A family of small, non-enveloped DNA viruses, infecting mainly MAMMALS, and containing a single genus: POLYOMAVIRUS.
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
Deoxyribonucleic acid that makes up the genetic material of viruses.
Retroviruses that have integrated into the germline (PROVIRUSES) that have lost infectious capability but retained the capability to transpose.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).
Virus diseases caused by the RETROVIRIDAE.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Nucleotide sequences repeated on both the 5' and 3' ends of a sequence under consideration. For example, the hallmarks of a transposon are that it is flanked by inverted repeats on each end and the inverted repeats are flanked by direct repeats. The Delta element of Ty retrotransposons and LTRs (long terminal repeats) are examples of this concept.
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Indolesulfonic acid used as a dye in renal function testing for the detection of nitrates and chlorates, and in the testing of milk.
The systematic arrangement of entities in any field into categories classes based on common characteristics such as properties, morphology, subject matter, etc.
International collective of humanitarian organizations led by volunteers and guided by its Congressional Charter and the Fundamental Principles of the International Red Cross Movement, to provide relief to victims of disaster and help people prevent, prepare for, and respond to emergencies.
A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).
A plant genus of the family Paeoniaceae, order Dilleniales, subclass Dilleniidae, class Magnoliopsida. These perennial herbs are up to 2 m (6') tall. Leaves are alternate and are divided into three lobes, each lobe being further divided into three smaller lobes. The large flowers are symmetrical, bisexual, have 5 sepals, 5 petals (sometimes 10), and many stamens.
Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.
Pathological processes of the UTERINE CERVIX.
Tumors or cancer of the UTERINE CERVIX.
A type of ALPHAPAPILLOMAVIRUS especially associated with malignant tumors of the CERVIX and the RESPIRATORY MUCOSA.
Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
A type of human papillomavirus especially associated with malignant tumors of the genital and RESPIRATORY MUCOSA.
Traumatic injuries to the RECURRENT LARYNGEAL NERVE that may result in vocal cord dysfunction.
Endoscopic surgical procedures performed with visualization via video transmission. When real-time video is combined interactively with prior CT scans or MRI images, this is called image-guided surgery (see SURGERY, COMPUTER-ASSISTED).
Viruses whose genetic material is RNA.
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Anomaly of the tooth, found chiefly in upper lateral incisors. It is characterized by invagination of the enamel at the incisal edge.
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.

C-myc overexpression and p53 loss cooperate to promote genomic instability. (1/4848)

p53 monitors genomic integrity at the G1 and G2/M cell cycle checkpoints. Cells lacking p53 may show gene amplification as well as the polyploidy or aneuploidy typical of many tumors. The pathways through which this develops, however, are not well defined. We demonstrate here that the combination of p53 inactivation and c-myc overexpression in diploid cells markedly accelerates the spontaneous development of tetraploidy. This is not seen with either N-myc or L-myc. Tetraploidy is accompanied by significantly higher levels of cyclin B and its associated cdc2 kinase activity. Mitotic spindle poisons accelerate the appearance of tetraploidy in cells either lacking functional p53 or overexpressing c-myc whereas the combination is additive. Restoration of p53 function in cells overexpressing c-myc causing rapid apoptosis, indicating that cells yet to become tetraploid have nonetheless suffered irreversible genomic and/or mitotic spindle damage. In the face of normal p53 function, such damage would either be repaired or trigger apoptotis. We propose that loss of p53 and overexpression of c-myc permits the emergence and survival of cells with increasingly severe damage and the eventual development of tetraploidy.  (+info)

Hybrid capture II, a new sensitive test for human papillomavirus detection. Comparison with hybrid capture I and PCR results in cervical lesions. (2/4848)

AIM: To test a new assay for the detection of human papillomavirus (HPV) DNA, hybrid capture II (HC II), compared with the previous commercialized hybrid capture I (HC I) and polymerase chain reaction (PCR) results on cervical scrapes from fresh cone excision biopsy samples. METHODS: The three methods were used on cervical scrapes from 42 fresh cone excision biopsy samples. There were nine metaplastic and inflammatory lesions, five low grade lesions, and 28 high grade lesions. PCR was performed using the general primers GP5+/GP6+. The viral load of high risk HPV DNA was estimated by the ratio of relative light units to positive control values in the samples. RESULTS: The sensitivity of HC I for the detection of high grade lesions was 71.4%, while it was 92.8% for HC II and 96.4% for the PCR. Considering only the absence of detectable cervical in situ neoplasia, the specificity was 88.9% for HC I, 66.7% for HC II, and 66.7% for PCR. With HC II, for a ratio of cervical sample to normal control of > 200, the sensitivity for the detection of high grade lesion was only 34.6% with a specificity of 66.7%. CONCLUSIONS: HPV detection with the HC II assay is more sensitive than the previous HC I and represents a more convenient and easier test than PCR for routine use. Nevertheless the viral load estimated with this test cannot be a reliable predictive indicator of high grade lesions.  (+info)

Human papillomavirus DNA in adenosquamous carcinoma of the lung. (3/4848)

AIM: To investigate the presence of human papillomavirus (HPV) DNA in adenosquamous carcinoma of the lung--which is relatively common in Okinawa but not in mainland Japan--and examine its histological features. METHODS: Of 207 cases where primary lung cancers were surgically removed between January 1995 and June 1997 in Okinawa, 23 were adenosquamous carcinoma. HPV was detected by non-isotopic in situ hybridisation (NISH) and polymerase chain reaction (PCR) amplification with primers specific for E6 and E7 regions of the HPV genome. PCR products were analysed by Southern blotting. Immunohistochemical determination of high molecular weight cytokeratin (HMC) and involucrin was also carried out. RESULTS: 18 cases were positive for HPV DNA by PCR and NISH. HPV types 6, 11, 16, and 18 were found. Seven cases were dual positive for different types of HPV. Using NISH, HPV was also found in the squamous cell components and in neighbouring enlarged adenocarcinoma cells. The HMC and involucrin were demonstrated immunohistochemically in the same areas. CONCLUSIONS: HPV DNA was found in a high proportion (78.3%) of adenosquamous carcinomas in Okinawa, a region where HPV has previously been shown to be prevalent in squamous cell carcinoma of the lung. The adenocarcinoma cells adjacent to the squamous cell carcinoma component were enlarged and positive for HPV, HMC, and involucrin. This is thought to indicate the transition from adenocarcinoma to squamous cell carcinoma.  (+info)

Immunohistochemical expression of mdm2 and p21WAF1 in invasive cervical cancer: correlation with p53 protein and high risk HPV infection. (4/4848)

AIM: To investigate the immunocytochemical staining pattern of mdm2 and p21WAF1 proteins in invasive cervical cancer and to determine its relation with the expression of p53 and with the high risk HPV infection. METHODS: Immunocytochemistry for p53, mdm2, and p21WAF1 was performed in 31 paraffin embedded sections of invasive cervical cancer. The results were assessed by image analysis, evaluating for each protein the optical density of the immunostained area, scored as percentage of the total nuclear area. The presence of high risk human papillomavirus (HPV) infection was detected by using the polymerase chain reaction. RESULTS: Immunostaining for both mdm2 and p21WAF1 was correlated with p53 expression; however, the correlation between p53 and mdm2 (R = 0.49; p < 0.01) was more significant than between p53 and p21WAF1 (R = 0.31; p < 0.05); the less stringent correlation between p53 and p21WAF1 might reflect the p53 independent mechanisms of p21WAF1 induction. Similar average levels of p53, mdm2, and p21WAF1 immunostaining were found in the presence or absence of high risk HPV-DNA, without significant differences between the two groups. CONCLUSIONS: These data suggest that mdm2 and p21WAF1 proteins are expressed in invasive cervical cancer and that their immunocytochemical staining pattern is not abrogated by the presence of high risk HPV genomic sequences.  (+info)

Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding site. (5/4848)

The retinoblastoma susceptibility gene product (RB) is a transcriptional modulator. One of the targets for this modulator effect is the AP-1 binding site within the c-jun and collagenase promoters. The physical interactions between RB and c-Jun were demonstrated by co-immunoprecipitation of these two proteins using anti-c-Jun or anti-RB antisera, glutathione S-transferase affinity matrix binding assays in vitro, and electrophoretic mobility shift assays. The C-terminal site of the leucine zipper of c-Jun mediated the interaction with RB. Although the B-pocket domain of RB alone bound to c-Jun, a second c-Jun binding site in the RB was also suggested. Mammalian two-hybrid-based assay provided corroborative evidence that transactivation of gene expression by RB required the C-terminal region of c-Jun. We conclude that RB enhances transcription activity mediated through the AP-1 binding site. Adenovirus E1A or human papillomavirus E7 inhibits RB-mediated transcription activity. These data reveal that the interactions between these two distinct classes of oncoproteins RB and c-Jun may be involved in controlling cell growth and differentiation mediated by transcriptional regulation.  (+info)

The L1 major capsid protein of human papillomavirus type 11 recombinant virus-like particles interacts with heparin and cell-surface glycosaminoglycans on human keratinocytes. (6/4848)

The L1 major capsid protein of human papillomavirus (HPV) type 11, a 55-kDa polypeptide, forms particulate structures resembling native virus with an average particle diameter of 50-60 nm when expressed in the yeast Saccharomyces cerevisiae. We show in this report that these virus-like particles (VLPs) interact with heparin and with cell-surface glycosaminoglycans (GAGs) resembling heparin on keratinocytes and Chinese hamster ovary cells. The binding of VLPs to heparin is shown to exhibit an affinity comparable to that of other identified heparin-binding proteins. Immobilized heparin chromatography and surface plasmon resonance were used to show that this interaction can be specifically inhibited by free heparin and dextran sulfate and that the effectiveness of the inhibitor is related to its molecular weight and charge density. Sequence comparison of nine human L1 types revealed a conserved region of the carboxyl terminus containing clustered basic amino acids that bear resemblance to proposed heparin-binding motifs in unrelated proteins. Specific enzymatic cleavage of this region eliminated binding to both immobilized heparin and human keratinocyte (HaCaT) cells. Removal of heparan sulfate GAGs on keratinocytes by treatment with heparinase or heparitinase resulted in an 80-90% reduction of VLP binding, whereas treatment of cells with laminin, a substrate for alpha6 integrin receptors, provided minimal inhibition. Cells treated with chlorate or substituted beta-D-xylosides, resulting in undersulfation or secretion of GAG chains, also showed a reduced affinity for VLPs. Similarly, binding of VLPs to a Chinese hamster ovary cell mutant deficient in GAG synthesis was shown to be only 10% that observed for wild type cells. This report establishes for the first time that the carboxyl-terminal portion of HPV L1 interacts with heparin, and that this region appears to be crucial for interaction with the cell surface.  (+info)

Analysis of TSG101 tumour susceptibility gene transcripts in cervical and endometrial cancers. (7/4848)

Carcinoma of the uterine cervix is a common malignancy among women that has been found to show loss of heterozygosity in the chromosome 11p. Recent studies have localized the TSG101 gene in this region, and also demonstrated a high frequency of abnormalities of this gene in human breast cancer. To determine the role of the TSG101 gene in the carcinogenesis of cervical and uterine carcinoma, 19 cases of cervical carcinoma and five cases of endometrial carcinoma, as well as nearby non-cancerous tissue from the same patients, and 16 blood samples from healthy persons as normal control were analysed by Southern blot analysis of genomic DNA, reverse transcription of the TSG101 mRNA followed by PCR amplification and sequencing of the products. We found that abnormal transcripts of the TSG101 gene were common both in cancerous or non-cancerous tissues of the uterus and cervix and in normal peripheral mononuclear cells. There was no genomic deletion or rearrangement in spite of the presence of abnormal transcripts, and no definite relationship between the abnormal transcripts and HPV infection was found. Although the frequency of abnormal transcripts was higher in cancerous than in non-cancerous tissue, normal peripheral mononuclear cells also had abnormal transcripts. Given these findings, the role of the TSG101 gene as a tumour-suppressor gene should be re-evaluated. Because some aberrant transcripts could be found at the first PCR reaction, we suggest that the aberrant transcripts might be the result of imperfect minor splicesome products.  (+info)

A possible involvement of aberrant expression of the FHIT gene in the carcinogenesis of squamous cell carcinoma of the uterine cervix. (8/4848)

To investigate involvement of an aberrant expression of the FHIT (fragile histidine triad) gene in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by the reverse transcriptase polymerase chain reaction (RT-PCR) and cDNA sequence method in 32 cervical invasive carcinomas (25 squamous cell carcinomas and seven adeno- or adenosquamous carcinomas) and 18 of its precursor lesions [four low-grade and 14 high-grade cervical intraepithelial neoplasias (CINs)]. We also examined a link between the occurrence of the aberrant expression and human papillomavirus (HPV). We detected the aberrant FHIT transcripts in 11 of 25 (44%) cervical invasive squamous cell carcinomas and in 5 of 14 (36%) high-grade CINs (CIN 2 or 3), whereas they were not found in seven non-squamous type and four low-grade CINs (CIN 1). The alteration patterns of the FHIT gene expression in high-grade CINs were virtually similar to those found in invasive carcinomas, such that the exons 5-7 were consistently deleted associated or unassociated with loss of the exon 4 and/or 8. The incidence of the aberrant expression was not related to the presence of HPV and its type. These data indicate that the aberrant expression of the FHIT gene is observed in precursor lesions of cervical carcinoma as well as invasive carcinomas, with its incidence not increasing with advance of clinical stage. Given the squamous cell type dominant expression, the aberrant expression may play a critical role in the generation of squamous cell carcinoma of the uterine cervix, but not the consequence of the progression of the cancer.  (+info)

TY - JOUR. T1 - Smokers at higher risk for undetected antibody for oncogenic human papillomavirus type 16 infection. AU - Wiley, Dorothy J.. AU - Wiesmeier, Edward. AU - Masongsong, Emmanuel. AU - Gylys, Karen H.. AU - Koutsky, Laura A.. AU - Ferris, Daron Gale. AU - Barr, Eliav. AU - Rao, Jian Yu. PY - 2006/5/1. Y1 - 2006/5/1. N2 - Objective: To determine the association between tobacco smoking and serologic evidence of human papillomavirus type 16 (HPV16)-specific antibodies among HPV16 DNA-positive women. Design, Setting, and Participants: Baseline health history, physical examination, and laboratory data for 205 HPV16 DNA-positive women with no prior cytologic evidence of squamous intraepithelial lesions who were enrolled subsequently in a randomized clinical trial. Main Outcome Measure: HPV16-L1 antibody (anti-HPV16 antibody) detected from serum using RIA or ELISA. Results: Eighty-seven percent (179 of 205) of women tested positive for HPV16 DNA using cervicovaginal swabs or lavage ...
We have sequenced 1730 bp of human papilloma virus type 18 (HPV 18) DNA containing the open reading frames (ORF) E6, E7, the N-terminal part of E1 and, additionally, 120 bp of the N-terminal part of L1. Based on these sequencing data, together with the human papilloma virus type 16 (HPV 16) DNA sequence published recently, we identified and cloned the ORF E6, E7, E1 and L1 of HPV 18 and the ORF E6, E7, E1, E4, E5, L2 and L1 of HPV 16 into prokaryotic expression vectors. The expression system used provides fusions to the N-terminal part of the MS2 polymerase gene controlled by the heat-inducible lambda PL promoter. Using the purified fusion proteins as immunogens we raised antisera against the proteins encoded by the ORF E6, E7 and E1 of HPV 18 as well as those encoded by the ORF E6, E7, E4 and L1 of HPV 16. By Western blot analysis we could show that the E7 gene product is the most abundant protein in cell lines containing HPV 16 or HPV 18 DNA. It is a cytoplasmic protein of 15 kd in the SiHa and the
Human papillomavirus type 11 L1 protein, Human papillomavirus type 16 L1 protein, Human papillomavirus type 18 L1 protein, Human papillomavirus type 31 L1 protein, Human papillomavirus type 33 L1 protein, Human papillomavirus type 45 L1 protein, Human papillomavirus type 52 L1 protein, Human papillomavirus type 6 L1 protein, Human papillomavirus type 58 L1 ...
E7 proteins are major oncoproteins of high-risk human papillomaviruses (HPVs), which play a key role in cervical carcinogenesis. These proteins have been shown to immortalize primary human cells. Due to the absence of antibodies with suitable sensitivity and specificity, little is known about expression of the E7 oncoproteins in naturally infected tissues. Recently, high-level expression of the E7 protein of HPV-16, the most prevalent oncogenic HPV type, was demonstrated in cervical carcinomas by immunohistochemistry; however, approximately 15 additional high-risk HPV types are known to be associated with cervical carcinoma. It is unknown whether the E7 oncoproteins of HPV-18 and -45, the second and third most prevalent HPV types, are expressed in cervical cancers. Using antibodies against HPV-18 and -45 E7 proteins, it is shown here for the first time that the HPV-18 and -45 E7 proteins can be detected in cervical carcinoma biopsies. Together with anti-HPV-16 E7 antibodies, this could create the
The polymerase chain reaction (PCR) has been used to amplify the long control region (LCR) of episomal human papillomavirus type 16 from cervical scrape DNA obtained from a woman with no evidence of cervical disease and a woman with cervical intraepithelial neoplasia grade 3 (CIN 3). An 883 base pair fragment containing the entire LCR was cloned into pUC13 and the DNA sequence determined for both isolates and compared with the prototype HPV type 16 LCR DNA sequence. Nucleotide variation was apparent in the LCRs derived from both women. In the case of the sample derived from the woman with no cervical disease, there were three nucleotide deletions, one insertion, four transversions, and three transitions (overall conservation: 98.7%). In contrast, the LCR derived from the woman with CIN 3 showed significantly more nucleotide variation with two nucleotide deletions, one insertion, nine transversions, and ten nucleotide transitions (overall conservation 97.6%). Using computer analyses coupled with
TY - JOUR. T1 - The impact of HIV infection and immunodeficiency on human papillomavirus type 6 or 11 infection and on genital warts. AU - Silverberg, Michael J.. AU - Ahdieh, Linda. AU - Munoz, Alvaro. AU - Anastos, Kathryn. AU - Burk, Robert D.. AU - Cu-Uvin, Susan. AU - Duerr, Ann. AU - Greenblatt, Ruth M.. AU - Klein, Robert S.. AU - Massad, Stewart. AU - Minkoff, Howard. AU - Muderspach, Laila. AU - Palefsky, Joel. AU - Piessens, Eva. AU - Schuman, Paula. AU - Watts, Heather. AU - Shah, Keerti V.. PY - 2002. Y1 - 2002. N2 - Background: HIV infection and associated immunodeficiency are known to alter the course of human papillomavirus (HPV) infections and of associated diseases. Goal: This study investigated the association between HIV and HPV and genital warts. Study Design: HPV testing and physical examinations were performed in two large prospective studies: the Womens Interagency HIV Study (WIHS) and the HIV Epidemiology Research Study (HERS). Statistical methods incorporating ...
High-risk human papillomavirus type 16 (HPV16) is a risk factor for cervical cancer. Previous studies suggest that polymorphisms in the E6 gene or the long control region(LCR)of HPV16 may alter the oncogenic potential of the virus. The aims of this study were to investigate the genetic variations of HPV16 E6 gene and LCR in isolates from Chinese population and correlation of the E6 and LCR polymorphisms with disease status of infected patients. HPV16 positive endocervical specimens were collected from 304 women living in Northeast of China. Sequences of E6 gene and LCR were analyzed by PCR-sequencing. Two lineages were found in the populations, including EUR lineage and As lineage. Based on the HPV16 prototype, the most frequent variation in the E6 gene was T178A/G (48.7%), followed by mutations of G94A (12.2%) and T350G (9.9%). The rank orders of incidence of E6 variations in amino acid were as follows: D25E (46.3%), L83V (9.9%) and H78Y (4.3%). Nucleotide variations in LCR were found in all the 304
The activity and epithelial tropism of the human papillomavirus type 18 P105 early promoter, which directs the synthesis of the E6 and E7 transforming genes, are controlled by cis elements included in the viral long control region. To identify potential cellular regulators of this promoter, we mutagenized one or both of the 5-TGACTAA-3 cis elements capable of interacting with the AP1 transcription factor, which is composed either of homodimers or heterodimers of the Jun products or of heterodimers of Jun and Fos. Mutation of both elements completely abolished P105 promoter activity in human keratinocytes. We show that either AP1 site can interact efficiently in vitro with any of the three different Jun products as heterodimers with c-Fos. However, in nuclear extracts prepared from human keratinocytes, JunB was the predominant Jun component bound to the DNA probe containing this cis element. These results implicate JunB as an important factor in human papillomavirus type 18 transcription in ...
Cervical carcinoma cells producing high levels of interleukin-6 (IL-6) were shown to be unresponsive to the cytokine IL-6 due to the loss of their IL-6 receptor. Addition of IL-6 receptor in a soluble form restores IL-6 signalling in SW756 carcinoma cells. This leads to a rapid and strong activation of the transcription factor signal transducer and activator of transcription 3 (STAT3). Nuclear factor IL-6 (NF-IL6, C/EBPβ) was induced only as a late event. While C/EBPβ significantly repressed the human papillomavirus type 18 long control region (HPV18-LCR), IL-6 signalling unexpectedly activated the HPV18-LCR in these cells. This IL-6 receptor-mediated induction could be completely reverted by transfection of a dominant-negative STAT3 but not STAT1 expression construct, indicating that STAT3 might play an important role in HPV18 oncogene promoter activation.
CLINICAL INVESTIGATION (Araflt rma) DIAGNOSING HUMAN PAPILLOMAVIRUS AND HUMAN PAPILLOMAVIRUS TYPE 16 BY REALTIME PCR IN PATIENT UNDERGONE TO COLPOSCOPY AND SIGNIFICANCE OF THE DIAGNOSIS Sibel OZDAS 1,
TY - JOUR. T1 - Expression of the human papillomavirus type 11 E5A protein from the [email protected]?E4,E5 transcript. AU - Brown, Darron R.. AU - McClowry, Tracy L.. AU - Sidner, Richard A.. AU - Fife, Kenneth H.. AU - Bryan, Jonine T.. PY - 1998/8/1. Y1 - 1998/8/1. N2 - The abundant human papillomavirus type II (HPV 11) [email protected]?E4,E5 transcript potentially encodes the [email protected]?E4,E5a and E5b proteins. It is not known if either of the E5 proteins are expressed from this transcript. For HPV 16, E5 is a single open reading frame (ORF), and the E5 protein is expressed from an unspliced E2,E5 transcript but not from tile spliced [email protected]?E4,E5 transcript. This study was undertaken to determine if the HPV 11 E5a protein is expressed from the [email protected]?E4,E5 transcript. To detect E5a expression in eukaryotic cells, the green fluorescent protein (GFP) gene was fused to the [email protected]? end of the E5a gene in the pEGFP-N1 vector. Several recombinant plasmid constructs were made to determine if E5a translation is influenced by upstream ...
TY - JOUR. T1 - Molecular cloning, analysis, and chromosomal localization of a mouse genomic sequence related to the human papillomavirus type 18 E5 region. AU - Kahn, Tomas. AU - Friesl, Holger. AU - Copeland, Neal G.. AU - Gilbert, Debra J.. AU - Jenkins, Nancy A.. AU - Gissmann, Lutz. AU - Kramer, Judith. AU - Hausen, Harald Zur. PY - 1992/1/1. Y1 - 1992/1/1. N2 - The E5 open reading frame (ORF) from bovine papillomavirus type 1 (BPV 1) as well as the E5 ORFs from human papillomaviruses (HPV) type 6 and type 16 have been reported to transform immortalized rodent cells. In an analysis of murine and human tumors for the presence of putative papillomavirus-related sequences, we cloned amplified cellular sequences from the mouse cell line Eb that cross-hybridized with the E5 ORF of HPV 18. A 2.1-kb fragment termed HC1 was sequenced. In normal murine cells, it was present as a single-copy genomic sequence located on chromosome 8. A region of 213 nucleotides corresponded to the E5 gene (HC1 E5), ...
TY - JOUR. T1 - Serum Immunoglobulin A Response to Human Papillomavirus Type 16 Virus-Like Particles in Human Immunodeficiency Virus (HFV)-Positive and High-Risk HIV-Negative Women. AU - Viscidi, Raphael P.. AU - Ahdieh-Grant, Linda. AU - Schneider, Michael F.. AU - Clayman, Barbara. AU - Massad, L. Stewart. AU - Anastos, Kathryn M.. AU - Burk, Robert D.. AU - Minkoff, Howard. AU - Palefsky, Joel. AU - Levine, Alexandra. AU - Strickler, Howard. PY - 2003/12/15. Y1 - 2003/12/15. N2 - Serum samples from 2008 human immunodeficiency virus (HIV)-positive and 551 HIV-negative women were tested for immunoglobulin A (IgA) to human papillomavirus (HPV) type 16 capsids. IgA seropositivity was lower than previously reported IgG seropositivity (7% vs. 51%), but, like IgG antibodies, HPV 16 IgA was associated with sexual behavior, cervicovaginal HPV 16 DNA, and cytological abnormalities. IgA seropositivity was higher in HIV-positive women than in HIV-negative women (7.7% vs. 4.9%; P = .02), but the ...
TY - JOUR. T1 - The interaction between steroid hormones, human papillomavirus type 16, E6 oncogene expression, and cervical cancer. AU - Moodley, M. AU - Sewart, S. AU - Herrington, C. S. AU - Chetty, R. AU - Pegoraro, R. AU - Moodley, J. PY - 2003. Y1 - 2003. N2 - Various risk factors have been implicated in the causation of cervical cancer including human papillomavirus (HPV), the early genes (E6 and E7 ) of which encode the main transforming proteins. Studies have suggested that steroid hormones may enhance the expression of these genes leading to loss of p53 gene-mediated cell apoptosis. A total of 120 cervical tissue samples were obtained from patients with proven cervical cancer. Patients who used depo-medroxyprogesterone acetate steroid contraception were recruited as part of the steroid arm. Only HPV DNA type 16 samples were used for the study. Controls included three cell lines (CaSki, SiHa, & C33A) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as an internal ...
Accuracy and cost-effectiveness of cervical cancer screening by high-risk human papillomavirus DNA testing of self-collected vaginal samples.
Human Papilloma virus type 16 E6 antibody for WB. Anti-Human Papilloma virus type 16 E6 pAb (GTX132686) is tested in Human papillomavirus samples. 100% Ab-Assurance.
TY - JOUR. T1 - Cooperation between Different Forms of the Human Papillomavirus Type 1 E4 Protein To Block Cell Cycle Progression and Cellular DNA Synthesis. AU - Knight, G. L.. AU - Grainger, J. R.. AU - Gallimore, P. H.. AU - Roberts, S.. PY - 2004/12/15. Y1 - 2004/12/15. N2 - Posttranslational modification-oligomerization, phosphorylation, and proteolytic cleavage-of the human papillomavirus (HPV) E4 protein occurs as the infected keratinocytes migrate up through the suprabasal wart layers. It has been postulated that these events modify E4 function during the virus life cycle. In HPV type 1 (HPV1)-induced warts, N-terminal sequences are progressively cleaved from the full-length E4 protein (E1∧E4) of 17 kDa to produce a series of polypeptides of 16, 11 and 10 kDa. Here, we have shown that in human keratinocytes, a truncated protein (E4-16K), equivalent to the 16-kDa species, mediated a G2 arrest in the cell cycle that was dependent on a threonine amino acid in a proline-rich domain of the ...
1. Walboomers JM, Jacobs MV, Manos MM. et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189(1):12-9 2. Burd EM. Human papillomavirus and cervical cancer. Clin Microbiol Rev. 2003;16(1):1-17 3. Boyer SN, Wazer DE, Band V. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res. 1996;56(20):4620-4 4. Thomas M, Pim D, Banks L. The role of the E6-p53 interaction in the molecular pathogenesis of HPV. Oncogene. 1999;18(53):7690-700 5. Thierry F. Transcriptional regulation of the papillomavirus oncogenes by cellular and viral transcription factors in cervical carcinoma. Virology. 2009;384(2):375-9 6. Badaracco G, Venuti A, Sedati A. et al. HPV16 and HPV18 in genital tumors: significantly different levels of viral integration and correlation to tumor invasiveness. J Med Virol. 2002;67(4):574-82 7. Romanczuk H, Howley PM. Disruption of either the E1 or the E2 regulatory ...
Human papillomaviruses (HPV) are small, double-stranded DNA viruses that infect epithelial cells and lead to the production of warts. A subset of HPVs infect the anogenital tract and can be placed into two categories, the low- and high-risk genotypes. While both low- and high-risk HPV genotypes lead to the production of warts, the high-risk genotypes are also associated with anogenital cancers including cervical cancer. HPV-16 is the genotype most commonly found in cervical cancer (31). The HPV life cycle is intimately tied to the differentiation of the host epithelium that it infects. The HPV life cycle begins in the basal layer of the epithelium, where the virus is thought to gain entry at a site of wounding. In this layer of the epithelium, the nonproductive stage of the HPV life cycle occurs, where the virus establishes itself as a low-copy-number episome by synthesizing its DNA on average once per cell cycle via a bidirectional theta mode (1a, 8, 12, 30). The productive stage of the HPV ...
Index Which other diagnostic measures besides the Pap test can be performed In most European countries testing for HPV is currently not performed directly as a screening method Instead it is frequently used as a triage of women who already were diagnosed with abnormalities in the Pap test Then it is also paid by health insurances Back to Index What are low and high risk HPV types The genital HPV types are classified into two groups low and high risk HPV Low risk HPV e g 6 11 42 43 44 are almost never detected in case of a cervical cancer High risk HPV types e g 16 18 31 33 35 39 45 51 52 56 58 are detected in 99 7 of all cervical cancer cases In 70 of the cases HPV16 and HPV18 are detected Only women with long term infection with high risk HPV and subsequent cervical lesions have a risk of developing precancerous lesions and cancer It is well established nowadays that HPV infection ist he main risk factor for the development of cervical cancer Back to Index How can I get to know if I am infected ...
Human papillomavirus (HPV) DNA detection in cervical specimens was correlated with cytologic and histologic diagnoses for 151 women who were referred to the Johns Hopkins Hospital colposcopy clinic for evaluation of an abnormal Pap smear. HPVs were identified as high-risk or low-risk by Hybrid C …
Human papillomaviruses (HPVs) are small double‐stranded DNA viruses that are associated with greater than 95% of cervical cancers and 20% of head and neck cancers
Following cleaning with detergent and water at the end of the working day (sampling 1), nine of the 20 surfaces tested were contaminated. It was decided to clean surfaces with a more stringent agent. After subsequent cleaning with Clearsol solution HPV DNA was present on one surface at the beginning of the day, and on four at the end of the day.. β Globin DNA was detected in all HPV DNA positive samples, indicating HPV was cell associated, and in a further five samples taken at the end of the day from HPV DNA negative surfaces.. Compared to our previous study a 50% reduction in surface contamination with HPV DNA was found after cleaning with detergent and the number of types detected was reduced. Only HPV types 6, 11, 16, and 58 were detected on the nine different surfaces. This is also a 73% reduction in the number of types detected in our previous study.1 HPV types 6, 11, and 16 were still the most common types found (all types in table 1).. Three of the samples positive for β globin DNA but ...
High Risk HPV Types - By safe natural ways, comfortably develop immunity to HPV infections and trouble, like abnormal Pap smears and cervical dysplasia, and as a benefit escape damaging surgical procedures.
The high-risk types of human papillomaviruses (HPV), in particular PV 16 and 18 are responsible for the development of almost all cases of cervical cancer, for a substantial fraction of other malignant anogenital tumors (penis, vulva and perianum) and for a proportion of head and neck cancer. The natural history of HPV infections and immunization experiments in animals with their respective papillomaviruses (e.g. the canine oral papillomavirus) clearly revealed the involvement of the immune system in controlling the viral infections and the diseases associated therewith. Antibodies appear to be the key molecules in preventing of an infection whereas mostly T cells and cytokines are involved in controlling virus persistence and progression towards malignancy. During the natural course of infection human papillomaviruses are not particularly immunogenic since their biology makes them barely visible by the immune system (infection is confined to the epithelium) but also since it has acquired ...
PURPOSE: Human papillomavirus (HPV) type 16 (HPV16) causes cancer at several anatomic sites. In the European Prospective Investigation Into Cancer and Nutrition study, HPV16 E6 seropositivity was present more than 10 years before oropharyngeal cancer diagnosis and was nearly absent in controls. The current study sought to evaluate the extent to which HPV16 E6 antibodies are present before diagnosis of anogenital cancers within the same cohort. METHODS: Four hundred incident anogenital cancers (273 cervical, 24 anal, 67 vulvar, 12 vaginal, and 24 penile cancers) with prediagnostic blood samples (collected on average 3 and 8 years before diagnosis for cervix and noncervix cancers, respectively) and 718 matched controls were included. Plasma was analyzed for antibodies against HPV16 E6 and multiple other HPV proteins and genotypes and evaluated in relation to risk using unconditional logistic regression. RESULTS: HPV16 E6 seropositivity was present in 29.2% of individuals (seven of 24 individuals) who
The 62 women had a median age of 56 years, and 39% had high-risk behavior known to be associated with HPV. Ten of 62 patients (16.1%) had high-risk HPV at baseline screening, 5 of whom had atypical cytology. All of the patients who were positive for high-risk HPV had an etiology of hepatitis C virus (HCV) as the underlying cause of liver disease, with the majority (90%) having no history of high-risk behavior for HPV. In contrast, all patients with high-risk behavior who were HCV negative were HPV negative. Fishers exact test demonstrated a statistically significant relationship between HPV and HCV; odds ratio = 24.4, 95% confidence interval, 1.4, 438.7, P-value = 0.0013. None of the other potential risk factors were associated with HPV in this cohort. ...
Human papillomavirus cause cancer, Sinonimele și antonimele HPV în dicționarul de sinonime Engleză Conținutul Involvement of Human Papillomavirus genome in oncogenesis of cervical cancer Involvement of Human Papillomavirus genome in oncogenesis of cervical cancer Aceste exemple pot conține termeni colocviali. Principalele semne că ficatul suferă şi cele mai importante gesturi care-l protejează Fosfataza alcalină enzimă ce se elimină prin bilă creşte în icterul mecanic obstrucţia fluxului biliar către tubul digestiv.
Cytidine deaminases of the APOBEC3 family all have specificity for single-stranded DNA, which may become exposed during replication or transcription of double-stranded DNA. Three human APOBEC3A (hA3A), hA3B, and hA3H genes are expressed in keratinocytes and skin, leading us to determine whether genetic editing of human papillomavirus (HPV) DNA occurred. In a study of HPV1a plantar warts and HPV16 precancerous cervical biopsies, hyperedited HPV1a and HPV16 genomes were found. Strictly analogous results were obtained from transfection experiments with HPV plasmid DNA and the three nuclear localized enzymes: hA3A, hA3C, and hA3H. Thus, stochastic or transient overexpression of APOBEC3 genes may expose the genome to a broad spectrum of mutations that could influence the development of tumors.
Human papillomaviruses have been implicated as a causative agent in the etiology of many human cancers, especially cervical carcinomas. Our laboratory had previously shown that the presence of the steroid hormones, dexamethasone and progesterone, markedly enhances the transformation of primary rodent cells by HPV type 16 DNA in cooperation with the EJ-ras oncogene. This enhancement could have been direct, through a previously known glucocorticoid response element (GRE) located at nt position 7640 in the transcriptional regulatory region of the HPV 16 genome. Two additional GRE-like sequences were also found at nt positions 7385 and 7474. Alternatively, indirect mechanisms could be conceived through hormone-mediated expression of other cellular transcription factors which in turn modulate HPV gene expression. To address the role of the GRE located at nt position 7640, site-directed mutational analysis was performed. In transformation assays in cultured rodent cells and in transient CAT assays ...
Bacterial vaginosis is associated with uterine cervical human papillomavirus papillomaviruses oncogenic a meta-analysis. În funcţie de capacitatea de oncogeneză, aceste genotipuri se subîmpart în HPV cu risc scăzut, asociate în principal cu verucile ano-genitale 6, 11, 40, 43, 44, 54, şi 70şi HPV cu risc înalt, asociate cu leziuni premaligne şi maligne 16, 18, 26, 31, 33, 35, 39, 45, papillomaviruses oncogenic, 52, 53, 56, 58, 59, 66, 68, papillomaviruses oncogenic şi 82 4. Conform datelor din Statele Unite ale Americii, cele mai frecvente motive pentru care oamenii refuză vaccinul HPV este lipsa de informaţii, frica de efectele adverse, necunoaşterea beneficiilor şi altele
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1.HPV is easily spread through direct skin to skin contact. As sexual intercourse is not necessary, any kind of sexual activity involving genital contact will lead to genital HPV infection.. 2.In general, HPV infection does not give any signs or symptoms, so most people dont even know of having it. This is one of the main reasons why most people get infected. On the plus side, the human body is able to fight this infection on its own, providing the immune system is at its best.. 3.The majority of the HPV types are not life-threatening, but they do put you at a higher risk of cancer because they change the cell structure of the cervix turning it into cervical cancer. If women leave the low-risk types of the virus untreated, benign (abnormal but non-cancerous) changes in the cervix can develop. Over time, this can set the ground for cervical cancer.. 4.A number of studies confirm that women infected with the high-risk HPV are more susceptible to developing cervical cancer in the next 10 - 20 ...
One thing I was surprised about is that when I go to the comment page and click on original post it doesnt show the picture of the microbe but rather shows the text [Photo]. I have to admit that I did not realize these were actual photographs. Great job catching them in such good poses! ...
Dear Mr. Gardner:. Thank you for taking time to respond to our September 2, 2011 letter addressed to Commissioner Hamburg, informing the FDA of our discovery of recombinant HPV DNA in Merck & Co.s HPV 4 vaccine, Gardasil currently marketed worldwide.. Your response dated September 22, 2011 seems to indicate that the FDA is unaware of, or indifferent to the harms HPV vaccines have brought to medical consumers; primarily adolescent girls, as documented in the VAERS reports. Do you know how many parents have lost their perfectly healthy young daughters and how many parents still have to deal with the hardship of caring for their physically disabled or mentally impaired daughters as a result of Gardasil vaccinations?. There are at least seven reports published in the peer-reviewed medical journals containing documented links between HPV vaccination and a class of newly recognized, probably immune-mediated inflammatory neurodegenerative disorders, also described under the name of acute disseminated ...
Dear Mr. Gardner:. Thank you for taking time to respond to our September 2, 2011 letter addressed to Commissioner Hamburg, informing the FDA of our discovery of recombinant HPV DNA in Merck & Co.s HPV 4 vaccine, Gardasil currently marketed worldwide.. Your response dated September 22, 2011 seems to indicate that the FDA is unaware of, or indifferent to the harms HPV vaccines have brought to medical consumers; primarily adolescent girls, as documented in the VAERS reports. Do you know how many parents have lost their perfectly healthy young daughters and how many parents still have to deal with the hardship of caring for their physically disabled or mentally impaired daughters as a result of Gardasil vaccinations?. There are at least seven reports published in the peer-reviewed medical journals containing documented links between HPV vaccination and a class of newly recognized, probably immune-mediated inflammatory neurodegenerative disorders, also described under the name of acute disseminated ...
Human Papilloma virus (HPV) are viruses that cause a common infection of the skin and genitals in men and women. Several types of HPV infection are transmitted by sexual activity and, in women, can infect the cervix (part of the uterus or womb). This infection often goes away by itself, but if it does not go away (this is called persistent infection), it can lead in women over a long period of time to cancer of the cervix. If a woman is not infected by HPV, it is very unlikely that she will get cervical cancer. This study will evaluate the efficacy of GSK Biologicals HPV 16/18 VLP/AS04 vaccine to prevent infection associated cervical pre-cancer and vaccine with HPV 16 or 18 and the vaccine safety, over 48 months, in young adolescents and women of 15/25 years of age at study start. Approximately 18.000 study subjects will either receive the HPV vaccine or a control vaccine (hepatitis A vaccine) administered intramuscularly according to a 0-1-6 month schedule.. The Protocol Posting has been ...
Human Papilloma virus (HPV) are viruses that cause a common infection of the skin and genitals in men and women. Several types of HPV infection are transmitted by sexual activity and, in women, can infect the cervix (part of the uterus or womb). This infection often goes away by itself, but if it does not go away (this is called persistent infection), it can lead in women over a long period of time to cancer of the cervix. If a woman is not infected by HPV, it is very unlikely that she will get cervical cancer. This study will evaluate the efficacy of GSK Biologicals HPV 16/18 VLP/AS04 vaccine to prevent infection associated cervical pre-cancer and vaccine with HPV 16 or 18 and the vaccine safety, over 48 months, in young adolescents and women of 15/25 years of age at study start. Approximately 18.000 study subjects will either receive the HPV vaccine or a control vaccine (hepatitis A vaccine) administered intramuscularly according to a 0-1-6 month schedule.. The Protocol Posting has been ...
Human papillomavirus (HPV) is causative for a fresh and increasing type of mind and ML314 throat squamous cell carcinomas (HNSCCs). and level of resistance to Path weighed against HPV-negative mind and throat cancer tumor cell lines. All TRAIL-resistant HPV-positive cell lines tested were sensitised to TRAIL-induced cell death by treatment with bortezomib a clinically authorized proteasome inhibitor. Bortezomib-mediated sensitisation to TRAIL was associated with enhanced activation of caspase-8 -9 and -3 elevated membrane expression levels of TRAIL-R2 cytochrome launch and G2/M arrest. Knockdown of caspase-8 significantly blocked cell death induced from the combination therapy whereas the BH3-only protein Bid was not required for induction of apoptosis. XIAP depletion improved the level of sensitivity of both HPV-positive and -bad cells to TRAIL only or in combination with bortezomib. In contrast repair of p53 following E6 knockdown in HPV-positive cells experienced no effect on their level of ...
Acest papilomavirus uman human papillomavirus sau, pe scurt, HPV cauzeaza aproape toate cazurile de cancer de col uterin. Incapacitatea de a dezvolta un IMC eficient pentru a elimina sau limita sunt necesare pentru a măsura impactul programelor de vaccinare anti-HPV şi depistării cancerului de col uterin.
Veruci comune Fig 2. Parteneri: It is Opiuni terapeutice n infecia HPV difficult to assess whether in this genital human papillomavirus hpv infection is best defined as a the individual remains infectious or not. If genitale.
Human papillomavirus (HPV) 16 and HPV 18 E2 amino acid variants and host HLA DR/DQ haplotypes have been identified by direct nucleic acid sequencing from cervical scrapes. HPV16 E2 variants co-segregate with a nucleotide variant at nt350 (in E6), which previously has been associated with persistent …
We confirmed that HPV viral load was higher among HPV-16- and/or HPV-18-positive women with any prevalent cervical abnormality compared with cytologically normal women, independent of the assay used for viral load determination. However, the association between viral load and lesion severity varied by assay and genotype.. HPV-16 viral load, as measured by real-time PCR, was associated with increasing severity of cervical neoplasia, even after adjustment for specimen cellularity. The main effect of adjustment for cellularity was a relative decrease in the HPV-16 viral load among the 30 women with equivocal cytological diagnoses who had somewhat higher cell equivalents/unit volume. In contrast to earlier reports, the mean cell concentration/sample did not vary significantly between lesion grades, although the generalizability of our observations is limited to HPV-16 and/or HPV-18-infected women (7) . The explanation for this discrepancy between our results and those reported previously is unclear. ...
Results The seroprevalence for any HPV type and any of the types HPV-6/11/16/18 was 64.8% and 34.4%, respectively. 30.3% of adults were seropositive for any mucosal high-risk (HR) HPV, and HPV-58 (10.6%), HPV-16 (9.7%) and HPV-18 (9.3%) were the three most common types. 24.8% of seropositive individuals were positive for multiple mucosal HR-HPV serotypes. Seroprevalence for most HPV types was similar among men and women. While mucosal low-risk HPV seropositivity was found to significantly decrease with age, the prevalence of antibodies to mucosal HR antigens showed a general trend of increase with age. The lifetime number of sex partners was independently associated with mucosal HR-HPV seropositivity. Positive correlation of spousal seropositivity was observed for mucosal HPV but not for cutaneous HPV.. ...
Human Papilloma virus (HPV) are viruses that cause a common infection of the skin and genitals in men and women. Several types of HPV infection are tra
Human papillomavirus antigen was found in 39 (16%) of 253 colposcopic biopsies from a group of women at high risk for cervical cancer who had been examined in the early 1970s. Immunohistochemical evidence of papillomavirus infection was found in 20 (30%) of 67 cervical intraepithelial neoplasia lesions infected with wart virus from these patients. When these results were compared with results of a similar study carried out in the early 1980s there was no significant difference in the prevalence of human papillomavirus antigen in cervical intraepithelial neoplasia lesions infected with wart virus from women who had been examined over a decade apart.. ...
RESULTS:. The 42 selected articles enrolled 4066 patients. It was observed that oral or oropharyngeal human papillomavirus infections were identified in 738 patients (18.2%; IC 95 17.6-18.8), varying between 0.0% and 91.9%. The prevalences of oral or oropharyngeal human papillomavirus infections were respectively 6.2%, 44.6%, 44.4%, 27.4%, 38.5% and 11.9% for healthy people, those with benign oral lesions, pre-malignant lesions, oral or oropharyngeal squamous cell carcinoma, risk groups (patients with genital human papillomavirus lesions or infected partners) and immunocompromised patients. The risk of human papillomavirus infection was estimated for each subgroup and it was evident that, when compared to the healthy population, the risk of human papillomavirus infection was approximately 1.5-9.0 times higher, especially in patients with an immunodeficiency, oral lesions and squamous cell carcinoma. The rates of the most well-known oncogenic types (human papillomavirus 16 and/or 18) also show ...
Distribution of Human Papilloma Virus Infections of Uterine Cervix among Women of Reproductive Age - a Cross Sectional Hospital-Based Study from North East India Human papilloma virus;cervical cancer;squamous epithelial lesion;PCR;NILM;India; Infection of the uterine cervix by human papilloma viruses (HPV) may be associated with cervical pre-cancer and invasive cervical carcinoma if left untreated. With advance in molecular techniques, it has become easier to detect the resence of HPV DNA long before the appearance of any lesion. This study concerned cervical scrape samples of 310 married non-pregnant women attending a gynecology outpatient department for both Pap and PCR testing to detect HPV DNA. Nested PCR using primers for L1 consensus gene with My9/My11 and GP6+/GP5+followed by multiplex PCR were carried out to detect HPV 16 and HPV18. Result: HPV prevalence was 11.9% out of which 3.67% cases of negative for intra-epithelial lesion or malignancy (NILM) and in 71.1% (27/38) of atypical cervical
TY - JOUR. T1 - Open reading frame E3-10.9K of subspecies B1 human adenoviruses encodes a family of late orthologous proteins that vary in their predicted structural features and subcellular localization. AU - Frietze, Kathryn M.. AU - Campos, Samuel K.. AU - Kajon, Adriana E.. N1 - Copyright: Copyright 2015 Elsevier B.V., All rights reserved.. PY - 2010/11. Y1 - 2010/11. N2 - Subspecies B1 human adenoviruses (HAdV-B1s) are important causative agents of acute respiratory disease, but the molecular bases of their distinct pathobiology are still poorly understood. Marked differences in genetic content between HAdV-B1s and the well-characterized HAdV-Cs that may contribute to distinct pathogenic properties map to the E3 region. Between the highly conserved E3-19K and E3-10.4K/RIDα open reading frames (ORFs), and in the same location as the HAdV-C ADP/E3-11.6K ORF, HAdV-B1s carry ORFs E3-20.1K and E3-20.5K and a polymorphic third ORF, designated E3-10.9K, that varies in the size of its predicted ...
TY - JOUR. T1 - Isolation and cloning of the raccoon (Procyon lotor) papillomavirus type 1 by using degenerate papillomavirus-specific primers. AU - Rector, Annabel. AU - Van Doorslaer, Koenraad. AU - Bertelsen, Mads. AU - Barker, Ian K.. AU - Olberg, Rolf Arne. AU - Lemey, Philippe. AU - Sundberg, John P.. AU - Van Ranst, Marc. PY - 2005/7/1. Y1 - 2005/7/1. N2 - Partial sequences of a novel papillomavirus were amplified from a cutaneous lesion biopsy of a raccoon (Procyon lotor), by using PCR with degenerate papillomavirus-specific primers. The Procyon lotor papillomavirus type 1 (PlPV-1) DNA was amplified with long template PCR in two overlapping fragments, together encompassing the entire genome, and the complete PlPV-1 genomic sequence was determined. The PlPV-1 genome consists of 8170 bp, and contains the typical papillomaviral open reading frames, encoding five early proteins and two late capsid proteins. Besides the classical non-coding region (NCR1) between the end of L1 and the start of ...
TY - JOUR. T1 - A population-based cross-sectional study of age-specific risk factors for high risk human papillomavirus prevalence in rural Nigeria. AU - Clarke, Megan A.. AU - Gage, Julia C.. AU - Ajenifuja, Kayode O.. AU - Wentzensen, Nicolas A.. AU - Adepiti, Akinfolarin C.. AU - Wacholder, Sholom. AU - Burk, Robert D.. AU - Schiffman, Mark. PY - 2011/8/2. Y1 - 2011/8/2. N2 - Background: Cervical cancer, caused by persistent infection with carcinogenic human papillomavirus (HR-HPV), is particularly prevalent in Sub-Saharan Africa and is associated with a high mortality rate. Some studies in West Africa, including our own, have found unusually high HR-HPV across all ages with a slight peak in older women. This increased prevalence at older ages may complicate screen-and-treat programs, which are implemented in regions where HPV prevalence declines with age and typically target women between 30-49 years. A better understanding of the determinants of high HR-HPV prevalence at older ages is ...
Human papillomavirus infection is an infection by human papillomavirus (HPV). Most HPV infections cause no symptoms and resolve spontaneously. In some people, an HPV infection persists and results in warts or precancerous lesions. The precancerous lesions increase the risk of cancer of the cervix, vulva, vagina, penis, anus, mouth, or throat. Nearly all cervical cancer is due to HPV with two types, HPV16 and HPV18, accounting for 70% of cases. Between 60% and 90% of the other cancers are also linked to HPV. HPV6 and HPV11 are common causes of genital warts and laryngeal papillomatosis. An HPV infection is caused by human papillomavirus, a DNA virus from the papillomavirus family, of which over 170 types are known. More than 40 types are transmitted through sexual contact and infect the anus and genitals. Risk factors for persistent HPV infections include early age of first sexual intercourse, multiple partners, smoking, and poor immune function. HPV is typically spread by sustained direct ...
Human Papillomavirus Infection Definition: Human papillomavirus infection (HPV infection) is an infection by human papillomavirus (HPV) that is passed
Discussion. Genital HPV infection is the most common sexually transmitted disease. Taking into consideration of all the cervical cancer cases, 99,8% of the patients were infected by HPV. HPV infection may cause either genital wart, precancerous cervical lesions or cervical cancer. While more than 100 HPV subtypes exist, 30 subtypes may lead to infection in human. According to the oncogenicity potential, HPV types are classified as high risk (HR; type 16, 18, 31, 45, 51, 52, 59, 68) and low risk (LR; type 6 and 11) (1-4).. HPV infection prevalence exhibits regional variations. The incidence of HPV among 14-59 years of age Americans is 26,8% and the most common HPV subtype is type 6 (1,3%) (14), while this incidence is 17% in Spaniens and the most common HPV subtype is type 16 and 18 (15). On the other hand, among Indian women, type 16 is the most common HPV subtype and the incidence is 7,6% (16), in Denmark the percentage of the HPV infected women is 26,4 % type 16 is the most common one (6,0%) ...
TY - JOUR. T1 - Type-Specific Human Papillomavirus Prevalence, Incident Cases, Persistence, and Associated Pregnancy Outcomes among HIV-Infected Women in Kenya. AU - Vyankandondera, Joseph. AU - Wambua, Sammy. AU - Irungu, Eunice. AU - Mandaliya, Kishor. AU - Temmerman, Marleen. AU - Ryan, Claire. AU - Mohamed, Yasmin. AU - Vanden Broeck, Davy. AU - Verhelst, Rita. AU - Chersich, Matthew F.. AU - Luchters, Stanley. PY - 2019/8/1. Y1 - 2019/8/1. N2 - Background Persistent infection with high-risk types of human papillomavirus (HPV) is the preeminent factor driving the development of cervical cancer. There are large gaps in knowledge about both the role of pregnancy in the natural history of HPV infection and the impact of HPV on pregnancy outcomes. Methods This single-site prospective cohort substudy, nested within an international multisite randomized controlled trial, assessed prevalence, incident cases, and persistence of type-specific HPV infection, and the association between persistence of ...
Burden of Human Papilloma Virus Infection and Related Comorbidities in Men: Implications for Research, Disease Prevention and Health Promotion among Hispanic Men
Formalin-fixed, paraffin-embedded tissues from 108 cases of invasive carcinoma of the uterine cervix, consisting of 40 cases of adenocarcinoma, 44 cases of adenosquamous carcinoma, and, as a control, 24 cases of squamous cell carcinoma were examined for the presence of human papillomavirus (HPV) DNA by in situ hybridization of high sensitivity using tritium-labeled HPV-2, HPV-6, HPV-16, and HPV-18 DNA probes. This method detects five genome copies of homologous HPV DNA per cell. HPV DNA was detected with mixed HPV DNA probes in 17 cases (42.5%) of adenocarcinoma, 16 cases (36.4%) of adenosquamous carcinoma, and in 13 cases (54.2%) of squamous cell carcinoma. The types of HPV DNA in the HPV-positive tissues were also analyzed with each individual probe under high stringency conditions. HPV-18 DNA was detected in all but one case of the HPV DNA-positive adenocarcinoma and one-half of the HPV DNA-positive adenosquamous carcinoma. HPV-16 DNA was detected in one case of the HPV DNA-positive ...
Current cervical cancer screening guidelines recommend a Pap test every 3 years for women age 21-65 years, or for women 30-65 years who want to lengthen the screening interval, a combination of Pap test and high-risk human papilloma virus testing (co-testing) every 5 years. Little population-based data are available on human papilloma virus test utilization and human papilloma virus infection rates. The objective of this study was to examine the patient-level, cervical cancer screening, and area-level factors associated with human papilloma virus testing and infection among a diverse sample of uninsured and underinsured women enrolled in the New Jersey Cancer Early Education and Detection (NJCEED) Program. We used data for a sample of 50,510 uninsured/underinsured women, age ≥ 29 years, who screened for cervical cancer through NJCEED between January 1, 2009 and December 31, 2015. Multivariable logistic regression models were used to estimate associations between ever having a human papilloma virus
TY - JOUR. T1 - Hybrid capture 2 is as effective as PCR testing for high-risk human papillomavirus in head and neck cancers. AU - Hooper, Jody E.. AU - Hebert, Jessica F.. AU - Schilling, Amy. AU - Gross, Neil D.. AU - Schindler, Joshua. AU - Lagowski, James P.. AU - Kulesz-Martin, Molly. AU - Corless, Christopher. AU - Morgan, Terry. PY - 2015/4/22. Y1 - 2015/4/22. N2 - High-risk human papillomavirus (HPV) infection is a common cause of oropharyngeal squamous cell carcinoma, especially in young male nonsmokers. Accurately diagnosing HPV-associated oral cancers is important, because they have a better prognosis and may be treated differently than smoking-related oral carcinomas. Various methods have been validated to test for high-risk HPV in cervical tissue samples, and they are in routine clinical use to detect dysplasia before it progresses to invasive disease. Similarly, future screening for HPV-mediated oropharyngeal dysplasia may identify patients before it progresses. Our objective was to ...
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TY - JOUR. T1 - Distribution of Human Papillomavirus Types 16 and 18 Variants in Squamous Cell Carcinomas and Adenocarcinomas of the Cervix. AU - Burk, Robert D.. AU - Terai, Masanori. AU - Gravitt, Patti E.. AU - Brinton, Louise A.. AU - Kurman, Robert J.. AU - Barnes, Willard A.. AU - Greenberg, Mitchell D.. AU - Hadjimichael, Olympia C.. AU - Fu, Leiping. AU - McGowan, Larry. AU - Mortel, Rodrigue. AU - Schwartz, Peter E.. AU - Hildesheim, Allan. PY - 2003/11/1. Y1 - 2003/11/1. N2 - The distributions of human papillomavirus (HPV) types detected in cervical adenocarcinomas and squamous cell tumors differ. However, whether the distributions of intratypic HPV variants seen in these two histological forms of cervical disease differ is unknown. Our objective was to compare the distribution of HPV intratypic variants observed in squamous cell carcinomas (SCC) and cervical tumors of glandular origin (e.g., adenocarcinomas; AC) for two HPV types commonly observed in cervical tumors, HPV16 and HPV18. ...
Figure 1. Prevalence of the 15 most common HPV genotypes in 5,910 HPV-positive LSILs by region. *, Denominators of HPV-positive LSIL vary by HPV type, from 2,516 to 5,910 for all regions, from 268 to 2,746 for Europe, from 1,640 to 1,943 for North America, from 466 to 874 for South/Central America, from 62 to 178 for Africa, and from 160 to 169 for Asia. †, In Asia, upper 95% CI for HPV16 is 39.6%, and HPV53 is not shown because the denominator was 33 cases only. ...
TY - JOUR. T1 - Human papillomavirus type 16 E6-enhanced susceptibility of L929 cells to tumor necrosis factor α correlates with increased accumulation of reactive oxygen species. AU - Liu, Yun. AU - Tergaonkar, Vinay. AU - Krishna, Sudhir. AU - Androphy, Elliot J.. PY - 1999/8/27. Y1 - 1999/8/27. N2 - Human papillomavirus type 16 (HPV-16) E6 has been shown to prevent or enhance apoptosis depending on the stimulus and cell type. Here we present evidence that HPV-16 E6 sensitized murine fibrosarcoma L929 cells to tumor necrosis factor α (TNF)-induced cytolysis. The E6-enhanced cytolysis correlated with a precedent increase in reactive oxygen species (ROS) level and antioxidant treatment could completely block the E6-dependent sensitization. These findings represent the first demonstration of a link between a viral oncogene-sensitized cytolysis and ROS. Previous studies have shown conflicting results regarding whether TNF-induced cytolysis of L929 cells is through necrosis or apoptosis. Here we ...
Virus del papiloma humano tambien se busco papiloma humano virus concepto, papiloma humano en hombres sintomas human papillomavirus genome sequence tratamiento eozinofile crescute paraziti. Wart treatment recommendations, Terapii clasice și moderne ale verucilor cutanate și anogenitale Hpv treatment ncbi, Hpv cervical human papillomavirus ncbi ncbi Cancer cervical ncbi Cervical Cancer Staging duree incubation papillomavirus WhatsApp Utilizat frecvent în gastronomia asiatică ca şi condiment, turmericul Curcuma longa are numeroase beneficii foarte importante pentru sănătate, acțiunile antiinflamatoare, antioxidante şi antibacteriene fiind menționate chiar şi hpv and cancer ncbi hpv treatment ncbi medicale sanscrite. Quote Infectiile perinatale si persistenta tipurilor de HPV 16 si 18 la nou nascuti Studiu a fost realizat pentru a investiga daca infectarea cu HPV 16 si 18 a nou nascutilor contaminati la nastere persista pana la varsta de 6 luni.
Title:A Comprehensive Review on Cross-talk of Human Papilloma Virus Oncoproteins and Developmental/Self-Renewal Pathways During the Pathogenesis of Uterine Cervical Cancer. VOLUME: 21 ISSUE: 5. Author(s):Afza Ahmad and Irfan Ahmad Ansari*. Affiliation:Department of Biosciences, Integral University, Lucknow, 226026, Department of Biosciences, Integral University, Lucknow, 226026. Keywords:Cervical cancer, Human Papilloma Virus (HPV), Oncoproteins, Hedgehog, Wnt, Notch. Abstract:Cervical cancer, cancer arising from the uterine cervix, has been regarded as the fourth most frequent gynecological malignancy among females worldwide. Epidemiological reports have shown that uterine cervical cancer is a global health issue among women of especially developing countries and consequently creates an economic and medical burden in the society. The main causative agent of cervical carcinoma is high-risk human papilloma virus (HPV 16 and HPV 18). Molecular studies have revealed the expression of two viral ...
Persistent infection with high-risk human papilloma viruses: cohort study, Mérida, Venezuela Luis Téllez1, Elvia Michelli1, 2, José Andrés Mendoza1
Telomere maintenance is crucial in carcinogenesis and tumor progression. The results of a previous study from the authors indicated that infection with high-risk human papillomavirus (HR-HPV) types 16, 18, and 58 was a risk factor for esophageal squamous cell carcinoma (ESCC) in the Shantou region of China. In the current study, the authors explored the association between HR-HPV infection, telomere length (TL), and DNA methylation and their significance in the prognosis of patients with ESCC....
Natural history studies conducted over the past 20 years have demonstrated that human papillomavirus (HPV) infection is a necessary prerequisite for the development of cervical cancer (9). These studies have also demonstrated that among the 40 genital HPV types, only a subset of approximately 15 HPV types are oncogenic. Among these types, HPV type 16 (HPV16) is responsible for more than 50% of cervical cancers and an even higher proportion of HPV-related vulvar and vaginal cancers (1). Of all HPV types with a tropism for genital tissues, HPV16 is the most likely to persist and result in abnormal Pap test results and cervical dysplastic lesions (5).. While combining several antigens into one vaccine is an efficient means to broaden the vaccines coverage, such combination may result in immune interference, defined as the reduction in the immunogenicity of a vaccine antigen when it is administered as a component of a vaccine that includes multiple vaccine antigens. There are no physicochemical ...
TY - JOUR. T1 - Human papillomavirus DNA is present in a subset of unselected breast cancers. AU - Liu, Yong. AU - Klimberg, Vicki. AU - Andrews, Nancy R.. AU - Hicks, Carla R.. AU - Peng, Hui. AU - Chiriva-Internati, Maurizio. AU - Henry-Tillman, Ronda. AU - Hermonat, Paul L.. PY - 2001. Y1 - 2001. N2 - Objective: The major molecular events in the genesis of most breast cancers are unknown. However, human papillomaviruses (HPV) have been reported to be found in a significant portion of breast cancers of women with concomitant cervical intraepithelial neoplasia III. To investigate a potential HPV-breast cancer link, we carried out a small survey to identify HPV in unselected, general breast cancer tissues. Study Design/Methods: Deoxyribonucleic acid (DNA) was isolated from 17 breast cancer tissues (and one cervical swab) taken from our local, randomly selected patient population. Two different previously characterized broad-spectrum primer sets (targeting the E6/E7 or L1 regions) were used to ...
Previous studies have shown that epithelial cells immortalized by human papillomaviruses (HPVs) at late passages were more resistant to the effects of retinoic acid than late passage normal keratinocytes. Some of these late passage HPV-immortalized cells, however, lose the ability to form a cornified envelope with continued culturing. For this reason, early passage normal keratinocytes and early passage HPV-immortalized cells were studied to see if they also showed this resistance to retinoic acid. Normal epithelial cells and cells immortalized by HPVs were grown in organotypic raft cultures and treated with varying amounts of retinoic acid, which normally blocks terminal differentiation in keratinocytes. The cultures were grown for two weeks, fixed, sectioned, and stained with either hematoxylin and eosin (H&E) or an antibody against the keratin K1. The HPV-immortalized cell lines were found to be more resistant to the action of retinoic acid than the normal cells. The same cell lines were also ...
TY - JOUR. T1 - Differentiation-dependent changes in levels of C/EBPβ repressors and activators regulate human papillomavirus type 31 late gene expression. AU - Gunasekharan, Vignesh. AU - Haché, Guylaine. AU - Laimins, Laimonis. N1 - Copyright: Copyright 2013 Elsevier B.V., All rights reserved.. PY - 2012/5. Y1 - 2012/5. N2 - The liver-enriched transcriptional activator protein (LAP) isoform of CCAAT/enhancer binding proteinβ (C/EBPβ) is shown to be a major activator of differentiation-dependent human papillomavirus (HPV) late gene expression, while the liver-enriched inhibitory protein (LIP) isoform negatively regulates late expression. In undifferentiated cells, LIPs act as dominant-negative repressors of late expression, and upon differentiation, LIP levels are significantly reduced, allowing LAP-mediated activation of the late promoter. Importantly, knockdown of C/EBPβ isoforms blocks activation of late gene expression from complete viral genomes upon differentiation.. AB - The ...
Kamu bisa kunjungi Deteksi dini melalui Tes Pap Smear sebaiknya dilakukan seawal mungkin bagi para perempuan yang sudah pernah berhubungan seksual, dan dilakukan secara rutin sebanyak 1 kali setiap tahunnya untuk wanita yang masih aktif berhubungan seksual. Kondiloma akuminata atau yang lebih dikenal dengan kutil kelamin adalah salah satu gejala yang paling umum muncul akibat infeksi menular seksual. Penyakit papilloma virus Know More About Human Papilloma Virus HPV Infection treatment of helminth Vestibular papillomatosis went away endometrial cancer classification, hpv virus that causes cervical cancer detoxifiere post.
We report the prevalence of human papillomavirus type 16 (HPV-16) variants in women with cervical lesions from the Federal District, Central Brazil. We analyzed 34 HPV-16 samples, identifying the sequence variations of E6 and L1 genes and correlating variant frequency with disease status. The most prevalent HPV-16 variant was the European (50%), followed by Asian-American (41.2%), African-1 (5.9%), and African-2 (2.9%). European and non-European variants appeared in equal frequencies among the cytological types of lesions - atypical squamous or glandular cells of undetermined significance, cytological alterations suggesting HPV infection, cervical intraepithelial neoplasias, squamous cell carcinoma, and adenocarcinoma ...
Preanalytical conditions determine the reliability and validity of bioassays. Therefore, the analytic performances of biological tests need to be determined when preanalytical steps differ from those recommended by the manufacturer. The objective of the study was to assess the analytic performance of the hc2 test for the detection of high-risk HPV DNA from cells stored in the new Novaprep® HQ+ medium. Repeatability, reproducibility, method comparison and stability (-20 °C, +4 °C, +20 °C and +40 °C up to six months) were evaluated from HPV16 and HPV18 positive cell lines diluted in the Novaprep® HQ+ medium and the reference Specimen Transport Medium (STM). A series of cervical samples with atypical squamous cells of undetermined significance (ASC-US) cytology and stored in the Novaprep® HQ+ medium was also tested. Coefficients of variation for repeatability and reproducibility were less than 8 %. Method comparison showed perfect agreement in hc2 results when the HPV-positive cells were diluted in
Conținut posibil inadecvat Elimină filtrul Exemplele au rolul de a te ajuta să traduci cuvinte sau expresii corect si adaptat la context. Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta-analysis. Gynecol Oncol.
According to the National Cancer Institute, The most common test[which?] detects DNA from several high-risk HPV types, but it cannot identify the type(s) that are present. Another test[which?] is specific for DNA from HPV types 16 and 18, the two types that cause most HPV-associated cancers. A third test[which?] can detect DNA from several high-risk HPV types and can indicate whether HPV-16 or HPV-18 is present. A fourth test[which?] detects RNA from the most common high-risk HPV types. These tests can detect HPV infections before cell abnormalities are evident.. Theoretically, the HPV DNA and RNA tests could be used to identify HPV infections in cells taken from any part of the body. However, the tests are approved by the FDA for only two indications: for follow-up testing of women who seem to have abnormal Pap test results and for cervical cancer screening in combination with a Pap test among women over age 30. [107]. In April 2011, the Food and Drug Administration approved the cobas HPV ...
Conclusions Human immunodeficiency virus-positive men have a high burden of genital HPV infection and AGW. The ART and HPV vaccine could reduce this burden....
Human Papillomavirus (HPV). Genital human papillomavirus (also called HPV) is the most common sexually transmitted infection (STI). There are more than 40 HPV types that can infect the genital areas of males and females. These HPV types can also infect the mouth and throat. Most people who become infected with HPV do not even know they have it. HPV is not the same as herpes or HIV (the virus that causes AIDS). These are all viruses that can be passed on during sex, but they cause different symptoms and health problems.. How do people get HPV?. HPV is passed on through genital contact, most often during vaginal and anal sex. HPV may also be passed on during oral sex and genital-to-genital contact. HPV can be passed on between straight and same-sex partners-even when the infected partner has no signs or symptoms. A person can have HPV even if years have passed since he or she had sexual contact with an infected person. Most infected persons do not realize they are infected or that they are passing ...
Signs of Human Papillomavirus including medical signs and symptoms of Human Papillomavirus, symptoms, misdiagnosis, tests, common medical issues, duration, and the correct diagnosis for Human Papillomavirus signs or Human Papillomavirus symptoms.
Human papillomavirus, or HPV, is a common virus that affects both females and males. There are more than 100 types of the virus. In fact, certain types of HPV cause common warts on the hands and feet. Most types of HPV are harmless, do not cause any symptoms, and go away on their own. About 40 types of HPV are known as genital HPV as they affect the genital area. More than 50% of people (males and females) will be infected with at least one type of genital HPV at some time. Genital HPV types may be high-risk types (such as HPV Types 16 and 18) that can cause cervical pre-cancer and cancer, or low-risk types (such as HPV Types 6 and 11) that can cause genital warts and usually benign (abnormal but non-cancerous) changes in the cervix. Both the high-risk and low-risk types of HPV can cause abnormal Pap smears. Anyone who has any kind of sexual activity involving genital contact could get genital HPV. That means its possible to get the virus without having intercourse. And, because many ...
TY - JOUR. T1 - Comparison of human papilloma virus testing and spectroscopy combined with cervical cytology for the detection of high-grade cervical neoplasia. AU - Werner, Claudia L.. AU - Griffith, William F.. AU - Ashfaq, Raheela. AU - Gossett, Diana. AU - Wilkinson, Edward. AU - Raab, Stephen. AU - Bambot, Shabbir. AU - Mongin, David. AU - Faupel, Mark. PY - 2007/4. Y1 - 2007/4. N2 - OBJECTIVE. This study compared the performance of cervical cytology plus human papilloma virus testing (Pap + HPV) or cervical spectroscopy (Pap + CS) for identifying high-grade cervical neoplasia in a high-risk population of women referred for colposcopy. MATERIALS AND METHODS. Each of 113 subjects underwent spectroscopy, thin-layer cytology, HPV testing, colposcopy, biopsy when indicated, and/or endocervical curettage. Evaluable data for analysis were collected for 102 of the subjects. Sensitivity and specificity were calculated for both strategies. RESULTS. Pap + HPV and Pap + CS achieved equivalent ...
We have isolated four clones of integrated human papillomavirus type 16 (HPV-16) DNA from four different primary cervical cancer specimens. All clones were found to be monomeric or dimeric forms of HPV-16 DNA with cellular flanking sequences at both ends. Analysis of the viral sequences in these clones showed that E6/E7 open reading frames and the long control region were conserved and that no region specific for the integration was detected. Analysis of the cellular flanking sequences revealed no significant homology with any known human DNA sequences, except Alu sequences, and no homology among the clones, indicating no cellular sequence specific for the integration. By probing with single-copy cellular flanking sequences from the clones, it was demonstrated that the integrated HPV-16 DNAs, with different sizes in the same specimens, shared the same cellular flanking sequences at the ends. Furthermore, it was shown that the viral sequences together with cellular flanking sequences were ...
Human Papillomavirus Infection Test - Review how anyone can, with safe natural methods, effortlessly cure HPV infections and issues, such as abnormal Pap smears and cervical dysplasia, and thereby bypass unhealthy surgery.
Although an oncogenic human papillomavirus (HPV) infection has been established as the necessary cause of cervical cancer, most HPV infections are transient and rarely progress to significant cervical lesions. Current research has focused on identifying factors associated with viral persistence and clearance. Low nutritional status might influence a womans risk of having a persistent HPV infection and progression of that infection to cervical dysplasia, or at higher levels increase the probability of clearing infections. The overall goal of this research was to determine the associations between serum carotenoid, tocopherol, and retinoic acid levels and cervical carcinogenesis among the Ludwig-McGill Cohort Study. A sub-cohort of 846 women, all of whom had HPV results available from four consecutive study visits in the first year of follow-up, had serum samples analyzed for circulating nutrients. We determined the variability of circulating retinoic acid levels over the four months in a sample ...
Genital human papillomavirus (HPV) is the most common of the STDs. There are over 40 types that can infect the genital areas of men and women, including the penis; vulva; anus; and the rectal, cervical, and vaginal linings. Genital warts (one type of HPV) are circumscribed, elevated skin lesions, usually seen on the external genitalia or near the anus. Approximately 20 million Americans are currently infected with HPV. Most persons do not realize they are infected or that they are passing the virus to their partner.. Etiology. Genital HPV is typically spread from person to person during intimate sexual contact. A pregnant woman can pass HPV to her neonate during vaginal delivery. Genital warts have a prolonged incubation period of 1 to 6 months and grow rapidly in the presence of heavy perspiration, poor hygiene, or pregnancy.. Signs and Symptoms. Most individuals with HPV do not develop symptoms. However, some types of HPV (usually known as low-risk) are the cause of genital warts. Clients ...
Background: We assessed the association of human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN) with various characteristics, CD4 count and use of combination antiretroviral therapy (cART) among HIV-positive women. Methods: Cross-sectional study of 498 HIV-positive women who underwent HPV PCR-based testing, cytology, and systematic cervical biopsy. Results: In all, 68.7% of women were HPV-positive, 52.6% had high-risk (hr) HPV, and 40.2% multiple type infections. High-risk human papillomavirus-positivity did not vary significantly by age but it was negatively associated with education level. The most frequent types in 113 CIN2/3 were HPV16 (26.5%), HPV35 (19.5%), and HPV58 (12.4%). CD4 count was negatively associated with prevalence of hrHPV (Po0.001) and CIN2/3 among non-users of cART (P¼0.013). Combination antiretroviral therapies users (X2 year) had lower hrHPV prevalence (prevalence ratio (PR) vs non-users¼0.77, 95% confidence interval (CI): 0.61-0.96) and multiple
"Papillomaviridae". ViralZone. SIB Swiss Institute of Bioinformatics. Retrieved 2015-10-10. "Togaviridae". ViralZone. SIB Swiss ... Double-stranded DNA families: three are non-enveloped (Adenoviridae, Papillomaviridae and Polyomaviridae) and two are enveloped ...
"Papillomaviridae". ViralZone. Swiss Institute of Bioinformatics. Retrieved 24 September 2020. "Polyomaviridae". ViralZone. ...
"ICTV Report Papillomaviridae". ICTV Report Papillomaviridae Viralzone: Zetapapillomavirus. ... Zetapapillomavirus is a genus of viruses, in the family Papillomaviridae. Horses serve as natural hosts. There is currently ... Group: dsDNA Order: Zurhausenvirales Family: Papillomaviridae Genus: Zetapapillomavirus Zetapapillomavirus 1 Viruses in ... Papillomaviridae". The Journal of General Virology. 99 (8): 989-990. doi:10.1099/jgv.0.001105. PMC 6171710. PMID 29927370. " ...
"ICTV Report Papillomaviridae". ICTV Report Papillomaviridae Viralzone: Xipapillomavirus. ... Xipapillomavirus is a genus of viruses, in the family Papillomaviridae. Bovine serve as natural hosts. There are currently five ... Group: dsDNA Order: Zurhausenvirales Family: Papillomaviridae Genus: Xipapillomavirus Xipapillomavirus 1 Xipapillomavirus 2 ... Papillomaviridae". The Journal of General Virology. 99 (8): 989-990. doi:10.1099/jgv.0.001105. PMC 6171710. PMID 29927370. " ...
CS1 maint: discouraged parameter (link) "ICTV Report Papillomaviridae". ICTV Report Papillomaviridae Viralzone: ... Gammapapillomavirus is a genus of viruses, in the family Papillomaviridae. Human serve as natural hosts. There are currently 27 ... Group: dsDNA Order: Zurhausenvirales Family: Papillomaviridae Genus: Gammapapillomavirus Gammapapillomavirus 1 ... Papillomaviridae". The Journal of General Virology. 99 (8): 989-990. doi:10.1099/jgv.0.001105. PMC 6171710. PMID 29927370. " ...
When retroviruses have integrated their own genome into the germ line, their genome is passed on to a following generation. These endogenous retroviruses (ERVs), contrasted with exogenous ones, now make up 5-8% of the human genome.[7] Most insertions have no known function and are often referred to as "junk DNA". However, many endogenous retroviruses play important roles in host biology, such as control of gene transcription, cell fusion during placental development in the course of the germination of an embryo, and resistance to exogenous retroviral infection. Endogenous retroviruses have also received special attention in the research of immunology-related pathologies, such as autoimmune diseases like multiple sclerosis, although endogenous retroviruses have not yet been proven to play any causal role in this class of disease.[8] While transcription was classically thought to occur only from DNA to RNA, reverse transcriptase transcribes RNA into DNA. The term "retro" in retrovirus refers to ...
The hepatitis envelope proteins are composed of subunits made from the viral preS1, preS2, and S genes. The L (for "large") envelope protein contains all three subunits. The M (for "medium") protein contains only preS2 and S. The S (for "small") protein contains only S. The genome portions encoding these envelope protein subuntis share both the same frame and the same stop codon (generating nested transcripts on a single open reading frame. The pre-S1 is encoded first (closest to the 5' end), followed directly by the pre-S2 and the S. When a transcript is made from the beginning of the pre-S1 region, all three genes are included in the transcript and the L protein is produced. When the transcript starts after the pro-S1 at the beginning of the pre-S2 the final protein contains the pre-S2 and S subunits only and therefore is an M protein. The smallest envelope protein containing just the S subunit is made most because it is encoded closest to the 3' end and comes from the shortest transcript. ...
Viruses in Betanodavirus are non-enveloped, with icosahedral geometries, and T=3 symmetry. The diameter is around 30 nm. Genomes are linear and segmented, bipartite, around 21.4kb in length.[8]. The crystal structure of a betanodavirus- T=3 Grouper nervous necrosis virus (GNNV)-like particle has been determined by X-ray crystallography. The virus-like particle contains 180 subunits of the capsid protein, and each capsid protein (CP) shows three major domains: (i) the N-terminal arm, an inter-subunit extension at the inner surface; (ii) the shell domain (S-domain), a jelly-roll structure; and (iii) the protrusion domain (P-domain) formed by three-fold trimeric protrusions. [10]. ...
Nucleic acid analysis suggests a very long association of the viruses with the wasps (greater than 70 million years).. Two proposals have been advanced for how the wasp/virus association developed. The first suggests that the virus is derived from wasp genes. Many parasitoids that do not use PDVs inject proteins that provide many of the same functions, that is, a suppression of the immune response to the parasite egg. In this model, the braconid and ichneumonid wasps packaged genes for these functions into the viruses-essentially creating a gene-transfer system that results in the caterpillar producing the immune-suppressing factors. In this scenario, the PDV structural proteins (capsids) were probably "borrowed" from existing viruses.. The alternative proposal suggests that ancestral wasps developed a beneficial association with an existing virus that eventually led to the integration of the virus into the wasp's genome. Following integration, the genes responsible for virus replication and the ...
Louis Pasteur was unable to find a causative agent for rabies and speculated about a pathogen too small to be detected using a microscope.[21] In 1884, the French microbiologist Charles Chamberland invented a filter (known today as the Chamberland filter or the Pasteur-Chamberland filter) with pores smaller than bacteria. Thus, he could pass a solution containing bacteria through the filter and completely remove them from the solution.[22] In 1892, the Russian biologist Dmitri Ivanovsky used this filter to study what is now known as the tobacco mosaic virus. His experiments showed that crushed leaf extracts from infected tobacco plants remain infectious after filtration. Ivanovsky suggested the infection might be caused by a toxin produced by bacteria, but did not pursue the idea.[23] At the time it was thought that all infectious agents could be retained by filters and grown on a nutrient medium - this was part of the germ theory of disease.[2] In 1898, the Dutch microbiologist Martinus ...
The Herpesvirales naming system originated in 1973 and has been elaborated considerably since. All herpesviruses described since this system was adopted have been named in accordance with it. The recommended naming system specifies that each species name consists of three parts: a first word, a second word, and finally a number. The first word should be derived from the taxon (family or subfamily) to which its primary natural host belongs. The subfamily name is used for viruses from members of the family Bovidae or from primates (the virus name ending in -ine, e.g. bovine), and the host family name for other viruses (ending in -id, e.g. equid). Human herpesviruses have been treated as an exception (human rather than hominid). Following the host-derived term, species in the family Herpesviridae, which are divided into subfamilies Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae, will have the word alphaherpesvirus, betaherpesvirus, or gammaherpesvirus added, respectively. Species in ...
Despite his other successes, Louis Pasteur (1822-1895) was unable to find a causative agent for rabies and speculated about a pathogen too small to be detected using a microscope.[1] In 1884, the French microbiologist Charles Chamberland (1851-1931) invented a filter - known today as the Chamberland filter - that had pores smaller than bacteria. Thus, he could pass a solution containing bacteria through the filter and completely remove them from the solution.[2] In 1876, Adolf Mayer, who directed the Agricultural Experimental Station in Wageningen was the first to show that what he called "Tobacco Mosaic Disease" was infectious, he thought that it was caused by either a toxin or a very small bacterium. Later, in 1892, the Russian biologist Dmitry Ivanovsky (1864-1920) used a Chamberland filter to study what is now known as the tobacco mosaic virus. His experiments showed that crushed leaf extracts from infected tobacco plants remain infectious after filtration. Ivanovsky suggested the infection ...
Papillomaviridae Genera Alphapapillomavirus. Betapapillomavirus. Gammapapillomavirus. Mupapillomavirus Nupapillomavirus HPV ...
The Birnaviridae genome encodes several proteins: Birnaviridae RNA-directed RNA polymerase (VP1), which lacks the highly conserved Gly-Asp-Asp (GDD) sequence, a component of the proposed catalytic site of this enzyme family that exists in the conserved motif VI of the palm domain of other RNA-directed RNA polymerases.[3] The large RNA segment, segment A, of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C) [4] that is processed into the major structural proteins of the virion: VP2, VP3 (a minor structural component of the virus), and into the putative protease VP4.[4] VP4 protein is involved in generating VP2 and VP3.[4] recombinant VP3 is more immunogenic than recombinant VP2.[5] Infectious pancreatic necrosis virus (IPNV), a birnavirus, is an important pathogen in fish farms. Analyses of viral proteins showed that VP2 is the major structural and immunogenic polypeptide of the virus.[6][7] All neutralizing monoclonal antibodies are specific to VP2 and bind to continuous or discontinuous ...
Infections by some strains of Papillomaviridae carry some risk of laryngeal carcinoma. People with a history of head and neck ...
The genome has features similar to both the Papillomaviridae and the Polyomaviridae. Two species have been described to date. ... exhibits genomic features of both the Papillomaviridae and Polyomaviridae. J Virol 81(24):13280-13290. ...
Papillomaviridae. *Papovaviridae (fodvorter). *Poxviridae (koppevirus). Gruppe II - Enkeltstrenget DNA-virus (ssDNA)[redigér , ...
Famili Papillomaviridae. *Famili Phycodnaviridae. *Famili Plasmaviridae. *Famili Polyomaviridae - termasuk Simian virus 40, ...
Five of the human DNA viral families have multiple kinetic classes: Poxviridae, Herpesviridae, Adenoviridae, Papillomaviridae, ...
乳突病毒科 Papillomaviridae. 二名法. human papilloma viruses. ...
... is a genus of viruses, in the family Papillomaviridae. Ruminants serve as natural hosts. There are ... Group: dsDNA Order: Unassigned Family: Papillomaviridae Genus: Deltapapillomavirus Deltapapillomavirus 1 Deltapapillomavirus 2 ...
She was awarded the 2018 IMA Gold Medal Papillomaviridae Virus "Virus Structure through a Mathematical Microscope by Reidun ...
乳头瘤病毒科 Papillomaviridae. *乳头多瘤空泡病毒科 Papovaviridae(套膜
乳头瘤病毒科 Papillomaviridae. *乳头多瘤空泡病毒科 Papovaviridae(套膜
... a DNA virus from the Papillomaviridae family. Many HPV infections cause no symptoms and 90% resolve spontaneously within two ...
... are a paraphyletic group of DNA viruses of the subfamily Firstpapillomavirinae of Papillomaviridae that are common in cattle. ...
... which was split in 1999 into the two families Papillomaviridae and Polyomaviridae. The class was established in 2019 and takes ...
Two groups of double-stranded DNA viruses with single-JRC capsids are the Papillomaviridae and Polyomaviridae, both of which ...
For certain viruses, including the families Orthomyxoviridae and Papillomaviridae, alternative splicing acts as a way to ...
A recent discovery found that Papillomaviridae, such as the human papillomavirus, use CPPs to penetrate the intracellular ...
Medicine portal Viruses portal ICTV Report Papillomaviridae Viralzone: Papillomaviridae Los Alamos National Laboratory ... Papillomaviridae is a family of non-enveloped DNA viruses whose members are known as papillomaviruses. Several hundred species ... 2] de Villiers, E.M., Bernard, H.U., Broker, T., Delius, H. and zur Hausen, H. Index of Viruses - Papillomaviridae (2006). In: ... Papillomaviridae description In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University ...
Papillomaviridae er en virusfamilie der tilhører gruppen af dobbeltstrenget DNA-virus (gruppe I, dsDNA). ... Papillomaviridae familien har 16 slægter[3] *Alphapapillomavirus *human papillomavirus - 2, 6, 7, 10, 16, 18, 26, 32, 34, 53, ... Hentet fra "https://da.wikipedia.org/w/index.php?title=Papillomaviridae&oldid=10714953" ...
Papillomaviridae. From MicrobeWiki, the student-edited microbiology resource. Revision as of 13:45, 22 June 2006 by Chochu444. ... root; Viruses; dsDNA viruses, no RNA stage; Papillomaviridae; Papillomavirus Species. Human papillomavirus, Bovin ... Retrieved from "https://microbewiki.kenyon.edu/index.php?title=Papillomaviridae&oldid=4424" ...
What is Papillomaviridae? Meaning of Papillomaviridae medical term. What does Papillomaviridae mean? ... Looking for online definition of Papillomaviridae in the Medical Dictionary? Papillomaviridae explanation free. ... redirected from Papillomaviridae). Also found in: Dictionary, Wikipedia.. Related to Papillomaviridae: Papillomaviruses ... The family Papillomaviridae comprises a highly diverse collection of more than 180 viruses, and more than 100 types of Human ...
root; Viruses; dsDNA viruses, no RNA stage; Papillomaviridae; Papillomavirus Species. Human papillomavirus, Bovin ... Difference between revisions of "Papillomaviridae". From MicrobeWiki, the student-edited microbiology resource ... Retrieved from "https://microbewiki.kenyon.edu/index.php?title=Papillomaviridae&oldid=4423" ...
Papillomaviridae - General Characteristics Flashcards Preview Virology Orange , Papillomaviridae - General Characteristics , ...
"Papillomaviridae" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Papillomaviridae" by people in UAMS Profiles by year, and ... Below are the most recent publications written about "Papillomaviridae" by people in Profiles over the past ten years. ... whether "Papillomaviridae" was a major or minor topic of these publications. To see the data from this visualization as text, ...
Members of this genus are associated with genital lesions in cetaceans. There is evidence for (intra-genus) recombination. Members of this genus lack an E7 ORF.. ...
Putative novel PV genome with complete genome sequence data available and being ,70% related to PVs within the genus.. Member Species. ...
title = "Evolution of the Papillomaviridae",. abstract = "Viruses belonging to the Papillomaviridae family have been isolated ... Evolution of the Papillomaviridae. / Van Doorslaer, Koenraad.. In: Virology, Vol. 445, No. 1-2, 01.10.2013, p. 11-20.. Research ... Fingerprint Dive into the research topics of Evolution of the Papillomaviridae. Together they form a unique fingerprint. * ... Evolution of the Papillomaviridae. In: Virology. 2013 ; Vol. 445, No. 1-2. pp. 11-20. ...
candyswift234 added text to "Q&As About Creative Biolabs" on "Papillomaviridae".. Creative Biolabs is specialized in providing ... candyswift234 added text to "World Famous Biotechnology Companies" on "Papillomaviridae".. Companies in the Field of Molecular ... candyswift234 added text to "Top 5 Antibody Humanization Service Providers in the Antibody Market" on "Papillomaviridae". ... candyswift234 added text to "Can Cancer be Cured in the Near Future? (II)" on "Papillomaviridae". ...
Papillomaviridae. In: Concise Review of Veterinary Virology Author(s):. Carter G.R. and ...
Cancer de esofag esofagian : stadii Cancerul de esofag poate cancerul esofagian operat mai multe stadii: -stadiul 0-există celule anormale în mucoasă, dar acestea nu sunt încă maligne; -stadiul 1-celulele maligne sunt localizate doar în mucoasă; -stadiul 2- celulele maligne se găsesc şi în stratul muscular; cancerul esofagian operat plus, pot afecta noduli limfatici; -stadiul 3- cancerul de esofag este extins până spre exteriorul esofagului şi poate afecta cancerul esofagian operat alte ţesuturi şi organe din vecinătate; -stadiul 4- cancerul este extins şi în alte organe din corp, dar şi în noduli la distanţă. Enterobius vermicularis phylum Cancer de esofag esofagian : cauze, simptome, tratament Endometrial cancer msi După un consult general şi o evaluarea a stării generale de sănătate, medicul gastroenterolog ar putea cancerul cancerul esofagian operat operat o serie de analize de sânge şi de investigaţii suplimentare. Hpv impfung vor und nachteile papiloma
... colului uterin papillomaviridae history anusului.. Number of biological children identified in the multigeneration register ...
When retroviruses have integrated their own genome into the germ line, their genome is passed on to a following generation. These endogenous retroviruses (ERVs), contrasted with exogenous ones, now make up 5-8% of the human genome.[7] Most insertions have no known function and are often referred to as "junk DNA". However, many endogenous retroviruses play important roles in host biology, such as control of gene transcription, cell fusion during placental development in the course of the germination of an embryo, and resistance to exogenous retroviral infection. Endogenous retroviruses have also received special attention in the research of immunology-related pathologies, such as autoimmune diseases like multiple sclerosis, although endogenous retroviruses have not yet been proven to play any causal role in this class of disease.[8] While transcription was classically thought to occur only from DNA to RNA, reverse transcriptase transcribes RNA into DNA. The term "retro" in retrovirus refers to ...
The hepatitis envelope proteins are composed of subunits made from the viral preS1, preS2, and S genes. The L (for "large") envelope protein contains all three subunits. The M (for "medium") protein contains only preS2 and S. The S (for "small") protein contains only S. The genome portions encoding these envelope protein subuntis share both the same frame and the same stop codon (generating nested transcripts on a single open reading frame. The pre-S1 is encoded first (closest to the 5 end), followed directly by the pre-S2 and the S. When a transcript is made from the beginning of the pre-S1 region, all three genes are included in the transcript and the L protein is produced. When the transcript starts after the pro-S1 at the beginning of the pre-S2 the final protein contains the pre-S2 and S subunits only and therefore is an M protein. The smallest envelope protein containing just the S subunit is made most because it is encoded closest to the 3 end and comes from the shortest transcript. ...
2. Member of the family Papillomaviridae 3. HPV causes plantar warts, genital warts, and flat warts. Some HPVs are associated ...
Creșterea excesivă papillomaviridae symptoms părului Respect religia, cancerul de colon se ia nu- mi place cand aceasta ... Papillomaviridae doencas Tipurile HPV 16 şi 18 au fost papillomaviridae symptoms papiloma virus humano mai frecvente la scară ... Papillomaviridae doencas papillomaviridae doencas del papiloma humano" în română Majoritatea femeilor infectate cu HPV cu risc ... Papillomaviridae doencas peste de tulpini descoperite în momentul actual, afecțiunile acestui papillomaviridae doencas pot fi ...
Viruses; dsDNA viruses, no RNA stage; Papillomaviridae; Alphapapillomavirus. Genomic context Go to the top of the page Help ...
Papillomaviridae HPV types 2, 16, 18, 33. humans. warts, cervical and other cancers. ...
Family Papillomaviridae Family Parvoviridae TT Virus: A Newly Described Human Virus Further Reading The Plus-Strand RNA Viruses ...
Family Papillomaviridae 343. Family Polyomaviridae 347. Family Parvoviridae 349. Family Iridoviridae 353 ...
Papillomaviridae (infectious agent). Papillomavirus, any of a subgroup of viruses belonging to the family Papillomaviridae that ... Papillomavirus, any of a subgroup of viruses belonging to the family Papillomaviridae that infect birds and mammals, causing ... Papillomavirus, any of a subgroup of viruses belonging to the family Papillomaviridae that infect birds and mammals, causing ... Papovavirus, any virus in the families Papillomaviridae and Polyomaviridae. Papovaviruses are responsible for a variety of ...
Papillomaviridae. en. dc.subject.mesh. Papillomavirus Infections. en. dc.subject.mesh. Clinical Laboratory Techniques. en. ...
Papillomaviridae * Proteinase Inhibitory Proteins, Secretory * Proteins / analysis * Transforming Growth Factor beta / analysis ...
Papillomaviridae. Genus. Alphapapillomavirus. Genus. Betapapillomavirus. Genus. Gammapapillomavirus. Genus. Deltapapillomavirus ...
Papillomaviridae. en. dc.subject.mesh. Clinical Laboratory Techniques. en. dc.subject.other. Communicable Diseases and their ...
Papillomaviridae * Papillomavirus Infections / pathology * Papillomavirus Infections / virology* * Time Factors * Tumor Virus ...
"Papillomaviridae". ViralZone. SIB Swiss Institute of Bioinformatics. Retrieved 2015-10-10. "Togaviridae". ViralZone. SIB Swiss ... Double-stranded DNA families: three are non-enveloped (Adenoviridae, Papillomaviridae and Polyomaviridae) and two are enveloped ...
Papillomaviridae and Polyomaviridae 12. Parvoviridae 13. Circoviridae 14. Retroviridae 15. Reoviridae 16. Birnaviridae 17. ...
  • All PVs form the family Papillomaviridae, which is distinct from the Polyomaviridae thus eliminating the term Papovaviridae. (wikipedia.org)
  • Papillomaviridae and Polyomaviridae 12. (barnesandnoble.com)
  • Double-stranded DNA families: three are non-enveloped (Adenoviridae, Papillomaviridae and Polyomaviridae) and two are enveloped (Herpesviridae and Poxviridae). (wikipedia.org)
  • The "normal viral flora'' found stems from seven families: Herpesviridae, Polyomaviridae, Papillomaviridae, Adenoviridae (common cold and pneumonia causing), Anelloviridae, Parvoviridae and Circoviridae. (boston.com)
  • Papillomaviridae er en virusfamilie der tilhører gruppen af dobbeltstrenget DNA - virus (gruppe I, dsDNA). (wikipedia.org)
  • HPV er en lille virus med en størrele på omkring 60 nm uden membrankappe og men en kapsid af 72 pentamerer, der indeholder et enkelt molekyle af cirkulært dsDNA, dvs. (wikipedia.org)
  • Papillomaviridae is a family of non-enveloped DNA viruses whose members are known as papillomaviruses. (wikipedia.org)
  • Viruses belonging to the Papillomaviridae family have been isolated from a variety of mammals, birds and non-avian reptiles. (elsevier.com)
  • Gammapapillomavirus is a genus of viruses, in the family Papillomaviridae. (wikipedia.org)
  • The Papillomaviridae is a family of small, non-enveloped viruses with double-stranded DNA genomes of 5 748 to 8 607 bp. (microbiologyresearch.org)
  • Human Papillomaviruses (HPV) are members of papillomaviridae family a group of more than 150 related viruses. (openpr.com)
  • Essentially nothing is known about these mechanisms for other nonenveloped viruses, including Papillomaviridae . (asm.org)
  • Persistent viruses belong to a number of viral families, including the RNA viruses (Retroviridae and Paramyxoviridae) and DNA viruses (Hepadnaviridae, Herpesviridae, Papillomaviridae). (pasteur.fr)
  • The PapillomaVirus Episteme (PaVE) provides highly organized and curated papillomavirus genomics information and tools to the scientific community for research on the Papillomaviridae family of viruses. (nih.gov)
  • Papillomaviruses (PVs) are small double-stranded DNA viruses (family Papillomaviridae ) that infect many different vertebrate species ( 12 ). (asm.org)
  • any of a subgroup of viruses belonging to the family Papillomaviridae that infect birds and mammals, causing warts (papillomas) and other benign tumours, as well as malignant cancers of the genital tract and the uterine cervix in humans. (britannica.com)
  • Papillomavirus viral replication HPV schistosomiasis meaning in hindi şi ale tipuri oncogene precum 31, 39, 51, 52, 56, 58 şi 59, au avut o prevalenţă similară şi au făcut parte din tipurile cele mai întâlnite după HPV Femeile infectate cu un tip de HPV dat papillomaviridae doencas fi co- infectate sau infectate ulterior cu alte papillomaviridae symptoms care pot cauza leziuni cervicale. (imidaruiesc-ziuacadou.ro)
  • HPV belongs to the family Papillomaviridae and is a small, nonenveloped DNA virus having diameter of 52-55 nm. (hindawi.com)
  • Human papillomavirus (HPV) is a non-enveloped deoxyribonucleic acid (DNA) virus belonging to the family Papillomaviridae . (dovepress.com)
  • HPVs are from the family Papillomaviridae, which to date contains 29 genera formed by 189 papillomavirus types. (omicsonline.org)
  • It is caused by the papillomavirus, or papillomavirus, of the Papillomaviridae family. (countryfairs.info)
  • Detection of the prototype of a potential novel genus in the family Papillomaviridae in association with canine epidermodysplasia verruciformis. (uzh.ch)
  • Kaneki Cancer Cell - HD AMV Cells at work Cancer Best Moments cancer cervical lymph nodes Treatment for papilloma on foot detoxifiere andreas moritz, como reconocer el virus del papiloma humano en hombres hpv and esophagus. (beautyboutiquesalon.ro)
  • Implicarea genomului papiloma virusului uman hpv în oncogeneza cancerului cervical Papillomaviridae symptoms Cancer-related fatigue is one of the most frequent symptoms reported by patients, in all stages of the papillomaviridae symptoms. (imidaruiesc-ziuacadou.ro)
  • Papillomaviridae" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • Members of the Papillomaviridae primarily infect mucosal and keratinised epithelia, and have been isolated from fish, reptiles, birds and mammals. (microbiologyresearch.org)
  • Papilloma breast infection virus de papiloma en el ano, pancreatic cancer questions for oncologist cancer laringe histologia. (beautyboutiquesalon.ro)
  • Papillomaviridae doencas papillomaviridae doencas del papiloma humano" în română Majoritatea femeilor infectate cu HPV cu risc crescut nu dezvoltă cancer datorită faptului că majoritatea infecţiilor au o durată scurtă de viaţă şi virusul se elimină de obicei spontan în decurs de 2 papillomaviridae symptoms. (imidaruiesc-ziuacadou.ro)
  • numai o mică parte din aceste papillomaviridae symptoms cronice evoluează către precancer iar din acestea , chiar şi mai puţine vor progresa către cancer invaziv. (imidaruiesc-ziuacadou.ro)
  • This graph shows the total number of publications written about "Papillomaviridae" by people in UAMS Profiles by year, and whether "Papillomaviridae" was a major or minor topic of these publications. (uams.edu)
  • Below are the most recent publications written about "Papillomaviridae" by people in Profiles over the past ten years. (uams.edu)
  • Da HPV kan forårsage kræft betegnes den som en oncogen virus eller oncovirus . (wikipedia.org)
  • Dette inaktiverer den integrerede virus, men kan give værtscellen en replikativ fordel, der undertiden fører til ondartede tumorer. (wikipedia.org)
  • Papillomaviridae doencas Tipurile HPV 16 şi 18 au fost papillomaviridae symptoms papiloma virus humano mai frecvente la scară mondială, HPV 16 fiind tipul cel mai întâlnit în toate regiunile. (imidaruiesc-ziuacadou.ro)
  • Prevalenţa HPV cea mai ridicată la bărbaţi s-a înregistrat în Africa , în timp ce prevalenţa cea mai scăzută a papillomaviridae symptoms virus s - a observant la bărbaţii din regiunea Asia - Pacific. (imidaruiesc-ziuacadou.ro)
  • Traducere "virus del papiloma humano" în română Sursa Virusurile din familia virusurilor papiloma afecteaza si alte specii mai papillomaviridae symptoms iepuri si vaci. (imidaruiesc-ziuacadou.ro)
  • Numărul de decese cauzate de cancerul de col uterin în întreaga lume hpv papiloma virus humano anul este estimat la Papillomaviridae symptoms de depistare implementate corespunzător contribuie la rata scăzută a mortalităţii observată în anumite ţări. (imidaruiesc-ziuacadou.ro)
  • En biologisk virus består af et genom af DNA eller RNA og et antal enzymer, der er indlejret i en proteinkappe (kaldet en kapsid ), eventuelt omkrandset af membrankappe . (wikipedia.org)
  • Virus kan ikke formere sig alene, men overtager i stedet for en værtscelle og underkaster værtscellens molekylære maskineri for at fremstille kopier af sig selv og således producere den næste generation. (wikipedia.org)
  • Derfor bliver virus typisk ikke betragtet som levende organismer, fordi de alene ikke kan formere sig eller lave stofskifte , men kræver en vært . (wikipedia.org)
  • Dog har nye genetiske undersøgelser ændret på denne opfattelse, da det har vist sig at virus nedstammer fra en fælles stamform med moderne celler og har været en faktor, der har præget evolutionen . (wikipedia.org)
  • Virus består af et genom og nogle gange et par enzymer , der er indlejret i en proteinkappe (kaldet en kapsid ), eventuelt omkranset af membrankappe (en lipid-membran, eng. (wikipedia.org)
  • Virus kan ikke formere sig alene, men overtager i stedet for en værtscelle, dvs. (wikipedia.org)
  • Determinar la contribución relativa de los diferentes genotipos de virus de los papilomas humanos (VPH) conocidos como de alto riesgo para la aparición de cáncer cervicouterino en Trinidad. (scielosp.org)
  • Înțelesul "papillomavirus" în dicționarul Engleză Papillomaviridae symptoms Înțelesul "papillomavirus" în dicționarul Engleză Human papillomavirus symptoms throat, Account Options Conținutul Human Papillomavirus - HPV - Nucleus Health Apasă pentru a vedea definiția originală «papillomavirus» în dicționarul Engleză dictionary. (fabricaspiridusilor.ro)