A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.
Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)
A nonapeptide that contains the ring of OXYTOCIN and the side chain of ARG-VASOPRESSIN with the latter determining the specific recognition of hormone receptors. Vasotocin is the non-mammalian vasopressin-like hormone or antidiuretic hormone regulating water and salt metabolism.
Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure.
Expulsion of milk from the mammary alveolar lumen, which is surrounded by a layer of milk-secreting EPITHELIAL CELLS and a network of myoepithelial cells. Contraction of the myoepithelial cells is regulated by neuroendocrine signals.
Hypothalamic nucleus overlying the beginning of the OPTIC TRACT.
Carrier proteins for OXYTOCIN and VASOPRESSIN. They are polypeptides of about 10-kDa, synthesized in the HYPOTHALAMUS. Neurophysin I is associated with oxytocin and neurophysin II is associated with vasopressin in their respective precursors and during transportation down the axons to the neurohypophysis (PITUITARY GLAND, POSTERIOR).
Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.
Contraction of the UTERINE MUSCLE.
The smooth muscle coat of the uterus, which forms the main mass of the organ.
A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
The repetitive uterine contraction during childbirth which is associated with the progressive dilation of the uterine cervix (CERVIX UTERI). Successful labor results in the expulsion of the FETUS and PLACENTA. Obstetric labor can be spontaneous or induced (LABOR, INDUCED).
A synthetic analog of vasopressin with ORNITHINE substitution at residue 8 of the cyclic nonapeptide. It is used as a local vasoconstrictor and hemostatic.
The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Nucleus in the anterior part of the HYPOTHALAMUS.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.
Artificially induced UTERINE CONTRACTION. Generally, LABOR, OBSTETRIC is induced with the intent to cause delivery of the fetus and termination of pregnancy.
The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.
The yellow body derived from the ruptured OVARIAN FOLLICLE after OVULATION. The process of corpus luteum formation, LUTEINIZATION, is regulated by LUTEINIZING HORMONE.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
Degradation of CORPUS LUTEUM. In the absence of pregnancy and diminishing trophic hormones, the corpus luteum undergoes luteolysis which is characterized by the involution and cessation of its endocrine function.
The behavior patterns associated with or characteristic of a mother.
The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.
In animals, the social relationship established between a male and female for reproduction. It may include raising of young.
Any behavior caused by or affecting another individual, usually of the same species.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete.
Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo.
Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than 500 ml or of the amount that adversely affects the maternal physiology, such as BLOOD PRESSURE and HEMATOCRIT. Postpartum hemorrhage is divided into two categories, immediate (within first 24 hours after birth) or delayed (after 24 hours postpartum).
(9 alpha,11 alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid (PGF(1 alpha)); (5Z,9 alpha,11,alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid (PGF(2 alpha)); (5Z,9 alpha,11 alpha,13E,15S,17Z)-9,11,15-trihydroxyprosta-5,13,17-trien-1-oic acid (PGF(3 alpha)). A family of prostaglandins that includes three of the six naturally occurring prostaglandins. All naturally occurring PGF have an alpha configuration at the 9-carbon position. They stimulate uterine and bronchial smooth muscle and are often used as oxytocics.
The final period of OBSTETRIC LABOR that is from the expulsion of the FETUS to the expulsion of the PLACENTA.
Failure of the UTERUS to contract with normal strength, duration, and intervals during childbirth (LABOR, OBSTETRIC). It is also called uterine atony.

Vasopressin stimulation of acetate incorporation into lipids in a dimethylbenz(a)anthracene-induced rat mammary tumor cell line. (1/1958)

In a preliminary report we described the effects of rat prolactin on the incorporation of [14C]acetate into lipids by a cell line from a dimethylbenz(a)anthracene-induced rat mammary tumor. The characteristics of the response to prolactin were very similar to those described for the normal rat mammary gland; namely, insulin was required for full expression of the response, maximal activity was not seen until 36 hr after the addition of the hormones, and growth hormone was able to elicit the same response. However, we were unable to detect binding of 125I-labeled prolactin to these cells, and furthermore, other more purified prolactin preparations were inactive. Upon further investigation we discovered that the activity resided in a low-molecular-weight fraction of the rat prolactin B-1 preparation and was probably either vasopressin or oxytocin or both. These data suggest the possibility that vasopressin may play a role in rodent mammary tumorigenesis.  (+info)

Central peptidergic neurons are hyperactive during collateral sprouting and inhibition of activity suppresses sprouting. (2/1958)

Little is known regarding the effect of chronic changes in neuronal activity on the extent of collateral sprouting by identified CNS neurons. We have investigated the relationship between activity and sprouting in oxytocin (OT) and vasopressin (VP) neurons of the hypothalamic magnocellular neurosecretory system (MNS). Uninjured MNS neurons undergo a robust collateral-sprouting response that restores the axon population of the neural lobe (NL) after a lesion of the contralateral MNS (). Simultaneously, lesioned rats develop chronic urinary hyperosmolality indicative of heightened neurosecretory activity. We therefore tested the hypothesis that sprouting MNS neurons are hyperactive by measuring changes in cell and nuclear diameters, OT and VP mRNA pools, and axonal cytochrome oxidase activity (COX). Each of these measures was significantly elevated during the period of most rapid axonal growth between 1 and 4 weeks after the lesion, confirming that both OT and VP neurons are hyperactive while undergoing collateral sprouting. In a second study the hypothesis that chronic inhibition of neuronal activity would interfere with the sprouting response was tested. Chronic hyponatremia (CH) was induced 3 d before the hypothalamic lesion and sustained for 4 weeks to suppress neurosecretory activity. CH abolished the lesion-induced increases in OT and VP mRNA pools and virtually eliminated measurable COX activity in MNS terminals. Counts of the total number of axon profiles in the NL revealed that CH also prevented axonal sprouting from occurring. These results are consistent with the hypothesis that increased neuronal activity is required for denervation-induced collateral sprouting to occur in the MNS.  (+info)

Production of prostaglandin f2alpha and its metabolite by endometrium and yolk sac placenta in late gestation in the tammar wallaby, Macropus Eugenii. (3/1958)

In this study, we investigated production of prostaglandin (PG) F2alpha and its metabolite, PGFM, by uterine tissues from tammar wallabies in late pregnancy. Endometrial explants were prepared from gravid and nongravid uteri of tammars between Day 18 of gestation (primitive streak) and Day 26.5 (term) and were incubated in Ham's F-10 medium supplemented with glutamine and antibiotics for 20 h. PGF2alpha and PGFM in the medium were assayed by specific, validated RIAs. Control tissues (leg muscle) did not produce detectable amounts of either PG. Both gravid and nongravid endometria secreted PGF2alpha, and production increased significantly in both gravid and nongravid uteri towards term. PGFM was produced in small amounts by both gravid and nongravid uteri, and the rate of production did not increase. Neither oxytocin nor dexamethasone stimulated PG production in vitro in any tissue at any stage. Thus, the surge in peripheral plasma PGFM levels seen at parturition may arise from increased uterine PG production, but further study is needed to define what triggers this release.  (+info)

Down-regulation of oxytocin-induced cyclooxygenase-2 and prostaglandin F synthase expression by interferon-tau in bovine endometrial cells. (4/1958)

Oxytocin (OT) is responsible for the episodic release of luteolytic prostaglandin (PG) F2alpha from the uterus in ruminants. The attenuation of OT-stimulated uterine PGF2alpha secretion by interferon-tau (IFN-tau) is essential for prevention of luteolysis during pregnancy in cows. To better understand the mechanisms involved, the effect of recombinant bovine IFN-tau (rbIFN-tau) on OT-induced PG production and cyclooxygenase-2 (COX-2) and PGF synthase (PGFS) expression in cultured endometrial epithelial cells was investigated. Cells were obtained from cows at Days 1-3 of the estrous cycle and cultured to confluence in RPMI medium supplemented with 5% steroid-free fetal calf serum. The cells were then incubated in the presence or absence of either 100 ng/ml OT or OT+100 ng/ml rbIFN-tau for 3, 6, 12, and 24 h. OT significantly increased PGF2alpha and PGE2 secretion at all time points (p < 0.01), while rbIFN-tau inhibited the OT-induced PG production and reduced OT receptor binding in a time-dependent manner. OT increased the steady-state level of COX-2 mRNA, measured by Northern blot, which was maximal at 3 h (9-fold increase) and then decreased with time (p < 0.01). OT also caused an increase in COX-2 protein, which peaked at 12 h (11-fold increase), as measured by Western blot. Addition of rbIFN-tau suppressed the induction of COX-2 mRNA (89%, p < 0.01) and COX-2 protein (50%, p < 0.01) by OT. OT also increased PGFS mRNA, and this stimulation was attenuated by rbIFN-tau (p < 0.01). To ensure that the decrease in COX-2 was not solely due to down-regulation of the OT receptor, cells were stimulated with a phorbol ester (phorbol 12-myristate 13-acetate; PMA) in the presence and absence of rbIFN-tau. The results showed that rbIFN-tau also decreased PMA-stimulated PG production and COX-2 protein. It can be concluded that rbIFN-tau inhibition of OT-stimulated PG production is due to down-regulation of OT receptor, COX-2, and PGFS.  (+info)

Oxytocin and vasopressin receptors in human and uterine myomas during menstrual cycle and early pregnancy. (5/1958)

The purpose of this study was to determine the specificity and concentration of oxytocin (OT) and arginine vasopressin (AVP) binding sites in non-pregnant (NP) human and rhesus monkey endometrium, myometrium and fibromyomas, and to determine the cellular localization of OT receptor (OTR). Besides [3H]AVP, [125I]LVA, a specific VP1 receptor subtype antagonist, was used to determine vasopressin receptor (VPR) concentrations. Samples were obtained from 42 pre-menopausal and three pregnant women (5, 13 and 35 weeks gestation), and several NP and pregnant monkeys. Specificity of binding was assessed in competition experiments with unlabelled agonists and antagonists of known pharmacological potency. Cellular localization of OTR was determined by immunohistochemistry. In NP human uterine tissues, [3H]AVP was bound with higher affinity and greater binding capacity than [3H]OT, whereas in pregnant women and in NP and pregnant rhesus monkeys, uterine OT binding capacity was greater. OT and AVP binding sites discriminated very poorly between OT and AVP; [125I]LVA binding sites were more selective than [3H]AVP. Their ligand specificity and binding kinetics indicated the presence of two distinct populations of binding sites for OT and AVP in primate uterus. Endometrium of NP women and monkeys had low OTR and VPR concentrations. Myometrial and endometrial OTR and VPR were down-regulated in midcycle and in early human pregnancy, they were up-regulated in the secretory phase and second half of pregnancy. Immunoreactive OTR in NP uterus was localized in patches of myometrial muscle cells and small numbers of endometrial epithelial cells.  (+info)

Desensitization of oxytocin receptors in human myometrium. (6/1958)

In the present study, we investigated the possible mechanisms by which oxytocin might regulate oxytocin receptor (OTR) density. Exposure of cultured myometrial cells to oxytocin for a prolonged period caused desensitization: the steady-state level of oxytocin binding was 210 x 10(3) binding sites/cell, but this was time-dependently reduced to 20.1 x 10(3) sites/cell by exposing the cells to oxytocin for up to 20 h. In contrast, Western blotting data showed that the total amount of OTR protein was not affected by oxytocin treatment for up to 24 h. Flow cytometry experiments demonstrated that OTRs were not internalized during this treatment. However, RNase protection assays and Northern analysis showed that in cultured myometrial cells OTR mRNA was reduced by oxytocin treatment to reach a new low steady-state concentration. Analysis of this mRNA in myometrial biopsies from 17 patients undergoing emergency Caesarean section showed how it decreased with advancing labour. Samples obtained after 12 h of labour contained approximately 50 times less OTR mRNA than samples obtained from patients in labour for less than 12 h. We speculate that this decrease in OTR mRNA represents in-vivo OTR desensitization.  (+info)

Uterine peristalsis during the follicular phase of the menstrual cycle: effects of oestrogen, antioestrogen and oxytocin. (7/1958)

Uterine peristalsis, directing sustained and rapid sperm transport from the external cervical os or the cervical crypts to the isthmic part of the tube ipsilateral to the dominant follicle, changes in direction and frequency during the menstrual cycle, with lowest activity during menstruation and highest activity at mid cycle. It was therefore suggested that uterine peristalsis is under the control of the dominant follicle with the additional involvement of oxytocin. To test this hypothesis, vaginal sonography of uterine peristalsis was performed in the early, mid and late proliferative phases, respectively, of cycles of women treated with oestradiol valerate and with human menopausal gonadotrophin following pituitary downregulation, with clomiphene citrate and with intravenous oxytocin, respectively. Administration of oestradiol valerate resulted in oestradiol serum concentrations comparable with the normal cycle with a simulation of the normal frequency of peristaltic contractions. Elevated oestradiol concentrations and bolus injections of oxytocin resulted in a significant increase in the frequency of peristaltic contractions in the early and mid follicular phases, respectively. Chlomiphene tended, though insignificantly so, to suppress the frequency of peristaltic waves in the presence of elevated oestradiol concentrations. In the late follicular phase of the cycle extremely elevated oestradiol concentrations as well as the injection of oxytocin resulted only in an insignificant further increase of peristaltic frequency. In the normal cycles, as well as during extremely elevated oestradiol concentrations and following oxytocin administration, the peristaltic contractions were always confined to the subendometrial layer of the muscular wall. The results and the review of literature indicate that uterine peristalsis during the follicular phase of the menstrual cycle is controlled by oestradiol released from the dominant follicle with the probable involvement of oxytocin, which is presumably stimulated together with its receptor within the endometrial-subendometrial unit and therefore acting in an autocrine/paracrine fashion. Since unphysiological stimulation with oestradiol and oxytocin did not significantly increase the frequency of uterine peristalsis in the late follicular phase of the cycle it is assumed that normal preovulatory frequency of uterine peristalsis is at a level which cannot be significantly surpassed due to phenomena of refractoriness of the system.  (+info)

Sperm transport in the human female genital tract and its modulation by oxytocin as assessed by hysterosalpingoscintigraphy, hysterotonography, electrohysterography and Doppler sonography. (8/1958)

The transport function of the uterus and oviducts and its modulation by oxytocin has been examined using hysterosalpingoscintigraphy, recording of intrauterine pressure, electrohysterography and Doppler sonography of the Fallopian tubes. After application to the posterior vaginal fornix, a rapid (within minutes) uptake of the labelled particles into the uterus was observed during the follicular and during the luteal phase of the cycle in all patients. Transport into the oviducts, however, could only be demonstrated during the follicular phase. Transport was directed predominantly into the tube ipsilateral to the ovary bearing the dominant follicle; the contralateral oviduct appeared to be functionally closed. The proportion of patients exhibiting ipsilateral transport did increase concomitant with the increase of the diameter of the dominant follicle. That ipsilateral transport has biological significance is suggested by the observation that the pregnancy rate following spontaneous intercourse or insemination was significantly higher in those women in whom ipsilateral transport could be demonstrated than in those who failed to exhibit lateralization. Oxytocin administration was followed by a dramatic increase in the amount of material transported to the ipsilateral tube, as demonstrated by radionuclide imaging and by Doppler sonography following instillation of ultrasound contrast medium. Continuous recording of intrauterine pressure before and after oxytocin administration did show an increase in basal tonus and amplitude of contractions and a reversal of the pressure gradient from a fundo-cervical to a cervico-fundal direction. These actions of oxytocin were accompanied by an increase in amplitude of potentials recorded by electrohysterography. These data support the view that uterus and Fallopian tubes represent a functional unit that is acting as a peristaltic pump and that the increasing activity of this pump during the follicular phase of the menstrual cycle is reflected by an increased transport into the oviduct ipsilateral to the ovary bearing the dominant follicle. In addition, they strongly suggest a critical role of oxytocin in this process. Failure of this mechanism appears to be a cause of subfertility or infertility, as indicated by the low pregnancy rate following intrauterine insemination or normal intercourse in the presence of patent Fallopian tubes. It may be regarded as a new nosological entity for which we propose the term tubal transport disorder (TTD). Since pregnancy rate of such patients is normal when treated with in-vitro fertilization (IVF), hysterosalpingoscintigraphy seems to be useful for the choice of treatment modalities in patients with patent Fallopian tubes suffering from infertility.  (+info)

Oxytocin and Personality. Evidence suggests that the neuropeptide oxytocin plays a role in social affiliation. This behavior may be related more to personality dimensions than specific psychiatric diagnoses. This study investigated the relationship between plasma oxytocin levels and personality dimensions using the Temperament and Character Inventory (TCI) in 60 outpatients with major depression. The strongest correlation was between plasma oxytocin levels and the temperament dimension of Reward Dependence (0.425 Pearson correlation). This suggested that 17% of the variance in plasma oxytocin levels was explained by the Reward Dependence scores. There was a significant positive correlation between plasma oxytocin levels and the Reward Dependence personality dimension.. Nicknamed the cuddle chemical because it renders a warm and fuzzy feeling inside, oxytocin, (a naturally produced hormone) has been shown via brain scan to lower activity in the amygdala - a region which is overactive in social ...
Oxytocin is both a hormone secreted by the pituitary gland and also a brain neurotransmitter. The actions of oxytocin are mediated by specific, high affinity oxytocin receptors. Oxytocin has a well-recognized role in breastfeeding, and uterine contraction.. In sexual medicine, oxytocin has a role in orgasm. Several studies have found increases in plasma oxytocin at orgasm. Plasma oxytocin levels are notably increased around the time of orgasm and are still higher than baseline when measured 5 minutes after self-arousal. It is possible that oxytocins effects on muscle contractibility may facilitate male sperm and female egg transport. Oxytocin levels in women before and after sexual stimulation suggests that oxytocin serves an important role in sexual arousal. One study showed that genital tract stimulation resulted in increased oxytocin immediately after orgasm. Another study reported increases of oxytocin during sexual arousal in response to nipple/areola, genital, and/or genital tract ...
Chronic neck and shoulder pain (CNSP) is a common musculoskeletal disorder in adults, which is linked to hypersensitivity to noxious stimuli. The hormone oxytocin has been implicated as a potential therapeutic for the management of chronic pain disorders, and has been suggested to have sex-specific effects on the salience of threatening stimuli. This study investigated the influence of intranasal oxytocin on the perception of noxious thermal stimuli. Participants were 24 individuals with CNSP lasting |12months (eight women), and 24 age- and sex-matched healthy, pain-free controls. In a randomised double-blind, placebo-controlled, cross-over study, participants attended two sessions, self-administering intranasal oxytocin (24 IU) in one session, and placebo in another. Participants rated intensity and unpleasantness of thermal heat stimuli at three body sites: the cervical spine, deltoid, and tibialis anterior, on 11-point numerical rating scales. Compared with placebo, intranasal oxytocin increased the
BACKGROUND A synthetic oxytocin analogue, barusiban, was shown to potently inhibit oxytocin-induced activity of myometrium from term pregnant women. The responsiveness to vasopressin was not influenced by the compound. OBJECTIVE To test the effect of barusiban and a reference compound, atosiban, on oxytocin-induced activity of myometrium from women at preterm pregnancy in comparison to myometrium from women at term. METHODS Fifteen preterm (30-36 gestational weeks) and 12 term pregnant women (38-41 weeks) who underwent cesarean delivery donated myometrial tissue for the study. Concentration-response curves following oxytocin administration to isolated myometrial strips were recorded in control experiments, in the presence of barusiban at concentrations of 2.5, 25, and 250 nM, and of atosiban at concentrations of 25, 250, and 750 nM. Effective concentration 50% (EC50) and pA2 values were calculated. RESULTS Both antagonists in higher concentrations increased the EC50 values to oxytocin. The median
[Besides its effect on the uterus and breasts, oxytocin also regulates affiliative behaviour. The so-called central oxytocin effect influences pair bonding, maternal care and attachment through the regulatory functions of oxytocin that acts as a neurotransmitter within the brain. The central oxytocin effect increases trust and social support, decreases fear and anxiety, and promotes wound healing. These effects form the basis of the stress-triggered, oxytocin-based calm and connection reaction. Some methods that are widely used in modern obstretric practice - such as the use of synthetic oxytocin for inducing or speeding up labour or epidural anaesthesia - hinder the psycho-emotive effects that are based on natural oxytocin. Epigenetic studies performed in animals indicate that the oxytocin effect experienced at birth can be transgenerational.]
Plasma oxytocin levels are significantly higher in oral contraceptive (OC) users than in to non-users, according to a study in Scientific Reports. The cross-sectional study of nearly 200 women also found that scores for satisfaction with life were higher among OC users.
China Oxy Acetate 2mg Hasten Parturition Peptides Oxytocin, Find details about China Oxytocin Price, Oxytocin Injection from Oxy Acetate 2mg Hasten Parturition Peptides Oxytocin - Changzhou General Import and Export Corporation
A recent study demonstrated that pregnant women with low oxytocin have a higher risk of postpartum depression. This should come as a surprise to no one. Studies have already demonstrated that low oxytocin release inhibits happy parenting. High oxytocin the opposite. Young non depressed fathers given oxytocin spray seem happier and are more likely to encourage their children to explore during playtime and are less likely to be hostile, compared to fathers given an oxytocin placebo. Mothers with higher oxytocin levels are less likely to be depressed adn more likely to coo to their babies in a playful voice, a speech scientists call motherese. High oxytocin mothers smile more at their babies and are more flexible to changes in its moods. The additional touching, looking into the eyes, lullabys releases even more oxytocin in both mother, father and child. Parents that look into each others eyes release more oxytocin. A test for parents with low oxytocin may one day help to identify mothers and ...
The aim of this thesis was to determine any association between plasma oxytocin and vasopressin concentrations and renal water and sodium excretion during normal pregnancy. In addition to investigate changes in concentrations of estradiol, progesterone, oxytocin, cortisol, and glucose in the blood before and in the nearest hours after delivery and if treatment with oxytocin affected these concentrations and the fluid balance during the different stages of labour.. Oxytocin, vasopressin, estradiol, progesterone, and cortisol were analysed in blood plasma or serum by radioimmunoassay or ELISA: serum glucose, and osmolality, and sodium in plasma and urine were analysed by standard laboratory techniques.. Fifty-seven women were studied during pregnancy and fifty-one during parturition and post partum. The low plasma vasopressin and increasing plasma oxytocin concentrations with unchanged water and sodium excretion indicate that oxytocin assists vasopressin in concentrating urine during ...
Oxytocin increases the salience of both positive and negative social contexts and it is thought that these diverse actions on behavior are mediated in part through circuit-specific action. This hypothesis is based primarily on manipulations of oxytocin receptor function, leaving open the question of whether different populations of oxytocin neurons mediate different effects on behavior. Here we inhibited oxytocin synthesis in a stress-sensitive population of oxytocin neurons specifically within the medioventral bed nucleus of the stria terminalis (BNSTmv). Oxytocin knockdown prevented social stress-induced increases in social vigilance and decreases in social approach. Viral tracing of BNSTmv oxytocin neurons revealed fibers in regions controlling defensive behaviors, including lateral hypothalamus, anterior hypothalamus, and anteromedial BNST (BNSTam). Oxytocin infusion into BNSTam in stress naïve mice increased social vigilance and reduced social approach. These results show that a population ...
The aim of this study was to use functional neuroimaging to investigate whether oxytocin modulates the neural response to visual food cues in brain regions involved in the control of food intake. Twenty-four normal weight volunteers received intranasal oxytocin (24 IU) or placebo in a double-blind, randomized crossover study. Measurements were made forty-five minutes after dosing. On two occasions, functional MRI (fMRI) scans were performed in the fasted state; the blood oxygen level-dependent (BOLD) response to images of high-calorie foods versus low-calorie foods was measured. Given its critical role in eating behaviour, the primary region of interest was the hypothalamus. Secondary analyses examined the parabrachial nuclei and other brain regions involved in food intake and food reward. Intranasal oxytocin administration suppressed hypothalamic activation to images of high-calorie compared to low-calorie food (P = 0.0125). There was also a trend towards suppression of activation in the ...
Oxytocin is a hormone produced by the brain that appears to have important roles in social cognition and emotion in humans. In a pilot study, the effects of a single dose of oxytocin on measures of emotion recognition and behaviour in patients with Frontotemporal Dementia were investigated. The results from the pilot study suggested that oxytocin may be associated with a modest improvement in neuropsychiatric behaviours seen in patients with Frontotemporal Dementia. To further examine the safety and tolerability of oxytocin in this disorder, the present study will examine the safety and tolerability of three different doses of intranasal oxytocin administered to patients with Frontotemporal Dementia twice daily for 1 week ...
The oxytocin-inactivating activity (OIA) of liver, kidney, uterus, pancreas, spleen and duodenum homogenates of hens was studied. The first-order constant of oxytocin inactivation was higher in the liver and pancreas than in the uterus and kidney or in the duodenum and spleen. Using synthetic analogues of oxytocin (deamino-oxytocin, deamino-carba1-oxytocin and carba1-oxytocin the mechanism of enzymic inactivation of oxytocin by hen tissue was investigated.. Enzymic hydrolysis by the CH2-terminal cleavage was most marked in duodenum (about 86% OIA) and kidney (54·8% OIA). Reduction of the disulphide bridge was most marked in the uterus (about 80% OIA) and pancreas (about 73% OIA). Splitting by non-specific aminopeptidases after reduction of the disulphide bridge occurred mainly in the liver (72% OIA) and in the spleen (44% OIA). ...
PART 2 The endogenous oxytocin system changes and matures over time as part of normal development. This paper postulates that individual factors and early external influences (i.e. parenting, stress and illness) affect the developing endogenous oxytocin system and its connectivity with other systems affecting oxytocin levels and alter responsiveness of the oxytocin system. When…
Abstract: Background: Oxytocin, a commonly used drug to prevent uterine atony after caesarean section, should be administered as dilute rapid infusion rather than as a bolus. This study was conducted to calculate ED90 of oxytocin infusion during caesarean delivery in parturients at high risk of postpartum haemorrhage (PPH). Materials and Methods: One hundred and twenty parturients having one or more risk factors for PPH received a blinded infusion of oxytocin following emergency caesarean delivery. The initial dose of oxytocin infusion was started as 0.4 IU min−1. The dose of oxytocin infusion for the next parturient was based on the response of preceding patient in increments or decrements of 0.1 IU min−1 as per a biased-coin design up-down sequential method (UDM). Measurements of non-invasive blood pressure and heart rate were taken at 2 min intervals from the time of oxytocin infusion. Intraoperative blood loss was noted. Side effects such as tachycardia, hypotension, nausea, vomiting, ...
Background: Oxytocin infusion is used for induction or augmentation of labor to prevent prolonged labor. A cheap and nonaggressive alternative which is effectively used for contraction stress test is nipple stimulation. However research regarding its efficacy and safety is still limited. This study aims to compare the effectiveness of nipple stimulation and oxytocin infusion on the duration of phases of labor.Methods: This randomized clinical trial included 132 low-risk pregnant women admitted to Asali hospital in 2006 -2007. Those having poor contractions in active phase of labor were randomly assigned into two groups of nipple stimulation and oxytocin infusion. Women in the nipple stimulation group had their nipples messaged by hands moving in circle and using lubricant gel. The oxytocin infusion was started at 0.25 mIU/min for the oxytocin infusion group. Data collection was carried out through observation, examination and interviews. Data were analyzed using statistical tests, repeated measure test,
Anxious patients treated with even the best currently available anti-anxiety drugs continue to experience significant symptoms.. A variety of basic science, animal studies, and human studies support the idea that the neuropeptide oxytocin may be effective against anxiety in humans. For example, plasma oxytocin levels may function as an index of central serotonin (5-HT) function in human subjects, and serotonin is well-known to be involved in clinical anxiety disorders. Since oxytocin is released directly from limbic-hypothalamic cells, this response presumably represents a direct central assessment of 5-HT response in limbic-hypothalamus (Lee 2003). In animal models, Ring 2006 examined the effects of oxytocin on both behavioral and autonomic parameters of the anxiety response in male mice using three pharmacologically validated preclinical models of anxiety: the four-plate test (FPT), elevated zero maze (EZM), and stress-induced hyperthermia (SIH). The results from this study provide specific ...
Oxytocin is a neurohormone that has been correlated with lactation, uterine-contractions, postpartum behavior, pro-social behavior, trust, empathy, and decreased anxiety. In addition, oxytocin is believed to underscore the tend-and-befriend response to stress. In this study, adrenocorticotropic hormone (ACTH), cortisol and oxytocin levels were measured in response to a social stressor in human participants. Oxytocin was initially seen to increase with ACTH and cortisol in response to a social stressor. As levels of oxytocin increase, levels of ACTH and cortisol were shown to decrease or plateau. I conclude that oxytocin is released in response to a perceived stressor and display inhibitory effects over ACTH and cortisol.
A highly sensitive and specific radioimmunoassay (RIA) for oxytocin was developed and used to measure oxytocin concentrations during both suckling and parturition in individual rats. In urethane-anaesthetized rats, the suckling stimuli, provided by ten pups, induced intermittent increases in intramammary pressure of about 10 mmHg. This was associated with a significant (P , 0·01) increase in serum oxytocin levels from 19·5 ± 4·5 (s.e.m., n = 9) to 49·1 ± 7·4 pmol/l (n = 9) in the samples taken within 30 s from the time of the peak in the pressure. These rises in serum oxytocin returned rapidly to the basal levels as expected from the short half-life (1·46 min) of oxytocin in general circulation.. On day 22 or 23 of gestation, serum oxytocin levels remained stable until 0-0·5 h before the first fetus was expelled. They then increased significantly (P , 0·01) from 27·6± 4·6 pmol/l (n = 19) in samples taken 0-0·5 h before to 45·1 ± 5·6 pmol/l in samples taken after the expulsion of ...
Maybe Im jumping too quickly to put two and two together but juxtaposing the description of the effect of Smiths Nambian root with the actions of oxytocin, I cant but wonder if there is some connection. There are numerous examples of other plants which contain hormones. Could this root contain oxytocin or could something in it stimulate oxytocin release in people? Food for thought, eh?. Here is concise but partial summary of oxytocins actions in the brain from Wikipedia:. 1. Sexual arousal. Oxytocin injected into the cerebrospinal fluid causes spontaneous erections in rats, reflecting actions in the hypothalamus and spinal cord. 2. Bonding. In the Prairie Vole, oxytocin released into the brain of the female during sexual activity is important for forming a monogamous pair bond with her sexual partner. Vasopressin appears to have a similar effect in males. In people, plasma concentrations of oxytocin have been reported to be higher amongst people who claim to be falling in love. Oxytocin has ...
Hypothalamic oxytocin (OT) is released into the brain by cyclic ADP-ribose (cADPR) with or without depolarizing stimulation. Previously, we showed that the intracellular free calcium concentration ([Ca2+]i) that seems to trigger OT release can be elevated by -NAD+, cADPR, and ADP in mouse oxytocinergic neurons. As these -NAD+ metabolites activate warm-sensitive TRPM2 cation channels, when the incubation temperature is increased, the [Ca2+]i in hypothalamic neurons is elevated. However, it has not been determined whether OT release is facilitated by heat in vitro or hyperthermia in vivo in combination with cADPR. Furthermore, it has not been examined whether CD38 and TRPM2 exert their functions on OT release during stress or stress-induced hyperthermia in relation to the anxiolytic roles and social behaviors of OT under stress conditions. Here, we report that OT release from the isolated hypothalami of male mice in culture was enhanced by extracellular application of cADPR or increasing the
AMHERST, Mass. - The hormone oxytocin appears to increase social behaviors in newborn rhesus monkeys, say researchers at the National Institutes of Health, the University of Parma, Italy, and the University of Massachusetts Amherst. Findings suggest that oxytocin is a promising candidate for new treatments for developmental disorders affecting social skills and bonding.. Oxytocin, a hormone produced by the pituitary gland, is involved in labor, birth and breast milk production. Studies have also shown that oxytocin plays a role in parental bonding, mating and social interactions. Because of this, many researchers have suggested that oxytocin might be useful in treating conditions affecting social behavior such as autism spectrum disorders.. Earlier research in adults has shown that oxytocin increases certain social behaviors, says behavioral endocrinologist Jerrold Meyer of UMass Amherst, but the current study is the first to show that it may have the same effect in primate infants, including ...
The effect of oxytocin on phosphoinositide metabolism as well as on membrane protein phosphorylation in myometrial tissue was studied. Oxytocin enhanced the 32P incorporation into phospholipids in myometrial tissue. The effect of oxytocin on phosphoinositide metabolism was also detected in plasma membrane of 20 days pregnant rats. Phosphorylated membrane lipids have been analysed and phosphatidylinositol 4, 5-bisphosphate proved to be the main reaction product. Oxytocin enhanced the 32P incorporation into phospholipids measured in the first 30 sec then the labeling decreased more rapidly then in case of the control. The effect of oxytocin proved to be concentration dependent. The protein phosphorylation was also influenced by oxytocin. However the amount of alkylphosphate formed depended on the presence or absence of Ca2+, Ca2+-calmodulin and cyclic AMP, oxytocin influenced the protein phosphorylation in the presence of Ca2+-calmodulin only.
Oxytocin Injection may be used as a uterine contractor to precipitate and accelerate normal parturition, the postpartum evacuation of uterine debris, and to facilitate udder milk-letdown.
Buy Oxytocin Injection, Vial, USP, 10 Units/mL, 1mL online at Emergency Medical Products (EMP) - your source for emergency medical supplies.
Learn about Oxytocin Injection (Canada) for animal usage including: active ingredients, directions for use, precautions, and storage information.
Oxytocin is critical for lactation and maternal care, but oxytocin and the related nonapeptide vasopressin are important for caregiving behaviors in fathers and alloparents as well. This experiment tested the effects of vasopressin and oxytocin on food sharing in marmoset families. We treated caregivers (parents, siblings) with intranasal vasopressin, oxytocin, or saline, and then paired them with the youngest marmoset in the family. Caregivers were given preferred food, and then observed for food sharing and aggressive behavior with young marmosets. Oxytocin reduced food sharing from male alloparents to youngest siblings, and fathers that received vasopressin refused to share food with their youngest offspring more often than when treated with oxytocin. Vasopressin increased aggressive vocalizations directed toward potential food recipients in all classes of caregivers. These results indicate that vasopressin and oxytocin do not always enhance prosocial behavior: modulation of food sharing depends on
Elephant specific information, if available, is in blue.. Chemistry - A nonapeptide hypothalamic hormone stored in the posterior pituitary (in mammals), oxytocin occurs as a white powder that is soluble in water. The commercially available preparations are highly purified and have virtually no antidiuretic or vasopressor activity when administered at usual doses. Oxytocin potency is standardized according to its vasopressor activity in chickens and is expressed in USP Posterior Pituitary Units. One unit is equivalent of approximately 2.0 - 2.2 micrograms of pure hormone.. Commercial preparations of oxytocin injection have their pH adjusted with acetic acid to 2.5-4.5 and multi-dose vials generally contain chlorbutanol 0.5% as a preservative.. Storage/Stability/Compatibility - Oxytocin injection should be stored at temperatures of less than 25°C, but should not be frozen. Some manufacturers recommend storing the product under refrigeration (2-8°C), but some products have been demonstrated to be ...
Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys: © 2015 the Am
The main goal of the study is to look at the effects of intranasal oxytocin on the brain in Autism Spectrum Disorder (ASD). Oxytocin is a hormone that exists
Question: What is oxytocin?. Paul: Oxytocin is a mammalian neurochemical that your brain makes and is released during almost any positive social interaction. It motivates us to engage with other people. When your brain makes oxytocin, you have an increased sense of empathy for about ½ hour and reduced stress. During that time, you are more motivated to connect to people around you . The release of oxytocin also activates a much larger network in the brain, called the HOME Network: Human Oxytocin Mediated Empathy system. Oxytocin facilitates the mid-brain to release a chemical called dopamine that is essentially the reward signal. It makes us feel good. Nature has set up a system that rewards us we connect to others, as we relax and feel good.. The HOME Network directly improves the systems of depression, anxiety, and loneliness. It can also directly impact and potentially slow tumor growth by reducing the production of the stress hormone cortisol. Question: What has your oxytocin research ...
© 2014, PLOS ONE. Recent work has shown that oxytocin is involved in more than lactation and uterine contraction. The paraventricular nucleus of the hypothalamus (PVN) contains neuroendocrine neurons that control the release of hormones, including vasopressin and oxytocin. Other populations of PVN neurons do not release hormones, but rather project to and release neurotransmitters onto other neurons in the CNS involved in fluid retention, thermoregulation, sexual behavior and responses to stress. Activation of oxytocin receptors can be cardioprotective and reduces the adverse cardiovascular consequences of anxiety and stress, yet how oxytocin can affect heart rate and cardiac function is unknown. While anatomical work has shown the presence of peptides, including oxytocin, in the projections from the PVN to parasympathetic nuclei, electrophysiological studies to date have only demonstrated release of glutamate and activation of fast ligand gated receptors in these pathways. In this study, using rats,
The neuropeptide oxytocin has been implicated in social behavior and is being evaluated as a possible treatment for autism spectrum disorders and schizophrenia, but the neural mechanisms through which oxytocin modulates social behavior remain largely unknown. One possibility is that social interaction recruits the brains reward circuits and that oxytocin plays a role in this process, which ultimately reinforces social behavior. In a recent study, Dolen et al. elucidate key circuits and mechanisms through which oxytocin can modulate social behavior via actions on the nucleus accumbems, a key component of the brains reward circuitry.. Dolen et al. studied social conditioned place preference (social CPP), in which mice prefer to spend time in a chamber that was previously associated with social interaction instead of in a chamber previously associated with social isolation. This task measures the rewarding effects of social interactions. Dolen et al. found that ablating presynaptic oxytocin ...
Oxytocin production increases the more you get the stress out of your life. A very interesting aspect of this hormone is, the more you increase it, the more you make!
The first bit of evidence that points to oxytocin as natures love glue comes from researchers who measured the hormone in couples. Psychology professor Ruth Feldman at Bar-Ilan University in Israel, spent years studying oxytocins role in the mother-child bond and recently decided to dive into the uncharted waters of romantic bonds by comparing oxytocin levels in new lovers and singles. The increase in oxytocin during the period of falling in love was the highest that we ever found, she says of a study she and her colleagues published in Psychoneuroendocrinology. New lovers had double the amount Feldman usually sees in pregnant women ...
OBJECTIVE: To investigate the involvement of serotonin (5-hydroxytryptamine - 5-HT) receptors in mediation of stress-induced arginine vasopressin (AVP) and oxytocin (OT) secretion in male rats.. DESIGN: Experiments on laboratory rats with control groups.. METHODS: Different stress paradigms were applied after pretreatment with intracerebroventricular infusion of saline or different 5-HT antagonists.. RESULTS: Restraint stress (5 min), hypotensive hemorrhage or dehydration for 24 h increased AVP secretion fivefold and OT secretion threefold. Swim stress for 3 min had no effect on AVP secretion, but increased OT secretion threefold. Ether vapor or hypoglycemia had no effect on AVP or OT secretion. The restraint stress-induced AVP response was inhibited by pretreatment with the 5-HT(2A+2C) antagonists ketanserin (KET) and LY-53857 (LY) and the 5-HT(3+4) antagonist ICS-205930 (ICS), whereas the 5-HT(1A) antagonist WAY-100635 (WAY) had no effect. The OT response to restraint stress was inhibited by ...
China 2mg Per Vial Oxytocin Musle Gain Peptide Oxytocin 50-56-6, Find details about China Oxytocin, 50-56-6 from 2mg Per Vial Oxytocin Musle Gain Peptide Oxytocin 50-56-6 - Shanghai Shucan Industrial Co., Ltd.
This study used population-based data to examine the relationship between peripartum synthetic oxytocin administration and the development of depressive and anxiety disorders within the first year postpartum.
Human beings make decisions based on implicit and explicit processes. The implicit processes are regulated by hormones; however, the same hormone could affect multiple behaviors. In this study, I will modify oxytocin levels by manipulating feelings of trustworthiness and observe if the changes in oxytocin levels affect a distinct construct controlled by this hormone: evaluative processes of romantic stimuli. I will utilize a neuroeconomic game to manipulate endogenous oxytocin levels and observe whether this manipulation changes peoples attitudes towards romantic pictures and their overall desire for a romantic connection.
Oxytocin, a peptide produced in the brain, may bring hearts together or it can help induce aggression. That conclusion arises from unique research by scientist in which mice living in semi-natural conditions had their oxytocin producing brain cells manipulated in a highly precise manner. The findings could shed new light on efforts to use oxytocin to treat a variety of psychiatric conditions, from social anxiety and autism to schizophrenia.
Background: Research in mammals has demonstrated the involvement of oxytocin (OT) in social bond formation; yet, its role in human bonding remains unclear. Plasma OT has been used as a proxy for central activity and studies indicate its association with human affiliative behaviors. Molecular genetic studies also reveal a role for OT neuropathways in shaping the social brain. However, the links between peripheral OT, genetic markers, and their combined contribution to human parenting are unknown. Methods: Participants included 352 individuals: 272 mothers and fathers and their 4- to 6-month-old-infants and 80 nonparents. Plasma OT was assayed from adults who were genotyped for oxytocin receptor (OXTR) and CD38 risk alleles associated with social dysfunctions. CD38 is an ectoenzyme that mediates the release of brain OT. Parent-infant interactions were microcoded for parental touch and gaze synchrony and participants reported on parental care in childhood. Results: OXTR (rs2254298 and rs1042778) ...
Oxytocin analogues (pitocin, Syntocinon®) are used to induce labour and support labour in case of non-progression of the parturition. It has largely replaced ergotamine as the principal agent to increase uterine tone in acute postpartum haemorrhage. An oxytocin nose spray may be a useful adjunct to stimulate breastfeeding. Inhibition of oxytocin action is the mode of action of the new tocolytic agent atosiban (Tractocile®), which is registered in many countries to suppress premature labour between 24 and 33 weeks of gestation. It has fewer side-effects than drugs previously used for this purpose (ritodrine, salbutamol and terbutaline). A 2005 study by Fehr et al suggested that nasally administered oxytocin worked to generate trust in humans. They demonstrated that in a risky investment game, experimental subjects given the hormone displayed what the researchers deemed the highest level of trust twice as often as the control group who were given placebos. The same experiment with the subjects ...
Development of myometrium in young female rats was stimulated by administration of diethylstilboestrol. Plasma membrane and sarcoplasmic reticulum from rat myometrium were separated by a new and rapid method using a Percoll gradient. Calcium uptake was inhibited in plasma membrane vesicles isolated from oxytocin-treated myometrium, while no consistent effect of oxytocin was found on the Ca2+ uptake in the sarcoplasmic reticulum. Oxytocin regulated the plasma membrane Ca2+ pump by decreasing its apparent affinity for Ca2+ without affecting its maximal velocity. The K1/2 for Ca2+ in the absence of calmodulin was 0.41 +/- 0.04 microM in normal membranes; this was increased to 0.93 +/- 0.12 microM in oxytocin-treated membranes. Calmodulin decreased the K1/2 for Ca2+ to 0.27 +/- 0.027 microM and oxytocin also increased this, to 0.46 +/- 0.061 microM. The effect of oxytocin on the plasma membrane Ca2+ pump was highly dependent on the hormonal status of the animals. When the diethylstilboestrol was ...
Oxytocin is a hormone primarily known for increasing bonding, social behaviour and closeness between parents, children and couples. Increased oxytocin levels have been found, for example, in partners in functional relationships. In women, it is also produced during the childbirth process and during breastfeeding to increase the mothers bond with the baby.
Answer: Real. Researchers in Poland recently looked into the issue of retained placenta in draft mares, desiring to answer the question of why treatment of a retained placenta with repeated injections of oxytocin so often fails. They put forth the hypothesis that it may be the expression of oxytocin receptors that differs in mares that retain fetal membranes due to secondary uterine atony (lack of physiologic tone, muscle weakness). The objective of this study was to determine whether the expression of oxytocin receptors in equine placental tissue differs in these draft mares that normally pass their fetal membranes vs. those mares that retain them. Placental biopsies were taken from 8 draft mares during foaling. 4 mares passed their placenta shortly after foaling (control group) and 4 mares retained their placenta due to secondary uterine atony. The number of oxytocin receptors was estimated and the presence and location of these receptors determined. Results showed that the oxytocin receptor ...
Trust pervades human societies. Trust is indispensable in friendship, love, families and organizations, and plays a key role in economic exchange and politics. In the absence of trust among trading partners, market transactions break down. In the absence of trust in a countrys institutions and leaders, political legitimacy breaks down. Much recent evidence indicates that trust contributes to economic, political and social success. Little is known, however, about the biological basis of trust among humans. Here we show that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions. We also show that the effect of oxytocin on trust is not due to a general increase in the readiness to bear risks. On the contrary, oxytocin specifically affects an individuals willingness to accept social risks arising through
Ive linked before to this article that speculates that women with low oxytocin levels may experience depression associated with weaning from breastfeeding. Specifically, previous studies have suggested that women who have naturally low levels of oxytocin will suffer from depression. That made sense to me. When you breastfeed, your body is supposed to release oxytocin,…
BACKGROUND: The neuropeptide oxytocin is increasing the focus of many studies investigating human and animal social behaviours and diseases. However, interpretation and comparison of results is made difficult by a lack of consistent methodological approaches towards analysing this hormone. NEW METHOD: This study determined the sample collection and analysis protocols that cause the least amounts of protocol dependant variation in plasma oxytocin concentrations detected by ELISA. The effect of vacutainer type, sample extraction prior to analysis and capture and restraint protocol were investigated while validating an assay protocol for two novel species, grey seals (Halichoerus grypus) and harbour seals (Phoca vitulina). RESULTS: Where samples are extracted prior to analysis, vacutainer type (EDTA mean: 8.25±0.56pg/ml, heparin mean: 8.25±0.62pg/ml, p=0.82), time taken to obtain a sample and restraint protocol did not affect the concentration of oxytocin detected. However, concentrations of ...
Oxytocin, a hormone that promotes emotional bonding, also benefits people having trouble dealing with stress. A new study suggests that giving oxytocin for a week shortly following a traumatic experience reduces the risk that the recipient will develop post-traumatic stress disorder (PTSD).. In the study by researcher Mirjam van Zuiden and colleagues, people who visited an emergency room following some kind of trauma were randomized to receive either a placebo nasal spray or intranasal oxytocin twice daily for 7.5 days beginning within 12 days after the trauma. The dosage was 40 IU twice daily.. For those participants with severe PTSD symptoms at baseline, repeated oxytocin administration prevented worsening PTSD. The research was presented at the 2016 meeting of the Society of Biological Psychiatry.. ...
View our 3 Oxytocin Receptor Antagonists products for your research including Oxytocin Receptor Antagonists Small Molecules and Oxytocin Receptor Antagonists Peptides.
All patients receiving intravenous oxytocin must be under continuous observation by trained personnel with a thorough knowledge of the drug and qualified to identify complications. A physician qualified to manage any complications should be immediately available.. When properly administered, oxytocin should stimulate uterine contractions similar to those seen in normal labor. Overstimulation of the uterus by improper administration can be hazardous to both mother and fetus. Even with proper administration and adequate supervision, hypertonic contractions can occur in patients whose uteri are hypersensitive to oxytocin.. Except in unusual circumstances, oxytocin should not be administered in the following conditions: prematurity, borderline cephalopelvic disproportion, previous major surgery on the cervix or uterus including Caesarean section, overdistention of the uterus, grand multiparity or invasive cervical carcinoma. Because of the variability of the combinations of factors which may be ...
Background: Oxytocin is widely used for the prevention of postpartum haemorrhage. In the setting of Caesarean section (CS), the dosage and mode of administrating oxytocin differs according to different guidelines. Inappropriate oxytocin doses have been identified as contributory to some cases of maternal deaths. The main aim of this study was to audit the current standard of clinical practice with regard to the use of oxytocin during CS at a referral hospital in Botswana. Methods: A clinical audit of pregnant women having CS and given oxytocin at the time of the operation was conducted over a period of three months. Data included indications for CS, oxytocin dose regimen, prescribing clinicians designation, type of anaesthesia for the CS and estimated blood loss. Results: A total of 139 case records were included. The commonest dose was 20 IU infusion (31.7%). The potentially dangerous regimen of 10 IU intravenous bolus of oxytocin was used in 12.9% of CS. Further doses were utilized in 57 ...
DopaFibra - actionvation of dopamine nervous fire for oxytocin production, penile/clitoral/G-spot erection and sexual orgasm Bioelectricity is The Foundation of Life and Love. AND What are the solutions. Sexual KungFu for womens Multiple Orgasms, Tao for Prolonging sexual intercourse, and Recovering from impotence and frigidity by vacuum cupping massage & herbs.
Oxytocin is released in response to a fatty meal. Blockage of the oxytocin receptor led to slower gastric emptying whereas stimulation resulted in less satiety in healthy volunteers. Patients with diabetes mellitus and gastroparesis lack oxytocin elevation, and dyspepsia is partly caused by reduced fundus accommodation causing early satiety and related symptoms. The aim of this study was thus to examine the effect of oxytocin on gastric emptying, satiety and volume intake in patients with gastrointestinal pathology. Gastric emptying scintigraphy was performed twice in 12 patients with diabetic gastroparesis, once with oxytocin and once with saline as intravenous infusions. The patients scored their sensation of satiety using a visual analogue scale (VAS). The gastric emptying in patients with gastroparesis was prolonged during oxytocin infusion (p = 0.034) without affecting satiety. A slow satiety drinking test was performed in 14 patients with functional dyspepsia. The patients scored their satiety
BioAssay record AID 513723 submitted by ChEMBL: Displacement of [3H]-oxytocin from human oxytocin receptor expressed in HEK293-EBNA cells.
Autism spectrum disorder is associated with deficits in three main behavioral areas: social behaviors, repetitive behaviors, and language abnormalities. Accumulating evidence suggests a potential role for oxytocin signaling in the etiology of autism. Oxytocin signaling is integral to complex social behaviors such as fear, social recognition, and monogamous pair bonding initiation (Wang and Aragona 2004; Kirsch, Esslinger et al. 2005; Choleris, Little et al. 2007). Furthermore, evidence of a causal relationship between altered oxytocin levels and repetitive behaviors exists both humans and animals (Drago, Pederson et al. 1986; Hollander, Novotny et al. 2003). However, limited research exists to document a role for oxytocin and oxytocin related peptides in communication related behavior either in humans or animal models. Oxytocin immunoreactive neurons have been found in brain areas associated with the vocal behaviors of both the mustached bat and the plainfin midshipman fish and increased plasma ...
Oxytocin is a hormone produced in an area of the brain known as the hypothalamus, whose release activates a variety of brain regions resulting in many different functions, including birth (labor), breast feeding (lactation), maternal behavior, parental care, social bonding, affiliation (such as couples being together), and well-being. In recent studies in humans, oxytocin has been shown to be associated with increases in prosocial behaviors such as trust, altruism, generosity, cooperation and empathy. These various functions suggest that oxytocin may promote health by reducing stress and increasing calm/relaxed states, resulting in improved quality of life and well-being.. Given oxytocins stress-reducing and calming properties, and its capacity to increase well-being, its action may be relevant to those fighting cancer. We conducted a study to look at the effects of two mind-body therapies on changes in salivary oxytocin levels in a cancer survivor population with self-reported sleep ...
How is Dysphoric Milk Ejection Reflex abbreviated? D-MER stands for Dysphoric Milk Ejection Reflex. D-MER is defined as Dysphoric Milk Ejection Reflex somewhat frequently.
The purpose of this study is to compare the change in suck and swallow competency from baseline to day 5 with intranasal oxytocin spray vs placebo in
OBJECTIVE: To study the effects of early versus delayed oxytocin augmentation on the obstetrical and neonatal outcome in nulliparous women with spontaneous but prolonged labour. DESIGN: Randomised controlled study. SETTING: Two delivery units in Sweden. POPULATION: Healthy nulliparous women with normal pregnancies, spontaneous onset of active labour, a cervical dilatation of 4-9 cm and no progress in cervical dilatation for 2 hours and for an additional hour if amniotomy was performed due to slow progress. METHODS: Women (n = 630) were randomly allocated either to labour augmentation by oxytocin infusion (early oxytocin group) or to postponement of oxytocin augmentation for another 3 hours (expectant group). MAIN OUTCOME MEASURE: Mode of delivery (spontaneous vaginal or instrumental vaginal delivery or caesarean section) and time from randomisation to delivery. RESULTS: The caesarean section rate was 29 of 314 (9%) in the early oxytocin group and 34 of 316 (11%) in the expectant group (OR 0.8, 95% CI 0
Background: Autism spectrum disorder (ASD) is multifactorial and is likely the result of complex interactions between multiple environmental and genetic factors. Recently, it has been suggested that each symptom cluster of the disorder, such as poor social communication, may be mediated by different genetic influences. Genes in the oxytocin pathway, which mediates social behaviours in humans, have been studied with single nucleotide polymorphisms (SNPs) in the oxytocin receptor gene (OXTR) being implicated in ASD. This thesis examines the presence of different oxytocin receptor genotypes, and their associations with ASD and resulting social communication deficits. Methods: The relationship between four OXTR variants and ASD was evaluated in 607 ASD simplex (SPX) families. Cases were compared to their unaffected siblings using a conditional logistic approach. Odds ratios and associated 95 percent confidence intervals were obtained. A second sample of 235 individuals with a diagnosis of ASD was ...
TY - JOUR. T1 - Comparison of particle-associated progesterone and oxytocin in the ovine corpus luteum. AU - Rice, G. E.. AU - Jenkin, G.. AU - Thorburn, G. D.. PY - 1986/1/1. Y1 - 1986/1/1. N2 - The subcellular distribution of progesterone and oxytocin within the ovine corpus luteum was investigated using differential and density gradient centrifugation. Progesterone and oxytocin were associated with particles which sedimented to a density of 1.049-1.054 g/ml and 1.054-1.061 g/ml respectively. Particle-associated progesterone did not, however, display physical or biochemical characteristics consistent with its storage within secretory granules. When particle-associated progesterone was incubated in HEPES buffer at 37°C, 70% of the total progesterone was recovered in the incubation medium. The remaining stable particle-associated progesterone was not affected by treatments which stimulated oxytocin release and which have been shown to cause the release of peptides and biogenic amines from ...
MDMA (±3,4-methylenedioxymethamphetamine, ecstasy) is used recreationally, reportedly because it increases feelings of empathy, sociability, and interpersonal closeness. One line of evidence suggests that MDMA produces these effects by releasing oxytocin, a peptide involved in social bonding. In the current study, we investigated the acute effects of MDMA and oxytocin on social and emotional processing in healthy human volunteers. MDMA users (N=65) participated in a 4-session, within-between-subjects study in which they received oral MDMA (0.75, 1.5 mg/kg), intranasal oxytocin (20 or 40 IU), or placebo under double-blind conditions. The primary outcomes included measures of emotion recognition and sociability (desire to be with others). Cardiovascular and subjective effects were also assessed. As expected, MDMA dose-dependently increased heart rate and blood pressure and feelings of euphoria (eg, High and Like Drug). On measures of social function, MDMA impaired recognition of angry and ...
Institute of Reproductive and Developmental Biology, Hammersmith Hospital Campus (S.H.K., A.D.J.F., P.R.B., V.T.) and Chelsea and Westminster Hospital (V.T.), Imperial College London, London, United Kingdom; and ObsEva SA, Geneva, Switzerland (O.P., A.C., J.-P.G ...
The 1980s heralded the discovery and identification of extra-pituitary sources of the neurohypophysial hormone oxytocin in non-neural tissues of several animal species. The presence, location and biosynthesis of significant amounts of oxytocin in the ovarian corpus luteum was followed by the immunocytochemical demonstration of an oxytocin-like peptide in the testicular interstitial cells. Leydig cells, which comprise up to 80% of the testicular intertubular cell population, are known to synthesize testosterone in situ. Indirect evidence indicated that an oxytocin-like peptide was also present in Leydig cells.. The question arose whether this peptide was synthesized de novo by Leydig cells or was taken up and stored by the cells following biosynthesis at some other intra- and/or extra-gonadal source(s). Since luteinizing hormone (LH) and ascorbate are known to augment the production of oxytocin in ovarian granulosa cells, varying concentrations of these two stimulants were used to monitor the ...
4): 270-77) The autistic group appeared to have significantly lower blood oxytocin levels than the normal group.... ... Artificial induction of labour creates situations that undoubtedly interfere with the development and the reorganization of the oxytocin system in such a critical period. This fact alone is a reason for further epidemiological studies focusing on labour induction as a possible risk factor. It would be useful to know also how autistic children release oxytocin. Oxytocin is more effective when released rhythmically, in a succession of fast pulsations. Today it is possible to measure the rhythmicity the pulsatility of oxytocin release. In other words, the time has come to study autism as an impaired capacity to love.. Midwifery Todays Editor Jan Triton notes: Oxytocin is a hormone released by the posterior pituitary gland. Its mechanical effects, particularly its stimulating effects on uterine contractions during labour, have been known for a long time. Recently we learned ...
Recent research has suggested that oxytocin receptor gene (OXTR) variants may account for individual differences in social behavior, the effects of stress and parenting styles. Little is known, however, on a putative role of the gene in heritable temperamental traits. We addressed effects of two common OXTR variants, rs237900 and rs237902, on personality dimensions in 99 healthy subjects using the Temperament and Character Inventory. When sex was controlled for and an OXTR genotype*sex interaction term was included in the regression model, 11% of the variance in Harm Avoidance could be explained (uncorrected p ≤ 0.01). Female carriers of the minor alleles scored highest, and a novel A217T mutation emerged in the most harm avoidant male participant. Findings lend support to a modulatory effect of common OXTR variants on Harm Avoidance in healthy caucasian women and invite resequencing of the gene in anxiety phenotypes to identify more explanatory functional variation.
I will be writing more about each speakers presentation when time permits. I was very interested in Dr. Nanit Gordons presentation about Oxytocins Impact on Social Cognitive Brain Function in Youth with ASD which seemed to follow directly from a presentation I heard earlier in a preconference session about parental behaviors and childrens capacity to become members of the social group, understand complex social signals and develop social collaboration. I reference that session in paragraph 2). Dr. Gordon presented data including fMRI images showing the effect of Oxytocin on areas of the brain important to the aforementioned social capacities. Oxytocin was one of the response items to certain types of interaction, particularly parental interaction. My concern and my questions concerned whether if parental interaction increases a hormonal response, oxytocin, which improves capacity for at risk children to develop social capacity does that imply that our current research is indicating a return ...
ENCODES a protein that exhibits neuropeptide hormone activity (ortholog); oxytocin receptor binding (ortholog); INVOLVED IN drinking behavior (ortholog); eating behavior (ortholog); female pregnancy (ortholog); PARTICIPATES IN oxytocin signaling pathway; ASSOCIATED WITH anxiety disorder (ortholog); autistic disorder (ortholog); Burns (ortholog); FOUND IN cytoplasm (ortholog); extracellular region (ortholog); extracellular space (ortholog)
TY - JOUR. T1 - Transcriptional regulation of the oxytocin receptor gene. AU - Bale, Tracy L.. AU - Dorsa, Daniel M.. PY - 1998/12/29. Y1 - 1998/12/29. UR - http://www.scopus.com/inward/record.url?scp=0031647807&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0031647807&partnerID=8YFLogxK. M3 - Review article. C2 - 10026818. AN - SCOPUS:0031647807. VL - 449. SP - 307. EP - 315. JO - Advances in Experimental Medicine and Biology. JF - Advances in Experimental Medicine and Biology. SN - 0065-2598. ER - ...
The Role of Oxytocin as a Potential Biomarker for Psychosis Dr. Woolley has been studying the underpinnings of social deficits in schizophrenia and is currently examining oxytocins potential as a treatment for the social dysfunction observed in patients with schizophrenia. Individuals with schizophrenia often demonstrate significant social cognitive deficits that can impair the formation and maintenance of healthy relationships, and negatively impact social interactions and community participation. However, there are currently no pharmacological treatments available to target these deficits. In healthy individuals, the natural hormone oxytocin has been shown to enhance social abilities such as understanding emotions and trusting others. Thus, a primary focus of our research has been to examine whether supplementary oxytocin administration can improve social cognition in individuals with schizophrenia, which may ultimately lead to stronger relationships, improved social and occupational ...
This review describes the recent literature surveyed regarding the synthesis of 2,4-diaryl-3-azabicyclo[3.3.1]nonanone (3-ABNs) and their biological activities in the last six years (2008-2014). These heterocyclic compounds are obtained from the Mannich reaction of ketones, aldehydes and ammonium acetate in polar aprotic solvents.
The Dublin High Court has heard that the misuse of syntocinon resulted in birth injuries to a young girl who now suffers from dyskinetic cerebral palsy.. Grace Orchard (8) from Carrigaline in County Cork was born at St Finbarr´s Maternity Hospital on 23rd February 2006. Prior to her delivery, her mother had been administered the drug syntocinon to speed up her contractions.. However, syntocinon also has the effect of exacerbating foetal distress and rather than conduct a Caesarean section on her mother, Grace was delivered by forceps after four previous attempts to bring her into the world - including one using a vacuum cup - had failed.. Grace had to be resuscitated after she was born, and was in a poor condition due to the trauma she had suffered in the womb. She was subsequently diagnosed with dyskinetic cerebral palsy which - according to her solicitor - was attributable to appalling poor handling by hospital staff during her delivery.. Through her mother - Deidre O´Callaghan - Grace ...
Trust plays an important role in the formation and maintenance of human social relationships. But trusting others is associated with a cost, given the prevalence of cheaters and deceivers in human society. Recent research has shown that the peptide hormone oxytocin increases trust in humans. However, oxytocin also makes individuals susceptible to betrayal, because under influence of oxytocin, subjects perseverate in giving trust to others they know are untrustworthy. Testosterone, a steroid hormone associated with competition and dominance, is often viewed as an inhibitor of sociality, and may have antagonistic properties with oxytocin. The following experiment tests this possibility in a placebo-controlled, within-subjects design involving the administration of testosterone to 24 female subjects. We show that compared with the placebo, testosterone significantly decreases interpersonal trust, and, as further analyses established, this effect is determined by those who give trust easily. We ...
Order Oxytocin Receptor ELISA Kits for many Reactivities. Chicken, Cow, Human and more. Compare Oxytocin Receptor ELISA Kits and find the right product on antibodies-online.com.
This proposal research focuses on the biology underlying prosociality, which centers on emotions and behaviors that benefit others, in mother-baby-grandmother triads. One specific aim will center on how moral elevation, an emotional state generated through witnessing great acts of compassion, is related to caregiving behaviors and variations in the oxytocin system, a hormone important for an array of prosocial behaviors, including social bonding. In addition, the mothers and grandmothers will answer questionnaires to capture other aspects of their experiences. Our main investigation is to show that the emotional state of moral elevation is linked to epigenetic and genetic profiles of the oxytocin receptor gene, autonomic physiology, psychological profiles, behavioral displays, and oxytocin release. Altogether, this multimethod approach will explore the relationship between static (genetic) and dynamic (hormone, epigenetic) oxytocinergic profiles in the context of socioemotional processing influenced by
So, this study is suggesting that oxytocin, the love and bonding neurotransmitter, may play a bigger role in other activities than previously thought. This makes a lot of sense intuitively - of course, if you are in a state of liking, bonding, attraction, inhibition-reduction, and novelty-seeking, you are more likely to be creative, or be able to quickly adopt new ideas or new ways of thinking.. http://scan.oxfordjournals.org/content/early/2013/07/16/scan.nst094.abstract Oxytonergic circuitry sustains and enables creative cognition in humans. Using double-blind placebo-controlled between-subjects designs, Studies 3-6 (N = 191) finally showed that intranasal oxytocin (vs matching placebo) reduced analytical reasoning, and increased holistic processing, divergent thinking and creative performance. We conclude that the oxytonergic circuitry sustains and enables the day-to-day creativity humans need for survival and prosperity and discuss implications. . ...
Syntocinon (Oxytocin) Nasal Spray is used for the inducement of contractions. In addition it is used for the stimulation of labour in woman who have too week contractions.
INJECTABLE SOLUTION. Composition:. Each ml solution contains:. 10 I.U. synthetic oxytocin.. Spectrum of activity:. Oxytocin (pituitary posterior lobe extract) is a hormone, influencing sensibilized uterine musculature in the late stage of pregnancy, during and a few days after parturition.. It is used for speeding expulsion of the foetus or foetuses, and after parturition it promotes the expulsion of the placenta and the involution of the uterus. Owing to its effect on myoepithelial cells around the alveoli of the udder, it stimulates and increases the secretion of milk.. Indications:. Weak pains in the course of delivery, puerperal atonia of the uterus, retention of the placenta, post partum haemorrhage, prolapse of uterus, post partum agalactia, in mares, cows, sows, ewes, goats, bitches, cats.. Contra-indications:. Incomplete cervical dilatation, disposition of the foetus; too big foetus.. Side-effects:. Short vasodilatation, decreased blood pressure and/or hyper stimulation of the uterus if ...
Before you shop for the cuddle hormone oxytocin to relieve stress and enhance your social life, read this: a new study from the University of California, Davis, suggests that sometimes, blocking the action of oxytocin in the brain may be a better option. The results are published online in the journal Biological Psychiatry.
Women have a very important hormone named oxytocin that is found to play a huge role in building social interaction and relationships in mammals, especially humans. This hormone is also found to help connect us to others. The trust, closeness, pleasant touch, eye contact, and empathy are all triggered in an individual with the help of the hormone. The oxytocin levels in the mother are found to have an impact on the childs behavior and also help mothers build a stronger bond with their baby. According to Tobias Grossmann from the Max Planck Institute and Jessica Connelly and Kathleen Krol from the University of Virginia, the development of oxytocin system in a child is found to rely on the mothers behavior.. During childhood, an individual has his/her systems maturing either physiologically or behavior-wise as a step to adulthood. Oxytocin plays an important role in early social, perceptual, & cognitive functions and even complex social behaviors also depend on the hormone. The recent study has ...
Happy Thanksgiving Week! This is your brain on Oxytocin after a passionate kiss! Im going to give you a Thanksgiving assignment this year with a twist of Oxytocin!
Read Regionally Specific Effects of Oxytocin on Reinstatement of Cocaine Seeking in Male and Female Rats, International Journal of Neuropsychopharmacology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Consequence of Exogenous Administration of Oxytocin on Reproductive and Productive Parameters during Postpartum Involution Period in Newly Calved Nili-Ravi Buffaloes
How childhood trauma can impair our capacity to love others with particular reference to oxytocin and how to naturally increase oxytocin levels.
Oxytocin Sprays: oxytocin squirt contain oxytocin which helps you to build trust and others. Following using it, you can be a lot more believe in worthy person for other people. This will help you connect with other people effortlessly. These sprays can be applied to various areas of the body like neck wrists cloths and so on. These days many different varieties of oxytocin sprays are available in market. Most of them have incredible effects and have helped many people to achieve results goals. When these types of oxytocins are usually smelled simply by other people their oxytocin degree increase and immediately creates an automatics developing ...
Introduction: Co-administration of phenylephrine prevents oxytocin-induced hypotension during caesarean section under spinal anaesthesia (SA), but higher doses cause reflex bradycardia. This study compares the effects of co-administration of two different doses of phenylephrine on oxytocin-induced hypotension during caesarean section under SA. Methods: In this prospective, double-blind study, 90 parturients belonging to the American Society of Anesthesiologists physical status 1 or 2, undergoing caesarean section under SA were randomised into Group A: oxytocin 3U and phenylephrine 50 μg, Group B: oxytocin 3U and phenylephrine 75 μg, Group C: oxytocin 3U and normal saline, administered intravenously over 5 min after baby extraction ...
NEUROHYPOPHYSIAL FUNCTION DURING ACUTE OSMOTIC STIMULATION IN RATS : ROLE OF VASOPRESSIN IN REGULATION OF BLOOD PRESSURE AND OXYTOCIN RELEASE A Thesis Submitted to the Faculty in partial fulfillment of the requirements for the degree of Doctor of Philosophy by Wing-Tai Savio Cheng DARTMOUTH COLLEGE Hanover, New Hampshire August 1986 ...
S]tudies are finding that oxytocin can increase the amount of money people will donate to a charity. One study in particular lent credence to the time honored method charities use to pull money from magazine readers: Feature a woebegone child in your advertisement. In the study, researchers had subjects watch a tearjerker film of a father talking about his sons brain tumor. They sampled subjects blood before and after the film. Following the film the blood was awash in oxytocin, and their donations to charity rose 47 percent, compared to those of subjects who saw a film of the same father talking about a trip to the zoo. The tearjerker technique was more effective on women than men. Experiments wherein people sniff oxytocin to bolster the chemical in their brain show that the chemical may work in two ways. It may operate first by dampening our natural fear of one another. Oxytocin is very active in the amygdala, which monitors the world for danger. Extra oxytocin fights fear. Then, with that ...
Scientists recently found the gene responsible for constructing social memory. According to the July issue of Nature Genetics, researchers at Emory University School of Medicine in Atlanta, Georgia, discovered that the oxytocin gene enables an individual to recognize someone previously encountered.. If the oxytocin gene is missing or defective, then severe deficits in social memory occur. Without this fundamental ability, even your own mother would remain a stranger, study author James T. Winslow told the press. With the help of some transgenic or knockout male mice who lacked the oxytocin gene, researchers were able to expose the link between genetics and social memory. In order to test the social behaviors of mice, Winslow and his team closely observed the way mice use their sense of smell. A normal male mouse will use its sense of smell in order to get to know a female mouse until she becomes familiar. If a male and female are reintroduced 30 or 60 minutes after separation, the male ...
Background: Caesarean section is one of the most commonly performed major operations in women throughout the world. Rates are escalating, with studies from the United States of America, the United Kingdom, China and the Republic of Ireland reporting rates between 20% and 25%. Operative morbidity includes haemorrhage, anaemia, blood transfusion and in severe cases, maternal death. The value of routine oxytocics in the third stage of vaginal birth has been well established and it has been assumed that these benefits apply to caesarean delivery as well. A slow bolus dose of oxytocin is recommended following delivery of the baby at caesarean section. Some clinicians use an additional infusion of oxytocin for a further period following the procedure. Intravenous oxytocin has a very short half-life (4?10 minutes) therefore the potential advantage of an oxytocin infusion is that it maintains uterine contractility throughout the surgical procedure and immediate postpartum period, when most... ...
... has a molecular mass of 1007 Da, and one international unit (IU) of oxytocin is the equivalent of 1.68 μg of pure ... Oxytocin is believed to have a significant role in social learning. There are indicators that oxytocin may help to decrease ... Secretion of oxytocin from the neurosecretory nerve endings is regulated by the electrical activity of the oxytocin cells in ... In male rats, oxytocin may induce erections. A burst of oxytocin is released during ejaculation in several species, including ...
... orally bioavailable oxytocin antagonists. Peptide Carbetocin Demoxytocin Lipo-oxytocin-1 Merotocin Oxytocin Non-peptide TC OT ... The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of ... Wikimedia Commons has media related to Oxytocin receptors. Oxytocin+receptor at the US National Library of Medicine Medical ... Several selective ligands for the oxytocin receptor have recently been developed, but close similarity between the oxytocin and ...
One IU of oxytocin is the equivalent of about 2 μg or mcg of pure peptide. Injection: Clinical doses of oxytocin are given by ... Intranasal oxytocin has a central duration of at least 2.25 hours and as long as 4 hours. Oral: Oxytocin is destroyed in the ... Oxytocin's milk ejection property was described by Ott and Scott in 1910 and by Schafer and Mackenzie in 1911. Oxytocin was the ... Synthetic oxytocin, sold under the brand name Pitocin among others, is a medication made from the peptide oxytocin. As a ...
"Oxytocin" as an EDM song: The Ringer Source labling "Oxytocin" as an electronica song: ABC News Sources labling "Oxytocin" as ... "Oxytocin" as the 86th best song of 2021 according to the website's readers. "Oxytocin" was released as the fifth track on ... "Oxytocin" has been called the 20th best song by Billie Eilish by Far Out Magazine's Tyler Golsen, stating it is the "perfect ... "Oxytocin" received many comparitions to other artists' works. For The Line of Best Fit, Matthew Kent saw that the song is "club ...
... (LOT-1) is a synthetic peptide and derivative of oxytocin that acts as an agonist of the oxytocin receptor. The ... After adjusting for molecular weight (LOT-1 is ~1.5x the weight of oxytocin), oxytocin and LOT-1 are equipotent. In addition, ... "Lipo-oxytocin-1, a Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-Lasting Effects on Anxiety-Related ... It has yet to be determined whether LOT-1 possesses improved blood-brain-barrier permeability relative to oxytocin. Carbetocin ...
... Oxytocin (OT) has potential to be a treatment for Postpartum Depression (PPD)[1]. ... This method is often the preferred method[4]. Oxytocin (OT) is a neuropeptide that can be administered in this manner. IN ... A review of 38 randomized and controlled trials suggests that short-term use of intranasal oxytocin appears to have few side- ... Short-term use of intranasal oxytocin (OT) appears to be equally safe in vulnerable individuals as well as those deemed healthy ...
In 2019, a large review of the effects of oxytocin found that the oxytocin level in fathers that engage in SSC is increased as ... Oxytocin is further released during labour when the fetus stimulates the cervix and vagina, and it is believed that it plays a ... Oxytocin is the most common method used to increase the rate of vaginal delivery. The World Health Organization recommends its ... The act of nursing a child also causes a release of oxytocin to help the baby get milk more easily from the nipple. Station ...
"Oxytocin, Carbetocin". IOCB Prague. Retrieved 2022-08-05. Prague, IOCB. "Guaiazulene". IOCB Prague. Retrieved 2022-08-05. ... the development of first method for industrial production of human neurohypophysial hormone oxytocin by Josef Rudinger, ...
... oxytocin; VSP: vasopressin; NP: Neuropeptides; KOR, MOR, DOR: kappa-, mu- and delta-opioid receptors correspondingly. The FET ...
Oxytocin and coitus. Sexual and Relationship Therapy (1988);3:29-36 Carter CS. Oxytocin and sexual behavior. Neuroscience & ... Oxytocin has been suggested as critical to the thoughts and behaviors required to maintain close relationships.[verification ... Prolactin and oxytocin are responsible for inducing milk production in women. Follicle-stimulating hormone (FSH) is responsible ... Sexual intimacy and orgasms increase levels of oxytocin, which helps people bond and build trust. A long-term study of 3,500 ...
Oxytocin and coitus. Sexual and Relationship Therapy (1988);3:29-36 Carter, CS. (1992). "Oxytocin and sexual behavior". ... Lee HJ, Macbeth AH, Pagani JH, Young WS (June 2009). "Oxytocin: the great facilitator of life". Prog. Neurobiol. 88 (2): 127-51 ... increases levels of the hormone oxytocin, also known as "the love hormone", which helps people bond and build trust. Sexual ...
The hormones oxytocin and vasopressin are implicated in regulating both male and female sexual motivation. Oxytocin is released ... Based on the pleasure model of sexual motivation, the increased sexual pleasure that occurs following oxytocin release may ... Emotional closeness can be an especially strong predictor of sexual motivation in females and insufficient oxytocin release may ... Keverne E. B.; Curley J. P. (2004). "Vasopressin, oxytocin and social behaviour". Neurobiology. 14 (6): 777-783. doi:10.1016/j. ...
"Oxytocin intranasal - Vyera Pharmaceuticals". AdisInsight. Retrieved 24 September 2017. Mullin, Emily (February 27, 2015). " ... Syntocinon, short for 'synthetic oxytocin', was first introduced by the Swiss pharmaceutical company Sandoz in 1956. The ... "Retrophin Signs U.S. License Agreement for Syntocinon™ Nasal Spray (Oxytocin)". Business Wire. December 12, 2013. Retrieved 19 ... This product, also called TUR-001, is Turing Pharmaceuticals' oxytocin nasal solution. ...
"Oxytocin and social norms reduce xenophobia". University of Bonn. 12 August 2017. Retrieved 5 May 2019. "Raus aus der ... "Oxytocin and social norms reduce xenophobia". University of Bonn. 12 August 2017. Retrieved 5 January 2019. Michelle Castillo ( ... Scheele, D. (2012). "Oxytocin Modulates Social Distance between Males and Females". The Journal of Neuroscience. 32 (46): 16074 ... The same year, Hurlemann published research showing that oxytocin combined with a prominent social norm, could lead to ...
... is a non-peptide partial agonist of the oxytocin and vasopressin V2 receptors (Ki = 147 nM and >1000 nM, respectively ... "Non-peptide oxytocin agonists". Bioorganic & Medicinal Chemistry Letters. 14 (17): 4585-4589. doi:10.1016/j.bmcl.2004.04.107. ... Oxytocin receptor agonists, Vasopressin receptor agonists, Vasopressin receptor antagonists, Thioamides, All stub articles, ...
I.D. Neumann, R.K. Liedtke, M. Ludwig, R. Langraf: Intranasally applied Oxytocin: Brain uptake and effects on neuronal ... Annual Meeting 2000, Melbourne R. K. Liedtke, R. Landgraf, I. D. Neumann, Intranasally applied Oxytocin: A novel route of ... Antidepressive effect of oxytocin. This has been predicted with a new biocybernetics model (1998/99), hereafter these effects ...
Neurophysins are binding proteins, of which there are two types: neurophysin I and neurophysin II, which bind to oxytocin and ... Antidiuretic hormone (ADH) and oxytocin are both stored in Herring bodies, but are not stored simultaneously in the same ... Fibers from supraoptic nuclei are concerned with ADH secretion; paraventricular nuclei with oxytocin. This anatomical structure ...
The hormone oxytocin has been identified as inducing uterine contractions, and labour in general. Oxytocin is produced by the ... stimulates production and release of further oxytocin. For example, when oxytocin is released during a contraction of the ... In either form, oxytocin stimulates uterine contractions to accelerate the process of childbirth. Production and secretion of ... du Vigneaud V, Ressler C, Swan JM, Roberts CW, Katsoyannis PG (June 1954). "The synthesis of oxytocin". J. Am. Chem. Soc. 76 ( ...
Greg Miller (2010), The prickly side of oxytocin, Science, 328, 1343 De Dreu, C.K.W., Greer, L.L., Van Kleef, G.A., Shalvi, S ... Using behavioral game theory and neuroscience methods, he showed how the hypothalamic neuropeptide oxytocin modelates self- ... "The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans." Science, 328, 1408 - 1411. Prof. ... Handgraaf, M.J.J. (2011). Oxytocin promotes human ethnocentrism. Proceedings of the National Academy of Sciences USA, 108, 1262 ...
Oxytocin is associated with behaviors involving contact with the child. Increases in oxytocin following high contact ... Oxytocin has been shown to correlate with many aspects of paternal care, but its mechanisms and the systems involved are not ... Oxytocin's interactions with other hormones is thought to be responsible for creating variability in parent behaviors such as ... An increase in levels of oxytocin, glucocorticoids, estrogen and prolactin occur in the paternal brain. These hormonal changes ...
The peptide hormones oxytocin and vasopressin were isolated and their total syntheses first reported in 1954. It is not ... Vincent du Vigneaud was awarded the 1955 Nobel Prize in Chemistry for the total synthesis of the natural polypeptide oxytocin ... du Vigneaud V, Ressler C, Swan JM, Roberts CW, Katsoyannis PG (1954). "The Synthesis of Oxytocin". Journal of the American ...
"Trust, morality -- and oxytocin?". Anderson C, Kraus MW, Galinsky AD, Keltner D (July 2012). "The local-ladder effect: social ... Sasaki JY, Kim HS, Xu J (2011-11-01). "Religion and Well-being The Moderating Role of Culture and the Oxytocin Receptor (OXTR) ... Neuroeconomist Paul Zak studies morality, oxytocin, and trust, among other variables. Based on research findings, Zak ...
He also carried out a series of structure-activity relationships for oxytocin and vasopressin, perhaps the first of their type ... Even before his Nobel-Prize-winning work on elucidating and synthesizing oxytocin and vasopressin via manipulating the AVP gene ... Du Vigneaud, V. (1956). "Trail of sulfur research: from insulin to oxytocin". Science. 123 (3205): 967-974. Bibcode:1956Sci... ... a reference to his work on the peptide hormone oxytocin. Vincent du Vigneaud was born in Chicago in 1901, the son of French ...
Algoe, Sara B.; Kurtz, Laura E.; Grewen, Karen (2017-10-02). "Oxytocin and Social Bonds: The Role of Oxytocin in Perceptions of ... Oxytocin has also been found to play many roles in the bonding between mother and child. In addition to pair-bonding and ... Thus oxytocin may play a flexible role in relationship maintenance, supporting both the feelings that bring us closer and the ... In mammals, oxytocin has been found to be released during childbirth, breastfeeding, sexual stimulation, bonding, and in some ...
"Chemical trust: oxytocin oxymoron?" Am. J. Bioethics 5 (2005): 1. Henry, Rick; Tyler, Anthony O.; Coyne-DeGhett, Stephanie; ...
This condition can also be treated with drugs that increase dopamine, such as oxytocin, along with other drugs. In general, it ... IsHak WW, Berman DS, Peters A (April 2008). "Male anorgasmia treated with oxytocin". The Journal of Sexual Medicine. 5 (4): ... Other drugs which may be helpful in the treatment of this condition include dopamine agonists, oxytocin, phosphodiesterase type ...
Serotonin and oxytocin levels are minimised, and the general immune system shows a level of suppression. Such a pattern is ... Kosfeld, M.; Heinrichs, M; Zak, P.J.; Fischbacher, U.; Fehr, E. (2005). "Oxytocin increases trust in humans". Nature. 435 (7042 ...
The role of oxytocin in autism and schizophrenia has also been researched, and some findings and characterizations of the ... Oxytocin appears to have treatment potential in both autism and schizophrenia, likely including schizotypal personality ... Shilling PD, Feifel D (5 June 2017). "Potential of Oxytocin in the Treatment of Schizophrenia". CNS Drugs. 30 (3): 193-208. doi ... Perez-Rodriguez MM, Derish NE, New AS (2014). "The Use of Oxytocin in Personality Disorders: Rationale and Current Status". ...
AVP2 and oxytocin receptors. AVPR1B maps to chromosome region 1q32 and is a member of the vasopressin/oxytocin family subfamily ... "Vasopressin and Oxytocin Receptors: V1B". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... the first V1b-selective agonist for rat vasopressin/oxytocin receptors". Endocrinology. 148 (9): 4136-46. doi:10.1210/en.2006- ...
Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E (June 2005). "Oxytocin increases trust in humans". Nature. 435 (7042): ...
Oxytocin is also released when were physically intimate. Its tied to making us more trusting, more generous, and friendlier, ... Sometimes called the love hormone, oxytocin plays a role in forming social bonds and trusting other people. Its the hormone ... Studies are investigating if oxytocin can be beneficial in treating some conditions. The hormone is a protein and cannot simply ... Biochemically, you cant live on the 3-to-4-minute oxytocin boost that comes from a single act. ...
Oxytocin and social norms reduce xenophobia Oxytocin and social norms reduce xenophobia Researchers from the University ... In such a prosocial context, oxytocin could increase trust and minimize anxiety - experience shows that the oxytocin level in ... Oxytocin in combination with social norms decreases xenophobia. How can people who tend to have a xenophobic attitude be ... Then half of the group received the bonding hormone oxytocin via a nasal spray, while the other half of the group received a ...
Oxytocin Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before receiving oxytocin injection,. *tell your doctor and pharmacist if you are allergic to oxytocin, any other medications, ... Oxytocin injection is used to begin or improve contractions during labor. Oxytocin also is used to reduce bleeding after ... Oxytocin should not be used to induce labor (to help start the birth process in a pregnant woman), unless there is a valid ...
Intranasal oxytocin may enhance fear extinction therapy for patients with anxiety disorders, early research suggests. ... T]he results of our study indicate that a 24 IU single-dose administration of OXT [oxytocin] increases fear extinction-related ... 7, 2014) Intranasal oxytocin (multiple brands) may enhance fear extinction therapy for patients with anxiety disorders, ... "This study should certainly stimulate further research into the possibility of this role for oxytocin. But at this point, we ...
... buccal oxytocin and buccal desamino-oxytocin / A. N. J. A. de Groot ... [‎et al.]‎  ... WHO/UNICEF/UNFPA joint statement: appropriate storage and management of oxytocin, a key commodity for maternal health  ... WHO recommendation on routes of oxytocin administration for the prevention of postpartum haemorrhage after vaginal birth  ... WHO recommendation on umbilical vein injection of oxytocin for the treatment of retained placenta  ...
... Nature. 2005 Jun 2;435(7042):673-6. doi: 10.1038/nature03701. ... We also show that the effect of oxytocin on trust is not due to a general increase in the readiness to bear risks. On the ... Here we show that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and ... These results concur with animal research suggesting an essential role for oxytocin as a biological basis of prosocial approach ...
... buccal oxytocin and buccal desamino-oxytocin / A. N. J. A. de Groot ... [‎et al.]‎  ... WHO/UNICEF/UNFPA joint statement: appropriate storage and management of oxytocin, a key commodity for maternal health  ... WHO recommendation on routes of oxytocin administration for the prevention of postpartum haemorrhage after vaginal birth  ... WHO recommendation on umbilical vein injection of oxytocin for the treatment of retained placenta  ...
Sales and business experts have always talked about the power of a handshake to make a good first impression and start building a relationship. Researchers at the University of Iowa showed that to be the case when they found that job ...
Side effects of Oxytocin (detailed). Similar questions. What are the nursing considerations when administering oxytocin?. ... Oxytocin - My wife suffered after childbirth from severe vomiting, how can we avoid this next time?. Updated 26 April 2012 1 ... Finally, oxytocin in seminal fluid is discussed and its possible role in respect to the fate of the semen following ejaculation ... What will happen if we give oxytocin to males?. Question posted by lokesh N.RAM on 17 March 2012 ...
We found that oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice (OxtrPBN neurons) are key ... The authors show that oxytocin-receptor-expressing neurons in the parabrachial nucleus are key regulators of fluid homeostasis ... OxtrPBN neurons were directly innervated by oxytocin neurons in the paraventricular hypothalamus (OxtPVH neurons), which ... The PVH also contains oxytocin-expressing neurons that project within the CNS1. The oxytocin receptor (Oxtr) is expressed in ...
p,American neuroeconomist Paul Zak claims that the brain chemical oxytocin is responsible for trust and empathy. ,strong,Mark ... In addition, oxytocin has been shown to facilitate nurturing behaviour in mice and rats: when oxytocin was blocked, the rodents ... He named the extract oxytocin, from the Greek for "quick" and "birth". Within two years, doctors were using oxytocin to bring ... and then tested their blood for oxytocin. He wondered if the human subjects would show a similar spike in oxytocin? ...
High levels of oxytocin cause people to work harder to help the group achieve its goals. We know it is oxytocin causing ... OXYTOCIN and Purpose exemplars In order to make this scalable, I created a survey (that you can try for yourself) that measures ... Oxytocin at work. Of course, I did not start a long research program without some hypotheses. My experiments in the early 2000s ... How Oxytocin Can Make Your Job More Meaningful. Does your job suck? Neuroscience research suggests it might be missing two key ...
... oxytocin could improve some of the social deficits characteristic of people with autism. ... Oxytocin and development:. Doctors in North America and elsewhere often use a synthetic form of oxytocin, called pitocin, to ... The oxytocin receptor - which directs changes in the cell in response to oxytocin - shows considerable variation both within ... Treatment with oxytocin is associated with an increase in methylation, a chemical modification of the oxytocin receptor gene ( ...
Scientists find that the love hormone oxytocin can boost heart cells ability to regenerate, literally helping mend a broken ... Share "Love hormone" oxytocin literally heals a broken heart on Twitter Share "Love hormone" oxytocin literally heals a broken ... "Love hormone" oxytocin literally heals a broken heart. Oxytocin can boost heart cells ability to regenerate. ... "Next, we need to look at oxytocin in humans after cardiac injury. Oxytocin itself is short-lived in the circulation, so its ...
This study was conducted to investigate the preventive effect of oxytocin (OT) on cisplatin-induced neurotoxicity in rats. ... We suggest that oxytocin may have beneficial effects against cisplatin-induced neurotoxicity. ... The effects of oxytocin on plasma TNF-α levels in all groups. Results were presented as mean ± SEM. , different from normal and ... The effects of oxytocin on plasma MDA levels in all groups. Results were presented as mean ± SEM. , different from normal and ...
... (PDF, 63 kB, 15.05.2018) ... Swissmedic informiert über eine befristete Bewilligung zum Vertrieb von 33450 Oxytocin Stricker ad us. vet., Injektionslösung ... www.swissmedic.ch/content/swissmedic/de/home/tierarzneimittel/market-surveillance/out-of-stock-tam/out-of-stock-oxytocin- ...
... oxytocin, helps people become more comfortable and sociable. Zak spent 10 years conducting extensive studies on oxytocin, ... "Touch releases oxytocin," he said. "So Im going to suggest that everyone have at least eight hugs a day." ... This portion of the population has inadequate oxytocin receptors. At the end of the lecture he was asked if these groups can be ... Author Paul Zak talked to a crowd of more than 100 people about his extensive studies on how the chemical, oxytocin, helps ...
Human babies are born helpless, needing to be entirely cared for and protected. Luckily, they are born with all the necessary tools and "instructions" to attain such care for themselves, and to become a loved and loving part of their family and society.. ...
Until oxytocin is properly studied in PWS, it could be dangerous or ineffective to give your loved one oxytocin. As the father ... One important consideration is what form of oxytocin to use. Not all oxytocin is the same. Each form of the drug might be made ... We are aware that oxytocin is available today through the internet or compound pharmacies. Despite the potential of oxytocin, ... It has been nearly one year since we learned of the initial potential of oxytocin and PWSA (USA) began raising funds for the ...
allergy to oxytocin or lidocaine Yes for allergy to oxytocin or lidocaine exclusion criteria 1 ... and this effect is blocked by an oxytocin receptor antagonist (5). Intrathecal injection of oxytocin in normal rats reduces ... and produces analgesia by spinal release of oxytocin, since intrathecal injection of an oxytocin receptor antagonist worsens ... Oxytocin containing cells in the dorsal parvocellular division of the paraventricular nucleus (PVN) project to the spinal cord ...
Oxytocin deficiency has now been found in every known psychological, emotional disorder-AHHD, Autism, Anxiety, Depression, ... Oxytocin, The Essential Hormone for Happiness, Health and Longevity / Menopausal Bliss January 23, 2013. /in Lifestyle and ... Oxytocin-The Essential Hormone for Happiness, Health and Longevity. C. Norman Shealy, M.D., Ph.D. ... Oxytocin deficiency has now been found in every known psychological, emotional disorder-AHHD, Autism, Anxiety, Depression, ...
Oxytocin is a Stem Cell Signal. Oxytocin levels decline with age, and this summer, there was an article in Naturesuggesting ... Trust hormone oxytocin helps old muscle work like new, study finds. *. Muscles Love Oxytocin: So-Called "Hug Hormone" ... A recent study connects loss of oxytocin with frailty and loss of muscle mass in old age. Could it be that oxytocin is the ... Other roles of oxytocin. Oxytocin is known for several other functions. It suppresses our fear and protectiveness. Delivered ...
The hormone oxytocin - known as the love drug or cuddle chemical - plays an important role in pair-bonding, child-rearing ... It turns out, however, that oxytocin is not the common denominator between the two drugs - MDMA may increase oxytocin, while ... But, interestingly, increasing oxytocin may reduce desire for meth. McGregor found that giving rats oxytocin made them lose ... "We published a paper last year showing that baclofen strongly activated oxytocin in the rat brain," says McGregor. And oxytocin ...
To fulfill its many roles, oxytocin has to dock at a protein called the oxytocin receptor, encoded by a gene called OXTR. ... and asked them to sniff either an oxytocin nasal spray or another spray with the same ingredients minus oxytocin - a placebo. A ... Oxytocin is a versatile actor, whose resume includes all sorts of jobs in sex, reproduction, social behaviour and emotions. It ... The Dark Side of Oxytocin, Much More Than Just a "Love Hormone". In fact, it can be the opposite.. Not Exactly Rocket ScienceBy ...
Continuous oxytocin versus intermittent oxytocin for induction of labor: a randomized study. J Matern Fetal Neonatal Med2020;33 ... defined as more than five contractions in 10 minutes in response to oxytocin.567 Different approaches to oxytocin ... Oxytocin discontinuation after the active phase of induced labor: A systematic review. Women Birth2019;32:112-8. doi:10.1016/j. ... Oxytocin discontinuation during active labor in women who undergo labor induction. Am J Obstet Gynecol2012;207:471.e1-8. doi: ...
One of its key players is oxytocin hormone. The neuropeptide, oxytocin (OT), has well-established roles during parturition and ... Several studies suggest that oxytocin is implicated in the central control of responses to stress through modulation of ... 36. Patisaul, H.B., Scordalakes, E.M., Young, L.J. and Rissman, E.F. (2003) Oxytocin, But Not Oxytocin Receptor, Is Regulated ... One of its key players is oxytocin hormone. The neuropeptide, oxytocin (OT), has well-established roles during parturition and ...
... has shown that therapy helps men read emotions more than dosing with oxytocin, which is released naturally and plays an ... Love Isnt The Drug: Oxytocin Supplements Unlikely To Mend Marriages. 4 months, 2 weeks ago ... She said: "Our study serves as an important reminder that oxytocin may not always be the most effective tool when trying to ... Daughters, from the Department of Psychology, says more research is now needed to test oxytocin with women and on those who ...
... determine changes in the salivary oxytocin (OT) level during breast stimulation for promoting the spontaneous onset of labor in ...
This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of holistic, natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional ...
What are oxytocin assays measuring? Epitope mapping, metabolites, and comparisons of wildtype & knockout mouse urine. View ... Oxytocin has become a popular analyte in behavioral endocrinology in recent years, due in part to its roles in social behavior ... Using samples from oxytocin knockout (KO) and wildtype (WT) mice, we find evidence of considerable interference in unextracted ... What are oxytocin assays measuring? Epitope mapping, metabolites, and comparisons of wildtype & knockout mouse urine ...
  • Then half of the group received the bonding hormone oxytocin via a nasal spray, while the other half of the group received a placebo before they were exposed to the donation task established in the first experiment: again the participants decided how much of their 50 euros they wanted to donate to locals or refugees. (uni-bonn.de)
  • A randomized controlled trial of 62 healthy male participants showed that those who received intranasal oxytocin soon after undergoing a fear conditioning task had increased inhibition, or a tamping down, of amygdalar responses during extinction therapy compared with matched peers who received placebo. (medscape.com)
  • The current study included 62 healthy, left-handed male volunteers (mean age, 24.6 years) who were randomly assigned to receive either a 24 IU intranasal dose of synthetic oxytocin or matching placebo. (medscape.com)
  • Dr Acheson, who was not involved with this research, published a study last year in Psychopharmacology that examined 44 healthy participants who underwent a conditioned fear acquisition procedure, after which one half were randomly assigned to receive intranasal oxytocin and the other half, placebo. (medscape.com)
  • She recruited 31 men* and asked them to sniff either an oxytocin nasal spray or another spray with the same ingredients minus oxytocin - a placebo. (discovermagazine.com)
  • A few weeks later, the sprays were swapped so that the men who took oxytocin now took the placebo, and vice versa. (discovermagazine.com)
  • Those who felt more anxious about their relationships took a dimmer view of their mother's parenting styles when they sniffed oxytocin, compared to the placebo. (discovermagazine.com)
  • Some were given intranasal oxytocin, others a placebo and then took some took part in either an accredited emotional training program - known as the Cardiff Emotion Recognition Training program - or a mock training program. (worldhealth.net)
  • The same men also visited the clinic in a monthly interval to receive oxytocin and then later to receive a placebo. (primal-page.com)
  • This review considers the efficacy and safety of oxytocin prophylaxis in the third stage of labour compared with no uterotonics, a placebo, ergot alkaloids, and in combination with ergometrine compared with ergot alkaloids. (cochrane.org)
  • Our results showed that compared to no uterotonics or placebo, oxytocin may reduce the risk of blood loss (quality of evidence: low) and the need for additional uterotonics (quality of evidence: moderate). (cochrane.org)
  • More placebo-controlled, randomised, double-blinded trials are needed to improve the quality of data used to compare oxytocin versus ergot alkaloids. (cochrane.org)
  • The dogs were administered either intranasal oxytocin or placebo and were subjected to a series of behavioral tests. (nationalcanineresearchcouncil.com)
  • We also administered exogenous oxytocin intravenously and intranasally in a triple dummy, within-subject, placebo-controlled design and compared baseline levels and the effects of routes of administration. (elifesciences.org)
  • We suggest that oxytocin may have beneficial effects against cisplatin-induced neurotoxicity. (hindawi.com)
  • Several studies suggest that oxytocin is implicated in the central control of responses to stress through modulation of corticotrophin releasing hormone (CRH). (scirp.org)
  • These various functions suggest that oxytocin may promote health by reducing stress and increasing calm/relaxed states, resulting in improved quality of life and well-being. (mindandlife.org)
  • Both studies, which were presented at the 2016 meeting of the Society of Biological Psychiatry, suggest that oxytocin is a promising potential treatment for drug addictions. (bipolarnews.org)
  • Paul Zak believes oxytocin could help give people more empathy. (theguardian.com)
  • The key, he says, is to kickstart a brain circuit called HOME (human oxytocin-mediated empathy). (theguardian.com)
  • The enhanced empathy enabled by oxytocin allows humans to quickly form teams and work together effectively. (berkeley.edu)
  • A number of studies have suggested that the so-called 'love hormone' oxytocin enhances trust, emotion recognition and even empathy in the typical population. (sfari.org)
  • Zak said he suggested the man seek therapy because there was nothing he could do and told the audience that empathy is part of the effects of oxytocin. (csun.edu)
  • In recent studies in humans, oxytocin has been shown to be associated with increases in prosocial behaviors such as trust, altruism, generosity, cooperation and empathy. (mindandlife.org)
  • Although oxytocin hormone is involved in social behaviors and empathy, it has not been studied in sled dogs. (conicet.gov.ar)
  • Oxytocin is also associated with trust, empathy, and relationship-building. (littlethaifoodataustin.com)
  • We also show that the effect of oxytocin on trust is not due to a general increase in the readiness to bear risks. (nih.gov)
  • This study was conducted to investigate the preventive effect of oxytocin (OT) on cisplatin-induced neurotoxicity in rats. (hindawi.com)
  • The effect of oxytocin compared with ergot alkaloids is uncertain with regards to blood loss (quality of evidence: very low), need for additional uterotonics (quality of evidence: very low), and need for blood transfusion (quality of evidence: very low), but may increase the risk of a third stage greater than 30 minutes (quality of evidence: moderate). (cochrane.org)
  • The effect of oxytocin compared to ergot alkaloids is uncertain with regards to blood loss, need for additional uterotonics, and blood transfusion. (cochrane.org)
  • We found that oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice (Oxtr PBN neurons) are key regulators of fluid satiation. (nature.com)
  • They found that oxytocin had the most potent effect: It increased the EpiPCs' ability to proliferate three-fold compared to untreated cells, a much stronger impact than other molecules previously shown to stimulate EpiPC production in mice. (bigthink.com)
  • Jennifer Bartz from the Mount Sinai School of Medicine has found that oxytocin can have completely opposite effects on the way people behave, depending on how they view their relationships to other people. (discovermagazine.com)
  • Researchers have found that oxytocin, commonly known as the "love hormone" may not be crucial for the social behaviors it's known for. (stanford.edu)
  • Through the combined administration of oxytocin with a social norm, the donations for refugees in those skeptical towards migrants nearly reached half of the sums donated by the group, which showed a positive attitude towards refugees. (uni-bonn.de)
  • Here we show that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions. (nih.gov)
  • Perhaps the administration of oxytocin could be used as an aid in the unrepressing of traumas in the deep abreactive psychotherapies! (primal-page.com)
  • We conducted a study to look at the effects of two mind-body therapies on changes in salivary oxytocin levels in a cancer survivor population with self-reported sleep disturbance. (mindandlife.org)
  • Interestingly, having more receptors in the reward area of the brain enhances the social functions of oxytocin, such as pair-bonding. (sfari.org)
  • Meadow voles have fewer oxytocin receptors in the nucleus accumbens, a brain region that mediates reward, compared with prairie voles. (sfari.org)
  • This portion of the population has inadequate oxytocin receptors. (csun.edu)
  • Oxytocin is conserved in both structure and function across diverse species, suggesting that many of the findings in animal models are likely to be applicable to humans. (sfari.org)
  • These results show that it is likely that the stimulation by oxytocin of EpiPC production is evolutionary [sic] conserved in humans to a significant extent. (bigthink.com)
  • Zak said his studies in Papua New Guinea provided evidence that oxytocin is a chemical that affects humans the same way universally. (csun.edu)
  • Purpose: There is a strong experimental basis to support the study of oxytocin by the spinal route for analgesia in humans. (centerwatch.com)
  • Rationale: We anticipate that oxytocin will be effective after spinal injection in humans against chemical induced hypersensitivity states. (centerwatch.com)
  • Administration of MDMA increases plasma oxytocin levels in humans," says Gillinder Bedi, Columbia University assistant professor of clinical psychology and lead author of new research on the effects of MDMA and methamphetamine, which I reported previously here . (time.com)
  • Here we show that oxytocin, a neuropeptide also known as the love hormone, is capable of activating heart repair mechanisms in injured hearts in zebrafish and human cell cultures, opening the door to potential new therapies for heart regeneration in humans," said Dr Aitor Aguirre, an assistant professor at the Department of Biomedical Engineering of Michigan State University, and the study's senior author. (neurosciencenews.com)
  • Oxytocin has similar effects for humans as for mice, however, it is not yet clear if the hormone influences the human version of this mouse interaction, or if it works through a similar population of interneurons. (nutritionreview.org)
  • Our findings question the use of single measurements of baseline oxytocin concentrations in saliva and plasma as valid trait markers of the physiology of the oxytocin system in humans. (elifesciences.org)
  • Sometimes called 'the love hormone,' oxytocin plays a role in forming social bonds and trusting other people. (cedars-sinai.org)
  • Researchers at University Hospital Bonn have shown in a new study that the bonding hormone oxytocin together with social norms significantly increases the willingness to donate money to refugees in need, even in people who tend to have a skeptical attitude towards migrants. (uni-bonn.de)
  • In the male mammal, the small peptide hormone oxytocin is produced in similar quantities within the hypothalamo-pituitary magnocellular system as in the female, yet for the male little is known about the physiology associated with this hormone. (drugs.com)
  • The "love hormone" oxytocin creates social bonds and generates the pleasurable feelings associated with art , exercise, and sex . (bigthink.com)
  • The hormone oxytocin - known as the "love drug" or "cuddle chemical" - plays an important role in pair-bonding, child-rearing and social behavior. (time.com)
  • Often called "the love hormone," oxytocin is a powerful neurotransmitter that regulates social interaction, pair bonding, milk release, uterine contractions and sexual reproduction. (salimetrics.com)
  • T he headlines of a recent article in MedlinePlus announced that recent evidence has shown that the 'Love Hormone', oxytocin, may boost our 'memories of mama' -- either good ones or bad ones. (primal-page.com)
  • The 'love' hormone oxytocin is released in the brain during sexual activity and also when a baby suckles. (thenakedscientists.com)
  • Does 'Love Hormone' Oxytocin Play a Role in Pair Bonding? (mental-health.news)
  • The 'love hormone' oxytocin has long been thought key to behaviours including pairing up with a partner and nurturing offspring, but a new study in prairie voles is raising doubts. (panatimes.com)
  • Salimetrics launches validated and optimized salivary oxytocin assay for researchers sending samples for testing to the Salimetrics SalivaLab. (salimetrics.com)
  • Today, Salimetrics' strong bond with the salivary bioscience community grows even stronger with the launch of a high sensitivity salivary oxytocin assay, now available through the Salimetrics SalivaLab testing service. (salimetrics.com)
  • We're proud to make reliable testing of salivary oxytocin easy and readily accessible to investigators for the first-time. (salimetrics.com)
  • Concurrent research provides a robust background that highlights salivary oxytocin as an important biomarker for researching emotional, cognitive, and other behavioral fields of interest. (salimetrics.com)
  • Investigators can visit the Salimetrics Website to learn more about salivary oxytocin, now available through the Salimetrics SalivaLab, or to submit a request for a quote . (salimetrics.com)
  • The availability of oxytocin testing now provides an additional opportunity to facilitate research that will continue to advance the cutting edge of better salivary bioscience. (salimetrics.com)
  • Single measurements of salivary and plasmatic oxytocin are used as indicators of the physiology of the oxytocin system. (elifesciences.org)
  • However, questions remain about whether they are sufficiently stable to provide valid trait markers of the physiology of the oxytocin system, and whether salivary oxytocin can accurately index its plasmatic concentrations. (elifesciences.org)
  • Using radioimmunoassay, we measured baseline plasmatic and/or salivary oxytocin from two independent datasets. (elifesciences.org)
  • Salivary oxytocin is a weak surrogate for plasmatic oxytocin. (elifesciences.org)
  • The increases in salivary oxytocin observed after intranasal oxytocin most likely reflect unabsorbed peptide and should not be used to predict treatment effects. (elifesciences.org)
  • 2020. Evaluating changes in salivary oxytocin and cortisol following positive reinforcement training in two adult male western lowland gorillas (Gorilla gorilla gorilla). (awionline.org)
  • As has been demonstrated at Zak's lab in California, one way to achieve this is by getting volunteers to inhale on an oxytocin nasal spray. (theguardian.com)
  • The potential problem with long-term intranasal oxytocin is nasal mucosa atrophy and it is not inexpensive. (normshealy.com)
  • It turns out that oxytocin has been used as a nasal spray for emotional/mental symptoms and additionally for local application to the clitoris to help vaginal dryness. (normshealy.com)
  • Men who reported their mothers as caring, before receiving a nasal administration of of oxytocin, felt even more highly of them after the shot. (primal-page.com)
  • Oxytocin injection is used to begin or improve contractions during labor. (medlineplus.gov)
  • If oxytocin injection is given to induce labor or to increase contractions, it is usually given intravenously with medical supervision in a hospital. (medlineplus.gov)
  • Your doctor may adjust your dose of oxytocin injection during your treatment, depending on your contraction pattern and on the side effects that you experience. (medlineplus.gov)
  • Talk to your doctor about how you are feeling during your treatment with oxytocin injection. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to oxytocin, any other medications, or any of the ingredients in oxytocin injection. (medlineplus.gov)
  • Your doctor will probably not give you oxytocin injection. (medlineplus.gov)
  • Oxytocin injection may cause side effects. (medlineplus.gov)
  • Your doctor may order certain lab tests to check your body's response to oxytocin injection. (medlineplus.gov)
  • Ask your pharmacist any questions you have about oxytocin injection. (medlineplus.gov)
  • Noxious stimulation activates these cells via the A1 noradrenergic relay in the pons (2) and produces analgesia by spinal release of oxytocin, since intrathecal injection of an oxytocin receptor antagonist worsens pain behaviors from peripheral inflammation (3). (centerwatch.com)
  • Intrathecal injection of oxytocin in normal rats reduces dorsal horn neuronal responses to noxious stimuli (6) as well as behavioral responses to noxious thermal (3), mechanical (3), and chemical (7) stimuli. (centerwatch.com)
  • Finally, intrathecal injection of oxytocin in rat models of chronic pain also reduces dorsal horn neuronal responses to sensory stimulation (6) as well as behavioral responses to thermal (5) and mechanical (7) stimuli. (centerwatch.com)
  • Post-partum hemorrhage is a significant and challenging global health issue, so we are very excited to be working with Vectura on a low cost, heat stable, and non-invasive approach to deliver oxytocin, overcoming existing limitations of current injection products," added Professor Michelle McIntosh, project lead at MIPS, in the press release. (pharmtech.com)
  • Two recent studies suggest that in rats, an injection of oxytocin can prevent drug-seeking behavior. (bipolarnews.org)
  • Healthcare providers perceived the ease of use and lack of dependence on cold storage as the main enablers for IOT compared with the current gold standard oxytocin injection. (bmj.com)
  • The objective of this study was to investigate the effect of IV injection of oxytocin (OT) on serum and seminal plasma levels of oestradiol (E2), testosterone (T), dehydroepiandrosterone sulphate (DHEA-S), and semen characteristics in rams. (tubitak.gov.tr)
  • In addition to boosting oxytocin and dopamine, being kind can also increase serotonin, a neurotransmitter that helps regulate mood. (cedars-sinai.org)
  • It appears that pairing oxytocin with a social norm can help counter the effects of xenophobia by enhancing altruistic behavior toward refugees. (uni-bonn.de)
  • This finding provided some of the first evidence that oxytocin may be a regulator of general social behavior. (sfari.org)
  • To directly test the function of oxytocin on social behavior, Larry Young , professor of neuroscience at Emory University in Atlanta, Georgia, examined genetically engineered mice lacking the oxytocin protein. (sfari.org)
  • Sue Carter and colleagues have also linked oxytocin to affiliative behavior and pair-bonding in a non-traditional animal model: the prairie vole. (sfari.org)
  • Because social behavior is complex, non-human primates should provide unique insights into the role of oxytocin in mediating social behavior. (sfari.org)
  • We were able to get rid of a big part of the social behavior induced by MDMA [by blocking oxytocin]," he says. (time.com)
  • The study - in collaboration with Cardiff University - has shown that therapy helps men read emotions more than dosing with oxytocin, which is released naturally and plays an important role in regulating behavior, such as emotions and personal relationships. (worldhealth.net)
  • Oxytocin has become a popular analyte in behavioral endocrinology in recent years, due in part to its roles in social behavior, stress physiology, and cognition. (biorxiv.org)
  • Oxytocin is a hormone produced in an area of the brain known as the hypothalamus, whose release activates a variety of brain regions resulting in many different functions, including birth (labor), breast feeding (lactation), maternal behavior, parental care, social bonding, affiliation (such as couples being together), and well-being. (mindandlife.org)
  • To determine how these neurons, dubbed oxytocin receptor interneurons or OxtrINs, affected behavior when activated by oxytocin, she silenced only this class of interneurons and, in separate experiments, blocked the receptor's ability to detect oxytocin in some females. (nutritionreview.org)
  • Oxytocin responses have been studied in many parts of the brain, and it is clear that it, or other hormones like it, can impact behavior in different ways, in different contexts and in response to different physiological cues," he says. (nutritionreview.org)
  • This paper is included because it examines a possible mechanism - metabolizing of oxytocin - which could explain differences in social behavior among dogs and which may extend to such differences among people. (nationalcanineresearchcouncil.com)
  • This suggests that the gaze shifting behavior may be linked to something other than social reassurance, or that oxytocin affects other sorts of emotional responses than the target of the investigation here, among other possibilities, and underlies the complexity of labeling a specific behavior as a surrogate for an aspect of personality. (nationalcanineresearchcouncil.com)
  • Doctors in North America and elsewhere often use a synthetic form of oxytocin, called pitocin, to induce labor, even though little is known about the long-term consequences for either mother or baby, according to Sue Carter, co-director of the Brain-Body Center at the University of Illinois at Chicago. (sfari.org)
  • One important consideration is what form of oxytocin to use. (pwsausa.org)
  • The oxytocin receptor - which directs changes in the cell in response to oxytocin - shows considerable variation both within and among species, however. (sfari.org)
  • 4 The stimulation requires a delicate balance between the wish for progression of labour and the risks to the fetus and mother of uterine hyperstimulation, defined as more than five contractions in 10 minutes in response to oxytocin. (bmj.com)
  • Under the influence of oxytocin, the individuals who tended to show a positive attitude towards refugees doubled their donations to both the locals and the refugees. (uni-bonn.de)
  • The present review summarizes what is known about the function of oxytocin in the male mammal and tries to take account of both central and systemic effects, and those linked with a local production of oxytocin within the male reproductive organs. (drugs.com)
  • This molecule had not been associated with human social behaviors until my group developed a technique to stimulate and measure the brain's acute production of oxytocin through rapid blood draws. (berkeley.edu)
  • Oxytocin is best known for its use in inducing labour. (theguardian.com)
  • Today, synthetic oxytocin, also called Pitocin or Syntocinon, is often used to induce labour and to help new mothers who have trouble with milk let-down. (theguardian.com)
  • Objective To determine whether discontinuing oxytocin stimulation in the active phase of induced labour is associated with lower caesarean section rates. (bmj.com)
  • Participants 1200 women stimulated with intravenous oxytocin infusion during the latent phase of induced labour. (bmj.com)
  • Intervention Women were randomly assigned to have their oxytocin stimulation discontinued or continued in the active phase of labour. (bmj.com)
  • 5 6 7 Different approaches to oxytocin administration have been suggested, such as pulsatile or intermittent administration, 8 9 an automatic feedback system, 10 high versus low dose, 11 and/or discontinuation of the stimulation when the active phase of labour is reached. (bmj.com)
  • Four meta-analyses and two more recent studies have suggested that once a woman is in active labour, the labour will continue even if oxytocin stimulation is stopped, resulting in a lower risk of caesarean section for fetal indications secondary to uterine hyperstimulation. (bmj.com)
  • Oxytocin may reduce blood loss and the need for additional uterotonics when given prophylactically in the third stage of labour, and therefore could be considered as a component of AMTSL. (cochrane.org)
  • How much synthetic oxytocin is infused during labour? (bournemouth.ac.uk)
  • OBJECTIVE: To compare synthetic oxytocin infusion regimens used during labour, calculate the International Units (IU) escalation rate and total amount of IU infused over eight hours. (bournemouth.ac.uk)
  • SAMPLE: National, regional or institutional-level regimens on oxytocin for induction and augmentation labour. (bournemouth.ac.uk)
  • CONCLUSION: Current variations in oxytocin regimens for induction and augmentation of labour are inexplicable. (bournemouth.ac.uk)
  • Most of you have heard me going on and on about the power of oxytocin in healing, bonding and labour. (birthbliss.ca)
  • IMSEAR at SEARO: Transplacental asymptomatic hyponatremia following oxytocin infusion during labour. (who.int)
  • The costs of induction of labour by prostaglandin E2 or oxytocin : refining the estimates / Linda Davies, Michael Drummond. (who.int)
  • Oxytocin clearly increases generosity towards those in need, however, if this altruistic fundamental attitude is missing, the hormone alone cannot create it," says Hurlemann. (uni-bonn.de)
  • T]he results of our study indicate that a 24 IU single-dose administration of OXT [oxytocin] increases fear extinction-related frontal brain activity and connectivity, and dampens fear and safety-related amygdalar activity along with electrodermal responses," the investigators, led by Monika Eckstein, PhD student from the Department of Psychiatry and the Division of Medical Psychology at the University of Bonn, Germany, write. (medscape.com)
  • In our study, we hypothesized that the mind-body therapies would increase oxytocin levels, which would be associated with improvements in sleep, increases in quality of life and well-being, and reduced stress. (mindandlife.org)
  • Physiological changes following PRT, for example, increases in oxytocin (OXT) and/or decreases in cortisol. (awionline.org)
  • Physical contact also increases a mother's oxytocin levels, which can help breastmilk flow. (cdc.gov)
  • The oxytocin-MDMA link has also been shown in rats, according to Iain McGregor, professor of psychopharmacology at the University of Sydney. (time.com)
  • In previous rat studies, researchers have found that the release of oxytocin is not involved in the high of amphetamine (whose effects are more similar to those of methamphetamine than MDMA's are) - and that blocking the hormone had no effect on rats' desire for the drug. (time.com)
  • Conversely, blocking oxytocin did decrease rats' interest in MDMA, suggesting that the hormone may be involved in ecstasy's "high. (time.com)
  • McGregor found that giving rats oxytocin made them lose interest in taking methamphetamine. (time.com)
  • In the present study, we reveal that oxytocin is released within the brain, specifically within the hypothalamic paraventricular nucleus, of male rats during mating with a receptive female. (dericbownds.net)
  • The participants concluded that researchers should aim to better understand the oxytocin system in people. (sfari.org)
  • Researchers identified oxytocin more than 100 years ago when they discovered that it regulates uterine contraction and milk ejection. (sfari.org)
  • Bales and Young are mapping the distribution of the oxytocin receptor within the titi monkey brain, which could help researchers understand where oxytocin functions in the human brain. (sfari.org)
  • The researchers wanted to determine if oxytocin was necessary for heart regeneration in a living organism. (bigthink.com)
  • To determine if that burst of love hormone is necessary for regenerating heart tissue, the researchers injected some of the cyro-injured zebrafish with an oxytocin inhibitor. (bigthink.com)
  • That would allow the researchers to enroll more patients and do more testing which could provide more definitive information regarding oxytocin. (pwsausa.org)
  • Researchers have found that the loved-up effects of ecstasy (MDMA) are due at least in part to oxytocin. (time.com)
  • Now, researchers from Michigan State University show that in zebrafish and human cell cultures, oxytocin has yet another, unsuspected, function: it stimulates stem cells derived from the heart's outer layer (epicardium) to migrate into its middle layer (myocardium) and there develop into cardiomyocytes, muscle cells that generate heart contractions. (neurosciencenews.com)
  • The researchers hypothesized that the different jobs that historical ancestors of these modern breeds were selected for would affect their responses both to the tests in general and to their sensitivity to oxytocin, a chemical the authors expected to facilitate social contact. (nationalcanineresearchcouncil.com)
  • Kovács, Kis, Pogány, Koller, & Topál (2016) studied the effects of oxytocin on social cognition in dogs, specifically breed differences on task performance previously used to demonstrate social cognition. (nationalcanineresearchcouncil.com)
  • Oxtr PBN neurons were directly innervated by oxytocin neurons in the paraventricular hypothalamus (Oxt PVH neurons), which mildly attenuated fluid intake. (nature.com)
  • To evaluate the role of oxytocin-related neural circuitry on ingestive behaviors, we generated mice expressing Cre recombinase at the Oxtr locus (Supplementary Fig. 1 ). (nature.com)
  • To characterize the effects of oxytocin on Oxtr PBN neurons, we recorded the activity of fluorescently labeled cells in brain slices and observed that bath application of Thr 4 ,Gly 7 -oxytocin (TGOT), a selective Oxtr agonist, efficiently activated Oxtr PBN neurons, and this activation was blocked by coadministration of atosiban (oxytocin-receptor antagonist), which confirmed the specificity of the activation (Fig. 1c and Supplementary Fig. 2d ). (nature.com)
  • To fulfill its many roles, oxytocin has to dock at a protein called the 'oxytocin receptor', encoded by a gene called OXTR. (discovermagazine.com)
  • The neural basis of smile authenticity judgments and the potential modulatory role of the oxytocin receptor gene (OXTR). (cdc.gov)
  • Glu 1.35 in transmembrane helix 1 (TM1) of the human oxytocin receptor (OTR) is absolutely conserved in all OTRs cloned to date. (monash.edu)
  • There is "an inverse correlation between plasma oxytocin and the volume of the right amygdala and the right hippocampus, 2 brain areas implicated in fear and anxiety. (normshealy.com)
  • Oxytocin-expressing neurons are located in the paraventricular nucleus of the hypothalamus (PVH) and supraoptic nucleus (SON) and project axons to the posterior pituitary to release oxytocin peripherally 1 . (nature.com)
  • Enjoy and remember, think soft thoughts…they release oxytocin! (birthbliss.ca)
  • I did not know that soft words release oxytocin, so there we have it…another reason why it's sooooo important for HypnoBirthing parents to embrace the terminology. (birthbliss.ca)
  • I proved that the brains of indigenous people produce oxytocin and this makes heavy work light. (berkeley.edu)
  • In all the emotional disorders listed at the beginning, intranasal sprays of oxytocin have been proven to improve the emotional problem, BUT intranasal sprays have to be done 4 times a day, and have no ability to restore the brain's ability to produce oxytocin. (normshealy.com)
  • It turns out, however, that oxytocin is not the common denominator between the two drugs - MDMA may increase oxytocin, while methamphetamine may not affect it directly. (time.com)
  • Effects of Exogenous Oxytocin on Serologic and Seminal Steroids and Se" by TANZER BOZKURT, GAFFARİ TÜRK et al. (tubitak.gov.tr)
  • Similarly, direct electrical stimulation of the PVN reduces behavioral sensitivity in a model of chronic neuropathic pain, and this effect is blocked by an oxytocin receptor antagonist (5). (centerwatch.com)
  • Furthermore, blockade of the activated brain oxytocin system by central administration of an oxytocin receptor antagonist immediately after mating prevents the anxiolytic effect of mating, while having no effect in nonmated males. (dericbownds.net)
  • The purpose of this study is to determine the effect of intrathecal oxytocin on areas and intensity of hyperalgesia and allodynia induced by topical capsaicin. (centerwatch.com)
  • Objectives: Determine the effect of intrathecal oxytocin on areas and intensity of hyperalgesia and allodynia induced by topical capsaicin. (centerwatch.com)
  • The neuropeptide, oxytocin (OT), has well-established roles during parturition and lactation. (scirp.org)
  • The neuropeptide oxytocin has been shown to exert multiple functions in male and female reproduction, and to play a key role in the regulation of emotionality after its peripheral and central release, respectively. (dericbownds.net)
  • Objective This study assessed the potential operational feasibility and acceptability of a heat-stable, inhaled oxytocin (IOT) product for community-based prevention of postpartum haemorrhage in Myanmar. (bmj.com)
  • This is the first qualitative inquiry exploring the operational feasibility and acceptability of a future heat-stable, inhaled oxytocin (IOT) product for community-based prevention of postpartum haemorrhage in Myanmar to inform product development. (bmj.com)
  • Contractility of uterine smooth muscle can be controlled by hormonal and neural factors examples progesterone, oxytocin and prostaglandin F2α (PGF2α) (hormonal) and acetylcholine (neural). (medsci.org)
  • Direct electrical stimulation of the PVN reduces dorsal horn neuronal responses to noxious stimulation, and this is blocked by administration of sequestering antibody for oxytocin (4). (centerwatch.com)
  • Conclusions In a setting where monitoring of the fetal condition and the uterine contractions can be guaranteed, routine discontinuation of oxytocin stimulation may lead to a small increase in caesarean section rate but a significantly reduced risk of uterine hyperstimulation and abnormal fetal heart rate patterns. (bmj.com)
  • 1 2 3 This often includes stimulation with oxytocin. (bmj.com)
  • No evidence indicated gastrin alterations or muscular damage from touristic mushing, but an oxytocin increase would indicate a stimulation of the brain reward system. (conicet.gov.ar)
  • The pituitary also secretes endorphins (pronounced: en-DOR-fins), chemicals that act on the nervous system and reduce feelings of pain. (kidshealth.org)
  • To get more specific, research has shown that crying releases unique hormones in the body , such as oxytocin and endorphins, which help relieve physical and psychological pain while reducing other stress-related hormones such as adrenocorticotropic hormone (ACTH). (mindbodygreen.com)
  • The second is that single measures provide reliable estimates of baseline levels of endogenous oxytocin in plasma or saliva. (elifesciences.org)
  • Currently, we lack robust evidence that single measures of endogenous oxytocin in saliva and plasma at rest are stable enough to provide a valid trait marker of the activity of the oxytocin system in healthy individuals. (elifesciences.org)
  • Mechanical methods work by directly causing cervical dilation and also by releasing endogenous prostaglandins and oxytocin. (medscape.com)
  • The Effect on the Birth Process of Endogenous Oxytocin Release Via Coitus at Home in Pregnant Women in the Latent Phase. (bvsalud.org)
  • This study was conducted to determine the effect of endogenous oxytocin release via coitus at home on the delivery process in pregnant women who were not hospitalized in the latent phase. (bvsalud.org)
  • Vectura, an inhalation contract development and manufacturing organization (CDMO), announced on Sept. 14, 2020 that it has partnered with Monash University's Institute of Pharmaceutical Sciences (MIPS) for the development of an inhaled oxytocin delivered by a dry-powder inhaler to prevent postpartum hemorrhage (PPH) in childbirth. (pharmtech.com)
  • The men also provided blood samples to record their oxytocin levels, the hormone that in women triggers labor and lactation and in men has a role in moving sperm. (littlethaifoodataustin.com)
  • While Blessed Thistle Mediterranean herb and dandelion-like blossoms stimulate healthy immune response and increase prolactin, the oxytocin hormones stimulate lactation, using anethole substances from fennel seed that produce breast milk secretion. (athleticinsight.com)
  • If not, further pharmacologic agents (i.e. oxytocin) can be used for induction. (medscape.com)
  • Again, the need for amniotomy , labor induction with oxytocin , analgesics and episiotomy decreased. (bvsalud.org)
  • Once detected, H-Mole is removed through dilatation and curettage, but if discovered later induction by oxytocin may be done to expel the abnormal growth. (healthwatchcenter.com)
  • We know it is oxytocin causing cooperation because my colleagues and I developed a way to safely infuse synthetic oxytocin into living human brains. (berkeley.edu)
  • It is crucial that the appropriate minimum infusion regimen is administered because synthetic oxytocin is a potentially harmful medication with serious consequences for women and babies when inappropriately used. (bournemouth.ac.uk)
  • Results A total of 607 women were assigned to discontinuation and 593 to continuation of the oxytocin infusion. (bmj.com)
  • METHODS: Data on oxytocin IU dose, infusion fluid amount, start dose, escalation rate and maximum dose were collected. (bournemouth.ac.uk)
  • Estimating the total amount of oxytocin IU received by labouring women, alongside the institution's mode of birth and neonatal outcomes, may deepen our understanding and be the way forward to identifying the optimal infusion regimen. (bournemouth.ac.uk)
  • When we finally speak, Zak tells me that "oxytocin is primarily a molecule of social connection. (theguardian.com)
  • Injecting oxytocin into the brain of prairie voles induces formation of these bonds and injecting a molecule that blocks the oxytocin receptor prevents them, studies have shown. (sfari.org)
  • Prior patent literature and recent proteomic research in plasma and serum has appreciated that oxytocin exists as a cyclic active molecule and also in a pool with disulfides linked to other proteins. (salimetrics.com)
  • Aguirre and his team identified 15 candidates, including growth hormone (which is undergoing clinical studies to determine muscle regeneration in severely burned patients), prolactin (which regulates liver regeneration in mice), and oxytocin (which is necessary for muscle maintenance and regeneration ). (bigthink.com)
  • Because oxytocin is most involved in social behaviors of females, we decided to focus our experiments on females. (nutritionreview.org)
  • Google Académico, fueron incluidas únicamente las publicaciones que se encontraron a texto completo, en español, inglés y portugués durante los años 2014 al 2022. (bvsalud.org)
  • According to their study , oxytocin stimulates stem cells to develop into cardiomyocytes - the muscle cells that generate heart contractions and which are damaged during a heart attack. (bigthink.com)
  • L istening to Paul Zak extol the virtues of oxytocin, the "love hormone", is like hearing a preacher sing the praises of the Promised Land. (theguardian.com)
  • Oxytocin, the "love hormone", is one of those blood factors that we have less of as we age. (hplusmagazine.com)
  • Describing oxytocin as the "hormone of love" is like describing a computer as a "writing tool" - it does other things too, some of which aren't pleasant. (discovermagazine.com)
  • Oxytocin, a hormone connected with bonding and love, could help to heal damage following a heart attack. (neurosciencenews.com)
  • Oxytocin, the body's natural love potion, helps couples fall in love, makes mothers bond with their babies, and encourages teams to work together. (nutritionreview.org)
  • As you might recall, oxytocin is the "love hormone," but it is also referred to as the "anti-stress" hormone. (birthbliss.ca)
  • He has also been coined "Dr. Love" based on his research on how oxytocin influences economic decisions. (birthbliss.ca)
  • Levels of oxytocin, the so-called love hormone, and activation in certain parts of the brain may help predict how men will behave as parents, a small study in Developmental Psychobiology showed. (littlethaifoodataustin.com)
  • Also known as the 'love drug' because when you hug someone or feel a sense of belonging your brain reacts with Oxytocin. (nofun.io)
  • Therefore, we love to give back to others and make ourselves happy with an oxytocin boost. (phytogenius.com)
  • Oxytocin isn't love. (timdenning.com)
  • Within two years, doctors were using oxytocin to bring on childbirth contractions. (theguardian.com)
  • Oxytocin is a uterotonic medication that promotes increased uterine tone and contractions, and is commonly administered immediately following delivery of the infant's shoulder as part of AMTSL. (cochrane.org)
  • Oxytocin acts on SMOOTH MUSCLE CELLS , such as causing UTERINE CONTRACTIONS and MILK EJECTION . (bvsalud.org)
  • Updated Nov. 7, 2014) Intranasal oxytocin (multiple brands) may enhance fear extinction therapy for patients with anxiety disorders, preliminary research suggests. (medscape.com)
  • The findings on oxytocin may well lead to some new treatments for autism, McGregor suggests, given that autistic people have difficulty making the oxytocin-driven connection between people and pleasure. (time.com)
  • Our current understanding of how oxytocin sprays work suggests that, in their current form, it may not be a practical solution. (worldhealth.net)
  • Because the literature suggests different oxytocin response timing to different stimulus, Salimetrics recommends running a small pilot study to determine peak sample collection timing. (salimetrics.com)
  • Oxytocin, the hormone that promotes emotional bonding, also regulates a variety of behaviors. (bipolarnews.org)
  • In addition, the oxytocin reversed changes in the brain's glutamate signaling pathway that were caused by cocaine use. (bipolarnews.org)
  • That was a single "dose", and there are numerous studies that demonstrate improvement in all negative emotions with continuing inhalation of oxytocin. (normshealy.com)
  • Main Outcome Measures Oxytocin IU dose infused. (bournemouth.ac.uk)
  • When used as prophylaxis within 10 min after vaginal delivery usually at the dose of 1 g IV, in addition to standard prophylaxis with oxytocin, tranexamic acid reduced the risk of primary PPH and the mean post-partum blood loss However there are no studies that evaluated the impact of TA on blood loss after vaginal deliveries with an episiotomy. (centerwatch.com)
  • Dale later discovered that oxytocin stimulated the release, or let-down, of mother's milk by contracting the smooth-muscle cells around the mammary glands. (theguardian.com)
  • Still, the findings provide "important mechanistic insights into beneficial effects of oxytocin in fear extinction, which is thought to be the key learning process underlying cognitive behavioral therapy (exposure) of anxiety disorders," said Dr Hurlemann. (medscape.com)
  • And it supports some findings from our own laboratory suggesting that oxytocin can facilitate aspects of fear extinction learning," he added. (medscape.com)
  • In this webinar we will have two panelists discussing the role of oxytocin from findings in Nigeria and India. (rhsupplies.org)
  • These findings provide direct evidence for an essential role of an activated brain oxytocin system mediating the anxiolytic effect of mating in males. (dericbownds.net)
  • My experiments in the early 2000s on human cooperation were the first to identify the key role played by the neurochemical oxytocin. (berkeley.edu)
  • Study limitations cited included the fact that fear acquisition and extinction were performed on the same day instead of being spread out over several days and that it is not known whether the effects of oxytocin can be extrapolated from the type of fear conditioning used here to other types, such as evaluative conditioning. (medscape.com)
  • For now, Bartz isn't sure why oxytocin can have such different effects. (discovermagazine.com)
  • In particular, the beneficial effects of oxytocin that we want to bolster only last for several hours. (worldhealth.net)
  • Oxytocin (OXT), a neurohypophyseal hormone, has a wide range of behavioral effects outside its classic peripheral endocrine functions. (erowid.org)
  • This study, which seemed to contradict our established knowledge of the effects of oxytocin, was described in the November 29, 2010 journal, Proceedings of the National Academy of Science . (primal-page.com)
  • Investigating oxytocin in cancer survivors could be important, given cancer survivors' high levels of distress, depression, and anxiety, as well as poor sleep, possibly due to the effects of cancer treatment and worries about cancer recurrence. (mindandlife.org)
  • Regarding the effects of the mind-body therapies, after controlling for baseline differences among groups, post-treatment oxytocin levels were significantly higher in the mind-body bridging group as compared with those in the control group. (mindandlife.org)
  • Although exogenously application of oxytocin (OT) hormone researches are increasing for the effects of brain and related pathophysiologies, epilepsy-related studies are highly limited. (mendeley.com)
  • Therefore, in this study, effects of BPA, vinclozolin and DDT-only and in combination with uterotonins (PGF-2α, acetylcholine and oxytocin) on the force and pattern of uterine contraction were observed. (medsci.org)
  • As a result of that research, McGregor and his colleagues are now testing intranasal oxytocin to help reduce addiction in alcoholics and heavy pot smokers. (time.com)
  • Dr. Katie Daughters says the research, which was carried out with colleagues in Cardiff, revealed we need to know more about oxytocin before using it as a treatment. (worldhealth.net)
  • Writing in Science , Azabu University researcher Miho Nagasawa and her colleagues compared urine oxytocin levels in a group of dogs and their owners before and after the spent time interacting with each other. (thenakedscientists.com)
  • But Zak goes further, arguing that many of the social and political issues that currently seem so intractable could be solved if only we could find a way of raising people's basal levels of oxytocin. (theguardian.com)
  • High levels of oxytocin cause people to work harder to help the group achieve its goals. (berkeley.edu)
  • Paul Zak speaks about his research on oxytocin levels in the blood which when increased, generate more positive human behaviors. (csun.edu)
  • Zak showed several clips on studies he had conducted from measuring oxytocin levels in blood before and after a wedding to mishaps during his research in Papua New Guinea. (csun.edu)
  • Through all of his studies, Zak measured oxytocin levels through blood samples. (csun.edu)
  • Oxytocin levels decline with age, and this summer, there was an article in Nature suggesting that it may be one of those signals that help to keep us young. (hplusmagazine.com)
  • Maybe when you get high levels of oxytocin, plus high levels of dopamine, you have a motivational situation where you are strongly oriented toward [people]," McGregor says. (time.com)
  • Overall, oxytocin levels did not differ between females and males and were not correlated with age. (mindandlife.org)
  • 400 UI/L), low and stable levels of gastrin (9.4 ± 8.8 pg/mL), and a slight increase in oxytocin (23%) after mushing activities. (conicet.gov.ar)
  • Those with higher oxytocin levels in their blood had a more baby-led approach. (littlethaifoodataustin.com)
  • This is the first study to analyze oxytocin levels and brain activation in fathers. (littlethaifoodataustin.com)
  • Oxytocin is in a class of medications called oxytocic hormones. (medlineplus.gov)
  • Different strategies have been described for preventing and treatment PPH, including active management of the third stage of labor, among them uterine massage and controlled cord traction in addition to oxytocin and the use of Tranexamic acid (TA) as PPH treatment Tranexamic acid (TA) is a lysine analog, which acts as an antifibrinolytic via competitive inhibition to the binding of plasmin and plasminogen to fibrin. (centerwatch.com)
  • Using this protocol, we showed that when one is intentionally trusted, even by a stranger, the brain produces oxytocin. (berkeley.edu)
  • In fact, this response is graded: The more trust one is shown by others, the more oxytocin is released in the brain. (berkeley.edu)
  • Within three days after cryo-injury, oxytocin RNA expression in the brain increased 18-fold and lasted for at least seven days, suggesting that a burst of oxytocin is released from the brain into the bloodstream after cardiac injury over a sustained period. (bigthink.com)
  • We published a paper last year showing that baclofen strongly activated oxytocin in the rat brain," says McGregor. (time.com)
  • Within some profiles from the outer layer of the brain known as the cortex, she saw an intriguing protein: a receptor that responds to oxytocin. (nutritionreview.org)
  • Prairie voles still form social bonds without oxytocin sensors in the brain. (newscientist.com)
  • Intranasal oxytocin modulates brain responses to voice-identity recognition in typically developing individuals, but not in ASD. (mpg.de)
  • The brain releases Oxytocin in experiences associated with trust, friendship and connection. (nofun.io)
  • These results concur with animal research suggesting an essential role for oxytocin as a biological basis of prosocial approach behaviour. (nih.gov)
  • Finally, oxytocin in seminal fluid is discussed and its possible role in respect to the fate of the semen following ejaculation. (drugs.com)
  • I also went as far from the developed world as I could to test the role of oxytocin on teamwork to convince myself that the neural signatures of cooperation were universal. (berkeley.edu)
  • This position backed up the idea that oxytocin may somehow play a role in the formation of these memories. (primal-page.com)
  • Oxytocin-deficient mice don't develop this familiarity despite showing normal discrimination of non-social stimuli such as fruit scents. (sfari.org)
  • Aging mice with extra oxytocin retained muscle mass that was lost by mice of similar age as their oxytocin naturally declined. (hplusmagazine.com)
  • Using samples from oxytocin knockout (KO) and wildtype (WT) mice, we find evidence of considerable interference in unextracted urine samples, with similar distributions of measured oxytocin in both genotypes. (biorxiv.org)
  • We present a new mixed-mode cation-exchange SPE method that minimizes interference-with knockout samples measuring below the assay's limit of detection-while effectively retaining oxytocin from the urine of wildtype mice. (biorxiv.org)
  • By identifying a new population of neurons activated by oxytocin, we have uncovered one way this chemical signal influences interactions between male and female mice," says Nathaniel Heintz, James and Marilyn Simons Professor and head of the Laboratory of Molecular Biology. (nutritionreview.org)
  • The interesting part is that when exposed to oxytocin these neurons fire more frequently in female mice than they do in male mice, possibly reflecting the differences that showed up in the behavioral tests. (nutritionreview.org)
  • We don't yet understand how, but we think oxytocin prompts mice in estrus to become interested in investigating their potential mates," Nakajima says. (nutritionreview.org)
  • Biochemically, you can't live on the 3-to-4-minute oxytocin boost that comes from a single act. (cedars-sinai.org)
  • Oxytocin can boost heart cells' ability to regenerate. (bigthink.com)