Paraplegia
Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
Spastic Paraplegia, Hereditary
A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)
Spinal Cord Ischemia
Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.
Spinal Cord Injuries
Tuberculosis, Spinal
Paraparesis
Aortic Aneurysm, Thoracic
Quadriplegia
Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or rarely MUSCULAR DISEASES. The locked-in syndrome is characterized by quadriplegia in combination with cranial muscle paralysis. Consciousness is spared and the only retained voluntary motor activity may be limited eye movements. This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts.
Spinal Cord Compression
Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.
Laminectomy
A surgical procedure that entails removing all (laminectomy) or part (laminotomy) of selected vertebral lamina to relieve pressure on the SPINAL CORD and/or SPINAL NERVE ROOTS. Vertebral lamina is the thin flattened posterior wall of vertebral arch that forms the vertebral foramen through which pass the spinal cord and nerve roots.
Hysteria
Myelography
Thoracic Vertebrae
Muscle Spasticity
A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a "free interval") followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
Spinal Cord
Aortography
Pedigree
Blood Vessel Prosthesis Implantation
Aneurysm, Dissecting
Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.
Myelitis, Transverse
Inflammation of a transverse portion of the spinal cord characterized by acute or subacute segmental demyelination or necrosis. The condition may occur sporadically, follow an infection or vaccination, or present as a paraneoplastic syndrome (see also ENCEPHALOMYELITIS, ACUTE DISSEMINATED). Clinical manifestations include motor weakness, sensory loss, and incontinence. (Adams et al., Principles of Neurology, 6th ed, pp1242-6)
Arachnoiditis
Acute or chronic inflammation of the arachnoid membrane of the meninges most often involving the spinal cord or base of the brain. This term generally refers to a persistent inflammatory process characterized by thickening of the ARACHNOID membrane and dural adhesions. Associated conditions include prior surgery, infections, trauma, SUBARACHNOID HEMORRHAGE, and chemical irritation. Clinical features vary with the site of inflammation, but include cranial neuropathies, radiculopathies, and myelopathies. (From Joynt, Clinical Neurology, 1997, Ch48, p25)
Tabes Dorsalis
Parenchymatous NEUROSYPHILIS marked by slowly progressive degeneration of the posterior columns, posterior roots, and ganglia of the spinal cord. The condition tends to present 15 to 20 years after the initial infection and is characterized by lightening-like pains in the lower extremities, URINARY INCONTINENCE; ATAXIA; severely impaired position and vibratory sense, abnormal gait (see GAIT DISORDERS, NEUROLOGIC), OPTIC ATROPHY; Argyll-Robertson pupils, hypotonia, hyperreflexia, and trophic joint degeneration (Charcot's Joint; see ARTHROPATHY, NEUROGENIC). (From Adams et al., Principles of Neurology, 6th ed, p726)
Paraparesis, Spastic
Cinnarizine
Aorta, Thoracic
Hematoma, Epidural, Spinal
Adaptor Protein Complex 4
Aortic Rupture
Genes, Dominant
Blood Vessel Prosthesis
Heart Bypass, Left
Decompression, Surgical
Cerebrospinal Fluid Pressure
Cellulose, Oxidized
Aortic Aneurysm, Abdominal
Adenosine Triphosphatases
Kyphosis
Reflex, Babinski
A reflex found in normal infants consisting of dorsiflexion of the HALLUX and abduction of the other TOES in response to cutaneous stimulation of the plantar surface of the FOOT. In adults, it is used as a diagnostic criterion, and if present is a NEUROLOGIC MANIFESTATION of dysfunction in the CENTRAL NERVOUS SYSTEM.
Electronic Mail
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Editorial Policies
Authorship
Postal Service
Energy cost of propulsion in standard and ultralight wheelchairs in people with spinal cord injuries. (1/1047)
BACKGROUND AND PURPOSE: Wheelchair- and subject-related factors influence the efficiency of wheelchair propulsion. The purpose of this study was to compare wheelchair propulsion in ultralight and standard wheelchairs in people with different levels of spinal cord injury. SUBJECTS: Seventy-four subjects (mean age=26.2 years, SD=7.14, range=17-50) with spinal cord injury resulting in motor loss (30 with tetraplegia and 44 with paraplegia) were studied. METHOD: Each subject propelled standard and ultralight wheelchairs around an outdoor track at self-selected speeds, while data were collected at 4 predetermined intervals. Speed, distance traveled, and oxygen cost (VO2 mL/kg/m) were compared by wheelchair, group, and over time, using a Bonferroni correction. RESULTS: In the ultralight wheelchair, speed and distance traveled were greater for both subjects with paraplegia and subjects with tetraplegia, whereas VO2 was less only for subjects with paraplegia. Subjects with paraplegia propelled faster and farther than did subjects with tetraplegia. CONCLUSION AND DISCUSSION: The ultralight wheelchair improved the efficiency of propulsion in the tested subjects. Subjects with tetraplegia, especially at the C6 level, are limited in their ability to propel a wheelchair. (+info)Heart rate during exercise with leg vascular occlusion in spinal cord-injured humans. (2/1047)
Feed-forward and feedback mechanisms are both important for control of the heart rate response to muscular exercise, but their origin and relative importance remain inadequately understood. To evaluate whether humoral mechanisms are of importance, the heart rate response to electrically induced cycling was studied in participants with spinal cord injury (SCI) and compared with that elicited during volitional cycling in able-bodied persons (C). During voluntary exercise at an oxygen uptake of approximately 1 l/min, heart rate increased from 66 +/- 4 to 86 +/- 4 (SE) beats/min in seven C, and during electrically induced exercise at a similar oxygen uptake in SCI it increased from 73 +/- 3 to 110 +/- 8 beats/min. In contrast, blood pressure increased only in C (from 88 +/- 3 to 99 +/- 4 mmHg), confirming that, during exercise, blood pressure control is dominated by peripheral neural feedback mechanisms. With vascular occlusion of the legs, the exercise-induced increase in heart rate was reduced or even eliminated in the electrically stimulated SCI. For C, heart rate tended to be lower than during exercise with free circulation to the legs. Release of the cuff elevated heart rate only in SCI. These data suggest that humoral feedback is of importance for the heart rate response to exercise and especially so when influence from the central nervous system and peripheral neural feedback from the working muscles are impaired or eliminated during electrically induced exercise in individuals with SCI. (+info)Airway hyperresponsiveness to ultrasonically nebulized distilled water in subjects with tetraplegia. (3/1047)
The majority of otherwise healthy subjects with chronic cervical spinal cord injury (SCI) demonstrate airway hyperresponsiveness to aerosolized methacholine or histamine. The present study was performed to determine whether ultrasonically nebulized distilled water (UNDW) induces airway hyperresponsiveness and to further elucidate potential mechanisms in this population. Fifteen subjects with SCI, nine with tetraplegia (C4-7) and six with paraplegia (T9-L1), were initially exposed to UNDW for 30 s; spirometry was performed immediately and again 2 min after exposure. The challenge continued by progressively increasing exposure time until the forced expiratory volume in 1 s decreased 20% or more from baseline (PD20) or the maximal exposure time was reached. Five subjects responding to UNDW returned for a second challenge 30 min after inhalation of aerosolized ipratropium bromide (2.5 ml of a 0.6% solution). Eight of nine subjects with tetraplegia had significant bronchoconstrictor responses to UNDW (geometric mean PD20 = 7.76 +/- 7.67 ml), whereas none with paraplegia demonstrated a response (geometric mean PD20 = 24 ml). Five of the subjects with tetraplegia who initially responded to distilled water (geometric mean PD20 = 5.99 +/- 4.47 ml) were not responsive after pretreatment with ipratropium bromide (geometric mean PD20 = 24 ml). Findings that subjects with tetraplegia are hyperreactive to UNDW, a physicochemical agent, combined with previous observations of hyperreactivity to methacholine and histamine, suggest that overall airway hyperresponsiveness in these individuals is a nonspecific phenomenon similar to that observed in patients with asthma. The ability of ipratropium bromide to completely block UNDW-induced bronchoconstriction suggests that, in part, airway hyperresponsiveness in subjects with tetraplegia represents unopposed parasympathetic activity. (+info)Anaesthetic management of a woman who became paraplegic at 22 weeks' gestation after a spontaneous spinal cord haemorrhage secondary to a presumed arteriovenous malformation. (4/1047)
A 19-yr-old woman developed a paraplegia with a T10 sensory level at 22 weeks' gestation. The spinal injury was caused by spontaneous bleed of a presumed arteriovenous malformation in the spinal cord. She presented for Caesarean section at term because of the breech position of her fetus. The successful use of a combined spinal epidural-regional anaesthetic is described and the risks of general and regional anaesthesia are discussed. (+info)Occurrence of familial spastic paraplegia in only one of monozygous twins. (5/1047)
Three patients who suffer from spastic paraplegia are described who belong to two generations in one family. One of the patients, who has had symptoms and signs for at least 10 years, has a monozygous twin who is unaffected. Using blood groups and chromosomal polymorphisms, the probability of monozygosity is estimated to be 0.99986. The observation of nonpenetrance in familial spastic paraplegia suggests that environmental factors may be involved in provocation and emphasises the need for careful genetic counselling in this and related diseases. (+info)Neurotoxic effects of 2,5-hexanedione on normal and neurofilament-deficient quail. (6/1047)
The neurotoxic effects of 2,5-hexanedione (2,5-HD) were investigated using neurofilament (NF)-deficient (Quv) Japanese quail in comparison with normal Japanese quail. Both Quv and normal Japanese quail were inoculated intraperitoneally with 350 mg/kg/day 2,5-HD for 6 consecutive wk. The results of 2,5-HD exposure differed substantially between the 2 strains of Japanese quail. The 2,5-HD-exposed normal quail showed leg paralysis about 4 wk after initiation of dosing. Some treated normal quail fell into dysstasia and died of nutritional disturbances. Histologically, 2,5-HD-treated normal quail had NF-rich axonal swellings and degeneration in the distal parts of the peripheral nerves, spinal cord, and cerebellar peduncles. In contrast, 2,5-HD-injected Quv quail showed tonic convulsion, ataxia gait, severe quivering, and excitation about 2-3 days after administration. Some treated Quv birds died immediately after systemic tonic convulsion, probably because of asphyxia. Although all treated Quv quail showed neurologic signs, there were no recognizable 2,5-HD-induced lesions in the nervous system. After about 4-6 wk of dosing, 2,5-HD induced distal axonopathy in normal quail and acute neurotoxicity in Quv quail. (+info)Triplet pregnancy achieved through intracytoplasmic sperm injection with spermatozoa obtained by prostatic massage of a paraplegic patient: case report. (7/1047)
Spinal cord-injured men with ejaculation disorders can have children thanks to assisted reproduction techniques. Spermatozoa from these patients are usually obtained through vibratory stimulation, electroejaculation or by puncturing the seminal duct or the testicle. We present the first published case, as far as we are aware, of spermatozoa obtained through prostatic massage of a paraplegic patient. Penile vibratory stimulation was unsuccessful in this patient. In-vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) with spermatozoa obtained through electroejaculation was performed at another centre but pregnancy was not achieved. Through prostatic massage, we obtained a total semen volume of 6 ml containing a total count of 12.32x10(6) spermatozoa (6.24x10(6) with tails), 8% of which had motility (graded + and ++); and 16% of which had normal morphology. The spermatozoa obtained were then used to perform IVF with ICSI and a triplet pregnancy was achieved. Prostatic massage appears to be an easy, non-traumatic and risk-free method to obtain spermatozoa from paraplegic patients. (+info)Pregnancy of the wife of a complete paraplegic by homologeous insemination after an intrathecal injection of neostigmine. (8/1047)
A case of successful pregnancy following artificial insemination following intrathecal neostigmine injection in the wife of a complete traumatic paraplegic (T7-T8 to T11-T12) is described. (+info)
Acute Paraplegia as a Presentation of Aortic Saddle Embolism
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Paraplegic rats walk and regain feeling after stem cell treatment - Science Bulletin
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Influence of neurological level of injury in bones, muscles, and fat in paraplegia
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Definition for paraplegic
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Delayed GM-CSF treatment stimulates axonal regeneration and functional recovery in paraplegic rats via an increased BDNF...
paraplegia | Difference Between
Painful paraplegia: Definition with Painful paraplegia Pictures and Photos
Septuagenarian dies on Air Peace flight - Punch
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View Tetraplegia Paraplegia A Guide For Physiotherapists 5Th Edition
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Basal ganglia symptoms and Focal seizure and Hyperreflexia and Paraplegia and Sudden onset of foot weakness exacerbated by...
Sudden Onset of Paraplegia: T2 and T3 Collapse with Abscess - Tuberculosis Case: How to Treat the Abscess
Tips and ideas from Kristoffer
Read a Superb Health Sample Essay on «How Paraplegia Affects the Lower Extremities» for Free at MarvelousEssay.org
Face symptoms and Focal seizure and Hyperreflexia and Intermittent tingling sensation in both arms and Paraplegia - Symptom...
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The New Family / 1,000 Families Project: Rocking the Chair with Robert Buren, a Dad Living with Paraplegia - The New Family
Therapy
Paraplegic person, labia is a little puffy on outside, swollen on inner side. What I could do to treat at home? - Doctors...
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Sports Participation by Paraplegics: Overview, History, Commonly Participated Sports
Sanjeevs Latest Blogs: Aug 11, 2011
Paraplegia (in SafetyLit)
Transient paraplegia after stent grafting of a descending thoracic aortic aneurysm treated with cerebrospinal fluid drainage<...
BlackBush Car Auction: California Paraplegia Lawyer, Southern California Paraplegia Attorney
Cerebral paraplegia | definition of cerebral paraplegia by Medical dictionary
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Increased cardiovascular disease risk in Swedish persons with paraplegia: The Stockholm spinal cord injury study<...
Hereditary spastic paraplegia (Version 1.217)
Traumatic Spinal Cord Injury Global Clinical Trials Review, H2, 2014 | news.sys-con.com
Oalib search
The feasibility of a brain-computer interface functional electrical stimulation system for the restoration of overground...
Linkage of pure autosomal recessive familial spastic paraplegia to chromosome 8 markers and evidence of genetic locus...
Hereditary Spastic Paraplegia
Summary Report | CureHunter
Alteration of ornithine metabolism leads to dominant and recessive hereditary spastic paraplegia<...
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hereditary spastic paraplegia
Genetic and phenotypic characterization of complex hereditary spastic paraplegia
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Hereditary spastic paraplegia
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NHS website
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Paraplegia / Quadriplegia
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T52 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Consejo Superior de Deportes (2011). ...
Spinal cord injury
Paraplegia occurs when the legs are affected by the spinal cord damage (in thoracic, lumbar, or sacral injuries), and ... Thoracic spinal injuries result in paraplegia, but function of the hands, arms, and neck are not affected. One condition that ... Long term outcomes also range widely, from full recovery to permanent tetraplegia (also called quadriplegia) or paraplegia. ... Paraplegia. 29 (9): 573-81. doi:10.1038/sc.1991.85. PMID 1787981. Field-Fote 2009, p. 8. Yakura, J.S. (Dec 22, 1996). "Recovery ...
Amputee sports classification
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Miller, Mark D.; Thompson, Stephen R. ( ...
S10 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Vanlandewijck, Yves C.; Thompson, Walter ...
Joan Scruton
Harris, Phillip (May 1994). "Miss Joan Scruton MBE". Paraplegia. 32 (5): 362-63. doi:10.1038/sc.1994.62. Hums, Mary (2010). " ...
Joë Bousquet
Ohry A, Ohry-Kossoy K. Joë Bousquet: paraplegia as a poet's plight and challenge. Paraplegia. 1988 Aug;26(4):273-7. Media ...
F3 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. "UCI Cycling Regulations - Para cycling ...
T44 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Zettler, P. Is It Cheating to Use ...
S1 (classification)
Paraplegia. 23. Retrieved July 25, 2016. Consejo Superior de Deportes (2011). Deportistas sin Adjectivos (PDF) (in Spanish). ...
A3 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Dyer, B. An Insight into the Acceptable ...
T42 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Nolan, Lee; Patritti, Benjamin L.; Stana ...
S3 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Vanlandewijck, Yves C.; Thompson, Walter ... Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Consejo Superior de Deportes (2011). ... Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Consejo Superior de Deportes (2011). ... Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Consejo Superior de Deportes (2011). ...
A1 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Hassani, Hossein; Ghodsi, Mansi; Shadi, ...
F7 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. IWAS (20 March 2011). "IWF RULES FOR ...
Kookal Ramunni Krishnan
Paraplegia. 1986;24:138-147. Quality of life in patients with spinal cord injury-basic issues, assessment, and recommendations ...
A7 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. "Guide to the Paralympic Games - Appendix ...
Anterior spinal artery syndrome
Foo, D; Rossier, AB (Feb 1983). "Anterior spinal artery syndrome and its natural history". Paraplegia. 21 (1): 1-10. doi: ... "Interventions for reversing delayed-onset postoperative paraplegia after thoracic aortic reconstruction". The Annals of ...
Giles Brindley
Sacral anterior root stimulators for bladder control in paraplegia. Paraplegia. 1982 Dec;20(6):365-81. Holland, Owen; Husbands ...
Pulmonary fibrosis
Paraplegia. 27 (4): 278-83. doi:10.1038/sc.1989.42. PMID 2780083. eMedicine Specialties > Pulmonology > Interstitial Lung ...
T45 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. "PARALYMPIC TRACK & FIELD: Officials ...
T53 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. "PARALYMPIC TRACK & FIELD: Officials ... E.g. high level paraplegia." The International Paralympic Committee defined this class in 2011 as "These athletes will have ...
F5 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. "Applying for Adaptive Classification" ( ...
Boosting (doping)
Paraplegia. International Medical Society of Paraplegia. 32 (5): 289-291. doi:10.1038/sc.1994.50. PMID 8058344. Retrieved 23 ...
Myelitis
Baum J, Solomon M, Alba A (1981). "Sarcoidosis as a cause of transverse myelitis: case report". Paraplegia. 19 (3): 167-9. doi: ...
F6 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Tim-Taek, Oh; Osborough, Conor; Burkett, ...
A9 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Vanlandewijck, Yves C.; Thompson, Walter ... Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Labanowich, Stan; Thiboutot, Armand (2011 ...
F55 (classification)
Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. Miller, Mark D.; Thompson, Stephen R. ( ... Paraplegia. International Medical Society of Paraplegia. 23. Retrieved July 25, 2016. "PARALYMPIC TRACK & FIELD: Officials ...
Ludwig Guttmann
Bedbrook, G. (1982). "International Medical Society of Paraplegia first Ludwig Guttmann Memorial Lecture". Paraplegia. 20 (1): ... Guttmann became the first editor of the journal, Paraplegia (now named Spinal Cord).[18] He suffered a heart attack in October ... Ross, J. C.; Harris, P. (1980). "Tribute to Sir Ludwig Guttmann". Paraplegia. 18 (3): 153-156. doi:10.1038/sc.1980.27. PMID ... In the same year, he became the inaugural President of the International Medical Society of Paraplegia (now the International ...
ICD-10 Chapter VI: Diseases of the nervous system
G82) Paraplegia and tetraplegia *(G82.0) Flaccid paraplegia. *(G82.1) Spastic paraplegia. *(G82.2) Paraplegia, unspecified * ...
Coffin-Lowry syndrome
Paraplegia or partial paralysis. Physical therapy Delayed speech. Limited vocabulary. Most common. Least common. Speech therapy ... progressive loss of muscle strength and tone leading to paraplegia or partial paralysis. Affected individuals are at elevated ...
Paraplegia -- Britannica Online Encyclopedia
Tuberculous paraplegia. | The BMJ
Tuberculous paraplegia. | The BMJ
Hereditary Spastic Paraplegia | Encyclopedia.com
Source for information on Hereditary Spastic Paraplegia: Gale Encyclopedia of Genetic Disorders dictionary. ... Hereditary spastic paraplegiaDefinitionHereditary spastic paraplegia (HSP) is not a single entity, but a group of clinically ... Hereditary spastic paraplegia. Definition. Hereditary spastic paraplegia (HSP) is not a single entity, but a group of ... Hereditary Spastic Paraplegia. Updated About encyclopedia.com content Print Article Share Article ...
What Causes Paraplegia?
Most commonly, paraplegia is the result of accidents, which occur most often in the young adult male population, between 15 and ... Paraplegia has a host of causes, ranging from the local to the cerebral. ... Paraplegia has a host of causes, ranging from the local to the cerebral. Most commonly, paraplegia is the result of accidents, ... The causes of paraplegia may be classified under the following headings:. Trauma to the spinal cord or brain. *Accidents may ...
Hereditary spastic paraplegia
... (HSP) refers to a group of familial diseases that are characterized by progressive degeneration ... Classification of the hereditary ataxias and paraplegias. Lancet 1983; 1:1151.. *Fink JK. Hereditary spastic paraplegia ... X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene. Nat Genet ... Hereditary spastic paraplegia. Authors. Puneet Opal, MD, PhD. Puneet Opal, MD, PhD ...
Spastic paraplegia type 7: MedlinePlus Genetics
... is one of more than 80 genetic disorders known as hereditary spastic paraplegias. Explore symptoms, inheritance, genetics of ... Spastic paraplegia type 7 (also called SPG7) is one of more than 80 genetic disorders known as hereditary spastic paraplegias. ... Spastic paraplegia type 7 likely accounts for only a small percentage of all spastic paraplegia cases. ... Like all hereditary spastic paraplegias, spastic paraplegia type 7 involves spasticity of the leg muscles and some muscle ...
Spastic paraplegia type 3A: MedlinePlus Genetics
Spastic paraplegia type 3A is one of a group of genetic disorders known as hereditary spastic paraplegias. Explore symptoms, ... Spastic paraplegia type 3A is one of a group of genetic disorders known as hereditary spastic paraplegias. These disorders are ... Spastic paraplegia type 3A belongs to a subgroup of hereditary spastic paraplegias known as autosomal dominant hereditary ... Spastic paraplegia type 3A accounts for 10 to 15 percent of all autosomal dominant hereditary spastic paraplegia cases. ...
What is paraplegia? Definition, causes, and treatment
... learn about the definition of paraplegia, as well as the symptoms, causes, diagnosis, and treatment options associated with it. ... Paraplegia is a form of paralysis that mostly affects the movement of the lower body. People with paraplegia may be unable to ... Some chronic conditions can also lead to paraplegia. Conditions that might cause paraplegia include: *tumors or lesions of the ... Paraplegia refers to paralysis that occurs in the lower half of the body. It can be a result of an accident or a chronic ...
Paraplegia vs. quadriplegia: Definitions, causes, and more
Paraplegia and quadriplegia are forms of paralysis that can result from health issues or physical trauma. Here, learn about the ... Challenges of paraplegia. A person with paraplegia may have limited mobility and sensation in the legs. However, they retain ... Paraplegia can affect the sensory nerves, causing numbness or hypersensitivity. As a result, a person with paraplegia may not ... Paraplegia and quadriplegia are forms of paralysis, which is the partial or complete loss of movement in one or more parts of ...
Paraplegia News, Research - Page 6
Paraplegia - Wikipedia
Spastic paraplegia is a form of paraplegia defined by spasticity of the affected muscles, rather than flaccid paralysis. The ... Paraplegia is an impairment in motor or sensory function of the lower extremities. The word comes from Ionic Greek (παραπληγίη ... Individuals with paraplegia can range in their level of disability, requiring treatments to vary from case to case. ... The area of the spinal canal that is affected in paraplegia is either the thoracic, lumbar, or sacral regions. If four limbs ...
Orthopaedic Surgery of the Limbs in Paraplegia | SpringerLink
Acute Paraplegia due to Thoracic Hematomyelia
... Aykut Akpınar,1 Bahattin Celik,2 Ihsan Canbek,3 and Ergun Karavelioğlu3 ... He presented to an outside hospital with paraplegia, and then he was transferred to a tertiary center for further management. ... On admission, neurological examination of his motor power was reduced (0/5) in both lower extremities (paraplegia), tendon ... idiopathic spontaneous hematomyelia of a previously healthy 80-year-old male with a sudden onset of back pain and paraplegia. ...
Shop by Condition for Paraplegia
Spastic paraplegia 81, autosomal recessive
Hereditary spastic paraplegia - Wikipedia
"Hereditary spastic paraplegia". nhs.uk. 2017-10-18. Retrieved 2018-01-28. Fink JK (2003). "The Hereditary Spastic Paraplegias ... GeneReviews/NCBI/NIH/UW entry on Spastic Paraplegia 3A GeneReviews/NCBI/NIH/UW entry on Hereditary Spastic Paraplegia Overview ... Hereditary spastic paraplegia (HSP) is a group of inherited diseases whose main feature is a progressive gait disorder. The ... In the United States, Hereditary Spastic Paraplegia is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the ...
Paraplegia (in SafetyLit)
Paraplegia - Spinal Paralysis
Paraplegia indicates some disorder of the spinal cord, and consists of paralysis of the posterior half (more or less) of the ... Paraplegia - Spinal Paralysis. Paraplegia indicates some disorder of the spinal cord, and consists of paralysis of the ... Paraplegia in the horse is most commonly the result of injury inflicted on the dorsal or lumbar portion of the cord or its ... Paraplegia in the horse, save when arising out of reflex causes, offers very little encouragement to treatment. Injury to the ...
Paraplegia dolorosa - definition of paraplegia dolorosa by The Free Dictionary
paraplegia dolorosa synonyms, paraplegia dolorosa pronunciation, paraplegia dolorosa translation, English dictionary definition ... of paraplegia dolorosa. n. Complete paralysis of the lower half of the body including both legs, usually caused by damage to ... paraplegia. [ˌpærəˈpliːdʒə] n → paraplegia. par·a·ple·gi·a n. paraplejía, parálisis de la parte inferior del tronco y de las ... paraplegia. (redirected from paraplegia dolorosa). Also found in: Thesaurus, Medical, Encyclopedia. par·a·ple·gia. (păr′ə-plē′ ...
Spastic paraplegia 4, autosomal dominant (Concept Id: C1866855)
- MedGen - NCBI
Spastic paraplegia 4 (SPG4; also known as SPAST-associated HSP) is characterized by insidiously progressive bilateral lower- ... Spastic paraplegia type 4 is a pure hereditary spastic paraplegia.Like all hereditary spastic paraplegias, spastic paraplegia ... Familial spastic paraplegia autosomal dominant 2; Spastic Paraplegia 4; SPG4. Modes of inheritance:. Autosomal dominant ... Spastic paraplegia type 4 is part of a group of genetic disorders known as hereditary spastic paraplegias. These disorders are ...
Hereditary Spastic Paraplegia Clinical Presentation: History, Physical Examination
Hereditary spastic paraplegia (HSP) is not a single disease entity; it is a group of clinically and genetically diverse ... Hereditary spastic paraplegia: advances in genetic research. Hereditary Spastic Paraplegia Working Group. Neurology. 1996 Jun. ... encoded search term (Hereditary Spastic Paraplegia) and Hereditary Spastic Paraplegia What to Read Next on Medscape ... Hereditary Spastic Paraplegia Clinical Presentation. Updated: Jan 14, 2019 * Author: Nam-Jong Paik, MD, PhD; Chief Editor: ...
New exercise device design for people with paraplegia | EurekAlert! Science News
New exercise device design for people with paraplegia Retrofitted rowing machines allow people with paraplegia to exercise ... allowing people with para-plegia to exer-cise without the aid of a trainer. The Capstone group recently filed... view more ... was that some two dozen patients living with a med-ical con-di-tion known as spastic para-plegia lacked suf-fi-cient motor con- ... allowing people with para-plegia to exer-cise without the aid of a trainer. ...
Spastic paraplegia 16 - NORD (National Organization for Rare Disorders)
Virgin Money Giving | The Hereditary Spastic Paraplegia Support Group
Acute Paraplegia as a Presentation of Aortic Saddle Embolism
To describe the occurrence and possible mechanism for aortic saddle embolism as a rare cause of acute paraplegia.,i, Case ... of a 46-year-old female who presented with the sudden onset of nontraumatic low back pain with rapidly progressive paraplegia ... i,Background,/i,. Acute onset paraplegia has a myriad of causes most often of a nonvascular origin. Vascular etiologies are ... Acute Paraplegia as a Presentation of Aortic Saddle Embolism. Lisandro Irizarry. ,1 Anton Wray. ,1 and Kim Guishard1. 1 ...
What is Hereditary Spastic Paraplegia? (with pictures)
Hereditary spastic paraplegia is a condition in which a person experiences a gradual but continuous development of weakness and ... In hereditary spastic paraplegia, there is often a gradual deterioration in the nerves that control the muscles of the legs. ... Hereditary spastic paraplegia (HSP), also referred to as Strumpell-Lorrain disease, familial spastic paraparesis, and spastic ... In uncomplicated hereditary paraplegia, patients usually experience mostly muscle weakness and stiffness in the legs. At the ...
Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms. - PubMed - NCBI
Hereditary spastic paraplegia (HSP) is a syndrome designation describing inherited disorders in which lower extremity weakness ... Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms.. Fink JK1. ... Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms. Acta Neuropathol. ;126(3):307-328 ... MalaCards for spastic paraplegia 39 - The Weizmann Institute of Science GeneCards and MalaCards databases ...
Hereditary-Spastic-Paraplegia-Information-Page | National Institute of Neurological Disorders and Stroke
The NINDS supports research on genetic disorders such as HSP. More than 30 genes that are responsible for several forms of HSP have been identified, and many more will likely be identified in the future. These genes generally encode proteins that normally help maintain the function of axons in the spinal cord. Understanding how mutations of these genes cause HSP should lead to ways to prevent, treat, and cure HSP.. Information from the National Library of Medicines MedlinePlus ...
Hereditary Spastic Paraplegia Workup: Approach Considerations, Electrophysiologic Studies, Histologic Findings
Hereditary spastic paraplegia (HSP) is not a single disease entity; it is a group of clinically and genetically diverse ... encoded search term (Hereditary Spastic Paraplegia) and Hereditary Spastic Paraplegia What to Read Next on Medscape. Related ... Hereditary spastic paraplegia: advances in genetic research. Hereditary Spastic Paraplegia Working Group. Neurology. 1996 Jun. ... Hereditary Spastic Paraplegia Workup. Updated: Jan 14, 2019 * Author: Nam-Jong Paik, MD, PhD; Chief Editor: Stephen Kishner, MD ...
Result in paraplegiaIncomplete paraplegiaSpinal cord iAutosomal dominantThin corpus callosumAcute ParaplegiaDifference Between Paraplegia and QuadriplegiaDefinitionPeople with paraplegia to exercisePatients with hereditary spastic paDifferences between paraplegia and quadriplegiaSymptomsSpasticityParaparesisGeneticsInjury resulting inCommon cause of paraplegiaFamilial spastic paraplegiaKnown as hereditary spasticSpastic Paraplegia FoundationGenesLimbsLead to paraplegiaIndividuals with ParaplegiaQuadriplegia and paraplegiaPure hereditary2017SensorySudden onsetCause paraplegiaCauses ParaplegiaChronic paraplegiaComplete paraplegiaNeurologyRefersOnsetEtiologyAtaxiasParalysis of the legsMutationsClinicalDisordersHSPsTreatmentsDiseaseGroup of inherited diseasesGeneWeaknessNeurological
Result in paraplegia3
- If the survivor has sustained an injury that is below the first thoracic spinal nerve, this will result in paraplegia, the loss of sensation or movement-to some degree-in the legs, bowel, bladder, and sexual region. (brainandspinalcord.org)
- When an accident occurs, it is the trauma that can result in paraplegia. (pfaffgill.com)
- Although successful treatment cures the disease, the risky procedures can result in paraplegia from spinal cord ischaemia or even death, particularly for aneurysms extending from the thoracic to the abdominal aorta and thus involving many segmental arteries to the spinal cord, i.e. thoracoabdominal aortic aneurysms of Crawford type II. (europa.eu)
Incomplete paraplegia4
- Some people experience incomplete paraplegia. (medicalnewstoday.com)
- In incomplete paraplegia the hind-quarters roll from side to side, the animal crosses his hind-limbs, sometimes trails the toes, or knuckles over with the fetlock joints. (chestofbooks.com)
- Complete paraplegia is when a person loses both feeling and movement below his or her injury, while incomplete paraplegia is when a person maintains some movement or feeling below the injury. (bdjinjurylawyers.com)
- These cases frequently result in dramatically higher treatment, rehabilitation, and accommodation costs, but even cases of incomplete paraplegia can result in millions of dollars' worth of bills of your lifetime. (njlawyers.com)
Spinal cord i10
- Spinal stimulation helps four patients with paraplegia regain voluntary movement - Groundbreaking results bring new hope for those with spinal cord injury - NIH study. (disabled-world.com)
- The researchers are investigating the ability of persons with paraplegia to learn to stand and walk with the ReWalk-I and the effects of being upright and walking on several of these secondary medical consequences of spinal cord injury. (clinicaltrials.gov)
- Quadriplegia and paraplegia are two types of spinal cord injuries that differ by the degree of paralysis and the location of the spinal cord injury site. (oshmanlaw.com)
- Paraplegia is a type of spinal cord injury in which paralysis affects the spinal cord at the thoracic, lumbar, or sacral regions (corresponding to the mid and lower areas of the back) resulting in complete or incomplete loss of feeling and/or function to the lower limbs and part of the trunk. (oshmanlaw.com)
- Symptoms of quadriplegia and paraplegia depend on the exact site and severity of the spinal cord injury. (oshmanlaw.com)
- When a spinal cord injury is suspected following an accident, it is vital that emergency personnel take great care in moving the patient, as even slight shifting can exacerbate the damage and increase the risk of permanent quadriplegia or paraplegia. (oshmanlaw.com)
- People with spinal cord injury (SCI) paraplegia who receive exercise treatment for shoulder pain experience significant increases in social participation and improvements in quality of life (QOL), say authors of an article in The Journal of Spinal Cord Medicine . (apta.org)
- According to the University of Alabama National Spinal Cord Injury Statistical Center, nearly 8,000 individuals suffer an injury resulting in paraplegia each year. (pfaffgill.com)
- Paraplegia is a spinal cord injury that prevents movement and sensation in the legs, lower stomach region and/or lower back region. (pfaffgill.com)
- If you or a loved one has suffered a serious spinal cord injury that resulted in paraplegia, contact Pfaff, Gill & Ports, Ltd., for help today. (pfaffgill.com)
Autosomal dominant4
- Hereditary spastic paraplegias include autosomal dominant, autosomal recessive, and X-linked forms. (uptodate.com)
- Spastic paraplegia type 3A belongs to a subgroup of hereditary spastic paraplegias known as autosomal dominant hereditary spastic paraplegia, which has an estimated prevalence of 2 to 9 per 100,000 individuals. (medlineplus.gov)
- Spastic paraplegia type 3A accounts for 10 to 15 percent of all autosomal dominant hereditary spastic paraplegia cases. (medlineplus.gov)
- Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. (curehunter.com)
Thin corpus callosum2
- A study by Pascual et al indicated that the appearance of the ears-of-the-lynx sign on fluid-attenuated inversion recovery (FLAIR) MRI-a sign consisting of changes to the periventricular white matter in the frontal horn region that resemble hair tufts on lynx ears-is highly specific for the presence of "the most common genetic subtypes of hereditary spastic paraplegia with a thin corpus callosum. (medscape.com)
- SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum. (natureasia.com)
Acute Paraplegia4
- To describe the occurrence and possible mechanism for aortic saddle embolism as a rare cause of acute paraplegia. (hindawi.com)
- An atypical case of acute paraplegia following a fall, on the ground of a thoracolumbar schwannoma, without intratumoral hemorrhage, in a previously asymptomatic patient is reported. (spandidos-publications.com)
- A 58‑year‑old male patient presented with acute paraplegia, and urinary and bowel incontinence, following a fall. (spandidos-publications.com)
- Lee ST and Lui TN: Acute paraplegia resulting from haemorrhage into a spinal neurofibroma. (spandidos-publications.com)
Difference Between Paraplegia and Quadriplegia1
- what's the main difference between paraplegia and quadriplegia, if any? (healthtap.com)
Definition1
- The definition of paraplegia is fairly wide, and paraplegics can experience anything from a slight impairment of leg movement to complete loss of leg movement all the way up to the chest. (brainandspinalcord.org)
People with paraplegia to exercise1
- Engineers have developed a new type of microchip muscle stimulator implant that will enable people with paraplegia to exercise their paralysed leg muscles. (scienceblog.com)
Patients with hereditary spastic pa2
- Mutational spectrum of the SPG4 (SPAST) and SPG3A (ATL1) genes in Spanish patients with hereditary spastic paraplegia. (medlineplus.gov)
- Treatment of patients with hereditary spastic paraplegia often involves regular physical therapy . (wisegeek.com)
Differences between paraplegia and quadriplegia1
- What are the differences between paraplegia and quadriplegia? (medicalnewstoday.com)
Symptoms10
- Signs and symptoms of hereditary spastic paraplegias are characterized by progressive muscle stiffness (spasticity) in the legs and difficulty walking. (medlineplus.gov)
- Nonfunctional m-AAA proteases cause a build-up of unusable proteins in the mitochondria of nerve cells, which can result in swelling of the cell, reduced cell signaling, and impaired cell movement, leading to the major signs and symptoms of spastic paraplegia type 7. (medlineplus.gov)
- This impaired nerve function leads to the signs and symptoms of spastic paraplegia type 3A. (medlineplus.gov)
- However, long-term treatment options exist to help reduce symptoms and complications in people with paraplegia. (medicalnewstoday.com)
- There are many symptoms that can occur in paraplegia. (medicalnewstoday.com)
- To diagnose paraplegia, a doctor will assess the person's symptoms and medical history. (medicalnewstoday.com)
- Patients with complicated hereditary spastic paraplegia often experience similar symptoms in the legs, but they usually have additional nervous system problems. (wisegeek.com)
- Hereditary spastic paraplegia (HSP) is a syndrome designation describing inherited disorders in which lower extremity weakness and spasticity are the predominant symptoms. (nih.gov)
- What symptoms can a person expect to result from paraplegia? (bdjinjurylawyers.com)
- What are the symptoms of quadriplegia and paraplegia? (oshmanlaw.com)
Spasticity13
- Spastic paraplegia is a form of paraplegia defined by spasticity of the affected muscles, rather than flaccid paralysis. (wikipedia.org)
- When the only manifested symptom is progressive spasticity, HSP is also known as pure hereditary spastic paraplegia. (encyclopedia.com)
- Like all hereditary spastic paraplegias, spastic paraplegia type 7 involves spasticity of the leg muscles and some muscle weakness. (medlineplus.gov)
- These disorders are characterized by muscle stiffness (spasticity) and weakness in the lower limbs (paraplegia). (medlineplus.gov)
- Some treatments for paraplegia, such as muscle relaxant medications and physical therapy , can help with spasticity. (medicalnewstoday.com)
- A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. (uniprot.org)
- As previously mentioned, hereditary spastic paraplegia (HSP) is not a single disease entity but a group of clinically and genetically diverse disorders that cause progressive and generally severe lower extremity weakness and spasticity. (medscape.com)
- Spastic paraplegia of unknown origin is a movement disorder in which there is progressive weakness and spasticity (stiffness) of the legs. (patientslikeme.com)
- Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative disorders marked by lower-limb spasticity (stiffness) and weakness, leading to progressive difficulty walking. (sdbonline.org)
- The human PAPLA1 phospholipase family is associated with hereditary spastic paraplegia (HSP) , a neurodegenerative syndrome characterized by progressive spasticity and weakness of the lower limbs. (sdbonline.org)
- Hereditary spastic paraplegia, or HSP, refers to a clinical designation for neurological syndromes characterized by bilateral lower limb spasticity, or stiffness and weakness, which are caused by gene mutation and therefore they are inherited. (hstalks.com)
- Hereditary Spastic Paraplegia (HSP) is a heterogeneous group of inherited neurodegenerative disorders with weakness and spasticity of the lower limbs as its main clinical feature. (omicsonline.org)
- Hereditary spastic paraplegia (HSP), which is also known as Strumpell-Lorraine disease, is a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and weakness of the lower extremities [ 1 , 2 , 3 ]. (mdpi.com)
Paraparesis10
- HSP is also known as hereditary spastic paraparesis, familial spastic paraplegia, French settlement disease, Strumpell disease, or Strumpell-Lorrain disease. (wikipedia.org)
- People sometimes use the term "paraplegia" interchangeably with "paraparesis," which is partial paralysis in the lower body due to muscle weakness and stiffness. (medicalnewstoday.com)
- Hereditary spastic paraplegia (HSP), also referred to as Strumpell-Lorrain disease, familial spastic paraparesis , and spastic paraplegia, belongs to a group of rare genetic disorders that affect the nervous system. (wisegeek.com)
- Spastic Paraplegia-Paraparesis. (nih.gov)
- During a 16-year period 672 patients were admitted to the Columbia Presbyterian Medical Center with spastic paraplegia-paraparesis (SPP) as a prominent finding. (nih.gov)
- AbstractHereditary spastic paraplegias (HSP) are a group of rare neurodegenerative diseases characterized by progressive spastic paraparesis.UBAP1 was recently found to induce a rare type of HSP (SPG80). (medworm.com)
- SI}} ==Overview== '''Hereditary spastic paraplegia''' (HSP), also called '''familial spastic paraparesis''' (FSP), refers to a group of inherited disorders that are characterized by progressive weakness and stiffness of the legs. (wikidoc.org)
- Hereditary spastic paraplegia (HSP), also called hereditary spastic paraparesis, familial spastic paralysis and Strümpell-Lorrain syndrome was first reported in 1876 by Seeligmüller, followed by reports by Strumpell and Lorraine. (omicsonline.org)
- Neurological dysfunction resulting from transient spinal cord ischemia may be clinically expressed as paraparesis, fully-developed spastic paraplegia, or flaccid paraplegia. (ca.gov)
- Whereas cases presenting with paraparesis have been treated with either surgery or radiotherapy with equal frequency and efficacy, almost all reported cases with paraplegia have been treated with surgery with or without radiation therapy. (haematologica.org)
Genetics2
- Group for the Study of the Genetics of Spastic Paraplegia. (medlineplus.gov)
- Today I'm going to talk about the genetics of hereditary spastic paraplegia. (hstalks.com)
Injury resulting in1
- The chance of injury resulting in paraplegia may be reduced by paying careful attention to environmental factors. (doctors-hospital.net)
Common cause of paraplegia2
- Injury to the nervous system is the most common cause of paraplegia. (doctors-hospital.net)
- Studies show the most common cause of paraplegia is motor vehicle accidents, followed by violent acts, falls and sports injuries. (pfaffgill.com)
Familial spastic paraplegia1
- HSP, also called familial spastic paraplegia, was initially referred to as Strumpell-Lorrain disease, a name given for the two physicians who in the late 19th century independently described key features of spastic paraplegia. (uptodate.com)
Known as hereditary spastic3
- Spastic paraplegia type 7 (also called SPG7) is one of more than 80 genetic disorders known as hereditary spastic paraplegias. (medlineplus.gov)
- Spastic paraplegia type 3A is one of a group of genetic disorders known as hereditary spastic paraplegias. (medlineplus.gov)
- Spastic paraplegia type 4 is part of a group of genetic disorders known as hereditary spastic paraplegias. (nih.gov)
Spastic Paraplegia Foundation3
- The Spastic Paraplegia Foundation offers free tools and resources to help you find the answers you need. (sp-foundation.org)
- The Spastic Paraplegia Foundation, Inc. (SPF) is the only organization in the Americas dedicated to finding a cure for two rare diseases, Hereditary Spastic Paraplegia (HSP) and Primary Lateral Sclerosis (PLS). (sp-foundation.org)
- Currently, the Spastic Paraplegia Foundation Board consists of 5 office holders and 9 members that include doctors, nurses and individuals living with HSP and PLS. (sp-foundation.org)
Genes4
- These genes are generically known as spastic paraplegia gene, or SPG. (encyclopedia.com)
- HSP is linked to mutations in several loci known collectively as the spastic paraplegia genes (SPGs). (jci.org)
- Presents a current understanding of the normal and pathological functioning of the genes responsible for ataxias and spastic paraplegias. (elsevier.com)
- Within many multiplex families it is highly variable, although mutations in certain genes, notably spastic paraplegia gene (SPG) 3A/atlastin1, are predominantly associated with a childhood age at onset. (springer.com)
Limbs1
- On admission, neurological examination of his motor power was reduced (0/5) in both lower extremities (paraplegia), tendon reflexes in both lower limbs had increased, Babinski responses were positive, there was anesthesia/hypoesthesia for light touch, and there was hypoesthesia below the thoracal (T5-T6) dermatome. (hindawi.com)
Lead to paraplegia2
- Some chronic conditions can also lead to paraplegia. (medicalnewstoday.com)
- Several causes can lead to paraplegia. (pfaffgill.com)
Individuals with Paraplegia5
- Individuals with paraplegia can range in their level of disability, requiring treatments to vary from case to case. (wikipedia.org)
- Quality Of Life of Individuals with Paraplegia in Punjab. (ozon.ru)
- The information about Quality of Life of individuals with Paraplegia in developing countries has not been reported extensively. (ozon.ru)
- The project is an effort to evaluate the Quality Of Life of individuals with Paraplegia in Punjab via application of scales for ambulatory status, functional independence and community reintegration. (ozon.ru)
- The aim of this study is to assess the impact of gait training using H-MEX powered exoskeleton on walking ability, gait analysis, medical examination, body composition, functional evaluation, laboratory findings, quality of life, and subjective experience in individuals with paraplegia. (bioportfolio.com)
Quadriplegia and paraplegia2
- Quadriplegia and paraplegia are most often caused by spinal cord injuries. (winchesterhospital.org)
- How are quadriplegia and paraplegia treated? (oshmanlaw.com)
Pure hereditary1
- Spastic paraplegia type 3A is usually a pure hereditary spastic paraplegia, although a few complex cases have been reported. (medlineplus.gov)
20171
- Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia appeared in the April 2017 issue of Mayo Clinic Proceedings. (mayoclinic.org)
Sensory4
- Paraplegia is an impairment in motor or sensory function of the lower extremities. (wikipedia.org)
- This page presents a variety of statistics about Neuropathy sensory spastic paraplegia. (rightdiagnosis.com)
- The term 'prevalence' of Neuropathy sensory spastic paraplegia usually refers to the estimated population of people who are managing Neuropathy sensory spastic paraplegia at any given time. (rightdiagnosis.com)
- The term 'incidence' of Neuropathy sensory spastic paraplegia refers to the annual diagnosis rate, or the number of new cases of Neuropathy sensory spastic paraplegia diagnosed each year. (rightdiagnosis.com)
Sudden onset5
- We present idiopathic spontaneous hematomyelia of a previously healthy 80-year-old male with a sudden onset of back pain and paraplegia. (hindawi.com)
- Described is a case of a 46-year-old female who presented with the sudden onset of nontraumatic low back pain with rapidly progressive paraplegia which was subsequently determined to be of vascular origin. (hindawi.com)
- Presented is a rare case of aortic saddle embolism associated with the sudden onset of low back pain and acute onset paraplegia. (hindawi.com)
- The patient is a 60-year-old female with sudden onset of paraplegia for the last 2 days. (spineuniverse.com)
- A 25-year-old man with Crohn's disease presented to the emergency department with sudden onset bilateral leg pain, paraplegia and loss of anal sphincter tone. (bmj.com)
Cause paraplegia1
- Damage to the brain or spinal cord can cause paraplegia or quadriplegia. (medicalnewstoday.com)
Causes Paraplegia2
- What Causes Paraplegia? (news-medical.net)
- If you have an injury that causes paraplegia, emergency treatment is needed to prevent further damage to the nervous system. (doctors-hospital.net)
Chronic paraplegia2
- The system was tested on two patients with chronic paraplegia. (healthcanal.com)
- Symptomatic treatments used for other forms of chronic paraplegia are sometimes helpful. (wikidoc.org)
Complete paraplegia3
- Reexamination revealed pallor to the lower extremities, nonpalpable distal pulses, and decreased temperature to touch with near complete paraplegia. (hindawi.com)
- Complete paraplegia is extremely rare in EMH due to thalassemia although it is known to occur in polycythemia vera and sickle cell anemia. (haematologica.org)
- Only isolated reports have described patients with complete paraplegia, none of whom have been treated with radiotherapy alone. (haematologica.org)
Neurology1
- This volume in the Blue Books of Neurology series provides rapid access to essential information on the clinical features, differential diagnosis, genetic testing, and management of a broad group of spinocerebellar degenerative disorders, including ataxias and spastic paraplegias. (elsevier.com)
Refers6
- Hereditary spastic paraplegia (HSP) refers to a group of familial diseases that are characterized by progressive degeneration of the corticospinal tracts. (uptodate.com)
- Paraplegia refers to paralysis that occurs in the lower half of the body. (medicalnewstoday.com)
- Paraplegia refers to the loss of movement and sensation in both legs and, sometimes, part of the lower abdomen. (medicalnewstoday.com)
- Paraplegia refers to complete or partial paralysis in both legs and, in some people, parts of the lower abdomen. (medicalnewstoday.com)
- Hereditary spastic paraplegia (HSP) refers to a collection of heterogeneous genetic disorders, rather than a single disease. (natureasia.com)
- Paraplegia refers to involvement of both legs. (healthtap.com)
Onset3
- Acute onset paraplegia has a myriad of causes most often of a nonvascular origin. (hindawi.com)
- The onset of nontraumatic paraplegia represents a significant event for the patient and an emergent diagnostic challenge for the clinician. (hindawi.com)
- Because the patient was 60-years-old and had experienced a rapid onset of paraplegia, surgery was preferred. (spineuniverse.com)
Etiology1
- The etiology of paraplegia is broad and includes disorders of the spinal cord which encompass external compression, infection, ischemia, and other nonspinal disorders. (hindawi.com)
Ataxias1
- Classification of the hereditary ataxias and paraplegias. (uptodate.com)
Paralysis of the legs3
- Paraplegia , paralysis of the legs and lower part of the body. (britannica.com)
- Paraplegia is paralysis of the legs (no movement or feeling). (healthtap.com)
- The hereditary spastic paraplegias (HSPs) are a group of genetic conditions in which spastic paralysis of the legs is the principal clinical feature. (springer.com)
Mutations4
- Mutations in the SPG7 gene cause spastic paraplegia type 7. (medlineplus.gov)
- Mutations affecting reticulon or REEP proteins, with intramembrane hairpin domains that model ER membranes, cause an axon degenerative disease, hereditary spastic paraplegia (HSP). (elifesciences.org)
- It is known that spastic paraplegias are sometimes caused by mutations affecting proteins that help to build and shape the endoplasmic reticulum, for example, the proteins of the reticulon and REEP families. (elifesciences.org)
- Spastic paraplegia 7 is an autosomal recessive disorder caused by mutations in the gene encoding paraplegin, a protein located at the inner mitochondrial membrane and involved in the processing of other mitochondrial proteins. (uib.no)
Clinical8
- HSPs are clinically differentiated into 'pure' forms if spastic paraplegia with bladder involvement is the only clinical finding, and 'complicated' (or complex) forms if there are additional neurologic or systemic abnormalities. (uptodate.com)
- A study by Schlipf et al indicates that since clinical parameters alone are not reliable enough to differentiate between types of hereditary spastic paraplegia (HSP), specifically autosomal recessive (AR) HSP, that amplicon-based high-throughput genotyping followed by pooled next-generation sequencing (NGS) is a much more efficient approach. (medscape.com)
- Clinical severity was assessed by the Spastic Paraplegia Rating Scale. (uni-muenchen.de)
- PAPA-ARTiS is a multi-national, prospective, open-label, two-arm, randomized controlled trial to demonstrate, that a minimally invasive staged treatment approach can reduce paraplegia and mortality in patients undergoing thoracoabdominal aortic aneurysm (TAAA) repair and to assess the clinical safety of the novel therapeutic concept (MIS2ACE). (europa.eu)
- To describe the clinical, genetic, and epidemiologic features of hereditary spastic paraplegia (HSP) in Canada and to determine which clinical, radiologic, and genetic factors determine functional outcomes for patients with HSP. (ovid.com)
- To evaluate the prognostic significance of various clinical, radiological, and neurophysiological findings in conservatively treated patients with Pott's paraplegia, using multiple regression analysis. (bmj.com)
- 6- 9 In the present communication we report the role of various clinical, MRI, and evoked potential changes in predicting the six month outcome of conservatively treated patients with Pott's paraplegia. (bmj.com)
- Briefly, the typical clinical picture is of a slowly progressive, predominantly symmetrical, spastic paraplegia. (springer.com)
Disorders7
- Paraplegia may be caused by injury to or disease of the lower spinal cord or peripheral nerves or by such brain disorders as cerebral palsy . (britannica.com)
- Hereditary spastic paraplegia (HSP) is not a single entity, but a group of clinically and genetically diverse hereditary degenerative disorders that have in common degeneration of the corticospinal tracts and posterior column tracts in the spinal cord . (encyclopedia.com)
- Neurologists, doctors who specialize in brain and nervous system disorders, often diagnose and treat individuals with hereditary spastic paraplegia. (wisegeek.com)
- ObjectiveHereditary spastic paraplegias (HSPs) are genetically driven disorders with the hallmark of progressive spastic gait disturbance. (uni-muenchen.de)
- The research also sheds light on the hereditary spastic paraplegias (HSP), a group of inherited neurological disorders in which some of the longest neurons in the body fail to grow and function properly. (nih.gov)
- This study provides us with valuable new insights that will stimulate research toward therapies for hereditary spastic paraplegias," says Craig Blackstone, M.D., Ph.D., an investigator at NIH's National Institute of Neurological Disorders and Stroke (NINDS) and an HSP expert. (nih.gov)
- Hereditary spastic paraplegia (HSP) is one of the most genetically heterogeneous neurological disorders. (mdpi.com)
HSPs2
- Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative diseases causing progressive gait dysfunction. (sdbonline.org)
- The locomotor deficits in the hereditary spastic paraplegias (HSPs) reflect degeneration of upper motor neurons, but the mechanisms underlying this neurodegeneration are unknown. (sdbonline.org)
Treatments4
- This article will discuss what paraplegia is, as well as the different causes and treatments associated with the condition. (medicalnewstoday.com)
- There are currently no treatments to prevent or reverse paraplegia. (medicalnewstoday.com)
- Data from patients with spastic paraplegia of unknown origin, who reported starting treatments within the last 5 years. (patientslikeme.com)
- Surgery, physical therapy and medications are among the treatments for paraplegia. (pfaffgill.com)
Disease4
- Primary outcome assessment of this study was the change between baseline and follow-up assessment in treatment to control group in the spastic paraplegia rating scale (SPRS) score as a validated measure of disease severity (see Reference). (clinicaltrials.gov)
- The study, which is published in the July 13 issue of the journal Current Biology, provides a provocative new insight into the molecular basis of the disease called hereditary spastic paraplegia (HSP) and suggests a new way to treat the inherited genetic disorder. (innovations-report.com)
- Although successful aortic repair techniques cure the disease, there is a high risk of paraplegia due to impaired blood supply to the spinal cord during the procedure, particularly for aneurysms extending from the thoracic to the abdominal aorta (thoracoabdominal aortic aneurysms, TAA). (europa.eu)
- Paraplegia is the loss of power in the lower extremities usually due to spinal cord (spastic variety) or peripheral nerve and muscle disease (flaccid type) amputee is a person who has had part or the whole of a limb removed this could be due to a variety of causes from vascular disease trauma or cancer . (healthtap.com)
Group of inherited diseases1
- Hereditary spastic paraplegia (HSP) is a group of inherited diseases whose main feature is a progressive gait disorder. (wikipedia.org)
Gene3
- Here, we have demonstrated that the two most common autosomal recessive hereditary spastic paraplegia gene products, the SPG15 protein spastizin and the SPG11 protein spatacsin, are pivotal for autophagic lysosome reformation (ALR), a pathway that generates new lysosomes. (jci.org)
- A hereditary spastic paraplegia that has_material_basis_in mutation in the PLP1 gene on chromosome Xq22.2. (jax.org)
- A hereditary spastic paraplegia that has_material_basis_in mutation in the SPG11 gene on chromosome 15q21. (jax.org)
Weakness3
- In uncomplicated hereditary paraplegia, patients usually experience mostly muscle weakness and stiffness in the legs. (wisegeek.com)
- Paraplegia= weakness or paralysis of the 2 lower extremities. (healthtap.com)
- Patients with Pott's paraplegia are likely to recover completely by six months if they have mild weakness, lower paraplegia score and normal SEPs and MEPs. (bmj.com)
Neurological1
- The major neurological deficit resulting from spinal ischemic injury is the loss of motor function in lower extremities, also called paraplegia. (ca.gov)