A mixture of solid hydrocarbons obtained from petroleum. It has a wide range of uses including as a stiffening agent in ointments, as a lubricant, and as a topical anti-inflammatory. It is also commonly used as an embedding material in histology.
The infiltrating of tissue specimens with paraffin, as a supporting substance, to prepare for sectioning with a microtome.
The technique of using FIXATIVES in the preparation of cytologic, histologic, or pathologic specimens for the purpose of maintaining the existing form and structure of all the constituent elements.
A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
Agents employed in the preparation of histologic or pathologic specimens for the purpose of maintaining the existing form and structure of all of the constituent elements. Great numbers of different agents are used; some are also decalcifying and hardening agents. They must quickly kill and coagulate living tissue.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Thinly cut sections of frozen tissue specimens prepared with a cryostat or freezing microtome.
The technique of using a microtome to cut thin or ultrathin sections of tissues embedded in a supporting substance. The microtome is an instrument that hold a steel, glass or diamond knife in clamps at an angle to the blocks of prepared tissues, which it cuts in sections of equal thickness.
The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.
A refined petroleum fraction used as a fuel as well as a solvent.
A plastic substance deposited by insects or obtained from plants. Waxes are esters of various fatty acids with higher, usually monohydric alcohols. The wax of pharmacy is principally yellow wax (beeswax), the material of which honeycomb is made. It consists chiefly of cerotic acid and myricin and is used in making ointments, cerates, etc. (Dorland, 27th ed)
The process by which a tissue or aggregate of cells is kept alive outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
The infiltrating of histological specimens with plastics, including acrylic resins, epoxy resins and polyethylene glycol, for support of the tissues in preparation for sectioning with a microtome.
Methods of preparing cells or tissues for examination and study of their origin, structure, function, or pathology. The methods include preservation, fixation, sectioning, staining, replica, or other technique to allow for viewing using a microscope.
A mixture of liquid hydrocarbons obtained from petroleum. It is used as laxative, lubricant, ointment base, and emollient.
The technique of placing cells or tissue in a supporting medium so that thin sections can be cut using a microtome. The medium can be paraffin wax (PARAFFIN EMBEDDING) or plastics (PLASTIC EMBEDDING) such as epoxy resins.
Removal of minerals from bones during bone examination.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
A dye obtained from the heartwood of logwood (Haematoxylon campechianum Linn., Leguminosae) used as a stain in microscopy and in the manufacture of ink.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
The chromosome region which is active in nucleolus formation and which functions in the synthesis of ribosomal RNA.
Antibodies produced by a single clone of cells.
Pneumonia due to aspiration or inhalation of various oily or fatty substances.
Unctuous combustible substances that are liquid or easily liquefiable on warming, and are soluble in ether but insoluble in water. Such substances, depending on their origin, are classified as animal, mineral, or vegetable oils. Depending on their behavior on heating, they are volatile or fixed. (Dorland, 28th ed)
DNA present in neoplastic tissue.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
A round-to-oval mass of lymphoid tissue embedded in the lateral wall of the PHARYNX. There is one on each side of the oropharynx in the fauces between the anterior and posterior pillars of the SOFT PALATE.
A versatile red dye used in cosmetics, pharmaceuticals, textiles, etc., and as tissue stain, vital stain, and counterstain with HEMATOXYLIN. It is also used in special culture media.
Tumors or cancer of the human BREAST.
A subspecialty of pathology concerned with the molecular basis (e.g., mutations) of various diseases.
The use of silver, usually silver nitrate, as a reagent for producing contrast or coloration in tissue specimens.
A malignant epithelial tumor with a glandular organization.
The degree of replication of the chromosome set in the karyotype.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Centers for acquiring, characterizing, and storing organs or tissue for future use.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
That portion of the electromagnetic spectrum from the UHF (ultrahigh frequency) radio waves and extending into the INFRARED RAYS frequencies.
A benign neoplasm composed of glandular and fibrous tissues, with a relatively large proportion of glands. (Stedman, 25th ed)
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide. A cardenolide which is the aglycon of digoxin. Can be obtained by hydrolysis of digoxin or from Digitalis orientalis L. and Digitalis lanata Ehrh.
A histochemical technique for staining carbohydrates. It is based on PERIODIC ACID oxidation of a substance containing adjacent hydroxyl groups. The resulting aldehydes react with Schiff reagent to form a colored product.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.
The induction of local hyperthermia by either short radio waves or high-frequency sound waves.
The study of the structure of various TISSUES of organisms on a microscopic level.
DNA probes specific for the identification of human papilloma virus.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
A type I keratin that is found associated with the KERATIN-4 in the internal stratified EPITHELIUM. Defects in gene for keratin 13 cause HEREDITARY MUCOSAL LEUKOKERATOSIS.
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.

Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. (1/216)

The tumor suppressor gene PTEN/MMAC-1/TEP-1 (referred to hereafter as PTEN) maps to chromosome 10q23 and encodes a dual specificity phosphatase. The PTEN protein negatively regulates cell migration and cell survival and induces a G1 cell cycle block via negative regulation of the phosphatidylinositol 3'-kinase/protein kinase B/Akt signaling pathway. PTEN is frequently mutated or deleted in both prostate cancer cell lines and primary prostate cancers. A murine polyclonal antiserum was raised against a glutathione S-transferase fusion polypeptide of the COOH terninus of PTEN. Archival paraffin tissue sections from 109 cases of resected prostate cancer were immunostained with the antiserum, using DU145 and PC-3 cells as positive and negative controls, respectively. PTEN expression was seen in the secretory cells. Cases were considered positive when granular cytoplasmic staining was seen in all tumor cells, mixed when areas of both positive and negative tumor cell clones were seen, and negative when adjacent benign prostate tissue but not tumor tissue showed positive staining. Seventeen cases (15.6%) of prostate cancer were positive, 70 cases (64.2%) were mixed, and 22 cases (20.2%) were negative. Total absence of PTEN expression correlated with the Gleason score (P = 0.0081) and correlated more significantly with a Gleason score of 7 or higher (P = 0.0004) and with advanced pathological stage (American Joint Committee on Cancer stages T3b and T4; P = 0.0078). Thus, loss of PTEN protein is correlated with pathological markers of poor prognosis in prostate cancer.  (+info)

Recovery of ranavirus dsDNA from formalin-fixed archival material. (2/216)

The extraction and amplification of nucleic acid from formalin-fixed and paraffin-embedded tissues has become an important exercise in the collection of retrospective epidemiological data. A protocol is described that enables the extraction and amplification of dsDNA from fixed tissues within paraffin blocks and from specimens stored in 10% (aq) formalin. The procedure can be used for the examination of ranavirus DNA within archival tissues thereby providing valuable data for identifying the origin and tracing the spread of ranaviruses.  (+info)

Relation between antigen release and immune response of oil adjuvanted vaccines in chickens. (3/216)

The relationship between release properties of the model antigen, bovine serum albumin (BSA), from formulations in vitro and immune response after administration of various oil adjuvanted vaccines containing liquid paraffin was examined in chickens. The vaccine prepared at an hydrophile-lipophile-balance (HLB) number of 4.8 showed slower release of BSA and higher immune response on injected chickens than that with an HLB number of 6.0. Decreases of aqueous volume ratio in the formulation also led to slower release of BSA and higher immune response. The slower release rate of BSA showed higher ELISA antibody titer even at 20 weeks after vaccination. The ELISA antibody titer inversely was related to the constant release rate, k, calculated from the in vitro release test. The correlation coefficient was 0.863. The immune response of oil adjuvanted vaccines containing Haemophilus paragallinarum agreed well with these results with BSA. Our results indicated that a stronger and more prolonged immune response of oil adjuvanted vaccines was achieved by slower release rate of antigen from the formulation. In addition, there was a good correlation between immune response and the value of k.  (+info)

Immunofluorescent detection of alpha1-antitrypsin in paraffin embedded liver tissue. (4/216)

Alpha1-antitrypsin was detected by indirect immunofluorescence in frozen sections of liver biopsies from patients with clinically and biochemically proven alpha1-antitrypsin deficiency. The antigen could also be demonstrated in those liver specimens of the same patients which were fixed in Bouin's fluid and embedded in paraffin. The cellular localization and the brightness of the fluorescence were the same in both frozen and paraffin sections. Four additional biopsies from three other patients were selected on the basis of PAS-positive diastase-resistant inclusions reported in the hepatocytes. All these biopsies showed bright fluorescence in the cytoplasm of the liver cells although one of the biopsies was stored for as long as eight years. Specific fluorescence was constantly found in the periportal hepatocytes with varying degrees of positivity. No fluorescence was observed in the six control biopsies from patients with various other liver diseases. These findings prove that paraffin embedded specimens are suitable for immunofluorescence detection of alpha1-antitrypsin and that a retrospective study on old paraffin blocks is possible.  (+info)

Cutaneous necrosis due to cetrimide application. (5/216)

Reports of necrosis caused by quaternary ammonium compounds, such as cetrimide, are rare. The case is reported of a 77-year-old woman who was admitted to hospital for four months with cutaneous necrosis of the left foot and leg owing to the topical application of cetrimide powder.  (+info)

Congenital-infantile fibrosarcoma. A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues. (6/216)

Congenital-infantile fibrosarcoma (CIFS) is a relatively indolent sarcoma that should be distinguished from more aggressive spindle cell sarcomas of childhood. CIFSs have been found to have a novel recurrent reciprocal translocation t(12;15)(p13;q25) resulting in the gene fusion ETV6-NTRK3 (ETS variant gene 6; neurotrophic tyrosine kinase receptor type 3). We studied immunohistochemical expression of NTRK3, and conducted a reverse transcription-polymerase chain reaction (RT-PCR) assay to detect the ETV6-NTRK3 fusion transcripts using archival formalin-fixed paraffin-embedded tissues from 10 CIFSs. Thirty-eight other spindle cell tumors were included as controls. The ETV6-NTRK3 fusion transcripts were identified in 7 (70%) of 10 CIFSs. Nucleotide sequence analysis showed that the fusion occurred between ETV6 exon 5 and NTRK3 exon 13. The 38 control tumors were negative for the fusion transcript. Immunohistochemically, CIFSs consistently expressed NTRK3. But the expression of NTRK3 also was observed in 22 of 38 control tumors. These results show the diagnostic usefulness of RT-PCR methods to detect ETV6-NTRK3 fusion transcripts in archival formalin-fixed paraffin-embedded tissue and the important role of NTRK3 in the development of CIFS, despite its being a protein of little importance in differential diagnosis.  (+info)

Increasing the number of synapses modifies olfactory perception in Drosophila. (7/216)

The Drosophila mutant gigas produces an enlargement of postmitotic cells caused by additional rounds of DNA replication. In neurons, the mutant cell establishes more synapses than normal. We have taken advantage of this feature to study the effect of synapse number on odorant perception. Mosaic adults were generated in which one antenna was homozygous for gigas, whereas the contralateral side served as an internal control. Morphological analysis indicates that the number and type of sensory afferents forming the mutant antenna, as well as their projection to the olfactory glomeruli, are normal. In contrast, the volume of identified glomeruli increases to a variable extent, and mutant sensory neurons branch profusely. The number of synapses, estimated in the ventral (V) glomerulus that receives ipsilateral afferents only, is increased twofold to threefold. Large-dense-core vesicle-containing terminals that probably modulate olfactory centers are identified in the V glomerulus. Their number and size are not modified by the mutant input. Sensory transduction, measured by electroantennograms, is normal in amplitude and kinetics. In odorant tests, however, the profile of the behavioral response to ethyl acetate shows attractive responses to concentrations to which sibling controls remain indifferent (10(-)8 and 10(-)7 v/v). In addition, the intensity of the response is augmented both at attractive and repulsive odorant concentrations with respect to that of controls. These results demonstrate that increased synapse number in the sensory neurons can modify the behavior of the organism, allowing a higher sensitivity of perception.  (+info)

Cyclin D1 overexpression in multiple myeloma. A morphologic, immunohistochemical, and in situ hybridization study of 71 paraffin-embedded bone marrow biopsy specimens. (8/216)

Cyclin D1 expression was evaluated by immunohistochemical analysis and biotin-labeled in situ hybridization (ISH) in a series of 71 decalcified, paraffin-embedded bone marrow biopsy specimens from patients with multiple myeloma (MM). Cyclin D1 messenger RNA (mRNA) overexpression was detected by ISH in 23 (32%) of 71 cases, whereas cyclin D1 protein was identified by immunohistochemical analysis in 17 (24%) of 71 specimens. All cases that were positive by immunohistochemical analysis also were positive by ISH. Statistically significant associations were found between cyclin D1 overexpression and grade of plasma cell differentiation and between cyclin D1 overexpression and extent of bone marrow infiltration. Our findings demonstrate the following: (1) ISH for cyclin D1 mRNA is a sensitive method for the evaluation of cyclin D1 overexpression in paraffin-embedded bone marrow biopsy specimens with MM. (2) ISH is more sensitive than immunohistochemical analysis in the assessment of cyclin D1 expression. (3) Cyclin D1 overexpression in MM is correlated positively with higher histologic grade and stage.  (+info)

The symptoms of lipid pneumonia can be similar to those of other types of pneumonia, such as cough, fever, chills, and difficulty breathing. However, lipid pneumonia may also cause a distinctive "fatty" or "oily" appearance on chest X-rays.

There are several possible causes of lipid pneumonia, including inhalation of lipids from the environment or from certain medical procedures (such as intratracheal lipid injections), and certain underlying medical conditions (such as cystic fibrosis). The diagnosis of lipid pneumonia is typically made through a combination of clinical evaluation, chest X-rays, and laboratory tests.

Treatment of lipid pneumonia usually involves supportive care measures such as oxygen therapy, hydration, and pain management, as well as antibiotics to prevent or treat any underlying bacterial infections. In severe cases, hospitalization may be necessary to monitor and treat the condition.

Prognosis for lipid pneumonia is generally good if treated promptly and effectively, but the condition can be serious and potentially life-threatening if left untreated or if there are underlying medical conditions that complicate treatment.

There are different types of Breast Neoplasms such as:

1. Fibroadenomas: These are benign tumors that are made up of glandular and fibrous tissues. They are usually small and round, with a smooth surface, and can be moved easily under the skin.

2. Cysts: These are fluid-filled sacs that can develop in both breast tissue and milk ducts. They are usually benign and can disappear on their own or be drained surgically.

3. Ductal Carcinoma In Situ (DCIS): This is a precancerous condition where abnormal cells grow inside the milk ducts. If left untreated, it can progress to invasive breast cancer.

4. Invasive Ductal Carcinoma (IDC): This is the most common type of breast cancer and starts in the milk ducts but grows out of them and invades surrounding tissue.

5. Invasive Lobular Carcinoma (ILC): It originates in the milk-producing glands (lobules) and grows out of them, invading nearby tissue.

Breast Neoplasms can cause various symptoms such as a lump or thickening in the breast or underarm area, skin changes like redness or dimpling, change in size or shape of one or both breasts, discharge from the nipple, and changes in the texture or color of the skin.

Treatment options for Breast Neoplasms may include surgery such as lumpectomy, mastectomy, or breast-conserving surgery, radiation therapy which uses high-energy beams to kill cancer cells, chemotherapy using drugs to kill cancer cells, targeted therapy which uses drugs or other substances to identify and attack cancer cells while minimizing harm to normal cells, hormone therapy, immunotherapy, and clinical trials.

It is important to note that not all Breast Neoplasms are cancerous; some are benign (non-cancerous) tumors that do not spread or grow.

Adenocarcinoma is a term used to describe a variety of different types of cancer that arise in glandular tissue, including:

1. Colorectal adenocarcinoma (cancer of the colon or rectum)
2. Breast adenocarcinoma (cancer of the breast)
3. Prostate adenocarcinoma (cancer of the prostate gland)
4. Pancreatic adenocarcinoma (cancer of the pancreas)
5. Lung adenocarcinoma (cancer of the lung)
6. Thyroid adenocarcinoma (cancer of the thyroid gland)
7. Skin adenocarcinoma (cancer of the skin)

The symptoms of adenocarcinoma depend on the location of the cancer and can include:

1. Blood in the stool or urine
2. Abdominal pain or discomfort
3. Changes in bowel habits
4. Unusual vaginal bleeding (in the case of endometrial adenocarcinoma)
5. A lump or thickening in the breast or elsewhere
6. Weight loss
7. Fatigue
8. Coughing up blood (in the case of lung adenocarcinoma)

The diagnosis of adenocarcinoma is typically made through a combination of imaging tests, such as CT scans, MRI scans, and PET scans, and a biopsy, which involves removing a sample of tissue from the affected area and examining it under a microscope for cancer cells.

Treatment options for adenocarcinoma depend on the location of the cancer and can include:

1. Surgery to remove the tumor
2. Chemotherapy, which involves using drugs to kill cancer cells
3. Radiation therapy, which involves using high-energy X-rays or other particles to kill cancer cells
4. Targeted therapy, which involves using drugs that target specific molecules on cancer cells to kill them
5. Immunotherapy, which involves using drugs that stimulate the immune system to fight cancer cells.

The prognosis for adenocarcinoma is generally good if the cancer is detected and treated early, but it can be more challenging to treat if the cancer has spread to other parts of the body.

Adenofibromas are usually slow-growing and do not spread to other parts of the body. They may be small and firm or large and soft to the touch. They can be skin-colored or pink, and they may have a rough surface.

The cause of adenofibroma is not known, but it is thought to arise from abnormal growth of sweat gland cells. It is usually diagnosed by a dermatologist or a pathologist who examines a sample of the tumor under a microscope.

Treatment for adenofibroma is usually not necessary unless the tumor is causing symptoms or is cosmetically bothersome. In these cases, surgical removal of the tumor may be recommended. Complete removal of the tumor is usually possible, and the prognosis is excellent.

Sources:

* American Academy of Dermatology: Adenofibroma: Overview and Treatment Options
* Mayo Clinic: Adenofibroma: Symptoms and Causes
* Skin Cancer Foundation: Adenofibroma: Diagnosis and Treatment

SCC typically appears as a firm, flat, or raised bump on the skin, and may be pink, red, or scaly. The cancer cells are usually well-differentiated, meaning they resemble normal squamous cells, but they can grow rapidly and invade surrounding tissues if left untreated.

SCC is more common in fair-skinned individuals and those who spend a lot of time in the sun, as UV radiation can damage the skin cells and increase the risk of cancer. The cancer can also spread to other parts of the body, such as lymph nodes or organs, and can be life-threatening if not treated promptly and effectively.

Treatment for SCC usually involves surgery to remove the cancerous tissue, and may also include radiation therapy or chemotherapy to kill any remaining cancer cells. Early detection and treatment are important to improve outcomes for patients with SCC.

* Peripheral T-cell lymphoma (PTCL): This is a rare type of T-cell lymphoma that can develop in the skin, lymph nodes, or other organs.
* Cutaneous T-cell lymphoma (CTCL): This is a type of PTCL that affects the skin and can cause lesions, rashes, and other skin changes.
* Anaplastic large cell lymphoma (ALCL): This is a rare subtype of PTCL that can develop in the lymph nodes, spleen, or bone marrow.
* Adult T-cell leukemia/lymphoma (ATLL): This is a rare and aggressive subtype of PTCL that is caused by the human T-lymphotropic virus type 1 (HTLV-1).

Symptoms of T-cell lymphoma can include:

* Swollen lymph nodes
* Fever
* Fatigue
* Weight loss
* Night sweats
* Skin lesions or rashes

Treatment options for T-cell lymphoma depend on the subtype and stage of the cancer, but may include:

* Chemotherapy
* Radiation therapy
* Immunotherapy
* Targeted therapy

Prognosis for T-cell lymphoma varies depending on the subtype and stage of the cancer, but in general, the prognosis for PTCL is poorer than for other types of non-Hodgkin lymphoma. However, with prompt and appropriate treatment, many people with T-cell lymphoma can achieve long-term remission or even be cured.

The exact cause of ductal carcinoma is unknown, but certain risk factors such as family history, genetics, hormone replacement therapy, obesity, and delayed childbearing have been linked to its development. Early detection through mammography and breast self-examination can improve survival rates, which are generally high for women diagnosed with this type of cancer if caught early. Treatment typically involves surgery to remove the tumor (lumpectomy or mastectomy), followed by radiation therapy and/or chemotherapy.

... also called soft paraffin Tractor vaporizing oil, a fuel for petrol-paraffin engines "Paraffin" (song) the first single off the ... Paraffin oil (disambiguation) Paraffin test This disambiguation page lists articles associated with the title Paraffin. If an ... Paraffin may refer to: Paraffin wax, a white or colorless soft solid that is used as a lubricant and for other applications ... a fuel that is also known as paraffin Mineral oil, any of various colorless, odorless, light mixtures of alkanes in the C15 to ...
"Paraffin" (Red Snapper mix) (4:25) -Rankine, Walk "Paraffin" (single mix) (3:35) -Rankine, Walk "Paraffin" (Richard Fearless ... "Paraffin" is the first single by the trip hop/industrial band Ruby, from their debut album Salt Peter. It was released in the ... Dub) (8:05) -Rankine, Walk "Paraffin" (Harpie mix) (3:53) -Rankine, Walk "Heidi" (album version) (4:04) -Rankine, Walk total ...
The oxidation of paraffins was carried out in the liquid phase by molecular oxygen, e.g. by aerating with oxygen or atmospheric ... Paraffin oxidation enabled for first time the large-scale production of synthetic butter from coal by chemical means which was ... Paraffin oxidation is a historical industrial process for the production of synthetic fatty acids. The fatty acids are further ... The paraffin oxidation was almost exclusively run in a discontinuous batch mode. Fractions were selected based on the intended ...
Paraffin is unaffected by most common chemical reagents but burns readily. Its heat of combustion is 42 MJ/kg. Paraffin wax is ... Paraffin wax initially suffered from a low melting point. This was remedied by adding stearic acid. The production of paraffin ... Un-dyed, unscented paraffin candles are odorless and bluish-white. Paraffin wax was first created by Carl Reichenbach in ... Wikimedia Commons has media related to Paraffin wax. "Odd Uses of Paraffin", Scientific American, 13 July 1878, p. 19 (Articles ...
Paraffin at AllMusic Paraffin at Discogs (list of releases) (Articles with short description, Short description is different ... "Paraffin , FXCK RXP". Bandcamp. Retrieved June 1, 2019. Thompson, Paul A. (September 5, 2018). "Armand Hammer: Paraffin". ... Paraffin is the third studio album by American hip hop group Armand Hammer. It was released via Backwoodz Studioz in 2018. ... Nathan Stevens of Spectrum Culture gave the album a 4 out of 5, saying: "It's terrifyingly easy to get lost in Paraffin thanks ...
... may refer to: Liquid paraffin (drug) Mineral oil In chemistry, a mixture of heavier alkanes This disambiguation ... page lists articles associated with the title Liquid paraffin. If an internal link led you here, you may wish to change the ...
... may refer to: (in British English) paraffin, called kerosene in North American English (in North American English ... for example mineral oil This disambiguation page lists articles associated with the title Paraffin oil. If an internal link led ...
The grade of paraffin used is known as tractor vaporising oil in the UK. The advantages of the petrol-paraffin engine are that ... Paraffin is less volatile than petrol, and will not normally ignite at ambient temperatures, so the petrol-paraffin engine is ... A petrol/paraffin engine tends to run hotter whilst burning paraffin, and so the cooling system must be sufficiently robust. ... It was a 70 bhp petrol-paraffin engine, but using solid naphthalene rather than paraffin, simply as a cheaper fuel. The ...
Liquid paraffin, also known as paraffinum liquidum, paraffin oil, liquid paraffin oil or Russian mineral oil, is a very highly ... The generic sense of paraffin meaning alkane led to regional differences for the meanings of both paraffin and paraffin oil. It ... Cosmetic or medicinal liquid paraffin should not be confused with the paraffin (i.e. kerosene) used as a fuel. ... liquid paraffin gained more popularity. Liquid paraffin is primarily used as a pediatric laxative in medicine and is a popular ...
The Daimler Paraffin Railway was the first set of rolling stock with petrol engine. Three original vehicles for passenger and ... Petrol-paraffin engine Motor-Draisine. Thomas Winkler: Daimler Motorwagen. Josef Nagler: Blätter für Technikgeschichte, Band 22 ... Gottlieb Daimler demonstrated in 1887 on the Cannstatter Volksfest a paraffin driven narrow gauge railway. It was well received ... which used paraffin (kerosene) as fuel. It was the first piece of rolling stock with an internal combustion engine. It was ...
... are synthesized by reaction of chlorine gas with unbranched paraffin fractions (. ... Chlorinated paraffins (CPs) are complex mixtures of polychlorinated n-alkanes. The chlorination degree of CPs can vary between ...
Paraffin Safety Surveillance System Paraffin Safety Case Study WHO October 17-19, 2005 Paraffin Safety Welcomes the new Energy ... the Paraffin Safety Association is focussing on packaging standards to ensure paraffin is sold in clearly marked, childproof ... The Paraffin Safety Association of Southern Africa (also known as PASASA) is a non-profit organization that is dedicated to ... In 2003 the Paraffin Safety Association of Southern Africa decided to extend its interventions beyond the head office in Cape ...
paraffin 1. A trivial (non-IUPAC) name for any alkane. 2. Another name for kerosene. partial pressure partition coefficient ...
The company was also producing: condensing plants; air compressors; fan engines; pumping engines; paraffin engines. Having ...
No paraffin. Guinness good." In March 1942 the government banned the export of beers, and decided that more wheat should be ...
In particular, Paraffin can keep the GUIDs assigned to each file the same even when the tool is run multiple times. Paraffin ... There is also a third-party tool called Paraffin, available under the Common Public License, which offers several features not ... Robbins, John (14 November 2012). "Wintellect/Paraffin". GitHub. Retrieved 16 February 2014. Mensching, Rob (3 September 2012 ...
He later wrote to The Morning Post about the safety standards of paraffin lamps. At an inquest on a boating accident at Kew in ... "PARAFFIN LAMP FATALITIES". St James's Gazette. 13 March 1897 - via British Newspaper Archive. "PETROLEUM LAMP ACCIDENTS". ... Society wanted restrictions on the sale of cheap and dangerous paraffin lamps. ...
In 2018, the duo released a studio album, Paraffin. PopMatters placed it at number 65 on the "70 Best Albums of 2018" list, ... Armand Hammer - Paraffin (Backwoodz Studioz)". PopMatters. Archived from the original on December 21, 2018. Retrieved December ... Thompson, Paul A. (September 5, 2018). "Armand Hammer: Paraffin". Pitchfork. Archived from the original on December 19, 2018. ... Billy Woods - vocals Elucid - vocals, production Race Music (2013) Rome (2017) Paraffin (2018) Shrines (2020) Haram (2021) ( ...
The Paraffin Series". Proceedings of the Royal Society of London A: Mathematical, Physical and Engineering Sciences. 100 (707 ...
The paraffin series". Proceedings of the Royal Society of London. Series A, Containing Papers of a Mathematical and Physical ...
Thompson, Paul A. (September 5, 2018). "Armand Hammer: Paraffin". Pitchfork. Retrieved January 11, 2021. Blum, Jordan (July 9, ...
Defiance MK III's engine, QUASAR, is a Nitrous-Paraffin hybrid engine, capable of producing 7 kN of thrust for a period of 9 ... Stratos II+ was propelled by the DHX-200 hybrid rocket engine, using a nitrous oxide oxidizer and fuel blend of paraffin, ... University of Brasilia's Hybrid Team has extensive research in paraffin wax / N2O hybrids having already made more than 50 ... "Developing and testing of a 2 kN hybrid rocket engine". hybrid-engine-development.de (in German). "Paraffin hybrid links". ...
Paraffin, herbal baths, massage; Magneto-diaflux, ionization medical gymnastics; Internal treatment with mineral water, manual ...
Around 1900, surgeons tried injecting paraffin into the lips without success. Liquid silicone was used for lip augmentation, ... "Histopathology of paraffin prosthesis". J Cutan Dis. 24: 513-521. Duffy, D. (1998). "Injectable liquid silicone: New ...
"Paraffin - Family 1-l". Thoroughbred Bloodlines. Retrieved 30 May 2012. "Prix de la Sorbonne result". Racing Post. 3 September ...
The Normal Paraffin Hydrocarbons.,doi=10.1021/ja00905a004,url=http://pubs.acs.org/doi/abs/10.1021/ja00905a004 (Articles with ...
ISBN 0-354-08536-0. "Paraffin - Family 1-l". Thoroughbred Bloodlines. Retrieved 2012-05-30. "England's Classics". paperspast. ...
The most common contaminants are: water; solid particles; gases; asphalt-resinous paraffin deposits; acids; oil sludge; ...
"Paraffin - Family 1-l". Thoroughbred Bloodlines. Retrieved 2012-05-30. "Prix de Fontenoy result". Racing Post. 1 September 2019 ...
"Paraffin - Family 1-l". Thoroughbred Bloodlines. Retrieved 30 May 2012. "Drivers Jonas Won't Wait Furlong Handicap result". ...
OSHA previously had no limit for paraffin wax fume and proposed establishing an 8-hour TWA limit of 2 mg/m3; NIOSH concurred ... Paraffin is considered nontoxic in its solid state, but fume generated when it is in the molten state may cause discomfort and ... OSHA previously had no limit for paraffin wax fume and proposed establishing an 8-hour TWA limit of 2 mg/m3; NIOSH (Ex. 8-47, ... OSHA is more concerned about workplaces in which paraffin is used in large quantities, such as the food industry, and a greater ...
This article discusses what may occur if you swallow or eat paraffin. ... Paraffin is a solid waxy substance used to make candles and other items. ... If the paraffin contains a dye, a person who has an allergy to that dye may develop tongue and throat swelling, wheezing, and ... Paraffin is a solid waxy substance used to make candles and other items. This article discusses what may occur if you swallow ...
Chlorinated paraffins  Kenne, K; Ahlborg, U. G; World Health Organization (‎World Health OrganizationWorld Health Organization ...
... fixed with formaldehyde and embedded in paraffin). Although the extra … ... Purification of DNA from formaldehyde fixed and paraffin embedded human tissue Biochem Biophys Res Commun. 1985 Jul 16;130(1): ... fixed with formaldehyde and embedded in paraffin). Although the extracted DNA is not intact, it is double stranded, cleavable ...
BsmI incubations should be done at 65°C under paraffin oil in a capped vial. ... Home FAQs Should BsmI digests be performed under paraffin oil? FAQ: Should BsmI digests be performed under paraffin oil?. Yes. ... BsmI incubations should be done at 65°C under paraffin oil in a capped vial. Links to this resource. Related Products:. BsmI. ...
Visit CellSignal.com to view our IHC-paraffin materials including Immunohistochemisty, Miscroscopy & more. CST - Customer ... IF-paraffin (11) IHC Leica Bond (386) IHC-paraffin (1793) Immunofluorescence (Immunocytochemistry) (2238) Immunohistochemistry ...
... An excerpt from Sean Singers "Paraffin Fuel," originally published in NER 29.2 (2008): ... Filed Under: NER Classics Tagged With: Paraffin Fuel, Sean Singer. Previous post. New Books from NER Writers: BFI Film Classics ...
The goal of this proposed project is to develop novel high performance membranes that separate olefins from paraffins under ... The ethylene and propylene must be separated from their close-boiling paraffins, currently achieved using traditional low- ... which have strong size-sieving capabilities that can provide high olefin/paraffin selectivity. In Phase I, MTR will work with a ... Successful development of the proposed membranes could lead to bulk separation of the olefin/paraffin mixtures produced by ...
Testing Status of Chlorinated paraffins: C23, 43% chlorine 10062-P. Testing Status of Chlorinated paraffins: C23, 43% chlorine ... Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C23, 43Chlorine) (CASRN 108171-27-3) in F344/N Rats and B6C3F1 ... Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C23, 43Chlorine) (CASRN 108171-27-3) in F344/N Rats and B6C3F1 ...
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... paraffin oil) for synthesis; CAS Number: 7440-23-5; Synonyms: Sodium; find Sigma-Aldrich-822284 MSDS, related peer-reviewed ...
MS imaging of paraffin-embedded tissue sections of human endometrial cancer and ovarian cancer. After de-paraffinization and ... Similarly, paraffin-embedded tissue sections of human ovarian cancer were de-paraffinized, trypsin and DHB matrix added by CHIP ... enzyme treatment, MALDI-TOF MS imaging analysis is possible on paraffin-embedded tissue sections obtained from long-term ...
Novel Fixative for Improved Biomolecule Quality from Paraffin-Embedded Tissue (U.S. Patent Number 15/774,480). Tissues samples ... Novel Fixative for Improved Biomolecule Quality from Paraffin-Embedded Tissue (U.S. Patent Number 15/774,480) ... Before diagnosis, patient samples are typically processed by fixation and paraffin embedding. This fixation/embedding process ...
The Importance of Paraffin. Presented by Heather Renko-Breed, HT(ASCP)QIHC. ... This webinar will be an exploration of paraffin and what makes it so unique to the world of Histotechnology ...
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The global paraffins market is driven by its increasing application across construction and infrastructure industries such as ... oilfield chemicals, internal olefins, sulphonates, secondary alcohols, chlorinated paraffins, etc. ... Paraffin Market Size, Share, Trends, Global Industry Report, 2025 GVR Report cover Paraffins Market Size, Share & Trends ... Paraffins Market participants are carrying out R&D activities to explore new applications to increase paraffins demand over the ...
Improving gene expression analysis efficacy from formalin-fixed paraffin embedded tissues Pantelis Dimaras 1 , Oskan Tasinov 1 ... Improving gene expression analysis efficacy from formalin-fixed paraffin embedded tissues Pantelis Dimaras et al. Folia Med ( ... RNA expression analysis from formalin fixed paraffin embedded tissues. Farragher SM, Tanney A, Kennedy RD, Paul Harkin D. ... Aim: The aim of the study was to compare three modified methods for RNA extraction from formalin-fixed paraffin embedded (FFPE ...
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Paraffin Wax is multi-use wax that can be used in a variety of cosmetics and DIY products. It is a natural emollient that can ... Material: Paraffin.. Paraffin waxes come in various different melt points and grades.This particular wax is a good mid-range ... "Paraffin Wax is multi-use wax that can be used in a variety of cosmetics and DIY products. It is a natural emollient that can ... It is softer than your "store bought" paraffin that one might use for canning foods, and it also comes in a pastille form for ...
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  • The aim of the study was to compare three modified methods for RNA extraction from formalin-fixed paraffin embedded (FFPE) biopsied tissue and different cDNA synthesis strategies to facilitate study of gene expression. (nih.gov)
  • One obstacle to clinical translation is that these signatures were developed using frozen tissue, whereas usually only formalin-fixed, paraffin embedded (FFPE) tissue is available. (nih.gov)
  • Immunofluorescence is an indispensable method for the identification, localization and study of the expression of target antigens in formalin -fixed, paraffin -embedded (FFPE) tissue sections of human bone marrow . (bvsalud.org)
  • Use of archival resources has been limited to date by inconsistent methods for genomic profiling of degraded RNA from formalin-fixed paraffin-embedded (FFPE) samples. (nih.gov)
  • This paper compared RNA yields, purity, and fragment size as well as total RNA and exome next-generation sequencing (NGS) metrics among RNA extracted from sections of formalin-fixed paraffin-embedded (FFPE) diffuse large B-cell lymphoma (DLBCL) tumors using three different extraction kits. (nih.gov)
  • Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues. (nih.gov)
  • After de-paraffinization and enzyme treatment, MALDI-TOF MS imaging analysis is possible on paraffin-embedded tissue sections obtained from long-term storage at many hospitals and research organizations. (shimadzu.com)
  • Similarly, paraffin-embedded tissue sections of human ovarian cancer were de-paraffinized, trypsin and DHB matrix added by CHIP-1000, and MS/MS analysis performed using an AXIMA-QIT to directly identify the proteins in the sections. (shimadzu.com)
  • 16 watts/in 2 (2.5 watts/cm 2 )-Typical Applications: Medium Weight Oils, Heat Transfer Oils, Liquid Paraffin. (omega.com)
  • The goal of this proposed project is to develop novel high performance membranes that separate olefins from paraffins under industrial conditions (hydrocarbon pressures up to saturation levels and temperatures of 60-120C). (sbir.gov)
  • Rising demand in various end-use industries such as internal olefins, secondary alcohols, sulphonates, chlorinated paraffins, oilfield chemicals , etc., is also expected to propel the market over forecast period. (grandviewresearch.com)
  • Paraffin is considered nontoxic in its solid state, but fume generated when it is in the molten state may cause discomfort and nausea (Queries and Minor Notes, JAMA 1938/ Ex. (cdc.gov)
  • Paraffin is usually nontoxic (not harmful) if swallowed in small amounts. (medlineplus.gov)
  • A simple quantitative diagnostic alternative for MGMT DNA-methylation testing on RCL2 fixed paraffin embedded tumors using restriction coupled qPCR. (bvsalud.org)
  • He also reported that a literature search dating back to 1965 produced no references on the toxicology of paraffin wax fume. (cdc.gov)
  • 1-3, p. 455) report acute adverse effects associated with the use of molten paraffin. (cdc.gov)
  • To protect employees in these industries from experiencing acute adverse effects, such as discomfort and nausea, OSHA believes that a PEL for paraffin wax fume is necessary. (cdc.gov)
  • The Agency has determined that the adverse effects associated with excessive exposure to paraffin wax fume constitute material impairments of health. (cdc.gov)
  • Paraffin is used mainly in candle manufacturing along with explosives, grafts, and cork stopper production. (grandviewresearch.com)
  • Eating a lot of paraffin can lead to intestinal obstruction, which can cause abdominal pain, nausea, vomiting, and possible constipation. (medlineplus.gov)
  • Paraffins may be affected by volatile raw material prices over the forecast period, being a by-product of crude oil. (grandviewresearch.com)
  • Material: Paraffin. (tkbtrading.com)
  • Material and Method: Paraffin-embedded blocks from 30 patients with oropharynx squamous cell carcinomas, diagnosed and treated at the Oral Oncology Center were selected. (bvsalud.org)
  • Paraffin Wax is multi-use wax that can be used in a variety of cosmetics and DIY products. (tkbtrading.com)
  • Market players are executing various marketing techniques and promotional activities to make the product popular in end-use industries which in turn are expected to boost paraffins demand. (grandviewresearch.com)
  • Intensive product promotion in order to tap Middle East and African markets is also projected to drive the paraffins industry along with growing developmental activities in these nations. (grandviewresearch.com)
  • A complete process design to integrate the membrane process with olefin production or recovery process trains will be developed based on the field test data, along with a commercialization plan.Commercial Applications and Other Benefits: Successful development of the proposed membranes could lead to bulk separation of the olefin/paraffin mixtures produced by steam cracking, which could substantially cut the energy consumption and reduce the cost of olefin production. (sbir.gov)
  • Conclusion: Dilution of the DNA extracted of paraffin-embedded materials did not modify statistically the amount of positive samples β-globin gene amplified in PCR, although the results suggest that this is a way to increase the method for efficacy amplification of PCR. (bvsalud.org)
  • Increasing applications in the rubber industry as an additive for tire production, to avoid the occurrence of cracks is also expected to drive the paraffins industry. (grandviewresearch.com)
  • Demand from the food industry in surface protection applications to promote freshness is also anticipated to have a positive impact on paraffins demand. (grandviewresearch.com)
  • It has significant applications in farming, packaging, lighting, chemicals, medical and rubber industries which may also have a positive impact on the paraffin market. (grandviewresearch.com)
  • North America is expected to witness the largest paraffins demand over the forecast period followed by Europe, owing to increasing applications in the infrastructure and construction industry. (grandviewresearch.com)
  • Paraffins Market participants are carrying out R&D activities to explore new applications to increase paraffins demand over the coming seven years. (grandviewresearch.com)
  • Details for: Chlorinated paraffins. (who.int)
  • In the most recent report of industrial exposure effects, paraffin fume is reported to cause no discomfort in most cases when the concentration is maintained at or below 2 mg/m 3 , although one instance of mild discomfort was reported at concentrations between 0.6 and 1 mg/m 3 (Massachusetts Division of Occupational Hygiene 1970, as cited in ACGIH 1986/Ex. (cdc.gov)
  • OSHA also believes that promulgation of a PEL for paraffin wax fume will present little problem for pathology laboratories, since Dr. Zeiler commented that most clinical laboratories already comply with the ACGIH TLVs and that the services of certified industrial hygienists are used when new laboratories are designed or old ones are remodeled. (cdc.gov)
  • OSHA is more concerned about workplaces in which paraffin is used in large quantities, such as the food industry, and a greater degree of exposure control is needed. (cdc.gov)
  • Paraffin is a white or slightly yellow, odorless solid that is derived from petroleum. (cdc.gov)
  • In this report it is shown that DNA can be extracted from tissues prepared for routine histopathological examination (i.e., fixed with formaldehyde and embedded in paraffin). (nih.gov)
  • Multicolor Immunofluorescence Staining of Paraffin-Embedded Human Bone Marrow Sections. (bvsalud.org)
  • It is softer than your "store bought" paraffin that one might use for canning foods, and it also comes in a pastille form for easy measure and melting. (tkbtrading.com)
  • These membranes are based on newly discovered thermally rearranged (TR) polymers, which have strong size-sieving capabilities that can provide high olefin/paraffin selectivity. (sbir.gov)
  • The global paraffins market is expected to grow over the forecast period, owing to the increasing application as a sizing agent within expanding construction and infrastructure industries in emerging nations. (grandviewresearch.com)
  • Introduction: Several reasons may lead to the failure of polymerase chain reaction (PCR) using DNA purified from paraffin-embedded materials: presence of inhibitors and degradation of target DNA. (bvsalud.org)
  • Paraffin is a solid waxy substance used to make candles and other items. (medlineplus.gov)
  • The ethylene and propylene must be separated from their close-boiling paraffins, currently achieved using traditional low-temperature distillation, and energy and capital intensive process. (sbir.gov)
  • Paraffin is produced in the process of refining crude oil to gasoline. (grandviewresearch.com)
  • Paraffins is also utilized in the agriculture segment as an anti-caking additive to simplify the transportation and handling process of fertilizers. (grandviewresearch.com)
  • Before diagnosis, patient samples are typically processed by fixation and paraffin embedding. (nih.gov)