Amino-substituted glyoxylic acid derivative.

Roles of the Dal82p domains in allophanate/oxalurate-dependent gene expression in Saccharomyces cerevisiae. (1/52)

Allophanate/oxalurate-induced gene expression in Saccharomyces cerevisiae requires at least five transcription factors, four of which act positively (Gln3p, Gat1p, Dal81p, and Dal82p) and one negatively (Dal80p). Gln3p binds to and Gat1p is proposed to bind to single GATA sequences; Dal80p binds to pairs of specifically oriented and spaced GATA sequences, and Dal82p binds to a pathway-specific element, UIS(ALL). Dal82p consists of at least three domains as follows: (i) UIS(ALL) DNA-binding, (ii) transcriptional activation, and (iii) coiled-coil(DAL82). Here we show that the coiled-coil(DAL82) domain possesses two demonstrable functions. (i) It prevents Dal82p-mediated transcription when inducer is absent. (ii) It is a major, although not exclusive, domain through which the inducer signal is received. Supporting the latter conclusion, a 38-amino acid fragment, containing little more than the coiled-coil(DAL82) domain, supports oxalurate-inducible, Dal81p-dependent, reporter gene transcription. Dal81p is required for inducer responsiveness of LexAp-Dal82p and LexAp coiled-coil(DAL82)-mediated transcription but isn't needed for inducer-dependent activation mediated by a Dal82p containing deletions in both the coiled-coil(DAL82), UIS(ALL)-binding domains. There may be an interaction between Dal81p and the coiled-coil(DAL82) domain since (i) Dal81p is required for transcription mediated by LexA-coiled-coil(DAL82)p and (ii) a Dal81p-Dal82p complex is detected by two-hybrid assay.  (+info)

The precursor strategy: terminus methoxyoxalamido modifiers for single and multiple functionalization of oligodeoxyribonucleotides. (2/52)

Synthesis of new terminus modifiers, bearing, along with a phosphoramidite moiety, one, two or four methoxyoxalamido (MOX) precursor groups, is described. These modifiers are introduced onto the 5'-end of a synthetic oligodeoxyribonucleotide as the last step of an automated synthesis to form the MOX precursor oligonucleotide. The MOX groups are then post-synthetically derivatized with an appropriate primary amine to construct a 5'-modified oligonucleotide. The efficiency and simplicity of the novel modifying strategy were demonstrated in the synthesis of a number of 5'-functionalized oligonucleotides.  (+info)

Relationships between inhibition constants, inhibitor concentrations for 50% inhibition and types of inhibition: new ways of analysing data. (3/52)

The concentration of an inhibitor that decreases the rate of an enzyme-catalysed reaction by 50%, symbolized i(0.5), is often used in pharmacological studies to characterize inhibitors. It can be estimated from the common inhibition plots used in biochemistry by means of the fact that the extrapolated inhibitor concentration at which the rate becomes infinite is equal to -i(0.5). This method is, in principle, more accurate than comparing the rates at various different inhibitor concentrations, and inferring the value of i(0.5) by interpolation. Its reciprocal, 1/i(0.5), is linearly dependent on v(0)/V, the uninhibited rate divided by the limiting rate, and the extrapolated value of v(0)/V at which 1/i(0.5) is zero allows the type of inhibition to be characterized: this value is 1 if the inhibition is strictly competitive; greater than 1 if the inhibition is mixed with a predominantly competitive component; infinite (i.e. 1/i(0.5) does not vary with v(0)/V) if the inhibition is pure non-competitive (i.e. mixed with competitive and uncompetitive components equal); negative if the inhibition is mixed with a predominantly uncompetitive component; and zero if it is strictly uncompetitive. The type of analysis proposed has been tested experimentally by examining inhibition of lactate dehydrogenase by oxalate (an uncompetitive inhibitor with respect to pyruvate) and oxamate (a competitive inhibitor with respect to pyruvate), and of cytosolic malate dehydrogenase by hydroxymalonate (a mixed inhibitor with respect to oxaloacetate). In all cases there is excellent agreement between theory and experiment.  (+info)

X-ray structure of pyruvate formate-lyase in complex with pyruvate and CoA. How the enzyme uses the Cys-418 thiyl radical for pyruvate cleavage. (4/52)

The glycyl radical enzyme pyruvate formate-lyase (PFL) synthesizes acetyl-CoA and formate from pyruvate and CoA. With the crystal structure of the non-radical form of PFL in complex with its two substrates, we have trapped the moment prior to pyruvate cleavage. The structure reveals how the active site aligns the scissile bond of pyruvate for radical attack, prevents non-radical side reactions of the pyruvate, and confines radical migration. The structure shows CoA in a syn conformation awaiting pyruvate cleavage. By changing to an anti conformation, without affecting the adenine binding mode of CoA, the thiol of CoA could pick up the acetyl group resulting from pyruvate cleavage.  (+info)

An alpha-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum. Cloning and biochemical characterization of the enzyme. (5/52)

Malate dehydrogenase (MDH) may be important in carbohydrate and energy metabolism in malarial parasites. The cDNA corresponding to the MDH gene, identified on chromosome 6 of the Plasmodium falciparum genome, was amplified by RT-PCR, cloned and overexpressed in Escherichia coli. The recombinant Pf MDH was purified to homogeneity and biochemically characterized as an NAD(+)(H)-specific MDH, which catalysed reversible interconversion of malate to oxaloacetate. Pf MDH could not use NADP/NADPH as a cofactor, but used acetylpyridine adenine dinucleoide, an analogue of NAD. The enzyme exhibited strict substrate and cofactor specificity. The highest levels of Pf MDH transcripts were detected in trophozoites while the Pf MDH protein level remained high in trophozoites as well as schizonts. A highly refined model of Pf MDH revealed distinct structural characteristics of substrate and cofactor binding sites and important amino acid residues lining these pockets. The active site amino acid residues involved in substrate binding were conserved in Pf MDH but the N-terminal glycine motif, which is involved in nucleotide binding, was similar to the GXGXXG signature sequence found in Pf LDH and also in alpha-proteobacterial MDHs. Oxamic acid did not inhibit Pf MDH, while gossypol, which interacts at the nucleotide binding site of oxidoreductases and shows antimalarial activity, inhibited Pf MDH also. Treatment of a synchronized culture of P. falciparum trophozoites with gossypol caused induction in expression of Pf MDH, while expression of Pf LDH was reduced and expression of malate:quinone oxidoreductase remained unchanged. Pf MDH may complement Pf LDH function of NAD/NADH coupling in malaria parasites. Thus, dual inhibitors of Pf MDH and Pf LDH may be required to target this pathway and to develop potential new antimalarial drugs.  (+info)

Trypanosoma cruzi: inhibition of alpha-hydroxyacid dehydrogenase isozyme II by N-allyl and N-propyl oxamates and their effects on intact epimastigotes. (6/52)

N-allyl (NAOx) and N-propyl (NPOx) oxamates were designed as inhibitors of alpha-hydroxyacid dehydrogenase (HADH) isozyme II from Trypanosoma cruzi. The kinetic studies showed that NAOx and NPOx were competitive inhibitors of HADH-isozyme II (Ki = 72 microM, IC50 = 0.33 mM and 70 microM, IC50 = 0.32 mM, respectively). The attachment of the allylic and propylic chains to nitrogen of the competitive inhibitor oxamate (Ki = 0.91 mM, IC50 = 4.25 mM), increased 12.6 and 13-folds respectively, the affinity for T. cruzi HADH-isozyme II. NAOx and NPOx were selective inhibitors of HADH-isozyme II, because other T. cruzi dehydrogenases were not inhibited by these substances. Since HADH-isozyme II participates in the energy metabolism of T. cruzi, a trypanocidal effect can be expected with these inhibitors. However, we were not able to detect any trypanocidal activity with these oxamates. When the corresponding ethyl esters of N-allyl (Et-NAOx) and N-propyl (Et-NPOx) oxamates were tested as a possible trypanocidal prodrugs, in comparison with nifurtimox and benznidazole, the expected trypanocidal effects were obtained.  (+info)

Identification of N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4. (7/52)

We have identified two N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide analogs as a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors that block the gp120-CD4 interaction, using database screening techniques. The lead compounds, NBD-556 and NBD-557, are small molecule organic compounds with drug-like properties. These compounds showed potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels. A systematic study showed that these compounds target viral entry by inhibiting the binding of HIV-1 envelope glycoprotein gp120 to the cellular receptor CD4 but did not inhibit reverse transcriptase, integrase, or protease, indicating that they do not target the later stages of the HIV-1 life cycle to inhibit HIV-1 infection. These compounds were equally potent inhibitors of both X4 and R5 viruses tested in CXCR4 and CCR5 expressing cell lines, respectively, indicating that their anti-HIV-1 activity is not dependent on the coreceptor tropism of the virus. A surface plasmon resonance study, which measures binding affinity, clearly demonstrated that these compounds bind to unliganded HIV-1 gp120 but not to the cellular receptor CD4. NBD-556 and NBD-557 were active against HIV-1 laboratory-adapted strains including an AZT-resistant strain and HIV-1 primary isolates, indicating that these compounds can potentially be further modified to become potent HIV-1 entry inhibitors.  (+info)

Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells. (8/52)

The anticancer drug cisplatin is nephrotoxic and neurotoxic. Previous data support the hypothesis that cisplatin is bioactivated to a nephrotoxicant. The final step in the proposed bioactivation is the formation of a platinum-cysteine S-conjugate followed by a pyridoxal 5'-phosphate (PLP)-dependent cysteine S-conjugate beta-lyase reaction. This reaction would generate pyruvate, ammonium, and a highly reactive platinum (Pt)-thiol compound in vivo that would bind to proteins. In this work, the cellular location and identity of the PLP-dependent cysteine S-conjugate beta-lyase were investigated. Pt was shown to bind to proteins in kidneys of cisplatin-treated mice. The concentration of Pt-bound proteins was higher in the mitochondrial fraction than in the cytosolic fraction. Treatment of the mice with aminooxyacetic acid (AOAA, a PLP enzyme inhibitor), which had previously been shown to block the nephrotoxicity of cisplatin, decreased the binding of Pt to mitochondrial proteins but had no effect on the amount of Pt bound to proteins in the cytosolic fraction. These data indicate that a mitochondrial enzyme catalyzes the PLP-dependent cysteine S-conjugate beta-lyase reaction. PLP-dependent mitochondrial aspartate aminotransferase (mitAspAT) is a mitochondrial enzyme that catalyzes beta-elimination reactions with cysteine S-conjugates of halogenated alkenes. We reasoned that the enzyme might also catalyze a beta-lyase reaction with the cisplatin-cysteine S-conjugate. In this study, mitAspAT was stably overexpressed in LLC-PK(1) cells. Cisplatin was significantly more toxic in confluent monolayers of LLC-PK(1) cells that overexpressed mitAspAT than in control cells containing vector alone. AOAA completely blocked the cisplatin toxicity in confluent mitAspAT-transfected cells. The Pt-thiol compound could rapidly bind proteins and inactivate enzymes in close proximity of the PLP-dependent cysteine S-conjugate beta-lyase. Treatment with 50 or 100 microM cisplatin for 3 h, followed by removal of cisplatin from the medium for 24 h, resulted in a pronounced loss of alpha-ketoglutarate dehydrogenase complex (KGDHC) activity in both mitAspAT-transfected cells and control cells. Exposure to 100 microM cisplatin resulted in a significantly greater loss of KGDHC activity in the cells overexpressing mitAspAT than in control cells. Aconitase activity was diminished in both cell types, but only at the higher level of exposure to cisplatin. AspAT activity was also significantly decreased by cisplatin treatment. By contrast, several other enzymes (both cytosolic and mitochondrial) involved in energy/amino acid metabolism were not significantly affected by cisplatin treatment in the LLC-PK(1) cells, whether or not mitAspAT was overexpressed. The susceptibility of KGDHC and aconitase to inactivation in kidney cells exposed to cisplatin metabolites may be due to the proximity of mitAspAT to KGDHC and aconitase in mitochondria. These findings support the hypothesis that a mitochondrial cysteine S-conjugate beta-lyase converts the cisplatin-cysteine S-conjugate to a toxicant, and the data are consistent with the hypothesis that mitAspAT plays a role in the bioactivation of cisplatin.  (+info)

I'm sorry for any confusion, but "Oxamic Acid" is not a recognized term in medical terminology or pharmacology. It might be a chemical compound that you're interested in, and its scientific definition is as follows:

Oxamic acid, systematically named as ethanedioloic acid or oxalic acid diethyl ester, is an organic compound with the formula (CH3CH2)2C(COOH)2. It is a colorless liquid that is used as a solvent and in the manufacture of other chemicals.

If you're looking for medical information or definitions related to a different term, please let me know and I would be happy to help!

... inhibits lactate dehydrogenase A. The active site of lactate dehydrogenase (LDH) is closed off once oxamic acid ... Oxamic acid is an organic compound with the formula NH2C(O)COOH. It is a white, water-soluble solid. It is the monoamide of ... Oxamic acid also has applications in polymer chemistry. It increases the water solubility of certain polymers, including ... Oxamate, the conjugate base of oxamic acid Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 ( ...
... is the carboxylate anion of oxamic acid. Oxamate has a molecular formula of C2H2NO3− and is an isosteric form of ... Salts and esters of oxamic acid are known collectively as oxamates. Oxamate is a competitive inhibitor of the enzyme lactate ... Oxamate also plays inhibiting roles with oxaloacetate, an important intermediate for the citric acid cycle. Oxamate competes ...
They discovered that N-substituted oxamic acids had enzyme inhibitory properties. Then it was found that the synthetic compound ... N-acetylneuraminic acid (Neu5Ac) is one of the two most common sialic acid in mammals. It is a monosaccharide with a backbone ... Including a glutamic acid residue binding the C7 and C9 alcohol groups on the glycerol side-chain (at C6) with hydrogen bonds ... The three arginine residues that bind the C1 acid-group with salt bridges in vNEU are also present in hNEU. Active site ...
Reacting sodium oxamate (the sodium salt of oxamic acid) with hydrochloric acid yields some tetraketopiperazine. A higher yield ... Glyoxalic acid and oxamide are side products. When heated tetraketopiperazine does not melt, but turns black at 250°C. ... Tetraketopiperazine is slightly soluble in water and more so in boiling acetic acid. The solid form has monoclinic prismatic ...
In 1886 Ost and Mente claimed to produce oximide by the reaction of oxamic acid with phosphorus pentachloride (PCl5). However, ... Oximide is an unstable chemical compound, the cyclic imide of oxalic acid. Other names for this are the systematic name 2,3- ...
In organic chemistry he published papers on the decomposition of ammonium oxalate, with formation of oxamic acid, on amyl ... crystals while he was working with tartaric acid.[citation needed] Balard died in Paris on 30 April 1876. While the discovery ...
... oxamic acid MeSH D02.241.152.811 - uronic acids MeSH D02.241.152.811.325 - glucuronic acids MeSH D02.241.152.811.325.300 - ... quinic acid MeSH D02.241.511.852 - shikimic acid MeSH D02.241.511.902 - sugar acids MeSH D02.241.511.902.107 - ascorbic acid ... edetic acid MeSH D02.241.081.038.455 - egtazic acid MeSH D02.241.081.038.581 - iodoacetic acid MeSH D02.241.081.038.581.400 - ... hexuronic acids MeSH D02.241.081.844.915.400.500 - iduronic acid MeSH D02.241.081.901.177 - aconitic acid MeSH D02.241.081.901. ...
Oxamic acid inhibits lactate dehydrogenase A. The active site of lactate dehydrogenase (LDH) is closed off once oxamic acid ... Oxamic acid is an organic compound with the formula NH2C(O)COOH. It is a white, water-soluble solid. It is the monoamide of ... Oxamic acid also has applications in polymer chemistry. It increases the water solubility of certain polymers, including ... Oxamate, the conjugate base of oxamic acid Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 ( ...
"Oxamic Acid" by people in this website by year, and whether "Oxamic Acid" was a major or minor topic of these publications. ... "Oxamic Acid" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Oxamic Acid" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Oxamic Acid". ...
... we determined that the addition of δ-aminolevulinic acid (5-ALA) to a panel of glioblastoma multiforme (GBM) cells caused a ... Louis, MO, USA; REF#A3785), Tartronic acid (TART, Sigma-Aldrich; St. Louis, MO, USA; REF#86320), Oxamic acid (OXM, Sigma- ... oxamic acid, or tarronic acid (1000 μM). Error bars represent one SD; Figure S2: Increase in OCR, following the addition of LDH ... oxamic acid, tartronic acid. Error bars represent one SD; Figure S3: Decrease in glycolytic activity of GBM cell lines upon ...
Comprehensive supplier list for Acetic acid, [[(2-bromophenyl)methyl]thio]-,Acetic acid, [[(2-chloro-1-propenyl)oxy]imino]- ... Synonyms: n-(3-nitrobenzyl)-oxamic acid, SCHEMBL7462472, AKOS011793248 Molecular Formula: C9H8N2O5. Molecular Weight: 224.172 [ ... Acetic acid, [[(2-chloro-1-propenyl)oxy]imino]- (1 supplier). IUPAC Name: 2-(2-chloroprop-1-enoxyimino)acetic acid , CAS ... Acetic acid, [[(3-chloro-1-propenyl)oxy]imino]- (1 supplier). IUPAC Name: 2-(3-chloroprop-1-enoxyimino)acetic acid , CAS ...
Nunez, L.; Barral, L.; Pilcher, G., Enthalpies of combustion of oxamic acid, oxamide, and dithiooxamide, J. Chem. Thermodyn., ... Nunez, L.; Barral, L.; Pilcher, G., Enthalpies of combustions of oxamic acid, oxamide, and dithiooxamide, J. Chem. Thermodyn., ... 2-aminoethanesulfonic acid, and the three aminobenzenesulfonic acids, J. Chem. Thermodyn., 1994, 26, 787-790. [all data] ... 2-aminoethanesulfonic acid, and the three aminobenzenesulfonic acids, J. Chem. Thermodyn., 1994, 26, 787-90. [all data] ...
The electro-reduction of dicyanogen and oxamic acid. 1936, Vol. 8, pp. 114-124 [Abstract] ...
Oxamic acid. 15. A. 328. 256. -72. 1.280. C2H3NO3. Oxamic acid. 21. A". 162. 114. -48. 1.422. ... Oxamic acid. 3. A. 2600. 3343. 743. 0.778. C2H3NO3. ... Sulfuric acid. 8. A. 224. 154. -70. 1.450. H2SO4. Sulfuric acid ...
3-[18-(2-Carboxyethyl)-7,12-bis(ethenyl)-3,8,13,17-tetramethyl-21,23-dihydroporphyrin-2-yl]propanoic acid ... 2-Amino-6-[(3,4,5,6-tetrahydroxy-2-oxohexyl)amino]hexanoic acid (non-preferred name) ... hydroxy([(6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy)phosphoryl]oxyphosphonic acid ... 2-[[9-[3,4-Dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]amino]butanedioic acid ...
Oxamic Acid 44% * 7,7-dimethoxy-(4,4-bi-1,3-benzodioxole)-5,5-dicarboxylic acid dimethyl ester 39% ... Dive into the research topics of Comparative electrochemical degradation of salicylic and aminosalicylic acids: Influence of ... Comparative electrochemical degradation of salicylic and aminosalicylic acids: Influence of functional groups on decay kinetics ...
oxamic-acid. *monosodium glutamate. *mono1. Advertisement Find Similar Words Find similar words to monovalent using the buttons ...
Oxalamic Acid use Oxamic Acid Oxalates Oxalic Acid Oxalicum Acidum Oxalis acetosella ... Omega-3 Fatty Acids use Fatty Acids, Omega-3 Omega-6 Fatty Acids use Fatty Acids, Omega-6 ...
Oxalamic Acid use Oxamic Acid Oxalates Oxalic Acid Oxalicum Acidum Oxalis acetosella ... Omega-3 Fatty Acids use Fatty Acids, Omega-3 Omega-6 Fatty Acids use Fatty Acids, Omega-6 ...
Oxalamic Acid use Oxamic Acid Oxalates Oxalic Acid Oxalicum Acidum Oxalis acetosella ... Omega-3 Fatty Acids use Fatty Acids, Omega-3 Omega-6 Fatty Acids use Fatty Acids, Omega-6 ...
Oxalamic Acid use Oxamic Acid Oxalates Oxalic Acid Oxalicum Acidum Oxalis acetosella ... Omega-3 Fatty Acids use Fatty Acids, Omega-3 Omega-6 Fatty Acids use Fatty Acids, Omega-6 ...
Oxalamic Acid use Oxamic Acid Oxalates Oxalic Acid Oxalicum Acidum Oxalis acetosella ... Omega-3 Fatty Acids use Fatty Acids, Omega-3 Omega-6 Fatty Acids use Fatty Acids, Omega-6 ...
Oxalamic Acid use Oxamic Acid Oxalates Oxalic Acid Oxalicum Acidum Oxalis acetosella ... Omega-3 Fatty Acids use Fatty Acids, Omega-3 Omega-6 Fatty Acids use Fatty Acids, Omega-6 ...
Oxalamic Acid use Oxamic Acid Oxalates Oxalic Acid Oxalicum Acidum Oxalis acetosella ... Omega-3 Fatty Acids use Fatty Acids, Omega-3 Omega-6 Fatty Acids use Fatty Acids, Omega-6 ...
Oxalamic Acid use Oxamic Acid Oxalates Oxalic Acid Oxalicum Acidum Oxalis acetosella ... Omega-3 Fatty Acids use Fatty Acids, Omega-3 Omega-6 Fatty Acids use Fatty Acids, Omega-6 ...
... oxamic acid, oxamide, hydrocyanic acid, formic acid, and Prussian blue; whilst among organic bases we have cyanic acid. Nor is ... acid) to 185° to 190° for such a length of time, till it forms, And that of nitro-benzene on a mixture of aniline and after ... arsenious and arsenic acid in the melt with caustic soda, driving off the un-converted aniline by a current of steam, ... hydrochloric acid. After it is dissolved water is added slowly under agitation to five times the weight of glycerin, by which ...
Glutamic acid is the most common excitatory neurotransmitter in the brain. Aspartic acid has been regarded as an excitatory ... "Excitatory Amino Acids" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Effect of propofol on spinal excitatory amino acid accumulation]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Jun; 23(6):723 ... This graph shows the total number of publications written about "Excitatory Amino Acids" by people in Harvard Catalyst Profiles ...
Our paper on Visible-light Photocatalyzed Oxidative Decarboxylation of Oxamic Acids. A Green Route to Urethanes and Ureas has ... Our paper on Visible-light Photocatalyzed Oxidative Decarboxylation of Oxamic Acids. A Green Route to Urethanes and Ureas has ...
The use of ascorbic acid for the mild, metal-free reduction of in situ formed diazonium salts is presented. The oxamic acid ... Publication 18: Continuous Production of Oxamic Acid Derivatives in the Mild, Metal-free reduction of Diazonium Salts to ... A new flow-through, multi-step synthesis of the achiral unnatural amino acid 2-amino-2-adamantane-2-carboxylic acid has ... Boronic acids are versatile intermediates in synthesis that are typically used to form C-C, C-O and C-N bonds under metal ...
Silver-promoted decarboxylative radical addition/annulation of oxamic acids with gem-difluoroolefins: concise access to CF2- ... Described is a silver-promoted decarboxylative radical addition/annulation of oxamic acids with gem-difluoroalkenes. This ...
Oxalamic Acid use Oxamic Acid Oxalates Oxalic Acid Oxalic Acids Oxalicum Acidum ... Omega-3 Fatty Acids use Fatty Acids, Omega-3 Omega-6 Fatty Acids use Fatty Acids, Omega-6 ...
Oxalamic Acid use Oxamic Acid Oxalates Oxalic Acid Oxalic Acids Oxalicum Acidum ... Omega-3 Fatty Acids use Fatty Acids, Omega-3 Omega-6 Fatty Acids use Fatty Acids, Omega-6 ...
Oxalamic Acid use Oxamic Acid Oxalates Oxalic Acid Oxalic Acids Oxalicum Acidum ... Omega-3 Fatty Acids use Fatty Acids, Omega-3 Omega-6 Fatty Acids use Fatty Acids, Omega-6 ...
Oxalamic Acid use Oxamic Acid Oxalates Oxalic Acid Oxalic Acids Oxalicum Acidum ... Omega-3 Fatty Acids use Fatty Acids, Omega-3 Omega-6 Fatty Acids use Fatty Acids, Omega-6 ...
2.Pd(II)-catalyzed decarboxylative cross-coupling of oxamic acids with potassium phenyltrifluoroborates under mild conditions ... 1.Catalytic-allylation of unprotected amino acid esters Ping Fang, Mani Raj Chaulagain, Zachary D. Aron* Org. Lett. 2012, 14, ... 3.Room temperature palladium-catalyzed decarboxylative ortho-acylation of acetanilides with-oxocarboxylic acids Ping Fang, ...
Tenuazonic Acid. Japan Wax. Nequinate. Oxamic Acid. Ixbut. Mefenorex. Silver(II) Oxide. Gaboxadol. ...
In organic chemistry he published papers on the decomposition of ammonium oxalate, with formation of oxamic acid, on amyl ... crystals while he was working with tartaric acid.[citation needed] Balard died in Paris on 30 April 1876. ...
  • Excitatory Amino Acids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Endogenous amino acids released by neurons as excitatory neurotransmitters. (harvard.edu)
  • This graph shows the total number of publications written about "Excitatory Amino Acids" by people in Harvard Catalyst Profiles by year, and whether "Excitatory Amino Acids" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Excitatory Amino Acids" by people in Profiles. (harvard.edu)
  • A role for excitatory amino acids in diabetic eye disease. (harvard.edu)
  • Amino acids which have a branched carbon chain. (wakehealth.edu)
  • Because the property of tin ore is more and more complex, the oleic acids should be combined with other fatty acids collectors to complete the process. (xinhaimining.com)
  • Compared with fatty acids and arsenic acids, its toxicity is small but capture capacity is weak. (xinhaimining.com)
  • Alkylsulfosuccinic acids is similar to fatty acids. (xinhaimining.com)
  • Described is a silver-promoted decarboxylative radical addition/annulation of oxamic acids with gem-difluoroalkenes. (bvsalud.org)
  • 2.Pd(II)-catalyzed decarboxylative cross-coupling of oxamic acids with potassium phenyltrifluoroborates under mild conditions Mingzong Li, Cong Wang, Ping Fang, Haibo Ge* Chem. (cas.cn)
  • 3.Room temperature palladium-catalyzed decarboxylative ortho-acylation of acetanilides with-oxocarboxylic acids Ping Fang, Mingzong Li, Haibo Ge* J. Am. Chem. (cas.cn)
  • A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo. (harvard.edu)
  • Effect of propofol on spinal excitatory amino acid accumulation]. (harvard.edu)
  • An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. (nih.gov)
  • Oxamic acid inhibits lactate dehydrogenase A. The active site of lactate dehydrogenase (LDH) is closed off once oxamic acid attaches to the LDH-NADH complex, effectively inhibiting it. (wikipedia.org)
  • This base is converted with aniline and acetic acid into the spirit-soluble indulin or its base (as described above), which is made soluble with oil of vitriol, similarly as the indulin base from magenta refuse. (google.pl)
  • It was in Balard's laboratory that Pasteur discovered the difference between "right-handed" and "left-handed" crystals while he was working with tartaric acid. (detailedpedia.com)
  • If there is no hydrochloride of aniline, or of the mixture of aniline and toluydin, and no free aniline or toluydin to be acted upon, then the process must be watched very carefully, and by all means be kept below 190°, else a large quantity of by-products is formed, much easier than in the same process without hydrochloric acid. (google.pl)
  • hydrochloric acid. (google.pl)
  • When processing tin ore by flotation separation technology, the common used activators are sulphuric acid, copper sulfate, sodium sulfate, hydrochloric acid, and soda. (xinhaimining.com)
  • arsenious and arsenic acid in the melt with caustic soda, driving off the un-converted aniline by a current of steam, separation of the melted violanilin base from the water (formed by condensation of steam), powdering, and drying it. (google.pl)
  • Aberrant control of motoneuronal excitability in amyotrophic lateral sclerosis: excitatory glutamate/D-serine vs. inhibitory glycine/gamma-aminobutanoic acid (GABA). (harvard.edu)
  • By the treatment of these bases and their salts with oil of vitriol, as described above, the four conjugated acids and their salts may be produced. (google.pl)
  • Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the amino caproic acid structure. (nih.gov)
  • 1.Catalytic-allylation of unprotected amino acid esters Ping Fang, Mani Raj Chaulagain, Zachary D. Aron* Org. (cas.cn)
  • In organic chemistry he published papers on the decomposition of ammonium oxalate , with formation of oxamic acid, on amyl alcohol , on the cyanides , and on the difference in constitution between ethyl nitrate and ethyl sulfate . (detailedpedia.com)
  • It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM. (rush.edu)
  • This graph shows the total number of publications written about "Oxamic Acid" by people in this website by year, and whether "Oxamic Acid" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Oxamic Acid" by people in Profiles. (umassmed.edu)
  • Alkylhydroxamic acids collector is a kind of efficiency chelating agents,and it can used in flotation process of various types of oxidative minerals, such as tin stone and tungstite. (xinhaimining.com)
  • During tin ore flotation process, the splenic acids collectors can react with tin ore and form solid compounds on the surface of minerals. (xinhaimining.com)
  • A non-essential amino acid that occurs in high levels in its free state in plasma. (rush.edu)
  • when using he benzohydroxamic acid, it should be add a certain amount of Fe 3+ in the mineral slurry to improve the activation effect, which can get a high recovery rate of tin ore. (xinhaimining.com)
  • Glutamic acid is the most common excitatory neurotransmitter in the brain. (harvard.edu)
  • Oxamate, the conjugate base of oxamic acid Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). (wikipedia.org)
  • Amino Acids, Neutral" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Amino acids with uncharged R groups or side chains. (harvard.edu)
  • This graph shows the total number of publications written about "Amino Acids, Neutral" by people in Harvard Catalyst Profiles by year, and whether "Amino Acids, Neutral" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Amino Acids, Neutral" by people in Profiles. (harvard.edu)
  • The compounds are formed from amino acids, ATP and transfer RNA , a reaction catalyzed by aminoacyl tRNA synthetase. (nih.gov)
  • Oxamic acid inhibits lactate dehydrogenase A. The active site of lactate dehydrogenase (LDH) is closed off once oxamic acid attaches to the LDH-NADH complex, effectively inhibiting it. (wikipedia.org)
  • 19. Generation of oxamic acid libraries: antimalarials and inhibitors of Plasmodium falciparum lactate dehydrogenase. (nih.gov)
  • Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A ( LDH-A ) inhibitor. (medchemexpress.com)
  • Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis . (medchemexpress.com)
  • DCVC and TCVC have previously been demonstrated to be mutagenic by the Ames Salmonella mutagenicity assay, and reduction in mutagenicity was observed upon treatment with the ýý-lyase inhibitor aminooxyacetic acid (AOAA). (nih.gov)
  • Oxamate, the conjugate base of oxamic acid Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). (wikipedia.org)
  • 16. Oxamic acid analogues as LDH-C4-specific competitive inhibitors. (nih.gov)
  • This review is focused on our efforts towards the design and synthesis of various families of potential inhibitors, including N-β-Dglucopyranosyl oxamic acid esters and oxamides, N-β-D-glucopyranosylaminocarbonyl L-aminoacids and peptides, as well as glucose-derived purine and pyrimidine nucleosides, spiro- and other bicyclic derivatives. (eurekaselect.com)
  • We also examine the effect of known ligands pyridoxal 5'-phosphate and aminooxyacetic acid on stability. (nih.gov)
  • A group of compounds that are derivatives of aminohexanoic acids. (wakehealth.edu)