A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.
An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
The dialdehyde of malonic acid.
Electron-accepting molecules in chemical reactions in which electrons are transferred from one molecule to another (OXIDATION-REDUCTION).
An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.
Low-molecular-weight end products, probably malondialdehyde, that are formed during the decomposition of lipid peroxidation products. These compounds react with thiobarbituric acid to form a fluorescent red adduct.
The appearance of carbonyl groups (such as aldehyde or ketone groups) in PROTEINS as the result of several oxidative modification reactions. It is a standard marker for OXIDATIVE STRESS. Carbonylated proteins tend to be more hydrophobic and resistant to proteolysis.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water. EC
Isoprostanes derived from the free radical oxidation of ARACHIDONIC ACID. Although similar in structure to enzymatically synthesized prostaglandin F2alpha (DINOPROST), they occur through non-enzymatic oxidation of cell membrane lipids.
A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.
A nucleoside consisting of the base guanine and the sugar deoxyribose.
The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.
Organic compounds containing a carbonyl group in the form -CHO.
A direct-acting oxidative stress-inducing agent used to examine the effects of oxidant stress on Ca(2+)-dependent signal transduction in vascular endothelial cells. It is also used as a catalyst in polymerization reactions and to introduce peroxy groups into organic molecules.
A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage.
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.
A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH oxidase result in GRANULOMATOUS DISEASE, CHRONIC.
A series of prostaglandin-like compounds that are produced by the attack of free-radical species on unsaturated fatty acids, especially ARACHIDONIC ACID, of cellular MEMBRANES. Once cleaved from the lipid membrane by the action of phospholipases they can circulate into various bodily fluids and eventually be excreted. Although these compounds resemble enzymatically synthesized prostaglandins their stereoisometric arrangement is usually different than the "naturally occurring" compounds.
Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.
Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
A ubiquitous stress-responsive enzyme that catalyzes the oxidative cleavage of HEME to yield IRON; CARBON MONOXIDE; and BILIVERDIN.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
A family of ubiquitously-expressed peroxidases that play a role in the reduction of a broad spectrum of PEROXIDES like HYDROGEN PEROXIDE; LIPID PEROXIDES and peroxinitrite. They are found in a wide range of organisms, such as BACTERIA; PLANTS; and MAMMALS. The enzyme requires the presence of a thiol-containing intermediate such as THIOREDOXIN as a reducing cofactor.
Heterocyclic compounds in which an oxygen is attached to a cyclic nitrogen.
Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A sulfhydryl reagent which oxidizes sulfhydryl groups to the disulfide form. It is a radiation-sensitizing agent of anoxic bacterial and mammalian cells.
Hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of PEROXIREDOXINS. Thioredoxin is oxidized from a dithiol to a disulfide when acting as a reducing cofactor. The disulfide form is then reduced by NADPH in a reaction catalyzed by THIOREDOXIN REDUCTASE.
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
The process by which chemical compounds provide protection to cells against harmful agents.
The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A group of compounds that contain a bivalent O-O group, i.e., the oxygen atoms are univalent. They can either be inorganic or organic in nature. Such compounds release atomic (nascent) oxygen readily. Thus they are strong oxidizing agents and fire hazards when in contact with combustible materials, especially under high-temperature conditions. The chief industrial uses of peroxides are as oxidizing agents, bleaching agents, and initiators of polymerization. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Compounds containing the -SH radical.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Established cell cultures that have the potential to propagate indefinitely.
Elements of limited time intervals, contributing to particular results or situations.
Nitrogenous products of NITRIC OXIDE synthases, ranging from NITRIC OXIDE to NITRATES. These reactive nitrogen intermediates also include the inorganic PEROXYNITROUS ACID and the organic S-NITROSOTHIOLS.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. It has four methyl groups on the 6-chromanol nucleus. The natural d form of alpha-tocopherol is more active than its synthetic dl-alpha-tocopherol racemic mixture.
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
An iron-molybdenum flavoprotein containing FLAVIN-ADENINE DINUCLEOTIDE that oxidizes hypoxanthine, some other purines and pterins, and aldehydes. Deficiency of the enzyme, an autosomal recessive trait, causes xanthinuria.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme to ferrous iron, carbon monoxide and biliverdin in the presence of molecular oxygen and reduced NADPH. The enzyme is induced by metals, particularly cobalt. EC
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Molecules which contain an atom or a group of atoms exhibiting an unpaired electron spin that can be detected by electron spin resonance spectroscopy and can be bonded to another molecule. (McGraw-Hill Dictionary of Chemical and Technical Terms, 4th ed)
The normal length of time of an organism's life.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A potent oxidant synthesized by the cell during its normal metabolism. Peroxynitrite is formed from the reaction of two free radicals, NITRIC OXIDE and the superoxide anion (SUPEROXIDES).
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
An enzyme that catalyzes the reversible hydration of cis-aconitate to yield citrate or isocitrate. It is one of the citric acid cycle enzymes. EC
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Porphyrins which are combined with a metal ion. The metal is bound equally to all four nitrogen atoms of the pyrrole rings. They possess characteristic absorption spectra which can be utilized for identification or quantitative estimation of porphyrins and porphyrin-bound compounds.
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.
A THIOREDOXIN-dependent hydroperoxidase that is localized in the mitochondrial matrix. The enzyme plays a crucial role in protecting mitochondrial components from elevated levels of HYDROGEN PEROXIDE.
A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
An enzyme which catalyzes the hydrolysis of an aryl-dialkyl phosphate to form dialkyl phosphate and an aryl alcohol. It can hydrolyze a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. It may also mediate an enzymatic protection of LOW DENSITY LIPOPROTEINS against oxidative modification and the consequent series of events leading to ATHEROMA formation. The enzyme was previously regarded to be identical with Arylesterase (EC
The single layer of pigment-containing epithelial cells in the RETINA, situated closely to the tips (outer segments) of the RETINAL PHOTORECEPTOR CELLS. These epithelial cells are macroglia that perform essential functions for the photoreceptor cells, such as in nutrient transport, phagocytosis of the shed photoreceptor membranes, and ensuring retinal attachment.
The decrease in the cell's ability to proliferate with the passing of time. Each cell is programmed for a certain number of cell divisions and at the end of that time proliferation halts. The cell enters a quiescent state after which it experiences CELL DEATH via the process of APOPTOSIS.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
A family of thioltransferases that contain two active site CYSTEINE residues, which either form a disulfide (oxidized form) or a dithiol (reduced form). They function as an electron carrier in the GLUTHIONE-dependent synthesis of deoxyribonucleotides by RIBONUCLEOTIDE REDUCTASES and may play a role in the deglutathionylation of protein thiols. The oxidized forms of glutaredoxins are directly reduced by the GLUTATHIONE.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
A cell line derived from cultured tumor cells.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.
Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE.
A FLAVOPROTEIN enzyme that catalyzes the oxidation of THIOREDOXINS to thioredoxin disulfide in the presence of NADP+. It was formerly listed as EC
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Proteins found in any species of bacterium.
Abnormally high BLOOD GLUCOSE level.
Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A peroxiredoxin that is a cytosolic bifunctional enzyme. It functions as a peroxiredoxin via a single redox-active cysteine and also contains a Ca2+-independent acidic phospholipase A2 activity.
Products derived from the nonenzymatic reaction of GLUCOSE and PROTEINS in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of DIABETES MELLITUS.
A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.
Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.
Reductases that catalyze the reaction of peptide-L-methionine -S-oxide + thioredoxin to produce peptide-L-methionine + thioredoxin disulfide + H(2)O.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
A large class of organic compounds having more than one PHENOL group.
A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.
The processes whereby the internal environment of an organism tends to remain balanced and stable.
A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
A constellation of responses that occur when an organism is exposed to excessive heat. Responses include synthesis of new proteins and regulation of others.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
The mitochondria of the myocardium.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.
A contact herbicide used also to produce desiccation and defoliation. (From Merck Index, 11th ed)
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Electrophoresis in which a second perpendicular electrophoretic transport is performed on the separate components resulting from the first electrophoresis. This technique is usually performed on polyacrylamide gels.
Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.
Organic compounds that contain 1,2-diphenylethylene as a functional group.
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
A class of dityrosine-containing protein-derived molecules formed by OXIDATIVE STRESS. Their accumulation in plasma is associated with certain pathological conditions.
An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed)
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.
A derivative of acetic acid, N(CH2COOH)3. It is a complexing (sequestering) agent that forms stable complexes with Zn2+. (From Miall's Dictionary of Chemistry, 5th ed.)
A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals.
An enzyme of the oxidoreductase class that catalyzes the conversion of beta-D-glucose and oxygen to D-glucono-1,5-lactone and peroxide. It is a flavoprotein, highly specific for beta-D-glucose. The enzyme is produced by Penicillium notatum and other fungi and has antibacterial activity in the presence of glucose and oxygen. It is used to estimate glucose concentration in blood or urine samples through the formation of colored dyes by the hydrogen peroxide produced in the reaction. (From Enzyme Nomenclature, 1992) EC
Biphasic dose responses of cells or organisms (including microorganisms) to an exogenous or intrinsic factor, in which the factor induces stimulatory or beneficial effects at low doses and inhibitory or adverse effects at high doses.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
The main trunk of the systemic arteries.
Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS.
A transparent, biconvex structure of the EYE, enclosed in a capsule and situated behind the IRIS and in front of the vitreous humor (VITREOUS BODY). It is slightly overlapped at its margin by the ciliary processes. Adaptation by the CILIARY BODY is crucial for OCULAR ACCOMMODATION.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
The metabolic process of all living cells (animal and plant) in which oxygen is used to provide a source of energy for the cell.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane. (1/22885)

-The clinical efficacy of anthracycline antineoplastic agents is limited by a high incidence of severe and usually irreversible cardiac toxicity, the cause of which remains controversial. In primary cultures of neonatal and adult rat ventricular myocytes, we found that daunorubicin, at concentrations /=10 micromol/L induced necrotic cell death within 24 hours, with no changes characteristic of apoptosis. To determine whether reactive oxygen species play a role in daunorubicin-mediated apoptosis, we monitored the generation of hydrogen peroxide with dichlorofluorescein (DCF). However, daunorubicin (1 micromol/L) did not increase DCF fluorescence, nor were the antioxidants N-acetylcysteine or the combination of alpha-tocopherol and ascorbic acid able to prevent apoptosis. In contrast, dexrazoxane (10 micromol/L), known clinically to limit anthracycline cardiac toxicity, prevented daunorubicin-induced myocyte apoptosis, but not necrosis induced by higher anthracycline concentrations (>/=10 micromol/L). The antiapoptotic action of dexrazoxane was mimicked by the superoxide-dismutase mimetic porphyrin manganese(II/III)tetrakis(1-methyl-4-peridyl)porphyrin (50 micromol/L). The recognition that anthracycline-induced cardiac myocyte apoptosis, perhaps mediated by superoxide anion generation, occurs at concentrations well below those that result in myocyte necrosis, may aid in the design of new therapeutic strategies to limit the toxicity of these drugs.  (+info)

Base excision repair of oxidative DNA damage activated by XPG protein. (2/22885)

Oxidized pyrimidines in DNA are removed by a distinct base excision repair pathway initiated by the DNA glycosylase--AP lyase hNth1 in human cells. We have reconstituted this single-residue replacement pathway with recombinant proteins, including the AP endonuclease HAP1/APE, DNA polymerase beta, and DNA ligase III-XRCC1 heterodimer. With these proteins, the nucleotide excision repair enzyme XPG serves as a cofactor for the efficient function of hNth1. XPG protein promotes binding of hNth1 to damaged DNA. The stimulation of hNth1 activity is retained in XPG catalytic site mutants inactive in nucleotide excision repair. The data support the model that development of Cockayne syndrome in XP-G patients is related to inefficient excision of endogenous oxidative DNA damage.  (+info)

Chaperone activity with a redox switch. (3/22885)

Hsp33, a member of a newly discovered heat shock protein family, was found to be a very potent molecular chaperone. Hsp33 is distinguished from all other known molecular chaperones by its mode of functional regulation. Its activity is redox regulated. Hsp33 is a cytoplasmically localized protein with highly reactive cysteines that respond quickly to changes in the redox environment. Oxidizing conditions like H2O2 cause disulfide bonds to form in Hsp33, a process that leads to the activation of its chaperone function. In vitro and in vivo experiments suggest that Hsp33 protects cells from oxidants, leading us to conclude that we have found a protein family that plays an important role in the bacterial defense system toward oxidative stress.  (+info)

The Golgi apparatus plays a significant role in the maintenance of Ca2+ homeostasis in the vps33Delta vacuolar biogenesis mutant of Saccharomyces cerevisiae. (4/22885)

The vacuole is the major site of intracellular Ca2+ storage in yeast and functions to maintain cytosolic Ca2+ levels within a narrow physiological range. In this study, we examined how cellular Ca2+ homeostasis is maintained in a vps33Delta vacuolar biogenesis mutant. We found that growth of the vps33Delta strain was sensitive to high or low extracellular Ca2+. This strain could not properly regulate cytosolic Ca2+ levels and was able to retain only a small fraction of its total cellular Ca2+ in a nonexchangeable intracellular pool. Surprisingly, the vps33Delta strain contained more total cellular Ca2+ than the wild type strain. Because most cellular Ca2+ is normally found within the vacuole, this suggested that other intracellular compartments compensated for the reduced capacity to store Ca2+ within the vacuole of this strain. To test this hypothesis, we examined the contribution of the Golgi-localized Ca2+ ATPase Pmr1p in the maintenance of cellular Ca2+ homeostasis. We found that a vps33Delta/pmr1Delta strain was hypersensitive to high extracellular Ca2+. In addition, certain combinations of mutations effecting both vacuolar and Golgi Ca2+ transport resulted in synthetic lethality. These results indicate that the Golgi apparatus plays a significant role in maintaining Ca2+ homeostasis when vacuolar biogenesis is compromised.  (+info)

Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. (5/22885)

The interferon-inducible, double-stranded RNA-dependent protein kinase PKR has been implicated in anti-viral, anti-tumor, and apoptotic responses. Others have attempted to examine the requirement of PKR in these roles by targeted disruption at the amino terminal-encoding region of the Pkr gene. By using a strategy that aims at disruption of the catalytic domain of PKR, we have generated mice that are genetically ablated for functional PKR. Similar to the other mouse model of Pkr disruption, we have observed no consequences of loss of PKR on tumor suppression. Anti-viral response to influenza and vaccinia also appeared to be normal in mice and in cells lacking PKR. Cytokine signaling in the type I interferon pathway is normal but may be compromised in the erythropoietin pathway in erythroid bone marrow precursors. Contrary to the amino-terminal targeted Pkr mouse, tumor necrosis factor alpha-induced apoptosis and the anti-viral apoptosis response to influenza is not impaired in catalytic domain-targeted Pkr-null cells. The observation of intact eukaryotic initiation factor-2alpha phosphorylation in these Pkr-null cells provides proof of rescue by another eukaryotic initiation factor-2alpha kinase(s).  (+info)

Increased lipophilicity and subsequent cell partitioning decrease passive transcellular diffusion of novel, highly lipophilic antioxidants. (6/22885)

Oxidative stress is considered a cause or propagator of acute and chronic disorders of the central nervous system. Novel 2, 4-diamino-pyrrolo[2,3-d]pyrimidines are potent inhibitors of iron-dependent lipid peroxidation, are cytoprotective in cell culture models of oxidative injury, and are neuroprotective in brain injury and ischemia models. The selection of lead candidates from this series required that they reach target cells deep within brain tissue in efficacious amounts after oral dosing. A homologous series of 26 highly lipophilic pyrrolopyrimidines was examined using cultured cell monolayers to understand the structure-permeability relationship and to use this information to predict brain penetration and residence time. Pyrrolopyrimidines were shown to be a more permeable structural class of membrane-interactive antioxidants where transepithelial permeability was inversely related to lipophilicity or to cell partitioning. Pyrrole substitutions influence cell partitioning where bulky hydrophobic groups increased partitioning and decreased permeability and smaller hydrophobic groups and more hydrophilic groups, especially those capable of weak hydrogen bonding, decreased partitioning, and increased permeability. Transmonolayer diffusion for these membrane-interactive antioxidants was limited mostly by desorption from the receiver-side membrane into the buffer. Thus, in this case, these in vitro cell monolayer models do not adequately mimic the in vivo situation by underestimating in vivo bioavailability of highly lipophilic compounds unless acceptors, such as serum proteins, are added to the receiving buffer.  (+info)

Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress. (7/22885)

Iron regulatory protein-1 (IRP-1) controls the expression of several mRNAs by binding to iron-responsive elements (IREs) in their untranslated regions. In iron-replete cells, a 4Fe-4S cluster converts IRP-1 to cytoplasmic aconitase. IRE binding activity is restored by cluster loss in response to iron starvation, NO, or extracellular H2O2. Here, we study the effects of intracellular quinone-induced oxidative stress on IRP-1. Treatment of murine B6 fibroblasts with menadione sodium bisulfite (MSB), a redox cycling drug, causes a modest activation of IRP-1 to bind to IREs within 15-30 min. However, IRE binding drops to basal levels within 60 min. Surprisingly, a remarkable loss of both IRE binding and aconitase activities of IRP-1 follows treatment with MSB for 1-2 h. These effects do not result from alterations in IRP-1 half-life, can be antagonized by the antioxidant N-acetylcysteine, and regulate IRE-containing mRNAs; the capacity of iron-starved MSB-treated cells to increase transferrin receptor mRNA levels is inhibited, and MSB increases the translation of a human growth hormone indicator mRNA bearing an IRE in its 5'-untranslated region. Nonetheless, MSB inhibits ferritin synthesis. Thus, menadione-induced oxidative stress leads to post-translational inactivation of both genetic and enzymatic functions of IRP-1 by a mechanism that lies beyond the "classical" Fe-S cluster switch and exerts multiple effects on cellular iron metabolism.  (+info)

Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae. (8/22885)

The so-called thioredoxin system, thioredoxin (Trx), thioredoxin reductase (Trr), and NADPH, acts as a disulfide reductase system and can protect cells against oxidative stress. In Saccharomyces cerevisiae, two thioredoxins (Trx1 and Trx2) and one thioredoxin reductase (Trr1) have been characterized, all of them located in the cytoplasm. We have identified and characterized a novel thioredoxin system in S. cerevisiae. The TRX3 gene codes for a 14-kDa protein containing the characteristic thioredoxin active site (WCGPC). The TRR2 gene codes for a protein of 37 kDa with the active-site motif (CAVC) present in prokaryotic thioredoxin reductases and binding sites for NADPH and FAD. We cloned and expressed both proteins in Escherichia coli, and the recombinant Trx3 and Trr2 proteins were active in the insulin reduction assay. Trx3 and Trr2 proteins have N-terminal domain extensions with characteristics of signals for import into mitochondria. By immunoblotting analysis of Saccharomyces subcellular fractions, we provide evidence that these proteins are located in mitochondria. We have also constructed S. cerevisiae strains null in Trx3 and Trr2 proteins and tested them for sensitivity to hydrogen peroxide. The Deltatrr2 mutant was more sensitive to H2O2, whereas the Deltatrx3 mutant was as sensitive as the wild type. These results suggest an important role of the mitochondrial thioredoxin reductase in protection against oxidative stress in S. cerevisiae.  (+info)

Oxidative stress leads to many kinds of diseases. Currently, urinary 8-hydroxydeoxyguanosine (8-OHdG) is widely measured as an oxidative stress biomarker. There is a specific advantage if saliva can be used as the sample to measure the oxidative stress biomarker, because saliva is much easier to collect than urine. In this study, we investigated the measurement of 8-hydroxyguanine (8-OHGua) as an oxidative stress marker in saliva, by a column switching HPLC system equipped with an electrochemical detector (HPLC-ECD). The 8-OHGua in saliva could be detected as a single peak by HPLC-ECD. The average level of 8-OHGua in saliva was 3.80 ng/mL in ordinary, non-smoking subjects. The salivary 8-OHGua levels of smokers were significantly higher than those of non-smokers. Salivary 8-OHGua may be a useful noninvasive and promising oxidative stress biomarker.
TY - JOUR. T1 - Protective effects of L-arginine on pulmonary oxidative stress and antioxidant defenses during exhaustive exercise in rats. AU - Lin, Wan Teng. AU - Yang, Suh-Ching. AU - Chen, Kung Tung. AU - Huang, Chi Chang. AU - Lee, Ning Yuean. PY - 2005/8. Y1 - 2005/8. N2 - Aim: To assess the effects of L-arginine (L-Arg) supplementation on pulmonary oxidative stress and antioxidant defenses in rats after exhaustive exercise. Methods: Rats were randomly divided into four groups: sedentary control (SC), sedentary control with L-Arg treatment (SC+Arg), exhaustive exercise with control diet (E) and exhaustive exercise with L-Arg treatment (E+Arg). Rats in groups SC+Arg and E+Arg received a 2% L-Arg diet. Rats in groups E and E+Arg underwent an exhaustive running test on a motorized treadmill. Pulmonary oxidative stress indices [xanthine oxidase (XO), myeloperoxidase (MPO), and malondialdehyde (MDA)] and antioxidant defense systems [superoxide dismutase (SOD), catalase (CAT), glutathione ...
We show that RES increase the expression of FoxO1A, FoxO3A, and FoxO4 under chronic oxidative stress conditions (Fig. 2). This response is consistent with a homeostatic response to protect lens epithelial cells. Baur et al. 28 found that RES extended lifespan in a high-fat diet mouse model and that it appeared to be dependent on activation of Sir2. It was further demonstrated that the Sir2 homolog SIRT1 controls the cellular response to stress by regulating the FoxO family. 29 SIRT1 and the FoxO transcription factor FoxO3 form a complex in cells in response to oxidative stress. In our study, we found that RES increased expression of FoxO3A and also enhanced the expression of FoxO1A and FoxO4 under chronic oxidative stress conditions, suggesting that FoxO1A and FoxO4 may also be involved in the protective effects of RES (Fig. 2). This is further supported by the finding that knockdown of individual FoxOs by FoxO siRNAs decreases the protective effects of RES against acute oxidative stress. A ...
TY - JOUR. T1 - The use of hyperoxia to induce chronic mild oxidative stress in RPE cell in vitro. AU - Honda, Shigeru. AU - Hjelmeland, Leonard M. AU - Handa, James T.. PY - 2001. Y1 - 2001. N2 - Purpose: To establish a model of mild and chronic oxidative stress using hyperoxia for retinal pigment epithelial (RPE) cells in vitro. Methods: RPE340 cells and WI38 lung fibroblasts were grown in normal oxygen (20% O2) and hyperoxia (40% O2 or 60% O2). After cell viability was examined, the levels of reactive oxygen intermediates (ROI) by flow cytometry and heme oxygenase-1 (HO-1) mRNA by northern analysis were measured as markers of oxidative stress in both cell types. Proliferative ability and gene expression pattern of growth factors were studied to demonstrate the phenotypic changes induced by mild oxidative stress upon these cells. Results: While decreased by 60% O2, 40% O2 did not affect viability in both cell types, ROI production and HO-1 mRNA expression were elevated in hyperoxia compared to ...
Markovitch, D., Tyrrell, R. M. and Thompson, D., 2005. Heme oxygenase-1 expression in human lymphocytes and resistance to oxidative stress following exercise. FASEB Journal, 19 (4), A131-A131.. ...
This is a phase II intervention to propose a new melanoma chemoprevention agent. The investigators believe oxidative stress/damage in nevi is a probable indication for melanoma risk, and propose that reduced melanoma risk in humans can be inferred by protection of nevi from ultraviolet light (UV)-induced oxidative changes. The investigators will 1) evaluate whether administration of NAC around the time of UV exposure will reduce melanoma risk in high-risk patient populations with genetic susceptibility to UV-induced oxidative stress, and 2) examine key genetic variants that will identify which individuals are most likely to benefit from chemoprotection ...
Impairment of in vitro embryonic development with a corresponding ele-vation of oxidative stress following nicotine treatment in mice: Effect of variation in treatment duration, Ka
TY - JOUR. T1 - Reduced coupling of oxidative phosphorylation In Vivo precedes electron transport chain defects due to mild oxidative stress in mice. AU - Siegel, Michael P.. AU - Kruse, Shane E.. AU - Knowels, Gary. AU - Salmon, Adam. AU - Beyer, Richard. AU - Xie, Hui. AU - van Remmen, Holly. AU - Smith, Steven R.. AU - Marcinek, David J.. PY - 2011/11/22. Y1 - 2011/11/22. N2 - Oxidative stress and mitochondrial function are at the core of many degenerative conditions. However, the interaction between oxidative stress and in vivo mitochondrial function is unclear. We used both pharmacological (2 week paraquat (PQ) treatment of wild type mice) and transgenic (mice lacking Cu, Zn-superoxide dismutase (SOD1 -/-)) models to test the effect of oxidative stress on in vivo mitochondrial function in skeletal muscle. Magnetic resonance and optical spectroscopy were used to measure mitochondrial ATP and oxygen fluxes and cell energetic state. In both models of oxidative stress, coupling of oxidative ...
TY - JOUR. T1 - Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus. AU - Labinskyy, Nazar. AU - Mukhopadhyay, Partha. AU - Toth, Janos. AU - Szalai, Gabor. AU - Veres, Monika. AU - Losonczy, Gyorgy. AU - Pinto, John T.. AU - Pacher, Pal. AU - Ballabh, Praveen. AU - Podlutsky, Andrej. AU - Austad, Steven N.. AU - Csiszar, Anna. AU - Ungvari, Zoltan. PY - 2009/4/1. Y1 - 2009/4/1. N2 - Vascular aging is characterized by increased oxidative stress and proinflammatory pheno- typic alterations. Metabolic stress, such as hyperglycemia in diabetes, is known to increase the production of ROS and promote inflammatory gene expression, accelerating vascular aging. The oxidative stress hypothesis of aging predicts that vascular cells of long-lived species exhibit lower steady-state production of ROS and/or superior resistance to the prooxidant effects of metabolic stress. We tested this hypothesis using ...
The pathogenesis of hepatic encephalopathy (HE) is multifactorial and often associated with the development of brain oedema. In addition to ammonia playing a central role, systemic oxidative stress is believed to aggravate the neuropsychological effects of ammonia in patients with chronic liver disease (CLD). The aim of this study was to (i) induce systemic oxidative stress in hyperammonaemic portacaval anastomosed (PCA) rats by inhibiting the antioxidant glutathione using Dimethyl maleate (DEM) and (ii) investigate whether a synergistic relationship between ammonia and oxidative stress contributes to the pathogenesis of brain oedema in CLD. ...
BioAssay record AID 704663 submitted by ChEMBL: Antioxidant activity in tetracycline-removed human MC65 cells assessed as suppression of oxidative stress at 0.1 uM after 48 hrs by DCFH-DA assay.
Objective: To investigate the role of oxidative stress and antioxidants in depression. Data Sources: We searched the literature without language restrictions through MEDLINE/PubMed, Cochrane Library, Fisterra, and Galenicom from database inception until December 31, 2013, supplemented by a hand search of relevant articles. Search terms included (1) oxidative stress, antioxidant*, nitrosative stress, nitrative stress, nitro-oxidative stress, free radical*, and names of individual oxidative stress markers/antioxidants and (2) depression and related disorders and antidepressant. Study Selection: Included were studies in patients with depression comparing antioxidant or oxidative stress markers with those in healthy controls before and after antidepressant treatment. Data Extraction: Two authors independently extracted the data for antioxidant or oxidative stress markers. Standardized mean differences (SMDs) +/- 95% confidence intervals (CIs) for results from |= 3 studies were calculated. Data Synthesis:
The renoprotective mechanisms of hemeoxygenase-1 (HO-1) in diabetic nephropathy remain to be investigated. We hypothesize that HO-1 protects the kidney from diabetic insult via lowering renal oxidative stress and inflammation. We used control and diabetic SHR with or without HO-1 inducer cobalt protoporphyrin (CoPP) treatment for 6 weeks. Urinary albumin excretion levels were significantly elevated in diabetic SHR compared to control and CoPP significantly attenuated albumin excretion. Immuno-histochemical analysis revealed an elevation in TGF-β staining together with increased urinary collagen excretion in diabetic versus control SHR, both of which were reduced with CoPP treatment. Renal oxidative stress markers were greater in diabetic SHR and reduced with CoPP treatment. The increase in renal oxidative stress was associated with an elevation in renal inflammation in diabetic SHR. CoPP treatment also significantly attenuated the markers of renal inflammation in diabetic SHR. In vitro inhibition of HO
Neuronal Cell Protective Effect of Dendropanax morbifera Extract against High Glucose-Induced Oxidative Stress - Dendropanax morbifera;antioxidant;oxidative stress;high glucose;neuroprotective effect;
In the pathogenesis of renal fibrosis, oxidative stress (OS) enhances the production of reactive oxygen species (ROS) leading to sustained cell growth, inflammation, excessive tissue remodelling and accumulation, which results in the development and acceleration of renal damage. In our previous work (128) we established protein DJ-1 (PARK7) as an important ROS scavenger and key player in renal cell response to OS. In the present study we investigated the impact of profibrogenic agonists on DJ-1 and shed light on the role of this protein in renal fibrosis. Treatment of renal fibroblasts and epithelial cells with the profibrogenic agonist ANG II or PDGF resulted in a significant up-regulation of DJ-1 expression parallel to an increase in the expression of fibrosis markers. Monitoring of DJ-1 expression in kidney extract and tissue sections from renal fibrosis mice model (Col4a3-deficient) revealed a disease grad dependent regulation of the protein. Overexpression of DJ-1 prompted cell resistance ...
The nuclear factor E2-related factor 2 (Nrf2) plays an important role in cellular protection against cancer, renal, pulmonary, cardiovascular and neurodegenerative diseases where oxidative stress and inflammation are common conditions. The Nrf2 regulates the expression of detoxifying enzymes by reco …
Cells, particularly mechano-sensitive musculoskeletal cells such as tenocytes, routinely encounter oxidative stress. Oxidative stress can not only stimulate tissue repair, but also cause damage leading to tissue degeneration. As diabetes is associated with increased oxidative damage as well as increased risk of tendon degeneration, the aim of this study was to determine if extracellular glucose levels alter the response of tendon cells to oxidative stress. Primary human tenocytes were cultured in either high (17.5 mM) or low (5 mM) glucose and treated with 100 μM hydrogen peroxide. In low glucose, peroxide-treated cells remained fully viable and collagen synthesis was increased, suggesting an anabolic response. In high glucose, however, peroxide treatment led to increased bim-mediated apoptosis. The activities of both forkhead box O (FOXO1) and p53 were required for upregulation of bim RNA expression in high glucose. We found that both p53-mediated inhibition of the bim repressor micro RNA (miR17-92)
Fingerprint Dive into the research topics of Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus. Together they form a unique fingerprint. ...
There was a statistically significant difference in oxidative stress status between men and women who were CAD(−) (−0.424 ± 1.3 vs. 0.64 ± 1.1 arbitrary units, respectively), but the CAD(+) women had oxidative stress levels almost three times those of the CAD(+) men (2.45 ± 2.5 vs. 0.9 ± 1.6 arbitrary units, respectively). After adjustment in the multivariate model, age and oxidative stress status in women and diabetes and age in men remained as statistically significant predictors of positive CAD findings.. Conclusion(s): ...
Oxidative stress biomarkers, in vivo heart rate (f(H)), and contraction dynamics of ventricle strips of bullfrog (Lithobates catesbeiana) tadpoles were evaluated after 48 h of exposure to a sub-lethal concentration (1 ppm) of the herbicide Roundup Original (R) (glyphosate 41%). The activities of the antioxidant enzymes superoxide dismutase and catalase were increased in the liver and decreased in muscle, while oxidative damage to lipids increased above control values in both tissues, showing that the generation of reactive oxygen species and oxidative stress are involved in the toxicity induced by Roundup (R). Additionally, tadpoles hyperactivity was associated with tachycardia in vivo, probably due to a stress-induced adrenergic stimulation. Ventricle strips of Roundup (R)-exposed tadpoles (R-group) presented a faster relaxation and also a higher cardiac pumping capacity at the in vivo contraction frequency, indicating that bullfrog tadpoles were able to perform cardiac mechanistic adjustments ...
Title:Peripherally Located A431 Cells are More Sensitive to Cell Death Induced by Exogenous Oxidative Stress. VOLUME: 7 ISSUE: 3. Author(s):Ferda Ari, Mehmet Sarimahmut and Engin Ulukaya. Affiliation:Medical School of Uludag University, Department of Medical Biochemistry, 16059 Gorukle BURSA, Turkey.. Keywords:Apoptosis, cytotoxicity, F-actin, hydrogen peroxide, oxidative stress, phalloidine, epidermoid carcinoma, hydrogen peroxide, fluorescein isothiocyanate (FITC), thymidine. Abstract:The effects of hydrogen peroxide, an oxidative agent, on the growth of A431 (an epidermoid carcinoma) cell line were investigated. It was also explored that whether or not the cell localization (peripheral or central position in a cell population) would modify the cell death-inducing effect of hydrogen peroxide. Anti-growth effect of hydrogen peroxide (0.05-1mM) on cell survival was tested by the MTT viability assay while the effect of it on DNA synthesis was measured by [3H] thymidine incorporation assay. Cell ...
Hyperglycaemia-induced oxidative stress plays an important role in cardiomyocyte cell death leading to cardiac dysfunction. Autophagy is an intracellular bulk degradation process and can be induced by stressors such as nutrient depletion and acute ischemia, to promote cell survival. Oxidative stress is an important regulator of autophagy in various pathophysiological conditions such as ischemia/reperfusion injury and hypoxia. The role of autophagy in the oxidative stress tolerance of cardiac cells exposed to simultaneous hyperglycemia and hypoxia has not been studied. The aim of the present study is to determine the role of autophagy in cardiac cells in response to combined hyperglycemia and hypoxia. H9c2 rat cardiac cell lines were grown in DMEM supplemented with standard (5.6 mM), moderately high (25 mM) and high (33 mM) glucose concentrations. The cells were then exposed to hypoxia condition (1% oxygen, O2) for 24h and 48h using the hypoxia chamber. Cell viability and oxidative stress was ...
Keywords: Reactive Oxygen Species, NADPH, Ischemic strokes, cerebral ischemia, Superoxide Dismutase, Glutathione Peroxidase. Abstract: The mechanisms leading to cellular damage from ischemia-reperfusion (I/R) injury are complex and multi-factorial. Accumulating evidence suggests an important role for oxidative stress in the regulation of neuro-inflammation following stroke. Gene expression studies have revealed that the increase in oxygen radicals post-ischemia triggers the expression of a number of pro-inflammatory genes. These genes are regulated by the transcription factor, nuclear factor-kappa-B (NF-??B) which is redox-sensitive. It is hypothesised that changes in the oxidative state may modulate alterations in the neuro-inflammatory response following an I/R injury. Furthermore, NF-??B is involved in the transcriptional regulation of adhesion molecules, which play an important role in leukocyte-endothelium interactions. Recent studies have demonstrated that adhesion molecule-mediated ...
TY - JOUR. T1 - Skin fragility in obese diabetic mice. T2 - Possible involvement of elevated oxidative stress and upregulation of matrix metalloproteinases. AU - Ibuki, Ai. AU - Akase, Tomoko. AU - Nagase, Takashi. AU - Minematsu, Takeo. AU - Nakagami, Gojiro. AU - Horii, Motoko. AU - Sagara, Hiroshi. AU - Komeda, Takashi. AU - Kobayashi, Masayuki. AU - Shimada, Tsutomu. AU - Aburada, Masaki. AU - Yoshimura, Kotaro. AU - Sugama, Junko. AU - Sanada, Hiromi. PY - 2012/3. Y1 - 2012/3. N2 - The purpose of this study was to test the hypothesis that obese diabetic mice exhibit marked skin fragility, which is caused by increased oxidative stress and increased matrix metalloproteinase (MMP) gene expression in the subcutaneous adipose tissue. Scanning electron microscopy of skin samples from Tsumura-Suzuki obese diabetic (TSOD) mice revealed thinner collagen bundles, and decreased density and convolution of the collagen fibres. Furthermore, skin tensile strength measurements confirmed that the dorsal ...
This paper discusses the scientific evidence that has been collected regarding the influence of physical activity on oxidative stress. One of the bodys responses to exercise or physical activity is increased levels of free radicals. Physical activity can increase the formation of free radicals in the body thereby increasing oxidative stress. Oxidative stress is a condition that occurs because of an imbalance between the production of free radicals with antioxidant defense systems in the body. MDA (Malondialdehyde) is one of the indicators used to determine oxidative stress in humans. MDA is the result of lipid peroxidation in the body due to free radicals. Increased conditions of oxidative stress have implications for muscle damage and if it lasts in the long run will lead to various diseases such as hypertension, atherosclerosis, diabetes, heart failure, stroke, and other chronic diseases. It is recommended that the understanding of this should be understood by all sports actors, both ...
Saliva is easily obtainable for medical research and requires little effort or training for collection. Because saliva contains a variety of biological compounds, including vitamin C, malondialdehyde, amylase, and proteomes, it has been successfully used as a biospecimen for the reflection of health status. A popular topic of discussion in medical research is the potential association between oxidative stress and negative outcomes. Systemic biomarkers that represent oxidative stress can be found in saliva. It is unclear, however, if saliva is an accurate biospecimen as is blood and/or plasma. Exercise can induce oxidative stress, resulting in a trend of antioxidant supplementation to combat its assumed detriments. Vitamin C is a popular antioxidant supplement in the realm of sports and exercise. One potential avenue for evaluating exercise induced oxidative stress is through assessment of biomarkers like vitamin C and malondialdehyde in saliva. At present, limited research has been done in this ...
Reactive oxygen species are produced during anaerobic exercise mostly by Fe ions released into plasma and endothelial/muscle xanthine oxidase activation that generates uric acid (UA) as the endpoint metabolite. Paradoxically, UA is considered a major antioxidant by virtue of being able to chelate pro-oxidative iron ions. This work aimed to evaluate the relationship between UA and plasma markers of oxidative stress following the exhaustive Wingate test. Plasma samples of 17 male undergraduate students were collected before, 5 and 60 min after maximal anaerobic effort for the measurement of total iron, haem iron, UA, ferric-reducing antioxidant activity in plasma (FRAP), and malondialdehyde (MDA, biomarker of lipoperoxidation). Iron and FRAP showed similar kinetics in plasma, demonstrating an adequate pro-/antioxidant balance immediately after exercise and during the recovery period (5-60 min). Slight variations of haem iron concentrations did not support a relevant contribution of rhabdomyolysis ...
NIEHS Grant P30ES006096 An NIEHS grantee and colleagues report that biomarkers of oxidative stress are associated with hip fracture in postmenopausal women. If additional studies confirm these results, the biomarkers could help improve prediction of hip fracture, which is associated with substantial cost and a high risk of disability and death.. Oxidative stress occurs when the body insufficiently responds to reactive oxygen species. Environmental factors such as radiation and pollutants can add to the natural level of reactive oxygen species and overcome the bodys defenses. Studies in people have suggested that oxidative stress might be a risk factor for osteoporosis, but its relationship with fracture risk is poorly understood. To find out more, the researchers prospectively assessed oxidative stress by measuring fluorescent oxidation products (FlOP) in 996 women from the Nurses Health Study who were 60 or older at baseline blood collection between 1989 and 1990. FlOPs are markers of global ...
Hyperglycemia and oxidative stress are conditions directly related to the metabolic syndrome (MetS), whose prevalence is increasing worldwide. This study aimed to evaluate the effectiveness of a new weight-loss dietary pattern on improving the oxidative stress status on patients suffering MetS with hyperglycemia. Seventy-nine volunteers were randomly assigned to two low-calorie diets (−30% Energy): the control diet based on the American Health Association criteria and the RESMENA diet based on a different macronutrient distribution (30% proteins, 30% lipids, 40% carbohydrates), which was characterized by an increase of the meal frequency (seven-times/day), low glycemic load, high antioxidant capacity (TAC) and high n-3 fatty acids content. Dietary records, anthropometrical measurements, biochemical parameters and oxidative stress biomarkers were analyzed before and after the six-month-long study. The RESMENA (Metabolic Syndrome Reduction in Navarra) diet specifically reduced the android fat mass and
Not surprisingly, the body can also suffer from reductive stress which frequently goes unmentioned. Reductive stress is achieved when the concentrations of reducing agents exceeds that of oxidizing agents. This is commonly encountered with the metabolism of ethanol. It is therefore possible for Health Fanatics to overdose on anti-oxidants and push the body into reductive stress instead of the oxidative stress they are steadfastly trying to avoid. Exercise can have positive or negative effects with regard to Redox effects on the body according to how it is performed. Exercise increases oxidative stress due to metabolic processes but when exercise is undertaken on a regular basis the body up-regulates its own anti-oxidant capacity to cope with the increased demand. This improved anti-oxidant activity clearly has additional benefits when we are not exercising but are under oxidative stress in other ways. Intermittent exercise will increase the oxidative stress burden on the body but is not ...
Vision problems…. Being able to stimulate the bodys own endogenous production of glutathione is the most significant breakthrough in natural medicine that Ive seen in 3o years.. Glutathione is the bodys most important defense against free radicals, chemical toxins, radiation, heavy metals, pollution and oxidative stress.. Oxidative stress is the damage caused to our cells as the result of normal oxidative processes occurring all the time in our bodies.. If you cut an apple in half the exposed sliced parts will soon turn brown. This is an example of oxidative stress. It is the same process which causes metals to rust. A healthy body will keep the damaging effects of oxidative stress at bay. However, cells are damaged when the effects of oxidative stress overwhelm the bodys ability to protect itself.. Someone who spends too much time in the sun will have damaged skin due to the effects of free radicals and oxidative stress. In a sense, oxidative stress causes the body to rust and cause ...
Consequently, dysfunctional ATP13A2 sensitizes cells to oxidative stress, which impairs mitochondria, and induces toxicity and cell death. death. ATP13A2-mediated polyamine transport represents a conserved pathway that protects against mitochondrial oxidative stress. The combined protective impact of ATP13A2 on lysosomal health and mitochondrial oxidative stress may explain why ATP13A2 exerts potent neuroprotective effects. (strain deficient in the ATP13A2 ortholog ortholog of ATF4, causing hypersensitivity to rotenone, which was reversible with MitoTEMPO. Together, our study reveals a conserved cell protective pathway that counters mitochondrial oxidative stress via ATP13A2-mediated lysosomal spermine export. Loss-of-function mutations in (that lysosomal polyamine export by ATP13A2 effectively lowers ROS levels and promotes mitochondrial health and functionality, pointing to a lysosomal-dependent cell protective pathway that may be implicated in ATP13A2-related neurodegenerative disorders. ...
An imbalance between the production of reactive oxygen species (ROS) and the detoxification of their reactive intermediates causes oxidative stress. Cells must respond to this imbalance before the highly reactive molecules damage cellular structures, particularly DNA. Severe and prolonged oxidative stress can trigger apoptosis and necrosis. Numerous pathological conditions have an oxidative stress component, including cardiovascular diseases, neurodegenerative diseases such as Alzheimers disease, and chronic inflammation. Signaling pathways downstream of ROS detection, such as PKC, PI3K, and MAPK, phosphorylate the transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2). This transcription factor binds the antioxidant response element (ARE) within the promoters of genes encoding antioxidant enzymes and detoxifying enzymes. Key Nrf2 target genes include antioxidants such as glutathione peroxidases (GPx) and genes involved in superoxide metabolism. These genes reduce oxidative ...
TY - GEN. T1 - Changes of metabolic conditions around calving affect oxidative stress and acute phase protein in pluriparous dairy cows. AU - Trevisi, Erminio. AU - Bertoni, Giuseppe. AU - Ferrari, Annarita. AU - Sgorlon, S. AU - Guiatti, D. PY - 2011. Y1 - 2011. N2 - The study aimed te evaluate the relationships between the variation of metabolism during the post partum and the inflammatory conditions and oxidative stress in dairy cows. For this purpose, two commercial farms were selected and 30 pluriparous Friesian cows for each farm were identified on the basis of expected date of calving. Blood was sampled from cows every fortnight starting from 14 days before calving and until 70 days postpartum (7 samples). At the same time of blood sampling, fat thickness of pelvic region was measured with an ultrasound scanner equipped with a 5 MHz transducer. Blood was analysed for acute phase response (ceruloplasmin, haptoglobin, albumin aad zinc), metabolic (b-OHB, glucose, NEFA, cholesterol,urea, ...
AbstractBackground:Although oxidative stress-related diseases mostly affect neonates with extremely low birthweight, healthy preterm and term newborns may also be at risk of oxidative damage. There have been studies concerning factors that affect the level of oxidative stress biomarkers in term and
SIGNIFICANCE. Oxidative stress is considered to be an important component of various diseases. A vast number of methods have been developed and used in virtually all diseases to measure the extent and nature of oxidative stress, ranging from oxidation of DNA to proteins, lipids, and free amino acids. Recent Advances: An increased understanding of the biology behind diseases and redox biology has led to more specific and sensitive tools to measure oxidative stress markers, which are very diverse and sometimes very low in abundance.. CRITICAL ISSUES. The literature is very heterogeneous. It is often difficult to draw general conclusions on the significance of oxidative stress biomarkers, as only in a limited proportion of diseases have a range of different biomarkers been used, and different biomarkers have been used to study different diseases. In addition, biomarkers are often measured using nonspecific methods, while specific methodologies are often too sophisticated or laborious for routine ...
In certain situations, free radicals can be generated in an exaggerated manner and can injure tissues and organs by interacting with lipids, proteins, or DNA. So, oxidative stress has been implicated in a large number of human diseases. To survive, the human body has developed a complex, efficient, and highly adaptive antioxidant defense system. The eye is also protected against oxidative stress by several mechanisms involving antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD), as well as by low-molecular-weight antioxidants such as glutathion (GSH) and ascorbate.. Primary open-angle glaucoma (POAG) is a chronic, slowly progressive optic neuropathy, characterized by excavation of the optic nerve head (ONH) and a distinctive pattern of visual field (VF) defects. The disease is multifactorial in origin, so that besides more extensively investigated factors oxidative stress has also been proposed as a contributing factor in the etiology of glaucomatous optic neuropathy. ...
Oxidative stress is involved in the initiation and progression of atherosclerosis, and hyperglycemia is known to increase oxidative stress, which injures the endothelium and accelerates atherosclerosis. To clarify the relation between oxidative stress, diabetes mellitus (DM), and acute myocardial infarction (AMI), we evaluated and compared time-specific oxidative stress after AMI in patients with and without DM by simple measurement of derivatives of reactive oxygen metabolites (d-ROMs) levels as indices of reactive oxygen species production. Sixty-eight AMI patients were enrolled (34 non-DM patients and 34 DM patients). Using the FRAS4 free radical analytical system, we measured d-ROMs levels in each patient at two time points: 1 and 2 weeks after AMI onset. d-ROM levels decreased significantly between week 1 and week 2 (from 475.4 ± 119.4 U.CARR to 367.7 ± 87.9 U.CARR, p | 0.001) in the non-DM patients but did not change in the DM patients (from 463.1 ± 109.3 U.CARR to 461.7 ± 126.8 U.CARR, p = 0
The Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene products across databases. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated gene data at MGI are provided in Term Detail reports.
Alzheimers disease (AD) is a devastating neurodegenerative disorder which is thought to affect 26.6 million individuals worldwide. There is growing concern over a worldwide dementia epidemic that is predicted to develop over the coming decades. The evidence thus far suggests that increased levels of oxidative stress and vascular risk factors are two major contributors, amongst others, to AD development. The thesis aimed to investigate markers of oxidative stress in AD plasma. Moreover, the oxidative status of specific proteins was investigated using both hypothesis driven and proteomic approaches. Results presented in this thesis suggest that global plasma protein oxidation levels are not different when AD and control subjects are compared, but that individual plasma proteins are specific targets for oxidative modification in AD. The thesis explores different methodologies to assess oxidative changes in AD. In addition it demonstrates that emerging novel and powerful mass spectrometry ...
In recent years, different researchers have proposed that translational regulation is central to the response to some stress conditions, during either its initiation and/or elongation steps. However, there is controversy over some of proposed mechanisms. One of the important hostile conditions confronted by bacteria is oxidative stress. Bacteria are often exposed to various environments and anthropogenic factors that favor the production of oxidative molecules, which in some conditions can produce oxidative stress. Consequently, these microorganisms have developed mechanisms to overcome this stress at diverse environments, such as inside of macrophages from humans or other animals. For many years, the study of these mechanisms has focused on transcriptional changes triggered by the stress. However, the RNA components involved in translation are not static and also respond to changes in the cellular environment. In fact, there are examples of alterations induced by oxidative stress conditions to ...
Open access preprint on Evaluation of hemolytic activity and oxidative stress biomarkers in erythrocytes after exposure to bioactive glass nanoceramics
The Plax test is slowly gaining ground as a strong marker for CVD risk. This article further affirms this relationship and goes further, linking oxidative stress biomarkers, Plax and CVD, with almost 2.5 times the risk for CVD when both were present in the highest levels.
In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.
Abstract: After the onset of a stroke, blood flows disrupted in areas affected by vascular occlusion limit the delivery of oxygen and metabolic substrates to neurons causing ATP reduction and energy depletion. The glucose and oxygen deficit that occurs after severe vascular occlusion is the origin of the mechanisms that lead to cell death and cerebral injury caused of oxidative stress. Oxidative stress constitutes mechanism of injury of many types of disease processes. On oxidative stress occurs on the increase in ROS and RNS. This paper will discuss about cerebral ischemia that causes activation of ROS and RNS, also themechanisms that play a role in cell death after cerebral ischemia, for example the role of phospholipase, Haber-Weiss reaction, and lipid peroxidation. It is also described about anti-oxidants to fight free radicals, for examples glutathione peroxidase, catalase and superoxide dismutase. ...
The imbalance between oxidant molecules and antioxidant agents is characterized as oxidative stress (OS) and may lead to severe damage to the organism. In contrast, the physical training of aerobic and resistive character promotes increases of the antioxidant response, resulting in a balance and/or minimizing damage. Therefore, the objective of the study is to verify the effect of aerobic training, resistive training and concurrent training on oxidative stress of Wistar rats. Methods: To perform the experiment, 40 Wistar rats were subjected to eight weeks of training. The animals were distributed into 4 different groups: control, aerobic, resistive and concurrent (combination of aerobic and resistive protocols in the same section) an h/day, five days/week, for eight weeks. At the end of the experimental period: the antioxidant enzymes (catalase, glutathione peroxidase and superoxide dismutase), biomarkers of oxidative stress (TBARs and H2O2) as well as the activity of reduced and oxidized glutathione
During physiological aerobic metabolism, the epidermis undergoes significant oxidative stress as a result of the production of reactive oxygen species (ROS). To maintain a balanced oxidative state, cells have developed protective antioxidant systems, and preliminary studies suggest that the transcriptional factor p63 is involved in cellular oxidative defence. Supporting this hypothesis, the ΔNp63α isoform of p63 is expressed at high levels in the proliferative basal layer of the epidermis. Here we identify the CYGB gene as a novel transcriptional target of ΔNp63 that is involved in maintaining epidermal oxidative defence. The CYGB gene encodes cytoglobin, a member of the globin protein family, which facilitates the diffusion of oxygen through tissues and acts as a scavenger for nitric oxide or other ROS. By performing promoter activity assays and chromatin immunoprecipitation, reverse transcriptase quantitative PCR and western blotting analyses, we confirm the direct regulation of CYGB by ΔNp63α.
Free radicals are biological kleptomaniacs, and no amount of psycho-therapy is going to quell their desire to steal. In the case of skin aging, they are taking electrons. When free radicals steal electrons from other molecules, the result is damage to delicate skin components and further inflammation. Inflammation promotes oxidative stress, and oxidative stress promotes inflammation in an ongoing vicious cycle.. Oxidative Stress: When oxygen is used to produce energy in the human body, one of the byproducts is the creation of highly reactive molecules called free radicals. They are highly reactive because each of them is an unpaired molecule looking for a partner. They can interact with and damage structural fats, proteins, and even delicate genetic components in a process called oxidative stress.. The generation of free radicals is never going to stop. And approximately 3 percent of oxygen used in the metabolic processes of our cells is converted to free radicals. So why bother to worry about ...
Aging is associated with increased oxidative stress. Muscle levels of oxidative stress are further elevated with exercise. The purpose of this study was to determine if dietary antioxidant supplementation would improve muscle function and cellular markers of oxidative stress in response to chronic repetitive loading in aging. The dorsiflexors of the left limb of aged and young adult Fischer 344 Br
TY - CONF AU - Kotur-Stevuljević, Jelena AU - Spasić, S. AU - Stefanović, Aleksandra AU - Spasojević-Kalimanovska, Vesna AU - Jelić-Ivanović, Zorana PY - 2006 UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/723 PB - Savez farmaceutskih udruženja Srbije, Beograd C3 - Arhiv za farmaciju T1 - Paraoxonase status and interaction with oxidative stress parameters in patients with coronary artery disease T1 - Status paraoksonaze i interakcija sa parametrima oksidativnog stresa kod pacijenata sa koronarnom arterijskom bolešću VL - 56 IS - 5 SP - 648 EP - 649 ER ...
... has also been implicated in chronic fatigue syndrome (ME/CFS). Oxidative stress also contributes to tissue ... Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling. In humans, oxidative stress is thought ... Sies H (1985). "Oxidative stress: introductory remarks". In Sies H (ed.). Oxidative Stress. London: Academic Press. pp. 1-7. ... On the other hand, high levels of oxidative stress can also be selectively toxic to cancer cells. Oxidative stress is likely to ...
Sies, Helmut (1985). Oxidative stress. London: Orlando. p. 1-8. ISBN 9781483289113. Retrieved 17 January 2022. Sies, Helmut ( ... Sies, Helmut (September 2020). "Findings in redox biology: From H2O2 to oxidative stress". Journal of Biological Chemistry. 295 ... Sies, Helmut; Berndt, Carsten; Jones, Dean P. (20 June 2017). "Oxidative Stress". Annual Review of Biochemistry. 86 (1): 715- ... "Oxidative Stress". He found that Lycopene, a carotenoid common in tomatoes, works as an antioxidant by quenching singlet ...
Davies KJ (1995). "Oxidative stress: the paradox of aerobic life". Biochem. Soc. Symp. 61: 1-31. doi:10.1042/bss0610001. PMID ... Finkel T, Holbrook NJ (2000). "Oxidants, oxidative stress and the biology of ageing". Nature. 408 (6809): 239-47. Bibcode: ... Alternative pathways might, therefore, enhance an organisms' resistance to injury, by reducing oxidative stress. The original ... Søballe B, Poole RK (1999). "Microbial ubiquinones: multiple roles in respiration, gene regulation and oxidative stress ...
Fn mRNA in NRK-49F cells through enhancement of oxidative stress, and suggested that inhibition of oxidative stress might ... Such increases in oxidative stress lead to the activation of the transcription factor NF-κB and promote the expression of NF-κB ... Enhanced oxidative stress. Hemoglobin-AGE levels are elevated in diabetic individuals and other AGE proteins have been shown in ... Finally, AGEs can bind to RAGE (receptor for advanced glycation end products) and cause oxidative stress as well as activation ...
"What is oxidative stress? Effects on the body and how to reduce". www.medicalnewstoday.com. 2019-04-03. Retrieved 2021-05-08. v ... Problems can also arise in oxygen-rich environments, most commonly attributed to oxidative stress. This occurrence is when ... but obligate aerobes are subject to high levels of oxidative stress. Among organisms, almost all animals, most fungi, and ... "An obligately aerobic spirillum fermentative hydrogen production to survive reductive stress during hypoxia". Proceedings of ...
Bošković M, Vovk T, Kores Plesničar B, Grabnar I (June 2011). "Oxidative stress in schizophrenia". Current Neuropharmacology. 9 ... McEwen, B. S. (September 2005). "Stressed or stressed out: what is the difference?". Journal of Psychiatry and Neuroscience. 30 ... There is significant evidence that oxidative stress plays a role in schizophrenia. A number of patients, activists, and ... 2006). "Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment". Hippocampus. 16 (3): 239-49. doi: ...
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"Protection from Oxidative Stress". "Cell Death and Diseases of the Nervous System, edited by Vassilis E. Koliatsos and Rajiv R ... 2004) Mitochondria and Oxidative Stress in Neurodegenerative Disorders co-editor. (2008) Glutathione and the Regulation of ... His studies have tried to explain fundamental mechanisms by which oxidative stress triggers ferroptosis, the inappropriate ... "Cell Death and Diseases of the Nervous System". Mitochondria and Oxidative Stress in Neurodegenerative Disorders. ISBN ...
Betteridge, D. John (2000). "What is oxidative stress?". Metabolism. 49 (2): 3-8. doi:10.1016/s0026-0495(00)80077-3. PMID ... This breakdown of lignin includes an oxidative mechanism, and requires the presence of dissolved oxygen to take place by ... on Respiration and Behaviour of Stickleback Gasterosteus aculeatus and the Eelpout Zoaraes viviparus During Low Oxygen Stress ...
As telomeres shorten as a natural consequence of repeated cell division or due to other factors, such as oxidative stress, ... von Zglinicki, Thomas (July 2002). "Oxidative stress shortens telomeres". Trends in Biochemical Sciences. 27 (7): 339-344. doi: ...
A related problem for aerobic organisms is oxidative stress. Here, processes including oxidative phosphorylation and the ... Davies KJ (1995). "Oxidative stress: the paradox of aerobic life". Biochemical Society Symposium. 61: 1-31. doi:10.1042/ ... Sies H (March 1997). "Oxidative stress: oxidants and antioxidants". Experimental Physiology. 82 (2): 291-5. doi:10.1113/ ... In many organisms, the capture of solar energy is similar in principle to oxidative phosphorylation, as it involves the storage ...
Conte ML, Carroll KS (14 February 2013). "The Chemistry of Thiol Oxidation and Detection" (PDF). Oxidative Stress and Redox ... and oxidative stress. The presence of a thiol functional group allows its product GSH to serve both as an effective oxidizing ...
... oxidative stress and cardiac stress. Oxidative stress favours the development and progression of heart failure as it causes ... Tsutsui, Hiroyuki; Kinugawa, Shintaro; Matsushima, Shouji (December 2011). "Oxidative stress and heart failure". American ... Periodontitis may be associated with higher stress. Periodontitis occurs more often in people from the lower end of the ... "A systematic review of stress and psychological factors as possible risk factors for periodontal disease". Journal of ...
Toyokuni S, Okamoto K, Yodoi J, Hiai H (1995). "Persistent oxidative stress in cancer". FEBS Lett. 358 (1): 1-3. doi:10.1016/ ... Several studies have linked oxidative stress to diseases such as Alzheimer's disease, as well as cancer, These studies have ... Palmer AM (1999). "The activity of the pentose phosphate pathway is increased in response to oxidative stress in Alzheimer's ... Palmer AM (1999). "The activity of the pentose phosphate pathway is increased in response to oxidative stress in Alzheimer's ...
Davies KJ (1995). "Oxidative stress: the paradox of aerobic life". Biochemical Society Symposium. 61: 1-31. doi:10.1042/ ... Vieira Dos Santos C, Rey P (July 2006). "Plant thioredoxins are key actors in the oxidative stress response". Trends in Plant ... Finkel T, Holbrook NJ (November 2000). "Oxidants, oxidative stress and the biology of ageing". Nature. 408 (6809): 239-47. ... Glantzounis GK, Tsimoyiannis EC, Kappas AM, Galaris DA (2005). "Uric acid and oxidative stress". Current Pharmaceutical Design ...
... oxidative stress Physical exercise intensity exhibits a hormetic curve regarding oxidative stress levels. Individuals with low ... Small amounts of oxidative stress may be beneficial. Mitochondria are sometimes described as "cellular power plants" because ... This would imply that oxidative stress, itself, provides an example of hormesis (see section on Mitochondrial hormesis), but ... Radak, Zsolt; Chung, Hae Y.; Koltai, Erika; Taylor, Albert W.; Goto, Sataro (2008). "Exercise, oxidative stress and hormesis". ...
Holguin F, Fitzpatrick A (March 2010). "Obesity, asthma, and oxidative stress". Journal of Applied Physiology. 108 (3): 754-9. ... Psychological stress may worsen symptoms - it is thought that stress alters the immune system and thus increases the airway ... Maternal psychological stress during pregnancy is a risk factor for the child to develop asthma. Asthma is associated with ... Chen E, Miller GE (November 2007). "Stress and inflammation in exacerbations of asthma". Brain, Behavior, and Immunity. 21 (8 ...
The oxidative stress produced by these chemicals can damage cells and tissues, for example an overdose of the analgesic ... Han SG, Kim Y, Kashon ML, Pack DL, Castranova V, Vallyathan V (December 2005). "Correlates of oxidative stress and free-radical ... It may be that oxidative stress produced by such agents mimics a normal physiological signal for fibroblast conversion to ... Valko M, Morris H, Cronin MT (2005). "Metals, toxicity and oxidative stress". Curr. Med. Chem. 12 (10): 1161-208. doi:10.2174/ ...
Sies H (March 1997). "Oxidative stress: oxidants and antioxidants". Exp. Physiol. 82 (2): 291-5. doi:10.1113/expphysiol.1997. ... These oxidative reactions typically involve a cytochrome P450 monooxygenase (often abbreviated CYP), NADPH and oxygen. The ... these are major characteristics of xenobiotic toxic stress. The major challenge faced by xenobiotic detoxification systems is ...
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Oxidative Stress and Neurodegenerative Disorders. Elsevier Science B.V.: 369-382. doi:10.1016/B978-044452809-4/50157-5. ISBN ...
Oxidative Stress in Aquatic Ecosystems. Wiley-Blackwell. 2011. ISBN 978-1-4443-3548-4. Abele, Doris (2007). "Impact of climate ... She led the research group working on stress physiology and aging in marine invertebrates and also the Ecology Polar regions ...
Smoking results in generation of huge amount of reactive oxygen species leading to increased oxidative stress culminating into ... Trueb, Ralph M (2009). "Oxidative stress in ageing of hair". International Journal of Trichology. 1 (1): 6-14. doi:10.4103/0974 ... If the cause is due to melanocyte stem cell interruption during the growth cycles due to stress or illness then the use of ... Stress causing over-activation of the sympathetic nervous system increases noradrenaline release in hair follicles. This ...
Advanced Protocols in Oxidative Stress II. Methods in Molecular Biology. Vol. 594. pp. 251-62. doi:10.1007/978-1-60761-411-1_17 ... Antioxidants are considered to protect the fluorescent molecule from the oxidative degeneration. The degree of protection is ... The assay measures the oxidative degradation of the fluorescent molecule (either beta-phycoerythrin or fluorescein) after being ... proteins and lipids from oxidative damage pursuant to Article 13(1) of Regulation (EC) No 1924/20061". EFSA Journal. 8 (2): ...
Diabetic humans show increased oxidative stress. 3DG-induced ROS result in oxidative DNA damage. 3DG can be internalized by ... Araki A (September 1997). "[Oxidative stress and diabetes mellitus: a possible role of alpha-dicarbonyl compounds in free ... "Involvement of glycation and oxidative stress in diabetic macroangiopathy". Diabetes. 45 Suppl 3: S81-3. doi:10.2337/diab.45.3. ... "Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress". Diabetes. 54 (11): 3274-81. doi:10.2337/ ...
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Hemopexin prevents haem-mediated oxidative stress. Structurally hemopexin consists of two similar halves of approximately two ...
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Valko M, Morris H, Cronin MT (2005). "Metals, toxicity and oxidative stress" (PDF). Current Medicinal Chemistry. 12 (10): 1161- ... Bacteria - some bacteria such as Helicobacter pylori cause inflammation during which oxidative species are produced, causing ...
Ralph M Trüeb (Jan-Jun 2009). "Oxidative Stress in Ageing of Hair". Int J Trichology. 1 (1): 6-14. doi:10.4103/0974-7753.51923 ... "The Effects of Stress on Your Hair". Web MD. Retrieved 14 August 2013. Ballantyne, Coco. "Fact or Fiction?: Stress Causes Grey ... which breaks down hydrogen peroxide and relieves oxidative stress in patients with vitiligo. Since vitiligo can cause eyelashes ... Anecdotes report that stress, both chronic and acute, may induce achromotrichia earlier in individuals than it otherwise would ...
It was shown that Daxx associates with Pml only when exposed to high oxidative stress or UV-irradiation. Another study showed ... This pathway normally regulates stress-induced cell death. It is also essential for development of nerval system by programmed ... "Dualistic function of Daxx at centromeric and pericentromeric heterochromatin in normal and stress conditions". Nucleus. 3 (3 ...
Additionally, inbred males have elevated testicular oxidative stress which may underlie their reduced fertility. Jallon, Jean- ... Male attractiveness, fertility and susceptibility to oxidative stress are influenced by inbreeding in Drosophila simulans. J ...
... in aging and obesity was shown to contribute to the development of insulin resistance and may promote oxidative stress. ... 2004). "NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic ... Nox4 protects the vasculature against inflammatory stress. Nox-dependent reactive oxygen species modulation by amino ...
Indeed, this ray might experience greater salinity-induced oxidative stress in freshwater than in brackish water, possibly ... the ability of these elasmobranchs to increase the capacity of ascorbic acid synthesis to defend against hyposalinity stress. ...
... subsequently producing oxidative stress and cell cycle arrest. Fluoride overload is suggested to be linked to pH and ... Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis". International Journal of Molecular Sciences. 22 (21 ...
Cao C, Leng Y, Kufe D (August 2003). "Catalase activity is regulated by c-Abl and Arg in the oxidative stress response". J. ... "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 ... Shaul Y, Ben-Yehoyada M (2005). "Role of c-Abl in the DNA damage stress response". Cell Res. 15 (1): 33-5. doi:10.1038/sj.cr. ... Wen ST, Van Etten RA (October 1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3 ...
This is also known as oxidative stress. There is substantial evidence to back up this theory. Old animals have larger amounts ... This report suggests that DNA damage, not oxidative stress, is the cause of this form of accelerated aging. Ageing Aging brain ... These processes termed oxidative stress are linked to the potential benefits of dietary polyphenol antioxidants, for example in ... Holmes GE, Bernstein C, Bernstein H (September 1992). "Oxidative and other DNA damages as the basis of aging: a review". Mutat ...
At higher levels, they can lead to oxidative stress, which has been implicated in a wide range of human diseases. Winterbourne ...
Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma ...
... against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and ...
"Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications". Oxidative Medicine and ... higher levels of reactive oxygen species and increased oxidative stress. Mutant huntingtin protein promotes oxidative damage to ... "The naked mole-rat response to oxidative stress: just deal with it". Antioxidants & Redox Signaling. 19 (12): 1388-99. doi: ... a view through the oxidative stress looking-glass". Neuroscience Bulletin. 30 (2): 243-52. doi:10.1007/s12264-013-1424-x. PMC ...
Blass, 'Mitochondria and Oxidative Stress in Neurodegenerative Disorders', which was also a satellite meeting of the ... Blass, 'Mitochondria and Oxidative Stress in Neurodegenerative Disorders' http://www.nyas.org/Events/Detail.aspx?cid=8a0f4c49- ... Oxidative/Energy Metabolism in Neurodegenerative Disorders (with Fletcher H. McDowell, 1999, New York Academy of Sciences, ISBN ... where he described the first hereditary defect in a major enzyme of human oxidative/energy metabolism, pyruvate dehydrogenase ...
... as to how varicocele affects sperm function include damage via excess heat caused by the blood pooling and oxidative stress on ...
... and the increase in the endogenous anti-oxidant ubiquinone an attempt to protect the brain from oxidative stress, for instance ...
SorX is the second 1O2 induced sRNA that counteracts oxidative stress by targeting mRNA for a transporter. It also has an ... sRNAs called CcsR for conserved CCUCCUCCC motif stress-induced RNA has been shown to play a role in photo-oxidative stress ... One of the 1O2 induced sRNAs SorY (1O2 resistance RNA Y) was shown to be induced under several stress conditions and conferred ... Berghoff, Bork A.; Glaeser, Jens; Sharma, Cynthia M.; Vogel, Jörg; Klug, Gabriele (2009-12-01). "Photooxidative stress-induced ...
MacKenzie EL, Ray PD, Tsuji Y (2008). "Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress". ... 2009). "Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective ...
"Effect of sibling competition and male carotenoid supply on offspring condition and oxidative stress" Ricklefs, Robert E.; " ...
However, heat shock and other stresses changes the equilibrium between oxidative stress and antioxidant activity, for example, ... Chemi-excitation via oxidative stress by reactive oxygen species and/or catalysis by enzymes (i.e., peroxidase, lipoxygenase) ... One biophoton mechanism focuses on injured cells that are under higher levels of oxidative stress, which is one source of light ... Ursini F, Barsacchi R, Pelosi G, Benassi A (July 1989). "Oxidative stress in the rat heart, studies on low-level ...
Thus, NADK can modulate responses to oxidative stress by controlling NADP synthesis. Bacterial NADK is shown to be inhibited ... "Evidence that feedback inhibition of NAD kinase controls responses to oxidative stress". Proceedings of the National Academy of ... "Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy". Molecular ... Oxidative phosphorylation Electron transport chain Metabolism PDB: 1SUW​; Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH (Nov ...
In particular, when concerning host defense, manganese acts as a preventative measure for oxidative stress by destroying free ... Wang M, Zheng Q, Shen Q, Guo S (April 2013). "The critical role of potassium in plant stress response". International Journal ...
Wall SB, Oh JY, Diers AR, Landar A (2012). "Oxidative modification of proteins: an emerging mechanism of cell signaling". ... and stress-induced central nervous system trauma. Rat Cerebral cortex neurons and human neuroblastoma SH-SY5Y cells become ... to sequester in cellular stress granules. The inhibition of protein translation can trigger programmed cell death responses ...
... is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain. In ... "Evidence that brain tissue volumes are associated with HVA reactivity to metabolic stress in schizophrenia". Schizophr. Res. 86 ... psychiatry and neuroscience, brain and cerebrospinal fluid levels of HVA are measured as a marker of metabolic stress caused by ...
Oxidative stress accompanied by a low-grade inflammatory response appears to aggravate cardiovascular morbidity. Rheumatic ... Experimental data demonstrate that Se treatment modifies brain Hg retention, modulates neurotoxicity and oxidative stress in ...
This reduces oxidative stress on cells, formation of cytotoxic products of fatty acid oxidation and subsequent cellular damage ... to survive ischemic stress conditions. This is done by adapting myocardial cells to lower fatty acid inflow and by activating ... protection against stress, and enhanced activation of central nervous system (CNS) functions". However the study itself ... who studies how humans respond to physical and mental stress during exercise and other activities, told them that "Evidence is ...
Plant Symposium of the SEB: Oxidative stress and cell death in plants: mechanisms and implications, Florence, Italy, 26-28 June ... Y(II) can be more sensitive to some types of plant stress than FV/FM, such as heat stress. Other plant mechanism measuring ... Chlorophyll fluorescence can be used as a proxy of plant stress because environmental stresses, e.g. extremes of temperature, ... studied heat stress in wheat plants and found that temperature stability in the Photosystem II of water-stressed leaves ...
... and examining the possible role of the pigment in protecting the cell from oxidative stress damage. One outcome of this work ... The production of this pigment in Haematococcus Pluvialis is enhanced due to various environmental stresses which limit the ... then the biomass is subjected to stress conditions such as high light or nutrient deprivation. One of the main challenges in ...
Altuvia, S., Weinstein-Fischer, D., Zhang, A., Postow, L., and Storz, G. (1997) A small, stable RNA induced by oxidative stress ... Storz, G., Tartaglia, L. A., and Ames, B. N. (1990) Transcriptional regulator of oxidative stress-inducible genes: Direct ... "The Science of Stress". Storz, Gisela. "Lab website". "NICHD 2016 Annual Report of the Division of Intramural Research, Storz ... her research was the study of redox-sensitive transcription factors and the bacterial and yeast responses to oxidative stress. ...
"Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress". The ... Cells sense extracellular oxidative stimuli to decrease G6PD acetylation in a SIRT2-dependent manner. The SIRT2-mediated ... and oxidant stress". FASEB Journal. 8 (2): 174-81. doi:10.1096/fasebj.8.2.8119488. PMID 8119488. S2CID 38768580. de Lartigue J ... The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative ...
... defence against oxidative stress and redox signalling in all living cells from bacteria to nerve cells. His work remains of ...
As temperatures starts to rise, so do voices warning about the ...
Metabolism and oxidative stress in the brain. The idea behind the study was that the brain itself - like all tissues in our ... What is oxidative stress? As cells "eat" various molecules for fuel, they produce a number of toxic waste products in the form ... Physical sciences/Chemistry/Chemical processes/Redox processes/Oxidative stress * /Physical sciences/Chemistry/Molecular ... But that battle is ongoing, sometimes that balance is disturbed and that disturbance thats what we call "oxidative stress". ...
Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells.pdf. Sirt1 Inhibits Oxidative Stress in Vascular Endothelial ... Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells.pdf. Sirt1 Inhibits Oxidative Stress in Vascular Endothelial ... Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells. *May 2017. *Oxidative Medicine and Cellular Longevity 2017(2):1- ... interplay between reactive stress and Sirt1. Sirt1 has gained a. lot of attention for its role in oxidative stress resistance. ...
Analysis of oxidative stress levels in people who meditate indicated that meditation correlates with lower oxidative stress ... The consequence is a lower level of oxidative stress, which suggests that an appropriate diaphragmatic breathing could protect ... breathing on exercise-induced oxidative stress and the putative role of cortisol and melatonin hormones in this stress pathway ... Diaphragmatic breathing is relaxing and therapeutic, reduces stress, and is a fundamental procedure of Pranayama Yoga, Zen, ...
We investigated whether RWE (red wine extract) prevents oxidative-stress-induced senescence in HUVECs (human umbilical-vein ... Red wine extract protects against oxidative-stress-induced endothelial senescence Clin Sci (Lond). 2012 Oct;123(8):499-507. doi ... We investigated whether RWE (red wine extract) prevents oxidative-stress-induced senescence in HUVECs (human umbilical-vein ...
Informal Discussion on Oxidative Stress in Chernobyl Accident Recovery Workers (‎1996: Paris, France)‎; World Health ... Accident Recovery Workers Project : report of the Informal Discussion on Oxidative Stress in Chernobyl Accident Recovery ...
... on H2O2-induced Oxidative Stress in Isolated Rat Hearts Publication Journal of Ethnopharmacology, Vol. 56, pp. 215-222, 1997. ... Effect of Maharishi AK-4 [MAK-4] on H2O2-induced Oxidative Stress in Isolated Rat Hearts. Publication. Journal of ... Using hydrogen peroxide (H2O2) as a model pro-oxidant to induce oxidative stress, we have examined the ability of the natural ... However, addition of MAK-4 in the perfusate containing H2O2 decreased oxidative stress in terms of release of LDH and ...
A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes Jay C. Jha; Jay C ... Jay C. Jha, Florence Ho, Christopher Dan, Karin Jandeleit-Dahm; A causal link between oxidative stress and inflammation in ... Chronic renal and vascular oxidative stress in association with an enhanced inflammatory burden are determinant processes in ... mediators of inflammation as well as suppresses antioxidant defence mechanisms ultimately contributing to oxidative stress ...
... * The two main reasons cows get culled are health issues ending in poor performance and reproductive ... Nutrition plays a critical role in keeping a cow in oxidative balance, maintaining a cows immune system and keeping them ... Antioxidants can help keep free radicals in check and maintain the oxidative status in the cow. Amino acids, antioxidants, and ... keeping a cows system in better oxidative balance. ...
We observed oxidative stress accumulation and an engagement of microRNAs (miRNAs) in the aging heart. MiRNA-sequencing of 5 ... we analyzed oxidative stress levels in cardiac sections derived from young, adult and old Nfus. The oxidative stress damage was ... Oxidative stress and epigenetic regulation in ageing and age-related diseases. International journal of molecular sciences 14, ... Oxidative stress accumulates in the aging heart of Nothobranchius furzeri Currently, little is known regarding Nfu heart as ...
Infertility, oxidative stress and vitamin C.. Vitamin C (L-ascorbic acid, ascorbate) has long been associated with fertility. ... Because oxidative stress in the testis is one of the major factors that induces germ cell apoptosis, this organ has high ... KASAHARA E, SATO EF, MIYOSHI M, KONAKA R, HIRAMOTO K, SASAKI J, TOKUDA M, NAKANO Y, INOUE M (2002) Role of oxidative stress in ... AITKEN RJ, GORDON E, HARKISS D, TWIGG JP, MILNE P, JENNINGS Z, IRVINE DS (1998) Relative impact of oxidative stress on the ...
Researchers have discovered the system used by plants to prevent oxidative stress and to safely carry out photosynthesis. ... How plants prevent oxidative stress. by Kobe University Reactive oxygen species production and regulation mechanism. Credit: ... Researchers have discovered the system used by plants to prevent oxidative stress and to safely carry out photosynthesis. ... Building on these results, they developed the "pulse method" to artificially induce oxidative stress. They discovered the P700 ...
Turmeric reduces oxidative stress and attenuates aortic fatty streak development in rabbits. ... Turmeric reduces oxidative stress and attenuates aortic fatty streak development in rabbits. - GreenMedInfo Summary ... CONCLUSIONS: Supplementation with Curcuma longa reduces oxidative stress and attenuates the development of fatty streaks in ... Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. ...
Sumoylation is a downstream effector of aging/oxidative stress; excess oxidative stress leads to dysregulation of a specificity ... Sumoylation is a downstream effector of aging/oxidative stress; excess oxidative stress leads to dysregulation of a specificity ... which share oxidative stress and inflammation as pivotal players. It is evident that oxidative stress and inflammation have ... Aging is an oxidative stress-associated process that progresses with age. Our aim is to delay or attenuate these oxidative ...
Oxidative stress markers [ Time Frame: 6-8 weeks ]. Change in baseline urine markers of stress (iPF2-Alpha-III/creat; iPF2- ... Blood Pressure and Oxidative Stress Official Title ICMJE Effect of Pterostilbene on Cholesterol, Blood Pressure and Oxidative ... Effect of Pterostilbene on Cholesterol, Blood Pressure and Oxidative Stress. The safety and scientific validity of this study ... and oxidative stress. The purpose of this study is to evaluate whether pterostilbene will help control cholesterol and blood ...
All three indices of oxidative stress used showed an effect of flight exercise. There was no difference in escape time on ... Using a captive population of wild-type budgerigars, I assessed the role of exercise training on oxidative stress. I found that ... Of particular note, was the fact that three different measures of oxidative stress carried out for each individual did not ... I assessed individual differences in oxidative stress and take-off escape time in birds following both an enhanced or reduced ...
The current review examined the role of oxidative stress in AD.. Introduction. Oxidative stress, a process increased in the ... Oxidative stress. Oxidative stress encompasses a variety of molecules and free radicals deriving from molecular oxygen. These ... Role of oxidative stress in Alzheimers disease. The brain of patients suffering AD present a significant extent of oxidative ... This is a significant role for oxidative brain in AD since the brain is vulnerable to oxidative stress. However, multicenter ...
Informal Discussion on Oxidative Stress in Chernobyl Accident Recovery Workers (‎1996: Paris, France)‎, World Health ... 1997)‎. Accident Recovery Workers Project : report of the Informal Discussion on Oxidative Stress in Chernobyl Accident ... Accident Recovery Workers Project : report of the Informal Discussion on Oxidative Stress in Chernobyl Accident Recovery ...
The relationship between oxidative stress and lower urinary tract symptoms: Results from the community health survey in Japan. ... Higher levels of an oxidative stress biomarker have been found in men and women with nocturia, researchers reported in BJU ... our observation supports the negative effect of deteriorated general health status via oxidative stress on nocturia," Dr ... and collaborators examined several indicators of oxidative stress and their relationship with lower urinary tracts symptoms ( ...
In response, aerobic organisms created defense mechanisms to avoid oxidative stress. Oxidative stress has recently become the ... DNA Damage by Oxidative Stress. Oxidative damage to DNA results from the interaction of DNA with ROS, in particular, hydroxy ... Oxidative Stress. Stress Maker Detection /NO Detection /NO Donor /NO Inhibitor /ACE Inhibition Assay /Reagents・Kits for Sulfur ... Stress Marker Detection. DPPP 10 mg D535. Stress Marker Detection. 3-Deoxyglucosone 1 mg DK02. NO Detection. -Nucleostain- DNA ...
The terms oxidative stress and free radicals have become familiar in recent years. What do they mean? ... Stumped By Oxidative Stress?. Can you please explain oxidative stress to me? Also, I really dont understand what free radicals ... The terms oxidative stress and free radicals have become familiar in recent years, but Im sure youre not the only one who ... Oxidative stress is the total burden placed on organisms by the constant production of free radicals in the normal course of ...
Nft Compensatory Against Oxidative Stress - Click here for more information. Find everything you need to know about OpenSea ... Nft Compensatory Against Oxidative Stress. To know more about it to learn more, check out their FAQs to get the steps you can ... Nft Compensatory Against Oxidative Stress. You can swap the fiat currency you have with a the credit card, or Paypal via these ... Frequently Asked Questions Nft Compensatory Against Oxidative Stress. What is OpenSea?. OpenSea is an NFT marketplace that aims ...
... oxidative stress and metal-dependent nutritional immunity.. Source: RsaC sRNA modulates the oxidative stress response of ... In addition, other putative targets of RsaC are involved in oxidative stress (ROS and NOS) and metal homeostasis (Fe and Zn). ... SodA is a Mn-dependent superoxide dismutase involved in oxidative stress response. Remarkably, rsaC gene is co-transcribed with ... RsaC sRNA modulates the oxidative stress response of Staphylococcus aureus duri…. *Centre international de recherche en ...
Is oxidative stress a physiological cost of reproduction. Keywords: Hurst, Stockley, rodents, life history strategy, ... Garratt, M., Vasilaki, A., Stockley, P. McArdle, F., Jackson, M. & Hurst, J.L. (2011) Is oxidative stress a physiological cost ... Is oxidative stress a physiological cost of reproduction? An experimental test in house mice ... Female mice can limit oxidative stress during reproduction. Posted on: 1 February 2011 in 2011 ...
Evidence of increased cell membrane damage and oxidative stress in the cell cultures was identified. Oxidative stress ... Swiss team finds particle emissions from aircraft turbine engines at ground-idle induce oxidative stress in bronchial cells 17 ... "Non-volatile particle emissions from aircraft turbine engines at ground-idle induce oxidative stress in bronchial cells," ...
Fluoride & Oxidative Stress. A vast body of research demonstrates that fluoride exposure increases oxidative stress. Based on ... Vitamin A deficiency: An oxidative stress marker in sodium fluoride (NaF) induced oxidative damage in developing rat brain. ... Categories: Brain, Brain Cellular/Tissue Effects, Cognitive Function, Mechanisms of Cellular Toxicity, Oxidative Stress, * ... Fluoride induced oxidative stress through depletion in levels of various anti-oxidants such as glutathione, superoxide ...
Oxidative stress in carotid arteries of patients submitted to carotid endarterectomy. The role of aging process1 1 Research ... Oxidative stress parameters are demonstrated in the Figure 1 (A-E). In the older patients, we observed a higher levels of ROS ... Arterial oxidative stress develops with aging as a consequence of excessive production of •O2 - by NADPH oxidase mainly2020. ... Oxidative stress, defined as an imbalance between oxidants and antioxidants in favor of the former, plays a significant role in ...
We found that FAIM counteracts heat and oxidative stress-induced loss of cell viability. FAIM is recruited to ubiquitinated ... Administration of a mediator of oxidative stress to FAIM-deficient animals induced more ubiquitinated protein aggregates and ... Administration of a mediator of oxidative stress to FAIM-deficient animals induced more ubiquitinated protein aggregates and ... FAIM is recruited to ubiquitinated proteins induced by cellular stress and the levels of stress-induced protein aggregates are ...
A single time vaping increases oxidative stress levels up to four times in non-smokers. ... They found that in nonsmokers, oxidative stress levels were two to four times higher after the vaping session than before. The ... There is still more to be understood about what exactly causes the changes in oxidative stress levels - whether it is the ... They found that in nonsmokers, oxidative stress levels were two to four times higher after the vaping session than before. ...
Aim: To evaluate the role of oxidative stress and dyslipidemia as indicators of pathogenesis and risks of preeclampsia in ... Decreased levels of NO and TAC might reflect the oxidative stress and likely contribute to the pathophysiological mechanisms of ... Evaluating oxidative stress by measuring TAC can lead to a better understanding of free radical damage in oxidative stress ... Oxidative stress reflects an imbalance between the formation of oxidative substances and the innate antioxidants that make up ...
  • The consequence is a lower level of oxidative stress, which suggests that an appropriate diaphragmatic breathing could protect athletes from long-term adverse effects of free radicals. (hindawi.com)
  • Antioxidants can help keep free radicals in check and maintain the oxidative status in the cow. (novusint.com)
  • The terms oxidative stress and free radicals have become familiar in recent years, but I'm sure you're not the only one who doesn't fully grasp their meaning. (drweil.com)
  • The findings, which will publish on Monday in JAMA Pediatrics , show that a single 30-minute vaping session can significantly increase cellular oxidative stress, which occurs when the body has an imbalance between free radicals - molecules that can cause damage to cells - and antioxidants, which fight free radicals. (neurosciencenews.com)
  • Free radicals and reactive oxygen species (ROS) are produced more with advancement of age leads to oxidative stress. (who.int)
  • Heavy concentrations of free radicals lead to oxidative stress. (naturalnews.com)
  • While the results of the study showed that both forms of Spirulina could defend against oxidative stress, researchers found that fermented Spirulina was better equipped to scavenge free radicals and protect the body against inflammation. (bodyecology.com)
  • If free radicals exceed your body's ability to regulate them, a condition called oxidative stress occurs. (healthline.com)
  • Antioxidants are molecules that relieve oxidative stress by preventing the formation and oxidation of free radicals. (wikipedia.org)
  • Oxidative stress occurs when reactive oxygen species (ROS), also known as free radicals, outnumber antioxidants. (purebulk.com)
  • Riboflavin reduces the likelihood of oxidative damage by scavenging free radicals and boosting the levels of glutathione antioxidants. (purebulk.com)
  • Unchecked, free radicals cause oxidative stress that damages the skin, degrades its structural proteins and leads to premature aging. (eminenceorganics.com)
  • The free radicals and oxidative environment can damage DNA proteins and lipids in the skin cells. (naturalproductsinsider.com)
  • Oxidative damage to crucial biomolecules due to excess generation of reactive oxygen species has been implicated as a major cause of organ damage, and hence compounds capable of negating such damage have potential benefits. (mapi.com)
  • Persistent hyperglycaemia in diabetes mellitus increases the production of reactive oxygen species (ROS) and activates mediators of inflammation as well as suppresses antioxidant defence mechanisms ultimately contributing to oxidative stress which leads to vascular and renal injury in diabetes. (portlandpress.com)
  • Other enzymes are also involved, and NADPH oxidase, xanthine oxidase and uncoupled endothelial nitric oxide synthase are important sources of reactive oxygen species (ROS) in glucocorticoid-induced oxidative stress (see [ 9 ] for a review on this argument). (hindawi.com)
  • Reactive oxygen species (ROS) can potentially damage all endogenous cells and processes, and antioxidants help prevent this oxidative stress. (gla.ac.uk)
  • Oxidative stress, a process increased in the brain with aging, is induced by an imbalance in the redox state, involving the generation of excess reactive oxygen species (ROS) or the dysfunction of the antioxidant system ( 1 ). (spandidos-publications.com)
  • Although oxygen itself is an essential element of life, molecules in cells, such as DNA and proteins, are sometimes damaged by reactive oxygen species (ROS) in what is called oxidative stress. (dojindo.com)
  • Oxidative stress occurs when reactive oxygen species, generated mainly through aerobic respiration, overwhelm antioxidant defences and damage crucial biomolecules. (edu.au)
  • In the normal aging process, both cumulative oxidative stress and low-grade inflammation (inflammaging) play key roles. (mdpi.com)
  • Moreover, advanced age is associated with increased incidence of chronic diseases, such as cardiovascular and neurodegenerative disorders and cancer, which share oxidative stress and inflammation as pivotal players. (mdpi.com)
  • It is evident that oxidative stress and inflammation have interdependent mechanisms, and are able to induce and exacerbate each other. (mdpi.com)
  • Vascular dysfunction in autosomal dominant polycystic kidney disease is thought to be related to vascular oxidative stress and inflammation, but direct evidence is lacking. (asnjournals.org)
  • Conclusions These results provide support for the hypothesis that vascular oxidative stress and inflammation develop with autosomal dominant polycystic kidney disease. (asnjournals.org)
  • The key markers of oxidative stress and inflammation such as inflammatory cytokines (IL-1β, IL-6, and TNF-α) and immunoregulatory cytokines (IL-4 and IFN-γ) were increased in kidneys along with significant hyperglycemia. (eurekamag.com)
  • The purpose of this study is to examine whether a high-potency, black tea extract (BTE) alters the delayed onset muscle soreness (DOMS), oxidative stress, inflammation, and cortisol (CORT) responses to high-intensity anaerobic exercise. (biomedcentral.com)
  • Oxidative stress and inflammation are involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). (clinicaltrials.gov)
  • Anthocyanins from different plant foods have been shown to improve features of experimental NASH, such as oxidative stress, dyslipidemia, liver steatosis, and inflammation in rodents. (clinicaltrials.gov)
  • Quercetin complements vitamin C, inhibiting oxidative stress and inflammation to support cardiovascular health. (lifeextension.com)
  • These factors induce oxidative stress and local inflammation in the skin, which are key processes leading to skin aging. (naturalproductsinsider.com)
  • It increases local oxidative stress and inflammation, causes extensive loss and damage to collagen and elastin, and depletes the antioxidant reservoirs in the skin that serve as a defense mechanism to prevent those processes. (naturalproductsinsider.com)
  • AGEs cause inflammation and oxidative stress , which eventually lead to chronic diseases, including type 2 diabetes and cardiovascular disease. (medicalxpress.com)
  • The current review examined the role of oxidative stress in AD. (spandidos-publications.com)
  • To evaluated the role of oxidative stress on aging process in patients submitted to carotid endarterectomy. (scielo.br)
  • Aim: To evaluate the role of oxidative stress and dyslipidemia as indicators of pathogenesis and risks of preeclampsia in pregnant Sudanese women attending Wad-Medani Obstetrics and Gynecology Teaching Hospital. (scirp.org)
  • however, the role of oxidative stress in these processes needs more attention. (edu.au)
  • Using hydrogen peroxide (H2O2) as a model pro-oxidant to induce oxidative stress, we have examined the ability of the natural food supplement Maharishi Amrit Kalash (MAK-4) to decrease oxidative damage in potassium-arrested isolated rat hearts. (mapi.com)
  • In fact, there is evidence to suggest that glucocorticoids induce oxidative stress mainly by altering the expression and activity of antioxidant enzymes, thus impairing the antioxidant defense of the body [ 16 - 19 ]. (hindawi.com)
  • Building on these results, they developed the "pulse method" to artificially induce oxidative stress. (phys.org)
  • In this study, we evaluated the ability of four different NCT (NiFe2O4, CoFe2O4', Ni and Co3O4') to initiate oxidative stress, induce redox-sensitive transcription factors and trigger inflammatory response in primary human epidermal keratinocytes (HEK) and melanocytes (HEM). (cdc.gov)
  • As per various research studies, curcumin may help with the management of oxidative stress and inflammatory conditions. (selfgrowth.com)
  • Research suggests curcumin can help with the management of oxidative and inflammatory conditions, including metabolic syndrome, arthritis, anxiety, and hyperlipidemia. (thepowermall.com)
  • I also investigated the role of dietary antioxidants in reducing oxidative stress produced during exercise in adult captive budgerigars Melopsittacus undulatus. (gla.ac.uk)
  • alpha]-tocopherol, carotenoids or control, I hoped to assess the roles of different antioxidants during development in blue tits, with particular reference to plumage colouration and oxidative stress. (gla.ac.uk)
  • However, these phenomena are mainly initiated and enhanced by oxidative stress, a process referring to an imbalance between antioxidants and oxidants in favour of oxidants. (spandidos-publications.com)
  • Oxidative stress, defined as an imbalance between oxidants and antioxidants in favor of the former, plays a significant role in the pathogenesis of atherosclerotic vascular disease as well as an important determinant in the aging process 3 3. (scielo.br)
  • The 21st International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants - Paris Redox 2019 - will be organized at Pierre and Marie Curie University, Paris, France on June 20-21, 2019. (parisdescartes.fr)
  • During Paris Redox World Congress 2019, we will discuss the role of antioxidants as modulators of redox signaling pathways rather than players that counteract oxidative stress. (parisdescartes.fr)
  • The purpose of this study is to evaluate whether pterostilbene will help control cholesterol and blood pressure, as well as improve markers for oxidative stress in patients with dyslipidemia meeting inclusion criteria. (clinicaltrials.gov)
  • It is accompanied by dyslipidemia and oxidative stress leading to increase in lipid peroxidation . (bvsalud.org)
  • BACKGROUND/OBJECTIVE: The aim of this study was to examine the effect of high dietary methionine (Met) consumption on plasma and hepatic oxidative stress and dyslipidemia in chronic ethanol fed rats. (koreamed.org)
  • The idea behind the study was that the brain itself - like all tissues in our body - is subjected to constant oxidative stress, as a result of its metabolism. (eurekalert.org)
  • Our study provides novel insights on how brain metabolism relates to behavior and puts forward nutritional interventions targeting key oxidative process as ideal interventions to facilitate effortful endurance," conclude the authors. (eurekalert.org)
  • SOD is a potential therapeutic agent in diseases related to oxidative stress and as a material for moderating the aging process, because of its high antioxidant efficiency (much higher than that of glutathione or other reducing agents) and early action in the initial stages of ROS metabolism. (dojindo.com)
  • This review traces the history of Te in its biological interactions, its enigmatic toxicity, importance in cellular oxidative stress, and interaction in cysteine metabolism. (edu.pe)
  • This Special Issue, "Plant Oxidative Stress: Biology, Physiology, and Mitigation", published 11 original research works and 1 review article that discussed the various aspects of ROS Biology, metabolism, and the physiological mechanisms and approaches to mitigating oxidative stress. (doabooks.org)
  • Several mechanisms of neuronal cell death have been proposed for HD, including excitotoxicity, oxidative stress, impaired energy metabolism, and apoptosis. (medscape.com)
  • Analyzing " in vitro " the antioxidant activity of the lemon grass ( Cymbopogon citratus Stapf ) over markers of oxidative stress in erythrocytes of women on postmenopausal period. (ccsenet.org)
  • Middlekauff and her colleagues collected immune cells from each individual before and after a half-hour vaping session to measure and compare changes in oxidative stress among the groups. (neurosciencenews.com)
  • However, a more severely stressed phenotype than controls, particularly in the unfolded protein response, was evident when PE lines were switched suddenly to 20% O2, thus confirming the greater sensitivity of the PE fibroblasts to acute changes in oxidative stress. (duke.edu)
  • Me/MeO-exposed cells, both HEK and HEM, revealed a dose- and time-dependent reduction in viability, cell damage, activation of NF-kB, elevated ROS generation, release of inflammatory mediators, increase in oxidative stress and DNA damage markers. (cdc.gov)
  • The link between oxidative stress and AD is solidly supported by basic and translational research and new aspects continues to emerge in the literature. (lidsen.com)
  • As expected, H2O2 treatment following cardioplegia induced a high degree of oxidative stress as assessed by release of lactate dehydrogenase (LDH, a marker of plasma membrane damage) and total glutathione (GSH + GSSG). (mapi.com)
  • Consequently, oxidative stress on nervous tissue may seriously damage the brain via several interacting mechanisms, including an increase in intracellular free Ca 2+ , release of excitatory amino acids, and neurotoxicity ( 5 , 6 ). (spandidos-publications.com)
  • Oxidative stress has recently become the focus of many studies seeking to understand these defense mechanisms and the relationships between oxidative damage and disease or aging processes. (dojindo.com)
  • Oxidative damage to DNA results from the interaction of DNA with ROS, in particular, hydroxy radicals. (dojindo.com)
  • Measurement of these modifications is important for understanding the mechanisms of oxidative DNA damage and its biological repercussions. (dojindo.com)
  • However, clinical data clearly indicate that oxidative DNA damage is related to a number of disease processes such as carcinogenesis and neurodegenerative diseases. (dojindo.com)
  • Since glutathione also has superoxidescavenging activity, it contributes to a reductive atmosphere in cells and tissues to avoid oxidative damage. (dojindo.com)
  • and complex stress responses that include programmed cell suicide if damage is too great. (drweil.com)
  • Fluoride induced oxidative stress through depletion in levels of various anti-oxidants such as glutathione, superoxide dismutase (SOD), fat soluble vitamins (D and E) with increased levels of lipid peroxidation (LPO) and fluoride aggravate the damage in rodents as well as in humans. (fluoridealert.org)
  • O 2 -) and hydrogen peroxide (H 2 O 2 ) contribute to the oxidative stress damage and can be scavenged by superoxide dismutase (SOD) and catalase (CAT), respectively 4 4. (scielo.br)
  • Administration of a mediator of oxidative stress to FAIM-deficient animals induced more ubiquitinated protein aggregates and more organ damage as compared to wild type mice. (frontiersin.org)
  • The effects of oxidative damage include the alteration of life-history traits and reductions in whole-organism fitness. (edu.au)
  • The muscle damage and oxidative stress response following anaerobic exercise have been deemed necessary to promote skeletal muscle remodeling [ 1 , 10 - 13 ] to gain benefit from the exercise, but enhanced recovery may be advantageous for more rapidly promoting an anabolic environment. (biomedcentral.com)
  • Furthermore, we will analyze the mechanisms by which cells respond to oxidative stress and prevent cell damage and cell death. (parisdescartes.fr)
  • Among epigenetic factors, oxidative stress, which results from high free radical flux unbalanced by the antioxidant system and leads to damage of biomolecules resulting in cellular insult, is a well-known pathophysiological player in neurodegenerative disorders. (lidsen.com)
  • Collectively, these results demonstrate that diapocynin exhibits profound neuroprotective effects in a pre-clinical animal model of PD by attenuating oxidative damage and neuroinflammatory responses. (springer.com)
  • Background: The constituents of Lavandula stoechas L. possess antioxidant properties that help in protecting the mucosal cells from oxidative damage and speed up the healing process however, its role in the treatment of ethanol-induced peptic ulcers is not clear. (researchgate.net)
  • Studies also show it can also improve oxidative stress and reduce free radical damage. (thepowermall.com)
  • AGEs contribute to oxidative stress , which can damage cells (like beta cells , which produce insulin in the pancreas ). (wikipedia.org)
  • They are particularly susceptible to oxidative to ensure that women, especially adolescents, have damage from high content of unsaturated fatty acid adequate iron stores before conception ( 6 ). (who.int)
  • The best curcumin supplement for cancer will help you fight oxidative stress in your daily life. (selfgrowth.com)
  • Inhalation co-exposure to ultrafine carbon and ozone leads to significant pulmonary and systemic oxidative stress. (cdc.gov)
  • The hypothesis of this study is that consumption in binge activates AT1 receptors that will promote an increase in systemic oxidative stress. (bvsalud.org)
  • Therefore, the present project was designed to investigate the participation of AT1 receptors in systemic oxidative stress induced by the consumption of ethanol in a binge pattern. (bvsalud.org)
  • Brachial artery flow-mediated dilation was also assessed after infusion of ascorbic acid to inhibit vascular oxidative stress compared with saline. (asnjournals.org)
  • The effect of chloroquine, folic and ascorbic acid on malaria parasite induced oxidative stress was the focus of this study. (who.int)
  • Conclusion: The results suggest chloroquine and folic acid treatment to be more effective than ascorbic acid or other combination treatment employed in this study in the management of malaria induced oxidative stress. (who.int)
  • Stress is defined as a physiological reaction to undesired emotional or physical situations. (hindawi.com)
  • When stress becomes chronic and lasts for a long time, the stressed organism reacts with physiological alterations to adapt to the unfavorable conditions. (hindawi.com)
  • Is oxidative stress a physiological cost of reproduction? (liverpool.ac.uk)
  • The aims of this study were to investigate the effect of vitamin D3 administration in drinking water during lairage time prior to slaughter on physiological stress, oxidative status, and pork quality characteristics. (ucm.es)
  • Normal physiological conditions during pregnancy protect the placenta from oxidative stress, the authors explain. (contemporaryobgyn.net)
  • Information is scarce on the effects of iron supplementation on biomarkers of oxidative stress in humans. (who.int)
  • To better understand how oxidative stress levels change during puberty in girls and if such change is modified by a family history of breast cancer, we measured and compared levels of those same urinary biomarkers of oxidative stress in adolescent girls with and without a family history of breast cancer from the New York site of the Lessons in Epidemiology and Genetics of Adult Cancer from Youth cohort (LEGACY). (columbia.edu)
  • In adult women, low levels of urinary biomarkers of oxidative stress may promote cancer progression. (columbia.edu)
  • Here we review the literature addressing experimental temperature effects on oxidative stress in vertebrate ectotherms. (edu.au)
  • In experiment 2, since water intake was higher (800,000 IU and 1,120,000 IU/animal of vitamin D3 consumption) effects on oxidative status were more profound and vitamin D3 supplementation increased serum α-tocopherol and decreased cortisol and serum TBARS. (ucm.es)
  • The meeting started by in-depth lecture from Florence Barbé, researcher at Lallemand, about the causes and mechanisms of oxidative stress and its consequences at farm level. (lallemandanimalnutrition.com)
  • Consequently, RsaC may balance two interconnected defensive responses, i.e. oxidative stress and metal-dependent nutritional immunity. (ens-lyon.fr)
  • Abnormal oxidative stress responses in fibroblasts from preeclampsia infants. (duke.edu)
  • Contrary to expectations, the oxidative stress responses of these non-placental cells from PE infants were more severe than those from controls. (duke.edu)
  • Acute and acclimation temperature treatments produce distinctly different results and highlight the role of phylogeny and thermal adaptation in shaping oxidative stress responses. (edu.au)
  • Acute treatments on organisms adapted to stable environments generally produced significant oxidative stress responses, whilst organisms adapted to variable conditions exhibited capacity to cope with temperature changes and mitigate oxidative stress. (edu.au)
  • These results highlight the importance of phylogeny and adaptation to past environmental conditions for temperature-dependent oxidative stress responses. (edu.au)
  • Consumption of theaflavin-enriched black tea extract led to improved recovery and a reduction in oxidative stress and DOMS responses to acute anaerobic intervals. (biomedcentral.com)
  • Diaphragmatic breathing is relaxing and therapeutic, reduces stress, and is a fundamental procedure of Pranayama Yoga, Zen, transcendental meditation and other meditation practices. (hindawi.com)
  • Turmeric reduces oxidative stress and attenuates aortic fatty streak development in rabbits. (greenmedinfo.com)
  • Supplementation with Curcuma longa reduces oxidative stress and attenuates the development of fatty streaks in rabbits fed a high cholesterol diet. (greenmedinfo.com)
  • SodA is a Mn-dependent superoxide dismutase involved in oxidative stress response. (ens-lyon.fr)
  • Exceptionally, chloroquine and folic acid treatment did not show any significant change in oxidative stress and superoxide dismutase activity in mice when compared with control. (who.int)
  • This study evaluated the effectiveness of iron supplementation and nutrition education on improving the levels of haemoglobin and ferritin, and decreasing oxidative stress among iron-deficient female adolescents in Gaza, Palestine. (who.int)
  • The purpose of this study is to investigate whether purified anthocyanin supplementation beneficially alters oxidative, inflammatory, and apoptotic biomarkers in adults with features of NAFLD. (clinicaltrials.gov)
  • FAIM is recruited to ubiquitinated proteins induced by cellular stress and the levels of stress-induced protein aggregates are much greater in FAIM-deficient cell lines. (frontiersin.org)
  • A key element of cellular homeostasis lies in maintaining proteostasis to avoid accumulation of dysfunctional proteins due to stress-related insults. (frontiersin.org)
  • Here we report a new mammalian protein, Fas Apoptosis Inhibitory Molecule (FAIM, also termed FAIM1), that protects cells from cellular stress. (frontiersin.org)
  • Autophagy is an essential cellular mechanism of adaption to external or internal stress. (exposed-skin-care.net)
  • Since immunity and oxidative stress involve cellular mechanisms that are common to most animal species, this meeting was a great opportunity to share experiences between various species, and show that Lallemand's antioxidant and yeast derivatives solutions show robust effects across all species. (lallemandanimalnutrition.com)
  • Effects of 900-MHz electromagnetic field emitted from cellular phone on brain oxidative stress //omega.twoday .net/stories/5730284/ Dan gers of cell phone wi-fi radiation //omega.two day.net/stories/5732829/ Parents. (twoday.net)
  • Oxidative Stress Action in Cellular Aging. (bvsalud.org)
  • Thus, mitochondria function as both the source and target of toxic ROS since mitochondrial dysfunction and oxidative stress are important in aging and neurodegenerative diseases, particularly AD ( 11 , 12 ). (spandidos-publications.com)
  • Oxidative stress and mitochondrial dysfunction in Alzheimer's disease. (bvsalud.org)
  • By demonstrating distal organ oxidative stress response after pulmonary exposure, we describe a potential pathophysiologic mechanism for cardiovascular and hepatic dysfunction by air pollution exposure. (cdc.gov)
  • Li, C & Xiong, YL 2015, ' Disruption of secondary structure by oxidative stress alters the cross-linking pattern of myosin by microbial transglutaminase ', Meat Science , vol. 108, pp. 97-105. (uky.edu)
  • Initially, stress induces an acute response (fight or flight) that is mediated by catecholamines. (hindawi.com)
  • Second, iron released by hemorrhage in the endometrial cysts induces persistent oxidative stress and frequent DNA mutations. (vejthani.com)
  • Studies suggest that curcumin has potential therapeutic value against oxidative stress-induced neurodegenerative disorders. (aquanova.de)
  • Other important sources or modulators of oxidative stress, include reactive nitrogen species (RNS), including nitric oxide (NO) and peroxynitrite which can particularly be extremely reactive with proteins, lipids, nucleic acid and other molecules in further altering structure and/or functionalities leading to detrimental effects for the brain ( 7 - 9 ). (spandidos-publications.com)
  • By employing these proteins as indirect markers, oxidative stress was found to be 15% less severe in the wild-type than in the FerB-deficient mutant cells. (muni.cz)
  • Oxidative stress altered the levels of proteins whose expression is dependent on the transcriptional factor FnrP. (muni.cz)
  • While the level of FerB remained relatively constant, two proteins homologous to FerB accumulated during oxidative stress. (muni.cz)
  • Adolescents of today are the Oxidative stress is defined as an imbalance between adult population of tomorrow and therefore their health the oxidation and anti-oxidation systems, resulting in and wellbeing are important ( 5 ). (who.int)
  • Peroxiredoxin1 (PRX-1) is an antioxidant protein that functions to regulate oxidative stress in aerobic organisms by reducing hydrogen peroxide. (suny.edu)
  • Protein oxidation in aging, disease, and oxidative stress. (scielo.br)
  • These results identify a completely new actor that protects cells against stress-induced loss of viability by preventing protein aggregation. (frontiersin.org)
  • The observed down-regulation of the fnrP regulon members, most notably that of nitrous oxide reductase, was tentatively explained by an oxidative degradation of the [4Fe-4S] center of FnrP leading to a protein form which no longer activates transcription. (muni.cz)
  • Porcine myofibrillar protein (MP) was oxidatively stressed in an iron-H 2 O 2 radical-producing system then subjected to microbial transglutaminase (TGase, E:S=1:20) at 4°C. Changes in the MP secondary structure and cross-linking site on myosin (subfragments S1, S2, rod, light meromyosin, and heavy meromyosin) after TGase treatment were investigated. (uky.edu)
  • BACKGROUND: Signs of severe oxidative stress are evident in term placentae of infants born to mothers with preeclampsia (PE), but it is unclear whether this is a cause or consequence of the disease. (duke.edu)
  • Accumulating evidence suggests that oxidative stress influences the onset of preeclampsia, but the mechanism is unclear. (contemporaryobgyn.net)
  • In this study, the authors measured the post-mortem cerebellar concentrations of a marker for oxidative stress, 3-nitrotyrosine (3-NT), in ten normal brains and in nine brains of autistic children. (eeginfo.com)
  • The serum oxidative stress marker levels of the groups were given in Table 2 . (medscape.com)
  • There was no significant difference between the low-risk and moderate-risk PE groups concerning the oxidative marker levels. (medscape.com)
  • Comparison of placental biopsies from 18 preeclamptic pregnancies and 23 normotensive controls revealed that placental levels of the oxidative stress marker 8-hydroxy-2'-deoxy-guanosine (8-OHdG) were markedly higher in preeclamptic than normotensive patients and that an inverse correlation existed between IDO and 8-OHdG levels. (contemporaryobgyn.net)
  • CONCLUSIONS: UC fibroblasts derived from PE infants are intrinsically less able to respond to acute oxidative stress than controls, and this phenotype is retained over many cell doublings. (duke.edu)
  • therefore, in this study, we investigated the effects of diaphragmatic breathing on exercise-induced oxidative stress and the putative role of cortisol and melatonin hormones in this stress pathway. (hindawi.com)
  • FerB is a cytoplasmic flavoprotein from the soil bacterium Paracoccus denitrificans with a putative role in defense against oxidative stress. (muni.cz)
  • Considering that nocturia has been reported to be associated with several health-related disorders , our observation supports the negative effect of deteriorated general health status via oxidative stress on nocturia," Dr Hatakeyama and colleagues stated. (renalandurologynews.com)
  • Intro Oxidative stress causes harm to multiple mobile substances and is a significant contributing element in a number of individual diseases such as for example cancer tumor neurodegenerative disorders inflammatory illnesses coronary disease and ageing [1]. (exposed-skin-care.net)
  • In response, aerobic organisms created defense mechanisms to avoid oxidative stress. (dojindo.com)
  • As Guest Editor for this Special Issue of the journal OBM Geriatrics, it is my pleasure to invite you to submit a feature article, which may be either a review or a research paper, on the topic of Oxidative Stress and Alzheimer's Disease. (lidsen.com)
  • Based on this study, certain antioxidant enzymes involved in oxidative stress defense could be useful targets for further examination. (news-medical.net)
  • Simultaneously, oxidative stress (OS) is a critical factor in the aging process, resulting from an imbalance between reactive oxygen and nitrogen species and the antioxidant defense system. (bvsalud.org)
  • Of course, cells have a number of mechanisms in place to clear oxidative species out, restoring the cell's chemical balance. (eurekalert.org)
  • We investigated whether RWE (red wine extract) prevents oxidative-stress-induced senescence in HUVECs (human umbilical-vein endothelial cells). (nih.gov)
  • Cells are suffering from a defence program a number of antioxidant substances and enzymes to detoxify oxidative types. (exposed-skin-care.net)
  • The metabolic response of Arabidopsis roots to oxidative stress is distinct from that of heterotrophic cells in culture and highlights a complex relationship between the levels of transcripts, metabolites, and flux. (ox.ac.uk)
  • 2007), the metabolic response of Arabidopsis cells in culture to induction of oxidative stress by menadione was characterized. (ox.ac.uk)
  • In addition, interactions of nanoparticles (NPs) with constituent skin cell types, in particular after the cells have been subjected to environmental stress like UVB exposure (considered as the main cause of skin cancer) are essential. (cdc.gov)
  • Red blood cells are has changed recently, from providing nutritional subjected to continuous oxidative stress during their supplements during pregnancy to taking steps earlier lifetime. (who.int)
  • The longevity regulator Sirt1 is a NAD ⁺ -dependent deacetylase that has a potential antioxidative stress activity in vascular ECs. (researchgate.net)
  • Constitutively turned on NRF2 promotes longevity and confers elevated tolerance to oxidative tension in model microorganisms [6] [7]. (exposed-skin-care.net)
  • Minerals are key components of antioxidant enzymes and MINTREX limits exposure to oxidation, keeping a cow's system in better oxidative balance. (novusint.com)
  • The SC COBRE in Oxidants, Redox Balance and Stress Signaling is seeking applications for Pilot Discovery Grants in the areas of oxidative stress and redox signaling. (musc.edu)
  • The application is open to any area of research that places an emphasis on how redox and oxidative stress affect human disease. (musc.edu)
  • Investigators with previous redox and oxidative research experience and those investigators new to these areas of research are both encouraged to apply. (musc.edu)
  • We will also highlight oxidative stress evaluation and discuss the recent advances on biomarkers, related to redox alteration. (parisdescartes.fr)
  • To understand mechanisms of redox control and their role in oxidative stress pathologies and aging, it is necessary to identify and dissect the function of the key players of redox processes. (parisdescartes.fr)
  • A team of researchers under the direction of Dr. Jeffrey Teckman in the Department of Pediatrics at St. Louis University, have demonstrated that oxidative stress occurs in a genetic model of alpha-1-antitrypsin deficiency. (news-medical.net)
  • Steven R. Goodman, PhD, Editor-in-Chief of Experimental Biology and Medicine said, 'Teckman and colleagues have demonstrated that oxidative stress occurs in an animal model of Alpha-1-antitrypsin deficiency. (news-medical.net)
  • Chronic renal and vascular oxidative stress in association with an enhanced inflammatory burden are determinant processes in the development and progression of diabetic complications including cardiovascular disease (CVD), atherosclerosis and diabetic kidney disease (DKD). (portlandpress.com)
  • potential antioxidative stress activity in vascular ECs. (researchgate.net)
  • However, addition of MAK-4 in the perfusate containing H2O2 decreased oxidative stress in terms of release of LDH and glutathione. (mapi.com)
  • Spirulina may safeguard against toxicity, stress, and degeneration in the brain. (bodyecology.com)
  • Researchers at the Defence Institute of Physiology and Allied Sciences in Delhi, India, found that Spirulina may safeguard against toxicity, stress, and degeneration in the brain. (bodyecology.com)
  • However, circulating oxidative stress markers and bioactive lipid mediators did not significantly differ according to the autosomal dominant polycystic kidney disease diagnosis. (asnjournals.org)
  • This study demonstrated an increased occurrence of atherogenic lipid profile and oxidative stress among hypertensive patients . (bvsalud.org)
  • This system, common to photosynthetic organisms , starts to function when excess light energy is present (caused by environmental stresses such as strong sunlight, drought, or lack of nutrients). (phys.org)
  • Our hypothesis is that AHL defect results in increased sensitivity to oxidative stress and L-NAC would be able to protect the hearing of a mouse model of pre-mature AHL, the C57BL/6J (B6) mouse strain. (cdc.gov)
  • In an observational study, Shingo Hatakeyama, MD, of Hirosaki University Graduate School of Medicine in Japan, and collaborators examined several indicators of oxidative stress and their relationship with lower urinary tracts symptoms (LUTS) in 1113 men and women in the Iwaki Health Promotion Project of 2015. (renalandurologynews.com)
  • The relationship between oxidative stress and lower urinary tract symptoms: Results from the community health survey in Japan. (renalandurologynews.com)
  • Methods: To determine the relationship between oxidative stress and breast cancer risk in adult women with a family history of breast cancer we measured and compared urinary levels of 8-OxodG and F2-Isoprostane in a prospective matched case control study nested within the New York Breast Cancer Family Registry. (columbia.edu)

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