Pancreatic neoplasms. Medical search

Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)

A greasy substance with a smoky odor and burned taste created by high temperature treatment of BEECH and other WOOD; COAL TAR; or resin of the CREOSOTE BUSH. It contains CRESOLS and POLYCYCLIC AROMATIC HYDROCARBONS which are CARCINOGENS. It has been widely used as wood preservative and in PESTICIDES and had former use medicinally in DISINFECTANTS; LAXATIVES; and DERMATOLOGIC AGENTS.

Small oviparous fishes in the family Cyprinodontidae, usually striped or barred black. They are much used in mosquito control.

Surgical removal of the pancreas. (Dorland, 28th ed)

A true cyst of the PANCREAS, distinguished from the much more common PANCREATIC PSEUDOCYST by possessing a lining of mucous EPITHELIUM. Pancreatic cysts are categorized as congenital, retention, neoplastic, parasitic, enterogenous, or dermoid. Congenital cysts occur more frequently as solitary cysts but may be multiple. Retention cysts are gross enlargements of PANCREATIC DUCTS secondary to ductal obstruction. (From Bockus Gastroenterology, 4th ed, p4145)

Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.

A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)

Conducting a fine needle biopsy with the aid of ENDOSCOPIC ULTRASONOGRAPHY.

An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)

A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.

Ultrasonography of internal organs using an ultrasound transducer sometimes mounted on a fiberoptic endoscope. In endosonography the transducer converts electronic signals into acoustic pulses or continuous waves and acts also as a receiver to detect reflected pulses from within the organ. An audiovisual-electronic interface converts the detected or processed echo signals, which pass through the electronics of the instrument, into a form that the technologist can evaluate. The procedure should not be confused with ENDOSCOPY which employs a special instrument called an endoscope. The "endo-" of endosonography refers to the examination of tissue within hollow organs, with reference to the usual ultrasonography procedure which is performed externally or transcutaneously.

A benign tumor of the pancreatic ISLET CELLS. Usually it involves the INSULIN-producing PANCREATIC BETA CELLS, as in INSULINOMA, resulting in HYPERINSULINISM.

Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.

An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)

A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)

A malignant epithelial tumor with a glandular organization.

INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.

Tomography using x-ray transmission and a computer algorithm to reconstruct the image.

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Neoplasms containing cyst-like formations or producing mucin or serum.

Tumors or cancer of the SKIN.

Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.

Tumors or cancers of the KIDNEY.

Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.

Tumors or cancer of the THYROID GLAND.

Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.

DNA present in neoplastic tissue.

Tumors or cancer of the LUNG.

Tumors or cancer of the PAROTID GLAND.

A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)

Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.

Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.

Tumors or cancer of the APPENDIX.

Tumors or cancer of the LIVER.

A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.

Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.

Tumors or cancer of the ENDOCRINE GLANDS.

Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.

Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.

Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.

Tumors or cancer of the EYE.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Tumors or cancer of the NOSE.

Tumors or cancer of the SALIVARY GLANDS.

Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.

Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.

Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.

Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.

A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)

A benign epithelial tumor with a glandular organization.

Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.

Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

Tumors or cancer of the UTERUS.

Tumors or cancer of the INTESTINES.

Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.

Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.

Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.

A general term for various neoplastic diseases of the lymphoid tissue.

Tumors or cancer located in bone tissue or specific BONES.

Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.

Neoplasms composed of more than one type of neoplastic tissue.

Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.

Tumors or cancer of the MANDIBLE.

A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)

Tumors or cancer of the BILE DUCTS.

Ability of neoplasms to infiltrate and actively destroy surrounding tissue.

Tumors or cancer of the THYMUS GLAND.

Tumors or cancer of the SPLEEN.

Rational sequence of tests for pancreatic function. (1/9206)

Of 144 patients with suspected pancreatic disease in whom a 75Se-selenomethionine scan was performed, endoscopic retrograde pancreatography (ERP) was successful in 108 (75%). The final diagnosis is known in 100 patients and has been compared with scan and ERP findings. A normal scan reliably indicated a normal pancreas, but the scan was falsely abnormal in 30%. ERP distinguished between carcinoma and chronic pancreatitis in 84% of cases but was falsely normal in five patients with pancreatic disease. In extrahepatic biliary disease both tests tended to give falsely abnormal results. A sequence of tests to provide a rapid and reliable assessment of pancreatic function should be a radio-isotope scan, followed by ERP if the results of the scan are abnormal, and a Lundh test if the scan is abnormal but the findings on ERP are normal. (+info)

Diphtheria toxin effects on human cells in tissue culture. (2/9206)

HeLa cells exposed to a single sublethal concentration of diphtheria toxin were found to have diminished sensitivity when subsequently reexposed to the toxin. Three cells strains exhibiting toxin resistance were developed. In the cells that had previously been exposed to toxin at 0.015 mug/ml, 50% inhibition of protein synthesis required a toxin concentration of 0.3 mug/ml, which is more than 10 times that required in normal HeLa cells. There appears to be a threshold level of diphtheria toxin action. Concentrations of toxin greater than that required for 50% inhibition of protein synthesis (0.01 mug/ml) are associated with cytotoxicity, whereas those below this concentration may not be lethal. Several established human cell lines of both normal and neoplastic origin were tested for their sensitivity to the effects of the toxin. No special sensitivity was observed with the cells of tumor origin. Fifty % inhibition of protein synthesis of HeLa cells was achieved with diphtheria toxin (0.01 mug/ml) as compared to the normal human cell lines tested (0.03 and 0.5 mug/ml) and a cell line derived from a human pancreatic adenocarcinoma (0.2 mug/ml). A human breast carcinoma cell line showed a maximum of 45% inhibition of protein synthesis. This required a diphtheria toxin concentration of 5 mug/ml. These results suggest that different human cell lines show wide variation in their sensitivity to the toxin. (+info)

Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells. (3/9206)

CTGF is an immediate early growth responsive gene that has been shown to be a downstream mediator of TGFbeta actions in fibroblasts and vascular endothelial cells. In the present study hCTGF was isolated as immediate early target gene of EGF/TGFalpha in human pancreatic cancer cells by suppression hybridization. CTGF transcripts were found in 13/15 pancreatic cancer cell lines incubated with 10% serum. In 3/7 pancreatic cancer cell lines EGF/TGFalpha induced a significant rise of CTGF transcript levels peaking 1-2 h after the start of treatment. TGFbeta increased CTGF transcript levels in 2/7 pancreatic cancer cell lines after 4 h of treatment and this elevation was sustained after 24 h. Only treatment with TGFbeta was accompanied by a parallel induction of collagen type I transcription. 15/19 human pancreatic cancer tissues were shown to overexpress high levels of CTGF transcripts. CTGF transcript levels in pancreatic cancer tissues and nude mouse xenograft tumors showed a good correlation to the degree of fibrosis. In situ hybridization and the nude mouse experiments revealed that in pancreatic cancer tissues, fibroblasts are the predominant site of CTGF transcription, whereas the tumor cells appear to contribute to a lesser extent. We conclude that CTGF may be of paramount importance for the development of the characteristic desmoplastic reaction in pancreatic cancer tissues. (+info)

Detection of liver metastases from pancreatic cancer using FDG PET. (4/9206)

We evaluated the potential of the glucose analog [18F]fluorodeoxyglucose (FDG) as a PET tracer for the hepatic staging in 168 patients designated for resective pancreatic surgery. METHODS: Metastatic liver disease was confirmed or excluded during surgery or with CT follow-up for at least 6 mo. Proven metastases were then retrospectively identified on preoperative CT (gold standard). Hepatic PET scans of all patients were interpreted blindly. Any focal FDG uptake was considered malignant. Both proven hepatic metastases and suspicious hepatic PET lesions were then compared, lesion by lesion, with CT. Standardized uptake values (SUV) and tumor-to-liver ratios (T/L) were determined for the most intense lesion of each patient. RESULTS: Sensitivity of FDG PET was 68% (15 of 22 patients). The lesion detection rate was 97% (28 of 29 metastases) for lesions >1 cm and 43% (16 of 37 metastases) for lesions < or = 1 cm. Specificity was 95% (138 of 146 patients). Six of eight patients with false-positive results had marked intrahepatic cholestasis (versus 3 of 15 patients with true-positive lesions), one had an infrahepatic abscess and one had a right basal pulmonary metastasis. The SUV and T/L were 4.6+/-1.4 and 2.3+/-1.1, respectively, for malignant lesions and 4.1+/-1.5 and 1.9+/-0.3, respectively, for false-positive lesions and therefore are of limited value. CONCLUSION: FDG PET provides reliable hepatic staging for lesions >1 cm. False-positive results are associated with the presence of marked intrahepatic cholestasis. For lesions < or = 1 cm, FDG PET can define malignancy in 43% of suspicious CT lesions in the absence of dilated bile ducts. (+info)

Intensive weekly chemotherapy is not effective in advanced pancreatic cancer patients: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD). (5/9206)

Twenty-two patients, with locally advanced unresectable and/or metastatic pancreatic carcinoma, received weekly administration of cisplatin 40 mg m(-2), 5-fluorouracil 500 mg m(-2), epidoxorubicin 35 mg m(-2), 6S stereoisomer of leucovorin 250 mg m(-2) and glutathione 1.5 mg m(-2), supported by a daily administration of lenograstim at a dose of 5 microg kg(-1). Nineteen patients were men and three were women. Median age was 63 years (range 47-70). At study entry, pain was present in 15 out of 22 patients (68%) with a mean value of Scott-Huskisson scale of 27.6+/-23.8, whereas a weight loss >10% was present in 15 patients. After eight weekly treatments, three partial responses were achieved for a response rate of 13% (95% CI 0-26%), five patients had stable disease and 14 progressed on therapy. Pain was present in 9 out of 22 patients (40%) with a mean value of Scott-Huskisson scale of 12.3+/-18.4. Eight patients (36%) (three partial response and five stable disease) had a positive weight change. Toxicity was mild: WHO grade III or IV toxicity was recorded in terms of anaemia in 7 out of 188 cycles (3.7%), of neutropenia in 9 out of 188 cycles (4.7%) and of thrombocytopenia in 3 out of 188 cycles (1.5%). Median survival of all patients was 6 months. The outcome of this intensive chemotherapy regimen does not support its use in pancreatic cancer. (+info)

Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results. (6/9206)

Fourteen patients with metastatic pancreatic adenocarcinoma were treated with the long-acting somatostatin (SST) analogue lanreotide. No objective response was obtained, and the median survival was 4 months (range 1.8-7 months). Pancreatic cancer could not be visualized by means of SST-receptor (R) scintigraphy in our patients. In vitro data also demonstrated absence of SSTR2 expression, suggesting pancreatic cancer not to be a potential target for treatment with SST analogues. (+info)

Gallstones, cholecystectomy and risk of cancers of the liver, biliary tract and pancreas. (7/9206)

To examine the association between gallstones and cholecystectomy, we conducted a nationwide population-based cohort study in Denmark. Patients with a discharge diagnosis of gallstones from 1977 to 1989 were identified from the Danish National Registry of Patients and followed up for cancer occurrence until death or the end of 1993 by record linkage to the Danish Cancer Registry. Included in the cohort were 60 176 patients, with 471 450 person-years of follow-up. Cancer risks were estimated by standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) stratified by years of follow-up and by cholecystectomy status. Among patients without cholecystectomy, the risks at 5 or more years of follow-up were significantly elevated for cancers of liver (SIR = 2.0, CI = 1.2-3.1) and gallbladder (SIR = 2.7, CI = 1.5-4.4) and near unity for cancers of extrahepatic bile duct (SIR = 1.1), ampulla of Vater (SIR = 1.0) and pancreas (SIR = 1.1). The excess risk of liver cancer was seen only among patients with a history of hepatic disease. Among cholecystectomy patients, the risks at 5 or more years of follow-up declined for cancers of liver (SIR = 1.1) and extrahepatic bile duct (SIR = 0.7), but were elevated for cancers of ampulla of Vater (SIR = 2.0, CI = 1.0-3.7) and pancreas (SIR = 1.3, CI = 1.1-1.6). These findings confirm that gallstone disease increases the risk of gallbladder cancer, whereas cholecystectomy appears to increase the risk of cancers of ampulla of Vater and pancreas. Further research is needed to clarify the carcinogenic risks associated with gallstones and cholecystectomy and to define the mechanisms involved. (+info)

Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms. (8/9206)

Endocrine pancreatic tumors (EPT) and neuroendocrine tumors (NET) occur sporadically and rarely in association with multiple endocrine neoplasia type 1 (MEN1). We analyzed the frequency of allelic deletions and mutations of the recently identified MEN1 gene in 53 sporadic tumors including 30 EPT and 23 NET (carcinoids) of different locations and types. Allelic deletion of the MEN1 locus was identified in 18/49 (36.7%) tumors (13/30, 43.3% in EPT and 5/19, 26.3% in NET) and mutations of the MEN1 gene were present in 8/52 (15.3%) tumors (4/30 (13.3%) EPT and 4/22 (18.1%) NET). The somatic mutations were clustered in the 5' region of the coding sequence and most frequently encompassed missense mutations. All tumors with mutations exhibited a loss of the other allele and a wild-type sequence of the MEN1 gene in nontumorous DNA. In one additional patient with a NET of the lung and no clinical signs or history of MEN1, a 5178-9G-->A splice donor site mutation in intron 4 was identified in both the tumor and blood DNA, indicating the presence of a thus far unknown MEN1 syndrome. In most tumor groups the frequency of allelic deletions at 11q13 was 2 to 3 times higher than the frequency of identified MEN1 gene mutations. Some tumor types, including rare forms of EPT and NET of the duodenum and small intestine, exhibited mutations more frequently than other types. Furthermore, somatic mutations were not restricted to foregut tumors but were also detectable in a midgut tumor (15.2% versus 16.6%). Our data indicate that somatic MEN1 gene mutations contribute to a subset of sporadic EPT and NET, including midgut tumors. Because the frequency of mutations varies significantly among the investigated tumor subgroups and allelic deletions are 2 to 3 times more frequently observed, factors other than MEN1 gene inactivation, including other tumor-suppressor genes on 11q13, may also be involved in the tumorigenesis of these neoplasms. (+info)

... (MCN) is a type of cystic lesion that occurs in the pancreas. Amongst individuals ... Intraductal papillary mucinous neoplasm Pancreatic serous cystadenoma Elta, GH; Enestvedt, BK; Sauer, BG; Lennon, AM (April ... "Pancreatic mucinous cystic neoplasm defined by ovarian stroma: demographics, clinical features, and prevalence of cancer". ... The diagnosis of pancreatic MCN is typically achieved with imaging. If the results of imaging (CT/MRI) are unclear, then ...

https://en.wikipedia.org/wiki/Pancreatic_mucinous_cystic_neoplasm

Pancreatic Neoplasms, November 2018". expertscape.com. November 2018. Retrieved 2018-11-26. "Home". halstedthedocumentary.org ... He is a world expert on pancreatic cancer. Hruban received his undergraduate degree from the University of Chicago, and his ... In November 2018, Expertscape recognized him as one of the world's foremost experts in pancreatic cancer. He also produced an ... He is currently Director of the Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins, and Baxley Professor and ...

https://en.wikipedia.org/wiki/Ralph_H._Hruban

"Expertscape: Pancreatic Neoplasms, November 2018". expertscape.com. November 2018. Retrieved 2018-11-26. Scholia has an author ... He has received multiple awards, like in 2016 the Lifetime Achievement Award of the European Pancreatic Club (EPC), in 2020 the ... His surgical focus is on hepatobiliary, colorectal, and pancreatic surgery and transplant surgery. As a surgeon, he has ... Büchler as #3 in the world for expertise in Pancreatic Cancer. Deutscher Krebspreis (2021) of the German Cancer Society ...

https://en.wikipedia.org/wiki/Markus_Büchler

"Expertscape: Pancreatic Neoplasms, November 2018". Expertscape.com. November 2018. Retrieved 26 November 2018. (Use dmy dates ... In 2018, TUM was recognized as 10th in the world for expertise in Pancreatic Cancer by Expertscape. "TUM School of Medicine". ...

https://en.wikipedia.org/wiki/TUM_School_of_Medicine

"Expertscape: Pancreatic Neoplasms, November 2018". expertscape.com. November 2018. Retrieved 2018-11-26. "Best Universities In ... In November 2018 Expertscape recognized it as #9 in the world for expertise in Pancreatic Cancer. University of Tokyo was ...

https://en.wikipedia.org/wiki/University_of_Tokyo

"Expertscape: Pancreatic Neoplasms, November 2018". expertscape.com. November 2018. Retrieved 26 November 2018. Michael Proft. ( ... the world as of 2022 In November 2018 Expertscape recognized it as one of the top ten institutions in the world in pancreatic ...

https://en.wikipedia.org/wiki/Ludwig_Maximilian_University_of_Munich

Hackeng WM, Hruban RH, Offerhaus GJ, Brosens LA (2016). "Surgical and molecular pathology of pancreatic neoplasms". Diagn ...

https://en.wikipedia.org/wiki/Intraepithelial_neoplasia

By location, they include: Pancreatic mucinous cystic neoplasm. These lesions are benign, though there is a high rate of ... A mucinous cystic neoplasm is an abnormal and excessive growth of tissue (neoplasm) that typically has elements of mucin and ... Mucinous cystic neoplasms of the liver are a type of liver cancer in which tissue similar to the stroma of ovary occurs. Elta, ... v t e (All stub articles, Neoplasm stubs, Digestive system neoplasia, Hepatology, Diseases of liver, Oncology). ...

https://en.wikipedia.org/wiki/Mucinous_cystic_neoplasm

Ellis, C. T.; Barbour, J. R.; Shary, T. M.; Adams, D. B. (2010). "Pancreatic cyst: Pseudocyst or neoplasm? Pitfalls in ... Morgan, K. A.; Fontenot, B. B.; Harvey, N. R.; Adams, D. B. (2010). "Revision of anastomotic stenosis after pancreatic head ... Theruvath, T. P.; Morgan, K. A.; Adams, D. B. (2010). "Mucinous cystic neoplasms of the pancreas: How much preoperative ... Morgan, K.; Mansker, D.; Adams, D. B. (2010). "Not Just for Trauma Patients: Damage Control Laparotomy in Pancreatic Surgery". ...

https://en.wikipedia.org/wiki/David_B._Adams

... "pancreatic endocrine tumours" are neuroendocrine neoplasms that arise from cells of the endocrine (hormonal) and nervous system ... "Pathophysiology and Treatment of Pancreatic Neuroendocrine Neoplasms (PNENS): New Developments". Pathophysiology and Treatment ... are different from the mutated genes previously found in pancreatic adenocarcinoma. one in six well-differentiated pancreatic ... Pancreatic neuroendocrine tumor staging (AJCC) Stage T1 Stage T2 Stage T3 Stage T4 Involvement of nearby lymph nodes - Stage N1 ...

https://en.wikipedia.org/wiki/Pancreatic_neuroendocrine_tumor

Additionally, it has been demonstrated as an independent prognostic factor in patients with pancreatic neuroendocrine neoplasms ... "Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasms". European Journal of Endocrinology ...

https://en.wikipedia.org/wiki/MIRN21

A rare form of pancreatic neoplasm". Diagnostic Cytopathology. 43: 251-256. doi:10.1002/dc.23195. Vlachostergios, Panagiotis J ... They can arise in several parts of the body, and thus form sub-types of diseases such as stomach cancer and pancreatic cancer. ... Hepatoid tumor or hepatoid [adeno]carcinoma are terms for a number of uncommon or rare neoplasms in humans, named for a visual ... Soofi, Yousef; Kanehira, Kazunori; Abbas, Ali; Aranez, Jose; Bain, Andrew; Ylagan, Lourdes (August 2014). "Pancreatic hepatoid ...

https://en.wikipedia.org/wiki/Hepatoid_tumor

"Pancreatic ductal and acinar cell neoplasms in Carney complex: a possible new association". J Clin Endocrinol Metab. 96 (11): ... Melanocytic nevi and neoplasms, Syndromes affecting the skin, Syndromes affecting the heart, Syndromes with tumors). ... Epithelioid blue nevus List of cutaneous neoplasms associated with systemic syndromes Carney Syndrome at eMedicine Carney, J.; ...

https://en.wikipedia.org/wiki/Carney_complex

Pancreatic serous cystadenoma Solid pseudopapillary neoplasm "Intraductal Papillary Mucinous Neoplasms of the Pancreas". Johns ... Intraductal papillary mucinous neoplasm (IPMN) is a type of tumor that can occur within the cells of the pancreatic duct. IPMN ... Although intraductal papillary mucinous neoplasms are benign tumors, they can progress to pancreatic cancer. As such IPMN is ... "Pancreatic Surgery". Johns Hopkins University. Retrieved 7 September 2009. "Laproscopic Pancreatic Surgery". Johns Hopkins ...

https://en.wikipedia.org/wiki/Intraductal_papillary_mucinous_neoplasm

2006). "Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms". Cancer Biol. Ther ...

https://en.wikipedia.org/wiki/HHIP

MeSH website, tree at: "Pancreatic Neoplasms [C04.588.322.475]",[dead link] accessed 16 October 2014 "Insulinomas". The ... Pancreatic insulinoma Pancreatic insulinoma Chromogranin A Insulin immuostain Causes of hypoglycemia Metastatic Insulinoma ... Insulinoma is one of the most common types of tumours arising from the islets of Langerhans cells (pancreatic endocrine tumours ... Sometimes, angiography with percutaneous transhepatic pancreatic vein catheterization to sample the blood for insulin levels is ...

https://en.wikipedia.org/wiki/Insulinoma

The third type, pancreatic mucinous cystic neoplasm (MCN), mainly occurs in women, and may remain benign or progress to cancer ... Stage T1 pancreatic cancer Stage T2 pancreatic cancer Stage T3 pancreatic cancer Stage T4 pancreatic cancer Pancreatic cancer ... Pancreatic mucinous cystic neoplasms are a broad group of pancreas tumors that have varying malignant potential. They are being ... Small precancerous neoplasms for many pancreatic cancers are being detected at greatly increased rates by modern medical ...

https://en.wikipedia.org/wiki/Pancreatic_cancer

The last type of exocrine tumors include pancreatic mucinous cystic neoplasms, which have fluid filled cavities. These types of ... When talking about pancreatic cancers, the most common type is pancreatic adenocarcinoma, which accounts for greater than 85% ... Pancreatic tumors (Pancreatic cancer) are often broken down into exocrine or endocrine tumors. Each different type of ... Pancreatic endocrine tumors are named after the type of hormone they release. For example, an insulin-secreting tumor is ...

https://en.wikipedia.org/wiki/Pancreatic_tumor

Pancreatic cancer Pancreatic mucinous cystic neoplasm Serous cystadenoma of the pancreas Source for mentioned findings: Pitman ... "Cytological criteria of high-grade epithelial atypia in the cyst fluid of pancreatic intraductal papillary mucinous neoplasms ... Stömmer P, Kraus J, Stolte M, Giedl J (March 1991). "Solid and cystic pancreatic tumors. Clinical, histochemical, and electron ... A solid pseudopapillary tumour is a low-grade malignant neoplasm of the pancreas of papillary architecture that typically ...

https://en.wikipedia.org/wiki/Solid_pseudopapillary_tumour

The most common malignancy that can present as a pancreatic cyst is a mucinous cystic neoplasm. Cysts from 1-5 mm on CT or ... Scholten L, van Huijgevoort N, C, M, van Hooft J, E, Besselink M, G, Del Chiaro M: Pancreatic Cystic Neoplasms: Different Types ... A pancreatic cyst is a fluid filled sac within the pancreas. Causes range from benign to malignant. Pancreatic cysts can occur ... Main branch intraductal papillary mucinous neoplasms (IPMNs) are associated with dilatation of the main pancreatic duct, while ...

https://en.wikipedia.org/wiki/Pancreatic_cyst

... manifested by pancreatic neuroendocrine neoplasms (PNETs)". Surgery. 142 (6): 814-818, discussion 818.e1-2. doi:10.1016/j.surg. ... Pancreatic involvement occurs in 77% of patients with VHL. Asymptomatic cysts consist of the majority of cases. Neuroendocrine ... "Pancreatic lesions in von Hippel-Lindau disease? A systematic review and meta-synthesis of the literature". Journal of ... endolymphatic sac tumors and pancreatic neuroendocrine tumors. Life expectancy is reduced for individuals with this condition ...

https://en.wikipedia.org/wiki/Phakomatosis

This type of malignant neoplasm mimics pancreatic development at 7 weeks of gestation and tends to affect, most commonly, young ... About 0.5% to 1% of all primary malignant lung tumors are childhood tumors of the lung, making it a rare form of neoplasm. ... Retinoblastoma is a rare form of eye neoplasm (found in the retina) that is mostly found in children, being the most common ...

https://en.wikipedia.org/wiki/Blastoma

... involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms ... Xu S, Furukawa T, Kanai N, Sunamura M, Horii A (2005). "Abrogation of DUSP6 by hypermethylation in human pancreatic cancer". ... in pancreatic cancer". Cytogenetics and Cell Genetics. 82 (3-4): 156-9. doi:10.1159/000015091. PMID 9858808. S2CID 46883904. ... "Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer". The American Journal of Pathology. 162 (6): ...

https://en.wikipedia.org/wiki/DUSP6

... pancreatic neoplasm and/or pancreatic trauma. Pancreatic pseudocysts are sometimes called false cysts because they do not have ... Pancreatic pseudocysts account for approximately 75% of all pancreatic masses. Signs and symptoms of pancreatic pseudocyst ... A pancreatic pseudocyst is a circumscribed collection of fluid rich in pancreatic enzymes, blood, and non-necrotic tissue, ... Diagnosis of Pancreatic pseudocyst can be based on cyst fluid analysis: Carcinoembryonic antigen (CEA) and CA-125 (low in ...

https://en.wikipedia.org/wiki/Pancreatic_pseudocyst

... such as the intraductal papillary mucinous neoplasm and the pancreatic mucinous cystadenoma), serous cystic neoplasms are ... Ovarian serous cystadenoma Pancreatic mucinous cystadenoma Solid pseudopapillary neoplasm Jais B, Rebours V, Malleo G, Salvia R ... "Pathology of Neoplasms of the Pancreas". Johns Hopkins University. Retrieved 25 April 2010. "Pancreatic Surgery". Johns Hopkins ... mixed serous-endocrine neoplasm, and VHL-associated serous cystic neoplasm. This latter classification scheme is useful because ...

https://en.wikipedia.org/wiki/Pancreatic_serous_cystadenoma

Case report: ectopic pancreatic rest in the proximal stomach mimicking gastric neoplasms. Clin Radiol. 2007 Jun;62(6):600-2. ... When seen on upper gastrointestinal series, a pancreatic rest may appear to be a submucosal mass or gastric neoplasm. Most are ... A myoepithelial hamartoma, also known as a pancreatic rest, is ectopic pancreatic tissue found in the stomach, duodenum, or ... A hamartoma is a mostly benign, local malformation of cells that resembles a neoplasm of local tissue but is usually due to an ...

https://en.wikipedia.org/wiki/Hamartoma

Neoplasm Carbohydrate malabsorption Pancreatic cancer Polycystic ovary syndrome (PCOS) Trans fats Since hyperinsulinemia and ... Type 1 diabetes only occurs when pancreatic beta-cell function is impaired. Hyperinsulinemia can be seen in a variety of ... Adipocytes will generate triglycerides in the presence of insulin but refers to a liver condition rather than a pancreatic one ... To compensate for the increased blood glucose levels, fetal pancreatic beta cells can undergo hyperplasia. The rapid division ...

https://en.wikipedia.org/wiki/Hyperinsulinemia

IATA airport code Pancreatic mucinous cystic neoplasm, type of cystic lesion that occurs in the pancreas This disambiguation ...

https://en.wikipedia.org/wiki/MCN

Pancreatic tumors (masses) including pancreatic cancer Serous cystadenoma of the pancreas Solid pseudopapillary neoplasm ... Other pancreatic diseases include diabetes mellitus, exocrine pancreatic insufficiency, cystic fibrosis, pseudocysts, cysts, ... A pancreatic pseudocyst is a circumscribed collection of fluid rich in amylase and other pancreatic enzymes, blood and necrotic ... A pancreatic cyst is a fluid filled sac within the pancreas. They can be benign or malignant. X-ray computed tomography (CT ...

https://en.wikipedia.org/wiki/Pancreatic_disease

... benign and metastatic neoplasms (such as breast cancer, pancreatic cancer, and oral cancer), infectious conditions (such as HIV ... In a 2011 review article that examined pancreatic cancer biomarkers, Hamade and Shimosegawa concluded that clinical application ... Hamada S, Shimosegawa T (2011). "Biomarkers of pancreatic cancer". Pancreatology. 11 Suppl 2 (2): 14-9. doi:10.1159/000323479. ... March 2010). "Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer". Gastroenterology. 138 (3): 949 ...

https://en.wikipedia.org/wiki/Saliva_testing

However, p16 can be expressed in other neoplasms and in several normal human tissues. More than a third of urinary bladder SCCs ... Examples include: Pancreatic adenocarcinoma is often associated with mutations in the CDKN2A gene. Carriers of germline ... infection and neoplasms of cervical origin. The majority of SCCs of uterine cervix express p16. ... gene in pancreatic adenocarcinoma". Nature Genetics. 8 (1): 27-32. doi:10.1038/ng0994-27. PMID 7726912. S2CID 23195660. Bartsch ...

https://en.wikipedia.org/wiki/P16

Yu J, Li A, Hong SM, Hruban RH, Goggins M (February 2012). "MicroRNA alterations of pancreatic intraepithelial neoplasias". ... "miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets ...

https://en.wikipedia.org/wiki/Mir-708_microRNA_precursor_family

... neoplasm protein - Nernst equation - nerve - nerve growth factor - nerve growth factor receptor - nerve tissue protein - nerve ... pancreatic polypeptide - parathyroid hormone receptor - partial pressure - passive transport - Pauling scale - PCR - peptide - ...

https://en.wikipedia.org/wiki/Index_of_biochemistry_articles

Increased expression in pancreatic islet beta cells causes the beta form of the protein to build an aggregate structure. This ... The loss of methylation within these areas triggers an irregular cell growth, resulting in embryonic neoplasms. Numata, Shusuke ...

https://en.wikipedia.org/wiki/Neuronatin

Baranov E, Hornick JL (March 2020). "Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck ... in an individual with a pancreatic LGMS tumor (treatment regimen: ifosfamide, pirarubicin, and nedaplatin). Further studies are ...

https://en.wikipedia.org/wiki/Low-grade_myofibroblastic_sarcoma

They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... "Screening for Pancreatic Cancer". U.S. Preventive Services Task Force. 2004. Archived from the original on 21 November 2010. ... Routine screening is not recommended for bladder cancer, testicular cancer, ovarian cancer, pancreatic cancer, or prostate ... colon cancer and pancreatic cancer, a phenomenon that could be due to the presence of carcinogens in meats cooked at high ...

https://en.wikipedia.org/wiki/Cancer

CD10+ differentiates mucinous cystic neoplasms (CD10+/CK20+) from intraductal papillary mucinous neoplasm of branch duct type ( ... Chromophobe carcinoma and oncocytoma are CD10−. Pancreatic tumors Solid pseudopapillary tumours are CD10+. ... Murali R, Delprado W (2005). "CD10 immunohistochemical staining in urothelial neoplasms". Am. J. Clin. Pathol. 124 (3): 371-9. ... and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms". ...

https://en.wikipedia.org/wiki/Neprilysin

In contrast to most other cancers, adrenocortical neoplasms appear to have decreased expression of H19. To determine a possible ... "Phase 1/2a DTA-H19 in Patients With Unresentable Pancreatic Cancer". ClinicalTrials.gov. U.S. National Institutes of Health. ... ovarian cancer and pancreatic cancer. The plasmid, designated BC-819 (or DTA-H19), embodies a targeted therapy approach, in ... adrenocortical neoplasms, choriocarcinomas, hepatocellular carcinomas, bladder cancers, ovarian serous epithelial cancers, head ...

https://en.wikipedia.org/wiki/H19_(gene)

Michaud, Dominique S.; Izard, Jacques (2014). "Microbiota, Oral Microbiome, and Pancreatic Cancer". The Cancer Journal. 20 (3 ... induced Genetic/developmental disorders Specific infections Inflammatory and immune conditions Reactive processes Neoplasms ... and pancreatic cancer. A positive correlation between raised levels of glucose within the blood and the onset or progression of ...

https://en.wikipedia.org/wiki/Periodontal_disease

Articles with short description, Short description is different from Wikidata, Epidermal nevi, neoplasms, and cysts, Conditions ... pancreatic cancer, uterine cancer, stomach cancer, colon cancer, lung cancer, and human papillomavirus-associated cancers. In a ... Trichofolliculoma Spiradenoma spiradenocarcinoma List of cutaneous conditions List of cutaneous neoplasms associated with ... "Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on ...

https://en.wikipedia.org/wiki/CYLD_cutaneous_syndrome

In pancreatic cancer, radiotherapy has increased survival times for inoperable tumors. Radiation therapy is in itself painless ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ...

https://en.wikipedia.org/wiki/Radiation_therapy

... neoplasms, and cysts are skin lesions that develop from the epidermal layer of the skin. Aberrant basal cell carcinoma ... pancreatic fat necrosis, subcutaneous fat necrosis) Poland's syndrome Post-steroid panniculitis Sclerema neonatorum Sclerosing ... an overview with emphasis on the myeloid neoplasms". Chem. Biol. Interact. 184 (1-2): 16-20. doi:10.1016/j.cbi.2009.10.009. ... neoplasms invading or aberrantly present in the dermis. Acquired progressive lymphangioma (benign lymphangioendothelioma) Acral ...

https://en.wikipedia.org/wiki/List_of_skin_conditions

Gibbon-ape leukemia virus (GaLV) is an oncogenic, type C retrovirus that has been isolated from primate neoplasms, including ... patients with porcine-based liver or pancreatic xenografts, and butchers in contact with porcine tissue. GaLV Envelope Protein ... The virus was identified as the etiological agent of hematopoietic neoplasms, leukemias, and immune deficiencies within gibbons ...

https://en.wikipedia.org/wiki/Gibbon_ape_leukemia_virus

Neoplasm Metastasis Cancer Brain tumor Tse V (10 November 2009). "Brain Metastasis". Medscape. Retrieved 13 January 2010. " ... especially colorectal and pancreatic carcinoma, 3% Lymphoma, 1% Lung cancer and melanoma are most likely to present with ... Percy AK, Elveback LR, Okazaki H, Kurland LT (January 1972). "Neoplasms of the central nervous system. Epidemiologic ... the national survey of intracranial neoplasms". Neurology. 35 (2): 219-26. doi:10.1212/WNL.35.2.219. PMID 3969210. S2CID ...

https://en.wikipedia.org/wiki/Brain_metastasis

King JC, Ng TT, White SC, Cortina G, Reber HA, Hines OJ (October 2009). "Pancreatic serous cystadenocarcinoma: a case report ... Neoplasm stubs). ... with the majority of microcystic pancreatic masses representing ...

https://en.wikipedia.org/wiki/Serous_cystadenocarcinoma

"Phase I Nab-Paclitaxel Plus Gemcitabine With Proton Therapy for Locally Advanced Pancreatic Cancer (LAPC)". ClinicalTrials.gov ... Two prominent examples are pediatric neoplasms (such as medulloblastoma) and prostate cancer. Irreversible long-term side ... The following review presents the benefits of proton therapy in treating hepatocellular carcinoma, pancreatic cancer and ... Pancreatic cancer-by University of Maryland, Proton Collaborative Group (PCG) The figure at the right of the page shows how ...

https://en.wikipedia.org/wiki/Proton_therapy

"Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302". Cancer & Metabolism. 3 (1): 2. doi:10.1186/s40170- ... a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study ...

https://en.wikipedia.org/wiki/Epithelioid_sarcoma

Suzuki A, Nakauchi H, Taniguchi H (August 2004). "Prospective isolation of multipotent pancreatic progenitors using flow- ... Misago N, Narisawa Y (September 2006). "Cytokeratin 15 expression in neoplasms with sebaceous differentiation". Journal of ...

https://en.wikipedia.org/wiki/Stem_cell_marker

Memorial Sloan Kettering Cancer Center Pancreatic cancer: inoperable, or borderline resectable, locally advanced pancreatic ... such as osteoporosis or underlying neoplasm. Analogous to vertebroplasty, the purpose of sacroplasty is to provide ... Often used in the management of incurable pancreatic cancer. Often utilizes multidetector CT for image guidance. Superior ... Martin, Robert C. G. (June 2015). "Use of irreversible electroporation in unresectable pancreatic cancer". Hepatobiliary ...

https://en.wikipedia.org/wiki/Interventional_radiology

While many general surgeons are actively involved in treating patients with malignant neoplasms, the designation of "surgical ... for pancreatic cancer, and gastrectomy with extended (D2) lymphadenectomy for gastric cancer. In the United States and Canada, ...

https://en.wikipedia.org/wiki/Surgical_oncology

... liver neoplasms, experimental MeSH C04.588.274.761 - pancreatic neoplasms MeSH C04.588.274.761.249 - adenoma, islet cell MeSH ... pancreatic ductal MeSH C04.588.274.780 - peritoneal neoplasms MeSH C04.588.322.078 - adrenal gland neoplasms MeSH C04.588. ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588.274.120.250.250 - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C04)

Pancreatic tumours involve the islet cells, giving rise to gastrinomas or insulinomas. In rare cases, adrenal cortex tumours ... The MEN1 phenotype is inherited via an autosomal-dominant pattern and is associated with neoplasms of the pituitary gland, the ... Pancreatic presentations of the MEN1 phenotype may manifest as Zollinger-Ellison syndrome. MEN1 pituitary tumours are adenomas ... and ependymomas are observed neoplasms. In a study of 12 sporadic carcinoid tumors of the lung, five cases involved ...

https://en.wikipedia.org/wiki/MEN1

... pancreatic islet cells and lymphoid cells. PAX8 and other transcription factors play a role in binding to DNA and regulating ... aka Hurthle-Cell Neoplasms). Expression of PAX8 is increased in neoplastic renal tissues, Wilms tumors, ovarian cancer and ...

https://en.wikipedia.org/wiki/PAX8

"Pacritinib in Combination with Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN ... "Momelotinib Combined with Capecitabine and Oxaliplatin in Adults with Relapsed/Refractory Metastatic Pancreatic Ductal ... Gandotinib (LY-2784544) against JAK2 for myeloproliferative neoplasms. Lestaurtinib (CEP-701) against JAK2 for acute myeloid ... Stallard, J (23 July 2015). "Discovery Could Boost New Therapies for Myeloproliferative Neoplasms". Memorial Sloan Kettering ...

https://en.wikipedia.org/wiki/Janus_kinase_inhibitor

Klöppel, G; Solcia, E; Longnecker, D. S; Capella, C; Sobin, Leslie H; World Health Organization (‎Springer-Verlag, 1996)‎ ...

https://apps.who.int:80/iris/browse?authority=Pancreatic+Neoplasms&type=mesh

Klöppel, G; Solcia, E; Longnecker, D. S; Capella, C; Sobin, Leslie H; World Health Organization (‎Springer-Verlag, 1996)‎ ...

https://extranet.who.int/iris/restricted/browse?authority=Pancreatic+Neoplasms&type=mesh

Pancreatic neuroendocrine neoplasms are rare tumors of which the genetic constitution is not fully understood. In addition, ... Pancreatic Neuroendocrine Neoplasms: from Genetics to Everolimus Resistance. Publication. Publication. Pancreatische ... Vandamme, T.A.L. (2021, April 20). Pancreatic Neuroendocrine Neoplasms: from Genetics to Everolimus Resistance. Retrieved from ... Neuroendocrine neoplasms, neuroendocrine tumors, neuroendocrine tumours, everolimus, treatment resistance, tumor heterogeneity, ...

https://repub.eur.nl/pub/135471

... of all pancreatic tumors. pNENs are pathologically heterogeneous and are categorized into three groups (neuroendocrine tumor: ... Pancreatic neuroendocrine neoplasms (pNENs) are rare tumors accounting for only 1-2% ... Pancreatic neuroendocrine neoplasms (pNENs) are rare tumors accounting for only 1-2% of all pancreatic tumors. pNENs are ... Pancreatic Neuroendocrine Neoplasms: Basic Biology, Current Treatment Strategies and Prospects for the Future. Akihiro Ohmoto ...

https://www.preprints.org/manuscript/201611.0120/v1

However, its role in pancreatic neuroendocrine neoplasms (PNENs) has not been understood. In the current study, the ... Receiver operating characteristic analysis to differentiate the high grade pancreatic neuroendocrine neoplasms (PNENs) from the ... From: The associations between serum high-density lipoprotein cholesterol levels and malignant behavior in pancreatic ...

https://lipidworld.biomedcentral.com/articles/10.1186/s12944-022-01669-z/figures/2

N2 - Pancreatic cystic neoplasms are increasingly detected in the general population. Although most of these lesions are benign ... AB - Pancreatic cystic neoplasms are increasingly detected in the general population. Although most of these lesions are benign ... Pancreatic cystic neoplasms are increasingly detected in the general population. Although most of these lesions are benign, ... abstract = "Pancreatic cystic neoplasms are increasingly detected in the general population. Although most of these lesions are ...

https://pure.eur.nl/en/publications/neoplastische-cysten-van-het-pancreas

Pancreatic cancer / edited by Isidore Cohn and Paul R. Hastings. by Cohn, Isidore , Hastings, Paul Russell , International ...

https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=su:%7BPancreatic%20neoplasms%7D

Genç CG, Klümpen H-J, Denecke T, Wiedenmann B, Pavel M. Successful treatment of high-grade pancreatic neuroendocrine neoplasms ... Successful treatment of high-grade pancreatic neuroendocrine neoplasms with everolimus. Cansu G. Genç, Heinz-Josef Klümpen, ... Successful treatment of high-grade pancreatic neuroendocrine neoplasms with everolimus. / Genç, Cansu G.; Klümpen, Heinz-Josef ... Successful treatment of high-grade pancreatic neuroendocrine neoplasms with everolimus. In: Acta Oncologica. 2018 ; Vol. 57, No ...

https://research.vumc.nl/en/publications/successful-treatment-of-high-grade-pancreatic-neuroendocrine-neop

Pancreatic cancer is hard to catch early. Find out about risk factors and symptoms. ... ClinicalTrials.gov: Pancreatic Neoplasms (National Institutes of Health) Journal Articles References and abstracts from MEDLINE ... Acupuncture for Pancreatic Cancer Patients (Pancreatic Cancer Action Network) * Drugs Approved for Pancreatic Cancer (National ... General Information about Pancreatic Cancer (National Cancer Institute) Also in Spanish * Pancreatic Cancer (Genetic and Rare ...

https://medlineplus.gov/pancreaticcancer.html

Pancreatic Cancer Liver FNB Neurolysis 2 (Dr. Sahai) * Pancreatic Cancer with Involvement of the Artery and the Vein (Dr. Sahai ... Chronic Pancreatitis vs Pancreatic Cancer (Dr. Sahai) (Dr. Sahai) * Chronic Pancreatitis vs Pancreatic Cancer Large Duodenal ... EUS sampling of pancreatic mass including pathologist assessment (Dr. Sahai) * EUS sampling of suspected cholangiocarcinoma (Dr ... Chronic Pancreatitis vs Pancreatic Cancer (Dr. Giovannini) (Dr. Giovannini) * ...

https://eusvideolibrary.cookmedical.com/pancreas/pancreas_121.html

FGD4 (Frabin) Overexpression in Pancreatic Neuroendocrine Neoplasms.. Mohammad Shahid. Tarra B George. James Saller. Mohammad ... OBJECTIVE\nThe pathogenesis of pancreatic neuroendocrine tumors (PNETs) is still unclear. We propose Frabin as a new molecular ... The tissue microarray included 12 grade 1 and 3 grade 2 PNETs and 14 grade 3 pancreatic neuroendocrine carcinomas (PECAs). ...

https://researchain.net/papers/10z99z1097w99wMPAz99z0000000000001422

Concomitant Intraductal Papillary Mucinous Neoplasm in Pancreatic Ductal Adenocarcinoma Is an Independent Predictive Factor for ... Concomitant Intraductal Papillary Mucinous Neoplasm in Pancreatic Ductal Adenocarcinoma Is an Independent Predictive Factor for ... Concomitant Intraductal Papillary Mucinous Neoplasm in Pancreatic Ductal Adenocarcinoma Is an Independent Predictive Factor for ... Concomitant Intraductal Papillary Mucinous Neoplasm in Pancreatic Ductal Adenocarcinoma Is an Independent Predictive Factor for ...

https://kyushu-u.pure.elsevier.com/ja/publications/concomitant-intraductal-papillary-mucinous-neoplasm-in-pancreatic

Pancreatic Neoplasms (11) * Head & Neck Neoplasms (6) * Gynecologic Neoplasms (5) * Endocrine System Neoplasms (5) ...

https://www.sharecare.com/find-a-doctor/specialty/hematology/mn-minnesota/austin

pancreatic neoplasms (C25.-, D13.6, D13.7, D37.7),. • malnutrition (E40-E46);. e. rheumatic fever (I00-I02) or rheumatic heart ... Code to neoplasm of uncertain or unknown behavior of brain (D432). To assign the codes for the record, note that infection is ... any infectious disease classified to A000-A090, A162-B199 or B250-B64 reported as "due to" a malignant neoplasm will also be an ... b. a malignant neoplasm reported as "due to" any other disease, except human immunodeficiency virus [HIV] disease; ...

https://www.cdc.gov/nchs/nvss/manuals/2023/2a-sectioniii-2023.htm

Version 04 Chapter-09: GIT Pancreas Surgery Topic 04 ENDOCRINE PANCREATIC NEOPLASMS ... Version 04 Chapter-04: GIT Liver Surgery Topic 02 NEOPLASMS OF LIVER ...

https://dreamz-medical-edutech.teachable.com/courses/mbbs-final-year/lectures/10621778

Surgical treatment of pancreatic tumors in childhood and adolescence: Uncommon neoplasms with favorable outcome. Pancreatology ... Surgical treatment of pancreatic tumors in childhood and adolescence : Uncommon neoplasms with favorable outcome. In: ... Surgical treatment of pancreatic tumors in childhood and adolescence : Uncommon neoplasms with favorable outcome. / Marchegiani ... Surgical treatment of pancreatic tumors in childhood and adolescence: Uncommon neoplasms with favorable outcome. ...

https://moh-it.pure.elsevier.com/en/publications/surgical-treatment-of-pancreatic-tumors-in-childhood-and-adolesce

Pancreatic Neoplasms. Students, Medical. Internship and Residency. Education, Medical. Health Expenditures. Neoplasms. ... Carcinoma, Pancreatic Ductal. Hospitalization. Leukemia, Myeloid, Acute. Terminal Care. To see the data from this visualization ...

https://connects.catalyst.harvard.edu/Profiles/display/person/191360/network/researchareas/timeline

Pancreatic cancer. Pancreatic Neoplasms - blood. Pancreatic Neoplasms - immunology. Pancreatic Neoplasms - pathology. ... Carcinoma, Pancreatic Ductal - blood. Carcinoma, Pancreatic Ductal - immunology. Carcinoma, Pancreatic Ductal - pathology. Care ... Intraductal papillary mucinous neoplasms (IPMNs) are premalignant pancreatic cysts of which a subset has the potential to... ... Full title: Immunobiology and immunosurveillance in patients with intraductal papillary mucinous neoplasms (IPMNs), ...

https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1808739865

Prospective preoperative determination of mucinous pancreatic cystic neoplasms. R. Matthew Walsh, J. Michael Henderson, David P ... Dive into the research topics of Prospective preoperative determination of mucinous pancreatic cystic neoplasms. Together ...

https://scholars.uky.edu/en/publications/prospective-preoperative-determination-of-mucinous-pancreatic-cys/fingerprints/

Is it necessary to follow patients after resection of a benign pancreatic intraductal papillary mucinous neoplasm?. ... Is it necessary to follow patients after resection of a benign pancreatic intraductal papillary mucinous neoplasm?. Together ...

https://utsouthwestern.pure.elsevier.com/en/publications/is-it-necessary-to-follow-patients-after-resection-of-a-benign-pa/fingerprints/

Solid pseudopapillary neoplasm, a rare pancreatic tumor-case report ...

https://ijsurgery.com/index.php/isj/article/view/9079/5509

Pancreatic Neoplasms / genetics * Paraganglioma / blood * Paraganglioma / complications * Paraganglioma / genetics* * ...

https://pubmed.ncbi.nlm.nih.gov/22931260/?dopt=Abstract

Pancreatic Neoplasms. *Precision Medicine. *Thyroid Neoplasms. Research Interests. Oncogenic transformation requires ...

https://www.mcw.edu/departments/biochemistry/people/jong-in-park-phd

Neoplasms. Digestive System Neoplasms. Neoplasms by Site. Endocrine Gland Neoplasms. Digestive System Diseases. Pancreatic ... Pancreatic Neoplasms. Carcinoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. ... Metastatic Pancreatic Adenocarcinoma Metastatic Pancreatic Cancer Drug: Nab-Paclitaxel Drug: Gemcitabine Drug: Indoximod Phase ... Study of IDO Inhibitor in Combination With Gemcitabine and Nab-Paclitaxel in Patients With Metastatic Pancreatic Cancer. The ...

https://www.clinicaltrials.gov/show/NCT02077881

Neoplasms. Digestive System Neoplasms. Neoplasms by Site. Endocrine Gland Neoplasms. Digestive System Diseases. Pancreatic ... Pancreatic Neoplasms. Carcinoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. ... stage I pancreatic cancer. stage II pancreatic cancer. duct cell adenocarcinoma of the pancreas. ... MedlinePlus related topics: Pancreatic Cancer Vaccines Genetic and Rare Diseases Information Center resources: Pancreatic ...

https://clinicaltrials.gov/ct2/show/NCT00084383

PDAC cells invade the stroma but can also invade back into and spread via the pancreatic ducts, which has been referred to as ... is often the treatment of choice for borderline resectable and locally advanced invasive pancreatic ductal adenocarcinoma (PDAC ... Pancreatic ductal adenocarcinomas associated with intraductal papillary mucinous neoplasms (IPMNs) versus pseudo-IPMNs: ... Surgical and molecular pathology of pancreatic neoplasms. Diagn Pathol. 2016;11:47. ...

https://www.nature.com/articles/s41379-020-0572-6?error=cookies_not_supported&code=e30bf117-d8b8-4b17-8ed5-5e0971d4fcff

keywords = "MicroRNA, Pancreatic ductal adenocarcinoma, Pancreatic intraepithelial neoplasm",. author = "Yue Xue and {Abou ... MicroRNAs as diagnostic markers for pancreatic ductal adenocarcinoma and its precursor, pancreatic intraepithelial neoplasm. / ... MicroRNAs as diagnostic markers for pancreatic ductal adenocarcinoma and its precursor, pancreatic intraepithelial neoplasm. ... MicroRNAs as diagnostic markers for pancreatic ductal adenocarcinoma and its precursor, pancreatic intraepithelial neoplasm. In ...

https://www.scholars.northwestern.edu/en/publications/micrornas-as-diagnostic-markers-for-pancreatic-ductal-adenocarcin

Pancreatic-islets-neoplasms; Kidney-disorders; Kidney-damage; Bladder-cancer; Bladder-disease; Bladder-disorders; Cigarette- ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=respiratory&f1=%2A&Startyear=&Adv=0&terms=1&EndYear=&Limit=10000&sort=&D1=10&PageNo=941&RecNo=9402&View=f&

Pancreatic cystic neoplasms (PCN) comprise a different group of histopathologic entities. True pancreatic cystic tumors fall ... True pancreatic cystic lesions account for only 10 to 15% of all pancreatic cystic lesions and less than 1% of pancreatic ... older patients are more likely to have premalignant or malignant cystic pancreatic neoplasms.. The majority of cystic neoplasms ... Background/Aim: Pancreatic cystic neoplasms are being increasingly identified with the widespread use of advanced imaging ...

https://saudijgastro.com/article.asp?issn=1319-3767

An analysis of all pancreatic resections performed for presumed PCN at the Verona Pancreas Institute, Italy, from 2011 through 2020 showed a high degree of discrepancy between the preoperative clinical diagnosis and the final postoperative pathology, with some lesions being misdiagnosed in nearly two-thirds of cases, reported Anna Burelli, MD, of the department of general and pancreatic surgery at the University of Verona. (medscape.com)
OBJECTIVE: To determine the factors predicting the subsequent development of pancreatic ductal adenocarcinoma in remnant pancreas (PDAC-RP) after partial pancreatectomy for PDAC. (elsevier.com)
Moreover, the density of pancreatic intraepithelial neoplasia lesions in the background pancreas of cases of PDAC concomitant with IPMN (1.86/cm) was higher than that of cases of PDAC without IPMN (0.91/cm) (P = 0.0007). (elsevier.com)
Cancer susceptibility of remnant pancreas after resection for PDAC concomitant with IPMN is probably due to an increased density of pancreatic intraepithelial neoplasia lesions. (elsevier.com)
Determine overall and disease-free survival of patients with resected stage I or II adenocarcinoma of the pancreas treated with adjuvant chemoradiotherapy in combination with GVAX pancreatic cancer vaccine. (clinicaltrials.gov)
Pancreatic parenchymal changes seen on endoscopic ultrasound are dynamic in the setting of fatty pancreas: A short-term follow-up study. (amedeo.com)
Appraising pancreatic fistula in pancreas transplantation: A comprehensive complication index based analysis of postoperative outcomes and predictors of graft survival. (amedeo.com)
BACKGROUND: Although invasive intraductal papillary mucinous neoplasm (IPMN) of the pancreas is thought to be more indolent than sporadic pancreatic adenocarcinoma (PAC), the natural history remains poorly defined. (va.gov)
This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Associati. (bvsalud.org)
OBJECTIVES: Clinical Practice Guidelines for Pancreatic Cancer based on Evidence-Based Medicine 2006 were first published by the Japan Pancreas Society, and they were revised to Clinical Practice Guidelines for Pancreatic Cancer 2009 in July 2009 and were further revised to Clinical Practice Guidelines f. (bvsalud.org)
Duodenal diverticula mimicking cystic neoplasm of the pancreas: CT and MR imaging findings in seven patients. (clinicalimaging.org)
Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas is. (biogps.org)
Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas is a precursor lesion of pancreatic cancer and progresses according to adenoma-carcinoma sequence. (biogps.org)
Cancerul pancreatic Cancer de pancreas borderline, Principalul element definitor pentru supravieţuire rămâne stadiul clinic şi cum majoritatea acestor cancere sunt depistate în stadii avansate supravieţuirea este pe măsură. (etigararunway.ro)
Disconnected duct syndrome is a pancreatic duct leak with a complete transection of the main pancreatic duct resulting in an isolated segment of the proximal (tail) portion of the pancreas. (micrornaarray.com)
Leaving the transmural stents in place creates an outlet for the pancreatic juice from the isolated tail segment of the pancreas. (micrornaarray.com)

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis [ 1 ]. (nature.com)
In this study, we analyzed the expression of several miRNAs in different types of pancreatic disease to determine if miRNA expression could aid in the diagnosis of pancreatic ductal adenocarcinoma (PDAC) and its precursor, pancreatic intraepithelial neoplasm (PanIN). (northwestern.edu)
Intraductal papillary mucinous neoplasm (IPMN), the most common pancreatic cystic neoplasm, is known to progress to invasive ductal adenocarcinoma. (elsevier.com)
There are a few studies concerning epidemiology of pancreatic ductal adenocarcinoma (PDAC) in the Polish population. (termedia.pl)
Invasive intraductal papillary mucinous neoplasm versus sporadic pancreatic adenocarcinoma: a stage-matched comparison of outcomes. (va.gov)
The incidence of pancreatic adenocarcinoma in the United States decreased by 19% in males and 5% in females from 2002 to 2005 compared with the incidence in the period between 1977 and 1981. (abdominalkey.com)

Pancreatic neuroendocrine neoplasms are rare tumors of which the genetic constitution is not fully understood. (eur.nl)
This thesis contains studies on the genetic make-up of pancreatic neuroendocrine tumors, the mechanisms of everolimus resistance and how to overcome this resistance. (eur.nl)
Pancreatic neuroendocrine neoplasms (pNENs) are rare tumors accounting for only 1-2% of all pancreatic tumors. (preprints.org)
OBJECTIVE\nThe pathogenesis of pancreatic neuroendocrine tumors (PNETs) is still unclear. (researchain.net)
Background/Aims: Pancreatic tumors in children and adolescents are uncommon. (elsevier.com)
Conclusion: In the setting of a high-volume surgical center, radical resection of pancreatic tumors in children and adolescents is associated with acceptable postoperative morbidity and favorable long-term outcome. (elsevier.com)
True pancreatic cystic lesions account for only 10 to 15% of all pancreatic cystic lesions and less than 1% of pancreatic tumors. (saudijgastro.com)
Introduction: Medical therapy of Pancreatic neuroendocrine tumors (P-NETs) may take advantage from mammalian target of rapamycin (mTOR) inhibitors. (endocrine-abstracts.org)
There are some data that insulin, IGFBP-3, folic acid and 25-OH-D may influence the development of these tumors.Aim: To study the influence of insulin, IGFBP-3, folic acid and 25-OH-D, CA 19-9, CA 72-4 in the development of tumors of the gastrointestinal tract, and the frequency of neoplasms detection.Materials and Methods. (endocrine-abstracts.org)
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of neoplasms arising from the diffuse neuroendocrine system. (cancernetwork.com)
We consulted our expert pathologist and he states "Since metastases have been reported in a few, and all the rest of the pancreatic endocrine tumors are now designated malignant, …we are safe considering them /3 until proven otherwise. (cancer.gov)
Purity Independent Subtyping of Tumors (PurIST), A Clinically Robust, Single-sample Classifier for Tumor Subtyping in Pancreatic Cancer. (unc.edu)
TNM staging of pancreatic tumors by EUS is feasible and accurate. (abdominalkey.com)
Of neoplasms in the appendix, carcinoid tumors remain the most common. (medscape.com)
In 1907, by which time carcinoid tumors were already histologically described and had been classified as carcinoma, Oberndorfer used the term "carcinoid" (carcinoma-like) as a modifier in order to distinguish their indolent behavior from other common gastrointestinal neoplasms. (medscape.com)

Pancreatic cancer / edited by Isidore Cohn and Paul R. Hastings. (who.int)
RESULTS: In univariate analysis, concomitant intraductal papillary mucinous neoplasm (IPMN) (P = 0.0005), cancer location (body/tail) (P = 0.0060), and lower T factor in UICC (P = 0.0039) were correlated with PDAC-RP development. (elsevier.com)
Pancreatic cancer usually begins in the cells that produce the juices. (medlineplus.gov)
Pancreatic cancer is hard to catch early. (medlineplus.gov)
Because it is often found late and it spreads quickly, pancreatic cancer can be hard to treat. (medlineplus.gov)
What Is Pancreatic Cancer? (medlineplus.gov)
Can Pancreatic Cancer Be Found Early? (medlineplus.gov)
RATIONALE: Vaccines made from gene-modified pancreatic cancer cells may make the body build an immune response to kill tumor cells. (clinicaltrials.gov)
Post surgery vaccination: Within 8-10 weeks after pancreaticoduodenectomy, patients receive GVAX pancreatic cancer vaccine intradermally (ID) on day 0. (clinicaltrials.gov)
Post chemoradiotherapy vaccination: Within 4-8 weeks after the completion of chemoradiotherapy, patients receive GVAX pancreatic cancer vaccine ID on days 0, 28, 56, and 196. (clinicaltrials.gov)
Evidence suggests that deregulated miRNA expression is associated with pancreatic cancer development. (northwestern.edu)
Approximately 10-20% of pancreatic cancer patients will have a mutation in their DNA, passed on in families, that contributes to the development of their pancreatic cancer. (mdpi.com)
The efficacy and safety of modified FOLFIRINOX for unresectable advanced pancreatic cancer in elderly versus young patients: A multicenter retrospective cohort study. (amedeo.com)
Focal pancreatic parenchyma atrophy is a harbinger of pancreatic cancer and a clue to the intraductal spreading subtype. (amedeo.com)
The prognostic role of fatigue, depression and anxiety on postoperative outcomes after pancreatectomy for pancreatic cancer. (amedeo.com)
Overall, no pancreatic cancer was observed in this collective during a 5-year follow-up. (bmj.com)
Purpose: To study the perioperative CT angiography (CTA) findings of modified Appleby procedure candidates for the surgical feasibility in patients with locally advanced distal pancreatic cancer (LAPC) and to assess CTA performance. (elsevier.com)
This guideline covers diagnosing and managing pancreatic cancer in adults aged 18 and over. (bvsalud.org)
According to the American Cancer Society, 43,140 new cases and 36,800 deaths from pancreatic cancer were expected in 2010. (abdominalkey.com)
The 5-year survival rate for pancreatic cancer is 5%, which is the lowest among gastrointestinal malignancies. (abdominalkey.com)
Recently, it was suggested that endoscopic ultrasound (EUS) evaluation of pancreatic cancer was an independent predictor of survival improvement in patients with locoregional pancreatic cancer. (abdominalkey.com)
In this article, we focus on the role of EUS in the evaluation and management of pancreatic cancer, including updates on novel approaches using EUS in the regional treatment of pancreatic cancer. (abdominalkey.com)
EUS has an integral role in the diagnosis of pancreatic cancer given its high sensitivity for detecting pancreatic neoplasms and the access it affords to perform fine needle aspiration (FNA) of the suspected lesions. (abdominalkey.com)
Magnetic resonance imaging (MRI) has similar accuracy to CT scanning in detecting pancreatic cancer and vascular invasion. (abdominalkey.com)
Soriano and colleageus compared the accuracy of CT, MRI, and EUS in assessing TNM staging of pancreatic cancer using surgical diagnosis as the gold standard. (abdominalkey.com)
Similar results were seen in another trial by Tian and co-workers, in which they found that helical CT had the highest accuracy in detecting vascular invasion of pancreatic cancer, and EUS had the highest accuracy of assessing lymph node metastases. (abdominalkey.com)
It is worth stressing that, although CT is more accurate in assessing T-staging of pancreatic cancer, EUS is still more sensitive and accurate in pancreatic lesions less than 3 cm in size. (abdominalkey.com)
The number of passes needed to obtain sufficient tissue for diagnosis is higher in pancreatic cancer than in other lesions, and varies from 4 to 7 passes among the studies. (abdominalkey.com)
There is a growing body of evidence that the 25-gauge needle may be superior to the 22-gauge needle in the diagnosis of pancreatic cancer. (abdominalkey.com)
STAT5b confers gemcitabine chemoresistance and promotes cell adherence and invasiveness in pancreatic cancer cells. (cusabio.com)
The researchers found that consuming two or more artificially-sweetened beverages daily was linked to a 5% increased risk for death from pancreatic cancer. (medscape.com)
Learn more about pancreatic cancer. (medscape.com)
According to estimates from the World Health Organization, 8.3 million people worldwide died from cancer and other neoplasms in 2008-about 14% of all deaths. (avalonecon.com)

Pancreatic resection specimens were selected, which included PDAC (n = 16), benign pancreatic parenchyma from corresponding carcinoma cases (n = 16), chronic pancreatitis (n = 4), normal pancreatic parenchyma (n = 5), and PanIN (n = 5). (northwestern.edu)
Carcinoma of the ampulla of Vater tends to manifest early due to biliary outflow obstruction, as opposed to pancreatic neoplasms that often are advanced at the time of diagnosis. (medscape.com)
Octreotide scintigraphy: This study can be considered for patients with metastatic Hürthle cell carcinoma because evidence suggests that some Hürthle cell neoplasms can express somatostatin receptors. (medscape.com)
We collected normal and neoplastic epithelial cells from frozen tissue sections (normal main pancreatic duct, IPMA, IPMC, and invasive carcinoma originating in IPMN) by laser microdissection, extracted total RNA from them, and analyzed their gene expression profiles using Affymetrix microarrays. (biogps.org)

Based on the MRI, a side-branch intraductal papillary mucinous neoplasm (SB-IPMN) was diagnosed and yearly surveillance was initiated. (eur.nl)
Is it necessary to follow patients after resection of a benign pancreatic intraductal papillary mucinous neoplasm? (elsevier.com)

Diagnostic errors are significant issues in care of patients with PCN, because clinicians must balance the need for prompt, definitive treatment when necessary with the need for avoiding the significant morbidity of pancreatic resection for patients with lesions that turn out to be nonmalignant. (medscape.com)
Three cases are presented and used to discuss the clinical implications of the renewed European Guideline on pancreatic cystic neoplasms in which relative and absolute indications for resection are proposed. (eur.nl)

Alkylating cytotoxic agents, such as streptozocin and temozolomide, play an important role in the treatment of pancreatic NETs, although estimated response rates vary widely and phase III data are lacking. (cancernetwork.com)
In summary, endoscopic treatment of pancreatic pseudocysts selleck chemicals appears to be effective, with a 94% initial success rate, 20% complication rate, and a 90% cyst resolution rate. (micrornaarray.com)

Receiver operating characteristic analysis to differentiate the high grade pancreatic neuroendocrine neoplasms (PNENs) from the low grade PNENs. (biomedcentral.com)

Intraductal papillary mucinous neoplasms (IPMNs) are premalignant pancreatic cysts of which a subset has the potential to. (nsw.gov.au)
The objectives of this analysis were to define the incidence and predictors of malignancy in pancreatic cysts. (saudijgastro.com)
Patients with true pancreatic cysts who were treated at our institution were included. (saudijgastro.com)
The most common pancreatic cysts were serous and mucinous cysts. (saudijgastro.com)
[4] The incidence of pancreatic cysts (PC) has been estimated to be between 1% and 2% in patients who had a computed tomography (CT)/magnetic resonance (MRI) imaging performed. (saudijgastro.com)
Objective To analyse the prevalence, incidence and clinical relevance of pancreatic cysts detected as incidental finding in a population-based longitudinal study. (bmj.com)
MRCP was analysed for pancreatic cysts with a diameter ≥2 mm. 676/1077 subjects received a 5-year follow-up (2014-2016). (bmj.com)
The prevalence and incidence of pancreatic cysts (weighted for study participation) were assessed in association to age, gender and suspected epidemiological risk factors. (bmj.com)
Results At baseline pancreatic cysts had a weighted prevalence of 49.1%, with an average number of 3.9 (95% CI 3.2 to 4.5) cysts per subject in the subgroup harbouring cysts. (bmj.com)
The 5-year follow-up revealed a weighted incidence of 12.9% newly detected pancreatic cysts. (bmj.com)
57.1% of the subjects initially harbouring pancreatic cysts showed an increase in number and/or maximum cyst size. (bmj.com)
Conclusion The prevalence of pancreatic cysts in the general population is unexpectedly high, and their number and size increase with age. (bmj.com)
Prospective follow-up data in a population-based setting suggest that most pancreatic cysts are harmless incidental findings. (bmj.com)
The true weighted incidence of pancreatic cysts above the size of 2 mm in the general population is 2.6% and dependent on age. (bmj.com)

Examples of neoplastic PCNs are intraductal papillary mucinous neoplasms (IPMNs) of the main pancreatic duct or side branch and mucinous cystadenomas. (medscape.com)
Per-oral pancreatoscopy-guided lithotripsy vs. extracorporeal shock wave lithotripsy for treating refractory main pancreatic duct stones in chronic pancreatitis: Protocol for an open-label multi-center randomized clinical trial. (amedeo.com)

After endoscopic ultrasound was performed, a serous cystic neoplasm was diagnosed without need for surveillance. (eur.nl)

A SOMATOSTATIN -secreting tumor derived from the pancreatic delta cells (SOMATOSTATIN-SECRETING CELLS). (bvsalud.org)

Morphological and clinical information alone still poorly frame actual targets for surgery, and hopefully the development of new reliable biomarkers will represent the next evolution in pancreatic cystic neoplasm management," she said in an oral abstract session at the annual Digestive Disease Week® (DDW). (medscape.com)
abstract = "Pancreatic cystic neoplasms are increasingly detected in the general population. (eur.nl)
abstract = "Background: Accurate grading of neuroendocrine neoplasms (NENs) is crucial for proper assessment of prognosis. (wustl.edu)

In the current study, Dr. Burelli and colleagues reviewed all pancreatic resections performed for PCNs at their center from 2011 through 2020. (medscape.com)

Inclusion criteria: All patients scheduled to receive elective pancreaticoduodenectomy (PD - Kausch-Whipple or LongmireTraverso) for all type of pancreatic disease (benign, malignant, or premalignant) will be enrolled. (who.int)

Consensus guidelines on the management of cystic pancreatic lesions have never been evaluated in a population-based setting. (bmj.com)
The prevalence of cystic pancreatic lesions in the general population on MRI corresponds to autopsy studies. (bmj.com)
The sensitivity of EUS for detecting pancreatic lesions ranges from 85% to 99% in most published series. (abdominalkey.com)
The sensitivity and accuracy of EUS are slightly higher than the sensitivity and accuracy of computed tomography (CT) in detecting small pancreatic lesions. (abdominalkey.com)
Pancreatic lesions usually appear on EUS as hypoechoic lesions with an irregular border. (abdominalkey.com)

For example, seven cases presumed to be serous cystic neoplasms (an almost always benign lesion) were found on final pathology to have a different, malignant histology. (medscape.com)
In the first case, a pancreatic cystic lesion was found on abdominal ultrasound in a 77-year old female patient. (eur.nl)
In a 57-year old male, an abdominal MRI was performed to further assess an incidentally found pancreatic cystic lesion. (eur.nl)

Cystic pancreatic endocrine neoplasm (CPEN)" is reportable. (cancer.gov)
Duodenal diverticulum mimicking a cystic pancreatic neoplasm. (clinicalimaging.org)

Interestingly, the incidence of pancreatic endocrine neoplasms increased over the same time periods by 106% in men and 125% in women. (abdominalkey.com)

Purpose: This study was designed to assess the potential role of the preoperative serum level of elastase 1 as a risk factor for recurrence in patients with resectable well-differentiated pancreatic neuroendocrine neoplasms (PanNETs). (fujita-hu.ac.jp)
Chronological improvement of pancreatectomy for resectable but advanced pancreatic neuroendocrine neoplasms. (amedeo.com)

Postoperative diabetes was diagnosed in 1 patient and 4 other patients developed pancreatic exocrine insufficiency. (elsevier.com)

However, small bowel neoplasms (benign and malignant) comprise only 4% of all GI tract neoplasms. (medscape.com)
Background/purpose: Laparoscopic liver surgery is attracting wider interest for the treatment of benign and malignant neoplasms. (elsevier.com)

CHICAGO - Preoperative clinical diagnoses of pancreatic cystic neoplasms (PCNs) are frequently found to be in error when patients go to surgery as recommended under international guidelines, data from a retrospective study show. (medscape.com)
Immunobiology and immunosurveillance in patients with intraductal papillary mucinous neoplasms (IPMN. (nsw.gov.au)
Eighty-one patients had true pancreatic cyst. (saudijgastro.com)
We sought to establish the degree of error in the grading of a cohort of curatively resected pancreatic NENs (PanNENs) and the theoretical impact of that in a larger cohort of Surveillance, Epidemiology, and End Results (SEER) patients. (wustl.edu)
Abdel-Rahman O , Ghosh S , Morrish D . Impact of baseline body mass index on the outcomes of patients with neuroendocrine neoplasms. (wjgnet.com)
Diabetes mellitus and the risk of progression or malignancy of pancreatic cystic neoplasms in patients undergoing surveillance: A systematic review and meta-analysis. (amedeo.com)
In 18/20 patients who received neoadjuvant chemoradiation, mean pancreatic mass size significantly reduced from 4.58 + 1.17 cm to 3.55 + 0.84 cm (p = 0.002). (elsevier.com)
Cytologic analysis of fine-needle aspiration (FNA) specimens can diagnose Hürthle cell neoplasm in most patients. (medscape.com)
This generally occurs as a result of severe acute pancreatitis with pancreatic necrosis and can be seen in up to 50% of these patients. (micrornaarray.com)

Preoperative imaging can clearly identify such variations and help to achieve a safer pancreatic head dissection with proper surgical planning. (scielo.br)
This report describes the utility of EUS to localize a solitary pancreatic insulinoma and provides a comparison of EUS and other preoperative localization techniques. (uthscsa.edu)

The common bile duct merges with the pancreatic duct of Wirsung to form a common channel that exits through the ampulla into the duodenum. (medscape.com)

Quan L , Liu Y , Cui W , Wang X , Zhang W , Wang Z , Guo C , Lu C , Hu F , Chen X . The associations between serum high-density lipoprotein cholesterol levels and malignant behavior in pancreatic neuroendocrine neoplasms. (wjgnet.com)

The aim of the present paper was to analyze short- and long-term outcomes after surgical treatment of primary pancreatic neoplasms in children and adolescents at a single high-volume center for pancreatic diseases. (elsevier.com)
Of all subjects undergoing MRCP, no participant died of pancreatic diseases within mortality follow-up. (bmj.com)

PDAC cells invade the stroma but can also invade back into and spread via the pancreatic ducts, which has been referred to as "cancerization of ducts" (COD). (nature.com)
Our data demonstrate that compared to the normal pancreatic parenchyma, miR-148a and miR-217 expression levels were down-regulated in PanIN, particularly in PanIN II-III and PDAC, whereas the level of miR-196 was significantly up-regulated in PDAC and its precursor, PanIN II-III. (northwestern.edu)

The tissue microarray included 12 grade 1 and 3 grade 2 PNETs and 14 grade 3 pancreatic neuroendocrine carcinomas (PECAs). (researchain.net)
3,4] Pancreatic NETs (pNETs) are usually hormonally silent but can secrete a variety of peptide hormones, including insulin, gastrin, glucagon, and vasoactive intestinal peptide (VIP). (cancernetwork.com)

La secreción hormonal depende del tipo de CÉLULAS DE LOS ISLOTES presentes en los tumores: GLUCAGÓN de las CÉLULAS PANCREÁTICAS ALFA, INSULINA de las CÉLULAS PANCREÁTICAS BETA y SOMATOSTATINA de las CÉLULAS D. La mayoría son malignos exceptuando a los tumres productores de insulina (INSULINOMA). (bvsalud.org)

Anatomy2

Organisms1

Diseases58

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Disciplines and Occupations1

Rational sequence of tests for pancreatic function. (1/9206)

Diphtheria toxin effects on human cells in tissue culture. (2/9206)

Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells. (3/9206)

Detection of liver metastases from pancreatic cancer using FDG PET. (4/9206)

Intensive weekly chemotherapy is not effective in advanced pancreatic cancer patients: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD). (5/9206)

Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results. (6/9206)

Gallstones, cholecystectomy and risk of cancers of the liver, biliary tract and pancreas. (7/9206)

Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms. (8/9206)

Pancreatic Neoplasms

Carcinoma, Acinar Cell

Creosote

Killifishes

Pancreatectomy

Pancreatic Cyst

Carcinoma, Pancreatic Ductal

Cystadenoma, Serous

Endoscopic Ultrasound-Guided Fine Needle Aspiration

Adenocarcinoma, Mucinous

Pancreas

Endosonography

Adenoma, Islet Cell

Pancreatic Ducts

Adenocarcinoma, Papillary

Carcinoma, Papillary

Adenocarcinoma

Pancreatitis

Tomography, X-Ray Computed

Neoplasms

Neoplasms, Cystic, Mucinous, and Serous

Skin Neoplasms

Neoplasms, Multiple Primary

Kidney Neoplasms

Neoplasms, Second Primary

Thyroid Neoplasms

Myeloproliferative Disorders

DNA, Neoplasm

Lung Neoplasms

Parotid Neoplasms

Cystadenoma

Neoplasms, Connective and Soft Tissue

Neoplasms, Plasma Cell

Appendiceal Neoplasms

Liver Neoplasms

Cystadenoma, Mucinous

Ovarian Neoplasms

Endocrine Gland Neoplasms

Gastrointestinal Neoplasms

Neoplasms, Experimental

Neoplasms, Vascular Tissue

Eye Neoplasms

Immunohistochemistry

Nose Neoplasms

Salivary Gland Neoplasms

Neoplasms, Radiation-Induced

Testicular Neoplasms

Neoplasms, Muscle Tissue

Neoplasms, Glandular and Epithelial

Cystadenocarcinoma, Mucinous

Adenoma

Soft Tissue Neoplasms

Hematologic Neoplasms

Neoplasm Proteins

Uterine Neoplasms

Intestinal Neoplasms

Neoplasms, Adnexal and Skin Appendage

Neoplasm Staging

Vascular Neoplasms

Sweat Gland Neoplasms

Lymphoma

Bone Neoplasms

Palatal Neoplasms

Neoplasms, Complex and Mixed

Antigens, Neoplasm

Mandibular Neoplasms

Cystadenocarcinoma

Bile Duct Neoplasms

Neoplasm Invasiveness

Thymus Neoplasms

Splenic Neoplasms

Rational sequence of tests for pancreatic function. (1/9206)

Diphtheria toxin effects on human cells in tissue culture. (2/9206)

Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells. (3/9206)

Detection of liver metastases from pancreatic cancer using FDG PET. (4/9206)

Intensive weekly chemotherapy is not effective in advanced pancreatic cancer patients: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD). (5/9206)

Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results. (6/9206)

Gallstones, cholecystectomy and risk of cancers of the liver, biliary tract and pancreas. (7/9206)

Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms. (8/9206)

Pancreatic Cancer Treatment Cost in Kolkata & Best Hospitals for Pancreatic Cancer Treatment in Kolkata