinity for the H1 receptor and are less lipophilic than first-generation antihistamines, which results in less penetration of the blood-brain barrier and reduced sedative effects. Examples of non-sedating antihistamines include cetirizine, levocetirizine, loratadine, desloratadine, fexofenadine, and rupatadine. These medications are commonly used to treat allergic rhinitis, urticaria, and angioedema.

Skin irritancy tests are experimental procedures used to determine the potential of a substance to cause irritation or damage to the skin. These tests typically involve applying the substance to intact or abraded (damaged) skin of human volunteers or animals, and then observing and measuring any adverse reactions that occur over a specified period. The results of these tests can help assess the safety of a substance for use in consumer products, pharmaceuticals, or industrial applications. It is important to note that the ethical considerations and regulations surrounding animal testing have led to an increased focus on developing alternative methods, such as in vitro (test tube) tests using reconstructed human skin models.

Contact dermatitis is a type of inflammation of the skin that occurs when it comes into contact with a substance that the individual has developed an allergic reaction to or that causes irritation. It can be divided into two main types: allergic contact dermatitis and irritant contact dermatitis.

Allergic contact dermatitis is caused by an immune system response to a substance, known as an allergen, which the individual has become sensitized to. When the skin comes into contact with this allergen, it triggers an immune reaction that results in inflammation and characteristic symptoms such as redness, swelling, itching, and blistering. Common allergens include metals (such as nickel), rubber, medications, fragrances, and cosmetics.

Irritant contact dermatitis, on the other hand, is caused by direct damage to the skin from a substance that is inherently irritating or corrosive. This can occur after exposure to strong acids, alkalis, solvents, or even prolonged exposure to milder irritants like water or soap. Symptoms of irritant contact dermatitis include redness, pain, burning, and dryness at the site of contact.

The treatment for contact dermatitis typically involves avoiding further exposure to the allergen or irritant, as well as managing symptoms with topical corticosteroids, antihistamines, or other medications as needed. In some cases, patch testing may be performed to identify specific allergens that are causing the reaction.

Dermatomycoses are a group of fungal infections that affect the skin, hair, and nails. These infections are caused by various types of fungi, including dermatophytes, yeasts, and molds. Dermatophyte infections, also known as tinea, are the most common type of dermatomycoses and can affect different areas of the body, such as the scalp (tinea capitis), beard (tinea barbae), body (tinea corporis), feet (tinea pedis or athlete's foot), hands (tinea manuum), and nails (tinea unguium or onychomycosis). Yeast infections, such as those caused by Candida albicans, can lead to conditions like candidal intertrigo, vulvovaginitis, and balanitis. Mold infections are less common but can cause skin disorders like scalded skin syndrome and phaeohyphomycosis. Dermatomycoses are typically treated with topical or oral antifungal medications.

Loratadine is an antihistamine medication that is commonly used to relieve symptoms of allergies, such as hay fever, hives, and other skin reactions. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Loratadine is available over-the-counter in various forms, including tablets, capsules, and syrup.

The medical definition of loratadine is: "A second-generation antihistamine used for the symptomatic treatment of allergies, including hay fever, hives, and other skin reactions. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms."

It's important to note that while loratadine is generally considered safe, it can cause side effects such as dizziness, dry mouth, and headache. If you have any concerns about taking loratadine or experience severe side effects, you should speak with your healthcare provider.

Cosmetics are defined in the medical field as products that are intended to be applied or introduced to the human body for cleansing, beautifying, promoting attractiveness, and altering the appearance. According to the U.S. Food and Drug Administration (FDA), cosmetics include skin creams, lotions, makeup, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, shampoos, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product.

It's important to note that the FDA classifies cosmetics and drugs differently. Drugs are defined as products that are intended to diagnose, cure, mitigate, treat, or prevent disease, and/or affect the structure or function of the body. Some products, such as anti-dandruff shampoos or toothpastes with fluoride, can be considered both a cosmetic and a drug because they have both cleansing and therapeutic properties. These types of products are subject to regulation by both the FDA's Office of Cosmetics and Colors and its Center for Drug Evaluation and Research.

Cosmetics must not be adulterated or misbranded, meaning that they must be safe for use under labeled or customary conditions, properly packaged and labeled, and not contain any harmful ingredients. However, the FDA does not have the authority to approve cosmetic products before they go on the market, with the exception of color additives. Manufacturers are responsible for ensuring that their products are safe and properly labeled.

Erythema multiforme is a skin condition that typically presents as symmetric, red, raised spots or bumps on the skin and mucous membranes. The rash can vary in appearance, but it often has a target-like or irregular shape with central dusky or necrotic areas surrounded by pale rings and red flares. The rash usually begins on the extremities, such as the hands and feet, and then spreads to involve other parts of the body, including the trunk and face.

Erythema multiforme can be caused by various triggers, including infections (most commonly herpes simplex virus), medications, and other medical conditions. The condition is thought to represent a hypersensitivity reaction, where the immune system attacks the skin and mucous membranes.

The severity of erythema multiforme can range from mild to severe, with some cases causing significant pain and discomfort. In more severe cases, the rash may be accompanied by fever, mouth sores, and other systemic symptoms. Treatment typically involves addressing the underlying cause, if known, as well as providing supportive care for the skin lesions. Topical corticosteroids, antihistamines, and pain relievers may be used to help manage symptoms.

I'm sorry for any confusion, but "Succinic Anhydrides" is not a recognized medical term. Succinic anhydride is a chemical compound with the formula (CH2)2(CO)2O. It is used in organic synthesis as a dehydrating agent and acylating agent. If you're asking about a medical application or effect of succinic anhydride or its derivatives, I would need more specific information to provide an accurate and helpful response.

A "drug eruption" is a general term used to describe an adverse skin reaction that occurs as a result of taking a medication. These reactions can vary in severity and appearance, and may include symptoms such as rash, hives, itching, redness, blistering, or peeling of the skin. In some cases, drug eruptions can also cause systemic symptoms such as fever, fatigue, or joint pain.

The exact mechanism by which drugs cause eruptions is not fully understood, but it is thought to involve an abnormal immune response to the medication. There are many different types of drug eruptions, including morphilliform rashes, urticaria (hives), fixed drug eruptions, and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), which is a severe and potentially life-threatening reaction.

If you suspect that you are experiencing a drug eruption, it is important to seek medical attention promptly. Your healthcare provider can help determine the cause of the reaction and recommend appropriate treatment. In some cases, it may be necessary to discontinue the medication causing the reaction and switch to an alternative therapy.

Hypersensitivity, Immediate: Also known as Type I hypersensitivity, it is an exaggerated and abnormal immune response that occurs within minutes to a few hours after exposure to a second dose of an allergen (a substance that triggers an allergic reaction). This type of hypersensitivity is mediated by immunoglobulin E (IgE) antibodies, which are produced by the immune system in response to the first exposure to the allergen. Upon subsequent exposures, these IgE antibodies bind to mast cells and basophils, leading to their degranulation and the release of mediators such as histamine, leukotrienes, and prostaglandins. These mediators cause a variety of symptoms, including itching, swelling, redness, and pain at the site of exposure, as well as systemic symptoms such as difficulty breathing, wheezing, and hypotension (low blood pressure). Examples of immediate hypersensitivity reactions include allergic asthma, hay fever, anaphylaxis, and some forms of food allergy.

Eczema is a medical condition characterized by inflammation of the skin, which leads to symptoms such as redness, itching, scaling, and blistering. It is often used to describe atopic dermatitis, a chronic relapsing form of eczema, although there are several other types of eczema with different causes and characteristics.

Atopic dermatitis is believed to be caused by a combination of genetic and environmental factors, and it often affects people with a family history of allergic conditions such as asthma or hay fever. The condition typically begins in infancy or childhood and can persist into adulthood, although it may improve over time.

Eczema can affect any part of the body, but it is most commonly found on the hands, feet, behind the knees, inside the elbows, and on the face. The rash of eczema is often accompanied by dry, scaly skin, and people with the condition may experience periods of flare-ups and remissions.

Treatment for eczema typically involves a combination of moisturizers to keep the skin hydrated, topical corticosteroids to reduce inflammation, and antihistamines to relieve itching. In severe cases, systemic immunosuppressive drugs may be necessary. It is also important for people with eczema to avoid triggers that can worsen their symptoms, such as harsh soaps, scratchy fabrics, and stress.

I apologize for any confusion, but "Pyroglyphidae" is not a medical term. It is actually a family of small arthropods, specifically mites, that are often found in houses and other buildings. These mites are commonly known as dust mites or storage mites, and some species are associated with allergies and asthma symptoms in humans. If you have any questions related to medical terminology, I'll be happy to help!

Erythema is a term used in medicine to describe redness of the skin, which occurs as a result of increased blood flow in the superficial capillaries. This redness can be caused by various factors such as inflammation, infection, trauma, or exposure to heat, cold, or ultraviolet radiation. In some cases, erythema may also be accompanied by other symptoms such as swelling, warmth, pain, or itching. It is a common finding in many medical conditions and can vary in severity from mild to severe.

An exanthem is a skin eruption or rash that often occurs as a symptom of various diseases, such as infectious illnesses. It can appear in different forms, including maculopapular (consisting of both macules and papules), vesicular (small fluid-filled blisters), petechial (small purple or red spots caused by bleeding under the skin), or erythematous (reddened). The rash can be localized to certain areas of the body or generalized, covering large parts or the entire body. Exanthems are usually accompanied by other symptoms related to the underlying disease, such as fever, cough, or muscle aches.

Urticaria, also known as hives, is an allergic reaction that appears on the skin. It is characterized by the rapid appearance of swollen, pale red bumps or plaques (wheals) on the skin, which are often accompanied by itching, stinging, or burning sensations. These wheals can vary in size and shape, and they may change location and appear in different places over a period of hours or days. Urticaria is usually caused by an allergic reaction to food, medication, or other substances, but it can also be triggered by physical factors such as heat, cold, pressure, or exercise. The condition is generally harmless, but severe cases of urticaria may indicate a more serious underlying medical issue and should be evaluated by a healthcare professional.

Immunoglobulin E (IgE) is a type of antibody that plays a key role in the immune response to parasitic infections and allergies. It is produced by B cells in response to stimulation by antigens, such as pollen, pet dander, or certain foods. Once produced, IgE binds to receptors on the surface of mast cells and basophils, which are immune cells found in tissues and blood respectively. When an individual with IgE antibodies encounters the allergen again, the cross-linking of IgE molecules bound to the FcεRI receptor triggers the release of mediators such as histamine, leukotrienes, prostaglandins, and various cytokines from these cells. These mediators cause the symptoms of an allergic reaction, such as itching, swelling, and redness. IgE also plays a role in protecting against certain parasitic infections by activating eosinophils, which can kill the parasites.

In summary, Immunoglobulin E (IgE) is a type of antibody that plays a crucial role in the immune response to allergens and parasitic infections, it binds to receptors on the surface of mast cells and basophils, when an individual with IgE antibodies encounters the allergen again, it triggers the release of mediators from these cells causing the symptoms of an allergic reaction.

Dermatophagoides are a group of mites that are commonly found in house dust. They are a common cause of allergies and can be found in bedding, carpets, and upholstered furniture. Dermatophagoides mites feed on human skin cells and dander, and their feces and bodies contain proteins that can act as antigens. These antigens can trigger an immune response in some people, leading to the production of antibodies and the release of chemicals such as histamine, which can cause allergic symptoms such as sneezing, runny nose, and itchy eyes.

There are several species of Dermatophagoides mites that are known to cause allergies, including D. pteronyssinus and D. farinae. These mites are very small, measuring only about 0.3 millimeters in length, and are not visible to the naked eye. They thrive in warm, humid environments and are most active at night.

Exposure to Dermatophagoides antigens can occur through inhalation or skin contact. In people with allergies to these mites, symptoms can be triggered by activities such as making the bed, vacuuming, or sleeping on a mattress that is infested with mites. Allergy testing, such as a skin prick test or a blood test, can be used to diagnose an allergy to Dermatophagoides mites. Treatment options for allergies to these mites may include avoidance measures, medications, and immunotherapy (allergy shots).

Patch tests at the U.S. National Library of Medicine Medical Subject Headings (MeSH) "Patch tests (contact allergy testing"), ... The patch test is just induction of contact dermatitis in a small area. Application of the patch tests takes about half an hour ... Foods identified by blood testing or skin prick testing may or may not overlap with foods identified by patch testing. Certain ... Human Repeat Insult Patch Testing (Sensitization and Primary Irritation) 24, 48, 72 Hour Patch Testing Cumulative Irritation ...
... and the patch test is neither sufficient nor necessary for convergence. A broader definition of patch test (applicable to any ... The patch test in the finite element method is a simple indicator of the quality of a finite element, developed by Bruce Irons ... The patch test uses a partial differential equation on a domain consisting from several elements set up so that the exact ... It was long conjectured by engineers that passing the patch test is sufficient for the convergence of the finite element, that ...
Patch test: applying a patch to the skin, where the patch contains the allergen If an immuno-response is seen in the form of a ... Patch testing is used to detect allergic contact dermatitis but does not test for hives or food allergy. Also called an ... The patch test uses rectangles of special hypoallergenic adhesive tape with different allergens on them. The patch is applied ... The British Institute for Allergies About.com - allergy tests Skin Patches (Allergy Testing) (Webarchive template wayback links ...
ISBN 978-3-527-30673-2. Geier, J.; Lessmann, H.; Uter, W.; Schnuch, A. (2005). "Patch testing with phenylmercuric acetate". ...
However, patch testing may be employed to rule out irritants (contact dermatitis) as a cause. In children, nummular dermatitis ... Khurana S, Jain VK, Aggarwal K, Gupta S (December 2002). "Patch testing in discoid eczema". The Journal of Dermatology. 29 (12 ... Krupa Shankar DS, Shrestha S (2005-11-01). "Relevance of patch testing in patients with nummular dermatitis". Indian Journal of ...
It is sometimes used in patch testing in atopic dermatitis. Tixocortol P Larochelle MD, PhD; P Du Souich MD, PhD; E Bolte MD; J ... Nedorost ST, Babineau D (October 2010). "Patch testing in atopic dermatitis". Dermatitis. 21 (5): 251-4. doi:10.2310/6620.2010. ...
Madars, Vitolins (2015-12-05). "EPOLLEXCLUSIVE Linux Kernel patch testing". mvitolin. Retrieved 2020-08-11. "IO Completion ...
A patch test study found that "an increase in the use of DMDM hydantoin in cosmetic products will also inevitably increase the ... "Patch test reactivity to DMDM hydantoin. Relationship to formaldehyde allergy". Contact Dermatitis. 18 (4): 197-201. doi: ...
As well, patch tests are prone to false positives at even low concentrations and not a reliable test. Sensitization to ... A patch test study found that DMDM hydantoin in cosmetic products could increase the risk of cosmetic dermatitis. Some people ... de Groot AC, van Joost T, Bos JD, van der Meeren HL, Weyland JW (1988). "Patch test reactivity to DMDM hydantoin. Relationship ... In 2005-06, it was the 14th-most-prevalent allergen in patch tests (3.7%). Some consumer cosmetics contain quaternium-15 for ...
The allergy can be discovered via a patch test. Eugenol naturally occurs in numerous plants, including the following: Cloves ( ... ISBN 978-3-540-77782-3. Bruynzeel, Derk P. (2014). "Balsam of Peru (Myroxylon pereirae)". Management of Positive Patch Test ...
November 1995). "Patch testing with fragrances: results of a multi-center study of the European Environmental and Contact ... Studies concluded from patch testing show fragrances contain some ingredients which may cause allergic reactions. Balsam of ... de Groot AC, van Joost T, Bos JD, van der Meeren HL, Weyland JW (1988). "Patch test reactivity to DMDM hydantoin. Relationship ... Testing cosmetic products on animals has been illegal in the European Union since September 2004, and testing the separate ...
This can be accomplished by having patch tests, one of various methods commonly known as allergy testing. The patch tests were ... 2009). "Patch-test results of the North American Contact Dermatitis Group 2005-2006". Dermatitis. 20 (3): 149-160. doi:10.2310/ ... The top three allergens found in patch tests from 2005 to 2006 were: nickel sulfate (19.0%), Myroxylon pereirae (Balsam of Peru ... Diagnosis of allergic contact dermatitis can often be supported by patch testing. Contact dermatitis constitutes 95% of all ...
Patch testing has been used successfully to demonstrate tetrazepam allergy. Oral testing can also be used. Skin prick tests are ... Collet E, Dalac S, Morvan C, Sgro C, Lambert D (April 1992). "Tetrazepam allergy once more detected by patch test". Contact ... Barbaud A, Trechot P, Reichert-Penetrat S, Granel F, Schmutz JL (April 2001). "The usefulness of patch testing on the ... Pirker C, Misic A, Brinkmeier T, Frosch PJ (September 2002). "Tetrazepam drug sensitivity -- usefulness of the patch test". ...
... : The Screen Test in 1997; Cabbage Patch Kids: Saturday Night in 1998; and Cabbage Patch Kids: Vernon's ... Their first Cabbage Patch dolls hit the stores in 1995. The Mattel Cabbage Patch dolls were not limited to cloth bodies and ... Official website Cabbage Patch Kid Restoration Official Site Cabbage Patch Kid mania - CBC Digital Archives Urban Legends ... One of Mattel's line of Cabbage Patch Kids dolls, the Cabbage Patch Snacktime Kids, was designed to "eat" plastic snacks. The ...
ISBN 978-0-7216-2921-6. UtaÅŸ S, FerahbaÅŸ A, Yildiz S (2008). "Patients with vulval pruritus: patch test results". Contact ... 56 Patch testing may be used to diagnose the cause. This condition is a symptom of an underlying condition more often than it ...
A patch test Under some patches, the skin has reacted and become inflamed Diagnosis is by patch testing, a method first used in ... If the person being tested has a rash already, it may be difficult to do a patch test. Patch testing may also worsen the ... Diagnosis is by patch test, a method which does not work as well for metals as it does for some other allergens. Prevention and ... For metal allergens, patch test reproducibility is low, and the extent to which they predict implant failures is debated. ...
"Patch 4.0.1 now on Test Realms". MMO-Champion. Archived from the original on September 18, 2010. Retrieved October 4, 2010. " ... Patch 4.3, "Hour of Twilight", was released on November 29, 2011 as the final major patch for Cataclysm. The changes include ... Patch 4.0.1 was released to public test realms, indicating that a release date might be in the not too distant future. On ... Patch 4.0.1, titled "Cataclysm Systems Patch", prepared the game for the changes in the upcoming expansion. It included ...
Specific testing and evaluations using patch testing and allergy tests are best used to determine the irritant causing contact ... Allergy patch skin tests can be used to differentiate allergic contact dermatitis from irritant contact dermatitis and to ... If no relief is found through these initial treatment methods or symptoms have worsened, allergy patch tests should be ... Burkemper, Nicole M. (2015). "Contact Dermatitis, Patch Testing, and Allergen Avoidance". Missouri Medicine. 112 (4): 296-300. ...
Patch testing is used to determine if a specific substance causes allergic inflammation of the skin. It tests for delayed food ... "Patch test in the diagnosis of food allergy". 22 March 2014. Archived from the original on 10 March 2014. Retrieved 31 March ... Balsam of Peru, which is in various foods, is in the "top five" allergens most commonly causing patch test reactions in people ... In these tests, a tiny amount of the suspected allergen is put onto the skin or into a testing device, and the device is placed ...
Kanerva, L.; Jolanki, R.; Alanko, K.; Estlander, T. (July 1999). "Patch-test reactions to plastic and glue allergens". Acta ...
This testing should be performed within one month after resolution of the rash and patch test results are interpreted at ... Diagnosis is often carried out by patch testing. ... blood tests or immunological tests can also be useful. Drug ... Often, several drugs may be causative and allergy testing may be helpful. Sulfa drugs are well known to induce TEN or SJS in ... As such, there are some FDA recommended genetic screening tests available for certain drugs and ethnic populations to prevent ...
Allergy testing uses "patch" testing for contact dermatitis. Systemic therapies include antibiotics, immunomodulators, and ... Tests are performed on blood and tissues that are sent to various laboratories from medical facilities and referring physicians ... Specialists in this field often run their own immunopathology labs.[citation needed] Immunodermatology testing is essential for ...
Kirshner, Isabel (25 August 2010). "A Test of Wills Over a Patch of Desert". The New York Times. Retrieved 12 August 2014. ...
Certain allergens may be diagnosed in a patch test. Foreign objects on the skin are the most common cause of non-pathological ...
A special patch is applied to the surface to be tested, and a specified volume of deionized water is injected under the patch. ... A test patch should be as clean as possible. Contamination of a patch can influence the results significantly. The ISO 8502-6 ... Not being supplied with a certificate that the patches pass this test will render the results obtained by these patches useless ... This annex describes a stress test to ensure patch adhesion and wash ability. ...
Patch testing may be useful to determine the allergy. In some cases regular extensive allergy testing over a long period of ... Patch testing may be useful to determine the allergy. Prevention is by avoiding whatever it is that causes the condition. ... EU can be differentiated from cholinergic urticaria by the hot water immersion test. In this test, the person is immersed in ... The patches of rash may appear on different body parts, with variable duration from minutes to days, and does not leave any ...
A patch test may be ordered, for diagnostic purposes. Treatment differs according to which rash a patient has been diagnosed ...
During her career in the US, she published the first description of cases of Behçet's disease there, introduced patch testing ... In New York she introduced patch testing for industrial employees. At the invitation of Heinrich Adolf Gottron and Urs Walter ... Ollendorff Curth completed her early medical training under Josef Jadassohn, pioneer of patch testing, at the University of ... Jacob, Sharon E.; Herro, Elise M. (2013). "1. Clinical guide introduction". Practical Patch Testing and Chemical Allergens in ...
Grayson, Nathan (August 17, 2016). "Overwatch Test Patch Nerfs Genji, Buffs Mei And Mercy". Archived from the original on March ... O'Conner, Alice (March 19, 2019). "Overwatch patches in Baptiste to patch you up". Rock Paper Shotgun. Archived from the ... Orisa was available on the Public Test Servers on the reveal, and was added to the game for all platforms on March 21, 2017, ... The passive was removed in the April 25, 2023 patch update. His Ultimate ability is the Tree of Life, a construct that can be ...
"A Test of Wills Over a Patch of Desert". The New York Times. Retrieved 12 August 2014. Ben Hartman (22 August 2010). "Poets, ...
  • On the right, a microneedle patch is inserted into a rat's skin to produce microscopic holes for ISF to flow through. (nih.gov)
  • Applying a dissolving microneedle patch. (nih.gov)
  • A dissolving microneedle patch encapsulating a model vaccine (colored pink). (nih.gov)
  • The Food and Drug Administration granted investigational new drug status for the vaccine and novel administration method, allowing Prausnitz and collaborators at Emory University School of Medicine to conduct a study that started last fall using the microneedle patch. (nih.gov)
  • Dr. Mark Prausnitz (r) provides NIBIB staff members with the opportunity to handle a prototype of the microneedle patch. (nih.gov)
  • We wanted to find out if it's true that people would like to get their flu vaccine using a microneedle patch. (nih.gov)
  • 35 percent of them opted to be vaccinated once given the choice of the microneedle patch. (nih.gov)
  • Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment. (nih.gov)
  • Patches with different suspected irritants (allergens) are applied to a person's back and left in place for 48 hours. (news-medical.net)
  • The types of allergens tested in an allergy patch test include hair dye, preservatives, cosmetics, and medications. (news-medical.net)
  • Patch testing helps identify which substances may be causing a delayed-type allergic reaction in a patient and may identify allergens not identified by blood testing or skin prick testing. (wikipedia.org)
  • We sought to determine whether skin patch testing to a panel of foods and food additives may identify food allergens that may be responsible for symptoms of IBS. (ibstreatmentcenter.com)
  • Future research should focus on standardizing the patch test procedure and allergens for topical eye medications," Ahlström said. (medscape.com)
  • Several allergens can be tested at the same time. (medlineplus.gov)
  • On the first visit, small patches of possible allergens are applied to the skin. (nih.gov)
  • There are several ways to test for food allergies: blood tests, challenge tests, skin prick tests (or scratch tests), skin injection tests (or intradermal skin tests), and skin patch testing (or atopy patch tests). (neocate.com)
  • Prick testing is another method used to test for a different type of allergy (type I) associated with hay fever, asthma, and contact urticaria. (news-medical.net)
  • The specific foods used in the test are selected based on the patient's diet, previous allergic reactions, and/or previous skin prick test results. (neocate.com)
  • Prick/puncture testing remains one of the most common and popular methods for allergy testing. (medscape.com)
  • Or it may be used if the skin prick test was negative and the provider still thinks that you're allergic to the allergen. (medlineplus.gov)
  • The skin prick test may also be used to diagnose food allergies. (medlineplus.gov)
  • For an allergen to have definite relevance, the product the patient is exposed to must be tested and also be positive in addition to the test allergen. (wikipedia.org)
  • With patch testing, an allergen is placed on a patch, which is applied to your skin for approximately 48 hours. (neocate.com)
  • Thanks for pointing out that some allergen testing services can last for multiple days. (neocate.com)
  • I'd like to find a good allergen testing service soon because my son has been having some rashes on his arm lately. (neocate.com)
  • Type I immunoglobulin E (IgE)-mediated allergy testing is evaluated by measuring allergen-specific IgE. (medscape.com)
  • Skin testing detects allergen-specific IgE bound to mast cells. (medscape.com)
  • A negative test result means there were no skin changes in response to the allergen. (medlineplus.gov)
  • Date: Thu Jan 21 16:54:45 2021 -0500 spec: Increase meson test timeout 10x Tests time out when building in slow environments, like emulated s390x in Fedora copr. (redhat.com)
  • The study enrolled 318 patients who were patch tested between 2013 and 2021 for suspected allergic contact dermatitis (ACD) from topical eye medications. (medscape.com)
  • Ideally, this patch test will be used to determine the causes of generalized eczema, systemic contact dermatitis, maculopapular rash, acute generalized exanthematous pustulosis, and fixed drug eruption. (news-medical.net)
  • Allergy patch testing is used to screen substances to determine the cause of an allergic skin reaction. (news-medical.net)
  • Patch testing detects allergic contact dermatitis, which is a type IV hypersensitivity reaction. (news-medical.net)
  • The former occurs after the patch is removed but will reduce over the following day, whereas an allergic reaction will develop over several days and is more prominent on day five rather than immediately following patch removal. (news-medical.net)
  • A positive reaction causes an area of itchy, active dermatitis at the site of patch application. (news-medical.net)
  • A patch test relies on the principle of a type IV hypersensitivity reaction. (wikipedia.org)
  • How reliable is abacavir skin-patch testing when deciding whether to restart treatment with abacavir in patients who discontinued that drug because of a suspected hypersensitivity reaction? (medscape.com)
  • Patch testing with 1% to 25% abacavir in a petroleum base applied for a 48-hour period has been reported in 7 individuals with a history of possible abacavir hypersensitivity reaction In each case, skin reactions were observed without systemic symptoms. (medscape.com)
  • Patch testing was performed within 4 months of the suspected abacavir hypersensitivity reaction Five HIV-positive individuals known to tolerate abacavir and 2 HIV-negative controls never exposed to abacavir did not experience skin reactions to patches. (medscape.com)
  • The most commonly-reported reaction from patch testing is minor skin irritation from the tape used to attach the patch to the skin. (neocate.com)
  • Occasionally, patients have a strong positive patch test reaction resulting in more severe irritation, which may take around 4-7 days to resolve. (neocate.com)
  • Use Flector Patch with caution in patients at greatest risk of this reaction, including the elderly, those with impaired renal function, heart failure, liver dysfunction, and those taking diuretics and ACE inhibitors. (nih.gov)
  • Allergy skin tests are used to find out which substances cause a person to have an allergic reaction . (medlineplus.gov)
  • Intradermal tests are not used to test for food allergies because of high false-positive results and the danger of causing a severe allergic reaction. (medlineplus.gov)
  • Allergy testing with skin patches (called patch testing) may be necessary to determine what is causing the reaction. (nih.gov)
  • 20 --------- 2 files changed, 59 insertions(+), 58 deletions(-) diff --git a/test/T590-libconfig.sh b/test/T590-libconfig.sh index 745e1bb4. (mail-archive.com)
  • 2 ++ 1 file changed, 2 insertions(+) diff --git a/plugins/cinterion/tests/test-modem-helpers-cinterion.c b/plugins/cinterion/tests/test-modem-helpers-cinterion.c index 5dc4f96. (freedesktop.org)
  • 10 ++++++++++ 1 files changed, 10 insertions(+), 0 deletions(-) diff --git a/input_driver_test.c b/input_driver_test.c index b050b13. (gnu.org)
  • 3 files changed, 484 insertions(+) create mode 100644 tools/testing/vsock/vsock_perf.c diff --git a/tools/testing/vsock/Makefile b/tools/testing/vsock/Makefile index f8293c6910c9. (lkml.org)
  • PHONY: all test clean diff --git a/tools/testing/vsock/README b/tools/testing/vsock/README index 4d5045e7d2c3. (lkml.org)
  • diff --git a/tools/testing/vsock/vsock_perf.c b/tools/testing/vsock/vsock_perf.c new file mode 100644 index 000000000000. (lkml.org)
  • 400 +++++++++++++++++++++++ 2 files changed, 403 insertions(+) create mode 100644 tests/qtest/sifive-e-aon-watchdog-test.c diff --git a/tests/qtest/meson.build b/tests/qtest/meson.build index e910cb32ca. (gnu.org)
  • sifive-e-aon-watchdog-test'] : []) + qos_test_ss = ss.source_set() qos_test_ss.add( 'ac97-test.c', diff --git a/tests/qtest/sifive-e-aon-watchdog-test.c b/tests/qtest/sifive-e-aon-watchdog-test.c new file mode 100644 index 0000000000. (gnu.org)
  • 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/tools/testing/selftests/bpf/prog_tests/uprobe_autoattach.c b/tools/testing/selftests/bpf/prog_tests/uprobe_autoattach.c index d6003dc8cc99. (openwall.net)
  • There is a better way to skip a test, just return 77. (gnupg.org)
  • Abacavir Skin-Patch Testing - Medscape - Mar 25, 2004. (medscape.com)
  • Christopher Starr, MD, an ophthalmologist at Weill Cornell Medicine, New York City, and a clinical spokesperson for the American Academy of Ophthalmology, told Medscape that patch testing in these cases is often not feasible "for the reasons the authors mentioned in their discussion. (medscape.com)
  • The good news is that no needles are used and patch testing is not painful. (neocate.com)
  • Many diagnostic tests require blood, but NIBIB-funded researchers have developed a skin patch with tiny needles that painlessly collect interstitial fluid (ISF) for testing. (nih.gov)
  • On the left, a close-up view of the skin patch shows nine tiny needles that collect ISF. (nih.gov)
  • The patch is about the size of a dime and has 100 tiny needles that contain flu vaccine. (nih.gov)
  • This bandage-strip sized patch of painless and dissolvable needles can transform how we get vaccinated," says Dr. Roderic I. Pettigrew, director of NIH's National Institute of Biomedical Imaging and Bioengineering. (nih.gov)
  • The vaccine patch consists of 100 solid, water-soluble needles that are just long enough to penetrate the skin. (nih.gov)
  • The research team designed a skin patch with 121 cone-shaped polymer needles that can be filled with a drug encapsulated by nanoparticles. (nih.gov)
  • The unpatched areas will be marked with red/orange depending on the severity of the issue, while the areas secured with patches will be green. (amasty.com)
  • Besides the BeLPT, several other tests for beryllium sensitization (BeS) or CBD severity have been used, or have been proposed for use. (cdc.gov)
  • 2001). For many patients with CBD, results of resting pulmonary function tests, including spirometry values, lung volumes, and carbon monoxide-diffusing capacity (DLCO), are normal but resting and exercise arterial blood gas levels indicate hypoxemia. (cdc.gov)
  • Patients can react differently to substances during a test than in everyday exposure, or to the same test performed at different times. (news-medical.net)
  • Anaphylactic reactions may occur in patients with the aspirin triad and in patients with or without known sensitivity to NSAIDs or prior exposure to Flector Patch. (nih.gov)
  • While the NTP has made a commitment to assess the health hazards posed by exposure to complex mixtures such as dioxin-like chemicals, AIDS therapies, or asphalt fume (Bucher and Lucier, 1997), testing of a formulation in a chronic bioassay is atypical. (nih.gov)
  • Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patches. (nih.gov)
  • The aim of this investigation was to use activated carbon cloth (ACC) patches to study the probability and extent of dermal exposure to benzene and toluene in a shoe factory.Inhalation and dermal exposure loading were measured simultaneously in 70 subjects on multiple days resulting in 113 observations. (nih.gov)
  • Dermal exposure loading was assessed by ACC patches attached to likely exposed skin areas (e.g. the palm of the hand and abdomen). (nih.gov)
  • citation needed] Patch Testing for cosmetic and skincare products can be broken down into a variety of different categories, including the following: Human Repeat Insult Patch Testing (Sensitization and Primary Irritation) 24, 48, 72 Hour Patch Testing Cumulative Irritation Testing Repeat Open Application Testing The dermatologist or allergist will complete a record form at the second and third appointments (usually 48 and 72/96 hour readings). (wikipedia.org)
  • Positive allergy tests demonstrate sensitization but do not always indicate clinical reactivity. (medscape.com)
  • However, beryllium patch testing fell out of favor, in part because of a potential risk of inducing sensitization and a theoretical risk of aggravating underlying disease. (cdc.gov)
  • REGRESSION(r223744): These caused consistent failures in test that existed and were added in the patches. (webkit.org)
  • REGRESSION(r223744): These caused consistent failures in test that existed an. (webkit.org)
  • Angry back" usually in patients with active dermatitis before testing commenced or in those who experience many strong positive reactions. (news-medical.net)
  • The patch test is just induction of contact dermatitis in a small area. (wikipedia.org)
  • Patch testing can be especially useful in diagnosing delayed allergic reactions, non-IgE-mediated food allergies, eosinophilic esophagitis , food allergy-related gastrointestinal symptoms, and food allergy-related atopic dermatitis . (neocate.com)
  • In a recent prospective study published in the journal Contact Dermatitis , researchers at the University of Copenhagen in Denmark advocate for the use of patch testing with ingredients from common ophthalmic medications, supplemented by the medications themselves used as-is, to diagnose these cases. (medscape.com)
  • Patch testing is used for certain people who have long-term or repeated contact dermatitis. (nih.gov)
  • We performed skin patch testing to common allergenic foods and food additives on individuals with a history of or symptoms suggestive of IBS. (ibstreatmentcenter.com)
  • A new study shows that a special skin patch may work as well as a shot with a hypodermic needle. (nih.gov)
  • NIH-funded researchers compared giving the vaccine using the skin patch to the usual flu shot. (nih.gov)
  • The people who got the skin patch didn't report any serious side effects. (nih.gov)
  • More studies will be needed to test the safety and effectiveness of the skin patch. (nih.gov)
  • Researchers created a skin patch to deliver a drug that can convert white fat to calorie-burning brown fat. (nih.gov)
  • A team of researchers led by Drs. Li Qiang of Columbia University and Zhen Gu of the University of North Carolina at Chapel Hill and North Carolina State University set out to design a microneedle skin patch that could switch on fat browning in a targeted region. (nih.gov)
  • The researchers tested the skin patch, which was a little larger than a pencil eraser, on the abdominal fat pads of three groups of normal mice. (nih.gov)
  • Our skin patch appears to alleviate these complications by delivering most drugs directly to fat tissue. (nih.gov)
  • The microneedle skin patch seems promising, but has not been tested in people. (nih.gov)
  • An experimental skin patch test detected abnormal levels of markers for immune function and stress in the sweat of women with histories of depression , NIMH researchers say. (nih.gov)
  • Levels of the chemical, one of several such cytokines tested, were comparable in sweat and blood, suggesting that the skin patch is a reliable measure of these indicators, which increase risk for metabolic and inflammatory illness. (nih.gov)
  • We used patch test-guided avoidance diets to determine whether avoidance alleviates IBS symptoms. (ibstreatmentcenter.com)
  • You may have symptoms such as itching, a stuffy nose, red watery eyes, or a skin rash if you're allergic to the substance in the test. (medlineplus.gov)
  • These symptoms will go away when the patch tests are removed. (medlineplus.gov)
  • Allergy tests are done to find out which substances are causing your allergy symptoms. (medlineplus.gov)
  • Your provider will consider your symptoms and the results of your skin test to suggest lifestyle changes you can make to avoid substances that may be causing your symptoms. (medlineplus.gov)
  • A patch test is a diagnostic method used to determine which specific substances cause allergic inflammation of a patient's skin. (wikipedia.org)
  • When being used to test for food reactions, tiny cups containing small amounts of a pure food are taped to the patient's back. (neocate.com)
  • Patch testing can also be helpful in determining the cause and pathophysiological mechanisms of cutaneous adverse drug reactions (CADR). (news-medical.net)
  • Uncertain reactions refer to a pink area under the test chamber. (wikipedia.org)
  • Anaphylaxis type reactions have been reported with NSAID products, including diclofenac products such as Flector Patch. (nih.gov)
  • Type IV delayed-type hypersensitivity allergy is assessed through patch testing. (medscape.com)
  • Discontinue Flector Patch immediately if abnormal liver tests persist or worsen. (nih.gov)
  • In the future, we could create capture methods for multiple biomarkers all in the same patch. (nih.gov)
  • The researchers say the patch can speed diagnostic testing, is designed to take less effort than previous methods, and can be produced in mass quantities at low cost. (nih.gov)
  • There are three common methods of allergy skin testing. (medlineplus.gov)
  • Methods: The 536 volunteer subjects were genotyped for selected SNPs and patch tested with three model irritants: sodium lauryl sulfate (SLS), sodium hydroxide (NaOH), and benzalkonium chloride (BKC). (cdc.gov)
  • Diagnostic tests can measure trace amounts of essential proteins or hormones in the blood called biomarkers. (nih.gov)
  • Researchers think the ISF patch will simplify diagnostic testing and enable the continuous monitoring of biomarkers. (nih.gov)
  • Then researchers offered four choices for future vaccination: take a patch home and self-administer the vaccine, have a health practitioner supervise the patch vaccination, have the health practitioner administer the patch, or the standard injection. (nih.gov)
  • If your link should fail, you will know it is not caused by poor test reference cords. (flukenetworks.com)
  • Difficulty in applying patches and instances where fixes fail to work properly - or cause unfortunate side effects - have long been an issue in Microsoft shops. (theregister.com)
  • If this bug report was created because of a flaky test, please file a bug for the flaky test (if we don't already have one on file) and dup this bug against that bug so that we can track how often these flaky tests fail. (webkit.org)
  • Approximately 32-50% of drug patch tests are positive in patients who have developed a CADR. (news-medical.net)
  • A positive patch test might not explain the present skin problem, since the test only indicates that the individual became allergic during encounters with that chemical at some point in their life. (wikipedia.org)
  • Relevance, therefore, has to be established by determining the causal relationship between the positive test and eczema. (wikipedia.org)
  • A positive test alone is not sufficient to diagnose an allergic condition. (medscape.com)
  • Thirty of the 51 study participants showed at least 1 doubtful or positive patch test result. (ibstreatmentcenter.com)
  • We are presenting an exceptional case of levofloxacin-induced DRESS without eosinophilia and with positive patch-tests to levofloxacin. (nih.gov)
  • Almost one third of patch-test positive patients had a previous cataract diagnosis (29.3%) and a quarter (24.4%) had glaucoma. (medscape.com)
  • People can have a positive response to a substance with allergy skin testing, but not have any problems with that substance in everyday life. (medlineplus.gov)
  • Positive patches were exclusively observed among subjects performing the task of gluing. (nih.gov)
  • A dime-sized patch of tiny, dissolvable microneedles could be the biomedical advance that expands the reach of vaccines to remote parts of the world and overcomes fear that prevents many from getting a flu shot each year. (nih.gov)
  • [-- Attachment #1: Type: text/plain, Size: 2900 bytes --] Hi Kyle, Thank you for the patch! (kernel.org)
  • View All Add an attachment (proposed patch, testcase, etc. (webkit.org)
  • Created attachment 324417 [details] ROLLOUT of r223744 Any committer can land this patch automatically by marking it commit-queue+. (webkit.org)
  • If you would like to land the rollout faster, you can use the following command: webkit-patch land-attachment ATTACHMENT_ID where ATTACHMENT_ID is the ID of this attachment. (webkit.org)
  • An allergist would be able to help determine the best and most appropriate testing for your son. (neocate.com)
  • In rare recalcitrant and/or severe cases, in which the above strategies failed, then referral to an allergist with the capabilities of patch testing for ocular medications is a reasonable next step," said Starr, who was not involved in the study. (medscape.com)
  • To simplify security management and operations for its customers, Microsoft will reduce the number of patch installer technologies used across the company and offer new security configuration wizards. (theregister.com)
  • PATCH 8/8] Use vfprintf in debug_printf and write to stderr. (gnu.org)
  • Notably, this allergy test cannot be used to identify the cause of urticaria (hives) or food allergy. (news-medical.net)
  • In rare cases, a person may have a negative allergy test and still be allergic to the substance. (medlineplus.gov)
  • The patch is peeled away and discarded like a used bandage strip. (nih.gov)
  • After the 48 hour period, you return to the doctor, who removes the patches and assesses skin irritation (redness and swelling), which may indicate an allergy to the substance applied at that site. (neocate.com)
  • Hello, I attached the test case below as obvious after verifying that it passes. (gnu.org)
  • I've patched and recompiled world + kernel using your patch. (freebsd.org)
  • I applied the patch and recompiled my kernel. (freebsd.org)
  • With these types of food allergies, offending foods are often difficult to pinpoint and are often not detected by other types of allergy testing. (neocate.com)
  • It really helped when you talked about food allergies and their testing options. (neocate.com)
  • more widespread testing before I commit it. (freebsd.org)
  • Diagnostic allergy testing should be considered when a clinical scenario suggests an external, usually harmless, substance is causing pathology. (medscape.com)
  • Aluminum lactate (AL) may be as reliable a test substance as ACH. (nih.gov)
  • As always, this testing schedule is very fluid and subject to the realities of a test environment. (mmo-champion.com)
  • Some described a slight redness or itchiness where the patch had been. (nih.gov)
  • Application of the patch tests takes about half an hour, though many times the overall appointment time is longer as the provider will take an extensive history. (wikipedia.org)
  • We might have to change the time of a testing session, change the bosses being tested, or cancel a test entirely, due to bugs, server hardware issues, etc. (mmo-champion.com)
  • However, the test takes longer than other types of tests so the patient has to wear the patches for 48-hours and must avoid showering, bathing, or significant sweating during this time to ensure the patches stay attached. (neocate.com)
  • So in case you don't plan big updates, it's better to enable patches to save time and effort. (amasty.com)
  • Having two files would enable people to just convert a test or two at a time and go about their merry way. (parrot.org)
  • Might motivate more people to convert tests, who might not have the time to sit down and do 50-150 of them. (parrot.org)
  • Unlike a blood test, which provides a brief snapshot of marker levels at one point in time, the sweat patch test provides a window into these levels over the course of a day. (nih.gov)
  • This results in many false positives to the tested substances. (news-medical.net)
  • Doing this will ensure predictable, accurate test results. (flukenetworks.com)
  • However, the preparation of the fresh food is not standardized, so there is some room for variability in the testing results from one doctor to another. (neocate.com)
  • So even if you're not a tech specialist, you'll be well informed about security test results. (amasty.com)
  • False negative results are a problem," she said, "which in part may be due to the very thin skin in the eye area compared with the thick back skin where the patch test is performed. (medscape.com)
  • Allergy medicines can change the results of skin tests. (medlineplus.gov)
  • This can be done through skin testing (in vivo) testing or with serological tests (in vitro). (medscape.com)
  • Many groups have started using ISF for diagnostic testing, but Mark Prausnitz, Ph.D., a Regents' Professor of chemical and biomolecular engineering at Georgia Institute of Technology, thought the procedure for analyzing ISF could be simplified. (nih.gov)
  • Prausnitz says the patches may enable flu vaccine to be more effective because it interacts with the skin, rather than the muscle layer beneath the skin. (nih.gov)
  • PATCH 5/5] Recreate xkb/keymap/hurd from xkeyboard-config-1.8's xfree86 keymap. (gnu.org)