Air-filled spaces located within the bones around the NASAL CAVITY. They are extensions of the nasal cavity and lined by the ciliated NASAL MUCOSA. Each sinus is named for the cranial bone in which it is located, such as the ETHMOID SINUS; the FRONTAL SINUS; the MAXILLARY SINUS; and the SPHENOID SINUS.
Tumors or cancer of the PARANASAL SINUSES.
Diseases affecting or involving the PARANASAL SINUSES and generally manifesting as inflammation, abscesses, cysts, or tumors.
Tumors or cancer of the MAXILLARY SINUS. They represent the majority of paranasal neoplasms.
The air space located in the body of the MAXILLARY BONE near each cheek. Each maxillary sinus communicates with the middle passage (meatus) of the NASAL CAVITY on the same side.
One of the paired, but seldom symmetrical, air spaces located between the inner and outer compact layers of the FRONTAL BONE in the forehead.
The numerous (6-12) small thin-walled spaces or air cells in the ETHMOID BONE located between the eyes. These air cells form an ethmoidal labyrinth.
Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.
Tumors or cancer of the NOSE.
The proximal portion of the respiratory passages on either side of the NASAL SEPTUM. Nasal cavities, extending from the nares to the NASOPHARYNX, are lined with ciliated NASAL MUCOSA.
One of the paired air spaces located in the body of the SPHENOID BONE behind the ETHMOID BONE in the middle of the skull. Sphenoid sinus communicates with the posterosuperior part of NASAL CAVITY on the same side.
A retention cyst of the salivary gland, lacrimal sac, paranasal sinuses, appendix, or gallbladder. (Stedman, 26th ed)
The scroll-like bony plates with curved margins on the lateral wall of the NASAL CAVITY. Turbinates, also called nasal concha, increase the surface area of nasal cavity thus providing a mechanism for rapid warming and humidification of air as it passes to the lung.
Focal accumulations of EDEMA fluid in the NASAL MUCOSA accompanied by HYPERPLASIA of the associated submucosal connective tissue. Polyps may be NEOPLASMS, foci of INFLAMMATION, degenerative lesions, or malformations.
The partition separating the two NASAL CAVITIES in the midplane. It is formed by the SEPTAL NASAL CARTILAGE, parts of skull bones (ETHMOID BONE; VOMER), and membranous parts.
Surgery performed on the ear and its parts, the nose and nasal cavity, or the throat, including surgery of the adenoids, tonsils, pharynx, and trachea.
A benign tumor composed of bone tissue or a hard tumor of bonelike structure developing on a bone (homoplastic osteoma) or on other structures (heteroplastic osteoma). (From Dorland, 27th ed)
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A light and spongy (pneumatized) bone that lies between the orbital part of FRONTAL BONE and the anterior of SPHENOID BONE. Ethmoid bone separates the ORBIT from the ETHMOID SINUS. It consists of a horizontal plate, a perpendicular plate, and two lateral labyrinths.
Inflammation of the NASAL MUCOSA in the SPHENOID SINUS. Isolated sphenoid sinusitis is uncommon. It usually occurs in conjunction with other paranasal sinusitis.
Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.
Diagnostic measurement of the nose and its cavity through acoustic reflections. Used to measure nasal anatomical landmarks, nasal septal deviation, and nasal airway changes in response to allergen provocation tests (NASAL PROVOCATION TESTS).
Inflammation of the NASAL MUCOSA in the FRONTAL SINUS. In many cases, it is caused by an infection of the bacteria STREPTOCOCCUS PNEUMONIAE or HAEMOPHILUS INFLUENZAE.
Bleeding from the nose.
Disorders of the nose, general or unspecified.
Neoplasms of the bony orbit and contents except the eyeball.
Abnormal protrusion of both eyes; may be caused by endocrine gland malfunction, malignancy, injury, or paralysis of the extrinsic muscles of the eye.
Bony cavity that holds the eyeball and its associated tissues and appendages.
Abnormalities of the nose acquired after birth from injury or disease.
A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)
Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
Inflammation of the NASAL MUCOSA in the ETHMOID SINUS. It may present itself as an acute (infectious) or chronic (allergic) condition.
Large endothelium-lined venous channels situated between the two layers of DURA MATER, the endosteal and the meningeal layers. They are devoid of valves and are parts of the venous system of dura mater. Major cranial sinuses include a postero-superior group (such as superior sagittal, inferior sagittal, straight, transverse, and occipital) and an antero-inferior group (such as cavernous, petrosal, and basilar plexus).
Diseases of the bony orbit and contents except the eyeball.
Any hindrance to the passage of air into and out of the nose. The obstruction may be unilateral or bilateral, and may involve any part of the NASAL CAVITY.
Plugs or cylinders made of cotton, sponge, or other absorbent material. They are used in surgery to absorb fluids such as blood or drainage.
An autosomal recessive disorder characterized by a triad of DEXTROCARDIA; INFERTILITY; and SINUSITIS. The syndrome is caused by mutations of DYNEIN genes encoding motility proteins which are components of sperm tails, and CILIA in the respiratory and the reproductive tracts.
The compartment containing the anterior extremities and half the inferior surface of the temporal lobes (TEMPORAL LOBE) of the cerebral hemispheres. Lying posterior and inferior to the anterior cranial fossa (CRANIAL FOSSA, ANTERIOR), it is formed by part of the TEMPORAL BONE and SPHENOID BONE. It is separated from the posterior cranial fossa (CRANIAL FOSSA, POSTERIOR) by crests formed by the superior borders of the petrous parts of the temporal bones.
Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).
Fractures of the upper jaw.
An irregularly shaped venous space in the dura mater at either side of the sphenoid bone.
The dilatation of the aortic wall behind each of the cusps of the aortic valve.
A mucosal tumor of the urinary bladder or nasal cavity in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded than in other papillomas. (Stedman, 25th ed)
Inflammation of the NASAL MUCOSA in the MAXILLARY SINUS. In many cases, it is caused by an infection of the bacteria HAEMOPHILUS INFLUENZAE; STREPTOCOCCUS PNEUMONIAE; or STAPHYLOCOCCUS AUREUS.
Congenital abnormalities in which the HEART is in the normal position (levocardia) in the left side of the chest but some or all of the THORAX or ABDOMEN viscera are transposed laterally (SITUS INVERSUS). It is also known as situs inversus with levocardia, or isolated levocardia. This condition is often associated with severe heart defects and splenic abnormalities such as asplenia or polysplenia.
A part of the upper respiratory tract. It contains the organ of SMELL. The term includes the external nose, the nasal cavity, and the PARANASAL SINUSES.
Pharmacologic agents delivered into the nostrils in the form of a mist or spray.
The dilated portion of the common carotid artery at its bifurcation into external and internal carotids. It contains baroreceptors which, when stimulated, cause slowing of the heart, vasodilatation, and a fall in blood pressure.
The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.
A product of hard secondary xylem composed of CELLULOSE, hemicellulose, and LIGNANS, that is under the bark of trees and shrubs. It is used in construction and as a source of CHARCOAL and many other products.
A branch of biology dealing with the structure of organisms.
An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).
The inferior region of the skull consisting of an internal (cerebral), and an external (basilar) surface.
Infection in humans and animals caused by any fungus in the order Mucorales (e.g., Absidia, Mucor, Rhizopus etc.) There are many clinical types associated with infection of the central nervous system, lung, gastrointestinal tract, skin, orbit and paranasal sinuses. In humans, it usually occurs as an opportunistic infection in patients with a chronic debilitating disease, particularly uncontrolled diabetes, or who are receiving immunosuppressive agents. (From Dorland, 28th ed)
A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures.
Formation or presence of a blood clot (THROMBUS) in the CRANIAL SINUSES, large endothelium-lined venous channels situated within the SKULL. Intracranial sinuses, also called cranial venous sinuses, include the superior sagittal, cavernous, lateral, petrous sinuses, and many others. Cranial sinus thrombosis can lead to severe HEADACHE; SEIZURE; and other neurological defects.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.
Infections with fungi of the genus ASPERGILLUS.
The act of BREATHING out.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Pneumocephalus associated with ethmoidal sinus osteoma--case report. (1/249)

A 35-year-old female suffered sudden onset of severe headache upon blowing her nose. No rhinorrhea or signs of meningeal irritation were noted. Computed tomography (CT) with bone windows clearly delineated a bony mass in the right ethmoid sinus, extending into the orbit and intracranially. Conventional CT demonstrated multiple air bubbles in the cisterns and around the mass in the right frontal skull base, suggesting that the mass was associated with entry of the air bubbles into the cranial cavity. T1- and T2-weighted magnetic resonance (MR) imaging showed a low-signal lesion that appeared to be an osteoma but did not show any air bubbles. Through a wide bilateral frontal craniotomy, the cauliflower-like osteoma was found to be protruding intracranially through the skull base and the overlying dura mater. The osteoma was removed, and the dural defect was covered with a fascia graft. Histological examination confirmed that the lesion was an osteoma. The operative procedure resolved the problem of air entry. CT is superior to MR imaging for diagnosing pneumocephalus, by providing a better assessment of bony destruction and better detection of small amounts of intracranial air.  (+info)

Benign expansile lesions of the sphenoid sinus: differentiation from normal asymmetry of the lateral recesses. (2/249)

BACKGROUND AND PURPOSE: There is a wide range of normal variation is sphenoid sinus development, especially in the size of the lateral recesses. The purpose of this study was to determine imaging characteristics that may help differentiate between opacification of a developmentally asymmetric lateral recess and a true expansile lesion of the sphenoid sinus. METHODS: Coronal CT was performed in seven patients with expansile or erosive benign lesions of the sphenoid sinus, and results were compared to a control population of 72 subjects with unopacified sphenoid sinuses. The degree of asymmetry of lateral recess development was assessed with particular attention to the separation of vidian's canal and the foramen rotundum (vidian-rotundum distance). The images were also examined for evidence of: erosion, defined as loss of the normal thin bony margin on at least two contiguous sections; apparent thinning of the sinus wall, defined as a focal apparent decrease in thickness again on at least two contiguous sections; and for vidian's canal or foramen rotundum rim erosion or flattening. RESULTS: Of the seven patients with expansile lesions, vidian's canal margin erosion was present in seven, unequivocal sinus expansion in three, wall erosion in three, wall thinning in three, erosion of the foramen rotundum in two, and flattening in the foramen rotundum in four. Forty-one of the 72 controls had lateral recess formation, 28 of which were asymmetric. The distance between vidian's canal and the foramen rotundum (vidian-rotundum distance) relied on the presence or absence of pneumatization, with a significantly larger distance in the presence of greater wing pneumatization. Examination of 24 controls revealed apparent thinning of the sinus wall, typically at the carotid groove, but no flattening, thinning, or erosion of the vidian canal or of the foramen rotundum. CONCLUSION: Examination of controls and patients with expansile or erosive lesions of the sphenoid sinus revealed side-to-side asymmetry in the development of the sinus and lateral recess, making subtle expansion difficult to assess. Furthermore, variability in the vidian-rotundum distance correlated with degree of pneumatization, and did not necessarily reflect expansion. Thus, in the absence of gross sinus wall erosion, flattening or erosion of the rims of vidian's canal or the foramen rotundum provides the most specific evidence of an expansile or erosive process within the sinus.  (+info)

Amphicrine tumor. (3/249)

The term amphicrine refers to cells, and tumors, which show both exocrine and endocrine features. Author s aim was to analyse the characteristics of these neoplasms. 40 suspicious cases were reviewed. Mucin-stains (PAS, diastase-PAS, Stains-all, Alcian-blue), immunohistochemistry (antibodies against Neuron-Specific Enolase (NSE), and Chromogranin A (CGA), and electronmicroscopic studies were performed to demonstrate exocrine and/or endocrine features of the tumor cells. By means of these methods, 16 cases turned out to be amphicrine tumors. Among them, there were 4 sinonasal, 1 bronchial, 1 mediastinal, 8 gastrointestinal and 2 suprarenal gland neoplasms. In connection to the subject, a brief review is given of amphicrine tumor, regarding its etiological and pathological aspects. These tumors form a distinct clinicopathological entity and should be separated from both neuroendocrine tumors and adenocarcinomas.  (+info)

Recurrent inverted papilloma: diagnosis with pharmacokinetic dynamic gadolinium-enhanced MR imaging. (4/249)

BACKGROUND AND PURPOSE: Dynamic gadolinium-enhanced MR imaging has been used successfully to identify post-treatment recurrence or postoperative changes in rectal and cervical carcinoma. Our purpose was to evaluate the usefulness of dynamic gadolinium-enhanced MR imaging for distinguishing recurrent inverted papilloma (IP) from postoperative changes. METHODS: Fifteen patients with 20 pathologically proved lesions (recurrent IP, 12; fibrosis or granulation tissue, eight) were enrolled in the study. Three observers, blinded to pathologic results, independently evaluated conventional MR images, including T1-weighted (unenhanced and postcontrast), proton-density-weighted, and T2-weighted spin-echo images. Results then were determined by consensus. Dynamic images were obtained using fast spin-echo sequences at 5, 30, 60, 90, 120, 150, 180, and 300 seconds after the injection of gadolinium-diethylene-triamine penta-acetic acid. Time-signal intensity curves of suspected lesions were analyzed by a pharmacokinetic model. The calculated amplitude and tissue distribution time were used to characterize tissue, and their values were displayed as a color-coded overlay. RESULTS: T2-weighted images yielded a sensitivity of 67%, a specificity of 75%, and an accuracy of 70% in the diagnosis of recurrent IP. Contrast-enhanced T1-weighted images yielded a sensitivity of 75%, a specificity of 50%, and an accuracy of 65%. Pharmacokinetic analysis showed that recurrent IP had faster (distribution time, 41 versus 88 seconds) and higher (amplitude, 2.4 versus 1.2 arbitrary units) enhancement than did fibrosis or granulation tissue. A cut-off of 65 seconds for distribution time and 1.6 units for amplitude yielded a sensitivity of 100% and a specificity of 100% for diagnosing recurrent IP. CONCLUSION: Dynamic MR imaging can differentiate accurately recurrent IP from postoperative changes and seems to be a valuable diagnostic tool.  (+info)

Inverted sinonasal papilloma : a molecular genetic appraisal of its putative status as a Precursor to squamous cell carcinoma. (5/249)

Inverted papilloma (IP) is a proliferative lesion of the epithelium lining the sinonasal tract. Although IP often recurs after surgical excision and is sometimes associated with squamous cell carcinoma of the sinonasal cavity (SNSCC), its presumed neoplastic nature and putative role as a precursor to squamous cell carcinoma have not been confirmed at the molecular genetic level. We analyzed the pattern of X chromosome inactivation in IPs from nine female patients. Inactivation of a single allele is seen in monoclonal proliferations and may be indicative of a neoplastic process. We also analyzed 28 IPs and 6 concurrent SNSCCs for loss of heterozygosity (LOH) on chromosomal arms 3p, 9p21, 11q13, 13q11, and 17p13. Losses at these loci occur frequently during neoplastic transformation of the upper respiratory tract and can be detected in squamous cell carcinomas and the progenitor lesions from which they arise. X chromosome analysis was informative in four of the nine IPs. All four lesions demonstrated a monoclonal pattern of inactivation. LOH was not detected in any nondysplastic areas from the 28 IPs, but LOH at one or more chromosomal loci was present in all six of the concurrent SNSCCs. We conclude that IPs are monoclonal proliferations, yet they do not fit the profile of a prototypic precursor lesion. Unlike squamous epithelial dysplasia, IPs do not routinely harbor several of the key genetic alterations that are associated with malignant transformation of the upper respiratory tract.  (+info)

Cavernous sinus syndrome associated with nonsecretory myeloma. (6/249)

The case of a 53-year-old man who developed cavernous sinus syndrome (CSS) four years after being diagnosed as having nonsecretory myeloma is described. He was admitted with diplopia and dull pain over the right infraorbital and zygomatic region in June 1997. The cause of CSS was the intracranial involvement of myeloma, which was diagnosed by fiberscopic biopsy. The results of endocrinologic evaluation were almost normal. The response to radiotherapy and chemotherapy was mild. CSS caused by nonsecretory myeloma is rare and its prognosis is poor. More aggressive chemotherapy with stem cell support may be indicated.  (+info)

Recurrence of clival chordoma along the surgical pathway. (7/249)

Chordomas are locally aggressive malignant tumors of notochordal origin whose metastatic potential is increasingly recognized. Surgical pathway recurrence has been noted only rarely in the literature. We present three patients with clival chordomas whose sole or initial recurrence was along the pathway of prior surgical access. A characteristic mass found along the pathway of prior surgical access for resection of a chordoma should suggest recurrent chordoma.  (+info)

A case report of sinonasal teratocarcinosarcoma. (8/249)

A sinonasal teratocarcinosarcoma (SNTCS) is a rare and aggressive malignant neoplasm histologically characterized by the combination of one or more epithelial elements and mesenchymal components. We report a case of a 78-year-old man with SNTCS involving the nasal cavity and paranasal sinuses. He complained of epiphora and exophthalmos with weight loss. Physical and diagnostic images resulted T4N0M0. The tumor was completely and widely resected via a trans-facial approach to perform total maxillectomy with orbital exenteration. The clinical presentation, pathologic features, and clinical course are described with a review of the literature.  (+info)

Lesions of the sinonasal tract are uncommon, with most of the specimens seen by surgical pathologists consisting primarily of fragments of inflamed sinonasal mucosa or inflammatory polyps from patients with chronic rhinosinusitis, and the occasional squamous cell carcinoma. Other lesions such as hamartomas, various types of Schneiderian papillomas and adenocarcinomas are seen only rarely by most histopathologists; therefore a biopsy or surgical resection specimen from a patient with one of these processes may represent a diagnostic challenge. The aim of this review is to present the pathological features of a group of infrequent epithelial surface and glandular lesions of the sinonasal tract which includes respiratory epithelial adenomatoid hamartoma, glandular (seromucinous) hamartoma, exophytic papilloma, inverted papilloma, cylindrical cell (oncocytic) papilloma, low-grade sinonasal adenocarcinoma and intestinal-type sinonasal adenocarcinoma. ...
Although the association of subarachnoid hemorrhage (SAH) and tumoral lesions in adult is well known, hemorrhage from a sinonasal carcinoma extending to the intracranial cavity is exceedingly rare. In this paper, the authors report on a 12-year-old girl who presented with SAH caused by a sinonasal carcinoma located in the anterior skull base area. To our knowledge, this is the first report of a sinonasal carcinoma concomitant with SAH. ...
TY - JOUR. T1 - Extent of surgery in the management of locally advanced sinonasal malignancies. AU - Resto, Vicente. AU - Chan, Annie W.. AU - Deschler, Daniel G.. AU - Lin, Derrick T.. PY - 2008/2. Y1 - 2008/2. N2 - Background. The relative importance of surgery within multimodality regimens commonly used to treat advanced sinonasal malignancies remains unknown. Methods. One hundred two patients with locally advanced sinonasal cancers treated with proton beam radiation therapy with or without surgery were retrospectively reviewed. Extent of surgery and outcome variables of local control, disease-free survival, and overall survival were evaluated. Patterns of failure were also assessed. Results. Extent of surgery correlated with disease-free survival and overall survival rates. Local control rate, however, was independent of the degree of surgical resection achieved. Overall, treatment failure most commonly resulted from distant metastases, which occurred in 30% of patients and also correlated ...
Sinonasal adenocarcinoma: Find the most comprehensive real-world symptom and treatment data on sinonasal adenocarcinoma at PatientsLikeMe. 1 patients with sinonasal adenocarcinoma experience fatigue, depressed mood, pain, and anxious mood.
(HealthDay)-Pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) can predict survival for patients with primary sinonasal cancers (SNCs), according to a study published online Dec. 29 ...
TY - JOUR. T1 - Low prevalence of K-RAS, EGF-R and BRAF mutations in sinonasal adenocarcinomas. Implications for anti-EGFR treatments. AU - Franchi, Alessandro. AU - Innocenti, Duccio Rossi Degli. AU - Palomba, Annarita. AU - Miligi, Lucia. AU - Paiar, Fabiola. AU - Franzese, Ciro. AU - Santucci, Marco. PY - 2014. Y1 - 2014. N2 - We have previously shown that a subset of sinonasal intestinal-type adenocarcinomas (ITAC) shows activation of the epidermal growth factor-receptor (EGFR) pathway. In this study we examine the status of the EGFR, KRAS and BRAF genes in a series of sinonasal intestinal (ITAC) and non-intestinal type adenocarcinomas (non-ITAC). Eighteen ITACs and 12 non-ITACs were studied immunohistochemically for EGFR expression. Point mutations were analyzed for EGFR exons 19 and 21, KRAS exon 2 and BRAF exon 15 by direct sequencing. Non-ITACs showed significantly higher expression of EGFR (p = 0.015). Mutation analysis revealed one ITAC with EGFR and one ITAC with KRAS mutation, while ...
Sinonasal carcinomas (SNCs) comprise various rare tumor types that are characterized by marked histologic diversity and largely unknown molecular profiles, yet share an overall poor prognosis owing to an aggressive clinical course and frequent late-stage diagnosis. The lack of effective systemic therapies for locally advanced or metastatic SNC poses a major challenge to therapeutic decision making for individual patients. Here, we used whole-exome and transcriptome sequencing to identify a KIT exon 11 mutation (c.1733_1735del, p.578_579del) as actionable target in a patient with metastatic SNC whose tumor, despite all diagnostic efforts, could not be assigned to any known SNC category and was refractory to multimodal therapy. Molecularly guided treatment with imatinib resulted in a dramatic and durable response with remission of nearly all tumor manifestations, indicating a dominant driver function of mutant KIT in this tumor. This observation highlights the potential of unbiased genomic ...
BACKGROUND: Long-term trends of sinonasal cancer in The Netherlands have been investigated with particular attention on adenocarcinoma for which wood or leather dust is a well-known risk factor. METHODS: All 4345 patients (1989-2014) registered in the Netherlands Cancer Registry were included. Standardized 3-year moving incidence rates per 1 000 000/person-years, and estimated annual percentage change (EAPC) were calculated. RESULTS: Forty-seven percent of the patients had squamous cell carcinoma (SCC), 12% had lymphoma, and 12% had adenocarcinoma. Sixty-one percent of the tumors were located in the nasal cavity, 22% in the maxillary, and 11% in the ethmoidal sinus. Male incidence decreased to 11.5/1 000 000 due to less SCC (EAPC -0.9%; 95% confidence interval [CI] -1.6 to 0.3) and adenocarcinoma (EAPC -4.3%; 95% CI -5.5 to 3.1). Female incidence increased to 7/1 000 000 (EAPC +2.0%; 95% CI +1.1 to +3.0) due to more SCC (EAPC +2.2%; 95% CI +1.0 to +3.5), whereas adenocarcinoma remained stable ...
Sinonasal cancer is a rare form of cancer that is often caused by occupational or environmental exposures to certain substances. Contact our attorneys today
Sinonasal cancer is a ticking time bomb! If you or a loved one has been diagnosed with it, discuss your legal rights and options with a qualified attorney.
In the head and neck, about 60% of lymphomas have an extranodal origin (Quraishi et al. 2000). Sinonasal tract may be involved by primary lesions (nasal cavity T-NK lymphoma and marginal zone B-cell lymphoma) and secondary lesions. For primary neoplasms, it is possible an exclusive localization within the sinonasal tract; conversely, all secondary lesions should be considered as a systemic disease. Sinonasal lesions, either primary or secondary, are mostly non-Hodgkin lymphomas, while Hodgkin lymphoma is very rarely encountered.. A difference in terms of neoplastic cells subtype, epidemiology, and site of origin between Western World and Far East is well known. In the Western World, non-Hodgkin lymphomas are mainly B-cell subtype and sinonasal tract involvement varies between 0.2 and 2% of all non-Hodgkin lymphomas (Quraishi et al. 2000). In Far East and South America instead, the most frequent cell subtype is T or NK (Nakamura et al. 1997). In the Western World, non-Hodgkin lymphomas tend to ...
A combination of computed tomography (CT) and magnetic resonance imaging (MRI) is now established as the optimum assessment of sinonasal malignancy. CT and MRI are of particular value in assessing the skull base, orbit and pteryo-palatine and infratemporal fossae. Although MRI offers better differentiation of tumour from surrounding tissue and fluid, coronal CT is still required for the demonstration of bone erosion particularly in the region of the cribriform plate. Thus the extent of local tumour spread may be determined with a degree of accuracy in excess of 98 per cent. However, the final determinant of penetration of the dura and orbital periosteum requires per-operative frozen section assessment. A knowledge of the tissue characteristics and site of origin can be of value in distinguishing some of the commoner sinonasal malignancies such as squamous cell carcinoma, adenocarcinoma, adenoid cystic carcinoma, olfactory neuroblastoma and chondrosarcoma. Imaging, particularly MRI also plays an ...
8 Prognostic factors were analysed in tumours from 98 patients diagnosed with IP in Stockholm between 2000-2010. In total, 12.2% of the IPs were HPV positive and p16 overexpression was found in the only high-risk HPV positive tumour. Patients with HPV positive lesions were younger and tended to present with more dysplasia and to relapse less frequently. The tumours also had a higher proportion of EGFR expression compared to HPV negative tumours (91.7% and 52.3%, respectively). Stathmin was expressed by the tumours cells and not at all or weakly in the normal mucosa and more specimens with dysplasia were stathmin-positive than specimens without dysplasia (40.0% as compared to 12.6%). Stathmin positive IPs also tended to have earlier recurrences, although this difference was not statistically significant. No correlation was observed between TILs or EGFR and prognosis ...
Outline: Anatomy Epidemiology Presentation Pathology Orbital Invasion Evaluation Management Sequela Disease-specific management Research Presentation: 35:18 PowerPoint slides located at bottom of this page.
It is believed that cancers arising in the sinonasal cavity and the base of skull are tremendously uncommon. It has been estimated that the occurrence of
ConclusionsManagement of SNAC consists of histological diagnosis, radiological staging, radical surgery, and adjuvant radiation therapy. Neoadjuvant chemotherapy can be indicated in selected cases. The role of biotherapy and immune therapy still needs to be elucidated....
Not necessarily. Although Brownie was healthy and happy, he began to get severe arthritis the last few months of his life. He began to limp, and he would walk places, but lay down as soon as he got there. He did not get up until he had to, and never stood longer than necessary. I began to panic because I was prepared to help him pass when the cancer took over, but I didnt think I could look him in the eye and do it if he went lame, but still felt happy and had no pain (provided he wasnt standing). I was so scared that was going to be the case. Im not sure I could have done it ...
There are two things you have working in your favor because she is a food hound. The first is that if she quits eating, you will know she has reached a point where you need to change something big. I know this seems kind of obvious, but dogs that are just OK eaters lose their appetites easier, so those owners have to go through more adjustments. Its common for pain meds to affect their appetites, so check on those kinds of things first if she loses her appetite. The other thing about food hounds is that you can (usually) medicate them easier. My lab inhaled everything, so a big pill wrapped in a Pill Pocket was a treat, because it never got chewed. My other dogs will thoroughly chew everything, so they would find a hidden med in a heartbeat. Ive heard you shouldnt ever add meds to any animals meals because they could begin rejecting the meals. I think thats probably good advice, but if the situation calls for it, I will tell you that I dumped all kinds of supplements and herbs in my labs ...
Nasal Sinus, Pharynx, Mouth,Medical Illustration database of the best portfolios and stock images now features General and Commercial Illustration and illustrators. 8,000+ image database includes all types of subjects and features the largest directory of medical, science, and nature illustrators and illustration on the web.
Each of us at least once became ill with rhinitis (a cold). At the first signs of a mild cold - a cough, a cold, a throat, even without heat, we feel weakness, and our body needs rest and gentle regimen. But in the place of going to bed, we carry rhinitis on the legs, considering this illness serious. As a result, we weaken the protective forces of the body even more and the banal rhinitis passes into the sinusitis - an inflammatory process in the paranasal sinuses of the nose (haemorrhoids). Continue reading →. ...
According to the World Health Organization, IP is defined as a benign epithelial tumor composed of well-differentiated columnar or ciliated respiratory epithelium having variable squamous differentiation.21 Embryologically, the ectodermally derived epithelium of IP originating from the Schneiderian mucosa of the nasal cavity is distinct from the endodermally derived mucosa of the upper respiratory tract.12 Complete surgical resection is crucial to reduce the recurrence rates, which have ranged from 15% to 78%.6-8 Preoperative evaluation by using cross-sectional imaging, such as CT and MR imaging, is essential for the selection of surgical options by correctly identifying the location and extent of the tumor, and postoperative follow-up examinations at regular intervals are also highly recommended for the early detection of the recurrent disease.11-18,22-24 However, differentiation of IP from other malignant sinonasal tumors by analyzing the internal characteristics on radiologic imaging is often ...
Objective To evaluate the oncologic outcomes of patients with sinonasal cancer treated with endoscopic resection.. Design Retrospective review.. Setting Tertiary care academic cancer center.. Patients All patients with biopsy-proved malignant neoplasm of the sinonasal region who were treated with endoscopic resection between 1992 and 2007 were included in the study, and their charts were reviewed for demographics, histopathologic findings, treatment details, and outcome.. Main Outcome Measures Oncologic outcomes, including disease recurrence and survival.. Results Of a total of 120 patients, 93 (77.5%) underwent an exclusively endoscopic approach (EEA) and 27 (22.5%) underwent a cranioendoscopic approach (CEA) in which the surgical resection involved the addition of a frontal or subfrontal craniotomy to the transnasal endoscopic approach. Of the 120 patients, 41% presented with previously untreated disease, 46% presented with persistent disease that had been partially resected, and 13% presented ...
Inverted papilloma (IP) is a common proliferation of squamous epithelial cells of the sinonasal tract. Although considered benign, IP is known to cause loc
Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Sinonasal Mucocele
english) On the neurocranium, cavities in the nasal capsule that drain the nasal sinuses through the orbitonasal canals into the orbital sinuses. (See also: neurocranium, nasal capsule ...
Breathing is fundamental. You are literally doing it right now. Your lungs, throat and nasal sinuses are always in action so when function is impaired you know right away. These herbs come to the rescue to support healthy respiration.. ...
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Define Paranasal sinus neoplasms. Paranasal sinus neoplasms synonyms, Paranasal sinus neoplasms pronunciation, Paranasal sinus neoplasms translation, English dictionary definition of Paranasal sinus neoplasms. Noun 1. paranasal sinus - any of the paired sinuses in the bones of the face adjacent to the nasal cavity that are lined with mucous membrane that is...
Clinical trial for Paranasal Sinus Cancer | Stage IVB Nasal Cavity and Paranasal Sinus Cancer AJCC v8 | Stage IVA Nasal Cavity and Paranasal Sinus Cancer AJCC v8 | Squamous Cell Carcinoma | Sinonasal Undifferentiated Carcinoma | Squamous cell carcinoma | Nasal Cavity and Paranasal Sinus Poorly Differentiated Carcinoma | Stage III Nasal Cavity and Paranasal Sinus Cancer AJCC v8 | Stage II Nasal Cavity and Paranasal Sinus Cancer AJCC v8 | Locally Advanced Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma , Docetaxel Cisplatin and Fluorouracil in Treating Patients With Previously Untreated Stage II-IV Nasal Cavity and Paranasal Sinus Cancer
Looking for online definition of nasal sinus in the Medical Dictionary? nasal sinus explanation free. What is nasal sinus? Meaning of nasal sinus medical term. What does nasal sinus mean?
Recurrent IDH2 R172X mutations in sinonasal undifferentiated carcinoma - Modern Pathology (2017) Meta-analysis of 701 published cases of sinonasal neuroendocrine carcinoma: The importance of differentiation grade in determining treatment strategy - Oral Oncology 63 (2016) Sinonasal Carcinomas with Neuroendocrine Features: Histopathological Differentiation and Treatment Outcomes - Journal of Neurological Surgery (2016) Treatment modalities in sinonasal undifferentiated carcinoma: an analysis from the national cancer database - International Forum of Allergy & Rhinology (2016) Survival Outcomes for Combined Modality Therapy for Sinonasal Undifferentiated Carcinoma - American Academy of Otolaryngology - Head and Neck Surgery (2016) Survival in unresectable sinonasal undifferentiated carcinoma treated with concurrent intra-arterial cisplatin and radiation - World Journal of Clinical Cases (2015) Sinonasal Undifferentiated Carcinoma (SNUC): the Alberta experience and literature review - Journal of ...
Recurrent IDH2 R172X mutations in sinonasal undifferentiated carcinoma - Modern Pathology (2017) Meta-analysis of 701 published cases of sinonasal neuroendocrine carcinoma: The importance of differentiation grade in determining treatment strategy - Oral Oncology 63 (2016) Sinonasal Carcinomas with Neuroendocrine Features: Histopathological Differentiation and Treatment Outcomes - Journal of Neurological Surgery (2016) Treatment modalities in sinonasal undifferentiated carcinoma: an analysis from the national cancer database - International Forum of Allergy & Rhinology (2016) Survival Outcomes for Combined Modality Therapy for Sinonasal Undifferentiated Carcinoma - American Academy of Otolaryngology - Head and Neck Surgery (2016) Survival in unresectable sinonasal undifferentiated carcinoma treated with concurrent intra-arterial cisplatin and radiation - World Journal of Clinical Cases (2015) Sinonasal Undifferentiated Carcinoma (SNUC): the Alberta experience and literature review - Journal of ...
In a single-center experience reported in the Journal of Clinical Oncology, Amit et al found that among patients with sinonasal undifferentiated carcinoma with a favorable response to induction chemotherapy, disease-specific survival was better in those receiving definitive concurrent chemoradiotherapy vs those receiving definitive surgery. In those without a favorable response to induction therpay, outcomes were better with surgery.. Study Details. The study involved 95 previously untreated patients with sinonasal undifferentiated carcinoma treated between 2001 and 2018 at The University of Texas MD Anderson Cancer Center. Patients were treated with curative intent and received induction therapy with a platinum-based doublet chemotherapy regimen prior to definitive locoregional therapy. Concurrent chemoradiotherapy began within 4 weeks after induction and consisted of two additional doses of platinum and etoposide chemotherapy concurrent with radiation therapy.. The primary endpoint was ...
The recurrent sinonasal inverted papilloma (IP) could be transformed to sinonasal squamous cell carcinoma. We use protein expression patterns by immunohistochemical method to see whether the expression of p53, p16, p21, and p27 belongs to cell-cycle-regulators and PCNA (proliferating cell nuclear antigen) and Ki-67 the proliferation markers in sixty patients with sinonasal inverted papilloma, and 10 of them with squamous cell carcinoma transformation. Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformation of sinonasal tract compared with inverted papilloma were revealed. No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protein) and p53 expression was correlated to sinonasal IP malignant transformation by multivariate survey. However, we found elevated PLUNC expression in IPs with multiple recurrences. Finally, we found that PCNA, p27 may interact with CDK1 which promote IP cell proliferation and correlate to sinonasal squamous
Biphenotypic sinonasal sarcoma is a newly recognized, very rare, low grade malignant tumor of the nasal cavity which formerly was probably included in fibrosarcoma and synovial sarcoma cases. It is newly recognized by the World Health Organization Classification of Head and Neck Tumours. Abbreviations Biphenotypic sinonasal sarcoma (BSNS) Original name: Low-grade sinonasal sarcoma with neural and myogenic features (LGSSNMF), but it is no longer recommended. Definitions A low-grade spindle cell neoplasm of the sinonasal tract associated with overlying respiratory epithelium and showing S100 protein and actin immunoreactivity. The tumor will often affect multiple sites within the upper aerodigestive tract, frequently showing extension into the orbit (25%) or through the cribriform plate (11%) of the ethmoid sinus into the skull base. The patient present with non-specific findings, including difficulty breathing, facial pressure, congestion, pain, and mild epiphora. Often concurrent benign ...
Tests to diagnose nasal cavity and paranasal sinus cancer, such as endoscopy, are done when symptoms are present. Learn about diagnosing nasal cancer.
The optimal treatment of sinonasal undifferentiated carcinoma (SNUC) remains unclear. We report our results on the outcome and toxicity of patients with SNUC treated by a combined modality and attempt to define the optimal treatment strategies by reviewing the literature. Between 1996 and 2010, 21 consecutive patients with SNUC were treated by any combination of surgery, chemotherapy and radiotherapy. End points were local control (LC), regional control (RC), disease-free (DFS), cause-specific (CSS) overall survival (OS), and late toxicity. Organ preservation was defined as visual preservation without orbital exenteration. After median follow-up of 54 months, the 5-year actuarial rates of LC, RC, DFS, CSS, and OS were 80, 90, 64, 74, and 74 % respectively. On multivariate analysis, T-stage and multimodality treatment approach correlated significantly with LC. Elective nodal irradiation was given to 42 % of high-risk node-negative patients. None of them developed regional failure. The overall ...
Human Nose is divided into 3 parts, the External nose, the Vestibule and the Nasal cavity. Today I am going to discuss about the basic science of Nose, Nasal Sinus, Paranasal Sinuses etc. The basic Anatomy of Nose is described in details. Physiology of Nose, Nasal and Paranasal Sinus consists of Blood supply, nerve supply etc. Blood supply is quite …. Read More » ...
Disclosed herein are compositions and methods for the treatment of sinonasal and/or nasopharyngeal diseases or conditions with active agent compositions and formulations administered locally to an individual afflicted with a sinonasal or nasopharyngeal disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted sinonasal structure(s).
Nasal Cancer, Read about Nasal Cancer symptoms, causes, diagnosis, and treatment. Also read Nasal Cancer articles about how to live with Nasal Cancer, and more.
Nasal Cancer, Read about Nasal Cancer symptoms, causes, diagnosis, and treatment. Also read Nasal Cancer articles about how to live with Nasal Cancer, and more.
Nasal Cancer, Read about Nasal Cancer symptoms, causes, diagnosis, and treatment. Also read Nasal Cancer articles about how to live with Nasal Cancer, and more.
Nasal Cancer, Read about Nasal Cancer symptoms, causes, diagnosis, and treatment. Also read Nasal Cancer articles about how to live with Nasal Cancer, and more.
Los Angeles Ear, Nose & Throat doctors, Osborne Head & Neck Institute, specialize in nasal and sinus surgery with successful patient outcomes.
Our findings indicate that over recent decades, there has been a large and continuing fall in mortality from most of the occupational hazards considered. In many cases, this appears to have come about through improved safety, but it also reflects reductions in the numbers of men employed in more hazardous jobs such as coal mining, and falling mortality from some diseases across the whole population. Notable exceptions to the general improvement are diseases caused by asbestos, especially in some construction trades, sinonasal cancer in woodworkers, and injuries by animals and plants in farmworkers, for which there was still no clear decline in excess mortality.. As in our previous report,2 we limited our analysis of trends to men. This was because in the early part of the study period, most women who died at age 20-74 years had spent only limited time in paid work, and during 1979-1990, only 30% had occupations recorded on their death certificates.5 Furthermore, with a few notable exceptions ...
If you want to not only reduce the secretion of mucus from the nasal sinuses and facilitate breathing, but also give preferring more natural medicines, you should pay attention to sprays with ethereal oils. These are drops such as Pinosol and Evkasept, which have anti-inflammatory and antispasmodic effects.. The benefits of these drops are huge. And, in particular, the fact that they do not cause a person any addiction, and thus enough effectively fight most of the viruses and pathogens penetrating the nasal sinuses rights. And, unlike drugs with antibiotics, drops Pinosol and Evkasept do not block the release of mucus, but on the contrary - improve the condition of the mucous membrane, heal it and restore it.. Remember that the effect of drops with a natural composition is cumulative. You may not get rid of a cold in 1 day, and thats right. The effect of drugs with a natural composition is directed to a gradual step-by-step treatment, rather than to an instant result. Since the composition of ...
Among all melanomas, the mucosal type is very rare and may occur in the sino-nasal mucosa, vagina, anus and the oral cavity. alcohol drinking, cigarette smoking and irradiation [1,4,5]. The prognosis is usually poor, with a five-year survival rate of 30C35% and a median survival of 36 months [4,5]. Recently, many additional treatment options have been adopted for cutaneous melanoma, including targeted therapies and immunotherapies, which were proven effective to guarantee prolonged survival rates [3]; nevertheless, the use of such book remedies to MM is still somehow tied to the low number of instances and the down sides of performing sufficient scientific trials. Many situations of MM from the comparative mind and throat have already been reported in the books, but frequently simply no very clear proof showed whether such lesions could possibly be considered metastatic or primary. This study reviews over the salient medical and histological features Cholecalciferol of one case of MM and shows ...
Sinonasal melanoma represents the most common mucosal site of melanoma in the head and neck, although cutaneous melanomas are more common by a factor of at least 10-20. It is notable (together with mucosal melanoma arising in other parts of the head and neck) for a poor prognosis and unique staging system.. ...
Durr et al developed a simple score for evaluating patients during sinonasal endoscopy. The score correlates with other measures of rhinosinusitis. The authors are from the University of California in San Francisco.
In primul rand, parintele trebuie sa inteleaga ca oxiurus urios verme de furie sunt normale la un copil care vrea sa fie independent si comportamentul acestuia nu este un rezultat al educatiei oferite. Un test tratamentul și prevenirea helmintiazei pediatrice urină controale diferite componente de urina, manipularea în siguranță a viermilor la copii produs rezidual de la rinichi. Colposcopia Se realizeaza de catre medic cu ajutorul unui instrument numit colposcop care lumineaza si mareste visual suprafata colului uterin.
Grupul de Lucru a reunit 36 participanþi din 18 þãri, inclusiv reprezentanþi ai multor agenþii ºi organizaþii internaþionale.
A pituitary tumor is a tumor that grows in the pituitary gland - a small gland located behind the nasal sinuses and above the roof the mouth at the base of the skull. The pituitary gland regulates most of the other glands in the body. ...
Learn about facial reconstructive plastic surgery and nasal sinus surgeons in Raleigh. Meet Dr. David Clark and Dr. Kevin Doyle and see their work.
The fifth chakra, at the throat, bridges our inner and outer worlds. It is the gateway between our hearts and heads. Here is where we express our choices and communicate who we are. Here is our center of creativity. The fifth chakra governs: neck shoulders mouth jaw and teeth nasal sinuses vocal chords trachea and…
... represents the most common benign neoplasm of the nose and paranasal sinuses. The cause of osteomata is uncertain, but ... Osteoma of the frontal sinus seen on x-ray Osteoma of the frontal sinus on CT Osteoma Osteosclerosis Familial adenomatous ... "Management of a Large Frontoethmoid Osteoma with Sinus Cranialization and Cranial Bone Graft Reconstruction". International ...
... paranasal sinus neoplasms MeSH C09.603.669.693.575 - maxillary sinus neoplasms MeSH C09.603.692.503 - paranasal sinus neoplasms ... paranasal sinus neoplasms MeSH C09.647.685.693.575 - maxillary sinus neoplasms MeSH C09.647.710.485 - hypopharyngeal neoplasms ... nasopharyngeal neoplasms MeSH C09.775.549.685 - oropharyngeal neoplasms MeSH C09.775.549.685.800 - tonsillar neoplasms The list ... oropharyngeal neoplasms MeSH C09.647.710.685.800 - tonsillar neoplasms MeSH C09.775.350.650 - nasopharyngeal neoplasms MeSH ...
... laryngeal neoplasms MeSH C04.588.443.665.650 - nose neoplasms MeSH C04.588.443.665.650.693 - paranasal sinus neoplasms MeSH ... maxillary sinus neoplasms MeSH C04.588.443.665.710 - pharyngeal neoplasms MeSH C04.588.443.665.710.485 - hypopharyngeal ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588. - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ...
Wilms tumor Esophageal cancer Head and neck cancer Nasopharyngeal carcinoma Oral cancer Oropharyngeal cancer Paranasal sinus ... Marginal zone B-cell lymphoma Mast cell leukemia Mediastinal large B cell lymphoma Multiple myeloma/plasma cell neoplasm ...
... for Patients With Nasal Cavity and Paranasal Sinus Malignancies". Cancer. 126 (9): 1905-1916. doi:10.1002/cncr. ... Two prominent examples are pediatric neoplasms (such as medulloblastoma) and prostate cancer. Irreversible long-term side ... that IMPT can improve local control when compared to passive scattering for patients with nasal cavity and paranasal sinus ...
... paranasal sinuses, lung, and bones. While cases of PBL may present as a primary oral, or, very rarely a skin or lymph node ... The other lymphoid neoplasms within this subgroup are: plasmablastic plasma cell lymphoma (or the plasmacytoma variant of this ... In 2017, this Organization classified PBL as the most common member of a rare subgroup of lymphomas termed lymphoid neoplasms ... Bhattacharyya S, Bains APS, Sykes DL, Iverson BR, Sibgatullah R, Kuklani RM (December 2019). "Lymphoid neoplasms of the oral ...
... paranasal sinuses, muscle, and, rarely, inside the vasculature and sinuses of lymph nodes. As their disease progresses, however ... This lymphoma also belongs to a group of lymphoid neoplasms with plasmablastic differentiation that involve malignant ... List of hematologic conditions Chen BJ, Chuang SS (March 2020). "Lymphoid Neoplasms With Plasmablastic Differentiation: A ... "Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the ...
Nasal polyps are polypoidal masses arising mainly from the mucous membranes of the nose and paranasal sinuses. They are ... Some polyps are tumors (neoplasms) and others are non-neoplastic, for example hyperplastic or dysplastic. The neoplastic ones ... Polyps are commonly found in the colon, stomach, nose, ear, sinus(es), urinary bladder, and uterus. They may also occur ...
Other sites: Rare sites of involvement are the larynx, nasal cavity, paranasal sinuses, thyroid gland, and the thoracic inlet, ... A paraganglioma is a rare neuroendocrine neoplasm that may develop at various body sites (including the head, neck, thorax and ...
The paranasal sinuses surround and drain into the nasal cavity. Nasopharynx - The upper portion of the pharynx, the nasopharynx ... Papillary - In oncology, papillary refers to neoplasms with projections ("papillae", from Latin, 'nipple') that have ... Laryngeal ventricle - (also called the ventricle of the larynx, laryngeal sinus, or Morgagni's sinus) is a fusiform fossa, ... The throat, sinuses, and larynx may also be affected. Signs and symptoms may appear less than two days after exposure to the ...
The most common sites of extranodal disease in Rosai's registry were skin, nasal cavity/paranasal sinuses, soft tissue, eyelid/ ... "Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages". Blood. 127 (22): 2672-2681. ... Sinus histiocytosis with massive lymphadenopathy: a "massive" misnomer. Diagnostic cytopathology, 43(4), pp.315-319. Pulsoni A ... Foucar E, Rosai J, Dorfman R (1990). "Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the ...
The lateral nasal wall and the paranasal sinuses, the superior concha, the middle concha, and the inferior concha, form the ... Neoplasms - malignant and benign tumors Septal hematoma - a mass of (usually) clotted blood in the septum Toxins - chemical ... the internal areas of the ethmoid sinus and the frontal sinus; and (b) the external areas, from the nasal tip to the rhinion: ... the middle meatus provides drainage for the anterior ethmoid sinuses and for the maxillary and frontal sinuses; and the ...
The disease usually consists of malignant tumors in the nasal cavities, paranasal sinuses, palate, tonsils, nasopharynx, ... Dalia S, Shao H, Sagatys E, Cualing H, Sokol L (October 2014). "Dendritic cell and histiocytic neoplasms: biology, diagnosis, ... It presents as a tumor of the head, neck, oral cavity, sinuses or, less commonly, gastrointestinal tact, skin, or other tissues ... Tang VK, Vijhani P, Cherian SV, Ambelil M, Estrada-Y-Martin RM (2018). "Primary pulmonary lymphoproliferative neoplasms". Lung ...
Nasal polyps are polypoidal masses arising mainly from the mucous membranes of the nose and paranasal sinuses. They are ... Some polyps are tumors (neoplasms) and others are nonneoplastic (for example, hyperplastic or dysplastic). The neoplastic ones ... Polyps are commonly found in the colon, stomach, nose, ear, sinus(es), urinary bladder, and uterus. They may also occur ...
Rare Neoplasm of Inferior Turbinate: Extramedullary Plasmacytoma Gökmen et al. Is Performing the Paranasal Sinus CT Before the ... Paranasal Sinus Fungus Ball: Retrospective Analysis of 37 Patients Dinçer et al. ...
keywords = "adenoid cystic carcinoma, head and neck cancer, margins, oral cavity, paranasal sinuses, salivary gland, survival", ...
Reliable Criterion to Exclude Paranasal Sinus Fracture. J Oral Maxillofac Surg. 2020 Jun;78(6):996.e1-996.e6. ... Imaging of penile neoplasm. Semin Ultrasound CT MR. 2007 Aug;28(4):287-96. ... Koedwut S, Kaewlai R, Sudsang T, Kiranantawat K, Wongwaisayawan S. Clear Sinus Sign on Head CT Scan: ...
  • Q. sinus infection and Polups and I can't breath through my nose. (
  • Your paranasal sinuses are small hollow spaces around the nose. (
  • The Embryology, Development and Anatomy of the Nose, Paranasal Sinuses, Nasolacrimal Passageways and Olfactory Organs in Man. (
  • Nose and paranasal sinuses tumors are rare but their clinical signs and symptom's are nonspecific and their diagnosis usually established with delay. (
  • Benign Neoplasms of the Nose and Paranasal Sinuses (2014). (
  • Meningiomas are one of the most common neoplasms of the central nervous system, but in rare cases (1% to 2%) they are diagnosed in extracranial locations such as the nose and paranasal cavities. (
  • Neoplasms located in the area of the nose and paranasal sinuses should be carefully examined on computed tomography (CT) and magnetic resonance imaging (MRI) scans. (
  • Esthesioneuroblastoma is an uncommon malignant neoplasm of nose and paranasal sinuses. (
  • 2. Intraoral exposure of the midfacial skeleton used in various operations on the nose and paranasal sinuses particularly for excision of neoplasms. (
  • 2. Intraoral exposure of the midfacial skeleton used in operations on the nose and paranasal sinuses. (
  • Malignant neoplasms of the nose and paranasal sinuses are not common among the general population. (
  • We present a retrospective study of 291 cases of malignant tumors of the nose and paranasal sinuses that were diagnosed in a northern Romanian population over a period of 35 years. (
  • Joachims, H. Z. / Malignant tumors of the nose and paranasal sinuses : A retrospective review of 291 cases . (
  • Oncocytic Schneiderian papilloma (OSP) is a rare neoplasm of the nose and paranasal sinuses, and is often mistaken histologically for papillary adenocarcinoma or even rhinosporidiosis. (
  • The impact of tobacco smoke on disorders of the nose and paranasal sinuses is less well understood, although there is growing evidence that such exposure can have a significant impact on nasal and sinus function. (
  • Osteoma represents the most common benign neoplasm of the nose and paranasal sinuses. (
  • It is argued by some that certain anatomic variations in the nose can possibly contribute to the blockage of the drainage and ventilation of the ostiomeatal units, therefore increasing the risk of sinus mucosal disease [ 1 , 2 ]. (
  • The complexity of the nose and the paranasal sinuses anatomy as well as its variants may create technical difficulties during surgery. (
  • The RHINOLOGY/ALLERGY AND IMMUNOLOGY discusses evolution of the nose and sinuses, embryology, sinonasal anatomy and physiology, and rhinological assessment. (
  • If you came to a head and neck cancer specialist after having something small removed from your nose or sinuses and found it was cancer only afterwards, your doctor might skip some of the tests and jump to close follow-up or additional treatment. (
  • Then, either through a video projection or looking directly through the telescope, your doctor will place a forcep into your nose, nasopharynx or sinus to take a piece of any suspicious tissue for analysis. (
  • Neoplasms of nose & paranasal sinuses- a. (
  • Trust Dr. Williams and the Ear, Nose & Throat Specialists of Nashville to care for your allergy/sinus, hearing/ear, sleep apnea, thyroid or other head & neck problems. (
  • Recurring patterns of inflammatory sinonasal disease demonstrated on screening sinus CT. (
  • Sinonasal malignant neoplasms are rare tumors that constitute about 3% of tumors in the upper respiratory tract. (
  • Due to the contiguity of the nasal cavities with the paranasal sinuses, identifying the specific site of origin of large sinonasal tumors is often difficult. (
  • Approximately 55% of sinonasal tumors originate from the maxillary sinuses, 35% from the nasal cavities, 9% from the ethmoid sinuses, and the remainder from the frontal and sphenoid sinuses. (
  • Sinonasal inflammatory disease with sinus ostial obstruction is a very common cause of an opacified paranasal sinus. (
  • Sinonasal adenoid cystic carcinoma (SNACC) is a rare malignancy that most commonly arises in the maxillary sinus. (
  • Most osteomas are asymptomatic and are found incidentally when imaging the sinuses either for sinonasal symptoms or for unrelated complaints. (
  • Adenocarcinomas account for 10-20% of all primary malignant neoplasms of the sinonasal tract [ 4 , 5 ]. (
  • The PNSCT sections showing maxillofacial fractures, sinonasal neoplasms and the results of previous surgeries were not included into the study. (
  • Paranasal sinus computed tomography (PNSCT) sections showing maxillofacial fractures, sinonasal neoplasms, sinonasal polyps and patients with previous surgery were not included into the study. (
  • 112 consecutive sinus CT scans were evaluated for the presence of anatomic variants of the sinonasal cavities and the presence of sinonasal disease. (
  • The results showed no statistically significant association between the sinonasal anatomical variations and the pathologies of the paranasal sinus. (
  • Inverted papilloma (IP) or Shneiderian papilloma is a benign neoplasm of the sinonasal cavity that is hallmarked by its locally invasiveness, tendency for recurrence and malignant transformation. (
  • Glomangiopericytomas are soft tissue tumors showing distinct perivascular myoid differentiation in sinonasal region that correspond to less than 0.5% of neoplasms in this region. (
  • Sinonasal melanomas encompass melanoma arising in the nasal cavity and paranasal sinuses. (
  • The clinical, radiographic, and microscopic differential diagnosis revealed sinonasal undifferentiated carcinoma and maxillary sinus carcinoma, with high grade malignant mesenchymal neoplasm suggestive of rhabdomyosarcoma and mucosal malignant melanoma. (
  • Sinonasal Undifferentiated Carcinoma (SNUC) is a rare and highly aggressive neoplasm arising from the nasal cavity. (
  • Conclusions: Sinonasal undifferentiated carcinoma is a high-grade tumor that arises in the nasal and paranasal sinuses and may invade the orbit. (
  • Malignant neoplasms of the sinonasal are uncommon tumors that constitute less than 2% of overall malignancies, and 1.5-3% of upper respiratory tract. (
  • The most frequent location is the maxillary sinus (50-80%) with the ethmoid sinuses ( 2 ) but, due to the junction of the nasal cavities with the paranasal sinuses, determining the origin of advanced sinonasal tumors is often difficult ( 1 , 3 ). (
  • Emphasis is placed upon management of paranasal sinus inflammatory disorders, allergic fungal rhinosinusitis, revision sinus surgery, inhalant allergy, complex frontal sinus disease, revision sinus surgery, cerebrospinal fluid leaks, encephaloceles, minimally invasive approaches to the paranasal sinuses and skull base for resection of benign and malignant sinonasal neoplasms. (
  • The primary head and neck neoplasms involved the maxillary sinus (eight cases), hard palate (one case), and infratemporal fossa (two cases). (
  • Although tumors of the nasal cavities are equally divided between benign and malignant types, most tumors of the paranasal sinuses are malignant. (
  • We treated 46 patients with histologically proven tumors of the paranasal sinuses with IMRT. (
  • IMRT for tumors of the paranasal sinuses is associated with very good tumor control rates. (
  • Lymph node metastases in malignant tumors of the paranasal sinuses: prognostic value and treatment. (
  • Craniofacial resection has been adopted worldwide as the standard therapy for tumors of the paranasal sinuses involving the anterior skull base. (
  • Epithelial papilloma and squamous cell carcinoma of the nasal cavity and paranasal sinuses: a clinicopathologic study. (
  • St. Pierre S, Baker SR. Squamous cell carcinoma of the maxillary sinus: analysis of 66 cases. (
  • The most common cell type for paranasal sinus and nasal cavity cancers is squamous cell carcinoma. (
  • 1 Dulguerov P, Jacobsen MS, Allal AS, Lehmann W, Calcaterra T. Nasal and paranasal sinus carcinoma: are we making progress? (
  • Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses. (
  • However, use of barbiturates and sinus problems other than infection only increased the risk of nasopharyngeal carcinoma. (
  • Squamous cell carcinoma is the most commonly occurring neoplasm in the maxillary sinus, constituting about 70%-80% of cases, while malignant melanoma is responsible for about 0.4%-4% of malignancies in this region. (
  • The clinical features of organized hematoma, such as a mass expanding from the maxillary sinus with bone destruction, resembled those of maxillary carcinoma. (
  • This type of lesion was reported in the Japanese literature in 1917 as a "blood boil of the maxillary sinus" by Tadokoro and is comparatively well known in Japan as one of the differential diagnoses of maxillary carcinoma. (
  • This recurrence, the patient presented with two distinct lesions the larger, inferior lesion filling much of the maxillary sinus and the smaller, superior lesion adjacent to the ethmoid region. (
  • Although metastases from both the nasal cavity and paranasal sinuses may occur, and distant metastases are found in 20% to 40% of patients who do not respond to treatment, locoregional recurrence accounts for the majority of cancer deaths because most patients die of direct extension into vital areas of the skull or of rapidly recurring local disease. (
  • Understanding patients' knowledge and expectations in endoscopic sinus surgery. (
  • Comparison of intranasal fluticasone and budesonide in post-operative endoscopic sinus surgery patients with chronic rhinosinusitis with polyposis: A randomized-controlled trial. (
  • Superior oblique palsy: A complication of endoscopic sinus surgery. (
  • Surgery for Sphenoid Sinus Disease (2015). (
  • Surgical treatments include endoscopic sinus surgery and a craniofacial approach with or without sinus obliteration. (
  • Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis. (
  • The increasing interest in endoscopic sinus surgery has put the anatomy of the paranasal sinus on the spotlight. (
  • At the same time, knowledge of the precise nasal anatomic variants is key in the preoperative evaluation of patients undergoing sinus surgery. (
  • As certain anatomic variants are considered as risk factors for sinus surgery, the study of the patient anatomy may contribute to improved surgical outcomes. (
  • An endoscopic sinus surgery was performed. (
  • Osguthorpe JD, Calcaterra TC (1979) Nasolacrimal obstruction after maxillary sinus and rhinoplastic surgery. (
  • Therefore, the OMU is the major target of surgery, such as functional endoscopic sinus surgery (FESS), to reduce episodes of recurrent sinusitis. (
  • Extended surgery, in this anatomic region, does not allow the gross total tumor resection en bloc with negative margins to be required by oncologic principles. (
  • These patients underwent clinical evaluation, followed by either transmaxillary or endonasal endoscopic sinus surgery and histopathological examination of the resected tissue. (
  • Paranasal sinus minor salivary gland neoplasms may cause obstructive sinusitis, epistaxis, and nasal obstruction. (
  • Surgical removal is done if they extend beyond the boundaries of the sinus, continue to enlarge, are localized in the region adjacent to the nasofrontal duct, or if signs of chronic sinusitis are present and, regardless of size, in symptomatic tumors. (
  • More frequently they may impair normal drainage of one or more paranasal sinuses thereby resulting in acute or chronic sinusitis or even mucocele formation 1,3 . (
  • A benign neoplasm that arises from the ciliated respiratory mucosa that lines the nasal cavity or paranasal sinuses. (
  • They arise from the ectodermally derived Scheiderian mucosa that lines the nasal cavity and paranasal sinuses. (
  • ENB account for 1 to 5% of malignant neoplasm of the nasal cavity. (
  • NCI: A benign or malignant neoplasm affecting one of the following areas: base of skull and facial bones, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature and lymph nodes draining these areas. (
  • A primary or metastatic malignant neoplasm affecting the head and neck. (
  • Inverted papilloma of the nasal vault and paranasal sinuses: spectrum of CT findings. (
  • 4 ] A subgroup has shown that paranasal sinus and nasal cavity SCCs are associated with human papilloma virus (HPV) infection and that HPV-positive patients may have a better prognosis than those who are HPV negative. (
  • Recently, we experienced a case of oncocytic Schneiderian papilloma of the left maxillary sinus developed in 53-year-old female patient. (
  • Waidyasekara P, Sevilla MA, Shakeel M, Ahmad Z (2015) Bilateral Inverted Papilloma of Maxillary and Ethmoid Sinuses with Multiple Recurrences. (
  • The department in an ENT-hospital provides specialized and highly specialized care for patients with acute and chronic pathology of the pharynx, larynx, nasal cavity and paranasal sinuses, external, middle and inner ear. (
  • In 81.4% nasal cavity and in 15.9% maxillary sinus were original site of tumor. (
  • Parapharyngeal space salivary neoplasms often are diagnosed late in their evolution given lack of presenting symptoms until a large tumor size has been attained. (
  • Most commonly involved was the frontal sinus (11 cases, including a giant tumor comprising both frontal sinuses and 2 osteomas penetrating to the orbit), followed by ethmoid cells (3) and maxillary sinuses (2). (
  • Osteoma of the paranasal sinuses is a common benign tumor, usually found incidentally. (
  • CT and MRI ( Fig 1 ) demonstrated that the tumor filled the entire nasal cavity, ethmoid sinuses, sphenoid sinus, and left frontal sinus. (
  • Also searched for Neoplasm , Mouth Neoplasm , Tumor and more. (
  • As in ourpatient, a primary chordoma of the nasal cavity or paranasal sinuses may present with symptoms related to mechanical obstruction secondary to the tumor mass. (
  • However, in the English literature, this type of lesion tends to be referred to as hemangioma of the maxillary sinus, organized hematoma of the maxillary sinus, or organized hematoma of the maxillary sinus mimicking tumor [ 1 - 8 ]. (
  • MR imaging of normal nasal cycle: comparison with sinus pathology. (
  • It is more common for SN pathology to affect the orbit than the reverse, and primary sinus pathology may initially present with predominantly orbital, rather than sinus, symptomatology. (
  • Non-traumatic cerebrospinal fluid rhinorrhea caused by ethmoid sinus osteoma. (
  • The authors' holistic approach ensures coverage of the surgical management principles that pathologists must understand, particularly when called upon to diagnose odontogenic tumors and cysts, as well as benign and malignant salivary gland neoplasms. (
  • There are certain recurring patterns of inflammatory sinus disease that may be seen on sinus computed tomography (CT). (
  • The method used is to determine the presence of CB, paranasal sinus computed tomography (PNSCT) scans of 45 patients (25 females, 20 males) with AR were examined. (
  • Allergic rhinitis, concha bullosa, paranasal sinus computed tomography (PNSCT). (
  • Computed tomography (CT) of the paranasal sinuses revealed a large soft-tissue mass filling the entire right nasal cavity. (
  • Computed tomography (CT) is the workhorse modality in paranasal imaging. (
  • A computed tomography (CT) scan revealed a destructive soft-tissue mass in the left ethmoid sinus with invasion of the left orbit and compression of the medial rectus muscle. (
  • Malignant sinus mucosal melanoma is a rare neoplasm occurring in the head and neck regions, with poor prognosis. (
  • Mucoceles are slowly growing but expansive lesions that usually originate in the frontal sinuses. (
  • Nonneoplastic hemorrhagic lesions causing mucosal swelling and bone destruction can develop in the maxillary sinus. (
  • Infection then spreads to the paranasal sinuses, then to the orbit and cranial cavity. (
  • Intraoperatively, we observed that the left orbit had been invaded and the posterior wail of the frontal sinus had been eroded, but the dura mater was intact. (
  • A case of alveolar rhabdomyosarcoma of the ethmoid sinus invading the orbit in an adult. (
  • Cancer of the nasal cavity and paranasal sinuses is rare. (
  • What Happens After Treatment For Nasal Cavity or Paranasal Sinus Cancer? (
  • What Should You Ask Your Doctor about Nasal Cavity or Paranasal Sinus Cancer? (
  • What's New in Nasal Cavity and Paranasal Sinus Cancer Research and Treatment? (
  • Some data indicate that various industrial exposures may be related to cancer of the paranasal sinus and nasal cavity. (
  • Both primary and environmental tobacco smoke are related to increases in nasal and sinus cancer. (
  • Tobacco smoking and ETS are associated with significant nasal and sinus disease and cancer. (
  • Tumors or cancer of the PARANASAL SINUSES. (
  • However, ever use of barbiturates without a prescription (OR=4.9, 95%CI 1.7-13.8), working with or around cutting oils on a job (OR=1.9, 95%CI 1.1-3.1) and ever having had sinus infections (OR=2.3, 95%CI 1.1-4.6) were associated with nasopharyngeal cancer only. (
  • Johns ME, Kaplan MJ: Advances in the management of paranasal sinus tumors. (
  • The aim of the study was to evaluate the clinical outcome of intensity modulated radiotherapy (IMRT) in 46 patients with paranasal sinus tumors with special respect to treatment-related toxicity. (
  • To understand the pathogenesis and imaging appearances of rhinosinusitis and other pathological processes that may affect the paranasal sinuses, a brief review of sinus development and anatomy as it pertains to mucociliary clearance is essential. (
  • Our otorhinolaryngologists are skilled in the endoscopic repair of CSF leaks and have developed strategies for the minimally invasive endoscopic management of both benign and malignant neoplasms of the paranasal sinuses and skull base. (
  • The current study presents a retrospective review of all patients with paranasal and skull base tumors who developed nasolacrimal duct blockage after ablative maxillectomy with or without radiotherapy and/or chemotherapy and underwent endonasal endoscopic DCR between January 2006 and October 2012 in a tertiary reference medical center. (
  • In conclusion, endonasal endoscopic DCR in patients with paranasal and skull base tumors, who previously underwent maxillectomy, is generally successful and not associated with a high rate of complications or failure. (
  • Background: Osteomas are relatively common, benign, slow-growing, often asymptomatic neoplasms of the paranasal sinuses occurring mainly in the frontal and ethmoid sinuses. (
  • Tumors of the ethmoid sinuses, nasal vestibule, and nasal cavity are less common, and tumors of the sphenoid and frontal sinuses are rare. (
  • Less commonly these can arise at the sphenoid and frontal sinuses. (
  • The anterior sinuses include the frontal, maxillary and anterior ethmoid air cells (Figure 1), and the posterior ethmoid and sphenoid sinuses make up the posterior sinuses (Figure 2). (
  • 1) This neoplasm has a multifactorial etiology, although a significant relationship was found between several carcinogens in the air, such as tobacco smoke, and increasing incidence of this type of neoplasm. (
  • The most common site of occurrence of IP is at the lateral nasal wall and maxillary sinus, followed by ethmoid air cells and nasal septum. (
  • The cancers grow within the bony confines of the sinuses and are often asymptomatic until they erode and invade adjacent structures. (
  • 5) Mucoceles are believed to develop secondary to the obstruction of the sinus ostium. (
  • 3 Brinton LA, Blot WJ, Becker JA, Winn DM, Browder JP, Farmer JC Jr, Fraumeni JF Jr. A case-control study of cancers of the nasal cavity and paranasal sinuses. (
  • 3) It is estimated that 60%-70% of cancers of the nasal cavity occur in the maxillary sinus, as seen in our case. (
  • There are no significant sinus symptoms-hence the "silent" nature of the syndrome. (
  • In those patients with allergies, nasal and sinus symptoms may be exacerbated by tobacco smoking. (