Oxycodone. Medical search

A semisynthetic derivative of CODEINE.

An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.

Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.

Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS.

Dosage forms of a drug that act over a period of time by controlled-release processes or technology.

Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.

The application of medical knowledge to questions of law.

Pupillary constriction. This may result from congenital absence of the dilatator pupillary muscle, defective sympathetic innervation, or irritation of the CONJUNCTIVA or CORNEA.

Disorders related or resulting from abuse or mis-use of opioids.

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

Analogs or derivatives of morphine.

Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.

Alkaloids found in OPIUM from PAPAVER that induce analgesic and narcotic effects by action upon OPIOID RECEPTORS.

An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.

A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.

A plant genus of the family FUMARIACEAE (classified by some in PAPAVERACEAE) that contains isoquinoline alkaloids.

GC-MS confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine. (1/207)

A procedure for the simultaneous confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine specimens by gas chromatography-mass spectrometry (GC-MS) is described. After the addition of nalorphine and naltrexone as the two internal standards, the urine is hydrolyzed overnight with beta-glucuronidase from E. coli. The urine is adjusted to pH 9 and extracted with 8% trifluoroethanol in methylene dichloride. After evaporating the organic, the residue is sequentially derivatized with 2% methoxyamine in pyridine, then with propionic anhydride. The ketone groups on hydrocodone, hydromorphone, oxycodone, oxymorphone, and naltrexone are converted to their respective methoximes. Available hydroxyl groups on the O3 and O6 positions are converted to propionic esters. After a brief purification step, the extracts are analyzed by GC-MS using full scan electron impact ionization. Nalorphine is used as the internal standard for codeine, morphine, and 6-acetylmorphine; naltrexone is used as the internal standard for the 6-keto-opioids. The method is linear to 2000 ng/mL for the 6-keto-opioids and to 5000 ng/mL for the others. The limit of quantitation is 25 ng/mL in hydrolyzed urine. Day-to-day precision at 300 and 1500 ng/mL ranged between 6 and 10.9%. The coefficients of variation for 6-acetylmorphine were 12% at both 30 and 150 ng/mL. A list of 38 other basic drugs or metabolites detected by this method is tabulated. (+info)

Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat. (2/207)

Our previous studies indicate that oxycodone is a putative kappa-opioid agonist, whereas morphine is a well documented micro-opioid agonist. Because there is limited information regarding the development of tolerance to oxycodone, this study was designed to 1) document the development of tolerance to the antinociceptive effects of chronically infused i.v. oxycodone relative to that for i. v. morphine and 2) quantify the degree of antinociceptive cross-tolerance between morphine and oxycodone in adult male Dark Agouti (DA) rats. Antinociceptive testing was performed using the tail-flick latency test. Complete antinociceptive tolerance was achieved in 48 to 84 h after chronic infusion of equi-antinociceptive doses of i.v. oxycodone (2.5 mg/24 h and 5 mg/24 h) and i.v. morphine (10 mg/24 h and 20 mg/24 h, respectively). Dose-response curves for bolus doses of i.v. and i.c.v. morphine and oxycodone were produced in naive, morphine-tolerant, and oxycodone-tolerant rats. Consistent with our previous findings that oxycodone and morphine produce their intrinsic antinociceptive effects through distinctly different opioid receptor populations, there was no discernible cross-tolerance when i.c.v. oxycodone was given to morphine-tolerant rats. Similarly, only a low degree of cross-tolerance (approximately 24%) was observed after i.v. oxycodone administration to morphine-tolerant rats. By contrast, both i.v. and i.c.v. morphine showed a high degree of cross-tolerance (approximately 71% and approximately 54%, respectively) in rats rendered tolerant to oxycodone. Taken together, these findings suggest that, after parenteral but not supraspinal administration, oxycodone is metabolized to a mu-opioid agonist metabolite, thereby explaining asymmetric and incomplete cross-tolerance between oxycodone and morphine. (+info)

An unusual multiple drug intoxication case involving citalopram. (3/207)

A 47-year-old male with a history of drug abuse and suicide attempts was found dead at home. The death scene investigation showed evidence of cocaine abuse and multiple drug ingestion. Citralopram, a new selective serotonin reuptake inhibitor, cocaine, oxycodone, promethazine, propoxyphene, and norpropoxyphene were identified and quantitated in the postmortem samples by gas chromatography-mass spectrometry. The concentration of citalopram in the femoral blood was 0.88 mg/L. The heart blood concentration was 1.16 mg/L. Femoral blood concentrations of the other drugs were as follows: cocaine, 0.03 mg/L; oxycodone, 0.06 mg/L; promethazine, 0.02 mg/L; propoxyphene, 0.02 mg/L; and norpropoxyphene, 0.07 mg/L. Other tissue samples were also analyzed. The concentrations of cocaine, oxycodone, promethazine, and propoxyphene in the blood, liver, brain, and gastric contents did not suggest an intentional overdose. However, the possibility of multiple drug interactions including citalopram was evident. In this case, the citalopram concentrations were consistent with those reported in fatal cases involving multiple drug use. Citalopram was present in urine at a concentration of 0.9 mg/L. (+info)

Kinetics and inhibition of the formation of 6beta-naltrexol from naltrexone in human liver cytosol. (4/207)

AIMS: To determine the kinetics of the formation of 6beta-naltrexol from naltrexone in human liver cytosol, and to investigate the role of potential inhibitors. METHODS: The kinetics of the formation of 6 beta-naltrexol from naltrexone were examined in eight human liver cytosol preparations using h.p.l.c. to quantify 6 beta-naltrexol and, the extent of inhibition of 6 beta-naltrexol formation was determined using chemical inhibitors. The formation of 6 beta-naltrexol and the back reaction of 6 beta-naltrexol to naltrexone were also examined in a microsomal preparation. RESULTS: The Vmax, Km and CLint values for the formation of 6 beta-naltrexol from naltrexone were in the ranges of 16-45 nmol mg-1 protein h-1, 17-53 microM and 0.3-2.2 ml h-1 mg-1 protein, respectively. The steroid hormones testosterone (Ki = 0.3 +/- 0.1 microM) and dihydrotestosterone (Ki = 0.7 +/- 0.4 microM) were the most potent competitive inhibitors of 6 beta-naltrexol formation, with naloxone, menadione and corticosterone also producing > 50% inhibition at a concentration of 100 microM. The opioid agonists morphine, oxycodone, oxymorphone and hydromorphone, and a range of benzodiazepines showed < 20% inhibition at 100 microM. In the microsomal preparation, there was no formation of naltrexone from 6beta-naltrexol nor any formation of 6beta-naltrexol from naltrexone. CONCLUSIONS: The intersubject variability in the kinetic parameters of 6beta-naltrexol formation could play a role in the efficacy of and patient compliance with naltrexone treatment. This variability could be due in part to a genetic polymorphism of the dihydrodiol dehydrogenase DD4, one of the enzymes reported to be responsible for the formation of 6beta-naltrexol from naltrexone. DD4 also has hydroxysteroid dehydrogenase activity which could account for the potent inhibition by the steroid hormones testosterone and dihydrotestosterone. The clinical significance of the latter finding remains to be established. (+info)

Morphine and alternative opioids in cancer pain: the EAPC recommendations. (5/207)

An expert working group of the European Association for Palliative Care has revised and updated its guidelines on the use of morphine in the management of cancer pain. The revised recommendations presented here give guidance on the use of morphine and the alternative strong opioid analgesics which have been introduced in many parts of the world in recent years. Practical strategies for dealing with difficult situations are described presenting a consensus view where supporting evidence is lacking. The strength of the evidence on which each recommendation is based is indicated. (+info)

I.v. ketoprofen for analgesia after tonsillectomy: comparison of pre- and post-operative administration. (6/207)

We have evaluated the safety and efficacy of ketoprofen during tonsillectomy in 106 adults receiving standardized anaesthesia. Forty-one patients received ketoprofen 0.5 mg kg(-1) at induction ('pre' ketoprofen group) and 40 patients after surgery ('post' ketoprofen group), in both cases followed by a continuous ketoprofen infusion of 3 mg kg(-1) over 24 h; 25 patients received normal saline (placebo group). Oxycodone was used for rescue analgesia. Patients in the ketoprofen groups experienced less pain than those in the placebo group. There was no difference between the study groups in the proportion of patients who were given oxycodone during the first 4 h after surgery. However, during the next 20 h, significantly more patients in the placebo group (96%) received oxycodone compared with patients in the 'pre' ketoprofen group (66%) and the 'post' ketoprofen group (55%) (P=0.002). Patients in the placebo group received significantly more oxycodone doses than patients in the two ketoprofen groups (P=0.001). Two patients (5%) in the 'pre' ketoprofen group and one (3%) in the 'post' ketoprofen group had post-operative bleeding between 4 and 14 h. All three patients required electrocautery. (+info)

A rapid and sensitive high-performance liquid chromatography-electrospray ionization-triple quadrupole mass spectrometry method for the quantitation of oxycodone in human plasma. (7/207)

A sensitive method for the determination of oxycodone concentrations in plasma by high-performance liquid chromatography (HPLC)-electrospray ionization-triple quadrupole mass spectrometry is described. The method is rugged, reliable, selective, and rapid with a run time of 2 min. One milliliter of plasma is made basic and extracted with 2-mL duplicate portions of 2% isoamyl alcohol in n-butyl chloride. The combined extracts are then evaporated to dryness, reconstituted in 100 microL of the mobile phase (15% methanol-85% water containing 0.1% acetic acid), and injected onto the HPLC. The limit of quantitation is 1 ng/mL, and the estimated limit of detection is 33 pg/mL (signal-to-noise = 3). Standard curves are linear over the range of 1 to 100 ng/mL with all correlation coefficient values greater than 0.9989. The method is used to determine the concentration of oxycodone in human plasma following the intravenous infusion of doses ranging from 5 to 15 mg in which the analysis of over 3000 plasma samples is required. (+info)

The simultaneous determination of codeine, morphine, hydrocodone, hydromorphone, 6-acetylmorphine, and oxycodone in hair and oral fluid. (8/207)

Recently, the abuse of prescription opiates as alternatives to heroin has become a national concern. The determination of a six-drug opiate panel, codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, and oxycodone, in hair and oral fluid using solid-phase extraction and capillary gas chromatography-mass spectrometry (GC-MS) is described. Oral fluid was obtained from the donor by insertion of absorptive collectors into the mouth. Hair was collected from the patient and powdered using stainless steel ball bearings in a mini bead-beater apparatus. Opiates present in the samples were extracted from a buffered, aqueous matrix using a solid-phase cartridge. The extracts were concentrated and the methoxime/BSTFA derivatives prepared in order to eliminate interference from the keto-opiates. The extracts were separated by GC-MS in electron impact mode. By utilizing methoxyamine, we were able to produce the methoxime derivatives required for single derivative production and chromatographically separate all six opiates. The routine analysis of these opiates in hair and oral fluid using GC-MS is described for the first time. (+info)

The clearance of oxycodone is 0.8 L/min. Oxycodone and its metabolites are mainly excreted in urine. Therefore, oxycodone ... of a dose of oxycodone, while O-demethylation of oxycodone into oxymorphone by CYP2D6 and 6-ketoreduction of oxycodone into 6- ... Use of oxycodone in early pregnancy appears relatively safe. Opioid withdrawal may occur if rapidly stopped. Oxycodone acts by ... Oxycodone is available in a variety of formulations for by mouth or under the tongue: Immediate-release oxycodone (OxyFast, ...

https://en.wikipedia.org/wiki/Oxycodone

The University of Sydney (2019). "Oxycodone". Australian Medicines Handbook. Retrieved 2019-05-08. Smith HS (July 2009). " ... The main types of opioids include morphine, oxycodone hydrochloride, fentanyl, naloxone, tapentadol, methadone and ...

https://en.wikipedia.org/wiki/Clinical_Opiate_Withdrawal_Scale

... pills designed to look like pharmaceutical-grade oxycodone pills, but which evidently don't contain any real oxycodone. This ... Due to the cartel's past and current operations of pressing fentanyl into blue counterfeit "oxycodone (lookalike) pills" ... oxycodone. They have also began coloring the fentanyl powder in different colors so that dealers in the U.S. don't accidentally ... oxycodone pills which are typically blue) as well as multicolored fentanyl powder so that it isn't accidentally (or ...

https://en.wikipedia.org/wiki/Sinaloa_Cartel

Axelopran/oxycodone - combination of a centrally active μ-opioid receptor agonist and a peripherally selective μ-, κ-, and δ- ... "Drug profile , Oxycodone/naltrexone". AdisInsight. Elite Pharmaceuticals. 16 April 2021. Archived from the original on 14 ... Lexanopadol (GRT-6006, GRT13106G) - non-selective opioid receptor agonist Oxycodone/naltrexone - combination of a μ-opioid ... Axelopran/oxycodone". AdisInsight. Theravance Biopharma. 1 October 2021. Retrieved 29 October 2022. "Drug profile , ...

https://en.wikipedia.org/wiki/List_of_investigational_analgesics

... oxycodone (Percocet; Oxycontin), hydromorphone (Dilaudid), and oxymorphone (Opana). Sedatives such as GHB and methaqualone ( ...

https://en.wikipedia.org/wiki/Prohibition_of_drugs

The DEA also said that six of Walgreens' Florida pharmacies ordered in excess of a million oxycodone pills a year. In contrast ... Walgreens and Oxycodone - USATODAY.com. Usatoday30.usatoday.com. Retrieved on September 5, 2013. "Walgreens to pay $80 million ... Over the past three years, its market share has increased, and 52 Walgreens are among the top 100 oxycodone purchasers in the ... Since 2009, Walgreens' Jupiter facility has been the largest distributor of oxycodone in the state of Florida, the DEA said. ...

https://en.wikipedia.org/wiki/Walgreens

Synthesis of Oxycodone from Codeine. Aug 2004 static snapshot of Rhodium site archive hosted by Erowid, May 2005 Oxycodone / 14 ... as well as of oxycodone. The latter can also be synthesized from thebaine, however. Codeinone can be described as the ...

https://en.wikipedia.org/wiki/Codeinone

Includes amphetamines and other stimulants (such as methylphenidate), opioids (such as morphine and oxycodone) and other strong ... CD2: amphetamine, methadone, morphine, fentanyl, oxycodone, tapentadol, etc. Prescriptions must be handwritten and are only ... hydrocodone and oxycodone; synthetic opioids: pethidine, methadone, fentanyl, and levorphanol; various sedative-hypnotics: ...

https://en.wikipedia.org/wiki/Regulation_of_therapeutic_goods

Oxycodone (BNM) Data Sheet. 13 March 2014. URL: www.medsafe.govt.nz/profs/Datasheet/o/oxydoneBNMtab.pdf (accessed 22 July 2015 ... oxycodone, and methadone. OIH is not necessarily confined to the original affected site. This means that if the person was ...

https://en.wikipedia.org/wiki/Opioid-induced_hyperalgesia

Gaskell H, Derry S, Stannard C, Moore RA (July 2016). Cochrane Pain, Palliative and Supportive Care Group (ed.). "Oxycodone for ... tramadol and oxycodone) are also often used to treat neuropathic pain. As is revealed in many of the Cochrane systematic ... For oxycodone the authors found very low quality evidence showing its usefulness in treating diabetic neuropathy and ...

https://en.wikipedia.org/wiki/Peripheral_neuropathy

"OxyContin® (oxycodone HCl) Extended-Release Tablets , Official Site for Patients & Caregivers". Oxycontin.com. Retrieved ...

https://en.wikipedia.org/wiki/Joss_Sackler

"The Kealohas, Cocaine Parties and Oxycodone". July 20, 2021. Mililani Mauka on Honolulu Star-Bulletin "Under the Surface with ... to illegally sell oxycodone pills, or use the pills to purchase cocaine. The Tattoo (1999) ISBN 1569474508 The Queen of Tears ( ...

https://en.wikipedia.org/wiki/Chris_McKinney

"Oxycodone and Acetaminophen (Professional Patient Advice)". Drugs.com. 11 November 2019. Archived from the original on 20 May ... oxycodone or hydrocodone. Another very commonly used analgesic combination includes paracetamol in combination with ...

https://en.wikipedia.org/wiki/Paracetamol

In one study comparing the potency of hydrocodone to that of oxycodone, it was found that it took 50% more hydrocodone to ... Marco CA, Plewa MC, Buderer N, Black C, Roberts A (April 2005). "Comparison of oxycodone and hydrocodone for the treatment of ... Its abuse liability is similar to morphine and less than oxycodone. Patients consuming alcohol, other opioids, anticholinergic ... Spiller HA (March 2003). "Postmortem oxycodone and hydrocodone blood concentrations". J. Forensic Sci. 48 (2): 429-31. doi: ...

https://en.wikipedia.org/wiki/Hydrocodone

Gaskell H, Derry S, Stannard C, Moore RA (July 2016). "Oxycodone for neuropathic pain in adults". The Cochrane Database of ... oxycodone, and morphine have not been well-studied for postherpetic neuralgia treatment. Acetaminophen and nonsteroidal anti- ...

https://en.wikipedia.org/wiki/Postherpetic_neuralgia

Alternatives limited to hydromorphone and oxycodone. There may be a role for sedating antihistamines for limited indications. ...

https://en.wikipedia.org/wiki/WHO_Model_List_of_Essential_Medicines_for_Children

"OxyContin® (oxycodone HCl) Extended-Release Tablets , Official Site for Patients & Caregivers". www.oxycontin.com. Retrieved 25 ...

https://en.wikipedia.org/wiki/Mortimer_Sackler

Oxycodone is the main active ingredient in various oral pain relief medications. High doses of opiates such as oxycodone can ... Odia, Yazmin Morales; Madhavi Jinka; Wendy C. Ziai (May 2010). "Severe Leukoencephalopathy Following Acute Oxycodone ... oxycodone, cocaine, and methadone. The dose-response relationship for these substances remains unclear.[citation needed] ...

https://en.wikipedia.org/wiki/Toxic_leukoencephalopathy

"OxyContin® (oxycodone HCl) Extended-Release Tablets , Official Site for Patients & Caregivers". Oxycontin.com. Retrieved ...

https://en.wikipedia.org/wiki/Richard_Sackler

For example, tramadol, oxycodone or hydrocodone. Opioids function on the central nervous system to provide pain relief. The ...

https://en.wikipedia.org/wiki/Antiarthritics

Those are refined into drugs like oxycodone. Raw opium contains about 8-14% morphine by dry weight, or more in high-yield ... that are processed by the pharmaceutical industry into drugs such as hydrocodone and oxycodone. Each of these goals has special ...

https://en.wikipedia.org/wiki/Papaver_somniferum

suggesting hospital officials failed to check his credentials ... provided at least 248 prescriptions for oxycodone .. for cash ...

https://en.wikipedia.org/wiki/Lewis_County_General_Hospital

An autopsy found that the cause of Boogaard's death was an accidental overdose of alcohol and oxycodone. "The coroner said with ... "Percocet oxycodone and acetaminophen tablets USP" (PDF). Endo Pharmaceuticals. May 2011. Archived from the original (PDF) on ...

https://en.wikipedia.org/wiki/Derek_Boogaard

A 2016 Cochrane review concluded that there is no good evidence to support or refute the suggestion that oxycodone, alone or in ... Cochrane Pain, Palliative and Supportive Care Group) (September 2016). "Oxycodone for pain in fibromyalgia in adults". The ...

https://en.wikipedia.org/wiki/Fibromyalgia

"Sentencing for Oxycodone Based on Faulty Calculation," New York Law Journal, August 5, 2015. "Accusatory Instruments and ... ". "Sentencing for Oxycodone Based on Faulty Calculation". "Accusatory Instruments and Jurisdictional Sufficiency". "Ruling ...

https://en.wikipedia.org/wiki/Daniel_Arshack

Omeprazole (Losec, Prilosec) Oxycodone: grapefruit juice enhances the exposure to oral oxycodone. And a randomized, controlled ... Grapefruit juice and increased the mean area under the oxycodone concentration-time curve (AUC(0-∞)) by 1.7 fold, the peak ... On the fourth day 10 mg of oxycodone hydrochloride were administered orally. Analgesic and behavioral effects were reported for ... "Grapefruit juice enhances the exposure to oral oxycodone". Basic & Clinical Pharmacology & Toxicology. 107 (4): 782-788. doi: ...

https://en.wikipedia.org/wiki/Grapefruit–drug_interactions

"NJ Teacher's Assistant Sold Oxycodone at School: Prosecutors". NBC New York. Retrieved April 24, 2019. School Data for the Fort ...

https://en.wikipedia.org/wiki/Fort_Lee_School_District

Next, Martin Freund and Edmund Speyer developed oxycodone, also from thebaine, at the University of Frankfurt in 1916. In 1920 ... Other opioids are semi-synthetic and synthetic drugs such as hydrocodone, oxycodone and fentanyl; antagonist drugs such as ... Davis MP, Goforth HW (2016). "Oxycodone with an opioid receptor antagonist: A review". Journal of Opioid Management. 12 (1): 67 ... They are frequently used combined with opioids, such as paracetamol combined with oxycodone (Percocet) and ibuprofen combined ...

https://en.wikipedia.org/wiki/Opioid

Silvasti, M; Rosenberg, P; Seppälä, T; Svartling, N; Pitkänen, M (May 1998). "Comparison of analgesic efficacy of oxycodone and ... Morphine vs Hydromorphone vs Oxycodone vs The Patch". Palliative Care Tips: Info for Health Professionals. Palliative & End of ... Release Oxycodone in Postoperative Pain". Journal of Clinical Pharmacology. 36 (7): 595-603. doi:10.1002/j.1552-4604.1996. ... "Within-subject comparison of the psychopharmacological profiles of oral hydrocodone and oxycodone combination products in non- ...

https://en.wikipedia.org/wiki/Equianalgesic

... and 30-mg doses of CR oxycodone had durations of action of 10 to 12 hours compared with IR oxycodone and oxycodone plus APAP ( ... 1995 In December the FDA approved OxyContin-controlled-release oxycodone which was the "first formulation of oxycodone that ... Treatment with CR oxycodone was safe and effective in this study, and its characteristics will be beneficial in the treatment ... The report by eight authors said that, "[t]reatment with CR oxycodone was safe and effective in this study, and its ...

https://en.wikipedia.org/wiki/Timeline_of_the_opioid_epidemic

The activity of oxycodone hydrochloride tablets is primarily due to the parent drug oxycodone. Oxycodone hydrochloride tablets ... Conversion from Oxycodone Hydrochloride Tablets to Extended-Release Oxycodone The relative bioavailability of oxycodone ... Oxycodone hydrochloride tablets contain oxycodone, a Schedule II controlled substance. As an opioid, oxycodone hydrochloride ... While taking oxycodone hydrochloride tablets DO NOT: *Drive or operate heavy machinery, until you know how oxycodone ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cc23de03-2569-920f-e053-2995a90a3699

Hydrocodone and oxycodone are opioids, drugs that are mostly used to treat extreme pain. ... Hydrocodone and oxycodone belong to a class of narcotic medicines called opiates. These medicines are man-made versions of the ... Hydrocodone and oxycodone are most often found in prescription painkillers. The most common painkillers that include these two ... Hydrocodone and oxycodone overdose occurs when someone intentionally or accidentally takes too much medicine containing these ...

https://medlineplus.gov/ency/article/007285.htm

JavaScript is disabled for your browser. Some features of this site may not work without it ...

https://apps.who.int:80/iris/browse?locale-attribute=en&authority=Oxycodone&type=mesh

The FDA has approved a new formulation of controlled-release oxycodone HCl designed to discourage misuse and abuse of the ... Controlled-release oxycodone tablets contain a large quantity of the drug, allowing extension of the dosing interval. ... In 2007, Purdue pled guilty to a felony count of misbranding oxycodone extended-release tablets with the intent to defraud and ... In an FDA news release, Bob Rappaport, MD, said, "Although this new formulation of [oxycodone] may provide only an incremental ...

https://www.medscape.com/viewarticle/719875

oxycodone drug - Shop and compare norco and millions of other products &, ... ... Re: oxycodone drug, norco library. Charles. E-mail: [email protected] Location: Salem, OR. The main thing Im worried NORCO ... Oxycodone drug - Powered by Public Access Pharmacy 2008-2011. norco discounted price, norco rodeo. We are glad to see you in ... norco (oxycodone drug) - Shop and compare norco and millions of other products &, services.. ...

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Oxycodone is an addictive opioid that can be deadly if misused. Learn about the signs of addiction and dependence and how ... Oxycodone Addiction. Oxycodone is one of the most prescribed painkillers in the world, but the opioid is also involved in ... Oxycodone Dependence and Addiction. A person can develop a tolerance to oxycodone in as little as two weeks. As their tolerance ... Oxycodone Overdose Symptoms. A person with a Percocet addiction or dependence on other oxycodone products may develop a number ...

https://www.drugrehab.com/addiction/prescription-drugs/oxycodone/

December 1, ...

https://www.opposingviews.com/tag/75535

... was caught with oxycodone in school, police say ...

https://www.delmarvanow.com/story/news/local/maryland/2016/09/30/crisfield-teacher-crockett-oxycodone/91274238/

JavaScript is disabled for your browser. Some features of this site may not work without it ...

https://extranet.who.int/iris/restricted/browse?authority=Oxycodone&type=mesh

An Experience with Oxycodone. Another Day of Oxy by ExOacer ... 20 mg of Oxycodone. The effects of this previous high are just ... Oxycodone has a slight speedy effect on me. I usually feel much more motivation to do stuff, and whatever Im doing seems to ... My body is numbed a bit while on Oxycodone, so even though the water was hot, it was almost like I didnt feel the temperature ... Also, I have used Oxycodone daily, for the past 25 days at the time of this writing. Daily total amounts range from 5 to 40 mgs ...

https://erowid.org/experiences/exp.php?ID=73666

OXYCODONE HYDROCHLORIDE (UNII: C1ENJ2TE6C) (OXYCODONE - UNII:CD35PMG570) OXYCODONE HYDROCHLORIDE. 10 mg. ACETAMINOPHEN (UNII: ... Oxycodone and Acetaminophen Tablets contain oxycodone, a Schedule II controlled substance. As an opioid, Oxycodone and ... oxyCODONE 10 MG / acetaminophen 325 MG Oral Tablet. PSN. 2. 1049214. acetaminophen 325 MG / oxycodone hydrochloride 10 MG Oral ... While taking Oxycodone and Acetaminophen Tablets DO NOT: *Drive or operate heavy machinery, until you know how Oxycodone and ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6599fe69-0685-40dd-be50-f992c4c37873

A college dropout from Phoenix made millions from a fentanyl trafficking empire built with not much more than his computer and a few friends.

https://www.azcentral.com/story/news/local/phoenix/2019/09/15/fake-oxycodone-sold-online-delivered-mail-made-man-from-phoenix-millionaire-aaron-shamo/2329055001/

A United Parcel Service employee was charged today with stealing packages containing medications while working. Anthony Dante Blanks, 26, of the 500 block of Songbird Lane, is accused of stealing p…

https://www.fayobserver.com/story/news/crime/2015/07/28/ups-employee-charged-with-trafficking/22258368007/

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Increased prescriptions of drugs containing oxycodone, such as OxyContin and Percocet, have led to an increasing number of people with opioid use disorders. (drugrehab.com)
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However, to truly appreciate the evolution of your loved one's prescription opioid addiction , one question can be particularly illuminating: what is the difference between OxyContin and oxycodone? (altamirarecovery.com)
OxyContin is an extended-release version of oxycodone developed by Purdue Pharma ostensibly to create a safer opioid that offered patients long-lasting relief from pain while minimizing the risk of addiction. (altamirarecovery.com)
Oxycodone is a potent and addictive synthetic opioid found in prescription medications like Percocet and OxyContin. (clearbrookinc.com)
OxyContin is a popular recreational drug due to its high oxycodone content. (californiadetox.com)
Opioids, such as OxyContin and oxycodone, work wonders when prescribed for people in severe pain. (newdirectionsforwomen.org)

Oxycodone is an opioid, a class of highly addictive drugs that also includes heroin, morphine and fentanyl. (ucsd.edu)
According to the criminal complaint, Sanchez and Borges were involved in the sale of approximately 7,500 counterfeit oxycodone pills that were found to contain fentanyl, a synthetic opioid. (justice.gov)
TCSO says in both cases, counterfeit oxycodone pills, suspected to contain fentanyl, were found. (fox7austin.com)
The Drug Enforcement Administration is warning of counterfeit prescription pills containing deadly amounts of fentanyl and methamphetamine after a recent uptick in drug overdose deaths.The DEA says the deadly pills are being manufactured by Mexican drug traffickers and marketed as prescription medications like Oxycodone, Adderall and Xanax. (wvtm13.com)
Authorities say drug traffickers are selling fakes of these medicines including fake Oxycodone pills with fentanyl and fake Adderall pills containing meth.Fentanyl is a synthetic opioid that is 100 times stronger than morphine. (wvtm13.com)
In early February, police in Jamestown, North Dakota issued a warning after they found counterfeit oxycodone pills containing fentanyl, according to The Jamestown Sun . The pills were blue, with an "M" on one side and a "30" on the other. (safemedicines.org)
Kaylar Junior Tawan Beltranlap, a 21-year-old San Diego resident, was sentenced in federal court today to 156 months in prison for distributing counterfeit oxycodone pills laced with fentanyl that resulted. (justice.gov)
Opioid analgesics (eg, long-acting oxycodone or fentanyl) are associated with fewer concerns about tolerance and dependency than many other opiates. (medscape.com)
Opioids, like fentanyl and oxycodone, are often prescribed for severe pain and can be highly addictive. (medlineplus.gov)

These highlights do not include all the information needed to use OXYCODONE HYDROCHLORIDE TABLETS safely and effectively. (nih.gov)
See full prescribing information for OXYCODONE HYDROCHLORIDE TABLETS. (nih.gov)
Oxycodone hydrochloride tablets expose users to risks of addiction, abuse, and misuse, which can lead to overdose and death. (nih.gov)
Accidental ingestion of oxycodone hydrochloride tablets, especially by children, can result in a fatal overdose of oxycodone. (nih.gov)
Prolonged use of oxycodone hydrochloride tablets during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life- threatening if not recognized and treated. (nih.gov)
Oxycodone hydrochloride tablets are an opioid agonist indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. (nih.gov)
Discuss availability of naloxone with the patient and caregiver and assess each patient's need for access to naloxone, both when initiating and renewing treatment with oxycodone hydrochloride tablets. (nih.gov)
For control of chronic pain, administer oxycodone hydrochloride tablets on a regularly scheduled basis, at the lowest dosage level to achieve adequate analgesia. (nih.gov)
Individually titrate oxycodone hydrochloride tablets to a dose that provides adequate analgesia and minimizes adverse reactions. (nih.gov)
Do not abruptly discontinue oxycodone hydrochloride tablets in a physically dependent patient because rapid discontinuation of opioid analgesics has resulted in serious withdrawal symptoms, uncontrolled pain, and suicide. (nih.gov)
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Doctors keep telling me that oxycodone (percocet 10/325) and oxycodone hydrochloride are the same why do the roxys make me so sick and not workon pain? (healthtap.com)
The US Food and Drug Administration (FDA) has approved an abuse-deterrent extended-release formulation of oxycodone ( Targiniq ER , Purdue Pharma LP), a combination of oxycodone hydrochloride and naloxone hydrochloride, the agency announced today. (medscape.com)

AUSTIN, Texas - The Travis County Sheriff's Office says they have responded to two recent deaths that are possibly due to counterfeit oxycodone pills. (fox7austin.com)

Oxycodone is the generic name of a semisynthetic opioid pain medication estimated to be twice as potent as morphine. (altamirarecovery.com)
According to Dr. Robert Glatter, an emergency physician in New York City, "people addicted to painkillers - such as oxycodone and morphine - have increasingly turned to street drugs like heroin …" This is the miserable and potentially lethal vortex millions of Americans find themselves in once they develop an addiction after receiving an opioid prescription. (vaildaily.com)

Oxycodone, a semi synthetic narcotic analgesic, is structurally similar to codeine. (loinc.org)
The most frequently prescribed opioids among women in and specific opioid medication, age group, U.S. geographic both groups were hydrocodone, codeine, and oxycodone. (cdc.gov)

Oxycodone is often combined with non-narcotic pain relievers, such as acetaminophen or aspirin, and sold under a variety of names, including: Percocet, Percodan, Tylox and Roxicet. (drugrehab.com)
Assess each patient's risk prior to prescribing Oxycodone and Acetaminophen Tablets, and monitor all patients regularly for the development of these behaviors and conditions [see WARNINGS]. (nih.gov)
Serious, life-threatening, or fatal respiratory depression may occur with use of Oxycodone and Acetaminophen Tablets. (nih.gov)
Monitor for respiratory depression, especially during initiation of Oxycodone and Acetaminophen Tablets or following a dose increase [see WARNINGS]. (nih.gov)
Accidental ingestion of Oxycodone and Acetaminophen Tablets, especially by children, can result in a fatal overdose of Oxycodone and Acetaminophen Tablets [see WARNINGS]. (nih.gov)
Prolonged use of Oxycodone and Acetaminophen Tablets during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. (nih.gov)
Reserve concomitant prescribing of Oxycodone and Acetaminophen Tablets and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate. (nih.gov)
Although the opioid component is the same ( oxycodone), Percocet in cludes Acetaminophen ( tylenol ) which in fact sets the limits of the maximal dose allowed. (healthtap.com)

Oxymorphone is a metabolite of Oxycodone. (loinc.org)
Genetic variation in CYP2D6 and CYP2C19 had a significant impact on oxymorphone/oxycodone ratios, with a 6.9-fold difference between CYP2D6 ultrarapid metabolizers (UMs) and poor metabolizers. (cdc.gov)

April 7, 2010 - The US Food and Drug Administration (FDA) has approved a new formulation of controlled-release oxycodone HCl ( Oxyontin , Purdue Pharmaceuticals) designed to discourage misuse and abuse of the medication, which is indicated for the management of moderate to severe pain when a continuous, around-the-clock analgesic is required for an extended period of time. (medscape.com)
Controlled-release oxycodone tablets contain a large quantity of the drug, allowing extension of the dosing interval. (medscape.com)
Cite this: FDA Approves New Formulation of Controlled-Release Oxycodone - Medscape - Apr 07, 2010. (medscape.com)

Opioid-naive patient: Initially, oxycodone 10 mg and naloxone 5 mg 12 hourly. (mims.com)
Max: Oxycodone 80 mg and naloxone 40 mg daily. (mims.com)
In patients with restless leg syndrome for at least 6 months and occurring ≥4 days per week during daytime after failure of previous dopaminergic treatment: Initially, oxycodone 5 mg and naloxone 2.5 mg 12 hourly. (mims.com)
Max: Oxycodone 60 mg and naloxone 30 mg daily. (mims.com)
When it is crushed and snorted, or crushed, dissolved and injected, the naloxone blocks the euphoric effects of the oxycodone, "making it less liked by abusers than oxycodone alone," the FDA said. (medscape.com)
The safety database supporting approval includes treatment of more than 3000 people with the new oxycodone/naloxone formulation. (medscape.com)
Cite this: FDA Approves Abuse-Deterrent Oxycodone/Naloxone Combo - Medscape - Jul 23, 2014. (medscape.com)

In 2007, Purdue pled guilty to a felony count of misbranding oxycodone extended-release tablets with the intent to defraud and mislead, with respect to the formulation being less likely to cause abuse, addiction, tolerance, and withdrawal. (medscape.com)
Developed by the Preclinical Addiction Research Consortium, located in the Department of Psychiatry at UC San Diego School of Medicine and at Skaggs School of Pharmacy and Pharmaceutical Sciences, the new cocaine and oxycodone biobanks include samples from 20 different organs, plus urine, blood and feces. (ucsd.edu)
These biobanks using an animal model help serve that purpose, providing deeper insight - and potential therapeutic targets - regarding the paths and pathologies of cocaine and oxycodone addiction. (ucsd.edu)
Finding new ways to treat and reduce addiction requires well-validated, long-term models of how cocaine and oxycodone impact and impair biological systems and functions. (ucsd.edu)
As a drug rehab in Massachusetts , we understand that once an oxycodone addiction has developed, quitting it can result in uncomfortable and even painful withdrawal symptoms. (clearbrookinc.com)
The oxycodone withdrawal symptoms timeline and severity of symptoms are often dependent on the duration of the person's addiction, their health, how often they use oxycodone, and whether they've used other substances. (clearbrookinc.com)
Oxycodone withdrawal duration is dependent on the severity of the person's addiction and how long they've been using oxycodone. (clearbrookinc.com)
The transition from oxycodone use to oxycodone addiction can be swift and potentially dangerous. (californiadetox.com)
Although oxycodone offers a lifeline for many struggling with severe pain and chronic or terminal conditions, opioid addiction can develop quite quickly, even when used exactly as prescribed. (californiadetox.com)
This means that while it's impossible to discount the medical benefits of oxycodone, it also carries a risk for abuse and addiction. (californiadetox.com)
It's these painkilling and euphoric effects that results in abuse of oxycodone, in many cases leading to full-blown addiction. (californiadetox.com)
In some cases, oxycodone addiction can develop after just a few days of using the medication. (californiadetox.com)
The amount of oxycodone you are taking and the method of delivery can increase the risk of addiction. (californiadetox.com)
The frequency of oxycodone dosages will also influence your risk profile for addiction. (californiadetox.com)

Doctors, do you think I can buy drugs like roxicodone (oxycodone) and percocet online? (healthtap.com)

Greenbelt, Maryland - U.S. District Judge Paul W. Grimm sentenced Benjamin K. Bray, age 30, of Davidsonville, Maryland, to eight years in prison followed by three years of supervised release for conspiracy to distribute and possess with intent to distribute heroin and oxycodone and to being a felon in possession of an explosive device. (atf.gov)
During the conspiracy, Bray began to use and distribute heroin as a cheaper substitute for the oxycodone, selling heroin to pay for the heroin he used. (atf.gov)
Ingesting oxycodone in this way delivers a high comparable to that of heroin. (californiadetox.com)

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CRISTOBAL often prescribed oxycodone in combination with Xanax (alprazolam) and/or Adderall (amphetamine), controlled substances that are themselves frequently abused and resold illicitly. (nicb.org)

The concomitant use of Oxycodone Tablets with all cytochrome P450 3A4 inhibitors may result in an increase in oxycodone plasma concentrations, which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression. (nih.gov)
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Hydrocodone and oxycodone overdose occurs when someone intentionally or accidentally takes too much medicine containing these ingredients. (medlineplus.gov)
Individuals seeking to abuse oxycodone have been able to release high levels of the opioid medication from the previously approved formulation, potentially resulting in overdose. (medscape.com)
Oxycodone is one of the most prescribed painkillers in the world, but the opioid is also involved in thousands of overdose deaths every year. (drugrehab.com)
Drinking alcohol while taking strong pain killers like oxycodone can result in breathing problems and increase the risk of an overdose, according to the National Institute on Alcohol Abuse and Alcoholism. (thehockeynews.com)
Opioid-related overdose and chronic use following an initial prescription of hydrocodone versus oxycodone. (harvard.edu)
Overdose of Gabapentin and Oxycodone in a Patient with End-Stage Renal Disease: A Case for Appropriate Interruptive Drug-Disease Alerts. (ahrq.gov)

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Opioids like oxycodone have contributed to a major epidemic in the United States, in which millions of people have developed opioid abuse. (clearbrookinc.com)
Tolerance to opioids like oxycodone builds rapidly, meaning you will need more of the medication to achieve the same effects, or you will need to take more frequent doses of the medication. (californiadetox.com)
When humans ingest opioids like oxycodone, they ultimately end up excreting traces of the drugs into the toilet. (wdef.com)

Oxycodone is the primary active ingredient found in various pain medications. (californiadetox.com)
If you have a history of abusing alcohol, prescription medications, or illicit drugs, you will be at heightened risk of developing opioid use disorder when using oxycodone long-term. (californiadetox.com)

In a paper published online in the April 21, 2021 issue of the journal eNeuro , an international team of researchers led by scientists at University of California San Diego School of Medicine describe the creation of two unique collections of more than 20,000 biological samples collected from laboratory rats before, during and after chronic use of cocaine and oxycodone. (ucsd.edu)
Researchers used a heterogeneous rat model that reflects the genetic diversity of humans and have been characterized as vulnerable or resistant to cocaine and oxycodone behaviors. (ucsd.edu)
The request concerned possible health effects from working inside a vault used to store drug evidence, including marijuana, cocaine, methamphetamine, and oxycodone. (cdc.gov)
Only methamphetamine particles were detected in the area air samples, while all the drugs (cocaine, methamphetamine, oxycodone, and THC) were measured in some of the PBZ and surface samples. (cdc.gov)

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CRISTOBAL was also convicted of two counts of oxycodone distribution pertaining to specific prescriptions. (nicb.org)
She was found not guilty of other counts of oxycodone distribution pertaining to other prescriptions. (nicb.org)
Starting in February 2013, federal prosecutors say Simon and five co-conspirators wrote, filled and sold fraudulent prescriptions for more than 11,000 oxycodone pills and "other controlled substances. (arlnow.com)
Simon allegedly wrote and sold hundreds of prescriptions for oxycodone and other controlled substances, despite knowing that the individuals in whose names the prescriptions were written were abusing, misusing, distributing, and/or selling the drugs," according to a press release . (arlnow.com)
According to the indictment, Simon directed Escobar, a receptionist and medical assistant at Simon's practice, to confirm calls from pharmacists seeking to verify his oxycodone prescriptions," the press release said. (arlnow.com)
Bray and his co-conspirators presented forged prescriptions for oxycodone pills to different pharmacies approximately twice a week from the spring of 2011 through the summer of 2012. (atf.gov)
Cognizant of this, the medical community generally approached oxycodone and other opioid prescriptions with some degree of caution for decades. (altamirarecovery.com)

Doctors prescribe oxycodone to treat moderate to severe pain but people also abuse the drug for its relaxing and euphoric effects. (drugrehab.com)
Oxycodone is used for moderate to severe pain. (bsuh.nhs.uk)
No. Oxycodone if given for different sorts of severe pain and not just pain from cancer or when people near the end of their lives. (bsuh.nhs.uk)
If you still have severe pain, take a second dose of the quick acting oxycodone. (bsuh.nhs.uk)
Oxycodone is chiefly used for the management of moderate to severe pain after injury or surgery. (californiadetox.com)

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FDA is ridding the market of single-ingredient oxycodone capsules that are being distributed without an FDA-approved application. (drugtopics.com)
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Oxycodone is a highly potent and addictive opioid that commands high prices in the black market because of demand by drug abusers. (nicb.org)

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By this stage, you will need to use oxycodone to function normally, and the absence of oxycodone will trigger the onset of adverse withdrawal symptoms. (californiadetox.com)

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Comparison of a Small Dose of Oxycodone and Sufentanil for the Prevention of Sufentanil-Induced Cough during General Anesthesia Induction: A Prospective Randomized Controlled Trial. (bvsalud.org)
This study is aimed at evaluating the effectiveness of a small dose of oxycodone and sufentanil in suppressing sufentanil -induced cough (SIC) during general anesthesia induction. (bvsalud.org)

Subjects will complete each of the following 5-week long periods (unless they withdraw from the trial): 1) placebo pills and topical lidocaine patches, 2)extended-release oxycodone pills and placebo(vehicle) patches, and 3)placebo pills and placebo patches. (clinicaltrials.gov)

According to the US Substance Abuse and Mental Health Services Administration's National Survey on Drug Use and Health, approximately 500,000 people abused oxycodone for the first time in 2008. (medscape.com)
In an FDA news release, Bob Rappaport, MD, said, "Although this new formulation of [oxycodone] may provide only an incremental advantage over the current version of the drug, it is still a step in the right direction. (medscape.com)
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In November 2012, Jenkins refused to sell oxycodone to one of his drug customers, resulting in an argument. (atf.gov)
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I have seen huge bottles of Vicodin and Oxycodone while I was visiting her," the friend told STAR magazine , delving into detail as to how deep the reality star is into the Opiate-based medication. (radaronline.com)
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Patient taking other oral oxycodone: Initiate at same total daily dose, 12 hourly. (mims.com)

But while oxycodone is highly effective for alleviating pain, it is also highly addictive. (altamirarecovery.com)
Is Oxycodone Addictive? (californiadetox.com)
Like all opioids, oxycodone can be highly addictive. (californiadetox.com)

As a condition of approval, the manufacturer is required to conduct a postmarketing study to evaluate the potential benefits of the new formulation with respect to abuse and misuse of oxycodone. (medscape.com)

Organisms1

Diseases3

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Psychiatry and Psychology2

Phenomena and Processes1

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Health Care1

GC-MS confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine. (1/207)

Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat. (2/207)

An unusual multiple drug intoxication case involving citalopram. (3/207)

Kinetics and inhibition of the formation of 6beta-naltrexol from naltrexone in human liver cytosol. (4/207)

Morphine and alternative opioids in cancer pain: the EAPC recommendations. (5/207)

I.v. ketoprofen for analgesia after tonsillectomy: comparison of pre- and post-operative administration. (6/207)

A rapid and sensitive high-performance liquid chromatography-electrospray ionization-triple quadrupole mass spectrometry method for the quantitation of oxycodone in human plasma. (7/207)

The simultaneous determination of codeine, morphine, hydrocodone, hydromorphone, 6-acetylmorphine, and oxycodone in hair and oral fluid. (8/207)

Oxycodone

Oxymorphone

Analgesics, Opioid

Hydrocodone

Morphinans

Delayed-Action Preparations

Narcotics

Forensic Medicine

Miosis

Opioid-Related Disorders

Morphine

Morphine Derivatives

Substance Abuse Detection

Opiate Alkaloids

Pain

Codeine

Cytochrome P-450 CYP2D6

Corydalis

GC-MS confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine. (1/207)

Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat. (2/207)

An unusual multiple drug intoxication case involving citalopram. (3/207)

Kinetics and inhibition of the formation of 6beta-naltrexol from naltrexone in human liver cytosol. (4/207)

Morphine and alternative opioids in cancer pain: the EAPC recommendations. (5/207)

I.v. ketoprofen for analgesia after tonsillectomy: comparison of pre- and post-operative administration. (6/207)

A rapid and sensitive high-performance liquid chromatography-electrospray ionization-triple quadrupole mass spectrometry method for the quantitation of oxycodone in human plasma. (7/207)

The simultaneous determination of codeine, morphine, hydrocodone, hydromorphone, 6-acetylmorphine, and oxycodone in hair and oral fluid. (8/207)

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