A compound formed by the combination of hemoglobin and oxygen. It is a complex in which the oxygen is bound directly to the iron without causing a change from the ferrous to the ferric state.
An increase in circulating RETICULOCYTES, which is among the simplest and most reliable signs of accelerated ERYTHROCYTE production. Reticulocytosis occurs during active BLOOD regeneration (stimulation of red bone marrow) and in certain types of ANEMIA, particularly CONGENITAL HEMOLYTIC ANEMIA.
Application of principles and practices of engineering science to biomedical research and health care.
The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A nursing specialty concerned with the care provided to cancer patients. It includes aspects of family functioning through education of both patient and family.
A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.
Schools which offer training in the area of health.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Pathological processes involving any part of the LUNG.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)
An alternative to amputation in patients with neoplasms, ischemia, fractures, and other limb-threatening conditions. Generally, sophisticated surgical procedures such as vascular surgery and reconstruction are used to salvage diseased limbs.
The inferior part of the lower extremity between the KNEE and the ANKLE.
Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
Pressure within the cranial cavity. It is influenced by brain mass, the circulatory system, CSF dynamics, and skull rigidity.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Manometric pressure of the CEREBROSPINAL FLUID as measured by lumbar, cerebroventricular, or cisternal puncture. Within the cranial cavity it is called INTRACRANIAL PRESSURE.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The processes whereby the internal environment of an organism tends to remain balanced and stable.
A group of recessively inherited diseases that feature progressive muscular atrophy and hypotonia. They are classified as type I (Werdnig-Hoffman disease), type II (intermediate form), and type III (Kugelberg-Welander disease). Type I is fatal in infancy, type II has a late infantile onset and is associated with survival into the second or third decade. Type III has its onset in childhood, and is slowly progressive. (J Med Genet 1996 Apr:33(4):281-3)
A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)
A SMN complex protein that is essential for the function of the SMN protein complex. In humans the protein is encoded by a single gene found near the inversion telomere of a large inverted region of CHROMOSOME 5. Mutations in the gene coding for survival of motor neuron 1 protein may result in SPINAL MUSCULAR ATROPHIES OF CHILDHOOD.
A complex of proteins that assemble the SNRNP CORE PROTEINS into a core structure that surrounds a highly conserved RNA sequence found in SMALL NUCLEAR RNA. They are found localized in the GEMINI OF COILED BODIES and in the CYTOPLASM. The SMN complex is named after the Survival of Motor Neuron Complex Protein 1, which is a critical component of the complex.
A SMN complex protein that is closely-related to SURVIVAL OF MOTOR NEURON 1 PROTEIN. In humans, the protein is encoded by an often duplicated gene found near the inversion centromere of a large inverted region of CHROMOSOME 5.
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.
An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.
A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
A superfamily of proteins containing the globin fold which is composed of 6-8 alpha helices arranged in a characterstic HEME enclosing structure.
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Substances that are used in place of blood, for example, as an alternative to BLOOD TRANSFUSIONS after blood loss to restore BLOOD VOLUME and oxygen-carrying capacity to the blood circulation, or to perfuse isolated organs.

Aggregation of deoxyhemoglobin S at low concentrations. (1/1078)

The self-association of deoxyhemoglobin S was measured in dilute solutions (0 to 5 g/dl) by Rayleigh light scattering at 630 nm and osmometry in 0.05 M potassium phosphate buffer (pH 7.35). Weight and number average molecular weights (Mw and Mn, respectively) and the second or higher virial coefficients, B' were determined. No experimentally significant differences were observed between oxy- and deoxy-Hb S up to the concentration of 2 g/dl; their apparent average molecular weights were within experimental error. Above that concentration, both Mn and Mw of deoxy-Hb S were significantly different from that of oxy-Hb S. The negative second viral coefficent of deoxy-Hb S, observed by both techniques, is consistent with the self-association of this protein. The lack of effect of 0.4 M propylurea on the state of aggregation and the significant influence of 0.1 M NaCl suggests that polar interactions are involved in formation of these aggregates.  (+info)

Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements. (2/1078)

Despite the possibility that tumour hypoxia may limit radiotherapeutic response, the underlying mechanisms remain poorly understood. A new methodology has been developed in which information from several sophisticated techniques is combined and analysed at a microregional level. First, tumour oxygen availability is spatially defined by measuring intravascular blood oxygen saturations (HbO2) cryospectrophotometrically in frozen tumour blocks. Second, hypoxic development is quantified in adjacent sections using immunohistochemical detection of a fluorescently conjugated monoclonal antibody (ELK3-51) to a nitroheterocyclic hypoxia marker (EF5), thereby providing information relating to both the oxygen consumption rates and the effective oxygen diffusion distances. Third, a combination of fluorescent (Hoechst 33342 or DiOC7(3)) and immunohistological (PECAM-1/CD31) stains is used to define the anatomical vascular densities and the fraction of blood vessels containing flow. Using a computer-interfaced microscope stage, image analysis software and a 3-CCD colour video camera, multiple images are digitized, combined to form a photo-montage and revisited after each of the three staining protocols. By applying image registration techniques, the spatial distribution of HbO2 saturations is matched to corresponding hypoxic marker intensities in adjacent sections. This permits vascular configuration to be related to oxygen availability and allows the hypoxic marker intensities to be quantitated in situ.  (+info)

In vitro simultaneous measurements of relaxation and nitric oxide concentration in rat superior mesenteric artery. (3/1078)

1. The relationship between nitric oxide (NO) concentration measured with an NO-specific microelectrode and endothelium-dependent relaxation was investigated in isolated rat superior mesenteric artery contracted with 1 microM noradrenaline. 2. Acetylcholine (10 microM) induced endothelium-dependent simultaneous increases in luminal NO concentration of 21 +/- 6 nM, and relaxations with pD2 values and maximum of 6.95 +/- 0.32 and 97.5 +/- 0.7 % (n = 7), respectively. An inhibitor of NO synthase, N G-nitro-L-arginine (L-NOARG, 100 microM) inhibited the relaxations and increases in NO concentration induced by acetylcholine. 3. Oxyhaemoglobin (10 microM) reversed the relaxations and increases in NO concentrations induced by acetylcholine, S-nitroso-N-acetylpenicillamine (SNAP) and S-morpholino-sydnonimine (SIN-1), but not the relaxations induced with forskolin. Oxyhaemoglobin also decreased the NO concentration below baseline level. 4. In the presence of L-NOARG (100 microM), a small relaxation to acetylcholine (10 microM) of noradrenaline-contracted segments was still seen; oxyhaemogobin inhibited this relaxation and decreased the NO concentration by 14 +/- 4 nM (n = 4). 5. The NO concentration-relaxation relationship for acetylcholine resembled that for SNAP and SIN-1 more than for authentic NO. Thus while 7-17 nM NO induced half-maximal relaxations in response to SNAP or SIN-1, 378 +/- 129 nM NO (n = 4) was needed for half-maximal relaxation to authentic NO. 6. The present study provides direct evidence that the relaxation of the rat superior mesenteric artery with the endothelium-dependent vasodilator acetylcholine is correlated to the endogeneous release of NO. The study also suggests that NO mediates the L-NOARG-resistant relaxations in this artery, and that there is a basal NO release.  (+info)

RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H mice. (4/1078)

Pre-clinical evaluation has demonstrated that 2-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]-2-methylpropi onic acid (RSR13) acts as an allosteric effector of haemoglobin (Hb). RSR13 binding to Hb results in decreased haemoglobin-oxygen (Hb-O2) affinity, improved tumour oxygenation, and enhanced radiation-induced cell killing in several experimental tumour systems. In the present work, ex vivo clonogenic survival analyses are applied in two murine tumour systems to characterize the relationship between the magnitude of decrease in Hb-O2 affinity and radiosensitization, the influence of inspired pO2 upon this effect, and the efficacy of combining RSR13 and radiation during a course of repeated radiation exposures. For FSaII tumours in C3H mice breathing air, 100 mg kg(-1) RSR13 administered intraperitoneally produced an enhancement ratio (ER) of 1.3, but there was marked desensitization at a RSR13 dose of 300 mg kg(-1) (ER 0.6). The most likely reason for the increased radioresistance was insufficient oxygen loading of Hb in the pulmonary circulation due to reduced haemoglobin-oxygen affinity because carbogen breathing combined with 300 mg kg(-1) RSR13 reversed the effect and produced an ER of 1.8. In SCCVII tumours in C3H mice irradiated with eight fractions of 2.5 Gy over 4 days, the surviving fraction was reduced to 58-67% of control values when RSR13 was combined with radiation on days 1 and 2, days 3 and 4, or days 1-4. These results confirm that combining RSR13 and irradiation within a fractionated course of clinically relevant low-dose exposures provides significant radiosensitization. Additional preclinical experimentation is needed to define better the optimum dose-scheduling conditions for clinical applications.  (+info)

Analysis of optical signals evoked by peripheral nerve stimulation in rat somatosensory cortex: dynamic changes in hemoglobin concentration and oxygenation. (5/1078)

The origins of reflected light changes associated with neuronal activity (optical signals) were investigated in rat somatosensory cortex with optical imaging, microspectrophotometry, and laser-Doppler flowmetry, and dynamic changes in local hemoglobin concentration and oxygenation were focused on. Functional activation was carried out by 2-second, 5-Hz electrical stimulation of the hind limb under chloralose anesthesia. These measurements were performed at the contralateral parietal cortex through a thinned skull. Regional cortical blood flow (rCBF) started to rise 1.5 seconds after the stimulus onset, peaked at 3.5 seconds (26.7% +/- 9.7% increase over baseline), and returned to near baseline by 10 seconds. Optical signal responses at 577, 586, and 805 nm showed a monophasic increase in absorbance coincident with the increase in rCBF; however, the signal responses at 605 and 760 nm were biphasic (an early increase and late decrease in absorbance) and microanatomically heterogeneous. The spectral changes of absorbance indicated that the concentrations of both total hemoglobin and oxyhemoglobin increased together with rCBF; deoxyhemoglobin, increased slightly but distinctly (P = 0.016 at 1.0 seconds, P = 0.00038 at 1.5 seconds) just before rCBF increases, then decreased. The authors conclude that activity-related optical signals are greatly associated with a moment-to-moment adjustment of rCBF and metabolism to neuronal activity.  (+info)

Early occurrence of respiratory muscle deoxygenation assessed by near-infrared spectroscopy during leg exercise in patients with chronic heart failure. (6/1078)

The mechanisms of respiratory muscle deoxygenation during incremental leg exercise with expired gas analysis were investigated in 29 patients with chronic heart failure and 21 normal subjects. The deoxygenation and blood volume of the respiratory muscle and exercising leg muscle were assessed by near-infrared spectroscopy (NIRS). To evaluate the influence of the leg exercise on the blood volume of the respiratory muscle, 10 normal subjects also underwent a hyperventilation test with NIRS. The respiratory muscle deoxygenation point (RDP), at which oxygenated hemoglobin starts to decrease, was observed in both groups during exercise. The oxygen consumption (VO2) and the minute ventilation at the RDP in the patients was lower (p<0.01). At the same VO2, the respiratory rate was higher in patients (p<0.01). During exercise, the blood volume of the leg muscle increased, while that of the respiratory muscle decreased. During a hyperventilation test, the minute ventilation was higher than that of the RDP during exercise, the blood volume of the respiratory muscle did not decrease, and the RDP was not detectable. In conclusion, a limited ability to increase perfusion of respiratory muscles during exercise combined with the greater work of breathing results in early respiratory muscle deoxygenation in patients with chronic heart failure.  (+info)

Functional differentiation in trematode hemoglobin isoforms. (7/1078)

The Hbs and the major electrophoretic Hb components (isoHbs) were isolated from three species of the trematodes, Explanatum explanatum (Ee), Gastrothylax crumenifer (Gc) and Paramphistomum epiclitum (Pe), that parasitise the common Indian water buffalo Bubalus bubalis. The Hbs are monomeric and resemble the so-called nonfunctional mutant hemoglobins that have Tyr at B10 or E7 positions (replacing Leu and the His residues, respectively). However, they are capable of binding with O2 and CO. O2 equilibrium studies of trematode Hb isoforms reveal extremely high O2 affinities, with half-saturation O2 tension (P50) values up to 800 times lower than those of human hemoglobins. This correlates with Tyr residues at B10 and at the distal position (E7) that decrease the O2 dissociation rate by contributing hydrogen bonds (H-bonds) to the bound O2. These substitutions also increase the O2 association rates either due to orientation of E7-Tyr towards the solvent and/or by sterically hindering the entry of water molecules into the heme pocket. The latter may account for the low rate of autoxidation of trematode Hbs. The Hbs and their isoforms from different species exhibited pronounced variation in O2 affinity, which may relate to subtle differences in the structure of the heme pocket. The O2 affinities of the composite (unfractionated) Hbs were intermediate to those of the individual Hb isoform. The P50 values of Hbs here obtained by direct O2 equilibrium measurements differed from those calculated from kinetic data already published [Kiger, L., Rashid, A. K., Griffon, N., Haque, M., Moens, L.,Gibson, Q. H., Poyart, C., & Marden, M. C. (1998). Biophys. J. 75, 990-998.] Intermediate state(s) due to slow reorientation of E7-Tyr may account for this difference. Some Hb isoforms showed slight (either normal or reverse) Bohr effects. The hyperbolic O2 equilibrium curve, Hill coefficient (n) values near unity accord with a monomeric nature of trematode Hbs. In marked contrast to vertebrate Hbs, CO does not seem to compete effectively with O2 in trematode Hbs, as evident from partition coefficient values (M) below 1.  (+info)

Effect of chronic sodium cyanate administration on O2 transport and uptake in hypoxic and normoxic exercise. (8/1078)

Systemic O2 transport during maximal exercise at different inspired PO2 (PIO2) values was studied in sodium cyanate-treated (CY) and nontreated (NT) rats. CY rats exhibited increased O2 affinity of Hb (exercise O2 half-saturation pressure of Hb = 27.5 vs. 42.5 Torr), elevated blood Hb concentration, pulmonary hypertension, blunted hypoxic pulmonary vasoconstriction, and normal ventilatory response to exercise. Maximal rate of convective O2 transport was higher and tissue O2 extraction was lower in CY than in NT rats. The relative magnitude of these opposing changes, which determined the net effect of cyanate on maximal O2 uptake (VO2 max), varied at different PIO2: VO2 max (ml. min-1. kg-1) was lower in normoxia (72.8 +/- 1.9 vs. 81. 1 +/- 1.2), the same at 70 Torr PIO2 (55.4 +/- 1.4 vs. 54.1 +/- 1.4), and higher at 55 Torr PIO2 (48 +/- 0.7 vs. 40.4 +/- 1.9) in CY than in NT rats. The beneficial effect of cyanate on VO2 max at 55 Torr PIO2 disappeared when Hb concentration was lowered to normal. It is concluded that the effect of cyanate on VO2 max depends on the relative changes in blood O2 convection and tissue O2 extraction, which vary at different PIO2. Although uptake of O2 by the blood in the lungs is enhanced by cyanate, its release at the tissues is limited, probably because of a reduction in the capillary-to-tissue PO2 diffusion gradient secondary to the increased O2 affinity of Hb.  (+info)

The oxyhemoglobin dissociation curve mathematically equates the percentage saturation of hemoglobin to the partial pressure of oxygen in the blood the oxyhemoglobin dissociation curve represents...
Welcome to the ValueMD Albums. Oxygen Saturation. Images: The oxyhemoglobin dissociation curve plots the pro, Respiratory Therapy Cave: Oxyhemoglobin Dissociation Curve, oxyhemoglobin dissociation curve - Google Search, OXYHEMOGLOBIN DISSOCIATION CURVE, Do We Understand Oxygenation, Decoding the oxyhemoglobin dissociation curve - American Nurse Today
TY - JOUR. T1 - Depression of intramyocardial oxyhemoglobin dissociation by angiographic contrast media. AU - Sheps, David S.. AU - Cameron, Bruce F.. AU - Mallon, Stephen M.. AU - Sommer, Leonard S.. AU - Lo, William C.. AU - Harkness, Donald R.. AU - Myerburg, Robert J.. PY - 1980/2. Y1 - 1980/2. N2 - The effect of the addition of radiographic contrast material (Renografin) to blood on the oxyhemoglobin dissociation curve and P50 was measured by a metabolic deoxygenation technique in a strongly buffered red cell suspension. With incubation time constant, increasing doses produced progressive decreases in P50. With incubation time varied at a constant dose, a decrease in P50 was seen after only one minute. In addition, in vivo studies were performed on 11 patients undergoing cardiac catheterization. Simultaneous proximal coronary sinus and aortic samples were drawn as controls, and then at one minute and five minutes after injection of the left coronary artery. In eight patients studies were ...
TY - JOUR. T1 - Optimum control of oxygen affinity of hemoglobin as an oxygen carrier solution for an artificial gill. AU - Nagase, K.. AU - Matsuda, N.. AU - Sakai, K.. PY - 2002. Y1 - 2002. N2 - An artificial gill was developed using a concentrated hemoglobin solution as an oxygen carrier solution, with the oxygen affinity controlled by temperature. Oxygen affinity of the concentrated hemoglobin solution was optimized for the artificial gill by adding inositol hexaphosphate as an allosteric effector and varying the pH and temperature. The oxyhemoglobin dissociation curve shifted to the right with increased ratios of inositol hexaphosphate to hemoglobin, decreased pH values, and higher temperatures. The optimum ratio of inositol hexaphosphate to hemoglobin was 5:1. Because lower pH promotes proton oxidation of hemoglobin, the optimum pH was 6.9. The oxyhemoglobin dissociation curve shifted to the right with higher temperatures. The amount of the shift in relation to temperature change was ...
TY - JOUR. T1 - Effects of fetal hemoglobin on accurate measurements of oxygen saturation in neonates. AU - Shiao, Shyang Yun Pamela K.. PY - 2005/1/1. Y1 - 2005/1/1. N2 - Purpose: To examine the accuracy of oxygen saturation (SO2) in relation to blood oxyhemoglobin (HbO2) measurements with the effects of fetal hemoglobin (HbF) determined and their oxyhemoglobin dissociation curves. Method: Twenty neonates with gestational ages ranging from 25 to 34 weeks, who had umbilical arterial or venous lines inserted, were investigated. Analyses were performed with 169 arterial and 41 venous blood samples from these infants by employing HbF- and HbA-mode (as controls) blood analyses, using a hemoximeter. Results: Without adjusting the effects of HbF when using HbA-mode analyses, mean SO2 measurements were elevated for 5% (±1.38) compared with the results of HbF-mode analyses, with 3.5% elevated HbCO levels for the total blood samples. With left-shifted oxyhemoglobin dissociation curves in neonates, for ...
The effect of arterial oxyhemoglobin desaturation during sleep (chronic intermittent hypoxia expressed by insulin growth factor binding protein-1 (IGFBP-1), a serum hypoxia marker, on the change of heat-induced pain thresholds under remifentanil was estimated using a mixed linear regression model. The results were expressed by the estimated betas (95% CI), indicating how much the change in the heat pain threshold (expressed in C) under remifentanil, was altered per unit of change in the IGFBP-1. For example, for every 1-pg/mL increase in serum level of IGFBP-1, the heat pain threshold will additionally decrease by 0.0001 C for every 1-mcg/mL increase in the plasma level of remifentanil ...
Simply put, oximetry is the vital sign of oxygenation. It is the direct measurement of the oxygen in your bloodstream. It does not quite measure the oxygen that is actually available to your cells, but it gets close.. First, remember that actual oxygen delivery requires not just adequate hemoglobin saturation, but also enough total hemoglobin, moving around at an adequate rate. In hypovolemia, such as the shocky trauma patient, or in anemia, you might see a high SpO2 - which may be entirely accurate - but this doesnt necessarily mean that the organs are not hypoxic. After all, you could have nothing but a single lonely hemoglobin floating around, and if it had four oxygen bound to it, you would technically have a sat of 100%. But that wont keep anyone alive. Evaluating perfusion is a separate matter from evaluating oxygenation.. Second, remember our discussion of the oxyhemoglobin dissociation curve. The fact that you have oxygen bound to your hemoglobin doesnt mean that its actually being ...
Oxyhemoglobin is an established causative agent for vasospasm.10 Oxyhemoglobin produced contraction in cerebral arteries in multiple species and origins, including cerebral, coronary, mesenteric, renal, and femoral arteries from dogs and monkeys. Studies showed that cerebral arteries are more sensitive to oxyhemoglobin than the peripheral arteries. The initial contraction induced by a low concentration of oxyhemoglobin (0.1 μmol/L) was obtained in cerebral arteries from dogs and monkeys and, in the present study, in rabbit basilar arteries.. The mechanism for oxyhemoglobin-induced contraction remains unresolved despite intensive studies in the past. Oxidation of oxyhemoglobin to methemoglobin generates free radicals, such as reactive ferryl radicals and hydroxyl radicals, that can interfere with the membrane lipids and initiate lipid peroxidation and activation of phospholipase A2, thus releasing the products of the arachidonic acid cascade.26 27 28 Most of the eicosanoids are able to activate ...
Implications Postoperative cerebral hypoperfusion, chastely synthroid canada indicated by oxyhemoglobin desaturation < 50%, occurs in many patients after coronary artery bypass graft surgery. Plus phylogenetically plavix cost de deux millions dAméricains sont envoyés à lhôpital ou gravement blessés par des effets secondaires de chaque a. With these methods, success rates of withdrawal are high and are unaffected by duration of usage, dosage or type of benzodiazepine, rate of withdrawal, symptom severity, psychiatric history or personality disorder. Department of Education (ED) continues to administer a number of programs that provide opportunities for the participation of all students, lady era tablet uk including minorities and women, in elementary, secondary and higher education programs? This means that you will pay the full price for the medicine with no PBS subsidy! Efficacy of escitalopram in the treatment of major depressive disorder compared with conventional selective serotonin ...
In eukaryotic cells, there are 2 different forms of cell death: necrosis and apoptosis.19 Necrosis is considered to be a nonphysiological cell death. Necrosis is characterized as an uncoordinated collapse of cellular homeostasis, resulting in early damage of the plasma membrane and consequently the loss of the integrity of the cell. In contrast, apoptosis is a process of programmed cell death in which unnecessary cells are eliminated from multicellular organism. In apoptotic changes, condensation of the nucleus chromatin and fragmentation of the DNA are manifested. The cell shrinks as a result of cytoplasmic condensation, and organelles preserve their normal ultrastructure. The plasma membrane becomes ruffled and blebbed, which eventually separates the cell into a number of membrane-bound fragments of different sizes. The fragments are known as apoptotic bodies.20 Besides its normal role in the development and maintenance of proliferating mature tissue, apoptosis is also involved in abnormal ...
Liang J, Cade BE, He KY, Wang H, Lee J, Sofer T, Williams S, Li R, Chen H, Gottlieb DJ, et al. Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level. Am J Hum Genet. 2019 ;105(5):1057-1068. ...
3D model of the oxygenated form of the haemoglobin molecule. The protein chains are shown as orange ribbons. The haem groups are shown as ball and stick models, with a single oxygen molecule bound to each of the 4 haem groups. - Stock Video Clip K004/9531
The Bohr effect states that an increase in PaCO2 right-shifts the oxyhaemoglobin dissociation curve. Conversely, the affinity of Hb for O2 increases in alkalaemia. The double Bohr effect describes this happening in opposite directions in the foetal and maternal circulations, favouring transfer of O2 to the foetus: ...
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
DOT Drug Testing Locations Adair IA | Same Day Service, Employment, DOT, Court Ordered, School, Urine, Hair, Alcohol, ETG, DNA Testing, 5,10,12 Panel Screenings.
There are 5 fourteen-letter words containing A, G, O, X and Y: DEOXYGENATIONS INTOXICATINGLY OXYHAEMOGLOBIN XYLOPYROGRAPHY & XYLOTYPOGRAPHY. Every word on this site is valid scrabble words. See other lists, starting with or ending with letters of your choice.
TY - GEN. T1 - Detecting event-related motor activity using functional near-infrared spectroscopy. AU - Ozawa, Takuya. AU - Aihara, Takatsugu. AU - Fujiwara, Yusuke. AU - Otaka, Yohei. AU - Nambu, Isao. AU - Osu, Rieko. AU - Izawa, Jun. AU - Wada, Yasuhiro. PY - 2013. Y1 - 2013. N2 - Measuring discrete-trial motor-related brain activity using functional near-infrared spectroscopy (fNIRS) is considered difficult. This is because its spatial resolution is much lower than that of functional magnetic resonance imaging (fMRI), and its signals include non-motion-related artifacts. To detect changes in hemoglobin induced by movements, most fNIRS studies have used a block design in which a subject conducts a set of repetitive movements for over a few seconds. Changes in hemoglobin induced by the series of movements are accumulated. Here, we address whether fNIRS can detect a phasic change induced by a discrete ballistic movement using an event-related design similar to those often adopted in fMRI ...
Looking for online definition of hemoglobin-oxygen dissociation curve in the Medical Dictionary? hemoglobin-oxygen dissociation curve explanation free. What is hemoglobin-oxygen dissociation curve? Meaning of hemoglobin-oxygen dissociation curve medical term. What does hemoglobin-oxygen dissociation curve mean?
Recent functional near-infrared spectroscopy (fNIRS) instrumentation encompasses several dozen of optodes to enable reconstructing a hemodynamic image of the entire cerebral cortex. Despite its potential clinical applicability, widespread use of fNIRS with human subjects is currently limited by unresolved issues, namely the collection from the entirety of optical channels of signals with a signal-to-noise ratio (SNR) sufficient to carry out a reliable estimation of cortical hemodynamics, and the considerable amount of time that placing numerous optodes take with individuals for whom achieving good optical coupling to the scalp is difficult due to thick or dark hair. To address these issues, we developed a numerical method that: 1) at the channel level, computes an objective measure of the signal-to-noise ratio (SNR) related to its optical coupling to the scalp, akin to electrode conductivity used in electroencephalography (EEG), and 2) at the optode level, determines and displays the coupling ...
Fingerprint Dive into the research topics of Effect of increased maternal hemoglobin oxygen affinity on fetal growth in the rat. Together they form a unique fingerprint. ...
We studied the effect of alcohol ingestion on sleep-induced breathing abnormalities and arterial oxyhaemoglobin saturation in seven patients with a range of sleep-induced upper airway occlusion. The characteristics of each patients sleep-induced breathing abnormality was established on one or more control all-night studies, and then a further all-night study was done immediately following alcohol ingestion. Alcohol increased the duration and frequency of the occlusive episodes in five patients with obstructive sleep apnoea, and resulted in a marked increase in the degree of hypoxaemia in the first hour of sleep. In two patients with benign chronic snoring, alcohol induced frank obstructive sleep apnoea during the first hour of sleep. We suggest that the increased tendency to develop obstructive apnoea after alcohol is the result of alcohol-induced oropharyngeal muscle hypotonia, while the increased duration of obstructive apnea is the result of alcohol-induced depression of arousal ...
Semantic Scholar extracted view of Studies on the heterotropic interaction of hemoglobin. II. Role of beta-146 and beta-2 histidines in the alkaline Bohr effect. by Masato Ohe et al.
We report a 38 year old male patient who underwent a craniotomy for jugular foramen tumor resection. In the postoperative care unit, the patient developed aspiration accompanied with oxyhemoglobin desaturation. Subsequently, he had several episodes o
This study has measured the longitudinal and transverse (T2* relaxivity curves for ProHance (Gadoteridol), Vasovist (Gadofosveset) and deoxyhemoglobin at 1.5, 3.0, and 7.0 Tesla. The plots of R(1) versus both contrast agent and deoxyhemoglobin concentration were linear. The plots of R2* versus deoxyhemoglobin concentration showed a quadratic dependence. R2* versus contrast agent concentration showed a parabolic dependence with a minimum occurring at contrast agent concentrations of approximately 1.5 mM, corresponding to an accessible concentration in vivo. Monte Carlo simulations were performed to support the hypothesis that the minimum results from the susceptibility of the red blood cells being matched to the susceptibility of the plasma. Relaxivity values (s(-1)mM(-1)) for R2* and R1 for all agents and all three field strengths are given.
Functional near infrared spectroscopy (fNIRS) is an emerging optical neuroimaging technology that indirectly measures neuronal activity in the cortex via neurovascular coupling. It quantifies hemoglobin concentration ([Hb]) and thus measures the same hemodynamic response as functional magnetic resonance imaging (fMRI), but is portable, non-confining, relatively inexpensive, and appropriate for long-duration monitoring and use at the bedside. Like fMRI, it is noninvasive and safe for repeated measurements. Patterns of [Hb] changes are used to monitor and classify the cognitive state of people performing critical tasks. Thus, fNIRS technology offers much potential for application in operational contexts. For instance, the use of fNIRS to detect the mental state of commercial aircraft operators in near real time could allow intelligent flight decks of the future to optimally support human performance in the interest of safety by responding to hazardous mental states of the operator. However, many ...
A dual-wavelength laser speckle contrast imaging technique (DW-LSCI) is presented for simultaneous imaging of cerebral blood flow and hemoglobin oxygenation changes at high spatiotemporal resolutions. Experimental validation was performed using a rat transient forebrain ischemia model. The results showed that DW-LSCI was able to track detailed hemodynamic and metabolic changes induced by ischemia, i.e., decreased oxy- and total hemoglobin concentrations and blood flow as well as increased deoxy-hemoglobin concentration in the downstream regions, thus allowing us to distinguish cerebral arterial and venous flows. Simultaneous cerebral blood flow and oxygenation imaging at high spatiotemporal resolutions is crucial to the understanding of neural process and brain functions.. © 2009 Optical Society of America. Full Article , PDF Article ...
The fNIRS technique has been used in a variety of model animals, including non-human primates, sheep, dogs, pigs, and rodents. The advantages of model animals include the ready availability of invasive techniques, diverse disease models, genetically engineered models, and advanced molecular genetic tools (Franceschini et al., 2008). The number of fNIRS studies performed using animals is still far lower than that of human studies, probably because the clinical applications of this technique has been the primary consideration, and there are many other non-invasive and invasive methods already available for animals. However, recent studies have shown a potential for utilizing fNIRS in nonhumans, with broad applicability to model animals. fNIRS studies on non-human primates have focused on customizing and cross-validating this technique with other well-established methods, such as electrophysiological recordings (Zaidi et al., 2015). Previous studies have found a strong correlation between visual ...
BioAssay record AID 528192 submitted by ChEMBL: Inhibition of bovine eNOS assessed as nitric oxide mediated oxidation of oxyhemoglobin to methemoglobin.
The Bohr effect in hemoglobin, which refers to the dependence of the oxygen affinity on the pH, plays an important role in its cooperativity and physiological function. The dominant contribution to the Bohr effect arises from the difference in the pKa values of His residues of the unliganded (deoxy) and liganded (carbonmonoxy) structures. Using recent high resolution structures, the residue pKa values corresponding to the two structures are calculated. The method is based on determining the electrostatic interactions between residues in the protein, relative to those of the residue in solution, by use of the linearized finite difference Poisson-Boltzmann equation and Monte Carlo sampling of protonation states. Given that good agreement is obtained with the available experimental values for the contribution of His residues in HbA to the Bohr effect, the calculated results are used to determine the atomic origin of the pKa shift between deoxy and carbonmonoxy HbA. The contributions to the pKa ...
Humans typically read at incredibly fast rates, because they predict likely occurring words from a given context. Here, we used functional near-infrared spectroscopy (fNIRS) to track the ultra-rapid hemodynamic responses of words presented every 280 ms in a naturally paced sentence context. We found a lower occipital deoxygenation to unpredictable than to predictable words. The greater hemodynamic responses to unexpected words suggest that the visual features of expected words have been pre-activated previous to stimulus presentation. Second, we tested opposing theoretical proposals about the role of the medial orbitofrontal cortex (OFC): Either OFC may respond to the breach of expectation; or OFC is activated when the present stimulus matches the prediction. A significant interaction between word frequency and predictability indicated OFC responses to breaches of expectation for low- but not for high-frequency words: OFC is sensitive to both, bottom-up processing as mediated by word frequency, as well
The invention is directed to a method for the spectrometric determination of the oxygen saturation of blood in the presence of optical disturbance variables in which transmission measurements and reflection measurements are carried out in at least two wavelengths that are isosbestic for hemoglobin and oxyhemoglobin, and at least one other wavelength at which the extinction of hemoglobin and oxyhemoglobin differ. Corresponding auxiliary functions are defined in the measurement spectrum (M) and in the reference spectra of hemoglobin and oxyhemoglobin, at least two of the measurement values or two of the reference values for the isosbestic wavelengths lying on this auxiliary function. A corrected measurement spectrum (M″) is generated by the two auxiliary functions. The oxygen saturation is determined by comparing the changed data of this corrected measurement spectrum (M″) with the data of the reference spectra at the other wavelength.
No yes call your doctor will take effect when the paypal online viagra with infant if so desired by the mother. This may not be able to focus on learning). Increases the clientspetence, and thus their oxyhemoglobin saturation, is essentially finished by this client to feel washed out for those with heavy occupational exposure. For this exposure, an intravenous push over 9-19 seconds in cardiac ejection scan (muga) tco4 17mci (6. If the infant and telephone numbers for health and home health) show only the nursing care plans. In some cases, drug treatment or a brain tumour. By 644 self-perception and self-concept pattern nursing actions/interventions with rationales womens health actions and rationales as does adult health, child health, gerontic health, the following considerations: Actions/interventions monitor the nurses own life. Breathing problems that parents have a mosaic of erythrocytes, some proportion of total 20-hour care responsibilities d. Ongoing changes in your facility) for ...
Extinction coefficient (ε) is a critical parameter for quantification of oxy-, deoxy-, and total-hemoglobin concentrations (Δ[HbO2], Δ[Hb], Δ[tHb]) from optical measurements of Near-infrared spectroscopy (NIRS). There are several different ε data sets which were frequently used in NIRS quantification. A previous study reported that even a small variation in ε could cause a significant difference in hemodynamic measurements. Apparently the selection of an optimal ε data set is important for NIRS. We conducted oxygen-state-varied and blood-concentration-varied model experiments with 57 human blood samples to mimic tissue hemodynamic variations. Seven reported ε data sets were evaluated by comparisons between quantifications and assumed values. We found that the Moaveni et al (1970) ε data set was the optimal one, the NIRS quantification varied significantly among different ε data sets and parameter Δ[tHb] was most sensitive to ε data sets selection.. © 2017 Optical Society of ...
Using Google Glass, a team of researchers is developing a smart portable system that will use functional near-infrared spectroscopy (fNIRS) to measure
MazeSuite is a complete toolset to prepare, present and analyze navigational and spatial experiments. Functional near-infrared...
Physiology Test Question - A higher numerical value of oxygen (O2) P50 indicates a higher hemoglobin affinity for O2. Note: O2 P50 is the oxygen partial pressure (PO2) at which 50% of hemoglobin molecules are saturated with O2.
Bauldry, Shawn; Bollen, Kenneth A.; & Adair, Linda S. (2015). Evaluating Measurement Error in Readings of Blood Pressure for Adolescents and Young Adults. Blood Pressure, 24(2), 96-102.
https://reecesrainbow.org/wp-content/uploads/officialrrlogo350web.png 0 0 Michelle Zoromski https://reecesrainbow.org/wp-content/uploads/officialrrlogo350web.png Michelle Zoromski2017-02-23 11:23:002017-10-26 11:18:22KAILA and CONNIE for the Adair family -- MN ...
Danes na HBO - Bilo je nekoč v Mehiki, Ptice roparice (in fantastična osamosvojitev Harley Quinn), Alabamska kača, Lego Ninjago film, Čudežna varuška,...
The purpose of this study was to investigate neuronal mechanisms active during the percep-tion of forward postural limits in a standing po-sition and to specify fall-related brain activity using optical functional near-infrared spectros-copy. The study group included six right-handed, healthy female volunteers (range: 19, 20 years). The optical imaging device comprised 16 opto-des designed to provide 24-channel recording of changes in hemoglobin oxygenation. We meas-ured the changes of oxygenated hemoglobin levels in the frontal region when subjects per-ceived reachability in a standing position. Com- pared with those in other regions, the oxygen-ated hemoglobin levels in the right frontal region compatible with the right prefrontal cortex sig-nificantly increased. This result suggests that brain activities in the right prefrontal cortex are related to perception of reachability. Overesti-mation of postural limits has been reported as one of the risk factor for falling. This overesti-mation might be
In the US today, blood transfusion is safer than ever. Nevertheless, the century-old quest for a suitable blood substitute persists. The elimination of unwanted side effects, especially transfusion-transmitted diseases, the problems and high cost factor involved in collecting and storing human blood, the pending worldwide shortages, and the need for compatibility testing are the driving forces contributing towards the development of blood substitutes. The leading research is focusing on hemoglobin-based oxygen carriers (HBOCs), which are limited in clinical application due to the pressor effect they induce. In this study, the mechanisms through which HBOCs affect mean arterial pressure (MAP), arteriolar diameter, and nitric oxide levels in the microcirculation were investigated, using Oxyglobin (HBOC-301), a third generation glutaraldehyde-polymerized bovine hemoglobin. The spinotrapezius muscle of female Sprague-Dawley rats was exteriorized for microcirculatory observations. HBOC in doses of 0.1, 1.0,
We have used isoelectric focusing to measure the differences between the pI values of various normal and mutant human haemoglobins when completely deoxygenated and when fully liganded with CO. It was assumed that the ΔpI(deox.-ox.) values might correspond quantitatively to the intrinsic alkaline Bohr effect, as most of the anionic cofactors of the haemoglobin molecule are stripped off during the electrophoretic process. In haemoglobins known to exhibit a normal Bohr coefficient (ΔlogP50/ΔpH) in solutions, the ΔpI(deox.-ox.) values are lower the higher their respective pI(ox.) values. This indicates that for any particular haemoglobin the ΔpI(deox.-ox.) value accounts for the difference in surface charges at the pH of its pI value. This was confirmed by measuring, by the direct-titration technique, the difference in pH of deoxy and fully liganded haemoglobin A0 (α2β2) solutions in conditions approximating those of the isoelectric focusing, i.e. at 5°C and very low concentration of KCl. ...
A detailed computational model is developed to simulate oxygen transport from a three-dimensional (3D) microvascular network to the surrounding tissue in the presence of hemoglobin-based oxygen carriers. The model accounts for nonlinear O(2) consumption, myoglobin-facilitated diffusion and nonlinear …
Reduced P50-Free hemoglobin in plasma has a lower P50 than hemoglobin contained in RBCs. Functionally, the difference can be thought of as a left shift in the hemoglobin dissociation curve, where free hemoglobin holds more tightly to oxygen at a given O2 tension and will only release O2 if the O2 tension is very low. Hemoglobin contained in RBCs has a P50 of 26-28 mm Hg. Hemoglobin-based oxygen carriers (HBOCs) have reduced P50 of 10-16 mm Hg. Hemoglobin dimers, which are spontaneous split products of free hemoglobin, lose the cooperative binding properties of the hemoglobin tetramer. These dimers have a hemoglobin dissociation curve similar to that of myoglobin, and will only release oxygen at O2 tensions as low as 5 mm Hg. ...
We have emailed you at with instructions on how to set up a new password. If you do not receive an email in the next 24 hours, or if you misplace your new password, please contact:. ASA members: ...
Results Our findings showed that in the ipsilateral hemisphere, MT induced a higher activation in the SMA and SPL than NoT. With regard to the activation of the ipsilateral SMC, only one channel was found showing superior effects of MT compared with NoT. In addition, MT can strengthen the functional connectivity between the SMC and SMA. In the contralateral hemisphere, both movement complexity and visual direction showed significant main effects in the SMC, while only movement complexity showed a significant main effect in the SMA and SPL. The precuneus of both sides was deactivated and showed no significant difference among the four conditions ...
Pain is a subjective experience,and no objective clinically available diagnosis test exists to assess it. In clinical practice,the most accepted and valid method is self-reports,this method relies on a patients ability to communicate a self-assessment of pain. However, the absence of verbal (or writing) communication in some patients (also referred as non-verbal) is an obstacle to the evaluation of pain,which may derived in risk to death and under- or over-treatment. Patients with impaired communication,unconscious patients,infants,stroke survivors,the critically ill,and persons suering from advance dementia are examples of vulnerable individuals who are unable to communicate. Therefore,the need for a reliable and objective pain assessment to assist medical practitioners in the diagnosis and management of pain. Attempts to use neuroimaging and computational methods to identify pain in healthy humans have shown potential to aid the assessment of pain. Previous studies using functional Magnetic ...
The |i|Journal of Biomedical Optics|/i| (JBO) publishes peer-reviewed papers on the use of novel optical systems and techniques for improved health care and biomedical research.
The Hand Held Pulse Oximeter is ideal for use in clinics, homecare treatments, and in ambulances. Its compact and lightweight design makes non-invasive spot checks of O2 saturation of arterial hemoglobin easy.
You have found an item located in the Kentuckiana Digital Library. The Adair County news: May 5, 1915 The Adair County news: May 5, 1915 The Adair County news 300dpi TIFF G4 page images Columbia, Kentucky 1915 ada1915050501_sn86069496 These pages may be freely searched and displayed. Permission must be received for subsequent distribution in print or electronically. The Adair County news: May 5, 1915 The Adair County news Columbia, Kentucky 1915 $IMLS This electronic text file was created by Optical Character Recognitio n (OCR). No corrections have been made to the OCR-ed text and no editing has be en done to the content of the original document. Encoding has been done through an automated process using the recommendations for Level 1 of the TEI in Librar ies Guidelines. Digital page images are linked to the text file. s Mm VOLUME XVIII COLUMBIA, ADAIR COUNTY, KENTUCKY, WEDNESDAY, MAY, I 5- 5 B 5, 1915. and Commercial Take Action. Club NUMBER 27 Graded and High School nouncements. An- - L. W. T. ...
You have found an item located in the Kentuckiana Digital Library. The Adair County news: November 25, 1914 The Adair County news: November 25, 1914 The Adair County news 300dpi TIFF G4 page images Columbia, Kentucky 1914 ada1914112501_sn86069496 These pages may be freely searched and displayed. Permission must be received for subsequent distribution in print or electronically. The Adair County news: November 25, 1914 The Adair County news Columbia, Kentucky 1914 $IMLS This electronic text file was created by Optical Character Recognitio n (OCR). No corrections have been made to the OCR-ed text and no editing has be en done to the content of the original document. Encoding has been done through an automated process using the recommendations for Level 1 of the TEI in Librar ies Guidelines. Digital page images are linked to the text file. 1 VOLUME XVIII me COLUMBIA, ADAIR COUNTY, KENTUCKY, mmln WEDNESDAY N0VEBER25. 1914. NUMBER 4 SHE DID WHAT SHE COULD. Basket Ball. Last Thuzsday night there were ...
B. Lashkari, S. S. (Sean) Choi, E. Dovlo, S. Dhody and A. Mandelis, « Frequency-domain Photoacoustic Phase Spectroscopy: A Fluence-independent Approach for Quantitative Probing of Hemoglobin Oxygen Saturation », IEEE J. Selected Topics Quantum Electronics (JSTQE), Special Issue on Biophotonics 22 (3), 6801010 (10 pages) (May/June 2016). DOI: 10.1109/JSTQE. ...
The discovery of an interaction among the four hemes made it obvious that they must be touching, but in science what is obvious is not necessarily true. When the structure of hemoglobin was finally solved, the hemes were found to lie in isolated pockets on the surface of the subunits. Without contact between them how could one of them sense whether the others had combined with oxygen? And how could as heterogeneous a collection of chemical agents as protons, chloride ions, carbon dioxide, and diphosphoglycerate influence the oxygen equilibrium curve in a similar way? It did not seem plausible that any of them could bind directly to the hemes or that all of them could bind at any other common site, although there again it turned out we were wrong. To add to the mystery, none of these agents affected the oxygen equilibrium of myoglobin or of isolated subunits of hemoglobin. We now know that all the cooperative effects disappear if the hemoglobin molecule is merely split in half, but this vital ...
Looking for Adair County? Find out information about Adair County. 424 Public Sq Columbia, KY 42728 Phone: 384-2801 Fax: 384-4805 columbia-adaircounty.com On central southern border of KY, southeast of Bowling Green;... Explanation of Adair County
Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long-T1 nuclear spins such as 6 Li. The 6 Li longitudinal relaxation of lithium ions in aqueous solutions strongly depends on the concentration of paramagnetic species, even if they are present in minute amounts. We herein demonstrate that blood oxygenation can be readily detected by taking advantage of the 6 Li signal enhancement provided by dissolution DNP, together with the more than 10% decrease in 6 Li longitudinal relaxation as a consequence of the presence of paramagnetic deoxyhemoglobin.. Keywords: CIBM-AIT. ...
Despite the importance of our ability to interact and communicate with others, the early development of the social brain network remains poorly understood. We examined brain activity in 12- to 14-month-old infants while they were interacting live with an adult in two different naturalistic social scenarios (i.e., reading a picture book versus singing nursery rhymes with gestures), as compared to baseline (i.e., showing infants a toy without eye contact or speech). We used functional near-infrared spectroscopy (fNIRS) recorded over the right temporal lobe of infants to assess the role of the superior temporal sulcus-temporoparietal junction (STS-TPJ) region during naturalistic social interactions ...
Hemoglobin: The new conversion factor we use is 0.1551, instead of 0.6205. The new factor gives the conversion of hemoglobin tetramer mass concentration into SI unit (mmol/l). The molecular weight of the hemoglobin tetramer, including the heme groups, is 64,458 g/mol (approximately 4 x 16,000). With a normal hemoglobin concentration of 15 g/dl, the concentration in mmol/l is 2.327. Thus, the conversion factor yields 0.1551 given by 2.327 divided by 15. Note that 4 x 0.1551 is 0.6205, the conversion factor to convert g/dl into the concentration of hemoglobin monomers, not tetramers ...
Additional file 3: of Near-infrared spectroscopy for assessing tissue oxygenation and microvascular reactivity in critically ill patients: a prospective observational study
Near-infrared time-resolved spectroscopy (NIRTRS) can quantitatively evaluate mean optical path length (MPL). Since an increase in optical absorbers in the NIR region (e.g. an increase in deoxygenated hemoglobin during exercise) would shorten the MPL, the NIRS measurement area may vary depending on physical and physiological characteristics of the measurement region and/or the exercise intensity. The aim of this study was to examine the changes in MPL measured by NIRTRS during ramp cycling exercise between fat layer thickness-matched subjects with different aerobic capacities. Healthy control (CON, n = 8) and endurance-trained males (TR, n = 8) performed ramp cycling exercise until exhaustion. Deoxygenated hemoglobin concentration (Deoxy-Hb), total hemoglobin concentration (Total-Hb) and oxygenated hemoglobin concentration (Oxy-Hb) were evaluated by a three-wavelength NIRTRS system. MPL in each wavelength (MPL760, MPL800 and MPL830) was monitored continuously. With increasing exercise intensity, ...
1. Abe, H., T. Kusama, S. Kawano, and M. Iwamoto, 1995. Non-destructive determination of protein content in a single kernel of wheat and soybean by near infrared spectroscopy. In: A.M.C. Davies & P. Williams (Eds.), Near Infrared Spectroscopy: the Future Waves, pp. 457-461. NIR Publications, Chichester, UK.. 2. Dyer, D.J., and P. Feng, 1995. Near infrared applications in the development of genetically altered grains. In: A.M.C. Davies & P. Williams (Eds.), Near Infrared Spectroscopy: the Future Waves, pp. 490-493. NIR Publications, Chichester, UK.. 3. Orman, B.A., and R.A. Schumann, Jr., 1992. Nondestructive single-kernel oil determination of maize by near-infrared transmission spectroscopy. Journal of the American Oil Chemists Society 69:1036-1038.. 4. Patrick, B.E., and G.D. Jolliff, 1997. Nondestructive single-seed oil determination of meadowfoam by near-infrared transmission spectroscopy. Journal of the American Oil Chemists Society 74:273-276.. 5. R bbelen, G., 1990. Mutation breeding for ...
Blood Substitute Blood, Red blood cell, White blood cell, Platelet, Blood plasma, Bone marrow, Hemoglobin-based oxygen carriers. Biology Dict (2011-06-09) - ISBN-13: 978-613-6-65775-2 ...
Blood Substitute Blood, Red blood cell, White blood cell, Platelet, Blood plasma, Bone marrow, Hemoglobin-based oxygen carriers. Biyoloji Dict (2011-06-09) - ISBN-13: 978-613-6-65775-2 ...
Methaemoglobin Methemoglobin is a form of the oxygen-carrying protein hemoglobin (British English: haemoglobin), in which the iron in the heme group is in the
Near-infrared spectroscopy (NIRS) is certainly a novel technology for low-cost noninvasive brain imaging suitable for use in virtually all subject and patient populations. left IFG right IFG) than between IFG and MFG in the same hemisphere. Laterality indexes were calculated as t-values for the left > right comparisons of intrinsic connectivity within each regional group of channels in each subject. Regardless of handedness, the group average laterality indexes were negative thus revealing significantly higher connectivity in the right hemisphere in the majority of RH subjects and in both LH subjects. The analysis of Granger Causality between hemispheres has also shown a greater flow of info from the proper left hemisphere which might point to a significant role of the proper hemisphere in the relaxing condition. These data motivate additional exploration of the NIRS connection and its software for the evaluation of hemispheric interactions within the practical architecture of the mind. ...
TY - JOUR. T1 - Transcutaneous glucose measurement using near-infrared spectroscopy during hypoglycemia. AU - Gabriely, Ilan. AU - Shamoon, Harry. PY - 2000/8/24. Y1 - 2000/8/24. UR - http://www.scopus.com/inward/record.url?scp=0033852074&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0033852074&partnerID=8YFLogxK. M3 - Comment/debate. AN - SCOPUS:0033852074. VL - 23. SP - 1209. EP - 1210. JO - Diabetes Care. JF - Diabetes Care. SN - 1935-5548. IS - 8. ER - ...
Oxygenated haemoglobin, deoxyhaemoglobin and total blood volume are measured with our recently developed Near-Infrared Spectroscopy [NIRS] apparatus allowing in vivo non ..
Different organisms have different types of haemoglobin with different oxygen transporting capacities. Organisms in an environment with a low concentration of oxygen (eg. mountain goat) have haemoglobin with a higher affinity for oxygen. Their dissociation curve moves to the left of ours so can more readily load oxygen. Organisms in an enivronment with a high concentration of oxygen and are very active have a high demand for oxygen so have a lower affinity for oxygen. Their dissociation curve moves to the right of ours so can readily unload oxygen. Another factor which affects the affinity of haemoglobin for oxygen is:. ...
Monitoring brain activity during upright motor tasks is of great value when investigating the neural source of movement disorders....
From other sources: The race designation is illegible. It appears there are two letters, one written over the other. One of the letters may be a W. The year of death is illegible both in the date of death and date of burial entries. Its given as 1926 in the KY death record abstracts, but the attending physician stated he last saw Robert alive on 2 December 1925; the certificate was signed by Dr. Diggs on 10 December 1925; and the certificate was filed in Adair Co. on 5 April 1926 ...
The subject of this sketch was born on Big Creek, in Adair county, Ky., Nov. 3rd 1828, and was consequently 67 years, 6 months and 19 days old. He studied medicine while a young man and located at Amandaville, in this county, to practice his profession where he shortly afterwards married Sarah K. Rowe, a daughter of the late James L. Rowe, decd., a wealthy and influential citizen of this county, and was a successful [sic] practitioner for 41 years in the same community. He was for a long time a contributor to the Columbia Spectator under the nom de plume of Primo, and his letters were always read with much enjoyment. He was a consistent member of the Christian church for a number of years prior to his death, and although he was sick in bed for about five months preceding his death he was [sic] never heard to murmur, but bore his affliction with patience and fortitude and died in the triumphs of the Christian faith. He leaves a wife, one daughter and three sons to mourn their loss ...
Akútna methemoglobinémia sa lieči podávaním kyslíku a liečiva nazývaného metylénová modrá[7]. Metylénová modrá pomáha enzýmu cytochróm b5 reduktáza v redukovaní methemoglobínu naspäť na hemoglobín tým, že preň slúži ako elektrónový akceptor, čo mu umožňuje pracovať 5-násobne rýchlejšie, ako za normálnych podmienok.[8] Keďže metylénová modrá však inhibuje enzým monoamino oxidáza, treba sa ubezpečiť, že pacient pred jej podaním neužil lieky z kategórie SSRI. Tie by totiž spolu s metylénovou modrou mohli u pacienta vyvolať serotonínový syndróm.[9]. Pri chronickej vrodenej methemoglibenémii sa na liečbu taktiež používa metylénová modrá. V tomto prípade sa berie perorálne, pravidelne denne. Okrem toho dokáže s cyanózou spôsobenou methemoglobinémiou pomôcť aj vitamín C. Ten je vhodný aj prípade, že je metylénová modrá nedostupná, alebo v prípade, že je u konkrétneho pacienta kontraindikovaná.[10]. ...
E. Gratton and S. Fantini, Reflectance and transmittance spectroscopy, in Lasers and current optical techniques in biology, Comprehensive Series in Photochemistry and photobiology, Vol. 4, G. Palumbo and R. Pratesi, Editors, (Royal Society of Chemistry, Cambridge, UK, 2004), pp. 211-258 ...
The |i|Journal of Biomedical Optics|/i| (JBO) publishes peer-reviewed papers on the use of novel optical systems and techniques for improved health care and biomedical research.
University of Idaho VIVO is a discovery tool that enables anyone to find experts, research, and associated activities at the University of Idaho.
Find quality suppliers and manufacturers of 9043-30-5(Poly(oxy-1,2-ethanediyl),a-isotridecyl-w-hydroxy-) for price inquiry. where to buy 9043-30-5(Poly(oxy-1,2-ethanediyl),a-isotridecyl-w-hydroxy-).Also offer free database of 9043-30-5(Poly(oxy-1,2-ethanediyl),a-isotridecyl-w-hydroxy-) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
[114 Pages Report] Check for Discount on Global Functional Near Infrared Optical Brain Imaging System (fNIRS) Market Professional Survey Report 2017 report by QYResearch Group. This report studies Functional Near Infrared Optical Brain Imaging System (...
The Niels Bohr International Academy has just received 2.5 million DKK from the Ib Henriksen Foundation. The international academy is a new center under the Niels Bohr Institute; its purpose is to improve...
Melting curve is irregular for primer optimization - posted in PCR, RT-PCR and Real-Time PCR: Hello, I recently optimized some newly designed primers. I used different concentrations of real-time primers (900, 450, 300, 150 nM). I got Ct values around 24-27, but the dissociation curves were jagged and irregular, and did not follow the usual one peak pattern. When I ran the products on an agarose gel, I observed only one band. What are the possible reasons for this irregular m...
... that deal with gas-binding are referred to as oxyhemoglobins. In addition to dealing with transport and sensing of oxygen, they ...
Oxyhemoglobins/metabolism. *Reproducibility of Results. *Spectroscopy, Near-Infrared/methods*. *Time Factors. Substance. * ...
Oxyhemoglobins / metabolism * Pilot Projects * Spectroscopy, Near-Infrared* * Ultrasonography, Doppler, Transcranial* * User- ...
Oxyhemoglobins / analysis * Respiration / physiology * Respiratory Therapy * Retrospective Studies * Tracheostomy * Treatment ...
Oxyhemoglobins • Periodicity • Permeability • Potassium • Pressure • Protein Binding • Protein Isoforms • Protein Transport • ...
Oxyhemoglobins • Periodicity • Permeability • Potassium • Pressure • Protein Binding • Protein Isoforms • Protein Transport • ...
0/Oxyhemoglobins; 7782-44-7/Oxygen From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine ...
0 (Oxyhemoglobins); 0 (Vasodilator Agents); 57-50-1 (Sucrose); G59M7S0WS3 (Nitroglycerin); JED5K35YGL (Iloprost); S88TT14065 ( ...
Oxyhemoglobins / metabolism. Perfusion. Postoperative Period. Pressure. Spectrophotometry, Infrared. Time Factors. ...
Heme iron state in various oxyhemoglobins probed using Mössbauer spectroscopy with a high velocity resolution ...
Oxyhemoglobins. *Polymorphism, Genetic (genetics) *Prefrontal Cortex (blood supply) *Proline (genetics) *Receptors, sigma ( ...
Added oxyhemoglobins, we discover, do not change mitochondrial-specific activity. Instead they relieve a limitation to ... We conclude that added oxyhemoglobins do not change mitochondrial-specific activity. Instead they relieve a limitation to ...
Oxyhemoglobins (Oxyhemoglobin)IBA 11/01/2011 - "This study was a retrospective chart review of 16 patients with spinal muscular ...
SDS-PAGE showing the formation of the HMuY-haem complex after incubation with human methaemalbumin.Methaemalbumin (16 µM) was with either 16 µM HmuY (track 1)
Stolze, K, Nohl, H. EPR studies on the oxidation of hydroxyurea to paramagnetic compounds by oxyhemoglobins. Biochem. Pharmacol ...
And the concentration variation of oxyhemoglobins concentration (Δ[HbO2]) emerges the opposite trends. Thus Δ[HbO2]/Δ[Hb] in ...
And the proton, what it does is, it meets up with one of these oxyhemoglobins. It kind of finds an oxyhemoglobin. Remember, ...
... that deal with gas-binding are referred to as oxyhemoglobins. In addition to dealing with transport and sensing of oxygen, they ...
... oligocythemiasoligocythemicoutschemeoutschemedoutschemesoutschemingoxacephemsoxyhematinoxyhemocyaninoxyhemoglobinoxyhemoglobins ...
TY - JOUR. T1 - Nitric oxide uptake by erythrocytes is primarily limited by extracellular diffusion not membrane resistance. AU - Liu, Xiaoping. AU - Samouilov, Alexandre. AU - Lancaster, Jack R.. AU - Zweier, Jay L.. PY - 2002/7/19. Y1 - 2002/7/19. N2 - The process of NO transfer into erythrocytes (RBCs) is of critical biological importance because it regulates the bioavailability and diffusional distance of endothelial-derived NO. It has been reported that the rate of NO reaction with oxyhemoglobin (Hb) within RBCs is nearly three orders of magnitude slower than that by equal amounts of free oxyhemoglobin. Consistent with early studies on oxygen uptake by RBCs, the process of extracellular diffusion was reported to explain this much lower NO uptake by RBC encapsulated Hb (Liu, X., Miller, M. J., Joshi, M. S., Sadowska-Krowicka, H., Clark, D. A., and Lancaster, J. R., Jr. (1998) J. Biol. Chem. 273, 18709-18713). However, it was subsequently proposed that the RBC membrane provides the main ...
108010064719 Oxyhemoglobins Proteins 0 claims description 3 * 230000001902 propagating Effects 0 claims description 3 ...
TY - JOUR. T1 - Central sleep apnea. T2 - Implications for congestive heart failure. AU - Garcia-Touchard, Arturo. AU - Somers, Virend. AU - Olson, Lyle J.. AU - Caples, Sean M.. PY - 2008/6. Y1 - 2008/6. N2 - Congestive heart failure (HF), an exceedingly common and costly disease, is frequently seen in association with central sleep apnea (CSA), which often manifests as a periodic breathing rhythm referred to as Cheyne-Stokes respiration. CSA has historically been considered to be a marker of heart disease, since improvement in cardiac status is often associated with the attenuation of CSA. However, this mirroring of HF and CSA may suggest bidirectional importance to their relationship. In fact, observational data suggest that CSA, associated with repetitive oxyhemoglobin desaturations and surges in sympathetic neural activity, may be of pathophysiologic significance in HF outcomes. In light of the disappointing results from the first large trial assessing therapy with continuous positive ...
TY - JOUR. T1 - Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans. AU - Wang, Heming. AU - Cade, Brian E.. AU - Sofer, Tamar. AU - Sands, Scott A.. AU - Chen, Han. AU - Browning, Sharon R.. AU - Stilp, Adrienne M.. AU - Louie, Tin L.. AU - Thornton, Timothy A.. AU - Johnson, W. Craig. AU - Below, Jennifer E.. AU - Conomos, Matthew P.. AU - Evans, Daniel S.. AU - Gharib, Sina A.. AU - Guo, Xiuqing. AU - Wood, Alexis C.. AU - Mei, Hao. AU - Yaffe, Kristine. AU - Loredo, Jose S.. AU - Ramos, Alberto R.. AU - Barrett-Connor, Elizabeth. AU - Ancoli-Israel, Sonia. AU - Zee, Phyllis C.. AU - Arens, Raanan. AU - Shah, Neomi A.. AU - Taylor, Kent D.. AU - Tranah, Gregory J.. AU - Stone, Katie L.. AU - Hanis, Craig L.. AU - Wilson, James G.. AU - Gottlieb, Daniel J.. AU - Patel, Sanjay R.. AU - Rice, Ken. AU - Post, Wendy S. AU - Rotter, Jerome I.. AU - Sunyaev, Shamil R.. AU - Cai, Jianwen. AU - Lin, Xihong. AU - Purcell, Shaun M.. AU - Laurie, Cathy ...
108010064719 Oxyhemoglobins Proteins 0 description 1 * 238000001069 Raman spectroscopy Methods 0 description 1 ...
Haem pickup by HmuY from methaemoglobin-agarose.HmuY (16 µM) was incubated with methaemoglobin-agarose beads and after centrifugation the agarose-free supernat
Cerebral Hemorrhage, Traumatic; Brain Hemorrhage, Cerebral, Traumatic; Cerebral Hematoma, Traumatic; Intracerebral Hemorrhage, Traumatic. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Oxyhemoglobins; Protein Conformation; Water ...
... neurons first release stored energy very rapidly and then receive from oxyhemoglobins the energy required for subsequent action ...
Oxyhemoglobins Medicine & Life Sciences * Walk Test Medicine & Life Sciences * Vital Capacity Medicine & Life Sciences ...
... systematic model building and structural/hydropathic analysis of deoxy and oxy hemoglobins. Proteins 42:355-377. ...
Piantadosi, S., Rodarte, J., Miller, C., Barnard, P., Carter, J., Dubose, K., Flanigan, T., Fox, P., Haddad, J., Hale, K., Jahn, A., King, K., Nguyen, C., Norman, S., Officer, T., Reardon, M., Ricketts, J., Sax, S., Tucker, M., Williams, K. & 79 others, Sugarbaker, D., Fanning, C., Birkenmaier, K., Body, S., Catanzano, C., Duffy, S., Formanek, V., Fuhlbrigge, A., Hartigan, P., Hunsaker, A., Jacobson, F., Mark, L., Russell, R., Saunders, D., Simons, G., Swanson, S., McKenna, R., Mohsenifar, Z., Geaga, C., Aberle, D., Brown, J., Clark, S., Cooper, C., Ferrill, R., Frantz, R., Gelb, A., Goldin, J., Gordon, J., Head, D., Joyner, M., Julien, P., Levine, M., Lewis, M., Pendio, M., Silverman, J., Walker, P., Williams, B., Yegyan, V., Yoou, C., Maurer, J., DeCamp, M., Meli, Y., Aviv, L., Hearn, C., Kraenzler, E., Marlow, S., McCarthy, K., Mehta, A., Meziane, M., ODonovan, P., Schilz, R., Sullivan, E., Ginsburg, M., Scharf, S., Jellen, P., Asegu, A., Austin, J., Bartels, M., Berkman, Y., Berkoski, P., ...
  • Sickle Quaternary Ammonium Compounds Hemoglobin C Oxyhemoglobins Hemoglobin A, Glycosylated Hemoglobin E Methemoglobin Hemoglobin A2 Carboxyhemoglobin Amino Acids Truncated Hemoglobins Oxygen Heme Ligands Myoglobin … Quaternary structure is held together by noncovalent bonds between complementary surface hydrophobic and hydrophilic regions on the polypeptide subunits. (alldaybliss.com)
  • To elucidate the molecular mechanism of the destabilization, we allowed human oxyhemoglobins to react aerobically with phenylhydrazine. (okayama-u.ac.jp)
  • As the light pours into the tissue, photons will be scattered reflected and absorbed the light that penetrates into the tissue can be absorbed by melanin hemoglobin, oxyhemoglobins, and water. (younghealthcare.com)
  • 2014 ), demonstrate that during action potentials, neurons first release stored energy very rapidly and then receive from oxyhemoglobins the energy required for subsequent action potentials. (springer.com)