Oxylipins
Lipoxygenase
Galactolipids
Fatty Acids, Unsaturated
Diatoms
Protozoan Infections
Helminths
Plant Leaves
Eicosanoids
Arabidopsis
Pseudomonas syringae
Intramolecular Oxidoreductases
Enzymes of the isomerase class that catalyze the oxidation of one part of a molecule with a corresponding reduction of another part of the same molecule. They include enzymes converting aldoses to ketoses (ALDOSE-KETOSE ISOMERASES), enzymes shifting a carbon-carbon double bond (CARBON-CARBON DOUBLE BOND ISOMERASES), and enzymes transposing S-S bonds (SULFUR-SULFUR BOND ISOMERASES). (From Enzyme Nomenclature, 1992) EC 5.3.
Gene Expression Regulation, Plant
Fungi
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
Plants
Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.
Plant Proteins
Plants, Genetically Modified
Molecular Structure
Arabidopsis Proteins
Plant Roots
Fatty Acids
Drug Evaluation, Preclinical
Chromatography, High Pressure Liquid
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Mutation
alpha-Linolenic Acid
Arachidonic Acid
An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
Fatty Acids, Omega-3
A group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. These fatty acids are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.
Dietary Supplements
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
Fatty Acids, Omega-6
Carrageenan
Nociception
Lipid Peroxidation
Edema
Platelet Aggregation
Alternaria
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Gene Expression Profiling
Formation of lipoxygenase-pathway-derived aldehydes in barley leaves upon methyl jasmonate treatment. (1/1093)
In barley leaves, the application of jasmonates leads to dramatic alterations of gene expression. Among the up-regulated gene products lipoxygenases occur abundantly. Here, at least four of them were identified as 13-lipoxygenases exhibiting acidic pH optima between pH 5.0 and 6.5. (13S,9Z,11E,15Z)-13-hydroxy-9,11,15-octadecatrienoic acid was found to be the main endogenous lipoxygenase-derived polyenoic fatty acid derivative indicating 13-lipoxygenase activity in vivo. Moreover, upon methyl jasmonate treatment > 78% of the fatty acid hydroperoxides are metabolized by hydroperoxide lyase activity resulting in the endogenous occurrence of volatile aldehydes. (2E)-4-Hydroxy-2-hexenal, hexanal and (3Z)- plus (2E)-hexenal were identified as 2,4-dinitro-phenylhydrazones using HPLC and identification was confirmed by GC/MS analysis. This is the first proof that (2E)-4-hydroxy-2-hexenal is formed in plants under physiological conditions. Quantification of (2E)-4-hydroxy-2-hexenal, hexanal and hexenals upon methyl jasmonate treatment of barley leaf segments revealed that hexenals were the major aldehydes peaking at 24 h after methyl jasmonate treatment. Their endogenous content increased from 1.6 nmol.g-1 fresh weight to 45 nmol.g-1 fresh weight in methyl-jasmonate-treated leaf segments, whereas (2E)-4-hydroxy-2-hexenal, peaking at 48 h of methyl jasmonate treatment increased from 9 to 15 nmol.g-1 fresh weight. Similar to the hexenals, hexanal reached its maximal amount 24 h after methyl jasmonate treatment, but increased from 0.6 to 3.0 nmol.g-1 fresh weight. In addition to the classical leaf aldehydes, (2E)-4-hydroxy-2-hexenal was detected, thereby raising the question of whether it functions in the degradation of chloroplast membrane constituents, which takes place after methyl jasmonate treatment. (+info)Inverse relationship between systemic resistance of plants to microorganisms and to insect herbivory. (2/1093)
Pre-inoculation of plants with a pathogen that induces necrosis leads to the development of systemic acquired resistance (SAR) to subsequent pathogen attack [1]. The phenylpropanoid-derived compound salicylic acid (SA) is necessary for the full expression of both local resistance and SAR [2] [3]. A separate signaling pathway involving jasmonic acid (JA) is involved in systemic responses to wounding and insect herbivory [4] [5]. There is evidence both supporting and opposing the idea of cross-protection against microbial pathogens and insect herbivores [6] [7]. This is a controversial area because pharmacological experiments point to negative cross-talk between responses to systemic pathogens and responses to wounding [8] [9] [10], although this has not been demonstrated functionally in vivo. Here, we report that reducing phenylpropanoid biosynthesis by silencing the expression of phenylalanine ammonialyase (PAL) reduces SAR to tobacco mosaic virus (TMV), whereas overexpression of PAL enhances SAR. Tobacco plants with reduced SAR exhibited more effective grazing-induced systemic resistance to larvae of Heliothis virescens, but larval resistance was reduced in plants with elevated phenylpropanoid levels. Furthermore, genetic modification of components involved in phenylpropanoid synthesis revealed an inverse relationship between SA and JA levels. These results demonstrate phenylpropanoid-mediated cross-talk in vivo between microbially induced and herbivore-induced pathways of systemic resistance. (+info)EIN2, a bifunctional transducer of ethylene and stress responses in Arabidopsis. (3/1093)
Ethylene regulates plant growth, development, and responsiveness to a variety of stresses. Cloning of the Arabidopsis EIN2 gene identifies a central component of the ethylene signaling pathway. The amino-terminal integral membrane domain of EIN2 shows similarity to the disease-related Nramp family of metal-ion transporters. Expression of the EIN2 CEND is sufficient to constitutively activate ethylene responses and restores responsiveness to jasmonic acid and paraquat-induced oxygen radicals to mutant plants. EIN2 is thus recognized as a molecular link between previously distinct hormone response pathways. Plants may use a combinatorial mechanism for assessing various stresses by enlisting a common set of signaling molecules. (+info)The jasmonate-induced 60 kDa protein of barley exhibits N-glycosidase activity in vivo. (4/1093)
Upon jasmonate treatment barley leaf segments express a putative ribosome-inactivating protein (JIP60). The influence of this protein on translation in planta has been analysed by using barley plants and tobacco plants transformed with a barley cDNA encoding JIP60. In both plant systems JIP60 exhibited N-glycosidase activity in vivo. The depurination of the 25S rRNA of tobacco and barley ribosomes led to accumulation of translationally inactive polysomes. (+info)A novel jasmonate- and elicitor-responsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts with a jasmonate- and elicitor-inducible AP2-domain transcription factor, ORCA2. (5/1093)
Jasmonate (JA) is an important plant stress hormone that induces various plant defense responses, including the biosynthesis of protective secondary metabolites. The induction of the secondary metabolite biosynthetic gene Strictosidine synthase (Str) in Catharanthus roseus (periwinkle) cells by elicitor requires JA as a second messenger. A 42 bp region in the Str promoter is both necessary and sufficient for JA- and elicitor-responsive expression. This region is unlike other previously identified JA-responsive regions, and contains a GCC-box-like element. Yeast one-hybrid screening identified cDNAs encoding two AP2-domain proteins. These octadecanoid-derivative responsive Catharanthus AP2-domain (ORCA) proteins bind in a sequence-specific manner the JA- and elicitor-responsive element. ORCA2 trans-activates the Str promoter and its expression is rapidly inducible with JA and elicitor, whereas Orca1 is expressed constitutively. The results indicate that a GCC-box-like element and ORCA2 play key roles in JA- and elicitor-responsive expression of the terpenoid indole alkaloid biosynthetic gene Str. (+info)Oligogalacturonide-mediated induction of a gene involved in jasmonic acid synthesis in response to the cell-wall-degrading enzymes of the plant pathogen Erwinia carotovora. (6/1093)
Identification of Arabidopsis thaliana genes responsive to plant cell-wall-degrading enzymes of Erwinia carotovora subsp. carotovora led to the isolation of a cDNA clone with high sequence homology to the gene for allene oxide synthase, an enzyme involved in the biosynthesis of jasmonates. Expression of the corresponding gene was induced by the extracellular enzymes from this pathogen as well as by treatment with methyl jasmonate and short oligogalacturonides (OGAs). This suggests that OGAs are involved in the induction of the jasmonate pathway during plant defense response to E. carotovora subsp. carotovora attack. (+info)Differential induction of plant volatile biosynthesis in the lima bean by early and late intermediates of the octadecanoid-signaling pathway. (7/1093)
Plants are able to respond to herbivore damage with de novo biosynthesis of an herbivore-characteristic blend of volatiles. The signal transduction initiating volatile biosynthesis may involve the activation of the octadecanoid pathway, as exemplified by the transient increase of endogenous jasmonic acid (JA) in leaves of lima bean (Phaseolus lunatus) after treatment with the macromolecular elicitor cellulysin. Within this pathway lima bean possesses at least two different biologically active signals that trigger different biosynthetic activities. Early intermediates of the pathway, especially 12-oxo-phytodienoic acid (PDA), are able to induce the biosynthesis of the diterpenoid-derived 4,8, 12-trimethyltrideca-1,3,7,11-tetraene. High concentrations of PDA result in more complex patterns of additional volatiles. JA, the last compound in the sequence, lacks the ability to induce diterpenoid-derived compounds, but is highly effective at triggering the biosynthesis of other volatiles. The phytotoxin coronatine and amino acid conjugates of linolenic acid (e.g. linolenoyl-L-glutamine) mimic the action of PDA, but coronatine does not increase the level of endogenous JA. The structural analog of coronatine, the isoleucine conjugate of 1-oxo-indanoyl-4-carboxylic acid, effectively mimics the action of JA, but does not increase the level of endogenous JA. The differential induction of volatiles resembles previous findings on signal transduction in mechanically stimulated tendrils of Bryonia dioica. (+info)Requirement of functional ethylene-insensitive 2 gene for efficient resistance of Arabidopsis to infection by Botrytis cinerea. (8/1093)
Inoculation of wild-type Arabidopsis plants with the fungus Alternaria brassicicola results in systemic induction of genes encoding a plant defensin (PDF1.2), a basic chitinase (PR-3), and an acidic hevein-like protein (PR-4). Pathogen-induced induction of these three genes is almost completely abolished in the ethylene-insensitive Arabidopsis mutant ein2-1. This indicates that a functional ethylene signal transduction component (EIN2) is required in this response. The ein2-1 mutants were found to be markedly more susceptible than wild-type plants to infection by two different strains of the gray mold fungus Botrytis cinerea. In contrast, no increased fungal colonization of ein2-1 mutants was observed after challenge with avirulent strains of either Peronospora parasitica or A. brassicicola. Our data support the conclusion that ethylene-controlled responses play a role in resistance of Arabidopsis to some but not all types of pathogens. (+info)
Imaging Unit: Leibniz-Institut für Pflanzenbiochemie
Phosphorylation-Coupled Proteolysis of the Transcription Factor MYC2 Is Important for Jasmonate-Signaled Plant Immunity
Molecular pathways linking oxylipins to nociception in rats. | Physicians Weekly
LOX-DB - LipOXygenases DataBase - Literature
Publication : USDA ARS
An endogenous danger detection system in Arabidopsis thaliana: the AtPep peptides and their receptors - edoc
A Role for the GCC-Box in Jasmonate-Mediated Activation of the PDF1.2 Gene of Arabidopsis | Plant Physiology
Journal: Plant physiology / Publication Year: 1997 / Subject: jasmonic acid and protein composition / Text Availability:...
Journal: Plant physiology / Source: 1997 v.114 no.2 / Subject: jasmonic acid - PubAg Search Results
What is Jasmonic Acid (JA)? - Definition from Hydrolife
Publikationen: Leibniz-Institut für Pflanzenbiochemie
Full-length transcriptome sequencing and methyl jasmonate-induced expression profile analysis of genes related to patchoulol...
COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility. - PubMed - NCBI
Xylem-Mobile Oxylipins Are Critical Regulators of Induced Systemic Resistance in Maize | Plant Cell
Final Report Summary - OXYLIPIN SIGNALLING (Oxylipin signalling in plant defence against pathogens) | Report Summary | OXYLIPIN...
Oligogalacturonides Induce Proteinase Inhibitor Synthesis Via the Octadecanoid Pathway | Springer for Research & Development
Mass Spectrometric Approaches to Study the Metabolism of Jasmonates: Biotransformation of Exogenously Supplemented Methyl...
Jasmonates: Synthesis, Metabolism, Signal Transduction and Action
Experiments Underscore Overlooked Aspect of Defending Corn from Pest | CropWatch | University of Nebraska-Lincoln
Expression of α-DIOXYGENASE 1 in Tomato and Arabidopsis Contributes to Plant Defenses Against Aphids
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Inhibition of Wound-Induced Accumulation of Allene Oxide Synthase Transcripts in Flax Leaves by Aspirin and Salicylic Acid |...
Kinetics of salicylate-mediated suppression of jasmonate signaling reveal a role for redox modulation
Jasmonate - Wikipedia
中国科学院昆明植物研究所知识管理系统(KIB OpenIR): Silencing JA hydroxylases in Nicotiana attenuata enhances jasmonic acid-isoleucine-mediated...
The transcriptome of rhizobacteria-induced systemic resistance in Arabidopsis.
Wounding and Insect Feeding Trigger Two Independent MAPK Pathways with Distinct Regulation and Kinetics | Plant Cell
The roles of jasmonate signalling in nitrogen u...
IJMS | Free Full-Text | Buckwheat (Fagopyrum esculentum M.) Sprout Treated with Methyl Jasmonate (MeJA) Improved Anti...
Publication : USDA ARS
OPR3 - 12-oxophytodienoate reductase 3 - Solanum lycopersicum (Tomato) - OPR3 gene & protein
Publishers of academic thesis & dissertations. Free search & preview. PDF downloads. Instant access to paperback & ebook...
个人详细信息
Jasmonate and salicylate as global signals for defense gene expression
Differential Induction of Tobacco MAP Kinases by the Defense Signals Nitric Oxide, Salicylic Acid, Ethylene, and Jasmonic Acid
A bHLH-type transcription factor, ABA-INDUCIBLE BHLH-TYPE TRANSCRIPTION FACTOR/JA-ASSOCIATED MYC2-LIKE1, acts as a repressor to...
Oxylipins | Harvard Catalyst Profiles | Harvard Catalyst
Browsing Biochemistry and Cell Biology by Subject plant-insect interaction
The Arabidopsis hrl1 mutation reveals novel overlapping roles for salicylic acid, jasmonic acid and ethylene signalling in cell...
Methyl jasmonate Archives - Terpenes and Testing Magazine
methyl jasmonate uses Archives - Terpenes and Testing Magazine
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Divinylether fatty acids
Göbel, C; Feussner, I.; Hamberg M, M.; Rosahl, S. (5 September 2002). "Oxylipin profiling in pathogen-infected potato leaves". ... Jiang, Z. D.; Gerwick, William H. (1 March 1997). "Novel oxylipins from the temperate red alga Polyneura latissima". Lipids. 32 ... detection of the novel divinyl ether oxylipins". FEBS Letters. 371 (2): 159-162. doi:10.1016/0014-5793(95)00895-G. PMID 7672118 ...
Sponge isolates
2006). "Cytotoxic oxylipins from a marine sponge Topsentia sp". J Nat Prod. 69 (4): 567-71. doi:10.1021/np0503552. PMID ...
Lipoxygenase
Gabbs M, Leng S, Devassy JG, Monirujjaman M, Aukema HM (2015). "Advances in Our Understanding of Oxylipins Derived from Dietary ... KenjiMatsui (2006). "Green leaf volatiles: hydroperoxide lyase pathway of oxylipin metabolism". Current Opinion in Plant ...
Eicosanoid
... s are a sub-category of oxylipins, i.e. oxidized fatty acids of diverse carbon units in length, and are distinguished ... Gabbs M, Leng S, Devassy JG, Monirujjaman M, Aukema HM (2015). "Advances in Our Understanding of Oxylipins Derived from Dietary ... from other oxylipins by their overwhelming importance as cell signaling molecules. Eicosanoids function in diverse ...
Polyunsaturated aldehyde
... s are oxylipins that are formed from lipids (specifically the fatty acid portion of lipids) when ... "Chemistry of oxylipin pathways in marine diatoms". Pure and Applied Chemistry. 79 (4): 481-490. doi:10.1351/pac200779040481. ...
Methyl jasmonate
Christie, William W. Plant oxylipins: Chemistry and biology, 22 May 2014. Archived from the original on 2015-06-30. Retrieved ...
Sponge
One such class is the oxidized fatty acid derivatives called oxylipins. Members of this family have been found to have anti- ...
Green leaf volatiles
Matsui K (2006). "Green leaf volatiles: hydroperoxide lyase pathway of oxylipin metabolism". Current Opinion in Plant Biology. ...
Plant hormone
Browse J (2005). "Jasmonate: an oxylipin signal with many roles in plants". Plant Hormones. Vitamins & Hormones. 72. pp. 431-56 ...
Cis-3-Hexenal
CS1 maint: discouraged parameter (link) KenjiMatsui (2006). "Green leaf volatiles: hydroperoxide lyase pathway of oxylipin ...
CYP74 family
Lee, DS; Nioche, P; Hamberg, M; Raman, CS (18 September 2008). "Structural insights into the evolutionary paths of oxylipin ...
Effects of cannabis
Wu J, Gouveia-Figueira S, Domellöf M, Zivkovic AM, Nording ML (January 2016). "Oxylipins, endocannabinoids, and related ...
Breast milk
Wu J, Gouveia-Figueira S, Domellöf M, Zivkovic AM, Nording ML (January 2016). "Oxylipins, endocannabinoids, and related ...
Jasmonate
... s (JA) are an oxylipin, i.e. a derivative of oxygenated fatty acid. It is biosynthesized from linolenic acid in ... Reinbothe, C; Springer, A; Samol, I; Reinbothe, S (September 2009). "Plant oxylipins: role of jasmonic acid during programmed ...
N-Acylethanolamine
September 2017). "The oxylipin and endocannabidome responses in acute phase Plasmodium falciparum malaria in children". Malaria ... "Formation of a new class of oxylipins from N-acyl(ethanol)amines by the lipoxygenase pathway". European Journal of Biochemistry ... to produce ethanolamide oxylipins, like prostaglandin ethanolamides (prostamide) by COX-2, with various potential bioactivities ...
Effects of cannabis
Wu J, Gouveia-Figueria S, Domellöf M, Zivkovic AM, Nording ML (2016). "Oxylipins, endocannabinoids, and related compounds in ...
Plakevulin A
... a new oxylipin inhibiting DNA polymerases α and γ from sponge Plakortis species". Tetrahedron. 59 (8): 1137. doi:10.1016/S0040- ...
Ecklonia stolonifera
The oxylipins ecklonialactones A, B, C, D, E and F and fucosterol can also be isolated from the species. Kuda, Takashi; Kunii, ... Novel Oxylipins from Brown Algae of the Genera Ecklonia and Egregia". Journal of Natural Products. 57 (1): 171-4. doi:10.1021/ ...
13-Hydroxyoctadecadienoic acid
"Profiling the Oxylipin and Endocannabinoid Metabolome by UPLC-ESI-MS/MS in Human Plasma to Monitor Postprandial Inflammation" ...
Linoleate 9S-lipoxygenase
Vellosillo T, Martínez M, López MA, Vicente J, Cascón T, Dolan L, Hamberg M, Castresana C (March 2007). "Oxylipins produced by ...
13-Hydroxyoctadecadienoic acid
Gouveia-Figueira, Sandra; Späth, Jana; Zivkovic, Angela M; Nording, Malin L (2015). "Profiling the Oxylipin and Endocannabinoid ...
Phytobiome
Other organisms can interfere with fungal signaling, such as plant-produced oxylipins that mimic fungal signaling molecules and ...
Linoleate 10R-lipoxygenase
12-octadecadienoate Linoleate 10R-lipoxygenase is involved in biosynthesis of oxylipins. Garscha U, Oliw EH (May 2009). " ...
Systemin
It is likely that VOC production is upregulated through different pathways, including oxylipin pathway that synthesises ...
Turbinellus floccosus
The fruit body of T. floccosus produces oxylipin (lipids generated by oxygenation of fatty acids) that are active against the ...
Volatolomics
... induce differential changes in volatile compound release and oxylipin synthesis. J. Exp. Bot. 60, 1231-1240 (2009). Wenke, K., ...
Linolenate 9R-lipoxygenase
15-trienoate In cyanobacteria the enzyme is involved in oxylipin biosynthesis. Jernerén F, Hoffmann I, Oliw EH (March 2010). " ...
ஒமேகா-3 கொழுப்பு அமிலம் - தமிழ் விக்கிப்பீடியா
August 2009) Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters. J Lipid ...
Oxylipin
Most oxylipins in the body are derived from linoleic acid or alpha-linolenic acid. Linoleic acid oxylipins are usually present ... Many of oxylipins have physiological significance. Typically, oxylipins are not stored in tissues but are formed on demand by ... despite the fact that alpha-linolenic acid is more readily metabolized to oxylipin. Linoleic acid oxylipins can be anti- ... Oxylipins constitute a family of oxygenated natural products which are formed from fatty acids by pathways involving at least ...
Oxylipin - Wikipedia
Most oxylipins in the body are derived from linoleic acid or alpha-linolenic acid. Linoleic acid oxylipins are usually present ... Many of oxylipins have physiological significance. Typically, oxylipins are not stored in tissues but are formed on demand by ... despite the fact that alpha-linolenic acid is more readily metabolized to oxylipin. Linoleic acid oxylipins can be anti- ... Oxylipins constitute a family of oxygenated natural products which are formed from fatty acids by pathways involving at least ...
Oxylipin analysis methods. - PubMed - NCBI
Oxylipin analysis methods.. Mueller MJ1, Mène-Saffrané L, Grun C, Karg K, Farmer EE. ... Additional information on oxylipin quantification and novel protocols for preparing oxygen isotope-labelled internal standards ... Four developing areas of research are identified: (i) profiling of the unbound cellular pools of oxylipins; (ii) profiling of ... enes and hydroxy-fatty acids as well as detecting the presence of novel oxylipins are presented. Additionally, a protocol for ...
Goettingen, Plant Oxylipins
Oxylipins in Plant Defence Reactions Chairperson: Jose Sanchez-Serrano 9.10-9.40 David Hannapel (Ames, IA, USA): "The role of ... Oxylipins in Plant Development Delker C., Halle/D: The allene oxide cyclase family of Arabidopsis thaliana. Miersch O., Halle/ ... Oxylipins in Plant Development I Chairperson: Ivo Feussner 16.30-17.00 John Browse (Pullman, WA, USA): "Transcript Profiling ... Oxylipins in Plant Development II. Chairperson: Ivo Feussner 8.30-8.50 George Sellhorn (Pullman, WA, USA): Linking cellular ...
Oxylipins | Harvard Catalyst Profiles | Harvard Catalyst
Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. Proc Natl Acad Sci U S A. 2018 09 11; 115(37):9252 ... Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study. J Lipid Res. 2016 07; 57( ... "Oxylipins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Oxylipins" by people in Harvard Catalyst Profiles by year, and ...
Laboratory of oxylipins - IBCh RAS
... oxylipins; endocannabinoids; endovanilloids; biochemistry; lipids; neurochemistry; cell biology; neurodegeneration; cancer; ... oxylipin.ibch.ru oxylipins; endocannabinoids; endovanilloids; biochemistry; lipids; neurochemistry; cell biology; ... Laboratory of oxylipins Department of molecular bases of neurosignalization Head: Vladimir Bezuglov, D.Sc, professor. [email protected] ... The main object of the Laboratorys research is natural oxylipins (prostaglandins, etc.), natural neurolypes (conjugates of ...
Marine Drugs | Free Full-Text | Algal Oxylipins Mediate the Resistance of Diatoms against Algicidal Bacteria
The oxylipin production may represent an independent line of defense of the resistant alga, acting in addition to the ... Here, we show that the diatom Chaetoceros didymus releases eicosanoid oxylipins into the medium, and that the lytic algicidal ... Among the upregulated oxylipins, hydroxylated eicosapentaenoic acids (HEPEs) dominate. However, also, resolvins, known lipid ... bacterium, Kordia algicida, induces the production of several wound-activated oxylipins in this resistant diatom. Neither ...
Plasma oxylipins are influenced by sex and n-3 fatty acid supplement type
Oxygenated derivates of PUFAs, or oxylipins, are formed from multiple enzymatic reactions, and oxylipins have multiple ... Of the DHA oxylipins measured, nine reached a plateau in the females, but only 4 reached a plateau in the male subjects. Some ... Plasma oxylipins are influenced by sex and n-3 fatty acid supplement type. March 31, 2021 by Nancy Turner, PhD ... There are a variety of factors that can influence the production of oxylipins, such as sex and age, metabolism and their ...
TNO Repository search for: subject:'Oxylipin'
The dysregulation of these oxylipins revealed the presence of ROS-generated oxylipins and an increase of inflammation in CIA ... Oxylipins play important roles in various biological processes and are considered as mediators of inflammation for a wide range ... Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma article. 2015 ... Biology · Collagen type 2 · Lipopolysaccharide · Oxylipin · Animal experiment · Animal model · Arthritis · Articular cartilage ...
9-Lipoxygenase Oxylipin Pathway in Plant Response to Biotic Stress - Digital Library
This increase in LOX5 expression is paralleled by an increase in LOX5-synthesized oxylipins in the root and petiole exudates of ... Nalam, Vamsi J. 9-Lipoxygenase Oxylipin Pathway in Plant Response to Biotic Stress, dissertation, May 2012; Denton, Texas. ( ... This increase in LOX5 expression is paralleled by an increase in LOX5-synthesized oxylipins in the root and petiole exudates of ...
IJMS | Free Full-Text | Effect of Omega-3 Fatty Acid Supplementation on Oxylipins in a Routine Clinical Setting
... and subsequent formation of oxylipins with specific anti-inflammatory or anti-arrhythmic effects. In this study, we report the ... as well as plasma oxylipin patterns, in a patient population with severe hyperlipidemia and cardiovascular disease who are on ... Keywords: omega-3 fatty acids; oxylipins; lipidomics; lipid clinic; hyperlipidemia omega-3 fatty acids; oxylipins; lipidomics; ... Effect of Omega-3 Fatty Acid Supplementation on Oxylipins in a Routine Clinical Setting by Christoph Schmöcker 1,2,†, Ingrid W ...
The oxylipin and endocannabidome responses in acute phase Plasmodium falciparum malaria in children
... Surowiec, Izabella Umeå ... Three oxylipins (13-HODE, 9-HODE and 13-oxo-ODE) were higher in severe compared to uncomplicated malaria cases according to the ... Oxylipins, Endocannabinoids, Malaria infection, Plasmodium falciparum HSV kategori Identifikatorer. URN: urn:nbn:se:umu:diva- ... Observed changes in oxylipin levels can be connected to activation of cytochrome P450 (CYP) and 5-lipoxygenase (5-LOX) ...
Oxidation of Membrane Lipids and Functions of Oxylipins | Springer for Research & Development
Blée E (2002) Impact of phyto-oxylipins in plant defense. Trends Plant Sci 7: 315-321PubMedCrossRefGoogle Scholar ... Stelmach BA, Müller A, Henning P, Gebhardt S, Schu-bert-Zsilavecz M and Weiler EW (2001) A novel class of oxylipins, sn-1-O-(12 ... Matsui K (2006) Green leaf volatiles: hydroperoxide lyase pathway of oxylipin metabolism. Curr Opin Plant Biol 9: 274-280PubMed ... Staswick P and Tiryaki I (2004) The oxylipin signal jas-monic acid is activated by an enzyme that conjugates it to isoleucine ...
Molecular pathways linking oxylipins to nociception in rats. | Physician's Weekly
The study of oxylipins in nociception has presented technical challenges leading to critical knowledge gaps in the way these ... Effects of oxylipins depend on tissue-specific differences in accumulation of precursor polyunsaturated fatty acids and the ... Oxylipins are lipid peroxidation products that participate in nociceptive, inflammatory, and vascular responses to injury. ... Finally, when oxylipins were administered by intradermal injection we observed modulation of nociceptive thermal ...
Production of Eicosanoids and Other Oxylipins by Pathogenic Eukaryotic Microbes | Clinical Microbiology Reviews
Bioprospecting for novel oxylipins in fungi: the presence of 3-hydroxy oxylipins in Pilobolus. Antonie van Leeuwenhoek 80:93-99 ... OXYLIPIN PRODUCTION AS A TARGET OF INHIBITION. As has been discussed above, many parasites possess a unique system of oxylipin ... Oxylipins are oxygenated metabolites of fatty acids. Eicosanoids are a subset of oxylipins and include the prostaglandins and ... Oxygenated lipids are collectively known as oxylipins. One of the most biologically important groups of oxylipins in mammals is ...
Defense Activated by 9-Lipoxygenase-Derived Oxylipins Requires Specific Mitochondrial Proteins | Plant Physiology
Studies on the response of plants to 9-HOT revealed that the defensive activity of this oxylipin was, at least in part, due to ... The JA pathway of the oxylipin metabolome is initiated by 13-lipoxygenase and results in the formation of (+)-7-iso-JA and its ... 2012) Role of 9-lipoxygenase and α-dioxygenase oxylipin pathways as modulators of local and systemic defense. Mol Plant 5: 914- ... In addition, these results support previous findings pointing to the involvement of 9-HOT and of the 9-LOX oxylipin pathway in ...
Transcriptomic analysis of oxylipin biosynthesis genes and chemical profiling reveal an early induction of jasmonates in...
Transcriptomic analysis of oxylipin biosynthesis genes and chemical profiling reveal an early induction of jasmonates in ... Aim of the present work was to clarify the potential impact of the phyto-oxylipins pathway on drought tolerance of chickpea ( ... Therefore, we measured the expression of key genes involved in oxylipins metabolism by qPCR on samples from stressed and non- ... We further show that gene over-expression positively correlates with the levels of major oxylipin metabolites from the AOS ...
Final Report Summary - OXYLIPIN SIGNALLING (Oxylipin signalling in plant defence against pathogens) | Report Summary | OXYLIPIN...
Project context and objectives Oxylipin synthesis is triggered by various biotic and abiotic stresses as well as also taking ... Final Report Summary - OXYLIPIN SIGNALLING (Oxylipin signalling in plant defence against pathogens). Project context and ... Oxylipin synthesis is triggered by various biotic and abiotic stresses as well as also taking place during specific ... Oxylipins of the 9-LOX pathway, like Hydroxyoctadecatrienoic acid (9-HOT), have been shown to accumulate after pathogen ...
Intimal smooth muscle cells are a source but not a sensor of anti-inflammatory CYP450 derived oxylipins. | Sigma-Aldrich
Intimal smooth muscle cells are a source but not a sensor of anti-inflammatory CYP450 derived oxylipins.. [Scott Thomson, ... The CYP450-oxylipin - soluble epoxide hydrolase (sEH) pathway is currently of great interest in targeting for cardiovascular ... iSMCs are a rich source but not a sensor of anti-inflammatory epoxy-oxylipins. Complex lesions that contain high levels of ... We have investigated the expression of CYP450-oxylipin-sEH pathway enzymes and their metabolites in paired intimal (iSMC) and ...
Aronia-citrus juice (polyphenol-rich juice) intake and elite triathlon training: a lipidomic approach using representative...
... we examined whether particular urinary oxylipins (isoprostanes (IsoPs), leukotrienes (LTs), prostaglandins (PGs), and ... The beverage was a mixture of citrus juice (95%) and Aronia melanocarpa juice (5%) (ACJ). Fifty-two oxylipins were analyzed in ... In the present study, we examined whether particular urinary oxylipins (isoprostanes (IsoPs), leukotrienes (LTs), ... a lipidomic approach using representative oxylipins in urine L. A. García-Flores, S. Medina, C. Gómez, C. E. Wheelock, R. ...
Xylem-Mobile Oxylipins Are Critical Regulators of Induced Systemic Resistance in Maize | Plant Cell
The Oxylipins 12-OPDA and KODA are Potent Inducers of ISR. Wild-type maize receiver plants display dose-dependent resistance to ... Xylem-Mobile Oxylipins Are Critical Regulators of Induced Systemic Resistance in Maize. Philip Carella ... Xylem-Mobile Oxylipins Are Critical Regulators of Induced Systemic Resistance in Maize ... Xylem-Mobile Oxylipins Are Critical Regulators of Induced Systemic Resistance in Maize ...
Evaluation of the Antimicrobial Activities of Plant Oxylipins Supports Their Involvement in Defense against Pathogens | Plant...
Oxylipins. The oxylipins used in this study are listed in Table I and Figure 1. Many of them were prepared from the ... Estimation of the Stability of Oxylipins. Oxylipins (13-HPOT, 9-HPOT, 13-HOT, 9-HOT, 12-Oxo-PDA, 13-KOT, and CLn, 100 μm each) ... Structures of oxylipins and other compounds used in this work. Abbreviated names for oxylipins are as in Table I. ... Stability of Selected Oxylipins. Many oxylipins are chemically unstable and/or prone to degradation in the presence of ...
Oxylipins produced by the 9-lipoxygenase pathway regulate lateral root development and defense responses through a novel...
Clinical blood sampling for oxylipin analysis - effect of storage and pneumatic tube transport of blood on free and total...
4.2 Plasma oxylipin profile is more stable than serum and total oxylipins are more stable than free oxylipins. The extended ... 2.3 Extraction and quantification of oxylipins. Free oxylipins as well as total, i.e. free and esterified oxylipins were ... Free oxylipins. Total, i.e. free and esterified oxylipins. LLOQ [nM]. Mean ± SD [nM]. RSD [%]. ACL. LLOQ [nM]. Mean ± SD [nM]. ... 3.1 Levels of oxylipins in plasma and serum after immediate processing. Comparing free oxylipin levels in plasma and serum ...
Dietary polyacetylenic oxylipins falcarinol and falcarindiol prevent inflammation and colorectal neoplastic transformation: A...
Dietary polyacetylenic oxylipins falcarinol and falcarindiol prevent inflammation and colorectal neoplastic transformation: A ... Dietary polyacetylenic oxylipins falcarinol and falcarindiol prevent inflammation and colorectal neoplastic transformation: A ... Dietary polyacetylenic oxylipins falcarinol and falcarindiol prevent inflammation and colorectal neoplastic transformation : A ... Dietary polyacetylenic oxylipins falcarinol and falcarindiol prevent inflammation and colorectal neoplastic transformation : A ...
Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins
Changes in retinal N-acylethanolamines and their oxylipin derivatives during the development of visual impairment in a mouse...
The purpose of our study was to quantify changes in N-acylethanolamine species and their oxylipin derivatives in the retina of ... Methods : Levels of five N-acylethanolamine species and three NAE oxylipin derivatives were quantified in the retinae of 1.5 ( ... N-Acylethanolamines and NAE-oxylipins in retinal extracts were separated by reverse phase HPLC and derivatized with N,O-Bis( ... Changes in retinal N-acylethanolamines and their oxylipin derivatives during the development of visual impairment in a mouse ...
Modulation of the endogenous omega-3 fatty acid and oxylipin profile in vivo-A comparison of the fat-1 transgenic mouse with...
Modulation of the endogenous omega-3 fatty acid and oxylipin profile in vivo-A comparison of the fat-1 transgenic mouse with ... 7.8% following feeding). Changes in PUFAs were reflected in most oxylipins in plasma, brain and colon: Compared to wild-type ... In order to assess their power to modulate the fatty acid and oxylipin pattern, we thoroughly compared fat-1 and wild-type ... mice on a standard diet, arachidonic acid metabolites were overall decreased while EPA and DHA oxylipins increased with feeding ...
Potassium deficiency induces the biosynthesis of oxylipins and glucosinolates in Arabidopsis thaliana | BMC Plant Biology |...
Based on our results we propose that under K-deficiency plants produce oxylipins and glucosinolates to enhance their defense ... Oxylipin production and signaling in K-deficient plants. We have shown here that the levels of several oxylipins increase in K- ... Putative benefits of oxylipin and GLS accumulation under K-deficiency. The similarity of the changes of transcripts, oxylipins ... Response of oxylipin biosynthetic genes to K deficiency. Quantitative PCR analysis of selected oxylipin biosynthesis genes in ...
High-Throughput Profiling of Long Chain Fatty Acids and Oxylipins by LC-MS
In this work, we developed a high-throughput LC-MS method for analysis of 51 LCFAs and oxylipins. LCFAs and oxylipins were ... Oxylipins, oxygenated derivatives of LCFAs, regulate the activity of many cellular processes. Existing methods for the analysis ... Saturated and monounsaturated LCFAs were analyzed in single ion reaction mode, while polyunsaturated LCFAs and oxylipins were ... Using this method, we successfully quantified 31 LCFAs and oxylipins from mouse livers. ...
Oxylipins in triglyceride-rich lipoproteins of dyslipidemic subjects promote endothelial inflammation following a high fat meal.
We conclude the altered metabolism in dyslipidemic subjects produces TGRL with a unique oxylipin signature that promotes a pro- ... This study investigates how the relative abundance of oxygenated metabolites of PUFA, oxylipins, is altered in TGRL ... Concentrations of esterified and non-esterified fatty acids and oxylipins in TGRL were quantified by mass spectrometry. ... Oxylipins in triglyceride-rich lipoproteins of dyslipidemic subjects promote endothelial inflammation following a high fat meal ...
MetabolitesLipidsMetabolismLipoxygenasePathwaysPUFAMediatorsPathwayFormation of oxylipinsBiosynthesisAnti-inflammatoryNatural OxylipinsEndocannabinoidsEicosanoids and Related OxylipinsAcidsProstaglandinsPUFAsInflammationCompoundsEicosanoidJasmonicOmega-3 oxylipinsAnalysis of oxylipinsFunctions of OxylipinsProduction of oxylipinsDefenseBiologicalProduce oxylipinsDifferent oxylipinsPlantsSynthesisLipoxygenasesRegulatePathogensConcentrationsQuantificationFatty acidDerivativesPhenotypeEnzymaticCYP450MetabolomicsPlasmaEndogenousEicosapentaenoicProfilesAcidSigma-AldrichSignal transductionEukaryotic microbesMicrobialGenes
Metabolites12
- Results: Forty different oxylipin and thirteen endocannabinoid metabolites were detected in the studied samples, with one oxylipin (thromboxane B2, TXB2) in significantly lower levels and four endocannabinoids (OEA, PEA, DEA and EPEA) at significantly higher levels in infected individuals as compared to controls according to t test analysis with Bonferroni correction. (diva-portal.org)
- Oxylipins are oxygenated metabolites of fatty acids. (asm.org)
- We further show that gene over-expression positively correlates with the levels of major oxylipin metabolites from the AOS branch of the pathway, which finally leads to the synthesis of jasmonates. (nih.gov)
- We have investigated the expression of CYP450-oxylipin-sEH pathway enzymes and their metabolites in paired intimal (iSMC) and medial (mSMC) cells isolated from rat aorta. (sigmaaldrich.com)
- Plant oxylipins are a large family of metabolites derived from polyunsaturated fatty acids. (plantphysiol.org)
- Plant oxylipins represent a vast and diverse family of secondary metabolites, believed to occur in all higher plants. (plantphysiol.org)
- Changes in PUFAs were reflected in most oxylipins in plasma, brain and colon: Compared to wild-type mice on a standard diet, arachidonic acid metabolites were overall decreased while EPA and DHA oxylipins increased with feeding more than in fat-1 mice. (physiciansweekly.com)
- This study investigates how the relative abundance of oxygenated metabolites of PUFA, oxylipins, is altered in TGRL postprandially, and how these changes promote endothelial inflammation. (escholarship.org)
- Metabolomic analysis of the liver and plasma shows a positive correlation between obesity and hepatic C18 oxylipin metabolites of omega-6 (ω6) and omega-3 (ω3) fatty acids (linoleic and α-linolenic acid, respectively) in the cytochrome P450/soluble epoxide hydrolase pathway. (elsevier.com)
- The only generic term that adequately covers all of the relevant metabolites is oxylipin , defined as a family of oxygenated natural products that are formed from unsaturated fatty acids by pathways involving at least one step of dioxygen-dependent oxidation. (lipidhome.co.uk)
- Principal component (PC) analysis and multiple regression models were used to estimate associations of in utero PM2.5 exposure with oxylipin pathways and individual metabolites. (scilifelab.se)
- Mass spectrometry profiling of oxylipins, endocannabinoids, and N-acylethanolamines in human lung lavage fluids reveals responsiveness of prostaglandin E2 and associated lipid metabolites to biodiesel exhaust exposure. (diva-portal.org)
Lipids9
- Background: Oxylipins and endocannabinoids are low molecular weight bioactive lipids that are crucial for initiation and resolution of inflammation during microbial infections. (diva-portal.org)
- PERSPECTIVE: We applied a systems approach to characterize molecular pathways linking precursor lipids and oxylipins to nociceptive signaling. (physiciansweekly.com)
- Oxygenated lipids are collectively known as oxylipins. (asm.org)
- The oxygenation of unsaturated fatty acids by dioxygenases occurs in all kingdoms of life and produces physiologically important lipids called oxylipins. (uab.edu)
- The chemistry, biochemistry, pharmacology, and molecular biology of eicosanoids and related lipids, including the docosanoids and plant oxylipins, are vast, complex and occasionally contradictory subjects that continue to develop at an extraordinarily rapid rate. (lipidhome.co.uk)
- These pages are intended only as a broad overview of the topic that can be understood by scientists with some knowledge of lipids in general but not of oxylipins in particular. (lipidhome.co.uk)
- Here it is shown that 3-OH oxylipins can be detected in the SMA strain of Saccharomyces pastorianus grown in lab-scale fermentations without diazomethane by extracting cellular lipids with ethyl acetate, trimethylsilylating the total lipid extract and GC-MS identification using the diagnostic m/z 233 fragment. (dal.ca)
- 2nd International Conference on Non-Mammalian Eicosanoids, Bioactive Lipids and Plant Oxylipins. (usda.gov)
- Eicosanoids and other oxylipins, as well as endocannabinoids and related lipids, were quantified in plasma from 14 healthy volunteers at baseline and at three subsequent time points (2, 6, and 24 h) after 1 h exposure sessions. (diva-portal.org)
Metabolism5
- There are a variety of factors that can influence the production of oxylipins, such as sex and age, metabolism and their concentrations. (nutrition.org)
- Therefore, we measured the expression of key genes involved in oxylipins metabolism by qPCR on samples from stressed and non-stressed roots of a drought-tolerant and a drought-sensitive chickpea variety using commercially available TaqMan assays. (nih.gov)
- We conclude the altered metabolism in dyslipidemic subjects produces TGRL with a unique oxylipin signature that promotes a pro-atherogenic endothelial phenotype. (escholarship.org)
- Further web pages in this series explore the chemistry, biochemistry and function of the various types of oxylipin, although I am conscious that my approach may not adequately describe the true complexity of the interactions that occur in terms of metabolism and signalling or of physiological functions, especially the balance between different oxylipins and their pro- and anti-inflammatory effects. (lipidhome.co.uk)
- Four lipid entities differentiated high-contaminated from low-contaminated samples (cut-off of 2000 micrograms/Kg of fumonisins), confirming that sphingolipid and oxylipin metabolism in maize kernels interfere with F. verticillioides growth and fumonisin production. (unicatt.it)
Lipoxygenase7
- Possible mechanisms include competition between n -3 and n -6 PUFAs at the cyclooxygenase (COX) and lipoxygenase (LOX) and cytochrome P450 levels, and subsequent formation of oxylipins with specific anti-inflammatory or anti-arrhythmic effects. (mdpi.com)
- Observed changes in oxylipin levels can be connected to activation of cytochrome P450 (CYP) and 5-lipoxygenase (5-LOX) metabolic pathways in malaria infected individuals compared to controls, and related to increased levels of all linoleic acid oxylipins in severe patients compared to uncomplicated ones. (diva-portal.org)
- Accumulating data suggest that phase change and differentiation in these organisms are controlled by oxylipins, including prostaglandins and lipoxygenase products. (asm.org)
- Oxylipins, oxygenated derivatives of polyunsaturated fatty acids (PUFAs), are derived from PUFAs via cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 (CYP450), and nonenzymatic oxidation pathways (1,2). (spectroscopyonline.com)
- Downregulation of a lipoxygenase in the transcriptomic data and of its products in the metabolomic data also indicate an involvement of oxylipins. (nature.com)
- Thirty-seven oxylipins reflecting the cyclooxygenase (COX), lipoxygenase (5-LOX and 12/15-LOX), and cytochrome P450 (CYP) pathways were assayed in 197 cord blood plasma samples from the ENVIRONAGE birth cohort. (scilifelab.se)
- Lipoxygenase (LOX) enzymes and oxylipins play important roles in the defense reactions of virus-infected pepper and tobacco plants. (mtak.hu)
Pathways10
- Oxylipins constitute a family of oxygenated natural products which are formed from fatty acids by pathways involving at least one step of dioxygen-dependent oxidation. (wikipedia.org)
- Plants have evolved enzymatic pathways to facilitate the synthesis of particular oxylipin products, including several that are not synthesized by the chemical peroxidation reactions. (springer.com)
- Molecular pathways linking oxylipins to nociception in rats. (physiciansweekly.com)
- We further linked these pathways to nociception by demonstrating intraplantar carrageenan injection induced gene expression changes in oxylipin biosynthetic pathways. (physiciansweekly.com)
- We determined functional-biochemical relevance of the proposed pathways in rat hind paw and dorsal spinal cord by measuring basal and stimulated levels of oxylipins throughout the time-course of carrageenan-induced inflammation. (physiciansweekly.com)
- Finally, when oxylipins were administered by intradermal injection we observed modulation of nociceptive thermal hypersensitivity, providing a functional-behavioral link between oxylipins, their molecular biosynthetic pathways, and involvement in pain and nociception. (physiciansweekly.com)
- Together, these findings advance our understanding of molecular lipidomic systems linking oxylipins and their precursors to nociceptive and inflammatory signaling pathways in rats. (physiciansweekly.com)
- This systematic, quantitative evaluation of the molecular pathways linking oxylipins to nociception provides a framework for future basic and clinical research investigating the role of oxylipins in pain. (physiciansweekly.com)
- A broad range of pathogenic fungi, protozoa, and helminths produce eicosanoids and other oxylipins by novel synthesis pathways. (asm.org)
- 13-15 Considering the multitude and diversity of oxylipins as well as the different pathways involved in oxylipin formation the overall physiological effect might result rather from the general profile than from the levels of a single oxylipin. (rsc.org)
PUFA5
- Linoleic acid oxylipins are usually present in blood and tissue in higher concentrations than any other PUFA oxylipin, despite the fact that alpha-linolenic acid is more readily metabolized to oxylipin. (wikipedia.org)
- Some of the oxylipins elevated by DHA administration did not reflect the precursor PUFA consumed. (nutrition.org)
- In this study, we report the impact of routine long-term treatment with prescription-grade n -3 PUFA (either 840 mg or 1680 mg per day) on blood cell membrane fatty acid composition, as well as plasma oxylipin patterns, in a patient population with severe hyperlipidemia and cardiovascular disease who are on standard lipid-lowering and cardioprotective medications. (mdpi.com)
- Oxygenated polyunsaturated fatty acids (PUFA), i.e. eicosanoids and other oxylipins, are highly potent endogenous mediators of physiological and pathophysiological processes including regulation of endothelial function, blood pressure, thrombosis and inflammation. (rsc.org)
- however, feeding Fads2-/- mice MD restored both omega-3 PUFA and oxylipin profiles. (uoguelph.ca)
Mediators6
- Thus, eicosanoids and oxylipins (host or microbe) may be mediators of a direct host-pathogen "cross-talk" that promotes chronic infection and hypersensitivity disease, common features of infection by eukaryotic pathogens. (asm.org)
- Based on previous results, we have supporting data that oxylipin mediators of arachidonic acid, epoxyeicosatrienoic acid (EETs) play a major role in the attenuation of acute inflammatory response induced by tobacco smoke. (yes4yes.com)
- We will explore correlations to cells infiltration, blood pressure, proliferation and apoptosis along with pathological events, all with chronic exposure to tobacco smoke and oxylipin mediators. (yes4yes.com)
- Oxylipins are a superclass of lipid mediators with potent bioactivities in inflammation, vascular biology, and more. (elsevier.com)
- Oxylipins may be important mediators between early life exposures and health outcomes later in life. (scilifelab.se)
- Oxylipins, including the well-known eicosanoids, are potent lipid mediators involved in numerous physiological and pathological processes. (usda.gov)
Pathway7
- Aim of the present work was to clarify the potential impact of the phyto-oxylipins pathway on drought tolerance of chickpea (Cicer arietinum), the third important legume crop worldwide. (nih.gov)
- 2007). Ample evidence also implies that a fundamental role is played in plant immunity by the 9-LOX pathway-derived oxylipins. (europa.eu)
- Oxylipins of the 9-LOX pathway, like Hydroxyoctadecatrienoic acid (9-HOT), have been shown to accumulate after pathogen inoculation (Jalloul et al. (europa.eu)
- The objective of the project was to identify and functionally characterise genes involved in oxylipin signalling with a focus on the still elusive 9-LOX pathway. (europa.eu)
- The CYP450-oxylipin - soluble epoxide hydrolase (sEH) pathway is currently of great interest in targeting for cardiovascular disease. (sigmaaldrich.com)
- The characterization of mutants or transgenic plants affected in the biosynthesis or perception of oxylipins has recently emphasized the role of the so-called oxylipin pathway in plant defense against pests and pathogens. (plantphysiol.org)
- Other oxylipins, such as epoxy and dihydroxy fatty acids, can be formed from C18 PUFAs by the peroxygenase/epoxide hydrolase pathway ( Blée, 1998 ). (plantphysiol.org)
Formation of oxylipins3
- 9-Lipoxygenases ( 9-LOXs ) initiate fatty acid oxygenation, resulting in the formation of oxylipins activating plant defense against hemibiotrophic pathogenic bacteria. (plantphysiol.org)
- Dioxygenase genes with homology to mammalian prostaglandin synthase (PGS) have been connected to the formation of oxylipins in A. nidulans . (beds.ac.uk)
- 2013 Feb;161(2):617-27 Vellosillo T, Aguilera V, Marcos R, Bartsch M, Vicente J, Cascón T, Hamberg M, Castresana C . 9-Lipoxygenases ( 9-LOXs ) initiate fatty acid oxygenation, resulting in the formation of oxylipins activating plant. (csic.es)
Biosynthesis3
- Monooxygenases involved in oxylipin biosynthesis are members of the cytochrome P450 superfamily and can oxidize double bonds with epoxide formation or saturated carbons forming alcohols. (wikipedia.org)
- We applied a systems-based approach to characterize oxylipin precursor fatty acids, and expression of genes coding for proteins involved in biosynthesis, transport, signaling and inactivation of pro- and anti-nociceptive oxylipins in pain circuit tissues. (physiciansweekly.com)
- Transcriptomic analysis of oxylipin biosynthesis genes and chemical profiling reveal an early induction of jasmonates in chickpea roots under droug. (nih.gov)
Anti-inflammatory6
- Linoleic acid oxylipins can be anti-inflammatory, but are more often pro-inflammatory, associated with atherosclerosis, non-alcoholic fatty liver disease, and Alzheimer's disease. (wikipedia.org)
- The omega-3 eicosapentaenoic acid (EPA)-derived and docosahexaenoic acid (DHA)-derived oxylipins are anti-inflammatory and vasodilatory. (wikipedia.org)
- Intimal smooth muscle cells are a source but not a sensor of anti-inflammatory CYP450 derived oxylipins. (sigmaaldrich.com)
- iSMCs are a rich source but not a sensor of anti-inflammatory epoxy-oxylipins. (sigmaaldrich.com)
- Dysregulation of oxylipin formation is implicated among others in cardiovascular, immune or metabolic diseases 11,12 and several pharmaceuticals act by modulating the oxylipin profile ( e.g. non-steroidal anti-inflammatory drugs, anti-thrombotic drugs, the asthma drug zileuton). (rsc.org)
- Falcarinol (FaOH) and falcarindiol (FaDOH) are cytotoxic and anti-inflammatory polyacetylenic oxylipins, which are commonly found in the carrot family (Apiaceae). (aau.dk)
Natural Oxylipins2
- The main object of the Laboratory's research is natural oxylipins (prostaglandins, etc.), natural neurolypes (conjugates of fatty acids with biogenic amines, neurotransmitters and amino acids) and their synthetic analogues. (ibch.ru)
- To get a better insight into the biological activities of oxylipins, in vitro growth inhibition assays were used to investigate the direct antimicrobial activities of 43 natural oxylipins against a set of 13 plant pathogenic microorganisms including bacteria, oomycetes, and fungi. (plantphysiol.org)
Endocannabinoids1
- Methods: Detection of oxylipins and endocannabinoids from plasma samples from forty children with uncomplicated and severe malaria as well as twenty controls was done after solid phase extraction followed by chromatography mass spectrometry analysis. (diva-portal.org)
Eicosanoids and Related Oxylipins1
- Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins. (harvard.edu)
Acids19
- Practical guidelines for monitoring and measuring compounds such as jasmonates, ketols, ketodi(tri)enes and hydroxy-fatty acids as well as detecting the presence of novel oxylipins are presented. (nih.gov)
- Oxylipins are derived from polyunsaturated fatty acids (PUFAs) by COX enzymes (cyclooxygenases), by LOX enzymes (lipoxygenases), or by cytochrome P450 epoxygenase. (wikipedia.org)
- Typically, oxylipins are not stored in tissues but are formed on demand by liberation of precursor fatty acids from esterified forms. (wikipedia.org)
- In the plant and animal kingdoms the C18 and C20 polyenoic fatty acids, respectively, are the major precursors of oxylipins. (wikipedia.org)
- In general, oxylipins derived from omega-6 fatty acids are more pro-inflammatory, vasconstrictive, and proliferative than those derived from omega-3 fatty acids. (wikipedia.org)
- Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study. (harvard.edu)
- Among the upregulated oxylipins, hydroxylated eicosapentaenoic acids (HEPEs) dominate. (mdpi.com)
- Sex differences in the plasma accumulation of oxylipins in response to supplemental n-3 fatty acids. (nutrition.org)
- Effects of oxylipins depend on tissue-specific differences in accumulation of precursor polyunsaturated fatty acids and the expression of specific enzymes to transform the precursors. (physiciansweekly.com)
- Concentrations of esterified and non-esterified fatty acids and oxylipins in TGRL were quantified by mass spectrometry. (escholarship.org)
- Oxylipins are so numerous and have such a range of biological activities that they must provide a substantial component of the reason for the essentiality these polyunsaturated fatty acids to the survival and well-being of animals. (lipidhome.co.uk)
- Oxylipins, which derive from the oxygenation of unsaturated fatty acids, comprise a multiplicity of various signal compounds in animals and plants. (brainkart.com)
- While 3-hydroxy (OH) oxylipins, a class of hydroxy free fatty acids (FFA), have been previously presumed to play a role in the industrially important brewing yeast flocculation phenomenon, the exact biological function was not known. (dal.ca)
- In this context, the international journal Redox Biology has recently published a graphical review article entitled Oxylipins in plastidial retrograde signaling by our ANTIOX members Dr. Paula Muñoz and Prof. Sergi Munné-Bosch , where they highlight the relevant role of these compounds derived from the oxidation of polyunsaturated fatty acids in plastidial retrograde signaling to highlight future avenues for research . (antiox-postharvest.com)
- Our objective was to compare the oxylipin composition of VLDL, LDL, and HDL in 14 optimally healthy individuals and 31 MetSyn patients, and then to determine the effects of treating MetSyn subjects with 4 g/day of prescription omega-3 fatty acids (P-OM3) on lipoprotein oxylipin profiles. (elsevier.com)
- We conclude that MetSyn is associated with a disruption of lipoprotein oxylipin patterns consistent with greater inflammatory stress, and the partial correction of these dysoxylipinemias by treatment with omega-3 fatty acids could explain some of their beneficial effects. (elsevier.com)
- As part of the lipidome, oxylipins are bioactive lipid compounds originating from oxidation of different fatty acids. (scilifelab.se)
- Eicosanoids are a sub-category of oxylipins , i.e. oxidized fatty acids of diverse carbon units in length, and are distinguished from other oxylipins by their overwhelming importance as cell signaling molecules. (wikipedia.org)
- Oxylipins are routinely made in the body from polyunsaturated fatty acids, and they include what are called the "omega-3 oxylipins" made from omega-3 fatty acids like alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). (whfoods.com)
Prostaglandins5
- Eicosanoids are a subset of oxylipins and include the prostaglandins and leukotrienes, which are potent regulators of host immune responses. (asm.org)
- One of the most biologically important groups of oxylipins in mammals is the eicosanoids, which include prostaglandins and leukotrienes. (asm.org)
- Descriptions of eicosanoid and oxylipin production by eukaryotic microbes have been scattered through the literature for decades, but they have begun to receive significant attention in the last few years following reports of prostaglandins and prostaglandin-like molecules being produced by pathogenic helminths, protozoa, and fungi. (asm.org)
- In the present study, we examined whether particular urinary oxylipins (isoprostanes (IsoPs), leukotrienes (LTs), prostaglandins (PGs), and thromboxanes (TXs)) in 16 elite triathletes could alter during 145 days of training. (rsc.org)
- In animals, oxylipins include prostaglandins, leucotriens, and thrombox-ans, of which the specific roles in the regulation of physiological processes are known to a large extent. (brainkart.com)
PUFAs1
- Oxygenated derivates of PUFAs, or oxylipins, are formed from multiple enzymatic reactions, and oxylipins have multiple biological activities related to inflammation and immune function, for example. (nutrition.org)
Inflammation5
- Oxylipins in triglyceride-rich lipoproteins of dyslipidemic subjects promote endothelial inflammation following a high fat meal. (escholarship.org)
- While their role as locally produced agents is appreciated, most oxylipins in plasma are found in lipoproteins suggesting defective regulation of inflammation could be mediated by the elevated VLDL and low HDL levels characteristic of MetSyn. (elsevier.com)
- In patients with hypertension and peripheral artery disease, flaxseed consumption for 1 year significantly decreased plasma oxylipins that are responsible for propagating inflammation and vascular constriction. (umanitoba.ca)
- Although decreased risk of oxidative stress and chronic inflammation in the blood vessels has previously been shown to be a welcomed result of onion intake, this recent research on oxylipins may lead to a better understanding of onions and their unique health benefits. (whfoods.com)
- N -Acyletanolaminer (NAE) är en familj av lipider i kroppen som kan agera som en försvarsmekanism genom att exempelvis motverkar inflammation. (umu.se)
Compounds7
- The oxylipin compounds produced, including reactive electrophile species (RES), contribute to the induction of defense-gene expression and also act directly in defense against insects and microbes. (springer.com)
- Six oxylipins strongly inhibited mycelial growth and spore germination of eukaryotic microbes, including compounds that had not previously been ascribed an antimicrobial activity, such as 13-keto-9( Z ),11( E ),15( Z )-octadecatrienoic acid and 12-oxo-10,15( Z )-phytodienoic acid. (plantphysiol.org)
- The extracted compounds were then analyzed by ultra-high-performance liquid chromatography electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS) via targeted comparative metabolomics for the profiling of 51 bioactive LCFAs and oxylipins. (spectroscopyonline.com)
- These results implicate a new class of compounds in diet-induced obesity-C18 epoxide and diol oxylipins. (elsevier.com)
- Likewise, plant oxylipins comprise a very large number of compounds mostly different from those in animals. (brainkart.com)
- These results showed that beside oxylipins also terpenoid compounds accumulated in pepper leaves following virus infections. (mtak.hu)
- Jasmonic acid and other fatty‐acid‐derived compounds called oxylipins are signals in stress responses and development of plants. (els.net)
Eicosanoid2
- Here, we show that the diatom Chaetoceros didymus releases eicosanoid oxylipins into the medium, and that the lytic algicidal bacterium, Kordia algicida , induces the production of several wound-activated oxylipins in this resistant diatom. (mdpi.com)
- Also, the mechanism for catabolism of oxylipins is common to most eicosanoid classes and for convenience is discussed below. (lipidhome.co.uk)
Jasmonic1
- 2005). The best-characterised oxylipin is jasmonic acid (JA) with its well-defined role in developmental and defence signalling (Turner et al. (europa.eu)
Omega-3 oxylipins1
- Consumption of onions has been shown to increase the levels of omega-3 oxylipins in the liver, and this increase in omega-3 oxylipins may help explain the ability of onions to help regulate proper blood fat levels as well as blood levels of cholesterol. (whfoods.com)
Analysis of oxylipins1
- Quantitative analysis of oxylipins in blood samples is of increasing interest in clinical studies. (rsc.org)
Functions of Oxylipins1
- In this context, presumed functions of oxylipins include direct antimicrobial effect, stimulation of plant defense gene expression, and regulation of plant cell death. (plantphysiol.org)
Production of oxylipins1
- In the mentioned review, our ANTIOX members emphasize plastid diversity regarding developmental stage, plant organ or stressful conditions, where the production of oxylipins might be affected and become intermediate signals or hormonal elicitors to facilitate acclimation or developmental responses. (antiox-postharvest.com)
Defense6
- The oxylipin production may represent an independent line of defense of the resistant alga, acting in addition to the previously reported upregulation of proteases. (mdpi.com)
- Blée E (2002) Impact of phyto-oxylipins in plant defense. (springer.com)
- Previous studies using nonresponding to oxylipins ( noxy ), a series of Arabidopsis ( Arabidopsis thaliana ) mutants insensitive to the 9-LOX product 9-hydroxy-10,12,15-octadecatrienoic acid ( 9-HOT ), have demonstrated the importance of cell wall modifications as a component of 9-LOX -induced defense. (plantphysiol.org)
- However, the precise contribution of individual oxylipins to plant defense remains essentially unknown. (plantphysiol.org)
- Interestingly, this first large-scale comparative assessment of the antimicrobial effects of oxylipins reveals that regulators of plant defense responses are also the most active oxylipins against eukaryotic microorganisms, suggesting that such oxylipins might contribute to plant defense through their effects both on the plant and on pathogens, possibly through related mechanisms. (plantphysiol.org)
- Based on our results we propose that under K-deficiency plants produce oxylipins and glucosinolates to enhance their defense potential against herbivorous insects and create reversible storage for excess S and N. (biomedcentral.com)
Biological8
- Nature has evolved numerous enzymes which metabolize oxylipins into secondary products, many of which possess strong biological activity. (wikipedia.org)
- Existing methods for the analysis of LCFAs and oxylipins have limited compound coverage and sensitivity that, therefore, prevent their application in biological studies. (spectroscopyonline.com)
- LCFAs and oxylipins were first extracted from biological samples via solid-phase extraction. (spectroscopyonline.com)
- Considering the biological roles of LCFAs and oxylipins, the developed method could become an essential method in nutritional and clinical research. (spectroscopyonline.com)
- The biological roles of oxylipins have been extensively studied in animals, plants, algae and fungi, but remain largely unidentified in prokaryotes. (uab.edu)
- While unesterified oxylipins are of primary importance, it is becoming evident that some esterified forms may have biological activity also. (lipidhome.co.uk)
- To maximize the utility of oxylipin profiling in clinical research, it is crucial to better understand and assess the factors contributing to the analytical and biological variability of oxylipin profiles in humans. (usda.gov)
- In this review, these factors and their impacts are summarized and discussed, providing a framework for recommendations expected to enhance the interlaboratory comparability and biological interpretation of oxylipins profiling in clinical research. (usda.gov)
Produce oxylipins2
- Why do these organisms produce oxylipins? (asm.org)
- Using diverse sources to present a model of why these microbes produce oxylipins, we will also present evidence that these microbial oxylipins may play a significant role in a host-pathogen "cross-talk" that contributes to chronic infection. (asm.org)
Different oxylipins1
- 2007). Among the different oxylipins (9-LOX- and 13-LOX-derived) tested, the 9-LOX derivate 9-HOT was shown to be one of the most potent inducers of a characteristic root waving phenotype as well as an inhibitor of lateral root formation. (europa.eu)
Plants4
- Oxylipins are widespread in aerobic organisms including plants, animals and fungi. (wikipedia.org)
- This increase in LOX5 expression is paralleled by an increase in LOX5-synthesized oxylipins in the root and petiole exudates of GPA-infested plants. (unt.edu)
- Browse J (2005) Jasmonate: An oxylipin signal with many roles in plants. (springer.com)
- In plants, oxylipins are synthesized primarily via lipoxygenases . (brainkart.com)
Synthesis1
- Oxylipin synthesis is triggered by various biotic and abiotic stresses as well as also taking place during specific developmental stages (Howe and Schilmiller, 2002). (europa.eu)
Lipoxygenases1
- Polyunsaturated NAEs can also be oxidised to NAE‐oxylipins via lipoxygenases (LOX). (els.net)
Regulate4
- It is known that oxylipins regulate gene expression, impact plant cell death and display direct antimicrobial activity (Almeras et al. (europa.eu)
- Oxylipins, oxygenated derivatives of LCFAs, regulate the activity of many cellular processes. (spectroscopyonline.com)
- Oxylipins regulate Aspergillus development and mycotoxin production and are also involved in Aspergillus quorum sensing mechanisms. (beds.ac.uk)
- Despite extensive knowledge of how these oxylipins are synthesized and what processes they regulate, nothing is known about how these signals are detected and transmitted by the fungus. (beds.ac.uk)
Pathogens3
- Plant oxylipins are mainly involved in control of ontogenesis, reproductive processes and in the resistance to various microbial pathogens and other pests. (wikipedia.org)
- Perform an in-depth phenotypic analysis of the NOXY mutants and the transgenic NOXY over-expressing Arabidopsis lines, with a focus on testing their resistance to biotrophic and necrotrophic pathogens, and testing their responsiveness to various oxylipins. (europa.eu)
- This study showed unequivocally that most oxylipins are able to impair growth of some plant microbial pathogens, with only two out of 43 oxylipins being completely inactive against all the tested organisms, and 26 oxylipins showing inhibitory activity toward at least three different microbes. (plantphysiol.org)
Concentrations3
- In order to explore these determinants further, Gabbs and colleagues conducted a study using ALA and DHA-rich supplements to determine the effect of time course and sex on plasma oxylipin concentrations. (nutrition.org)
- Even though ALA supplementation led to elevated plasma ALA concentrations, it did not affect the levels of ALA oxylipins after 28 days. (nutrition.org)
- Healthy older adults, who consumed flaxseed every day for 4 weeks, exhibited significantly decreased concentrations of plasma pro-inflammatory oxylipins such as 5-hydroxyeicosatetraenoic acid and trihydroxyoctadecenoic acid. (umanitoba.ca)
Quantification2
- Additional information on oxylipin quantification and novel protocols for preparing oxygen isotope-labelled internal standards are provided. (nih.gov)
- 16,17 Therefore, comprehensive and reliable quantification of the oxylipin pattern may be valuable to evaluate the disease state or monitor the action of drugs. (rsc.org)
Fatty acid3
- Modulation of the endogenous omega-3 fatty acid and oxylipin profile in vivo-A comparison of the fat-1 transgenic mouse with C57BL/6 wildtype mice on an omega-3 fatty acid enriched diet. (physiciansweekly.com)
- In order to assess their power to modulate the fatty acid and oxylipin pattern, we thoroughly compared fat-1 and wild-type C57BL/6 mice on a sunflower oil diet with wild-type mice on the same diet enriched with 1% EPA and 1% DHA for 0, 7, 14, 30 and 45 days. (physiciansweekly.com)
- Spleen Oxylipin and Polyunsaturated Fatty Acid Profiles are Altered by Dietary Source of Polyunsaturated Fatty Acid and by Sex. (flaxresearch.com)
Derivatives3
- The purpose of our study was to quantify changes in N -acylethanolamine species and their oxylipin derivatives in the retina of a mouse model for glaucoma and to identify relationships among changes of these signaling molecules and of parameters of glaucoma disease development. (arvojournals.org)
- Levels of five N- acylethanolamine species and three NAE oxylipin derivatives were quantified in the retinae of 1.5 (healthy) and 8.5 month-old (glaucomatous) DBA/2Crl mice and correlated with intraocular pressure (IOP) measured by rebound tonometry, visual acuity and contrast sensitivity determined behaviorally assessing optomotor responses to stimuli of varying contrast or spatial frequency. (arvojournals.org)
- Detection of the heptafluorobuyrate methyl ester derivatives using negative chemical ionization-mass spectrometry allowed for the first quantitative analysis of 3-OH oxylipins in yeast. (dal.ca)
Phenotype1
- The fact that the application of 9-HOT induces a prominent root-waving phenotype was used to identify approximately 70 9-HOT insensitive mutants (non-responding to oxylipins, NOXY) within a mutagenised A. thaliana population (Vellosillo et al. (europa.eu)
Enzymatic3
- however also non-enzymatic autoxidative processes contribute to oxylipin formation (phytoprostanes, isoprostanes). (wikipedia.org)
- However, storage after sampling and transport of blood might induce artificial changes in the apparent oxylipin profile due to ex vivo formation/degradation by autoxidation or enzymatic activity. (rsc.org)
- Different analytical methods, such as radiometric and enzymatic immunoassays, have been developed to analyze LCFAs and oxylipins (6-8). (spectroscopyonline.com)
CYP4501
- iSMC basally released significantly larger amounts of epoxy-oxylipin CYP450 products from eicosapentaenoic acidxa0>xa0docosahexaenoic acidxa0>xa0arachidonic acidxa0>xa0linoleic acid, and expressed higher levels of CYP2C12, CYP2B1, but not CYP2J mRNA compared to mSMC. (sigmaaldrich.com)
Metabolomics2
- The objective of this study was to develop a liquid chromatography-mass spectrometry (LC-MS) method to simultaneously quantify a large number of LCFAs and oxylipins via targeted comparative metabolomics (10). (spectroscopyonline.com)
- Comparative TNBC proteomics using the same tissue specimens subjected to oxylipin metabolomics analysis was used as validation set. (springer.com)
Plasma5
- In contrast, DHA supplements led to an increase in both plasma DHA and DHA oxylipins. (nutrition.org)
- Time course and sex difference patterns in plasma EPA and EPA oxylipins were similar with DHA supplementation. (nutrition.org)
- Time course and sex effects of a-linolenic acid-rich and DHA-rich supplements on human plasma oxylipins: A randomized double-blind crossover trial. (nutrition.org)
- Overall, our results indicate that total EDTA-plasma oxylipins are the most stable blood oxylipin marker for clinical samples. (rsc.org)
- Every 1 nM increase in plasma 16-hydroxyeicosatetraenoic acid increased the odds of a stroke by 55-fold, thus indicating the potential of particular oxylipins to act as diagnostic markers or therapeutic targets. (umanitoba.ca)
Endogenous1
- Under the proposed objectives we first examine the efficacy of EETs in chronic inflammatory model induced by tobacco smoke, followed by measuring endogenous levels of oxylipin and examining the cardio-pulmonary pathological endpoints associated with these exposure conditions. (yes4yes.com)
Eicosapentaenoic1
- Humans carrying genetic variants in the FADS2 gene have reduced levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as oxylipins, in blood, erythrocytes and white adipose tissue (WAT). (illinois.edu)
Profiles6
- This graph shows the total number of publications written about "Oxylipins" by people in Harvard Catalyst Profiles by year, and whether "Oxylipins" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Oxylipins" by people in Profiles. (harvard.edu)
- TOF-SIMS analysis also showed a compositional difference at the interior and exterior of fermenting and respiring cells, while immunofluorescence results suggested contrasting 3-OH oxylipin profiles in fermenting vs. respiring SMA cells. (dal.ca)
- 2.5 μm) exposure and oxylipin profiles in newborns. (scilifelab.se)
- Volatile blends and oxylipins profiles in potato leaves (Solanum tuberosum L.) exposed to insects infestations and mechanical wounding. (uliege.be)
- Reference : Volatile blends and oxylipins profiles in potato leaves (Solanum tuberosum L.) expose. (uliege.be)
Acid5
- Most oxylipins in the body are derived from linoleic acid or alpha-linolenic acid. (wikipedia.org)
- Centenarians have shown reduced levels of linoleic acid oxylipins in their blood circulation. (wikipedia.org)
- Lowering dietary linoleic acid results in fewer linoleic acid oxylipins in humans. (wikipedia.org)
- In addition, acetylsalicylic acid was found to inhibit the production of 3-OH oxylipins by probably decreasing mitochondrial activity resulting in the inhibition of ascospore release. (ufs.ac.za)
- Similarly, plant products such as the jasmonates and other oxylipins derived from 9 c ,12 c ,15 c -octadecatrienoic (α-linolenic or 18:3( n ‑3)) acid have some comparable structural features and functions. (lipidhome.co.uk)
Sigma-Aldrich1
- LCFA and oxylipin standards were purchased from Cayman Chemicals and Sigma-Aldrich. (spectroscopyonline.com)
Signal transduction1
- The review article also describes the latest knowledge related to signal transduction of reactive electrophilic species as secondary lipid peroxidation products which have been long overlooked when describing oxylipin-related signal transduction and the problems associated with the study and interpretation of the production of these molecules in plant cells. (antiox-postharvest.com)
Eukaryotic microbes1
- This review will focus on the potential of oxylipins as secreted virulence factors not in the same context as microbial toxins but rather as factors required for virulence that augment other virulence mechanisms of pathogenic eukaryotic microbes. (asm.org)
Microbial1
- The study of microbial oxylipins in disease pathogenesis is just beginning. (asm.org)
Genes2
- A. niger produces the same oxylipins and has similar dioxygenase genes as A. nidulans . (beds.ac.uk)
- The goal of this study was to investigate whether or not oxylipins and dioxygenase genes related to sexual reproduction are also present in the asexual fungus A. niger . (beds.ac.uk)