A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.
Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)
A nonapeptide that contains the ring of OXYTOCIN and the side chain of ARG-VASOPRESSIN with the latter determining the specific recognition of hormone receptors. Vasotocin is the non-mammalian vasopressin-like hormone or antidiuretic hormone regulating water and salt metabolism.
Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure.
Expulsion of milk from the mammary alveolar lumen, which is surrounded by a layer of milk-secreting EPITHELIAL CELLS and a network of myoepithelial cells. Contraction of the myoepithelial cells is regulated by neuroendocrine signals.
Hypothalamic nucleus overlying the beginning of the OPTIC TRACT.
Carrier proteins for OXYTOCIN and VASOPRESSIN. They are polypeptides of about 10-kDa, synthesized in the HYPOTHALAMUS. Neurophysin I is associated with oxytocin and neurophysin II is associated with vasopressin in their respective precursors and during transportation down the axons to the neurohypophysis (PITUITARY GLAND, POSTERIOR).
Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.
Contraction of the UTERINE MUSCLE.
The smooth muscle coat of the uterus, which forms the main mass of the organ.
A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
The repetitive uterine contraction during childbirth which is associated with the progressive dilation of the uterine cervix (CERVIX UTERI). Successful labor results in the expulsion of the FETUS and PLACENTA. Obstetric labor can be spontaneous or induced (LABOR, INDUCED).
A synthetic analog of vasopressin with ORNITHINE substitution at residue 8 of the cyclic nonapeptide. It is used as a local vasoconstrictor and hemostatic.
The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Nucleus in the anterior part of the HYPOTHALAMUS.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.
Artificially induced UTERINE CONTRACTION. Generally, LABOR, OBSTETRIC is induced with the intent to cause delivery of the fetus and termination of pregnancy.
The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.
The yellow body derived from the ruptured OVARIAN FOLLICLE after OVULATION. The process of corpus luteum formation, LUTEINIZATION, is regulated by LUTEINIZING HORMONE.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
Degradation of CORPUS LUTEUM. In the absence of pregnancy and diminishing trophic hormones, the corpus luteum undergoes luteolysis which is characterized by the involution and cessation of its endocrine function.
The behavior patterns associated with or characteristic of a mother.
The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.
In animals, the social relationship established between a male and female for reproduction. It may include raising of young.
Any behavior caused by or affecting another individual, usually of the same species.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete.
Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo.
Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than 500 ml or of the amount that adversely affects the maternal physiology, such as BLOOD PRESSURE and HEMATOCRIT. Postpartum hemorrhage is divided into two categories, immediate (within first 24 hours after birth) or delayed (after 24 hours postpartum).
(9 alpha,11 alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid (PGF(1 alpha)); (5Z,9 alpha,11,alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid (PGF(2 alpha)); (5Z,9 alpha,11 alpha,13E,15S,17Z)-9,11,15-trihydroxyprosta-5,13,17-trien-1-oic acid (PGF(3 alpha)). A family of prostaglandins that includes three of the six naturally occurring prostaglandins. All naturally occurring PGF have an alpha configuration at the 9-carbon position. They stimulate uterine and bronchial smooth muscle and are often used as oxytocics.
The final period of OBSTETRIC LABOR that is from the expulsion of the FETUS to the expulsion of the PLACENTA.
Failure of the UTERUS to contract with normal strength, duration, and intervals during childbirth (LABOR, OBSTETRIC). It is also called uterine atony.

Vasopressin stimulation of acetate incorporation into lipids in a dimethylbenz(a)anthracene-induced rat mammary tumor cell line. (1/1958)

In a preliminary report we described the effects of rat prolactin on the incorporation of [14C]acetate into lipids by a cell line from a dimethylbenz(a)anthracene-induced rat mammary tumor. The characteristics of the response to prolactin were very similar to those described for the normal rat mammary gland; namely, insulin was required for full expression of the response, maximal activity was not seen until 36 hr after the addition of the hormones, and growth hormone was able to elicit the same response. However, we were unable to detect binding of 125I-labeled prolactin to these cells, and furthermore, other more purified prolactin preparations were inactive. Upon further investigation we discovered that the activity resided in a low-molecular-weight fraction of the rat prolactin B-1 preparation and was probably either vasopressin or oxytocin or both. These data suggest the possibility that vasopressin may play a role in rodent mammary tumorigenesis.  (+info)

Central peptidergic neurons are hyperactive during collateral sprouting and inhibition of activity suppresses sprouting. (2/1958)

Little is known regarding the effect of chronic changes in neuronal activity on the extent of collateral sprouting by identified CNS neurons. We have investigated the relationship between activity and sprouting in oxytocin (OT) and vasopressin (VP) neurons of the hypothalamic magnocellular neurosecretory system (MNS). Uninjured MNS neurons undergo a robust collateral-sprouting response that restores the axon population of the neural lobe (NL) after a lesion of the contralateral MNS (). Simultaneously, lesioned rats develop chronic urinary hyperosmolality indicative of heightened neurosecretory activity. We therefore tested the hypothesis that sprouting MNS neurons are hyperactive by measuring changes in cell and nuclear diameters, OT and VP mRNA pools, and axonal cytochrome oxidase activity (COX). Each of these measures was significantly elevated during the period of most rapid axonal growth between 1 and 4 weeks after the lesion, confirming that both OT and VP neurons are hyperactive while undergoing collateral sprouting. In a second study the hypothesis that chronic inhibition of neuronal activity would interfere with the sprouting response was tested. Chronic hyponatremia (CH) was induced 3 d before the hypothalamic lesion and sustained for 4 weeks to suppress neurosecretory activity. CH abolished the lesion-induced increases in OT and VP mRNA pools and virtually eliminated measurable COX activity in MNS terminals. Counts of the total number of axon profiles in the NL revealed that CH also prevented axonal sprouting from occurring. These results are consistent with the hypothesis that increased neuronal activity is required for denervation-induced collateral sprouting to occur in the MNS.  (+info)

Production of prostaglandin f2alpha and its metabolite by endometrium and yolk sac placenta in late gestation in the tammar wallaby, Macropus Eugenii. (3/1958)

In this study, we investigated production of prostaglandin (PG) F2alpha and its metabolite, PGFM, by uterine tissues from tammar wallabies in late pregnancy. Endometrial explants were prepared from gravid and nongravid uteri of tammars between Day 18 of gestation (primitive streak) and Day 26.5 (term) and were incubated in Ham's F-10 medium supplemented with glutamine and antibiotics for 20 h. PGF2alpha and PGFM in the medium were assayed by specific, validated RIAs. Control tissues (leg muscle) did not produce detectable amounts of either PG. Both gravid and nongravid endometria secreted PGF2alpha, and production increased significantly in both gravid and nongravid uteri towards term. PGFM was produced in small amounts by both gravid and nongravid uteri, and the rate of production did not increase. Neither oxytocin nor dexamethasone stimulated PG production in vitro in any tissue at any stage. Thus, the surge in peripheral plasma PGFM levels seen at parturition may arise from increased uterine PG production, but further study is needed to define what triggers this release.  (+info)

Down-regulation of oxytocin-induced cyclooxygenase-2 and prostaglandin F synthase expression by interferon-tau in bovine endometrial cells. (4/1958)

Oxytocin (OT) is responsible for the episodic release of luteolytic prostaglandin (PG) F2alpha from the uterus in ruminants. The attenuation of OT-stimulated uterine PGF2alpha secretion by interferon-tau (IFN-tau) is essential for prevention of luteolysis during pregnancy in cows. To better understand the mechanisms involved, the effect of recombinant bovine IFN-tau (rbIFN-tau) on OT-induced PG production and cyclooxygenase-2 (COX-2) and PGF synthase (PGFS) expression in cultured endometrial epithelial cells was investigated. Cells were obtained from cows at Days 1-3 of the estrous cycle and cultured to confluence in RPMI medium supplemented with 5% steroid-free fetal calf serum. The cells were then incubated in the presence or absence of either 100 ng/ml OT or OT+100 ng/ml rbIFN-tau for 3, 6, 12, and 24 h. OT significantly increased PGF2alpha and PGE2 secretion at all time points (p < 0.01), while rbIFN-tau inhibited the OT-induced PG production and reduced OT receptor binding in a time-dependent manner. OT increased the steady-state level of COX-2 mRNA, measured by Northern blot, which was maximal at 3 h (9-fold increase) and then decreased with time (p < 0.01). OT also caused an increase in COX-2 protein, which peaked at 12 h (11-fold increase), as measured by Western blot. Addition of rbIFN-tau suppressed the induction of COX-2 mRNA (89%, p < 0.01) and COX-2 protein (50%, p < 0.01) by OT. OT also increased PGFS mRNA, and this stimulation was attenuated by rbIFN-tau (p < 0.01). To ensure that the decrease in COX-2 was not solely due to down-regulation of the OT receptor, cells were stimulated with a phorbol ester (phorbol 12-myristate 13-acetate; PMA) in the presence and absence of rbIFN-tau. The results showed that rbIFN-tau also decreased PMA-stimulated PG production and COX-2 protein. It can be concluded that rbIFN-tau inhibition of OT-stimulated PG production is due to down-regulation of OT receptor, COX-2, and PGFS.  (+info)

Oxytocin and vasopressin receptors in human and uterine myomas during menstrual cycle and early pregnancy. (5/1958)

The purpose of this study was to determine the specificity and concentration of oxytocin (OT) and arginine vasopressin (AVP) binding sites in non-pregnant (NP) human and rhesus monkey endometrium, myometrium and fibromyomas, and to determine the cellular localization of OT receptor (OTR). Besides [3H]AVP, [125I]LVA, a specific VP1 receptor subtype antagonist, was used to determine vasopressin receptor (VPR) concentrations. Samples were obtained from 42 pre-menopausal and three pregnant women (5, 13 and 35 weeks gestation), and several NP and pregnant monkeys. Specificity of binding was assessed in competition experiments with unlabelled agonists and antagonists of known pharmacological potency. Cellular localization of OTR was determined by immunohistochemistry. In NP human uterine tissues, [3H]AVP was bound with higher affinity and greater binding capacity than [3H]OT, whereas in pregnant women and in NP and pregnant rhesus monkeys, uterine OT binding capacity was greater. OT and AVP binding sites discriminated very poorly between OT and AVP; [125I]LVA binding sites were more selective than [3H]AVP. Their ligand specificity and binding kinetics indicated the presence of two distinct populations of binding sites for OT and AVP in primate uterus. Endometrium of NP women and monkeys had low OTR and VPR concentrations. Myometrial and endometrial OTR and VPR were down-regulated in midcycle and in early human pregnancy, they were up-regulated in the secretory phase and second half of pregnancy. Immunoreactive OTR in NP uterus was localized in patches of myometrial muscle cells and small numbers of endometrial epithelial cells.  (+info)

Desensitization of oxytocin receptors in human myometrium. (6/1958)

In the present study, we investigated the possible mechanisms by which oxytocin might regulate oxytocin receptor (OTR) density. Exposure of cultured myometrial cells to oxytocin for a prolonged period caused desensitization: the steady-state level of oxytocin binding was 210 x 10(3) binding sites/cell, but this was time-dependently reduced to 20.1 x 10(3) sites/cell by exposing the cells to oxytocin for up to 20 h. In contrast, Western blotting data showed that the total amount of OTR protein was not affected by oxytocin treatment for up to 24 h. Flow cytometry experiments demonstrated that OTRs were not internalized during this treatment. However, RNase protection assays and Northern analysis showed that in cultured myometrial cells OTR mRNA was reduced by oxytocin treatment to reach a new low steady-state concentration. Analysis of this mRNA in myometrial biopsies from 17 patients undergoing emergency Caesarean section showed how it decreased with advancing labour. Samples obtained after 12 h of labour contained approximately 50 times less OTR mRNA than samples obtained from patients in labour for less than 12 h. We speculate that this decrease in OTR mRNA represents in-vivo OTR desensitization.  (+info)

Uterine peristalsis during the follicular phase of the menstrual cycle: effects of oestrogen, antioestrogen and oxytocin. (7/1958)

Uterine peristalsis, directing sustained and rapid sperm transport from the external cervical os or the cervical crypts to the isthmic part of the tube ipsilateral to the dominant follicle, changes in direction and frequency during the menstrual cycle, with lowest activity during menstruation and highest activity at mid cycle. It was therefore suggested that uterine peristalsis is under the control of the dominant follicle with the additional involvement of oxytocin. To test this hypothesis, vaginal sonography of uterine peristalsis was performed in the early, mid and late proliferative phases, respectively, of cycles of women treated with oestradiol valerate and with human menopausal gonadotrophin following pituitary downregulation, with clomiphene citrate and with intravenous oxytocin, respectively. Administration of oestradiol valerate resulted in oestradiol serum concentrations comparable with the normal cycle with a simulation of the normal frequency of peristaltic contractions. Elevated oestradiol concentrations and bolus injections of oxytocin resulted in a significant increase in the frequency of peristaltic contractions in the early and mid follicular phases, respectively. Chlomiphene tended, though insignificantly so, to suppress the frequency of peristaltic waves in the presence of elevated oestradiol concentrations. In the late follicular phase of the cycle extremely elevated oestradiol concentrations as well as the injection of oxytocin resulted only in an insignificant further increase of peristaltic frequency. In the normal cycles, as well as during extremely elevated oestradiol concentrations and following oxytocin administration, the peristaltic contractions were always confined to the subendometrial layer of the muscular wall. The results and the review of literature indicate that uterine peristalsis during the follicular phase of the menstrual cycle is controlled by oestradiol released from the dominant follicle with the probable involvement of oxytocin, which is presumably stimulated together with its receptor within the endometrial-subendometrial unit and therefore acting in an autocrine/paracrine fashion. Since unphysiological stimulation with oestradiol and oxytocin did not significantly increase the frequency of uterine peristalsis in the late follicular phase of the cycle it is assumed that normal preovulatory frequency of uterine peristalsis is at a level which cannot be significantly surpassed due to phenomena of refractoriness of the system.  (+info)

Sperm transport in the human female genital tract and its modulation by oxytocin as assessed by hysterosalpingoscintigraphy, hysterotonography, electrohysterography and Doppler sonography. (8/1958)

The transport function of the uterus and oviducts and its modulation by oxytocin has been examined using hysterosalpingoscintigraphy, recording of intrauterine pressure, electrohysterography and Doppler sonography of the Fallopian tubes. After application to the posterior vaginal fornix, a rapid (within minutes) uptake of the labelled particles into the uterus was observed during the follicular and during the luteal phase of the cycle in all patients. Transport into the oviducts, however, could only be demonstrated during the follicular phase. Transport was directed predominantly into the tube ipsilateral to the ovary bearing the dominant follicle; the contralateral oviduct appeared to be functionally closed. The proportion of patients exhibiting ipsilateral transport did increase concomitant with the increase of the diameter of the dominant follicle. That ipsilateral transport has biological significance is suggested by the observation that the pregnancy rate following spontaneous intercourse or insemination was significantly higher in those women in whom ipsilateral transport could be demonstrated than in those who failed to exhibit lateralization. Oxytocin administration was followed by a dramatic increase in the amount of material transported to the ipsilateral tube, as demonstrated by radionuclide imaging and by Doppler sonography following instillation of ultrasound contrast medium. Continuous recording of intrauterine pressure before and after oxytocin administration did show an increase in basal tonus and amplitude of contractions and a reversal of the pressure gradient from a fundo-cervical to a cervico-fundal direction. These actions of oxytocin were accompanied by an increase in amplitude of potentials recorded by electrohysterography. These data support the view that uterus and Fallopian tubes represent a functional unit that is acting as a peristaltic pump and that the increasing activity of this pump during the follicular phase of the menstrual cycle is reflected by an increased transport into the oviduct ipsilateral to the ovary bearing the dominant follicle. In addition, they strongly suggest a critical role of oxytocin in this process. Failure of this mechanism appears to be a cause of subfertility or infertility, as indicated by the low pregnancy rate following intrauterine insemination or normal intercourse in the presence of patent Fallopian tubes. It may be regarded as a new nosological entity for which we propose the term tubal transport disorder (TTD). Since pregnancy rate of such patients is normal when treated with in-vitro fertilization (IVF), hysterosalpingoscintigraphy seems to be useful for the choice of treatment modalities in patients with patent Fallopian tubes suffering from infertility.  (+info)

Oxytocin is a hormone that is produced in the hypothalamus and released by the posterior pituitary gland. It plays a crucial role in various physiological processes, including social bonding, childbirth, and breastfeeding. During childbirth, oxytocin stimulates uterine contractions to facilitate labor and delivery. After giving birth, oxytocin continues to be released in large amounts during breastfeeding, promoting milk letdown and contributing to the development of the maternal-infant bond.

In social contexts, oxytocin has been referred to as the "love hormone" or "cuddle hormone," as it is involved in social bonding, trust, and attachment. It can be released during physical touch, such as hugging or cuddling, and may contribute to feelings of warmth and closeness between individuals.

In addition to its roles in childbirth, breastfeeding, and social bonding, oxytocin has been implicated in other physiological functions, including regulating blood pressure, reducing anxiety, and modulating pain perception.

Oxytocics are a class of medications that stimulate the contraction of uterine smooth muscle. They are primarily used in obstetrics to induce or augment labor, and to control bleeding after childbirth. Oxytocin is the most commonly used oxytocic and is naturally produced by the posterior pituitary gland. Synthetic forms of oxytocin, such as Pitocin, are often used in medical settings to induce labor or reduce postpartum bleeding. Other medications with oxytocic properties include ergometrine and methylergometrine. It's important to note that the use of oxytocics should be monitored carefully as overuse can lead to excessive uterine contractions, which may compromise fetal oxygenation and increase the risk of uterine rupture.

Vasotocin is not generally recognized as a medical term or a well-established physiological concept in human medicine. However, it is a term used in comparative endocrinology and animal physiology to refer to a nonapeptide hormone that is functionally and structurally similar to arginine vasopressin (AVP) or antidiuretic hormone (ADH) in mammals.

Vasotocin is found in various non-mammalian vertebrates, including fish, amphibians, and reptiles, where it plays roles in regulating water balance, blood pressure, social behaviors, and reproduction. In these animals, vasotocin is produced by the hypothalamus and stored in the posterior pituitary gland before being released into the circulation to exert its effects on target organs.

Therefore, while not a medical definition per se, vasotocin can be defined as a neuropeptide hormone that regulates various physiological functions in non-mammalian vertebrates, with structural and functional similarities to mammalian arginine vasopressin.

Vasopressin, also known as antidiuretic hormone (ADH), is a hormone that helps regulate water balance in the body. It is produced by the hypothalamus and stored in the posterior pituitary gland. When the body is dehydrated or experiencing low blood pressure, vasopressin is released into the bloodstream, where it causes the kidneys to decrease the amount of urine they produce and helps to constrict blood vessels, thereby increasing blood pressure. This helps to maintain adequate fluid volume in the body and ensure that vital organs receive an adequate supply of oxygen-rich blood. In addition to its role in water balance and blood pressure regulation, vasopressin also plays a role in social behaviors such as pair bonding and trust.

Medical definition: "Milk ejection," also known as the "let-down reflex," is the release of milk from the alveoli (milk-producing sacs) of the breast during breastfeeding or pumping. It occurs when the hormone oxytocin is released into the bloodstream, causing the smooth muscles surrounding the alveoli to contract and push out the milk. This reflex is an essential part of lactation and helps ensure that the baby receives enough milk during feeding. The milk ejection can be triggered by various stimuli such as suckling, thinking about or hearing the baby, or physical touch.

The supraoptic nucleus (SON) is a collection of neurons located in the hypothalamus, near the optic chiasm, in the brain. It plays a crucial role in regulating osmoregulation and fluid balance within the body through the production and release of vasopressin, also known as antidiuretic hormone (ADH).

Vasopressin is released into the bloodstream and acts on the kidneys to promote water reabsorption, thereby helping to maintain normal blood pressure and osmolarity. The supraoptic nucleus receives input from osmoreceptors in the circumventricular organs of the brain, which detect changes in the concentration of solutes in the extracellular fluid. When the osmolarity increases, such as during dehydration, the supraoptic nucleus is activated to release vasopressin and help restore normal fluid balance.

Additionally, the supraoptic nucleus also contains oxytocin-producing neurons, which play a role in social bonding, maternal behavior, and childbirth. Oxytocin is released into the bloodstream and acts on various tissues, including the uterus and mammary glands, to promote contraction and milk ejection.

Neurophysins are small protein molecules that are derived from the larger precursor protein, pro-neurophysin. They are synthesized in the hypothalamus of the brain and are stored in and released from neurosecretory granules, along with neurohypophysial hormones such as oxytocin and vasopressin.

Neurophysins serve as carrier proteins for these hormones, helping to stabilize them and facilitate their transport and release into the bloodstream. There are two main types of neurophysins, neurophysin I and neurophysin II, which are associated with oxytocin and vasopressin, respectively.

Neurophysins have been studied for their potential role in various physiological processes, including water balance, social behavior, and reproductive functions. However, their precise mechanisms of action and functional significance are still not fully understood.

The posterior pituitary gland, also known as the neurohypophysis, is the posterior portion of the pituitary gland. It is primarily composed of nerve fibers that originate from the hypothalamus, a region of the brain. These nerve fibers release two important hormones: oxytocin and vasopressin (also known as antidiuretic hormone or ADH).

Oxytocin plays a role in social bonding, sexual reproduction, and childbirth. During childbirth, it stimulates uterine contractions to help facilitate delivery, and after birth, it helps to trigger the release of milk from the mother's breasts during breastfeeding.

Vasopressin, on the other hand, helps regulate water balance in the body by controlling the amount of water that is excreted by the kidneys. It does this by increasing the reabsorption of water in the collecting ducts of the kidney, which leads to a more concentrated urine and helps prevent dehydration.

Overall, the posterior pituitary gland plays a critical role in maintaining fluid balance, social bonding, and reproduction.

A uterine contraction is a rhythmic, involuntary muscle tightening that occurs in the uterus. These contractions are primarily caused by the activation of smooth muscle cells within the uterine wall, known as myometrial cells. They play a crucial role in various reproductive processes, including menstruation, implantation of a fertilized egg, and childbirth (labor).

During labor, strong and frequent uterine contractions help to dilate the cervix and efface (thin) the lower part of the uterus. As the contractions become more intense and regular, they assist in moving the baby down through the birth canal, ultimately resulting in delivery. Uterine contractions are regulated by a complex interplay of hormones, neurotransmitters, and other signaling molecules, ensuring proper coordination and timing throughout the reproductive process.

The myometrium is the middle and thickest layer of the uterine wall, composed mainly of smooth muscle cells. It is responsible for the strong contractions during labor and can also contribute to bleeding during menstruation or childbirth. The myometrium is able to stretch and expand to accommodate a growing fetus and then contract during labor to help push the baby out. It also plays a role in maintaining the structure and shape of the uterus, and in protecting the internal organs within the pelvic cavity.

Dinoprost is a synthetic form of prostaglandin F2α, which is a naturally occurring hormone-like substance in the body. It is used in veterinary medicine as a uterotonic agent to induce labor and abortion in various animals such as cows and pigs. In human medicine, it may be used off-label for similar purposes, but its use must be under the close supervision of a healthcare provider due to potential side effects and risks.

It is important to note that Dinoprost is not approved by the FDA for use in humans, and its availability may vary depending on the country or region. Always consult with a licensed healthcare professional before using any medication, including Dinoprost.

'Labor, Obstetric' refers to the physiological process that occurs during childbirth, leading to the expulsion of the fetus from the uterus. It is divided into three stages:

1. The first stage begins with the onset of regular contractions and cervical dilation and effacement (thinning and shortening) until full dilation is reached (approximately 10 cm). This stage can last from hours to days, particularly in nulliparous women (those who have not given birth before).
2. The second stage starts with complete cervical dilation and ends with the delivery of the baby. During this stage, the mother experiences strong contractions that help push the fetus down the birth canal. This stage typically lasts from 20 minutes to two hours but can take longer in some cases.
3. The third stage involves the delivery of the placenta (afterbirth) and membranes, which usually occurs within 15-30 minutes after the baby's birth. However, it can sometimes take up to an hour for the placenta to be expelled completely.

Obstetric labor is a complex process that requires careful monitoring and management by healthcare professionals to ensure the safety and well-being of both the mother and the baby.

Ornipressin is not a commonly used medication in modern clinical practice, and it's possible that you may be referring to desmopressin, which is an analog of the natural hormone vasopressin. Here is the definition for desmopressin:

Desmopressin: A synthetic analog of the natural hormone arginine vasopressin, used as a nasal spray, injection, or tablet to treat diabetes insipidus (a condition in which the kidneys can't regulate the body's water balance) and von Willebrand disease (a genetic disorder that affects blood clotting). It works by decreasing the amount of urine produced by the kidneys, increasing the concentration of certain substances in the urine, and helping the blood to clot. Desmopressin is also used off-label for the treatment of nocturnal enuresis (bedwetting) in children.

The uterus, also known as the womb, is a hollow, muscular organ located in the female pelvic cavity, between the bladder and the rectum. It has a thick, middle layer called the myometrium, which is composed of smooth muscle tissue, and an inner lining called the endometrium, which provides a nurturing environment for the fertilized egg to develop into a fetus during pregnancy.

The uterus is where the baby grows and develops until it is ready for birth through the cervix, which is the lower, narrow part of the uterus that opens into the vagina. The uterus plays a critical role in the menstrual cycle as well, by shedding its lining each month if pregnancy does not occur.

Pregnancy is a physiological state or condition where a fertilized egg (zygote) successfully implants and grows in the uterus of a woman, leading to the development of an embryo and finally a fetus. This process typically spans approximately 40 weeks, divided into three trimesters, and culminates in childbirth. Throughout this period, numerous hormonal and physical changes occur to support the growing offspring, including uterine enlargement, breast development, and various maternal adaptations to ensure the fetus's optimal growth and well-being.

The Paraventricular Hypothalamic Nucleus (PVN) is a nucleus in the hypothalamus, which is a part of the brain that regulates various autonomic functions and homeostatic processes. The PVN plays a crucial role in the regulation of neuroendocrine and autonomic responses to stress, as well as the control of fluid and electrolyte balance, cardiovascular function, and energy balance.

The PVN is composed of several subdivisions, including the magnocellular and parvocellular divisions. The magnocellular neurons produce and release two neuropeptides, oxytocin and vasopressin (also known as antidiuretic hormone), into the circulation via the posterior pituitary gland. These neuropeptides play important roles in social behavior, reproduction, and fluid balance.

The parvocellular neurons, on the other hand, project to various brain regions and the pituitary gland, where they release neurotransmitters and neuropeptides that regulate the hypothalamic-pituitary-adrenal (HPA) axis, which is responsible for the stress response. The PVN also contains neurons that produce corticotropin-releasing hormone (CRH), a key neurotransmitter involved in the regulation of the HPA axis and the stress response.

Overall, the Paraventricular Hypothalamic Nucleus is an essential component of the brain's regulatory systems that help maintain homeostasis and respond to stressors. Dysfunction of the PVN has been implicated in various pathological conditions, including hypertension, obesity, and mood disorders.

Progesterone is a steroid hormone that is primarily produced in the ovaries during the menstrual cycle and in pregnancy. It plays an essential role in preparing the uterus for implantation of a fertilized egg and maintaining the early stages of pregnancy. Progesterone works to thicken the lining of the uterus, creating a nurturing environment for the developing embryo.

During the menstrual cycle, progesterone is produced by the corpus luteum, a temporary structure formed in the ovary after an egg has been released from a follicle during ovulation. If pregnancy does not occur, the levels of progesterone will decrease, leading to the shedding of the uterine lining and menstruation.

In addition to its reproductive functions, progesterone also has various other effects on the body, such as helping to regulate the immune system, supporting bone health, and potentially influencing mood and cognition. Progesterone can be administered medically in the form of oral pills, intramuscular injections, or vaginal suppositories for various purposes, including hormone replacement therapy, contraception, and managing certain gynecological conditions.

Lactation is the process by which milk is produced and secreted from the mammary glands of female mammals, including humans, for the nourishment of their young. This physiological function is initiated during pregnancy and continues until it is deliberately stopped or weaned off. The primary purpose of lactation is to provide essential nutrients, antibodies, and other bioactive components that support the growth, development, and immune system of newborns and infants.

The process of lactation involves several hormonal and physiological changes in a woman's body. During pregnancy, the hormones estrogen and progesterone stimulate the growth and development of the mammary glands. After childbirth, the levels of these hormones drop significantly, allowing another hormone called prolactin to take over. Prolactin is responsible for triggering the production of milk in the alveoli, which are tiny sacs within the breast tissue.

Another hormone, oxytocin, plays a crucial role in the release or "let-down" of milk from the alveoli to the nipple during lactation. This reflex is initiated by suckling or thinking about the baby, which sends signals to the brain to release oxytocin. The released oxytocin then binds to receptors in the mammary glands, causing the smooth muscles around the alveoli to contract and push out the milk through the ducts and into the nipple.

Lactation is a complex and highly regulated process that ensures the optimal growth and development of newborns and infants. It provides not only essential nutrients but also various bioactive components, such as immunoglobulins, enzymes, and growth factors, which protect the infant from infections and support their immune system.

In summary, lactation is the physiological process by which milk is produced and secreted from the mammary glands of female mammals for the nourishment of their young. It involves hormonal changes, including the actions of prolactin, oxytocin, estrogen, and progesterone, to regulate the production, storage, and release of milk.

Induced labor refers to the initiation of labor before it begins spontaneously, which is usually achieved through medical intervention. This process is initiated when there is a medically indicated reason to deliver the baby, such as maternal or fetal compromise, prolonged pregnancy, or reduced fetal movement. The most common methods used to induce labor include membrane stripping, prostaglandin administration, and oxytocin infusion. It's important to note that induced labor carries certain risks, including a higher chance of uterine hyperstimulation, infection, and the need for assisted vaginal delivery or cesarean section. Therefore, it should only be performed under the close supervision of a healthcare provider in a clinical setting.

Estrus is a term used in veterinary medicine to describe the physiological and behavioral state of female mammals that are ready to mate and conceive. It refers to the period of time when the female's reproductive system is most receptive to fertilization.

During estrus, the female's ovaries release one or more mature eggs (ovulation) into the fallopian tubes, where they can be fertilized by sperm from a male. This phase of the estrous cycle is often accompanied by changes in behavior and physical appearance, such as increased vocalization, restlessness, and swelling of the genital area.

The duration and frequency of estrus vary widely among different species of mammals. In some animals, such as dogs and cats, estrus occurs regularly at intervals of several weeks or months, while in others, such as cows and mares, it may only occur once or twice a year.

It's important to note that the term "estrus" is not used to describe human reproductive physiology. In humans, the equivalent phase of the menstrual cycle is called ovulation.

The corpus luteum is a temporary endocrine structure that forms in the ovary after an oocyte (egg) has been released from a follicle during ovulation. It's formed by the remaining cells of the ruptured follicle, which transform into large, hormone-secreting cells.

The primary function of the corpus luteum is to produce progesterone and, to a lesser extent, estrogen during the menstrual cycle or pregnancy. Progesterone plays a crucial role in preparing the uterus for potential implantation of a fertilized egg and maintaining the early stages of pregnancy. If pregnancy does not occur, the corpus luteum will typically degenerate and stop producing hormones after approximately 10-14 days, leading to menstruation.

However, if pregnancy occurs, the developing embryo starts to produce human chorionic gonadotropin (hCG), which signals the corpus luteum to continue secreting progesterone and estrogen until the placenta takes over hormonal production, usually around the end of the first trimester.

The hypothalamus is a small, vital region of the brain that lies just below the thalamus and forms part of the limbic system. It plays a crucial role in many important functions including:

1. Regulation of body temperature, hunger, thirst, fatigue, sleep, and circadian rhythms.
2. Production and regulation of hormones through its connection with the pituitary gland (the hypophysis). It controls the release of various hormones by producing releasing and inhibiting factors that regulate the anterior pituitary's function.
3. Emotional responses, behavior, and memory formation through its connections with the limbic system structures like the amygdala and hippocampus.
4. Autonomic nervous system regulation, which controls involuntary physiological functions such as heart rate, blood pressure, and digestion.
5. Regulation of the immune system by interacting with the autonomic nervous system.

Damage to the hypothalamus can lead to various disorders like diabetes insipidus, growth hormone deficiency, altered temperature regulation, sleep disturbances, and emotional or behavioral changes.

Luteolysis is the physiological process that leads to the breakdown and regression of the corpus luteum, a temporary endocrine structure in the ovary that forms after ovulation. The corpus luteum produces progesterone, which supports pregnancy in mammals. If pregnancy does not occur, luteolysis takes place approximately 10-14 days after ovulation in humans and is characterized by the degeneration of the corpus luteum, decreased production of progesterone, and the initiation of the menstrual cycle or the onset of a new reproductive cycle.

The primary event that triggers luteolysis is the release of prostaglandin F2α (PGF2α) from the uterus, which reaches the corpus luteum through the systemic circulation and causes vasoconstriction, reduced blood flow, and structural damage to the corpus luteum. This results in a decline in progesterone levels, which ultimately leads to menstruation or the onset of a new reproductive cycle.

In summary, luteolysis is a crucial process in the female reproductive system that regulates hormonal balance and prepares the body for a new reproductive cycle when pregnancy does not occur.

Maternal behavior refers to the nurturing and protective behaviors exhibited by a female animal towards its offspring. In humans, this term is often used to describe the natural instincts and actions of a woman during pregnancy, childbirth, and early child-rearing. It encompasses a broad range of activities such as feeding, grooming, protecting, and teaching the young.

In the context of medical and psychological research, maternal behavior is often studied to understand the factors that influence its development, expression, and outcomes for both the mother and offspring. Factors that can affect maternal behavior include hormonal changes during pregnancy and childbirth, as well as social, cultural, and environmental influences.

Abnormal or atypical maternal behavior may indicate underlying mental health issues, such as postpartum depression or anxiety, and can have negative consequences for both the mother and the child's development and well-being. Therefore, it is important to monitor and support healthy maternal behaviors in new mothers to promote positive outcomes for both parties.

"Animal pregnancy" is not a term that is typically used in medical definitions. However, in biological terms, animal pregnancy refers to the condition where a fertilized egg (or eggs) implants and develops inside the reproductive tract of a female animal, leading to the birth of offspring (live young).

The specific details of animal pregnancy can vary widely between different species, with some animals exhibiting phenomena such as placental development, gestation periods, and hormonal changes that are similar to human pregnancy, while others may have very different reproductive strategies.

It's worth noting that the study of animal pregnancy and reproduction is an important area of biological research, as it can provide insights into fundamental mechanisms of embryonic development, genetics, and evolution.

A pair bond, in the context of human and animal behavior, refers to a long-term emotional and social attachment between two individuals, usually characterized by a strong affection, shared activities, and often sexual interaction. In humans, this concept is often discussed in the context of romantic relationships and marriage. From a medical or scientific perspective, pair bonding involves neurological and hormonal processes that help to create and maintain the attachment, such as the release of oxytocin and vasopressin during physical touch and sexual activity. The strength and duration of pair bonds can vary widely between different species and individuals.

Social behavior, in the context of medicine and psychology, refers to the ways in which individuals interact and engage with others within their social environment. It involves various actions, communications, and responses that are influenced by cultural norms, personal values, emotional states, and cognitive processes. These behaviors can include but are not limited to communication, cooperation, competition, empathy, altruism, aggression, and conformity.

Abnormalities in social behavior may indicate underlying mental health conditions such as autism spectrum disorder, schizophrenia, or personality disorders. Therefore, understanding and analyzing social behavior is an essential aspect of diagnosing and treating various psychological and psychiatric conditions.

I apologize, but "sheep" is not a term that has a medical definition. It is a common animal with the scientific name Ovis aries. If you have any medical or health-related questions, I would be happy to try and help answer those for you.

Tocolytic agents are a type of medication used in obstetrics to suppress premature labor. They work by relaxing the smooth muscle of the uterus, thereby reducing contractions and delaying delivery. Commonly used tocolytic agents include beta-adrenergic agonists (such as terbutaline), calcium channel blockers (such as nifedipine), and prostaglandin synthesis inhibitors (such as indomethacin). It's important to note that the use of tocolytic agents is typically reserved for specific clinical situations, and their benefits must be weighed against potential risks to both the mother and fetus.

Hormone antagonists are substances or drugs that block the action of hormones by binding to their receptors without activating them, thereby preventing the hormones from exerting their effects. They can be classified into two types: receptor antagonists and enzyme inhibitors. Receptor antagonists bind directly to hormone receptors and prevent the hormone from binding, while enzyme inhibitors block the production or breakdown of hormones by inhibiting specific enzymes involved in their metabolism. Hormone antagonists are used in the treatment of various medical conditions, such as cancer, hormonal disorders, and cardiovascular diseases.

Lypressin is a synthetic analogue of a natural hormone called vasopressin, which is produced by the pituitary gland in the brain. The primary function of vasopressin, also known as antidiuretic hormone (ADH), is to regulate water balance in the body by controlling the amount of urine produced by the kidneys.

Lypressin has similar physiological effects to vasopressin and is used in medical treatments for conditions related to the regulation of water balance, such as diabetes insipidus. Diabetes insipidus is a condition characterized by excessive thirst and the production of large amounts of dilute urine due to a deficiency in vasopressin or an impaired response to it.

In summary, Lypressin is a synthetic form of vasopressin, a hormone that helps regulate water balance in the body by controlling urine production in the kidneys. It is used as a therapeutic agent for treating diabetes insipidus and related conditions.

The endometrium is the innermost layer of the uterus, which lines the uterine cavity and has a critical role in the menstrual cycle and pregnancy. It is composed of glands and blood vessels that undergo cyclic changes under the influence of hormones, primarily estrogen and progesterone. During the menstrual cycle, the endometrium thickens in preparation for a potential pregnancy. If fertilization does not occur, it will break down and be shed, resulting in menstruation. In contrast, if implantation takes place, the endometrium provides essential nutrients to support the developing embryo and placenta throughout pregnancy.

Postpartum hemorrhage (PPH) is a significant obstetrical complication defined as the loss of more than 500 milliliters of blood within the first 24 hours after childbirth, whether it occurs vaginally or through cesarean section. It can also be defined as a blood loss of more than 1000 mL in relation to the amount of blood lost during the procedure and the patient's baseline hematocrit level.

Postpartum hemorrhage is classified into two types: primary (early) PPH, which occurs within the first 24 hours after delivery, and secondary (late) PPH, which happens between 24 hours and 12 weeks postpartum. The most common causes of PPH are uterine atony, trauma to the genital tract, retained placental tissue, and coagulopathy.

Uterine atony is the inability of the uterus to contract effectively after delivery, leading to excessive bleeding. Trauma to the genital tract can occur during childbirth, causing lacerations or tears that may result in bleeding. Retained placental tissue refers to the remnants of the placenta left inside the uterus, which can cause infection and heavy bleeding. Coagulopathy is a condition where the blood has difficulty clotting, leading to uncontrolled bleeding.

Symptoms of PPH include excessive vaginal bleeding, low blood pressure, increased heart rate, decreased urine output, and signs of shock such as confusion, rapid breathing, and pale skin. Treatment for PPH includes uterotonics, manual removal of retained placental tissue, repair of genital tract lacerations, blood transfusions, and surgery if necessary.

Preventing PPH involves proper antenatal care, monitoring high-risk pregnancies, active management of the third stage of labor, and prompt recognition and treatment of any bleeding complications during or after delivery.

Prostaglandin F (PGF) is a type of prostaglandin, which is a group of lipid compounds that are synthesized in the body from fatty acids and have diverse hormone-like effects. Prostaglandin F is a naturally occurring compound that is produced in various tissues throughout the body, including the uterus, lungs, and kidneys.

There are two major types of prostaglandin F: PGF1α and PGF2α. These compounds play important roles in a variety of physiological processes, including:

* Uterine contraction: Prostaglandin F helps to stimulate uterine contractions during labor and childbirth. It is also involved in the shedding of the uterine lining during menstruation.
* Bronchodilation: In the lungs, prostaglandin F can help to relax bronchial smooth muscle and promote bronchodilation.
* Renal function: Prostaglandin F helps to regulate blood flow and fluid balance in the kidneys.

Prostaglandin F is also used as a medication to induce labor, treat postpartum hemorrhage, and manage some types of glaucoma. It is available in various forms, including injections, tablets, and eye drops.

The third stage of labor is the period between the delivery of the baby and the expulsion of the placenta. It is also known as the afterbirth stage. This stage is typically completed within 5-30 minutes, but can take up to an hour. During this stage, the uterus continues to contract, causing the separation of the placenta from the uterine wall. Once separated, the placenta is expelled from the body with the help of contractions and a strong push from the mother. It is important for medical professionals to monitor this stage closely to ensure that the entire placenta is expelled and to manage any potential complications, such as heavy bleeding.

Uterine inertia is a medical condition that occurs during childbirth, specifically during the second stage of labor. It is defined as the failure of the uterus to contract efficiently and effectively during this stage, leading to prolonged or arrested labor. This can result in complications for both the mother and the baby, such as fetal distress, postpartum hemorrhage, and infection. Uterine inertia can be caused by various factors, including exhaustion of the uterus, drugs that interfere with muscle contractions, or abnormalities in the uterus itself. Treatment typically involves administering oxytocin to stimulate stronger contractions, assisted delivery methods such as forceps or vacuum extraction, or in some cases, cesarean section.

... has a molecular mass of 1007 Da, and one international unit (IU) of oxytocin is the equivalent of 1.68 μg of pure ... "Oxytocin" is the name of the fifth song on Billie Eilish's second album Happier Than Ever. Oxytocin is mentioned in the first ... Oxytocin is believed to have a significant role in social learning. There are indicators that oxytocin may help to decrease ... Secretion of oxytocin from the neurosecretory nerve endings is regulated by the electrical activity of the oxytocin cells in ...
... agonists have also been developed. Peptide Carbetocin Demoxytocin Lipo-oxytocin-1 Merotocin Oxytocin Non- ... The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of ... Wikimedia Commons has media related to Oxytocin receptors. Oxytocin+receptor at the U.S. National Library of Medicine Medical ... Several selective ligands for the oxytocin receptor have recently been developed, but close similarity between the oxytocin and ...
One IU of oxytocin is the equivalent of about 2 μg or mcg of pure peptide. Injection: Clinical doses of oxytocin are given by ... Oxytocin's milk ejection property was described by Ott and Scott in 1910 and by Schafer and Mackenzie in 1911. Oxytocin was the ... Synthetic oxytocin, sold under the brand name Pitocin among others, is a medication made from the peptide oxytocin. As a ... Buccal: Oxytocin was delivered in buccal tablets, but this is not common practice any more. Under the tongue: Oxytocin is ...
"Oxytocin" as an EDM song: The Ringer Source labling "Oxytocin" as an electronica song: ABC News Sources labling "Oxytocin" as ... "Oxytocin" as the 86th best song of 2021 according to the website's readers. "Oxytocin" was released as the fifth track on ... "Oxytocin" received widespread acclaim from music critics praising its production, sentiment and vocal delivery. "Oxytocin" ... "Oxytocin" has been called the 20th best song by Billie Eilish by Far Out Magazine's Tyler Golsen, stating it is the "perfect ...
... (LOT-1) is a synthetic peptide and derivative of oxytocin that acts as an agonist of the oxytocin receptor. The ... After adjusting for molecular weight (LOT-1 is ~1.5x the weight of oxytocin), oxytocin and LOT-1 are equipotent. In addition, ... "Lipo-oxytocin-1, a Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-Lasting Effects on Anxiety-Related ... It has yet to be determined whether LOT-1 possesses improved blood-brain-barrier permeability relative to oxytocin. Carbetocin ...
An oxytocin receptor agonist is a compound that acts as an agonist of the oxytocin receptor. Examples include peptide oxytocin ... Oxytocin receptor agonists are used medically to induce labor, promote lactation, and for other uses. In addition, oxytocin ... Small-molecule oxytocin receptor agonists are considered to be more promising for such uses due to better pharmacokinetic ... v t e v t e (Oxytocin receptor agonists, All stub articles, Genito-urinary system drug stubs, Nervous system drug stubs). ...
... Oxytocin (OT) has potential to be a treatment for Postpartum Depression (PPD)[1]. ... This method is often the preferred method[4]. Oxytocin (OT) is a neuropeptide that can be administered in this manner. IN ... A review of 38 randomized and controlled trials suggests that short-term use of intranasal oxytocin appears to have few side- ... Short-term use of intranasal oxytocin (OT) appears to be equally safe in vulnerable individuals as well as those deemed healthy ...
In 2019, a large review of the effects of oxytocin found that the oxytocin level in fathers that engage in SSC is increased as ... Oxytocin is further released during labour when the fetus stimulates the cervix and vagina, and it is believed that it plays a ... Oxytocin is the most common method used to increase the rate of vaginal delivery. The World Health Organization recommends its ... The act of nursing a child also causes a release of oxytocin to help the baby get milk more easily from the nipple. Station ...
"Oxytocin, Carbetocin". IOCB Prague. Retrieved 2022-08-05. "Guaiazulene". IOCB Prague. Retrieved 2022-08-05. Dějiny Ústavu ... the development of first method for industrial production of human neurohypophysial hormone oxytocin by Josef Rudinger, ...
Co-author) Bainbridge M. H.; Nixon W. C.; Schild H. O. (19 May 1956). "Synthetic Oxytocin". British Medical Journal. 1 (4976): ...
... oxytocin; VSP: vasopressin; NP: Neuropeptides; KOR, MOR, DOR: kappa-, mu- and delta-opioid receptors correspondingly; sANS - ...
Oxytocin/Copycat 12. Ilomilo 13. Your Power 14. Bellyache/Ocean Eyes 15. Getting Older 16. Lost Cause 17. When the Party's Over ...
Furthermore, the oxytocin levels of the couples correlate positively; when the oxytocin secretion of one increases, the other ... As the level of oxytocin increases so does sexual motivation. While oxytocin plays a major role in parent child relationships, ... while lower levels of oxytocin reduce motivation for these activities.[citation needed] Research on oxytocin's role in the ... Oxytocin plays a similar role in non-human primates as it does in humans. Grooming, sex, and cuddling frequencies correlate ...
Oxytocin and coitus. Sexual and Relationship Therapy (1988);3:29-36 Carter CS. Oxytocin and sexual behavior. Neuroscience & ... Oxytocin has been suggested as critical to the thoughts and behaviors required to maintain close relationships.[verification ... Prolactin and oxytocin are responsible for inducing milk production in women. Follicle-stimulating hormone (FSH) is responsible ... Sexual intimacy and orgasms increase levels of oxytocin, which helps people bond and build trust. A long-term study of 3,500 ...
Oxytocin Oxytocin is one of the most commonly used medications for cervical effacement. It is given as an infusion to either ... Oxytocin dysregulation has been linked to Autism or autism spectrum disorder. As oxytocin is one of the methods used for ... Oxytocin may also be used in the setting of amniotomy as well as balloon catheters to further contractions in conjunction to ... "Oxytocin Drug Information". UpToDate. Retrieved 2023-07-27. Triglia MT, Palamara F, Lojacono A, Prefumo F, Frusca T (2010). "A ...
Lee, Heon-Jin; Macbeth, Abbe H.; Pagani, Jerome; Young, Walter Scott III (June 2009). "Oxytocin: the great facilitator of life ... Riley, Alan J. (1988). "Oxytocin and coitus". Sexual and Marital Therapy. 3 (1): 29-36. doi:10.1080/02674658808407690. ISSN ... Carter, C. Sue (1992). "Oxytocin and sexual behavior". Neuroscience & Biobehavioral Reviews. 16 (2): 131-144. doi:10.1016/s0149 ... increases levels of the hormone oxytocin, also known as "the love hormone", which helps people bond and build trust. Sexual ...
The hormones oxytocin and vasopressin are implicated in regulating both male and female sexual motivation. Oxytocin is released ... Based on the pleasure model of sexual motivation, the increased sexual pleasure that occurs following oxytocin release may ... Emotional closeness can be an especially strong predictor of sexual motivation in females and insufficient oxytocin release may ... Keverne E. B.; Curley J. P. (2004). "Vasopressin, oxytocin and social behaviour". Neurobiology. 14 (6): 777-783. doi:10.1016/j. ...
"Oxytocin intranasal - Vyera Pharmaceuticals". AdisInsight. Retrieved 24 September 2017. Mullin, Emily (February 27, 2015). " ... Syntocinon, short for 'synthetic oxytocin', was first introduced by the Swiss pharmaceutical company Sandoz in 1956. The ... "Retrophin Signs U.S. License Agreement for Syntocinon™ Nasal Spray (Oxytocin)". Business Wire. December 12, 2013. Retrieved 19 ... This product, also called TUR-001, is Turing Pharmaceuticals' oxytocin nasal solution. ...
"Oxytocin and social norms reduce xenophobia". University of Bonn. 12 August 2017. Retrieved 5 May 2019. "Raus aus der ... "Oxytocin and social norms reduce xenophobia". University of Bonn. 12 August 2017. Retrieved 5 January 2019. Michelle Castillo ( ... Scheele, D. (2012). "Oxytocin Modulates Social Distance between Males and Females". The Journal of Neuroscience. 32 (46): 16074 ... The same year, Hurlemann published research showing that oxytocin combined with a prominent social norm, could lead to ...
... is a non-peptide partial agonist of the oxytocin and vasopressin V2 receptors (Ki = 147 nM and >1000 nM, respectively ... "Non-peptide oxytocin agonists". Bioorganic & Medicinal Chemistry Letters. 14 (17): 4585-4589. doi:10.1016/j.bmcl.2004.04.107. ... Oxytocin receptor agonists, Vasopressin receptor agonists, Vasopressin receptor antagonists, Thioamides, All stub articles, ...
I.D. Neumann, R.K. Liedtke, M. Ludwig, R. Langraf: Intranasally applied Oxytocin: Brain uptake and effects on neuronal ... Annual Meeting 2000, Melbourne R. K. Liedtke, R. Landgraf, I. D. Neumann, Intranasally applied Oxytocin: A novel route of ... Antidepressive effect of oxytocin. This has been predicted with a new biocybernetics model (1998/99), hereafter these effects ...
Neurophysins are binding proteins, of which there are two types: neurophysin I and neurophysin II, which bind to oxytocin and ... Antidiuretic hormone (ADH) and oxytocin are both stored in Herring bodies, but are not stored simultaneously in the same ... Fibers from supraoptic nuclei are concerned with ADH secretion; paraventricular nuclei with oxytocin. This anatomical structure ...
... stimulates production and release of further oxytocin. For example, when oxytocin is released during a contraction of the ... Oxytocin is produced by the body naturally and since the 1950s has also been available in synthetic pharmaceutical form. In ... du Vigneaud V, Ressler C, Swan JM, Roberts CW, Katsoyannis PG (June 1954). "The synthesis of oxytocin". J. Am. Chem. Soc. 76 ( ... These are Braxton Hicks contractions, which are sometimes referred to as "false labour." The hormone oxytocin has been ...
Greg Miller (2010), The prickly side of oxytocin, Science, 328, 1343 De Dreu, C.K.W., Greer, L.L., Van Kleef, G.A., Shalvi, S ... Using behavioral game theory and neuroscience methods, he showed how the hypothalamic neuropeptide oxytocin modelates self- ... "The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans." Science, 328, 1408 - 1411. Prof. ... Handgraaf, M.J.J. (2011). Oxytocin promotes human ethnocentrism. Proceedings of the National Academy of Sciences USA, 108, 1262 ...
Oxytocin is associated with behaviors involving contact with the child. Increases in oxytocin following high contact ... Oxytocin has been shown to correlate with many aspects of paternal care, but its mechanisms and the systems involved are not ... Oxytocin's interactions with other hormones is thought to be responsible for creating variability in parent behaviors such as ... An increase in levels of oxytocin, glucocorticoids, estrogen and prolactin occur in the paternal brain. These hormonal changes ...
The peptide hormones oxytocin and vasopressin were isolated and their total syntheses first reported in 1954. It is not ... Vincent du Vigneaud was awarded the 1955 Nobel Prize in Chemistry for the total synthesis of the natural polypeptide oxytocin ... du Vigneaud V, Ressler C, Swan JM, Roberts CW, Katsoyannis PG (1954). "The Synthesis of Oxytocin". Journal of the American ...
"Trust, morality -- and oxytocin?". Archived from the original on 2012-06-01. Retrieved 2017-06-14. Anderson C, Kraus MW, ... Sasaki JY, Kim HS, Xu J (2011-11-01). "Religion and Well-being The Moderating Role of Culture and the Oxytocin Receptor (OXTR) ... Neuroeconomist Paul Zak studies morality, oxytocin, and trust, among other variables. Based on research findings, Zak ...
He also carried out a series of structure-activity relationships for oxytocin and vasopressin, perhaps the first of their type ... Even before his Nobel-Prize-winning work on elucidating and synthesizing oxytocin and vasopressin via manipulating the AVP gene ... Du Vigneaud, V. (1956). "Trail of sulfur research: from insulin to oxytocin". Science. 123 (3205): 967-974. Bibcode:1956Sci... ... a reference to his work on the peptide hormone oxytocin. Vincent du Vigneaud was born in Chicago in 1901, the son of French ...
Algoe, Sara B.; Kurtz, Laura E.; Grewen, Karen (2017-10-02). "Oxytocin and Social Bonds: The Role of Oxytocin in Perceptions of ... Oxytocin has also been found to play many roles in the bonding between mother and child. In addition to pair-bonding and ... Thus oxytocin may play a flexible role in relationship maintenance, supporting both the feelings that bring us closer and the ... In mammals, oxytocin has been found to be released during childbirth, breastfeeding, sexual stimulation, bonding, and in some ...
"Chemical trust: oxytocin oxymoron?" Am. J. Bioethics 5 (2005): 1. Henry, Rick; Tyler, Anthony O.; Coyne-DeGhett, Stephanie; ...
Oxytocin has a molecular mass of 1007 Da, and one international unit (IU) of oxytocin is the equivalent of 1.68 μg of pure ... "Oxytocin" is the name of the fifth song on Billie Eilishs second album Happier Than Ever. Oxytocin is mentioned in the first ... Oxytocin is believed to have a significant role in social learning. There are indicators that oxytocin may help to decrease ... Secretion of oxytocin from the neurosecretory nerve endings is regulated by the electrical activity of the oxytocin cells in ...
More than 15 years ago Edward Stricker and Joseph Verbalis reported that oxytocin (OT) is involved in the neural control of ... We think that oxytocin might normally act in the brain to inhibit intake only in certain types of feeding or drinking ... Tags: Anorexia, Baby, Brain, Dehydration, Digestion, Food, Genetic Engineering, Genomics, Hormone, Medicine, Oxytocin, Peptides ... "Oxytocin and ingestive behavior." Linda Rinaman, University of Pittsburgh. NIH grant. Rinaman is participating in the symposium ...
Trust Drug Oxytocin Unbelievable For Now. Researchers balk at media reports hyping the effects of the love drug hormone. ... A Google search reveals at least two proprietary formulation nasal sprays containing oxytocin. One spray, OxyCalm, is touted as ... She hoped the oxytocin spray would help her overcome her fear of socializing. ... the phone calls have been less about his research and more about media reports that have elevated the status of the oxytocin ...
... large-scale study shows that oxytocin -- a naturally occurring substance produced in the brain and throughout the body -- ... Oxytocin improves brain function in children with autism. Date:. May 19, 2012. Source:. Yale University. Summary:. Preliminary ... "Oxytocin improves brain function in children with autism." ScienceDaily. www.sciencedaily.com. /. releases. /. 2012. /. 05. /. ... 13, 2021 Oxytocin, a naturally occurring hormone that acts as a chemical messenger in the brain, showed no evidence of helping ...
... and a hug can release incredible amounts of Oxytocin, or the feel-good hormone. Combine a pillow and a hug, and youve got the ... Scientifically speaking, a soft pillow can be relaxing… and a hug can release incredible amounts of Oxytocin, or the feel-good ... mimicking an embrace and helping fight stress and nervousness by boosting the release of endorphins and oxytocin to make you ...
People give more when under the influence of oxytocin. ... Oxytocin: The Holiday Hormone. New study: People give more when ... A recent study in the journal Hormones and Behavior suggests that the presence of oxytocin-a chemical released by the body ... Weve reported many times on the effects of oxytocin, which has been found to increase feelings of group affiliation and trust ... But this is the first study to show that oxytocin can cause people to become more generous even when the object of their ...
Sales and business experts have always talked about the power of a handshake to make a good first impression and start building a relationship. Researchers at the University of Iowa showed that to be the case when they found that job ...
Cuddle Chemical Oxytocin Relieves Alcohol Withdrawal. Oxytocin is best known for its role in creating social bonds, but it may ... The oxytocin itself isnt rewarding: it is simply connecting the reward with the memory of the person and the relationship. In ... Increasing oxytocin levels, therefore, might cue the reward system to react the way it does in the presence of the drug, ... And oxytocin was found to help dramatically. Those given the hormone required nearly five times less lorazepam to get through ...
... oxytocin detection system. They werent expecting what happened next. ... Prairie voles can find partners just fine without the love hormone oxytocin. The hormone was thought to be essential to how ... Now, a study suggests that the "love hormone" once thought essential for their bonding - oxytocin - might not be so necessary ... The molecule oxytocin has long been thought to be important in this process. ...
An accumulating body of evidence suggests that the hypothalamic neuropeptide oxytocin (OT) has a modulatory effect on pain ... Oxytocin and Pain Perception: From Animal Models to Human Research Neuroscience. 2018 Sep 1:387:149-161. doi: 10.1016/j. ... An accumulating body of evidence suggests that the hypothalamic neuropeptide oxytocin (OT) has a modulatory effect on pain ...
51 patients had additional IV administration of 40 IU of oxytocin in 5% Glucose or 0,9% NaCl solution during therapy ... after application of oxytocin.,i, Methods,/i,. 156 women with symptomatic uterine fibroids were treated using MR-guided HIFU ... Oxytocin administration seems to improve efficiency of HIFU therapy although further research is required to assess its value. ... Nonperfused volume was statistically significantly larger in oxytocin group than in control group (p=0.0019). The remaining ...
The neuropeptide oxytocin (OT) is associated with a plethora of social behaviors and is a key topic at the intersection of ... The precursor ions for native oxytocin and IS were m/z 1007.475 and m/z 1012.475, respectively. For oxytocin the product ions ... The formation of oxytocin dimers is suppressed by the zinc-aspartate-oxytocin complex. Journal of pharmaceutical sciences 102, ... Oxytocin (OT) acetate salt hydrate (≥97%), oxytocin-d5 (98%, internal standard (IS)), dithiothreitol (DTT), iodoacetamide (IAM ...
Some view the hormone oxytocin as a panacea for aiding labor and delivery, lactation, maternal bonding, sexual ... New research, however, suggests that oxytocin must be used carefully because too much oxytocin (in healthy young adults) can ... Too Much Oxytocin in Ordinary Adults May Lead to Emotional Problems. Medically reviewed by Scientific Advisory Board - By Rick ... As a result, some doctors prescribe oxytocin off-label, to treat mild social unease in patients who dont suffer from a ...
Researchers reveal that the hormone oxytocin appears to increase social behaviors in newborn rhesus monkeys. ... Lower cortisol levels after oxytocin exposure indicate that oxytocin may also function to diminish anxiety, the researchers ... After exposure to oxytocin, the strong imitators were more likely to look at caregivers and stand close to them than they were ... Oxytocin, a hormone produced by the pituitary gland, is involved in labor, birth and breast milk production. Studies have also ...
Read stories, features and news related to oxytocin. ... What is oxytocin: unraveling the love hormone by Tibi Puiu. ... No oxytocin required - Love hormone might not be the magic bullet that we thought it to be by Fermin Koop ... Oxytocin is not a viable treatment for children and teenagers with autism, after all by Alexandru Micu ... The love hormone, oxytocin, was found to neutralize the motor deficiency effects of alcohol in rats, sobering them up. The ... ...
The oxytocin receptor is essential for the hormone oxytocin to exert its effects and the gene can determine how many are ... Oxytocin is an extremely important hormone, involved in social interaction and bonding in mammals, including humans. Its well ... It is well known that oxytocin is actively involved in early social, perceptual, and cognitive processes, and, that it ... The children with higher methylation levels at 18-months, and presumably lower levels of oxytocin receptor, were also more ...
The hormone oxytocin is important for social interaction and to control emotions. A deficiency of this hormone has previously ... from the University of Basel and the University Hospital of Basel have succeeded in demonstrating a deficiency of oxytocin in ... Oxytocin boosters only work on the healthy. Oxytocin is, however, difficult to measure and a "stimulation test" is needed to ... Therapy with oxytocin?. "These results therefore prove for the first time that a clinically relevant oxytocin deficiency ...
... we have shown that oxytocin levels significantly increased in both plasma and CSF. However, whereas oxytocin plasma ... Here using combined blood and cerebrospinal fluid (CSF) sampling in subjects receiving either 24 IU of oxytocin (n = 11) or ... Moreover, there was no correlation (r = <0.10) between oxytocin plasma and CSF concentrations. Together, these data provide ... There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and ...
Garret Stuber and colleagues used in vivo calcium imaging to show that a population of oxytocin-positive (OT) neurons in the ... Paraventricular oxytocin neurons support social behavior on SFARI ... Oxytocin is known to play a role in myriad social behaviors in ... A new study shows that a population of oxytocin-positive (OT) neurons in the paraventricular nucleus of the hypothalamus (PVH) ... Acute, systemic treatment with an oxytocin receptor agonist, WAY267464, restored social preference in Shank3b KO mice. ...
Oxytocin signaling pathway - Homo sapiens (human) [ Pathway menu , Organism menu , Pathway entry , Show description , Download ... Oxytocin also influences cardiovascular regulation and various social behaviors. The actions of OT are all mediated by one type ... Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular ( ...
Is an alternative oxytocin use to support pregnancy? ... Oxytocin Use to Support Pregnancy?. *Vitrification of Larger ... Oxytocin Use to Support Pregnancy Instead of Regumate (Altrenogest)?. It seems initially counter-intuitive to consider oxytocin ... The question then is can oxytocin treatment during early pregnancy have the same effect and can one use oxytocin instead of ... The hypothesis for this effect is that the exogenous oxytocin inhibits the natural increase in endometrial oxytocin receptor ...
Ipamorelin Oxytocin Sermorelin Hexarelin Gonadorelin HGH 176-191 TB500 (Thymosin beta 4).... ...
Risk. Risk of environmental impact of oxytocin cannot be excluded, due to the lack of environmental toxicity data. ... Environmental information is missing on fass.se for oxytocin (2023-06-28). It is voluntary for manufacturers to provide ... Toxicity. It cannot be excluded that oxytocin is toxic, due to the lack of data. ... Bioaccumulation. It cannot be excluded that oxytocin bioaccumulates, due to the lack of data. ...
Browse Oxytocin news, research and analysis from The Conversation ... Oxytocin may benefit some children with autism, but its not ... The study investigated what role oxytocin had in memory. De Visu/ Shutterstock July 27, 2020 Could love hormone oxytocin help ... Articles on Oxytocin. Displaying 1 - 20 of 26 articles. Zuzha/Shutterstock September 28, 2023 Face pareidolia: how pregnant ... Poor knowledge and practice around oxytocin could put women in Nigeria at risk during childbirth. Chioma S. Ejekam, University ...
The Metabolic-Psychosomatic Axis, Stress and Oxytocin Regulation. $240.00. Alfred Bennun, Ph.D.. Full Professor-Emeritus- ... the Fight-or-flight Response in the Hypothalamus Signals for a Multi-hormonal Adaptive Response Shifting Levels of Oxytocin, ...
Central endogenous opioid inhibition of supraoptic oxytocin neurons in pregnant rats. AJ Douglas, I Neumann, HK Meeren, G Leng ... Release of oxytocin within the SON, measured by microdialysis in conscious rats, was also increased by naloxone in late ... Central endogenous opioid inhibition of supraoptic oxytocin neurons in pregnant rats. AJ Douglas, I Neumann, HK Meeren, G Leng ... Central endogenous opioid inhibition of supraoptic oxytocin neurons in pregnant rats. AJ Douglas, I Neumann, HK Meeren, G Leng ...
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Posts matching tags oxytocin. 2011/1/18. New research has shown that oxytocin, the neurochemical which promotes feelings of ... The stronger the signal of trust, the more oxytocin increases. In addition, the more oxytocin increases, the more trustworthy ( ... oxytocin could also be useful as a non-lethal mass-behaviour-control weapon. Imagine oxytocin bombs dropped on Afghanistan, ... via bOING bOING) ¶ better living through chemistry influence manipulation nonlethal weapons oxytocin trust 0 ...
Oxytocin : Review : Talk about feeling short-changed; what starts off a righteous, albeit derivative romp across the desert- ... Harms Way - _Oxytocin_. (Black Lodge, 2006). by: Jackie Smit (5 out of 10) ... The trouble is that by the time the record hits the halfway mark, _Oxytocin_ has long run dry of surprises, and even a sped-up ...
... the microhouse was born Empat aka Oxytocin was… ... Empat aka Oxytocin was born and raised in Bucharest in the mid ... Oxytocin being one of those alliases. The musical style approached can be very different from track to track, looking to have a ...
  • Zak, a professor of economics and the founding director of the Center for Neuroeconomics Studies at Claremont Graduate University in Claremont, Calif., is generally happy to talk about his research, which focuses on the effect of the hormone oxytocin on mood and emotion. (go.com)
  • The "love hormone" oxytocin can relieve symptoms of withdrawal in people recovering from alcoholism, according to a small new study. (time.com)
  • Some view the hormone oxytocin as a panacea for aiding labor and delivery, lactation, maternal bonding, sexual satisfaction, social recognition, and anxiety. (psychcentral.com)
  • Researchers at the National Institutes of Health, the University of Parma, Italy, and the University of Massachusetts Amherst reveal that the hormone oxytocin appears to increase social behaviors in newborn rhesus monkeys. (medindia.net)
  • The love hormone, oxytocin, was found to neutralize the motor deficiency effects of alcohol in rats, sobering them up. (zmescience.com)
  • The oxytocin receptor is essential for the hormone oxytocin to exert its effects and the gene can determine how many are produced,' explains Kathleen Krol, a Hartwell postdoctoral fellow in Connelly's Lab at the University of Virginia who conducted the study together with Tobias Grossmann at MPI CBS in Leipzig. (mpg.de)
  • The hormone oxytocin is important for social interaction and to control emotions. (unibas.ch)
  • Could 'love hormone' oxytocin help treat Alzheimer's disease? (theconversation.com)
  • Kerstin, also known as the "mother of oxytocin" is the world's leading expert and researcher on the powerful hormone oxytocin. (natalhypnotherapy.co.uk)
  • However, oxytocin neurons make other peptides, including corticotropin-releasing hormone (CRH) and dynorphin, for example, that act locally. (wikipedia.org)
  • The magnocellular neurons that make oxytocin are adjacent to magnocellular neurons that make vasopressin, and are similar in many respects. (wikipedia.org)
  • Because the production of the two hormones is so close anatomically, disorders that cause vasopressin deficiency could also affect the neurons that produce oxytocin," explains Dr. Cihan Atila, endocrinologist and lead author of a study that has now been published in the journal Lancet Diabetes and Endocrinology . (unibas.ch)
  • A new study shows that a population of oxytocin-positive (OT) neurons in the paraventricular nucleus of the hypothalamus (PVH) responds preferentially to social stimuli and is necessary for social behavior. (sfari.org)
  • The figure shows activity heat maps (left and middle panels) and total time spent in each zone (right panel) in the three-chamber test in mice expressing a Gi-coupled DREADD in oxytocin-positive neurons in the paraventricular nucleus of the hypothalamus (PVH-OT), following administration of the DREADD ligand clozapine- N -Oxide (CNO) or saline. (sfari.org)
  • Social stimuli induce activation of oxytocin neurons within the paraventricular nucleus of the hypothalamus to promote social behavior in male mice. (sfari.org)
  • Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. (genome.jp)
  • In anesthetized rats the firing rate of SON neurons was recorded and oxytocin neurons identified by an excitatory response to intravenous cholecystokinin. (jneurosci.org)
  • We conclude that in late pregnancy, after day 16, endogenous opioids inhibit oxytocin neurons either directly, on their cell bodies, or presynaptically on inputs. (jneurosci.org)
  • Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets. (iasp-pain.org)
  • Using a combination of optical, behavioral and genetic approaches in the larval zebrafish, we describe a novel role for hypothalamic oxytocin (OXT) neurons in the processing of noxious stimuli. (iasp-pain.org)
  • Now, a study suggests that the "love hormone" once thought essential for their bonding - oxytocin - might not be so necessary after all. (sciencenews.org)
  • Discover how the enigmatic oxytocin, known as the love hormone, shapes human bonds. (zmescience.com)
  • Oxytocin, also known as the "love hormone" or the "trust hormone," frequently makes its way into the news in connection to the latest studies on topics ranging from fidelity to morality to hugs. (smithsonianmag.com)
  • Amazing things happen in your body once you give birth - including the release of oxytocin, also known as the Love Hormone. (medela.us)
  • Oxytocin , sometimes dubbed " the love hormone ," can be tricky to study in humans. (stanford.edu)
  • Our findings provide the first, critical steps toward devising more effective treatments for the core social deficits in autism, which may involve a combination of clinical interventions with an administration of oxytocin," said Gordon. (sciencedaily.com)
  • 2012. Effect of Administration of Oxytocin During Diestrus on Corpus Luteum Function and Endometrial Oxytocin Receptor Concentration in Cycling Mares. (equine-reproduction.com)
  • What are the evidence-based guidelines regarding the administration of oxytocin for labour induction and augmentation? (cadth.ca)
  • Two non-randomized studies were identified regarding the clinical effectiveness of oxytocin administration with the use of a safety checklist for labour induction and augmentation.Four evidence-based guidelines were identified regarding the administration of oxytocin for labour induction and augmentation. (cadth.ca)
  • We conclude that long-term 3V administration of oxytocin to rats can both prevent and treat diet-induced obesity. (nih.gov)
  • An accumulating body of evidence suggests that the hypothalamic neuropeptide oxytocin (OT) has a modulatory effect on pain processing. (nih.gov)
  • The neuropeptide oxytocin (OT) is associated with a plethora of social behaviors and is a key topic at the intersection of psychology and biology. (nature.com)
  • The neuropeptide oxytocin (OXT) has recently emerged as playing a key role in human social cognition and behaviour. (nature.com)
  • We were interested in exploring whether the involvement of the mother, in the original play session, would have an influence on the oxytocin receptor gene of the child, a year later. (mpg.de)
  • If mothers were particularly involved in the game with their children, there was a greater reduction in DNA methylation of the oxytocin receptor gene one year later. (mpg.de)
  • Decreased DNA methylation in this region has previously been associated with increased expression of the oxytocin receptor gene. (mpg.de)
  • Research studies surveying behavioral associations with SNPs in the Oxytocin Receptor Gene (OXTR) have found links to emotional regulation, behaviors, personality traits, and socially-related diagnoses (1). (salimetrics.com)
  • 2014). Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills. (salimetrics.com)
  • 2011). Oxytocin receptor gene (OXTR) is related to psychological resources. (salimetrics.com)
  • The oxytocin receptor gene (OXTR) has been studied in autism because of the role of oxytocin (OT) in social cognition. (rti.org)
  • [ 4 ] We are discovering that long-lasting changes in the oxytocin receptor gene are induced by the birth process itself, by maternal behavior, and by being exposed to exogenous oxytocin. (medscape.com)
  • Researchers at the University of Basel and the University Hospital of Basel, led by Professor Mirjam Christ-Crain, have now shown that oxytocin levels are 8.5 times higher in healthy individuals after a single dose of MDMA, while they remain unchanged in those with vasopressin deficiency. (unibas.ch)
  • Here using combined blood and cerebrospinal fluid (CSF) sampling in subjects receiving either 24 IU of oxytocin (n = 11) or placebo (n = 4) we have shown that oxytocin levels significantly increased in both plasma and CSF. (nature.com)
  • Production and secretion of oxytocin is controlled by a positive feedback mechanism, where its initial release stimulates production and release of further oxytocin. (wikipedia.org)
  • Estrogen has been found to increase the secretion of oxytocin and to increase the expression of its receptor, the oxytocin receptor, in the brain. (wikipedia.org)
  • This test stimulates oxytocin secretion, i.e. the release of the hormone in the body. (unibas.ch)
  • The hypothesis for this effect is that the exogenous oxytocin inhibits the natural increase in endometrial oxytocin receptor concentration at the end of diestrus that normally leads to oxytocin-induced PGF2α secretion, which in turn would result in luteolysis [1] . (equine-reproduction.com)
  • Naloxone increases oxytocin secretion in pregnant rats, suggesting restraint by endogenous opioids but we have previously reported that oxytocin nerve terminals in the neural lobe become desensitized to opioid actions in late pregnancy. (jneurosci.org)
  • Thus, the opioids restrain premature oxytocin secretion until parturition when there is a high demand for it. (jneurosci.org)
  • It's well known that a new mother's oxytocin levels can influence her behavior and as a result, the bond she makes with her baby. (mpg.de)
  • However, in this study we ask whether the mother's behavior might also have a decisive influence on the development of the baby's oxytocin system itself. (mpg.de)
  • Physical contact also increases a mother's oxytocin levels, which can help breastmilk flow. (cdc.gov)
  • This creates a potentially dangerous scenario since there have been no studies on the long-term consequences of taking oxytocin. (smithsonianmag.com)
  • Preliminary results from an ongoing, large-scale study shows that oxytocin -- a naturally occurring substance produced in the brain and throughout the body -- increased brain function in regions that are known to process social information in children and adolescents with autism spectrum disorders (ASD). (sciencedaily.com)
  • Mar. 7, 2019 Oxytocin has been the focus of intense research around autism spectrum disorder (ASD) due to the hormone's reported positive effects on anxiety, empathy, social interaction, and maternal behavior. (sciencedaily.com)
  • Because of this, many researchers have suggested that oxytocin might be useful in treating conditions affecting social behavior such as autism spectrum disorders. (medindia.net)
  • Meyer, the UMass Amherst neuroscientist, calls the findings "exciting" because they not only support the idea that oxytocin may have a positive effect on social interaction among children on the autism spectrum, but because the newborn monkeys provide an informative, generalizable model for studying early neurobiology and social behavior during development. (medindia.net)
  • The annual meeting of the American College of Neuropsychopharmacology has been told that oxytocin may have significant positive effects on adult autism patients. (scienceagogo.com)
  • The study examined the effects of oxytocin - sometimes referred to as the trust drug - on repetitive behaviors and aspects of social cognition in adults with autism. (scienceagogo.com)
  • Researcher Eric Hollander, from the Mt. Sinai School of Medicine, believes that autism could be a good candidate for treatment with oxytocin as it presents with the types of symptoms that have been found to be associated with oxytocin. (scienceagogo.com)
  • In the study, adults with autism or Asperger's disorder received an intravenous infusion of pitocin (synthetic oxytocin) or placebo (saline solution) over a four-hour period. (scienceagogo.com)
  • The researchers also looked at the effects of oxytocin on social cognition (autism patients are often unable to detect or read emotion in others through facial and voice cues). (scienceagogo.com)
  • Hollander and his colleagues are among the first to have used both intravenous and nasal delivery to study the behavioral effects of oxytocin in autism spectrum disorders. (scienceagogo.com)
  • 2008). Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. (salimetrics.com)
  • And though the science lags behind, Yong writes, hyped coverage of the hormone spurs parents into rushing out to buy oxytocin nasal spray for their children with autism or depression. (smithsonianmag.com)
  • Parker's team is now conducting studies of possible therapeutic uses of oxytocin in children with autism. (stanford.edu)
  • instead, oxytocin levels in kids with autism fall across a broad range. (stanford.edu)
  • The findings hint at a future in which patients' oxytocin levels could be used to guide treatment for autism or other psychiatric or developmental disorders. (stanford.edu)
  • Oxytocin has recently received attention for its involvement in regulating social abilities because of its role in many aspects of social behavior and social cognition in humans and other species. (sciencedaily.com)
  • A recent study in the journal Hormones and Behavior suggests that the presence of oxytocin-a chemical released by the body during positive social interactions, like exchanging gifts-may cause people already prone to giving to give even more. (berkeley.edu)
  • A new epigenetic study by Kathleen Krol and Jessica Connelly from the University of Virginia and Tobias Grossmann from the Max Planck Institute for Human Cognitive and Brain Sciences now suggests that mothers' or fathers' behavior can also have a substantial impact on their children's developing oxytocin systems. (mpg.de)
  • As expected, the increase in oxytocin in the healthy individuals after a dose of MDMA caused pro-social behavior and an increase in empathy, combined with a reduction in anxiety symptoms. (unibas.ch)
  • Initial levels of oxytocin at the first trimester predicted bonding behavior. (science20.com)
  • Researchers say that a form of oxytocin - the hormone correlated with human love - has a similar effect on fish, suggesting it is a key regulator of social behavior that has evolved and endured since ancient times. (science20.com)
  • Oxytocin had already been called the "hormone of mother love" by people studying maternal behavior in animals and humans. (medscape.com)
  • Oxytocin is a hormone of the posterior pituitary that promotes lactation, maternal bonding, and birth. (frontiersin.org)
  • But lately, the phone calls have been less about his research and more about media reports that have elevated the status of the oxytocin nasal spray his team devised to that of a truth serum, a trust drug -- even a love potion. (go.com)
  • A Google search reveals at least two proprietary formulation nasal sprays containing oxytocin. (go.com)
  • The team members gave the children a single dose of oxytocin in a nasal spray and used functional magnetic resonance brain imaging to observe its effect. (sciencedaily.com)
  • Oxytocin itself is not addictive: most people given a nasal spray containing the hormone cannot distinguish it from placebo, although about 1/3 of men get erections and people do become more trusting and cooperative in some settings. (time.com)
  • To arrive at this conclusion, the researchers administered either an oxytocin nasal spray or a placebo to healthy, straight men. (smithsonianmag.com)
  • Oxytocin and vasopressin are the only known hormones released by the human posterior pituitary gland to act at a distance. (wikipedia.org)
  • Meyer's assay core laboratory is expert in measuring not only oxytocin and cortisol concentrations, but several other hormones in a variety of sample types including hair, blood, saliva and cerebrospinal fluid. (medindia.net)
  • The hormones oxytocin and vasopressin are produced in the same area of the brain and are also very similar in structure. (unibas.ch)
  • We learned that providing a safe and comfortable birthing environment along with birth support, such as a doula, encourages the release of a woman's love hormones, like oxytocin, which naturally enables her body to labor and birth. (orgasmicbirth.com)
  • One of the most notable birth signaling hormones is oxytocin , which is administered to roughly 50% of laboring women in the United States prior to / during delivery. (bvsalud.org)
  • If a delivery system (perhaps an aerosolised form of oxytocin, or one that can be dissolved in drinking water) could be developed, oxytocin could also be useful as a non-lethal mass-behaviour-control weapon . (null.org)
  • To assess the impact of oxytocin on the brain function, Gordon and her team conducted a first-of-its-kind, double-blind, placebo-controlled study on children and adolescents aged 7 to 18 with ASD. (sciencedaily.com)
  • Risk of environmental impact of oxytocin cannot be excluded, due to the lack of environmental toxicity data. (janusinfo.se)
  • But this is the first study to show that oxytocin can cause people to become more generous even when the object of their kindness is distant and only indirectly connected to them: Participants who received oxytocin didn't know precisely when, where, or for whom their donations would be put to use, but they gave more anyway. (berkeley.edu)
  • The findings also show that oxytocin is related to the mental, as well as the behavioral, aspect of bonding. (science20.com)
  • A consensus panel of LAC experts was convened to quantify the expected increase in oxytocin rates as a consequence of making Uniject available. (bvsalud.org)
  • The same researchers at the Department of Clinical Research are currently planning a large study to investigate whether treatment with oxytocin can improve the psychological symptoms in patients with vasopressin deficiency. (unibas.ch)
  • Environmental information is missing on fass.se for oxytocin (2023-06-28). (janusinfo.se)
  • 2023. Effect of mid-diestrus oxytocin treatment on early pregnancy in the mare. (equine-reproduction.com)
  • Earlier research in adults has shown that oxytocin increases certain social behaviors, says behavioral endocrinologist Jerrold Meyer of UMass Amherst, but the current study is the first to show that it may have the same effect in primate infants, including humans. (medindia.net)
  • There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and behaviour, however as yet no study has actually demonstrated that this modality of administration increases concentrations of the peptide in the brain as well as blood in humans. (nature.com)
  • mefloquine increases toxicity of oxytocin by QTc interval. (medscape.com)
  • misoprostol increases effects of oxytocin by pharmacodynamic synergism. (medscape.com)
  • oxytocin increases effects of dexfenfluramine by pharmacodynamic synergism. (medscape.com)
  • oxytocin increases effects of dexmethylphenidate by pharmacodynamic synergism. (medscape.com)
  • oxytocin increases effects of isoproterenol by pharmacodynamic synergism. (medscape.com)
  • Even if countries can achieve only small increases in oxytocin rates by incorporating Uniject, this strategy could be considered a highly efficient use of resources. (bvsalud.org)
  • In either form, oxytocin stimulates uterine contractions to speed up the process of childbirth. (wikipedia.org)
  • Oxytocin causes uterine contractions and will expel the pregnancy, right? (equine-reproduction.com)
  • Nor-binaltorphimine, a specific kappa- opioid antagonist, did not increase Fos or affect oxytocin release within the SON in any group. (jneurosci.org)
  • How much do one's acculturated expectations of touch affect oxytocin levels? (gordsellar.com)
  • It's not yet clear but some research suggests that oxytocin essentially "wires" your lover or child to your reward system, so that it is activated and you feel good when the person is present- and not so good when he or she is not there or you fear the loss of the relationship. (time.com)
  • New research, however, suggests that oxytocin must be used carefully because too much oxytocin (in healthy young adults) can actually result in oversensitivity to the emotions of others. (psychcentral.com)
  • This study, which appears in the November issue of Psychological Science, a journal of the Association for Psychological Science, suggests that women with higher levels of oxytocin during their first trimester are primed to the formation of an exclusive bond with their infants. (science20.com)
  • This study helps scientifically validate the use of measuring oxytocin in the blood, and suggests that oxytocin may be a biomarker of anxiety. (stanford.edu)
  • Based largely on a number of short-term administration studies, growing evidence suggests that central oxytocin is important in the regulation of energy balance. (nih.gov)
  • For example, when oxytocin is released during a contraction of the uterus at the start of childbirth, this stimulates production and release of more oxytocin and an increase in the intensity and frequency of contractions. (wikipedia.org)
  • Oxytocin is derived by enzymatic splitting from the peptide precursor encoded by the human OXT gene. (wikipedia.org)
  • The oxytocin peptide is synthesized as an inactive precursor protein from the OXT gene. (wikipedia.org)
  • Emerging and exciting areas of research and novel methodological approaches, including genome-wide gene expression studies, immune, endocannabinoid, oxytocin, and glutamatergic systems, are explored to help delineate innovative mechanisms that may contribute to resilience. (cdc.gov)
  • A team of researchers, led by Jorge Barraza of Claremont Graduate University's Center for Neuroeconomics Studies, gave 132 male college students a dose of either oxytocin or a placebo. (berkeley.edu)
  • In a within-subjects study with infant rhesus monkeys, where the infants served as their own controls interacting with a human caregiver while inhaling oxytocin and without it, the NIH researchers found that oxytocin increased two facial gestures associated with social interactions. (medindia.net)
  • By observing the monkeys' ability to imitate the two gestures, the researchers sought to determine if oxytocin could promote social interaction through a gesture that was natural to them as well as through a gesture not part of their normal communication sequence. (medindia.net)
  • Now, for the first time, researchers from the University of Basel and the University Hospital of Basel have succeeded in demonstrating a deficiency of oxytocin in patients with a deficiency of vasopressin caused by a disease of the pituitary gland. (unibas.ch)
  • After the mothers completed an extensive survey and an interview on their bond-related thoughts, feelings, and behaviors, the researchers computed the link between levels of oxytocin and bonding. (science20.com)
  • For the experiments, researchers injected the cichlids with either isotocin, a "fish version" of oxytocin - or a control saline solution. (science20.com)
  • Measuring blood oxytocin is much easier, but some researchers have questioned whether blood oxytocin levels truly reflect what's happening in the brain. (stanford.edu)
  • Our results are the first evidence that [oxytocin] may block alcohol withdrawal symptoms in humans," the authors write. (time.com)
  • Oxytocin is an extremely important hormone, involved in social interaction and bonding in mammals, including humans. (mpg.de)
  • These findings implicate oxytocin in the bonding process, but little research has been done on this relationship in humans. (science20.com)
  • 2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. (salimetrics.com)
  • A new Stanford study simplifies the problem: It is the first research in children, and some of the first in any age group of humans, to indicate that blood and CSF oxytocin levels track together. (stanford.edu)
  • The research also found a correlation between low-oxytocin and high-anxiety levels in children, adding to findings from animal studies and adult humans that have documented this oxytocin-anxiety link. (stanford.edu)
  • His lab conducted the chemical analyses of oxytocin and cortisol in the infant monkeys' saliva for this NIH study, quantifying how much of the hormone got into the animals' systems via inhalation. (medindia.net)
  • In women, a single dose of estradiol has been found to be sufficient to increase circulating oxytocin concentrations. (wikipedia.org)
  • By chance, sodium ascorbate by itself was found to stimulate the production of oxytocin from ovarian tissue over a range of concentrations in a dose-dependent manner. (wikipedia.org)
  • Many of the same tissues (e.g. ovaries, testes, eyes, adrenals, placenta, thymus, pancreas) where PAM (and oxytocin by default) is found are also known to store higher concentrations of vitamin C. Oxytocin is known to be metabolized by the oxytocinase, leucyl/cystinyl aminopeptidase. (wikipedia.org)
  • However, whereas oxytocin plasma concentrations peaked at 15 min after intranasal administration and decreased after 75 min, CSF concentrations took up to 75 min to reach a significant level. (nature.com)
  • 0.10) between oxytocin plasma and CSF concentrations. (nature.com)
  • We found that participants who had high concentrations of salivary oxytocin tended to feel strong ownership of the rubber hand. (frontiersin.org)
  • First author Elizabeth Simpson of the NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development says, "It was important to test whether oxytocin would promote social behaviors in infants in the same respects as it appears to promote social interaction among adults. (medindia.net)
  • It is well known that oxytocin is actively involved in early social, perceptual, and cognitive processes, and, that it influences complex social behaviors,' says Tobias Grossmann. (mpg.de)
  • Oxytocin is known to play a role in myriad social behaviors in many species, but the neural circuits that mediate the effects of oxytocin are not well understood. (sfari.org)
  • Oxytocin also influences cardiovascular regulation and various social behaviors. (genome.jp)
  • Oxytocin (OXT) and arginine-vasopressin (AVP) are two phylogenetically conserved neuropeptides that have been implicated in a wide range of social behaviors. (frontiersin.org)
  • Additionally, mothers who had higher levels of oxytocin across the pregnancy and the postpartum month also reported more behaviors that support the formation of an exclusive relationship (i.e. singing a special song to the infant, or bathing and feeding them in a special way). (science20.com)
  • Oxytocin seems to be preparing mothers to engage in bonding behaviors. (science20.com)
  • Past] studies with animals have found that oxytocin plays a role in a variety of behaviors, including parent-child and adult-to-adult pair bonding, social memory, social cognition, anxiety reduction and repetitive behaviors," said co-researcher Jennifer Bartz, also from the Mt. Sinai School of Medicine. (scienceagogo.com)
  • Hollander noted a rapid reduction of repetitive behaviors over the course of the oxytocin infusion, whereas no such reduction occurred following the placebo infusion. (scienceagogo.com)
  • Oxytocin (OXT) is a neuropeptide known to play a pivotal role in the regulation of social cognition as well as in emotional behaviors such as anxiety and depression. (lu.se)
  • Findings suggest that oxytocin is a promising candidate for new treatments for developmental disorders affecting social skills and bonding. (medindia.net)
  • These results are interpreted in the context of the organizational effects of oxytocin exposure in early life and these findings add to a growing literature on how the perinatal brain is sensitive to hormonal manipulations at birth . (bvsalud.org)
  • Oxytocin (OXT) is involved in the regulation of emotion, social cognition and metabolism, and our previous work showed that the OXT system is affected early in HD. (lu.se)
  • We've reported many times on the effects of oxytocin , which has been found to increase feelings of group affiliation and trust . (berkeley.edu)
  • In addition, the results contribute to a deeper understanding of oxytocin as a key hormone for socio-emotional effects. (unibas.ch)
  • This is supported by the author's further comment that "Further investigation in this area may reveal potential beneficial effects of oxytocin administration in early pregnancy. (equine-reproduction.com)
  • 9. The more oxytocin is released in the body, the more accumulative the effect, so long-term breastfeeding mothers benefit for the effects for years later! (natalhypnotherapy.co.uk)
  • When oxytocin is released into your bloodstream, stress levels are reduced because of the effects of oxytocin on the body. (naturaltherapypages.com.au)
  • Misoprostol may augment the effects oxytocic agents, especially when given less than 4 hours before initiating oxytocin. (medscape.com)
  • We further demonstrated that these chronic oxytocin effects result from 1) maintenance of energy expenditure at preintervention levels despite ongoing weight loss, 2) a reduction in respiratory quotient, consistent with increased fat oxidation, and 3) an enhanced satiety response to cholecystokinin-8 and associated decrease of meal size. (nih.gov)
  • These weight-reducing effects persisted for approximately 10 days after termination of 3V oxytocin administration and occurred independently of whether sucrose was added to the HFD. (nih.gov)
  • My work now is focused on the developmental effects of oxytocin. (medscape.com)
  • Today at the Endocrine Society Annual Meeting , I talked about the epigenetic effects of oxytocin. (medscape.com)
  • Roughly the same number of people in each group chose to donate-but those dosed with oxytocin gave 48 percent more money than people who took the placebo. (berkeley.edu)
  • Half of the participants were given measured doses of oxytocin, while the rest were offered a placebo. (psychcentral.com)
  • Oxytocin in response to MDMA provocation test in patients with arginine vasopressin deficiency (central diabetes insipidus): a single-centre, case-control study with nested, randomised, double-blind, placebo-controlled crossover trial. (unibas.ch)
  • And importantly, committed men who were given the placebo did not insist on the same distance as those administered oxytocin, an indication that the hormone discourages partnered - but not single men - from getting too close to a female stranger. (smithsonianmag.com)
  • Early social interaction with our caregivers, certainly including fathers, can influence our biological and psychological development through epigenetic changes to the oxytocin system. (mpg.de)
  • Amastatin, bestatin (ubenimex), leupeptin, and puromycin have been found to inhibit the enzymatic degradation of oxytocin, though they also inhibit the degradation of various other peptides, such as vasopressin, met-enkephalin, and dynorphin A. In the hypothalamus, oxytocin is made in magnocellular neurosecretory cells of the supraoptic and paraventricular nuclei, and is stored in Herring bodies at the axon terminals in the posterior pituitary. (wikipedia.org)
  • We think that oxytocin might normally act in the brain to inhibit intake only in certain types of feeding or drinking situations. (news-medical.net)
  • Interestingly, participants who received oxytocin on the first testing day retained the ability to assign affective significance to speech when they returned approximately two weeks later. (scienceagogo.com)
  • The infant monkeys inhaled an aerosolized dose of oxytocin in one session, and a saline dose in the other. (medindia.net)
  • Dose a group of people with oxytocin and it's group hugs all round. (null.org)
  • Oxytocin (Oxt or OT) is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. (wikipedia.org)
  • In the 1920s, oxytocin and vasopressin were isolated from pituitary tissue and given their current names. (wikipedia.org)
  • Oxytocin, a hormone produced by the pituitary gland, is involved in labor, birth and breast milk production. (medindia.net)
  • Produced by the hypothalamus and released by the pituitary gland, oxytocin is associated with social bonding, trust and emotional wellbeing. (naturaltherapypages.com.au)
  • Oxytocin deficiency in people with vasopressin deficiency would at least partially explain this finding," says the endocrinologist Atila. (unibas.ch)
  • Systemic vasopressin (VP) and oxytocin (OT) are chiefly produced by magnocellular neurosecretory cells (MNCs) in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. (jneurosci.org)
  • Indeed, in rodents, oxytocin can successfully fight unpleasant alcohol and heroin withdrawal symptoms. (time.com)
  • Simpson and colleagues describe the monkeys as being more communicative when they saw the caregivers, that is, making facial gestures more frequently after receiving oxytocin than they did after receiving the saline. (medindia.net)
  • Of course, the only study I turned up with a Korean context doesn't even mention oxytocin ( in the abstract, anyway ), just the touch, voice, and visual stimulation of orphaned infants and corresponding better rates of health and development. (gordsellar.com)
  • Greater maternal involvement seems to have the potential to upregulate the oxytocin system in babys. (mpg.de)
  • Previously, we found evidence for behavioral, epigenetic , and neuroendocrine consequences in adult prairie vole offspring following maternal oxytocin treatment immediately prior to birth . (bvsalud.org)
  • Here, we examined the neurodevelopmental consequences in adult prairie vole offspring following maternal oxytocin treatment prior to birth . (bvsalud.org)
  • The oxytocin peptide is composed of nine amino acids and has a molecular weight of 1007 daltons (Da). (naturaltherapypages.com.au)
  • In the early 1950s, American biochemist Vincent du Vigneaud found that oxytocin is made up of nine amino acids, and he identified its amino acid sequence, the first polypeptide hormone to be sequenced. (wikipedia.org)
  • Increasing oxytocin levels, therefore, might cue the reward system to react the way it does in the presence of the drug, relieving withdrawal. (time.com)
  • The children with higher methylation levels at 18-months, and presumably lower levels of oxytocin receptor, were also more temperamental and less well balanced. (mpg.de)
  • It seems initially counter-intuitive to consider oxytocin use to support pregnancy instead of Regumate or other altrenogest treatments which are commonly used to potentially increase - or at least maintain - progestin levels during early pregnancy in the mare. (equine-reproduction.com)
  • It has been shown previously that treatment of mares with oxytocin at certain levels and points in diestrus can maintain the corpus luteum beyond the stage where it would normally be lysed (functionally destroyed) by the naturally-occurring prostaglandin release towards the end of diestrus. (equine-reproduction.com)
  • McNaughten and Wallace explored the possibility of oxytocin use to support pregnancy instead of altrenogest, to assist with elevating progestin levels in a more natural manner. (equine-reproduction.com)
  • The Brain-NA-adrenaline Axis Controls the Fight-or-flight Response in the Hypothalamus Signals for a Multi-hormonal Adaptive Response Shifting Levels of Oxytocin, Serotonin, etc. (novapublishers.com)
  • One wonders whether, in such a social climate, violation of those rules would boost oxytocin levels - since it's more "touch" than normal - or whether the perceived increase might be dampened by other neurochemicals, especially stress-related ones. (gordsellar.com)
  • You know who they should do a study of oxytocin levels for? (gordsellar.com)
  • The role of oxytocin in maintaining health and wellness is huge, so this article takes you through various natural therapies for increasing the levels of oxytocin in your body. (naturaltherapypages.com.au)
  • For instance, massage therapy, known for its relaxation benefits, has been shown to boost oxytocin levels, promoting a sense of calm and reducing stress. (naturaltherapypages.com.au)
  • Mindfulness practices, such as meditation and yoga, encourage a state of present-moment awareness and can enhance oxytocin levels, thereby improving emotional wellbeing. (naturaltherapypages.com.au)
  • Animal-assisted therapy, involving interactions with therapy animals, has also been linked to increased oxytocin levels. (naturaltherapypages.com.au)
  • To conduct research on the connection between oxytocin and emotion, scientists want to assess the hormone's levels in the brain. (stanford.edu)
  • The volunteers agreed to have oxytocin levels measured in their blood and CSF, and the parents of 10 children in the study answered questions about their children's anxiety levels. (stanford.edu)
  • Salivary oxytocin was measured before and after the behavioral tasks. (frontiersin.org)
  • The team found that oxytocin increased activations in brain regions known to process social information. (sciencedaily.com)
  • And oxytocin was found to help dramatically. (time.com)
  • The oxytocin receptor is found in various tissues in the human body, including in a woman's breast and uterus, and in both male and female testicles. (naturaltherapypages.com.au)
  • In the context of natural therapy, various practices have been found to stimulate oxytocin release. (naturaltherapypages.com.au)
  • Beyond its role in social bonding and emotional healing, oxytocin has been found to have analgesic properties, making it relevant in pain management through natural therapies. (naturaltherapypages.com.au)
  • We found that chronic 3V oxytocin infusion between 21 and 26 days by osmotic minipumps both reduced weight gain associated with the progression of high-fat diet (HFD)-induced obesity and elicited a sustained reduction of fat mass with no decrease of lean mass in rats with established diet-induced obesity. (nih.gov)
  • In addition to reduced stress, other benefits associated with increased oxytocin production include lower blood pressure, higher empathy with others and better social behaviour. (naturaltherapypages.com.au)
  • Recent studies have shown that oxytocin may modulate social recognition in both sexes, and thus it may be related to empathy. (frontiersin.org)
  • The goal of the current work is to determine whether long-term third ventricular (3V) infusion of oxytocin into the central nervous system (CNS) is effective for obesity prevention and/or treatment in rat models. (nih.gov)
  • If the uterus does not contract after massage alone, oxytocin 10 units IM or a dilute oxytocin IV infusion (10 or 20 [up to 80] units/1000 mL of IV fluid) at 125 to 200 mL/hour is given immediately after delivery of the placenta. (msdmanuals.com)
  • Prior research has suggested that oxytocin makes people more likely to give directly to another person when they're encouraged to empathize with that person. (berkeley.edu)
  • Research has long suggested that oxytocin- called the "love" or "hug" hormone for its role in social bonding- is a complicated chemical. (time.com)
  • Oxytocin administration seems to improve efficiency of HIFU therapy although further research is required to assess its value. (hindawi.com)
  • Earlier research of oxytocin paints a very rosy view of it. (null.org)
  • In the new research, Zak and his colleagues find that when someone observes that another person trusts them, oxytocin - a hormone that circulates in the brain and the body - rises. (null.org)
  • A little oxytocin seems to be good, but large doses can disrupt the process-especially the development of the baby. (medscape.com)
  • Oxytocin is released into the bloodstream as a hormone in response to sexual activity and during labour. (wikipedia.org)
  • What is the clinical effectiveness of oxytocin administered with the use of a safety checklist for labour induction and augmentation? (cadth.ca)
  • The costs of induction of labour by prostaglandin E2 or oxytocin : refining the estimates / Linda Davies, Michael Drummond. (who.int)
  • The study highlights the important role of oxytocin in altruism. (berkeley.edu)
  • Studies have also shown that oxytocin plays a role in parental bonding, mating and social interactions. (medindia.net)
  • The study investigated what role oxytocin had in memory. (theconversation.com)
  • A new study reports the oxytocin receptor plays a special role in the ability to remember faces. (neurosciencenews.com)
  • Oxytocin plays a crucial role in natural therapy, fostering a sense of connection and healing. (naturaltherapypages.com.au)
  • The mind-body connection is a fundamental aspect of natural therapy, and oxytocin plays a key role in nurturing emotional healing. (naturaltherapypages.com.au)
  • By understanding the role of oxytocin in the mind-body connection, individuals can incorporate these natural therapy approaches into their lives to nurture emotional wellbeing and healing. (naturaltherapypages.com.au)
  • It is released during orgasm and birth and other bonding moments between lovers or family members, but oxytocin may also help create the unhealthy ties that bind alcoholics and addicts to their drugs of choice. (time.com)
  • There is a surging oxytocin release after birth that causes your senses to be intensified, allowing you to connect with the smell and feel of your baby. (medela.us)
  • I am especially concerned because oxytocin is widely manipulated in birth. (medscape.com)
  • Neuroanatomical and functional consequences of oxytocin treatment at birth in prairie voles. (bvsalud.org)
  • New study: People give more when under the influence of oxytocin. (berkeley.edu)
  • The aim of the study was to evaluate the clinical efficacy of magnetic resonance-guided High-Intensity Focused Ultrasound (HIFU) in patients with symptomatic uterine fibroids (myomata) after application of oxytocin. (hindawi.com)
  • Ruth Feldman, psychology professor at Bar-Ilan University in Israel, conducted the first study to demonstrate the links between oxytocin and bonding in human mothers. (science20.com)
  • I had a great today attending the study day by Kersten Uvnas Moberg on the Oxytocin factor. (natalhypnotherapy.co.uk)
  • In the present study, we investigated the relationship between salivary oxytocin concentration and the feeling of rubber hand ownership. (frontiersin.org)