Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Patient involvement in the decision-making process in matters pertaining to health.
Involvement in community activities or programs.
Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Works about studies that are usually controlled to assess the effectiveness and dosage (if appropriate) of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques. These studies are performed on several hundred volunteers, including a limited number of patients with the target disease or disorder, and last about two years. This concept includes phase II studies conducted in both the U.S. and in other countries.
Community or individual involvement in the decision-making process.
Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Works about clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as RANDOMIZED CONTROLLED TRIALS AS TOPIC.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Persons who are enrolled in research studies or who are otherwise the subjects of research.
Elements of limited time intervals, contributing to particular results or situations.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Planned post-marketing studies of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have been approved for general sale. These studies are often conducted to obtain additional data about the safety and efficacy of a product. This concept includes phase IV studies conducted in both the U.S. and in other countries.
Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
Committees established to review interim data and efficacy outcomes in clinical trials. The findings of these committees are used in deciding whether a trial should be continued as designed, changed, or terminated. Government regulations regarding federally-funded research involving human subjects (the "Common Rule") require (45 CFR 46.111) that research ethics committees reviewing large-scale clinical trials monitor the data collected using a mechanism such as a data monitoring committee. FDA regulations (21 CFR 50.24) require that such committees be established to monitor studies conducted in emergency settings.
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.
A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
A publication issued at stated, more or less regular, intervals.
Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.
Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
Substances that inhibit or prevent the proliferation of NEOPLASMS.
The teaching or training of patients concerning their own health needs.
Earlier than planned termination of clinical trials.
Conversations with an individual or individuals held in order to obtain information about their background and other personal biographical data, their attitudes and opinions, etc. It includes school admission or job interviews.
Voluntary cooperation of the patient in following a prescribed regimen.
A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Activities or games, usually involving physical effort or skill. Reasons for engagement in sports include pleasure, competition, and/or financial reward.
The number of units (persons, animals, patients, specified circumstances, etc.) in a population to be studied. The sample size should be big enough to have a high likelihood of detecting a true difference between two groups. (From Wassertheil-Smoller, Biostatistics and Epidemiology, 1990, p95)
Therapy with two or more separate preparations given for a combined effect.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Published materials which provide an examination of recent or current literature. Review articles can cover a wide range of subject matter at various levels of completeness and comprehensiveness based on analyses of literature that may include research findings. The review may reflect the state of the art. It also includes reviews as a literary form.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Human experimentation that is intended to benefit the subjects on whom it is performed.
Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).
Financial support of research activities.
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
Those factors which cause an organism to behave or act in either a goal-seeking or satisfying manner. They may be influenced by physiological drives or by external stimuli.
Studies designed to assess the efficacy of programs. They may include the evaluation of cost-effectiveness, the extent to which objectives are met, or impact.
The performance of the basic activities of self care, such as dressing, ambulation, or eating.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.
A subspecialty of internal medicine concerned with the study of neoplasms.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine.
The degree to which the individual regards the health care service or product or the manner in which it is delivered by the provider as useful, effective, or beneficial.
Encouraging consumer behaviors most likely to optimize health potentials (physical and psychosocial) through health information, preventive programs, and access to medical care.
Tumors or cancer of the human BREAST.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Activities performed to identify concepts and aspects of published information and research reports.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A regimen or plan of physical activities designed and prescribed for specific therapeutic goals. Its purpose is to restore normal musculoskeletal function or to reduce pain caused by diseases or injuries.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Those individuals engaged in research.
The use of humans as investigational subjects.
Establishment of the level of a quantifiable effect indicative of a biologic process. The evaluation is frequently to detect the degree of toxic or therapeutic effect.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.
Refusal to take part in activities or procedures that are requested or expected of an individual. This may include refusal by HEALTH PERSONNEL to participate in specific medical procedures or refusal by PATIENTS or members of the public to take part in clinical trials or health promotion programs.
Discontinuance of care received by patient(s) due to reasons other than full recovery from the disease.
Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
The giving of drugs, chemicals, or other substances by mouth.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Public attitudes toward health, disease, and the medical care system.
The return of a sign, symptom, or disease after a remission.
An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
The moral obligations governing the conduct of research. Used for discussions of research ethics as a general topic.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The exchange or transmission of ideas, attitudes, or beliefs between individuals or groups.
Attitudes of personnel toward their patients, other professionals, toward the medical care system, etc.
Persons with physical or mental disabilities that affect or limit their activities of daily living and that may require special accommodations.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
The seeking and acceptance by patients of health service.
The interaction of two or more persons or organizations directed toward a common goal which is mutually beneficial. An act or instance of working or acting together for a common purpose or benefit, i.e., joint action. (From Random House Dictionary Unabridged, 2d ed)
Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.
Education that increases the awareness and favorably influences the attitudes and knowledge relating to the improvement of health on a personal or community basis.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
Any type of research that employs nonnumeric information to explore individual or group characteristics, producing findings not arrived at by statistical procedures or other quantitative means. (Qualitative Inquiry: A Dictionary of Terms Thousand Oaks, CA: Sage Publications, 1997)
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Method of measuring performance against established standards of best practice.
A method of data collection and a QUALITATIVE RESEARCH tool in which a small group of individuals are brought together and allowed to interact in a discussion of their opinions about topics, issues, or questions.
Organized periodic procedures performed on large groups of people for the purpose of detecting disease.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Country located in EUROPE. It is bordered by the NORTH SEA, BELGIUM, and GERMANY. Constituent areas are Aruba, Curacao, Sint Maarten, formerly included in the NETHERLANDS ANTILLES.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
Support systems that provide assistance and encouragement to individuals with physical or emotional disabilities in order that they may better cope. Informal social support is usually provided by friends, relatives, or peers, while formal assistance is provided by churches, groups, etc.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
The physical activity of a human or an animal as a behavioral phenomenon.
Hospital or other institutional committees established to protect the welfare of research subjects. Federal regulations (the "Common Rule" (45 CFR 46)) mandate the use of these committees to monitor federally-funded biomedical and behavioral research involving human subjects.
Any deviation of results or inferences from the truth, or processes leading to such deviation. Bias can result from several sources: one-sided or systematic variations in measurement from the true value (systematic error); flaws in study design; deviation of inferences, interpretations, or analyses based on flawed data or data collection; etc. There is no sense of prejudice or subjectivity implied in the assessment of bias under these conditions.
Social and economic factors that characterize the individual or group within the social structure.
A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Diagnostic, therapeutic and preventive health services provided for individuals in the community.
Antibodies produced by a single clone of cells.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
The introduction of error due to systematic differences in the characteristics between those selected and those not selected for a given study. In sampling bias, error is the result of failure to ensure that all members of the reference population have a known chance of selection in the sample.
The giving of advice and assistance to individuals with educational or personal problems.
The interactions between physician and patient.
Behaviors expressed by individuals to protect, maintain or promote their health status. For example, proper diet, and appropriate exercise are activities perceived to influence health status. Life style is closely associated with health behavior and factors influencing life style are socioeconomic, educational, and cultural.
Societies whose membership is limited to physicians.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The smallest continent and an independent country, comprising six states and two territories. Its capital is Canberra.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
An infant during the first month after birth.
A subgroup having special characteristics within a larger group, often bound together by special ties which distinguish it from the larger group.
A course of study offered by an educational institution.
Functions, equipment, and facilities concerned with the preparation and distribution of ready-to-eat food.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
Care which provides integrated, accessible health care services by clinicians who are accountable for addressing a large majority of personal health care needs, developing a sustained partnership with patients, and practicing in the context of family and community. (JAMA 1995;273(3):192)
Organizations which provide an environment encouraging social interactions through group activities or individual relationships especially for the purpose of rehabilitating or supporting patients, individuals with common health problems, or the elderly. They include therapeutic social clubs.
Strategy for the analysis of RANDOMIZED CONTROLLED TRIALS AS TOPIC that compares patients in the groups to which they were originally randomly assigned.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Collaborative process of research involving researchers and community representatives.
The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.
The science and art of collecting, summarizing, and analyzing data that are subject to random variation. The term is also applied to the data themselves and to the summarization of the data.
Confidence in or reliance on a person or thing.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.
Tumors or cancer of the LUNG.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families.
Performance of activities or tasks traditionally performed by professional health care providers. The concept includes care of oneself or one's family and friends.
Informed consent given by a parent on behalf of a minor or otherwise incompetent child.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Persons functioning as natural, adoptive, or substitute parents. The heading includes the concept of parenthood as well as preparation for becoming a parent.
Disease having a short and relatively severe course.
The quality or state of relating to or affecting two or more nations. (After Merriam-Webster Collegiate Dictionary, 10th ed)
Educational institutions.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)
Persons living in the United States having origins in any of the black groups of Africa.
The process of formulating, improving, and expanding educational, managerial, or service-oriented work plans (excluding computer program development).
Revealing of information, by oral or written communication.
Criteria to determine eligibility of patients for medical care programs and services.
The procedures through which a group approaches, attacks, and solves a common problem.
The act or fact of grasping the meaning, nature, or importance of; understanding. (American Heritage Dictionary, 4th ed) Includes understanding by a patient or research subject of information disclosed orally or in writing.
Individuals licensed to practice medicine.
Therapeutic modalities frequently used in PHYSICAL THERAPY SPECIALTY by PHYSICAL THERAPISTS or physiotherapists to promote, maintain, or restore the physical and physiological well-being of an individual.
The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.
Use of plants or herbs to treat diseases or to alleviate pain.
Reduction of high-risk choices and adoption of low-risk quantity and frequency alternatives.
Assessment of psychological variables by the application of mathematical procedures.
Instruction in which learners progress at their own rate using workbooks, textbooks, or electromechanical devices that provide information in discrete steps, test learning at each step, and provide immediate feedback about achievement. (ERIC, Thesaurus of ERIC Descriptors, 1996).
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
The application of modern theories of learning and conditioning in the treatment of behavior disorders.
An enduring, learned predisposition to behave in a consistent way toward a given class of objects, or a persistent mental and/or neural state of readiness to react to a certain class of objects, not as they are but as they are conceived to be.
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
Acquisition of knowledge as a result of instruction in a formal course of study.
Typical way of life or manner of living characteristic of an individual or group. (From APA, Thesaurus of Psychological Index Terms, 8th ed)
The reciprocal interaction of two or more persons.
The integration of epidemiologic, sociological, economic, and other analytic sciences in the study of health services. Health services research is usually concerned with relationships between need, demand, supply, use, and outcome of health services. The aim of the research is evaluation, particularly in terms of structure, process, output, and outcome. (From Last, Dictionary of Epidemiology, 2d ed)
... recording and reporting trials that involve the participation of human subjects.. *FDA: Good Review Practice: Clinical Review ... References classified by statistical topic[edit]. Good clinical practice[edit]. *ICH E6(R2): Good clinical practice [1] is an ... EMA/CHMP/539146/2013 Investigation of subgroups in confirmatory clinical trials *^ a b FDA - Clinical trial endpoints for the ... ICH E10 - Choice of control group in clinical trials *^ CHMP/EWP/2459/02 Methodological issues in confirmatory clinical trials ...
NIH goals and policies for women's health issues and assures that all appropriate clinical trials include the participation of ... At NIH in 1998, Pinn briefed Sarah, Duchess of York, on medical research topics and major health messages regarding women. ...
... clinical trials, etc.). The fellowship is intended to cover up to six months support for salary, travel, or some combination of ... This could take the form of summer programs, participation in smaller prospective studies, or through some other opportunity. ... The society organizes biennial meetings that provides updates on topics such as epidemiology, pharmacotherapy, psychotherapies ... narrow the gap between bipolar research and clinical practice, and ultimately to improve diagnosis, treatment and outcomes for ...
Results of clinical trials are also presented, such as data from a Phase II clinical trial of MT-102 in cancer-related cachexia ... Attendance: A charity dinner is sometimes organised during SCWD Conférences such as in 2011 in Milan with the participation of ... a consensus of statements based on the following topics: Definitions of Cachexia, Sarcopenia and Frailty with a proposal for an ... End-points in clinical trials including Patient-reported outcomes. Nutrition. Endpoint in clinical trials: strengths and ...
... to gain more understanding about what influences potential candidates to consent to participation in any given clinical trial. ... Hoas and Cook categorized their findings into the following main topics: source of funding morally nagging and challenging ... from clinical trials. Clinical trials are experiments done in clinical research. Such prospective biomedical or behavioral ... There have also been a bigger push to protect participants in clinical trials. Rules and regulations of clinical trials can ...
Goals of that second calls are to improve clinical trials success rate, deliver clinical proof of concept, biomarkers and new ... Since then, the IMI has had four funding rounds: the first call had the topic Safety, while the second call was about Efficacy ... Besides the non-competitive financial aspects of participation in IMI projects for academia, this criticism also discusses that ... Goldman, M. (2012). "The Innovative Medicines Initiative: A European Response to the Innovation Challenge". Clinical ...
Clinical trials[edit]. In the US, trends in patient participation have been influenced by a variety of sources and previous ... In 2011 a seminal[peacock term] paper on the topic came out written by Hood and Friend.[48] ... Patient participation can include a broad spectrum of activities for human subjects during clinical trials and has become ... Breaking down Barriers for Patient Participation in Oncology Clinical Trials" (PDF). Journal of Precision Medicine. Kneed Media ...
... the KCE also maintains a clinical research programme in which it selects and funds non-commercial clinical trials. Lastly, the ... It also receives European subsidies for its participation in certain international projects. As of 2017, it has an in-house ... Aside from producing scientific reports on these topics, ... of approximately 10,000,000 euros for its clinical trials ... establishes guidelines for clinical practice and updates them according to the latest scientific evidence (good clinical ...
... interventions that are being tested for weight management in overweight and obese adults in primary care clinical trials.[ ... She contributed to several other topics, including the investigation of the influence of socioeconomic status and stress on ... and the development of theoretically-driven interventions designed to improve screening participation, particularly in ... She completed her PhD in 1986, and in 1987 was promoted to senior lecturer in clinical psychology and consultant clinical ...
... as well as qualifications with respect to the conduct of clinical trials (phase II to IV). The working group "clinical studies ... a topic that still constitutes a main focus of the group. This expertise and focus has led to the participation in many ... Among these trials, many studies were aiming to get a label for the indication of PONV prevention (phase II and III trials). ... Controlled Clinical Trials 2003; 24:736-51 C. C Apfel, P. Kranke, M. H. Katz, C. Goepfert, T. Papenfuss, S. Rauch, R. Heineck, ...
A randomized clinical trial of Merzel's Big Mind process has been carried out as part of a masters thesis "to test the ... an important topic for further exploration is how to master those other aspects. On the other hand, Big Mind may provide a ... The participants appeared to score higher on various measures after participation, but the reported effects may also result ...
... and will allow Orlando Health physicians and patients to be part of clinical trials through UF's clinical research program. ... Participation in the Large Hadron Collider. A team of UF physicists has a leading role in one of the two major experiments ... The topic of the Symposium was, the "Impact of the Southeast in the World's Renewable Energy Future."[139] ... The joint oncology program offers clinical trial collaborations and comprehensive cancer services customized to the patient by ...
To date, no large scale clinical trials have proven benefits of pharmacological treatment. Kemmerer, David (2015). Cognitive ... Communication of basic needs and the comprehension of simple conversations on highly familiar topics, are examples of common ... found the following outcomes were commonly prioritized in therapy: communication, life participation, physical and emotional ... Clinical Aphasiology, 21. Ozeren, A., Koc, F., Demirkiran, M., Sönmezler, A., & Kibar, M. (2006). Global aphasia due to left ...
... recording and reporting trials that involve the participation of human subjects. It was issued by ICH under Good Clinical ... Furthermore, statistical regulatory guidance is found under general topics (e.g. Good Clinical Practice - ICH E6(R2)) and ... and that the clinical trial data are credible. List of guidances for statistics in regulatory affairs Clinical trials Medical ... Statistical Principles for Clinical Trials ICH E7 - Studies in support of special populations: geriatrics FDA - Clinical trial ...
"The Randomized Clinical Trial: For Whose Benefit?", IRB: A Review of Human Subjects Research, v. 7, n. 2, Mar/Apr, 1985. "The ... His curriculum vitae lists more than 90 scholarly articles and book chapters, covering a wide range of topics, with a special ... Selected articles & book chapters "Citizen Participation: Democratic Elitism and Participatory Democracy", The Allocative ... "The Randomized Clinical Trial: A Tragic Dilemma", Proceedings of the Second International Congress On Ethics in Medicine, N.Y ...
... only 8 of these citations were of actual clinical trials. After examining these clinical trials, the authors concluded that ... Articles coauthored by Rath on these topics include: *. Ivanov V, Ivanova S, Roomi MW, Kalinovsky T, Niedzwiecki A, Rath M ( ... Rath was ordered to cease his defamatory remarks "to ensure that the TAC's continued participation in the debate is not ... In 2008, the Cape High Court found the trials unlawful, banned Rath and his foundation from conducting unauthorised clinical ...
... benefits and risks of a clinical trial, agrees to their own participation. National authorities define certain populations as ... ICH Topic E11: Clinical Investigation of Medicinal Products in the Pediatric Population "[2] Archived 2007-06-10 at the Wayback ... The U.S. Food and Drug Administration encourages clinical trials in children in order to ensure the development of safe and ... The term informed assent describes the process whereby minors may agree to participate in clinical trials. It is similar to the ...
... Clinical Trials, has since been merged into PLOS ONE. Following the merger, the company started the PLOS Hub for Clinical ... The Global Participation Initiative (GPI) was instituted in 2012, by which authors in "group-one countries" are not charged a ... PLOS Clinical Trials ISSN 1555-5887; May 2006, later merged into PLOS ONE ... Trials to collect journal articles published in any PLOS journal and relating to clinical trials. ...
A variety of approaches are explored by the journal including: genetic, behavioral, modeling, and clinical trials. In 2015 SAGE ... The JBR publishes scholarly articles, original research, and reviews on a variety of topics all centering around periodicity in ... SRBR believes in the invaluable contributions the participation of a diverse group of researchers brings to its meetings. ...
... clinical trials and biotherapeutics manufacturing. The partnership will stand for five years until requiring renewal. Algonquin ... The issues and topics covered in the publication cover common student concerns such as money, food, friends, gaming, and more. ... and industry to support Aboriginal post-secondary participation. Algonquin College bursaries for Aboriginal, First Nations and ...
It allows for the protection of participants in clinical trials and research studies. The Belmont Report explains the unifying ... something that has become a resurgent topic in recent years. The APA Guidelines have evolved into a more modern approach to ... appropriate guidelines for the selection of human subjects for participation in such research and (iv) the nature and ... Vollmer, Sara H.; Howard, George (December 2010). "Statistical power, the Belmont Report, and the ethics of clinical trials". ...
... on the grounds that in the third phase of Oxford/AstraZeneca's clinical trials too few volunteers over 55 were enrolled; on 8 ... At the beginning of the month, the participation rate among family doctors was about 50-55%. In an effort to boost rural access ... Moldovan President Maia Sandu in the country as part of a collaboration project about the COVID-19 pandemic and other topics ...
The GDCN has initiated or participated in numerous single-center and multicenter clinical trials, epidemiologic studies and a ... Using iTunes®, Falk and colleagues in the UNC Kidney Center have recorded many podcasts covering kidney disease topics that are ... medical records and contact information for the registries allows the GDCN to recruit patients for participation in a variety ... Falk was inducted into the American Society of Clinical Investigation in 1993 and into the American Clinical and Climatologic ...
Developing a conceptual framework for an evaluation system for the NIAID HIV/AIDS clinical trials networks. Health Research ... It combines the ideas of diverse participants to show what the group thinks and values in relation to the specific topic of ... perceptions of barriers to minority participation in medical research: an application of concept mapping. Ethnicity & Health, ... Group concept mapping can be used with any group for any topic of interest. It is often used by government agencies, academic ...
Jüni, P.; Egger, Matthias (2005). "Empirical evidence of attrition bias in clinical trials". International Journal of ... exclusion bias, results from applying different criteria to cases and controls in regards to participation eligibility for a ... personal relation to the study topic and other reasons. As with most instances mitigation in the case of volunteer bias is an ... Early termination of a trial at a time when its results support the desired conclusion. A trial may be terminated early at an ...
Its success in clinical trials during the war years was the basis for the development of the field of anti-cancer chemotherapy ... Cornelius P. Rhoads: An Indictment; he writes on this topic via his blog and personal website. During the 1980s, the Puerto ... With his enthusiastic participation, secret experiments including race-based tests involving African Americans, Japanese ... Gilman A. (1963). "The initial clinical trial of nitrogen mustard". Am J Surg. 105 (5): 574-578. doi:10.1016/0002-9610(63)90232 ...
In 1986, RTI was awarded a $4 million contract with the National Cancer Institute to conduct an eight-year clinical trial on ... RTI research has covered topics like HIV/AIDS, healthcare, education curriculum and the environment, among others. The US ... citizens had almost no experience with local governance or active participation in the governing process. To inform and train ... Two years later, RTI began a $4.4 million program to coordinate AIDS drug trials for the National Institutes of Health. This ...
Status and relevance for clinical trials". Movement Disorders (Review). 33 (4): 528-536. doi:10.1002/mds.27355. PMID 29624752. ... Transparency and recognition of health and legal risks involved in participation. Cell biology[edit]. Main article: Biomarker ( ... Scholia has a topic profile for Biomarker.. Retrieved from " ... "British Journal of Clinical Pharmacology. 59 (5): 491-4. doi:10.1111/j.1365-2125.2005.02435.x. PMC 1884846. PMID 15842546.. ...
Foster suggests that women would have encountered suspicion about their own lives had they used same-sex love as a topic, and ... Two months later, they were found guilty in a jury trial. The producers were fined $200 and the cast received suspended ... welcomed lesbian participation, and a surge of lesbian-themed writing and political activism in the German feminist movement ... Journal of Consulting and Clinical Psychology, 71 (1), pp. 53-61. ...
"Public Domain on Trial in Reiss-Engelhorn Museum vs. Wikimedia et al. - International Communia Association". Communia- ... A Bachelor of Medicine (lääketieteen kandidaatti, medicine kandidat) is allowed to conduct clinical work under the supervision ... In addition, children's participation in early childhood education is a significant promoter of social equality (Kajonoja, 2005 ... Wikipedia articles that may have off-topic sections from January 2019. *Articles that may contain original research from July ...
"Follow up of Thai Adult Volunteers With Breakthrough HIV Infection After Participation in a Preventive HIV Vaccine Trial". ... Bradley's Neurology in Clinical Practice: Expert Consult - Online and Print, 6e (Bradley, Neurology in Clinical Practice e- ... Walker, BD (2007 Aug-Sep). "Elite control of HIV Infection: implications for vaccines and treatment.". Topics in HIV medicine ... Evian, Clive (2006). Primary HIV/AIDS care: a practical guide for primary health care personnel in a clinical and supportive ...
... gene expression or chemical compounds and clinical trial IDs. For clinical trials, PubMed extracts trial IDs for the two ... Clustering results by topics, authors, journals etc., for instance: Anne O'Tate;[36] ClusterMed;[37] ... Such parameters are: Article Type (MeSH terms, e.g., "Clinical Trial"), Secondary identifiers, (MeSH terms), Language, Country ... timely clinical trial registration". J Am Med Inform Assoc. 20 (e1): e169-74. doi:10.1136/amiajnl-2012-001501. PMC 3715364. ...
2016). "Synbiotics for Prevention and Treatment of Atopic Dermatitis: A Meta-analysis of Randomized Clinical Trials". JAMA ... a collection of resources on the topic of food allergies and intolerances ... participation in sports, blood transfusions, cosmetics, and alcohol.[61] ... "Allergy, Asthma & Clinical Immunology. 14 (2): 57. doi:10.1186/s13223-018-0286-1. ISSN 1710-1492. PMC 6157280. PMID 30275847.. ...
"Discordant Financial Conflicts of Interest Disclosures between Clinical Trial Conference Abstract and Subsequent Publication". ... The emergence of open science or open research has brought to light a number of controversial and hotly-debated topics. ... Academia has not yet built digital infrastructures which are equal, comprehensive, multi-lingual and allows fair participation ... Journal of Clinical Psychology. 64 (7): 821-839. CiteSeerX doi:10.1002/jclp.20492. PMID 18425790. Archived ( ...
"Data sharing platforms for de-identified data from human clinical trials". Clinical Trials: 1740774518769655. doi:10.1177/ ... Computer models are used to examine various topics such as how exercise affects obesity, healthcare costs, and many more.[35] ... Common data elements (CDEs) in clinical research[edit]. Ability to integrate data from multiple clinical trials is an important ... Clinical research informatics[edit]. Clinical research informatics (CRI) is an amalgamation of clinical and research ...
The review of 21 studies, including 16 randomized controlled trials, found that unconditional cash transfers may not improve ... and market participation trends.[48] Examples of interventions include decreasing size of classes and providing additional ... "Structural Violence and Clinical Medicine". PLoS Medicine. 3 (10): e449. doi:10.1371/journal.pmed.0030449. PMC 1621099. PMID ... interventions but are unable to accurately reflect effects on public health due to the multi-faceted nature of the topic. While ...
28 July 1998). The Handbook of Clinical Adult Psychology (2nd ed.). Routledge. p. 173. ISBN 978-0-415-07215-1.. ... The DSM-5 emphasized that excessive worrying had to occur more days than not and on a number of different topics.[27] It has ... Long-term trials have shown continued effectiveness without the development of tolerance and additionally, unlike ... and accomplishing participation by making the patient understand the program of treatment. The purpose of this component is to ...
"Clinical Trials and Human Subject Protection - Regulations". Retrieved 2016-11-10.. ... For research on pregnant women and fetuses, condition topics include preclinical risk studies, minimizing risk, no money (or ... In exchange for their participation, the men were promised free medical exams, hot meals and a burial fund. The men were never ... trial, or sentencing." It also applies to the situation where a person becomes a prisoner after the research has started. ...
... searching for reports of certain adverse events within a lengthy journal dataset from patients in a clinical trial) or "green ... In fields that study households, a much debated topic is whether interviews should be conducted individually or collectively (e ... and has been described as a continuum of between participation and observation. In participant observation[28] researchers ... clinical observations)throughout the testing process. Qualitative research is often useful in a sociological lens. Although ...
A 2018 ProPublica analysis found that African Americans and Native Americans were underrepresented in clinical trials for new ... "A new barrier to participation: Heterogeneous application of voter identification policies". Electoral Studies. 29 (1): 66-73. ... Anwar, Shamena; Bayer, Patrick; Hjalmarsson, Randi (2012-05-01). "The Impact of Jury Race in Criminal Trials". The Quarterly ... African-Americans were even underrepresented in trials involving drugs intended for diseases that disproportionately affect ...
Breaksea Island in New Zealand was declared rat free in 1988 after an eradication campaign based on a successful trial on the ... Forceful government control measures, strong public support and enthusiastic citizen participation continue to keep rat ... and other topics that have provided a great benefit for the health and wellbeing of humankind.[citation needed] ... Clinical Infectious Diseases. 27 (6): 1465-1469. doi:10.1086/515016. ISSN 1058-4838.. ...
"NeuroImage: Clinical. 2: 844-853. doi:10.1016/j.nicl.2013.06.009. Retrieved 11 October 2017.. ... Cosbey J, Johnston SS, Dunn ML (2010). "Sensory processing disorders and social participation". Am J Occup Ther. 64 (3): 462-73 ... Related or outdated topics. *Auditory processing disorder. *Deficits in attention, motor control and perception ... Discrete trial training (Lovaas). *Early start denver model. *Pivotal response treatment. *Schoolwide positive behavior support ...
"Expert Review of Clinical Pharmacology. 9 (6): 755-770. doi:10.1586/17512433.2016.1172960. PMC 4917909 . PMID 27045557.. ... Other useful topics mentioned that patients and doctors might discuss include; carefully monitoring and managing activity to ... The report also noted that a focus on exercise programs had discouraged patient participation in other types of physical ... based on two trials.[5][99][100] The US FDA has repeatedly denied commercial approval, citing numerous deficiencies in both ...
... for women's increased labour force participation and slightly reduced participation in care. ... Shyam, Radhey (2009). Clinical Child Psychology. Delhi: Gyan Books. pp. 113-115. ISBN 978-81-7835-761-4. .. ... Please note: What is considered a human right is controversial and not all the topics listed are universally accepted as human ... Right to a fair trial. *Right to family life. *Right to keep and bear arms ...
A randomized clinical trial,[7] published in 2001, investigated the efficacy of spiritual healing (both at a distance and face- ... clinical trial". Pain. 91 (1-2): 79-89. doi:10.1016/S0304-3959(00)00421-8. PMID 11240080.. CS1 maint: Multiple names: authors ... A review of bias in clinical studies concluded that bias can occur at any or all of the seven stages of research.[2] These ... Sackett (1979) catalogued 56 biases that can arise in sampling and measurement in clinical research, among the above-stated ...
Randomized clinical trial were about 1/3 of clinical research articles. However, in 2009 this still represented only 1.5% of ... "FAO Fisheries & Aquaculture - Topics". *^ "FAO National Aquaculture Sector Overview (NASO)". February 1, ... In the first participation of Chinese student in an international student assessment test, the 2009 Programme for International ... worldwide clinical research articles and 1.7% of worldwide randomized clinical trials. Clinical research education for medical ...
Another review asserted that evidence from clinical trials supports the efficacy of physical exercise as a treatment for ... The benefits of regular exercise, physical fitness and sports participation on cardiovascular and brain health are undeniable ... a relative abundance of literature on the theoretical and practical reasons supporting the investigation of this topic has been ... Compliance with prescribed exercise is low in individuals with cachexia and clinical trials of exercise in this population ...
It is not necessary to look at all of them to determine the topics that are discussed during the day, nor is it necessary to ... Non-response or Participation bias: Failure to obtain complete data from all selected individuals. ... but any given trial is likely to overrepresent one sex and underrepresent the other. Systematic and stratified techniques ... Often, volunteers have a strong interest in the main topic of the survey. ...
"Clinical Evidence. 2010: 1411. PMC 3217736 . PMID 21418682.. *^ MedlinePlus , Breast pain Archived 5 August 2012 at ... NIHR Evaluation, Trials and Studies Coordinating Centre. Archived from the original on 29 October 2013. Retrieved 23 June 2013. ... Pregnancy is an important topic in sociology of the family. The prospective child may preliminarily be placed into numerous ... participation in a wide range of recreational activities appears to be safe, with the avoidance of those with a high risk of ...
Sampling or Limited-scale Trial: Where practical, obtaining samples, free trial or a 'test-drive' prior to purchase ... Other topics in consumer behaviour[edit]. The purchase of an up-market sports car carries both financial risk and social risk, ... Fill, C (2013). Marketing communications: Brands, experiences and participation. United Kingdom: Pearson Education Limited.. ... anthropology and clinical psychology. This resulted in a new emphasis on the customer as a unit of analysis. As a result, new ...
For instance, "user trial engineer" may refer to a human factors professional who specialises in user trials.[citation needed] ... NIOSH Topic Page on Ergonomics and Musculoskeletal Disorders. *Office Ergonomics Information from European Agency for Safety ... Isabel A P Walsh; Jorge Oishi; Helenice J C Gil Coury (February 2008). "Clinical and functional aspects of work-related ... The focus shifted from research to participation through advice to engineers in the design of equipment. After 1965, the period ...
For instance, "user trial engineer" may refer to a human factors professional who specializes in user trials.[citation needed] ... "Safety and Health Topics , Ergonomics , Occupational Safety and Health Administration". Retrieved 28 March 2019. ... Isabel A P Walsh; Jorge Oishi; Helenice J C Gil Coury (February 2008). "Clinical and functional aspects of work-related ... The focus shifted from research to participation through advice to engineers in the design of equipment. After 1965, the period ...
Raine, A. (1993). The Psychopathology of Crime: Criminal Behavior as a Clinical Disorder. San Diego, California: Academic Press ... E. Mulvey, MW Arthur, ND Reppucci, "The prevention and treatment of juvenile delinquency: A review of the research", Clinical ... Related topics. *Antisocial personality disorder. *Conduct disorder. *Dark triad. *Flying monkeys. *History of psychopathy ...
See Trivia, and avoid useless statements like "More research is needed". Wikipedia is not a directory of clinical trials or ... To create a new topic, slick [new section] at the top of the page, give the section a title, and leave your comment. New topics ... This organization facilitates participation in the campus ambassador program for those participating in health-related ... For example, the results of an early-stage clinical trial are unlikely to be appropriate for inclusion in the Treatment section ...
The goal of this document is to discuss the evidence and reasons behind disparities in clinical trial participation. We also ... Regardless of the cause, the lack of participation of these groups in clinical trials raises important questions about the ... by the fact that these same groups are often disproportionately affected by the diseases being studied in clinical trials. ... provide a discourse on potential mechanisms to address disparities in clinical trial accrual including the ethical ...
Clinical Trials as Topic. Adolescent Psychology. Patient Acceptance of Health Care. HIV Risk Behaviors. Adolescents. Clinical ... Adolescent Women & Microbicide Trials: Assessing the Challenges & Opportunities to Their Participation. Study Start Date :. ... Several clinical trials of these products have been conducted, but few have tested populations of young women, who may have ... Determining Characteristics and Behaviors of Adolescent Women Regarding HIV Risk and Microbicide Trial Participation. The ...
Participation and Eligibility. Each clinical trial defines who is eligible to take part in the study. Each trial must include ... Search the NHLBI, use the drop down list to select: the entire site, the Health Topics section only, or the News and Resources ... NHLBI Clinical Trials. Browse a list of NHLBI-sponsored clinical trials. NIH Clinical Research Studies. Search for studies ... Clinical Trial Protocol. Each clinical trial has a master plan called a protocol (PRO-to-kol). This plan explains how the trial ...
A randomised controlled trial. Patient Educ Couns. 2016 Jan;99(1):164-8. doi: 10.1016/j.pec.2015.07.016. Epub 2015 Jul 19. ... MedlinePlus related topics: Mental Health U.S. FDA Resources Further study details as provided by Norwegian University of ... Effect of Patient Participation in Mental Health Care. This study has been completed. ... Randomised Controlled Trial on the Effect of Individual User Involvement in a Mental Health Center. ...
The researchers also found that peoples participation in clinical trials was less likely the lower their household income was ... Topic: Diagnosis. *Tags: Early-stage: Stage IA, Early-stage: Stage IB, Early-stage: Stage IIA, Early-stage: Stage IIB, Early- ... Clinical trials show researchers what does and doesnt work in people. Clinical trials also help researchers and doctors decide ... This uncertainty can make it hard to decide if you want to participate in clinical trial. In rare cases, clinical trial ...
OBJECTIVE To determine attitudes of small animal practitioners toward veterinary clinical trials and variables influencing ... their likelihood of participating in such trials. DESIGN Cross-sectional survey. SAMPLE Small animal practitioners with ... CONCLUSIONS AND CLINICAL RELEVANCE Participation in veterinary clinical trials by small animal practitioners and their clients ... Attitudes of small animal practitioners toward participation in veterinary clinical trials J Am Vet Med Assoc. 2017 Jan 1;250(1 ...
Of these patients 66 were previous or current participants in clinical trials (group A), 12 had declined participation in a ... In order to assess attitudes of patients to participation in therapeutic trials 197 patients underwent structured interviews ... Patients attitudes to participation in clinical trials Br J Clin Pharmacol. 1993 Feb;35(2):204-7. ... Of these patients 66 were previous or current participants in clinical trials (group A), 12 had declined participation in a ...
... might seem custom-made for low-income patients with cancer.Participation gives patients access to cutting-edge investigational ... You have already added this topic to your email alerts. Click here to manage your alerts. ... Clinical trial participation rates are notoriously low among patients with cancer.. A previous analysis by Unger and colleagues ... Clinical trial participation rates are notoriously low among patients with cancer.. A previous analysis by Unger and colleagues ...
Women participating in a randomized clinical trial were able to significantly reduce their alcohol intake regardless of ... Topics. ClinicalHealthcare CostHealthcare DeliveryInsurancePolicyTechnologyValue-Based Care ... Clinical Trial Participation Reduces Alcohol Intake, Improves HIV Outcomes in Women Regardless of Treatment Type. @media screen ... Women participating in a randomized clinical trial were able to significantly reduce their alcohol intake regardless of ...
You can learn more about these topics on the FDA webpage "Inside Clinical Trials: Testing Medical Products in People." ... Do clinical trials have possible risks and benefits?. Yes.. Sometimes patients enroll in a clinical trial to get early access ... What else should I know? And where can I find a clinical trial?. Many people volunteer for clinical trials to help others. So, ... NIH also keeps a list of ongoing trials, so you can search for studies at All clinical trials specify who ...
In our hospital, clinical trials have been positively carried out. For participation in trials, hospitals must pass an ... The Clinical Examination Section consists of 12 staff (including 5 part-time workers): 7 in change of sample examination and 5 ... It is important to not only acquire accreditation but also help clinical staff and patients become aware of some changes/merits ... Comparison of derived RIs with clinical decision limits (CDLs) revealed that the upper limits of RIs differed from CDLs ...
... and Clinical Course of Volunteers Who Become HIV-1 Infected During Participation in a Phase III Vaccine Trial of ALVAC-HIV and ... See Studies by Topic. *See Studies on Map. *How to Search. *How to Use Search Results ... Follow up of Thai Adult Volunteers With Breakthrough HIV Infection After Participation in a Preventive HIV Vaccine Trial. The ... All individuals who became HIV-infected after receiving experimental vaccine or placebo in the RV144 clinical trial if they ...
... the role of clinician influence and other factors on decision making regarding participation in a randomized clinical trial ( ... i,Results,/i,. Age of the pediatric patient was related to participation decisions in the RCT such that older children were ... no modifiable characteristics were related to increased participation, indicating that the informed consent process may not be ... Content initiators were also coded in relation to each topic area raised. Past studies achieved between 88 and 93% agreement on ...
Global and US based clinical trial participation. See links on Office of Womens Health (OWH) Research Roadmap and Office of ... High-priority topics, with needs across product lifecycle and relevant demographic groups (e.g., sex, gender, age, race, ethnic ... Complex, adaptive, Bayesian, and other novel clinical trial designs. *Approaches to leveraging large, complex data to inform ... Computer modeling and simulation (e.g., in silico clinical trials and biocompatibility modeling) ...
Clinical trial recruitment is a challenging step toward FDA approval of new treatments for patients across all disease states; ... Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the ... Crohns & Colitis Foundation Launches New IBD Clinical Trials Community to Educate and Support Clinical Trial Participation. ... which confirmed that barriers to clinical trial participation include insufficient awareness of available clinical trials and ...
... and technology company that owns hundreds of digital patient communities and provides technology solutions for clinical trials ... our goal is to simplify the participation of patients and researchers during the entire clinical trial while improving access ... Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the ... and Pinterest to connect patients to clinical trials. They have addressed the clinical trial patient recruitment problem by ...
Panel Discussion Topics:. *Overcoming Challenges of Volunteer Cross Participation. *Quality Assurance Programme in Clinical ...
... educational event and clinical trials. *Submission of proposals to the Heberden Committee for SpA-related topics at our ... The group welcomes participation from all those interested in complex multi-system disease, clinical genetics, rehabilitation, ... This SIG aims to provide updates on recent clinical trials and increase understanding of current assessment of scleroderma ... Consider barriers that must be overcome to support successful clinical trial programmes for cutaneous vascular manifestations ...
Alzheimers Association exec urges clinical trial participation. Paul Sisson. Do plaques building up in the brain cause ... Topics Health Diseases and Illnesses Diseases and Illnesses. S.D., Mexico work to avert health crisis at migrant camps. Two ...
... enrollment in cancer treatment clinical trials is lacking among 13- to 24-year-olds, according to two articles published in the ... While the participation of children in clinical trials has substantially improved childhood cancer survival rates, ... Relevant Topics. While the participation of children in clinical trials has substantially improved childhood cancer survival ... p,FRIDAY, March 28 (HealthDay News) -- While the participation of children in clinical trials has substantially improved ...
Cancer clinical trial gains international attention in The... An international clinical trial on the effectiveness of a high- ... Effects of gender stereotypes on womens competence and participation in physical activity. Facilitators to military mental ... Those are just some of the topics that will be... more * Cancer clinical trial gains international attention in The Lancet ... An international clinical trial on the effectiveness of a high-precision radiation treatment on certain cancer patients, which ...
What Would Help or Hinder Patient Participation in Clinical Trials for Mitochondrial Disease? ... Future clinical research is needed to explore whether the drug, cysteamine bitartrate, will meaningfully benefit patients. ...
... also known as clinical studies or research protocols - are conducted to test whether a new drug, new prevention strategy, or ... Participation is always voluntary. Baylor College of Medicine investigators conduct hundreds of studies, ranging from small, ... Search by Topic. Allergy/Immunology/Rheumatology. Alzheimers Disease. Anxiety. Asthma/COPD. Autism. Bones/Joints/Muscles. ... Clinical trials - also known as clinical studies - are conducted to test whether a new drug, new prevention strategy, or new ...
Richard Schilsky discusses why, especially in the age of precision medicine, trial participation is critical. ... Can low clinical trial enrollment stifle advances in cancer care? Watch as expert Dr. ... Is Clinical Trial Participation Parallel to the Pace of Drug Development?. Topic Areas: Navigating Cancer ... Can low clinical trial enrollment stifle advances in cancer care? Guest clinical trials expert Dr. Richard Schilsky, from the ...
Watch as clinical trial experts debunk common myths and misconceptions. ... Can you participate in a clinical trial if youre a patient insured through Medicare or Medicaid? ... How Do Medicare and Medicaid Impact Clinical Trial Participation?. Topic Areas: Navigating Cancer ... Clinical Trials Clinical Trial Myths Busted: What Is the Value of Diversity in Clinical Trials? Cecelia Mann, Mel Mann, MBA, M. ...
Operation Warp Speed clinical trials have robust participation from diverse subjects, officials say ... Clinical Quality Measures 101 Although quality-reporting programs such as meaningful use provide incentives to help providers ... The project expects two more trials to enter phase three by mid-September, with results… ... Following an independent investigation in a trial participants unexplained illness, the company got the… ...
Specialized Clinical Centers (U24 Clinical Trial Not Allowed) RFA-NS-19-036. NINDS ... Clinical trial expertise, track record, and resources.. *Strong track record of successful collaboration and participation in ... Examples of topics include: 1) communication with the spoke PDs/PIs and research staff; 2) training spoke PDs/PIs and research ... Clinical Trial? Not Allowed: Only accepting applications that do not propose clinical trials Need help determining whether you ...
Read more about The Importance of Clinical Trial Participation. TOPICS+. Radio Terms. Acute Myeloid Leukemia ... The Importance of Clinical Trial Participation. Tuesday, January 10, 2017. Cancer clinical trials provide patients with access ... Patient Perspectives: Cancer Clinical Trials. Tuesday, September 27, 2016. Clinical trials are extremely important in finding ... Encore: Patient Perspectives: Cancer Clinical Trials. Wednesday, March 29, 2017. Clinical trials are an extremely important in ...
  • In this study, the researchers looked at information from clinical trial enrollment at eight cancer clinics across the United States. (
  • The Community is designed to educate patients, caregivers, and healthcare providers about the clinical trial process, its value, and how to address barriers that exist in enrollment. (
  • While the participation of children in clinical trials has substantially improved childhood cancer survival rates, enrollment in cancer treatment clinical trials is lacking among 13- to 24-year-olds, according to two articles published in the April issue of The Lancet Oncology. (
  • Can low clinical trial enrollment stifle advances in cancer care? (
  • On this episode of Frankly Speaking About Cancer, host Kim Thiboldeaux is joined by two guests to discuss barriers to clinical trial enrollment and how we can overcome these barriers to create new cancer treatments. (
  • Specific actions outlined in the National Plan seek to (1) increase enrollment in clinical trials and other clinical research through community, national, and international outreach, and (2) monitor and identify strategies to diversify enrollment in Alzheimer's disease studies. (
  • These 171 unpublished trials had an estimated total enrollment of 299 763 study participants. (
  • In 2005 the International Committee of Medical Journal Editors (ICMJE) required that prospective trials involving human participants be registered prior to the beginning of study enrollment in order to be considered for publication in member journals. (
  • The Tufts Center for the Study of Drug Development report from January 2013 found that 37 percent of clinical trials fail to meet enrollment goals - and 11 percent never enroll a single patient. (
  • Under-enrollment in clinical trials is an especially significant problem for geriatric conditions. (
  • Intercell joined forces with Inclinix, Inc., a North Carolina-based clinical trial enrollment solutions provider, to devise a strategy including partnerships with major travel and tourism websites, as well as a variety of social networking outlets, including Twitter and YouTube. (
  • The active participation in research (or patient engagement in research) can potentially lead to improvement in the credibility of results (higher rates of enrollment and retention) and in their direct applicability to patients (by asking pertinent questions about patient-important outcomes). (
  • The broadened eligibility criteria recommended by ASCO would allow enrollment of patients with another primary cancer if participation in the trial would not interfere with the patient's safety or the efficacy of the therapy being tested. (
  • BIO head Michelle McMurry-Heath discusses group's efforts to increase enrollment of people of color in COVID-19 clinical trials and why New York's task force to give second review to COVID-19 vaccines is "dangerous for patients. (
  • Reduction in drinking associated with improved clinical outcomes in women with HIV infection and unhealthy alcohol use: results from a randomized clinical trial of oral naltrexone versus placebo [published online July 10, 2019]. (
  • IRVINE, Calif. , Dec. 16, 2019 /PRNewswire-PRWeb/ -- StudyKIK, a clinical trial patient recruitment and technology company that owns hundreds of digital patient communities and provides technology solutions for clinical trials, has announced its Patient Engagement & Retention Mobile Application that is fully-customizable per protocol. (
  • Clinical Infectious Disease, 2016. (
  • According to the Food and Drug Administration's 2015-2016 Global Participation in Clinical Trials Report , only 3.4 percent of Americans participated in a clinical trial in 2016. (
  • Nevertheless, the medium- and long-term vision concerning the vaccine options is much clearer than it was in the past with, for example, the creation of a new phase 2-3 preventive trial that began in 2016 in South Africa, the HVTN 702 trial, 1 which follows a vaccination regimen very similar to the one in the Thai RV144 trial. (
  • Although progress in increasing minority participation in clinical trials has occurred, participation rates do not fully represent the overall population of minorities in the United States. (
  • All types of clinical trials contribute to medical knowledge and practice. (
  • The SIG is an opportunity to present and discuss best practice and clinical research relevant to the field. (
  • This article reviews four distinct points from the literature to better understand the current state and application of hsCRP in clinical practice, and we highlight recommendations from societies and important considerations when using hsCRP to guide treatment decisions in the primary prevention setting. (
  • As part of an initiative that aims to prevent 1 million myocardial infarctions and strokes over the next 5 years, we present the simply organized "ABCDE" approach for guiding a consistent comprehensive approach to managing cardiovascular risk in daily clinical practice. (
  • Based on historical records of clinical studies done in the past, inducements for research participants in clinical research through payments may have been a predominant practice for a long time even without the existence of proper guidelines on whether or not the practice of inducement is appropriate and how and in what manner this should be done in clinical research. (
  • We are delighted that you are able to join us today for the webinar to learn about SGLT 2 inhibitors in clinical practice. (
  • Dr. Bajaj serves Diabetes Canada as the co-chair of the communication and marketing portfolio within the professional section national executive as a national consultant editor for the Canadian Journal for diabetes and as an expert committee member for the 2018 clinical practice guidelines. (
  • Emerging rehabilitation approaches for people with dementia encompass a variety of techniques (e.g., task-oriented training, strategy training, individualized goal development) and training methods(e.g., errorless learning) which make the direct translation to clinical practice unwieldy without a standardized approach for evaluating client-centred outcomes, planning individualized interventions and implementing training methods [ 3 ]. (
  • The MFM division works closely with the Alabama Medicaid agency and the Alabama Department of Public Health in development of clinical perinatal practice guidelines. (
  • The society supports the following educational initiatives: The Psychiatric Trainee Support program offers psychiatric trainees a free two-year membership in the society in order to enhance knowledge of bipolar disorder among this group, narrow the gap between bipolar research and clinical practice, and ultimately to improve diagnosis, treatment and outcomes for patients with bipolar disorder. (
  • In later phases of clinical trials, researchers learn more about the new approach's risks and benefits. (
  • Clinical trials show researchers what does and doesn't work in people. (
  • Clinical trials also help researchers and doctors decide if the side effects of a new treatment are acceptable when weighed against the benefits offered by the new treatment. (
  • The researchers followed the people in the study to see if they did enroll in the clinical trial. (
  • The researchers wanted to know if the patients' income was linked to whether people did or did not enroll in the trial. (
  • The identification of patient income level as an independent predictor of trial participation is important for multiple reasons," said the researchers. (
  • Researchers don't know what the results of clinical trials will be. (
  • Through this new application, our goal is to simplify the participation of patients and researchers during the entire clinical trial while improving access to data for the benefit of future trials and participants. (
  • How are researchers helping to facilitate participation by minorities in clinical trials? (
  • At the Alzheimer's Association International Conference (AAIC) 2018, representatives of the National Institutes on Aging (NIA) at the National Institutes of Health (NIH) reported progress on the National Strategy for Recruitment and Participation in Alzheimer's Disease Clinical Research, the effort convened to outline practical, proactive approaches to help study sites and researchers recruit and retain volunteers for Alzheimer's and other dementia research studies. (
  • Alzheimer Europe requests further information on the participation of people with dementia in Phase I drug trials and the use of the concept of 'direct benefit' in placebo trials and wants to encourage an ongoing dialogue between political decision makers, patients' and carers' organisations, the pharmaceutical industry and researchers on this subject. (
  • CISCRP believes research volunteers should know the results of their trial, and wants to make it easier for participants to find out what researchers learned from clinical trials. (
  • They classified the apps in the following categories: helping patients find a trial, helping patients manage their trial activities, helping doctors find trials to recommend, and helping researchers gather and interpret data. (
  • UC San Francisco researchers have completed the first Internet-based clinical trial for children with autism. (
  • A couple years ago, we looked at the question of how researchers and companies decide on compensation for subjects' participation in clinical trials. (
  • If income is associated with health status, then improving representativeness of lower-income patients in trials would improve the generalizability of study outcomes. (
  • For women with unhealthy alcohol use, participating in a randomized controlled trial to cut alcohol use also produces positive spillover effects on HIV outcomes, according to study findings. (
  • We concluded that the coronary artery calcium score was the strongest marker for clinical risk prediction and is the most likely to influence future clinical outcomes. (
  • This randomized controlled trial (RCT) evaluates the effectiveness of Questscope Non-Formal Education (QS NFE) on impacting psychosocial outcomes for out-of-school youth, ages 13-21, in Jordan. (
  • Can engaging in clinical research improve individual health outcomes? (
  • Older adults are often excluded because they have comorbidities that complicate assessment of trial outcomes, mobility issues or supportive care needs, or they take multiple medications that can confound research results. (
  • Over the remainder of 2017, the Foundation will roll out a clinical trial ambassador program, clinical trial communications, and educational tools for Foundation programs and events across the country. (
  • A 2017 study in the Journal of the American Geriatrics Society reviewed 839 trials for ischemic heart disease and found that 53 percent explicitly excluded older adults. (
  • In 2017, the Center for Information and Study on Clinical Research Participation performed a survey showing that 90 percent of patients want to hear about clinical research during visits with their primary physician, yet only 15 percent report being asked to participate in a clinical trial. (
  • This study will examine characteristics and behaviors of young women in India and Tanzania to determine which challenges and opportunities exist for conducting future trials of HIV prevention treatments. (
  • For example, the National Heart, Lung, and Blood Institute (NHLBI) sponsored a trial of two different combinations of asthma treatments. (
  • Clinical trials are an important step in discovering new treatments for breast cancer and other diseases as well as new ways to detect, diagnose, and reduce the risk of disease. (
  • Also, greater participation of lower-income patients would allow trials to be conducted more quickly, speeding the development of new treatments. (
  • Crucially, since clinical trial treatments represent the newest available treatments, access to this vital resource should be available to individuals of all income levels. (
  • A high proportion of respondents were likely or extremely likely to recommend clinical trial participation to clients for their pets when those trials involved treatments licensed in other countries, novel treatments, respected investigators, or sponsoring by academic institutions, among other reasons. (
  • Clinical trials are voluntary human research studies designed to answer specific questions about the safety and effectiveness of drugs, vaccines, devices, and other therapies-or to study new ways of using existing treatments. (
  • Cancer patients are living longer as a result of clinical trials that test new treatments, therapies, procedures, or new ways of using known treatments. (
  • The CF Foundation offers a number of resources for learning about clinical trials and treatments that are being developed to improve the treatment of cystic fibrosis. (
  • By participating in clinical research, you can help to accelerate progress and provide valuable insights into potential treatments and preventions, successful caregiving, and better understanding and managing our Alzheimer's risk. (
  • For trials involving treatments for aging-related diseases and conditions, such as Alzheimer's, participation by older people is important not only because they are more representative of the target population but because it allows the treatment to be fine-tuned for older people. (
  • Clinical trials help to determine if treatments are safe and effective. (
  • With this growing interest in personalized medicine, 'N-of-1' trials offer new potential, particularly for orphan indications and cancer treatments that are prescribed following genetic testing. (
  • A tiny minority of patients who are eligible for clinical trials end up participating in one, and as a result, not only do patients fail to receive treatments that the trials provide, the trial results end up not representing the patients we would treat in the real world. (
  • The latter currently relies on the use of Truvada but many trials are currently in progress or have been completed, which aim to explore the use of injectable treatments. (
  • Each survey included questions designed to collect information on the respondents' willingness to enroll their patients in clinical trials and to recommend participation to clients for their pets. (
  • Sometimes patients enroll in a clinical trial to get early access to what they believe is a promising therapy. (
  • This study will enroll volunteers who become HIV-infected during the course of follow up in a phase III preventive HIV vaccine trial conducted in Rayong and Chon Buri, Thailand. (
  • First you have to find the people who have that genetic abnormalities, then you have to be able to enroll them in a clinical trial. (
  • A hub will typically be a regional medical center that will actively enroll subjects into clinical trials and studies performed in EPPIC-Net. (
  • The National Heart, Lung, and Blood Institute (NHLBI) and other National Institutes of Health (NIH) Institutes and Centers sponsor clinical trials. (
  • NIH Institutes and Centers (including the NHLBI) usually sponsor trials that test principles or strategies. (
  • The purpose of this funding opportunity announcement (FOA) is to invite applications for the Specialized Clinical Centers ("hubs") of the Early Phase Pain Investigation Clinical Network (EPPIC-Net). (
  • This FOA solicits applications EPPIC-Net Specialized Clinical Centers. (
  • in the US involving a review of 467 clinical research studies that offered payment to research subjects and approved by 11 Institutional Review Boards (IRBs) across the US composed [End Page 8] of 7 academic IRBs in medical centers and 4 independent IRBs. (
  • Some of the information needed to characterize the decision process of a drug sponsor came from semi-structured discussions with our team of experts and other industry experts, FDA personnel, drug sponsors, CROs, and primary clinical research centers, including University of Massachusetts, Johns Hopkins University, University of Michigan, and the Mayo Clinic. (
  • Unger said there is little available research on socioeconomic barriers to clinical trial participation, mostly because clinical trials typically do not collect this information. (
  • The Foundation conducted research including a literature review, landscape analysis and focus groups among the IBD patient population, which confirmed that barriers to clinical trial participation include insufficient awareness of available clinical trials and lack of understanding of the process. (
  • The composition of minorities in clinical trials has historical been low. (
  • This workshop will explore the reasons behind the underrepresentation of racial and ethnic minorities in clinical trials and outline potential strategies to address this underrepresentation. (
  • That study's serious flaws led to major changes in how clinical trials are conducted in order to protect the rights, safety, and welfare of patients in clinical trials . (
  • Guest clinical trials expert Dr. Richard Schilsky, from the American Society of Clinical Oncology, discusses why, especially in the age of precision medicine, trial participation is critical to getting reliable data and making treatment research developments. (
  • Clinical trials expert Dr. Richard Schilsky, from the American Society of Clinical Oncology,discusses language and cultural barriers that inhibit access and methods to reduce them to include more diverse populations in trials. (
  • Fred Hutch scientists are presenting new research findings at the American Society of Clinical Oncology (ASCO) Annual Meeting, Delivering Discoveries: Expanding the Research of Precision Medicine , from June 1-5. (
  • This unit introduces the concept of clinical epidemiology and provides students with core skills in clinical epidemiology at an introductory level. (
  • Clinical trials are research studies that explore whether a medical strategy, treatment, or device is safe and effective for humans. (
  • The purpose of clinical trials is research, so the studies follow strict scientific standards. (
  • Clinical trials are research studies that look at how well a new treatment or medical procedure works. (
  • Clinical trials are started only after earlier studies, done with cells or animals, suggest that the new treatment or procedure will help people and also will be safe for people. (
  • Snyder presented a broad overview of recent studies, touching on preliminary findings from a trial of Ban2401, a drug that has shown an ability to reduce brain plaques called. (
  • Clinical trials - also known as clinical studies - are conducted to test whether a new drug, new prevention strategy, or new screening test is safe and effective in people. (
  • Baylor College of Medicine investigators conduct hundreds of studies, ranging from small, short-term studies to large trials with thousands of patients across many institutions. (
  • EPPIC-Net will provide a robust and readily accessible infrastructure for carrying out in-depth phenotyping and biomarker studies in patients with specific pain conditions, and the rapid design and performance of high-quality Phase 2 clinical trials to test promising novel therapeutics for pain from partners in academia or industry. (
  • Clinical vision research projects, including epidemiologic studies, are part of NEI's core strategy for improving visual health and decreasing visual impairment in populations through research on the burden of disease, its causes, diagnosis, prevention, treatment and rehabilitation. (
  • Other studies are helping us better understand risks for dementia and examining best approaches to clinical and long-term care. (
  • In fact, studies show that only 10 to 27 percent of Alzheimer's disease patients are trial eligible. (
  • Primary care physicians may be unaware of research-participation opportunities or have concerns about referring elderly patients to clinical studies. (
  • Many studies require concurrent participation of a study partner-typically a spouse, partner, or adult child. (
  • There are now websites that advertise clinical studies with promises of significant compensation for willing subjects. (
  • There are very few studies that attempted to explain why research participants are being paid for participation in research. (
  • Clinical trials are research studies that test how well new medical approaches work in people. (
  • What Are Clinical Trials and Studies? (
  • Are Clinical Studies for You? (
  • Registry entries for unpublished trials were reviewed to determine whether results for these studies were available in the results database. (
  • Main outcome measures The frequency of non-publication of trial results and, among unpublished studies, the frequency with which results are unavailable in the database. (
  • Since 2011, CISCRP has worked with clinical trial sponsors to provide participants in the certain studies with the results of the research. (
  • Some study sponsors now have a database on their website that contains the technical clinical trial results for their studies. (
  • The clinical studies related to MEDI3902 and of AIC499 will be supported by innovative epidemiological studies, including mathematical modeling of the consequences of P. aeruginosa infections. (
  • Furthermore, detailed biomarker studies will be performed to explore associations of host biomarkers (e.g., pre‐existing antibodies against P. aeruginosa virulence factors, protein biomarkers, and ribonucleic acid (RNA) molecules) and infections, disease severity and outcome, which will enhance the successful execution of clinical trials. (
  • CHICAGO - June 24, 2013 - PRLog -- The Midwest Child & Family Institute has launched a "Sickle Cell Clinical Trials Newsletter" which allows those with Sickle Cell Trait or Sickle Cell Disease to search for and participate in hundreds of sickle cell research studies around the world. (
  • The MC&FI's "Sickle Cell Clinical Trials Newsletter" is a free newsletter consisting of aggregated research studies published by the U.S. National Institutes of Health through its online registry, . (
  • The focus is primarily on initiation of and participation in large national and international clinical trials, especially on rectal and endometrial cancer, and translational research and quality of life studies within the scope of these trials, such as studies on new molecular prognostic factors, decision making, long-term health related quality of life and long-term adverse effects. (
  • The principal investigators are initiators and coordinators of several national and international studies, such as the International rectal cancer study (TME study), the four PORTEC-trials on endometrial carcinoma, and the three trials of the Dutch Bone Metastasis Study Group. (
  • Late outcome, cancer survivorship and quality of life, and translational research studies have evolved from these trials. (
  • All of these trials have led to many side studies, translational work, major international presentations and publications and theses. (
  • In the nearly 40 years since implementation of federal regulations governing the protection of human participants in research, the number of clinical studies has grown exponentially. (
  • These studies have become more complex, with multisite trials now common, and there is increasing use of archived biospecimens and related data, including genomics data. (
  • There are also long-standing concerns about the processes and forms used to obtain informed consent from patients participating in clinical studies. (
  • If you would like to be considered for these or future Miami Project trials or studies, please see our Register for a Research Program section, send us a message , or call The Miami Project Education Office at 305-243-7108. (
  • In addition to participating in the multicenter NICHD-sponsored Maternal-Fetal Medicine Units Network to conduct multi-center clinical trials, members of the division are actively involved in ongoing clinical trials and studies on topics such hypertension in pregnancy, diabetes, preterm birth, and labor management. (
  • For further details on current studies, research endeavors, and participation in these studies, please see the Center for Women's Reproductive Health . (
  • This could take the form of summer programs, participation in smaller prospective studies, or through some other opportunity. (
  • In rare cases, clinical trial volunteers have been hurt by the treatment or procedure being tested. (
  • This protocol will study the clinical course of HIV-infection among volunteers who have received either a placebo injection or the experimental vaccine combination of ALVAC-HIV and AIDSVAX B/E prior to HIV-1 infection in reference to study NCT00223080 RV144. (
  • Extended Evaluation of the Virologic, Immunologic, and Clinical Course of Volunteers Who Become HIV-1 Infected During Participation in a Phase III Vaccine Trial of ALVAC-HIV and AIDSVAX® B/E. (
  • Yet engagement and participation has not kept pace with the acceleration of research and great need for volunteers. (
  • Unfortunately, clinical trial volunteers of any age are scarce. (
  • Millions of study volunteers give the gift of their participation in clinical research each year. (
  • To help solve these issues, CISCRP has developed and tested a program for returning results to study volunteers with an easy to understand summary of the trial results. (
  • CISCRP's program provides an opportunity for the study staff to stay in contact with study volunteers while they wait for the results to be ready with non-promotional, educational communications that shows appreciation for the gift of their participation and values the volunteers as true partners in medical research. (
  • The Austrian drug company is recruiting 1800 volunteers for the phase III clinical trial of a vaccine against enterotoxigenic Escherichia coli -- a major cause of traveler's diarrhea, which affects about 20 million visitors to countries such as Africa, Asia and Latin America, as well as illness in more than 200 million children living in those countries each year. (
  • This research involves the participation of thousands of volunteers, many of whom are vulnerable due to high levels of poverty, low education and low levels of empowerment. (
  • Since its inception, a major weakness in clinical trial research has been an inability to recruit diverse populations into clinical trials. (
  • Several clinical trials of these products have been conducted, but few have tested populations of young women, who may have different characteristics or behaviors from other women. (
  • Participation is especially low for certain populations, including adults age 75 or older and people from certain racial and ethnic groups. (
  • So it is important for patients in those populations who are more likely to be treated for a condition to be included in a trial. (
  • She helps share information about access to care treatment and inclusion in clinical trials for underserved populations. (
  • The objective of the study is to understand vision and balance stability and prevent falls in clinical populations. (
  • Drugs and other interventions to hit those targets are moving into clinical trials. (
  • Clinical trials depend on the willingness of participants to expose themselves to the risks of randomization, blinding, and unproven interventions. (
  • Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions. (
  • The clinical trials are testing the safety and efficacy of different neuroprotective, repairative, or modulatory interventions. (
  • Age of the pediatric patient was related to participation decisions in the RCT such that older children were more likely to be enrolled. (
  • Given the profound and sometimes clinical levels of distress that surrogates (i.e., parents or legal guardians) of children in pediatric intensive care units (PICU) experience [ 15 ], it is important to understand what factors may be influencing the decision making process beyond the informed consent process. (
  • A different type of immunotherapy, chimeric antigen receptor T cell (CAR T) therapy, was the main focus of the SU2C-St. Baldrick's Foundation Pediatric Cancer Dream Team, whose robust clinical trial portfolio includes 18 CAR-T clinical trials involving almost 500 pediatric cancer patients. (
  • Fellowship trainees will participate in several clinical and academic activities, including general pediatric dermatology clinics, several interdisciplinary clinics, procedural dermatology clinics, a busy hospital-based inpatient consultation service, subspecialty electives, and divisional and institutional conferences. (
  • Fellows will also have opportunities within the Division of Pediatric Dermatology for clinical research. (
  • Pediatric dermatology clinical trials are conducted in coordination with a research coordinator and the Clinical Trials Office staff under attending physician guidance as principal investigator. (
  • Goldberg SV, Sterling TR, for the International Maternal Pediatric Adolescents Aids Clinical Trials Group, and the Tuberculosis Trials Consortium. (
  • Fellows are exposed to the breadth of management including adult and pediatric patients, systemic and local immunosuppression, including the use of biologics, clinical trial options, as well as surgical options. (
  • StudyKIK now offers pharmaceutical companies a patient-designed and research site-focused engagement & retention mobile application for patients that randomize into a clinical trial to address the concern of patients dropping out of a trial or losing interest. (
  • StudyKIK's Patient Engagement & Retention Application provides a user-friendly technology for clinical trial participants that are randomized into clinical trials. (
  • StudyKIK's Chief Strategy Officer Sam Haiden stated, "StudyKIK's new patient retention & engagement app will revolutionize the way patients and research sites interact during a clinical trial. (
  • This HIPAA and GDPR compliant Patient Engagement & Retention App further advances StudyKIK's core mission of ensuring that patients feel as supported as possible when going through the clinical trial process all while speeding up patient recruitment and study completion. (
  • Calling All Patients Sign up for our Patient Engagement Hot Topics Webinar that de-mystifies clinical trial participation on Tuesday, April 23. (
  • Find carefully-curated clinical trial innovation and patient engagement information inside. (
  • Joseph M. Unger, PhD, health services researcher and biostatistician at Fred Hutchinson Cancer Research Center in Seattle, and Mark E. Fleury, PhD, principal of policy development and emerging science at American Cancer Society Cancer Action Network, asked what could be done to increase low rates of cancer clinical trial participation, particularly among patients with socioeconomic challenges. (
  • Clinical trials are a key research tool for advancing medical knowledge and patient care. (
  • Five years ago, Unger and colleagues created a questionnaire to explore patient-reported socioeconomic issues, and the data showed that Americans who make less than $50,000 per year are 30% less likely to participate in clinical trials than those with higher incomes. (
  • The IBD Clinical Trials Community has been created to educate about and raise awareness of clinical trials among patients and caregivers, provide resources to identify and participate in relevant clinical trials, and support and improve patient and provider communication about engaging in clinical trials. (
  • The Community will be implemented using a phased approach beginning with the launch of the new website , including an educational video series, patient stories, an IBD clinical trial finder, and research updates. (
  • This technology has been built to strengthen StudyKIK's quest in being able support clinical trials in a single platform from the earliest moment when a patient begins to learn about a clinical trial, to their Screening & Consent, and now from Randomization all the way through Study Completion. (
  • Patient support, trial adherence, and study completion rates will increase from patients being regularly engaged and connected to their clinical trial with this new technology. (
  • More about StudyKIK: StudyKIK is a patient recruitment and technology platform that was founded on patient communities on all major social media channels to increase awareness for clinical trials. (
  • Servicing over 3,600 research sites, StudyKIK owns hundreds of social media patient and caregiver communities across Instagram, Snapchat, Facebook, Twitter, and Pinterest to connect patients to clinical trials. (
  • They have addressed the clinical trial patient recruitment problem by building the technology solutions needed for research sites and pharmaceutical companies to access, manage, and communicate with high-quality patients in real-time. (
  • What Would Help or Hinder Patient Participation in Clinical Trials for Mitochondrial Disease? (
  • Are Clinical Trial Designs Becoming More Patient-Friendly? (
  • Patient advocate and the longest-living #Gleevec survivor Mel Mann also shares his clinical trial experience with a breakthrough chronic myeloid leukemia (CML) therapy. (
  • Can you participate in a clinical trial if you're a patient insured through Medicare or Medicaid? (
  • Learn the ins and outs of clinical trial participation for Medicare and Medicaid patients in this informative panel discussion between Patient Power Lung Cancer Community Manager Laura Levaas, Dr. Mark Fleury of the American Cancer Society Cancer Action Network, Jeanne Regnante of the Diverse Cancer Communities Working Group, Sustainable Healthy Communities, LLC, and Nurse Navigator Laura McHugh from the Baptist Cancer Center in Memphis, Tenn. (
  • Hello, and welcome to this Patient Empowerment Network Clinical Trial MythBusters program on a very, very important topic, what impact does Medicaid or Medicare have on a patient's ability to participate in a clinical trial? (
  • When a patient participates in a clinical trial they are helping to move cancer treatment forward and provide hope for the future of cancer care. (
  • This paper outlines eight aspects of inpatient glucose management (four as system-based issues and four as patient-based issues) in which randomized clinical trials are needed, and urges further progress in the science of inpatient diabetes management. (
  • Patient advocate and the longest living #Gleevec survivor Mel Mann also shares why it's critical for patients to research clinical trials and explore all of their treatment options. (
  • Are Clinical Trials Available to the Older Patient Population? (
  • The terms 'patient-centered' and 'patient-centric' seem to have entered the clinical trial lexicon in full force. (
  • The Patient-Centered Clinical Trials conference is September 4-5 in Boston, MA. (
  • In some instances, a patient with multiple myeloma may be eligible for a stem cell transplant or participation in a clinical trial. (
  • This website is an index of educational and reference material concerning clinical trials including links to fact sheets, basic facts about clinical trials, guides to finding a cancer treatment trial,and patient protection information. (
  • There are also sections of the website which include links pertaining to Educational Materials for becoming a clinical trial investigator, Patient Care Costs, Special Topics, and NCI Programs That Conduct Clinical Trials. (
  • In addition to summarizing these topics, we provide a suggested integrated IBC-specific plan of care that could be provided to the patient at the beginning of care and referred to throughout treatment and follow-up. (
  • Conversely, information derived from clinical trials improves patient care. (
  • With the growing global epidemic of Alzheimer's disease and other dementias, and the recent string of negative clinical trial results, the urgency to correct this situation has never been greater. (
  • Perhaps most fundamental is the need to understand, in a careful and sensitive way, what motivates and facilitates - or impedes - participation by individuals from diverse communities in Alzheimer's and other dementias research," said Marie A. Bernard, MD, geriatrician and Deputy Director of the NIA. (
  • Ironically, the recent public funding increases for Alzheimer's disease and related dementias over the last several years have brought the issue of trial recruitment to a critical point. (
  • To address this pressing issue, the National Institute on Aging has partnered with a wide range of stakeholders to develop a comprehensive National Strategy for Alzheimer's Disease Clinical Trial Recruitment and Participation . (
  • The Alliance works with partner organizations and government agencies such as FDA and NIH to increase older adult participation in clinical trials, including for diseases such as Alzheimer's disease. (
  • Dr. Alessandra Ferrajoli, from The University of Texas MD Anderson Cancer Center, also shares what clinical trial inclusion criteria is typically based on. (
  • Participation gives patients access to cutting-edge investigational therapies and hope for life-prolonging treatment that otherwise would be unavailable. (
  • Cancer clinical trials provide patients with access to new therapies. (
  • The impact of low participation impedes progress toward generating study results, keeping potentially effective therapies achingly further away from people with and at risk for dementia, and their caregivers. (
  • Fellows will have the opportunity to work with well-renowned and experienced clinical faculty with disparate backgrounds in ophthalmology and rheumatology and will learn all aspects of care for the treatment of patients with uveitis and ocular inflammation, including the prescription and management of a wide array of local and systemic immune modulating therapies and surgical management of uveitic cataracts. (
  • It will accelerate accrual to these clinical trials and will bring new therapies to these patients more quickly. (
  • Federal legislation has sought to increase the representation of minorities and women in clinical trials, but legislation by itself has not been sufficient to overcome the many barriers to greater participation. (
  • 1. In order to assess attitudes of patients to participation in therapeutic trials 197 patients underwent structured interviews conducted by a single observer. (
  • In addition to the investigation of therapeutic strategies, the Ovarian Dream Team is opening a trial on cancer prevention. (
  • The VOYAGER PAD trial is the first and only study of antithrombotic therapy in the past 20 years to demonstrate a significant benefit in patients with peripheral artery disease after lower-extremity revascularization,' said James List , M.D., Ph.D., Global Therapeutic Area Head, Cardiovascular & Metabolism, Janssen Research & Development, LLC. (
  • Ken has held a number of board appointments in the private and public sectors, including serving on the Institute of Medicine's Clinical Research Roundtable, the DIA Foundation, the Consortium to Examine Clinical Research Ethics, and the Clinical Trials Transformation Initiative. (
  • Some examples are the work performed at the Massachusetts Institute of Technology (MIT) Center for Biomedical Innovation and the Clinical Trials Transformation Initiative (CTTI), a public-private partnership organization hosted by Duke University. (
  • However, when the physician profits both professionally and financially from the patient's participation in a clinical trial, the situation may become ethically tenuous for the involved physician. (
  • Clinical trials, like the two described above, help improve and advance medical care. (
  • In group A, 62% stated their motivation for participation was to help others and 39% to improve their own treatment, but in 38% participation was to comply with the doctor's request. (
  • Women participating in a randomized clinical trial were able to significantly reduce their alcohol intake regardless of medication assignment and subsequently improve rates of viral suppression. (
  • For women who drink more than 7 drinks per week or more than 3 drinks per occasion, study participation helped them improve viral suppression. (
  • The AYA SIG is linked closely to the Barbara Ansell National Network for Rheumatology (BANNAR), a multidisciplinary, national network of professionals working in both paediatric and adolescent rheumatology that provides a focus for resources to improve both research into, and clinical care for, adolescents and young adults. (
  • Only much broader changes will bring about the meaningful participation of all population groups in the clinical research needed to improve health. (
  • The premier education and networking event for clinical research professionals, ACRP 2021 is the ideal venue for learning the practical strategies, best practices, and creative solutions needed to improve clinical trial quality. (
  • In 2012 J&J formed the Clinical Trial Innovation (CTI) group, which is tasked with developing solutions to modernize clinical trials, improve data quality, and enhance the clinical trial process for patients and investigators. (
  • Aerobic exercise and/or resistance training programs have been shown to improve cardiorespiratory fitness [ 15 - 18 ] and muscle strength [ 19 - 22 ] in overweight/obese adolescents in many controlled trials. (
  • Of these patients 66 were previous or current participants in clinical trials (group A), 12 had declined participation in a trial (group B), and 119 had never been invited to participate in research (group C). 2. (
  • Participants in clinical trials can spend weeks, months, or even years making regular visits to a research site, keeping a log of their symptoms and treatment reactions, and getting checked and examined. (
  • Levinsky ( 2 ) has recently pointed out that the deaths of three research participants in clinical trials were not related to financial factors at all. (
  • Join the Society of Interventional Radiology for the first meeting of a new series on venous thromboembolism (VTE), focusing on clinical approaches to pulmonary embolism (PE), deep vein thrombosis (DVT), and IVC filters. (
  • Patients need better access to trials in their communities, and trial eligibility criteria need to be streamlined or modernized to make trials more accessible to patients with well-managed comorbid conditions. (
  • Aside from eligibility issues, the most significant barrier to older adults' participation in research is that medical providers are not discussing clinical trials or recommending participation with their patients. (
  • CHICAGO - The use of expanded eligibility criteria would allow nearly twice as many people with non-small cell lung cancer to participate in clinical trials, according to data presented at ASCO Annual Meeting. (
  • Opening up clinical trial eligibility would allow more patients to participate in clinical trial research, and the data generated will be more generalizable to the population of individuals that we see in the clinic," R. Donald Harvey, PharmD, BCOP, FCCP, FHOPA, director of the Winship Cancer Institute's phase 1 clinical trials section and associate professor at Emory University School of Medicine, said during a press conference. (
  • That's why diversity in clinical trials is essential. (
  • Clinical Trial Myths Busted: What Is the Value of Diversity in Clinical Trials? (
  • The third phase will be a pilot clinical study that addresses the second two goals by asking participants to undergo evaluations over time, similar to the way they would have to in a microbicide trial. (
  • What phase is this trial? (
  • In my case, I was in a trial related to chronic lymphocytic leukemia, three-drug combination, and I received that in a Phase II trial 10 years before that was approved. (
  • AstraZeneca resumes Phase 3 COVID-19 vaccine trial in the U.K. (
  • One ongoing trial is testing a form of Vitamin D. Dr. Reid, in collaboration with Candace Johnson, PhD and Donald L. Trump, MD, has obtained NCI funding to conduct a phase I toxicity study and a randomized, placebo controlled phase II clinical trial to supplement high risk current and former smokers with confirmed premalignant lesions of the lung. (
  • and (vi) performance of large definitive Phase 3 randomized controlled trial (RCT) for regulatory purposes. (
  • PreP is currently the most advanced path because it has already been proven to be effective in several phase 2-3 trials. (
  • The search strategies differed for each category of literature and related database, but each query employed search terms in various combinations using logic strings, such as "clinical trial AND cost*," "barrier* AND clinical trials," "phase 1 clinical trial* AND cost*,"etc. (
  • The U.S. Food and Drug Administration does not ordinarily conduct clinical trials. (
  • All it takes is your participation in a clinical trial for a diarrhea vaccine. (
  • What are the characteristics of the vaccine trial in South Africa? (
  • The only clinical trial of an HIV vaccine that has yielded interesting results to date is the RV144 trial 2 (a trial combining the use of a canary pox vector coding for the gag, pol, and env and gp120 envelope proteins, which reduced infections by 31.2% 3.5 years after vaccination). (
  • Trial diversity is among the issues that stakeholders worry could hinder vaccine uptake. (
  • The results from other clinical trials show what doesn't work or may cause harm. (
  • What were the results of any previous trials? (
  • RESULTS More than 80% of respondents to each survey indicated that they spend no time in clinical research. (
  • A flagship liver disease drug from San Diego's Conatus Pharmaceuticals failed to meet its main objective in a mid-stage trial, according to results released this week. (
  • Results will also be disseminated to trial participants via workshops led by lay coapplicants. (
  • Objective To estimate the frequency with which results of large randomized clinical trials registered with are not available to the public. (
  • Data sources PubMed, Google Scholar, and Embase were searched to identify published manuscripts containing trial results. (
  • Results Of 585 registered trials, 171 (29%) remained unpublished. (
  • Of the 171 unpublished trials, 133 (78%) had no results available in (
  • Conclusions Among this group of large clinical trials, non-publication of results was common and the availability of results in the database was limited. (
  • A substantial number of study participants were exposed to the risks of trial participation without the societal benefits that accompany the dissemination of trial results. (
  • The clinical trial results are typically ready one year after the end of the trial. (
  • Also sometimes the trial results are written in technical language that is hard to understand. (
  • Over two dozen study sponsors have collaborated with CISCRP to create these Trial Results Summaries. (
  • It is our hope that, eventually, study sponsors will regularly return the results of all clinical trials to study participants in a way that is understandable for the patients, their families, and their caretakers. (
  • Click below to read about CISCRP's Communicating Trial Results Program and view some of the Trial Results Summaries that CISCRP has created. (
  • The U.S. National Institute of Health (NIH) requires that many clinical trial results be posted on the website . (
  • To find results and other information about a specific trial, the NCT# of that trial will be most helpful. (
  • Eli Lilly's Clinical Open Innovation (LCOI) team searched for clinical trial apps and shared their results in a blog post. (
  • The absence of structured conferences to discuss autopsy results may also limit the vital feedback of information, which may explain the clinical course in one case and prompt a more rigorous pursuit of a post mortem in the next. (
  • The question was then raised of the reproducibility of the results of this trial and its transposition elsewhere in the world, particularly in Africa. (
  • Results from traditional clinical trials performed in controlled settings on a tightly defined group of individuals have limited relevance in real-world health care settings. (
  • Group C patients who stated they would not participate in trials gave being too ill (22%), not wanting to change treatment (22%), and fear of side-effects (17%) as the commonest reasons for declining. (
  • Structural and clinical barriers were the reasons why three out of four patients do not participate in trials," he told HemOnc Today . (
  • Overall, few people actually sign up for and participate in trials, and those who do participate don't always represent the U.S. population. (
  • Do clinical trials have possible risks and benefits? (
  • But clinical trials also can carry serious risks-an important fact to consider. (
  • Participants learn about known risks during the informed consent process, but sometimes risks are not known until clinical trials are under way or completed. (
  • The ethical justification for these risks is that society will eventually benefit from the knowledge gained from the trial. (
  • 1 Because the risks involved in trial participation may be significant, and because individual trial participants often do not benefit directly from trial participation, substantial safeguards have been implemented to protect the interests of study participants both prior to and during the trial. (
  • This mobile application has been developed to address the industry problem of retaining those that join a clinical trial but drop out at some point after their participation has begun. (
  • Why Should I Join a Clinical Trial? (
  • Efforts should be increased to raise practitioner awareness of clinical trials for which patients might qualify. (
  • We encourage conference participation by trainees with a strong commitment to clinical care and therapy development in neuromuscular disease. (
  • The School is aimed at clinical trainees (FY1-ST4) interested in an introduction to cutting-edge research relevant to psychiatric disorders. (
  • Search the NHLBI, use the drop down list to select: the entire site, the Health Topics section only, or the News and Resources section. (
  • The median time between study completion and the final literature search was 60 months for unpublished trials. (
  • Prospective cohort study of the clinical course of HIV-1 infection occurring after candidate HIV-1 vaccination (breakthrough infection) with ALVAC-HIV (vcP1521) and AIDSVAX B/E in reference to study NCT00223080 RV144. (
  • Prospective presenters may submit abstracts on any topic focused on neuromuscular diseases. (
  • Significant barriers to participant recruitment for clinical research (CR) are related to effective communication, and nurse coordinators are entrusted with being knowledge brokers between investigators and prospective participants. (
  • We also provide a discourse on potential mechanisms to address disparities in clinical trial accrual including the ethical considerations of financial incentives, the impact of a more stringent policy and review process for product approval from the Food and Drug Administration (FDA) including a diversity mandate with an associated population black box warning. (
  • Between 1996 and 2002, blacks represented on average 9.3% of the total number of enrollees in cancer clinical trials [ 1 ]. (
  • Looking at oncology, more than 60 percent of all cancer cases are diagnosed in people ages 65 and older but only 25 percent of clinical trial enrollees are from that age group, according to a study in the Journal of Clinical Oncology . (
  • And so, certainly, if you're in good physical condition, regardless of your age, then certainly, you're eligible for a clinical trial, so it's a great question. (
  • AIDS Clinical Trials Group A5295 and Tuberculosis Trials Consortium Study 34 Teams. (
  • Since medical products are developed globally (with many clinical trials conducted outside the United States), these trials may not include the diversity of the U.S. population. (
  • This will include interaction with both clinical and administrative staff on a regular basis, instruction in proper coding and billing at time of service, education on issues related to insurance coverage such as prescription drug formulary usage and pre-certification for procedures and other services, and education in facilitating coordination of care with referring providers and other subspecialty care providers. (
  • A complete diagnostic evaluation should include a newborn screening, a sweat chloride test, a genetic or carrier test, and a clinical evaluation at a CF Foundation-accredited care center. (
  • Clinical responsibilities for the fellow include attendance of faculty uveitis clinics and conducting clinics for clinical research participants. (
  • The office helps establish NIH goals and policies for women's health issues and assures that all appropriate clinical trials include the participation of women. (
  • Can Low Clinical Trial Participation Inhibit Cancer Research and Innovation? (
  • There is a low-hanging fruit opportunity in Medicare that would accelerate health innovation: incentivize providers to counsel older adult beneficiaries about clinical trials. (
  • He is the author of two nationally recognized books for patients and their advocates including The Gift of Participation , and the recipient of several awards for innovation and scholarship. (
  • Regardless of the cause, the lack of participation of these groups in clinical trials raises important questions about the quality and ethics of clinical research. (
  • While clinical trials are important, the choice to participate in one is very personal and depends on your unique situation. (
  • Most respondents (79% to 92%) rated their recommendation of a trial as important to their client's willingness to participate. (
  • Physicians have significant influence on medical decisions that are made by their patients [ 16 - 18 ], and communication with the physician during clinical encounters is an important factor in the final decision to participate in clinical trials [ 19 - 21 ]. (
  • So, this is a topic that's really important to me on a personal level. (
  • Clinical trials are an extremely important in finding new ways to treat cancer and help patients live well with their diagnosis. (
  • Clinical trials are extremely important if the treatment of people with dementia is to be improved, as well as for the development of preventative measures and ultimately a cure. (
  • 3 It is important to note that at least 23% of the 467 clinical researches approved by the 11 IRBs paid subjects. (
  • Turn your organization's most important initiatives into its biggest successes with clinical trial insights research. (
  • Clinical trial participation is not a new controversy, but hopefully the prominence of this study by Harvey and colleagues will emphasize how important this topic is. (
  • Participation in clinical research is an important professional obligation for cardiovascular practitioners. (
  • When the trial began, HT was already in common use for the treatment of menopausal symptoms. (
  • More than 1,260 adults who were newly diagnosed with breast, lung, or colorectal cancer were asked to participate in a clinical trial on a new type of chemotherapy before they had made treatment decisions. (
  • At the same time, hundreds of thousands of people have been helped and are alive because other people chose to participate in a trial that resulted in a new, more effective treatment. (
  • The common reason given for not reimbursing patients for their participation in trials is the desire to avoid undue influence on patients' decision-making about treatment choices, as articulated in the U.S. Common Rule for the Protection of Human Subjects," Unger and Fleury wrote. (
  • Clinical and laboratory data from RV144, including CD4+ T-cell and HIV-1 plasma viral load measurements, were linked to RV152 to inform primary and secondary protocol analyses as well as volunteer care and treatment. (
  • Patients who participated in clinical trials were unaware of the particulars of the research (e.g., randomization, treatment arms, etc.) or that the treatment was experimental in nature [ 7 - 9 ], and information presented in the consent form was not always taken into account when making medical decisions [ 10 ]. (
  • Our Clinical Trials Community will provide education and resources to help overcome these challenges and accelerate treatment options toward approval. (
  • An international clinical trial on the effectiveness of a high-precision radiation treatment on certain cancer patients, which included Northern Medical Program (NMP) researcher Dr. Rob Olson, has been published in The Lancet, a world-renowned medical journal based in. (
  • An international clinical trial on the effectiveness of a high-precision radiation treatment on certain cancer patients, which. (
  • Treatment from the PREVENT TB Trial in the United States and Canada. (
  • Evaluation of the informed consent process of a multicenter tuberculosis treatment trial. (
  • Serum biomarkers of treatment response within a randomized clinical trial for pulmonary tuberculosis. (
  • Treatment for preventing tuberculosis in children and adolescents: A randomized clinical trial of a 3-month, 12-dose regimen of a combination of rifapentine and isoniazid. (
  • What is the most reliable solid culture medium for tuberculosis treatment trials? (
  • This is the N-MOmentum study, this is a clinical research study in NMO that if successful and approved will give the NMO community and physicians that treat this rare disease a new approved treatment alternative. (
  • Clinical trials may also compare a new treatment to a treatment that is already available. (
  • Clinical trials are required to determine whether an experimental medicine, treatment or device is safe and effective. (
  • 6 The UK National Institute for Health and Clinical Excellence concluded that programmes incorporating behavioural treatment alongside physical activity and diet were effective, particularly if parents were given the responsibility for behaviour change. (
  • With the support of the state of Texas and New Mexico, a solid infrastructure has been developed to support laboratory-based and clinical research focused on improving the treatment and quality of life for patients with IBC. (
  • Addressing patients and caregivers, she encouraged patients to be fully immersed in their care as equal partners with their oncologists, starting with reflection on personal priorities and including being well informed about their treatment options (clinical trials and standard of care). (
  • The department of Radiation Oncology is involved in clinical and translational research, aimed at the improvement of cancer treatment and quality of life. (
  • Topics within the area of long-term adverse effects are proton beam irradiation, reduction of late effects and rehabilitation for gynaecological tumours, organ sparing treatment in rectal cancers, and palliative medicine and radiotherapy. (
  • The PORTEC trials have defined the role of radiation therapy in endometrial cancer and have had major impact on international treatment guidelines. (
  • The ongoing 4th PORTEC trial is the first in the field of integrated clinical and molecular risk profiling determining the indication for adjuvant treatment. (
  • The bone metastasis trial has made '1x8 Gy' the treatment of choice. (
  • These methods and practices are being honed within the context of pragmatic clinical trials, which measure the effectiveness of treatment options in real-world settings. (
  • Definitive evaluation of its clinical effectiveness by randomised controlled trial is now required. (
  • The two European Federation of Pharmaceutical Industries and Associations (EFPIA) project sponsors, MedImmune and AiCuris, will provide all required study‐related expertise in clinical development of monoclonal antibodies and antibiotics with MEDI3902 and AIC499 plus BLI as Investigational Medicinal Products (IMPs), respectively. (
  • But the FDA relies on the data from these trials to determine whether medical products are safe and effective. (
  • To make sure that the FDA has a full picture of the risk or benefit of a medical product, patients enrolled in a trial should be representative of the types of patients who are likely to use the medical product if it is approved or cleared by the FDA. (
  • Even as the U.S. population becomes steadily more diverse, minorities and women remain underrepresented in clinical trials to develop new drugs and medical devices. (
  • In the United States, a clinical trial must have an IRB if it is studying a drug, biological product, or medical device that the Food and Drug Administration (FDA) regulates, or it is funded or carried out by the federal government. (
  • Randomized clinical trials are a critical means of advancing medical knowledge. (
  • Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields. (
  • Did my participation lead to knowledge that will help others dealing with an illness or medical condition? (
  • Following a position as an Associate Professor of Medicine and Attending Physician at UPCH University Hospital, he joined Merck & Co., Inc (Merck, Sharp & Dohme) in 1984 first as a Medical Director and eventually as the vice president of Clinical Research Operations - Global Trial Management. (
  • Clinical trials play a significant role in medical research and, without them, innovative discoveries and breakthroughs wouldn't make it to the patients who need them. (
  • For the 2013 calendar year, medical professionals are recruiting sickle cell patients for more than 100 clinical trials. (
  • This topic dovetailed into presentations on disease management through food and medical nutrition. (
  • These legal exemptions ought to be overturned and secular clinical ethicists ought to continue recommending the override of religiously motivated medical refusals for children. (
  • At NIH in 1998, Pinn briefed Sarah, Duchess of York, on medical research topics and major health messages regarding women. (
  • After the RV144 trial, a number of correlates of protection were described, that is, immune responses that were associated with protection against infection in this trial and based primarily on the induction of non-neutralizing antibodies. (
  • Clinical trials produce the best data available for health care decisionmaking. (
  • But despite free drugs and follow-up care, the social and financial costs of clinical trial participation often are the deciding factor for low-income patients - the group with the overall lowest participation rate. (
  • Methods and analysis In this pilot randomised controlled trial, 120 people with diabetes will be randomised with equal allocation to receive the intervention or usual clinical care. (
  • NIA communications are directly focused as well on professional audiences in research, clinical care and service delivery, and policy/legislation. (
  • Priorities for future advocacy and clinical care needs were also highlighted. (
  • The Collaboratory supports implementation of clinical trials called "pragmatic clinical trials," which are conducted at the site of care with healthcare delivery organizations actively participating in the research. (
  • This program is providing a framework of implementation methods and best practices to enable participation by many health care systems. (
  • Clinical care is based at the UAB Women and Infant's Center as well as the Obstetric Complications Clinic. (
  • Additional details on the clinical care provided by UAB Maternal-Fetal Medicine can be found on the UAB Medicine website. (
  • This entry was posted in Clinical Ethics , Decision making , Education , Ethics , Featured Posts , Global Ethics , Health Care , Pediatrics and tagged Interprofessional collaboration , Interprofessional Conflicts . (
  • And thank you for understanding that The Guthy-Jackson Charitable Foundation does not perform clinical trials nor does it endorse any particular clinical trial design or a drug. (
  • Career advancement, fulfillment of a desire to do good, an opportunity to publish in a peer-reviewed journal, fame, invitations to present at national and international meetings, future success in obtaining grant funding for research, prestigious research prizes, professional accolades for obtaining a positive outcome from a particular clinical trial, and a personal sense of worth-all potentially accrue to the physician-investigator. (
  • The national strategy focuses on the fact that all recruitment and participation is local, and that it is a shared responsibility with shared benefits. (