Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
Nonsusceptibility of an organism to the action of penicillins.
A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Enzymes that cause coagulation in plasma by forming a complex with human PROTHROMBIN. Coagulases are produced by certain STAPHYLOCOCCUS and YERSINIA PESTIS. Staphylococci produce two types of coagulase: Staphylocoagulase, a free coagulase that produces true clotting of plasma, and Staphylococcal clumping factor, a bound coagulase in the cell wall that induces clumping of cells in the presence of fibrinogen.
Infections with bacteria of the genus STAPHYLOCOCCUS.
A semi-synthetic antibiotic related to penicillin.
One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.
Substances that reduce the growth or reproduction of BACTERIA.
A semisynthetic cephamycin antibiotic resistant to beta-lactamase.
One of the PENICILLINS which is resistant to PENICILLINASE.
Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.
A strain of Staphylococcus aureus that is non-susceptible to the action of METHICILLIN. The mechanism of resistance usually involves modification of normal or the presence of acquired PENICILLIN BINDING PROTEINS.
Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed)
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
A species of STAPHYLOCOCCUS that is a spherical, non-motile, gram-positive, chemoorganotrophic, facultative anaerobe. Mainly found on the skin and mucous membrane of warm-blooded animals, it can be primary pathogen or secondary invader.
A cephalosporin antibiotic.
Enzyme which catalyzes the peptide cross-linking of nascent CELL WALL; PEPTIDOGLYCAN.
Proteins found in any species of bacterium.
Enzymes that catalyze the transfer of hexose groups. EC 2.4.1.-.
Acyltransferases that use AMINO ACYL TRNA as the amino acid donor in formation of a peptide bond. There are ribosomal and non-ribosomal peptidyltransferases.
A method where a culturing surface inoculated with microbe is exposed to small disks containing known amounts of a chemical agent resulting in a zone of inhibition (usually in millimeters) of growth of the microbe corresponding to the susceptibility of the strain to the agent.
A species of STAPHYLOCOCCUS found on the skin of humans (and non-human primates), often causing hospital-acquired infections (CROSS INFECTION).
A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.
A 25-kDa peptidase produced by Staphylococcus simulans which cleaves a glycine-glcyine bond unique to an inter-peptide cross-bridge of the STAPHYLOCOCCUS AUREUS cell wall. EC 3.4.24.75.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.
A species of gram-positive bacteria in the family STAPHYLOCOCCACEAE. It commonly causes urinary tract infections in humans.
A cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.
Colorless, endogenous or exogenous pigment precursors that may be transformed by biological mechanisms into colored compounds; used in biochemical assays and in diagnosis as indicators, especially in the form of enzyme substrates. Synonym: chromogens (not to be confused with pigment-synthesizing bacteria also called chromogens).
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Bacteria which retain the crystal violet stain when treated by Gram's method.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
The action of a drug in promoting or enhancing the effectiveness of another drug.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
Nonsusceptibility of bacteria to the action of VANCOMYCIN, an inhibitor of cell wall synthesis.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.
The functional hereditary units of BACTERIA.
A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
Skin diseases caused by bacteria.
Glycopeptide antibiotic complex from Actinoplanes teichomyceticus active against gram-positive bacteria. It consists of five major components each with a different fatty acid moiety.
A sweet viscous liquid food, produced in the honey sacs of various bees from nectar collected from flowers. The nectar is ripened into honey by inversion of its sucrose sugar into fructose and glucose. It is somewhat acidic and has mild antiseptic properties, being sometimes used in the treatment of burns and lacerations.
Pneumonia caused by infections with bacteria of the genus STAPHYLOCOCCUS, usually with STAPHYLOCOCCUS AUREUS.
A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Any infection which a patient contracts in a health-care institution.
A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.
The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.
Antioxidant for foods, fats, oils, ethers, emulsions, waxes, and transformer oils.
The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
Derivatives of acetamide that are used as solvents, as mild irritants, and in organic synthesis.
Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.
A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.
Techniques used in studying bacteria.
A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
A ubiquitous sodium salt that is commonly used to season food.
A genus of gram-positive, coccoid bacteria consisting of organisms causing variable hemolysis that are normal flora of the intestinal tract. Previously thought to be a member of the genus STREPTOCOCCUS, it is now recognized as a separate genus.
Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.
Infections to the skin caused by bacteria of the genus STAPHYLOCOCCUS.
Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.
An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.
Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
A cyclic polypeptide antibiotic complex from Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others. It consists of 2 major components, VIRGINIAMYCIN FACTOR M1 and virginiamycin Factor S1. It is used to treat infections with gram-positive organisms and as a growth promoter in cattle, swine, and poultry.
A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Rupture of bacterial cells due to mechanical force, chemical action, or the lytic growth of BACTERIOPHAGES.
Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.
Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
Method of measuring the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy. It is used to monitor the therapy in BACTERIAL ENDOCARDITIS; OSTEOMYELITIS and other serious bacterial infections. As commonly performed, the test is a variation of the broth dilution test. This test needs to be distinguished from testing of the naturally occurring BLOOD BACTERICIDAL ACTIVITY.
Coccus-shaped bacteria that retain the crystal violet stain when treated by Gram's method.
An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.
Transport proteins that carry specific substances in the blood or across cell membranes.
A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.
A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Peptidoglycan is a complex polymer found in the cell walls of bacteria, composed of sugars and amino acids, that provides structural support and protection against external stresses.
An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)
Therapy with two or more separate preparations given for a combined effect.
Invasion of the site of trauma by pathogenic microorganisms.
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate.
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Simultaneous resistance to several structurally and functionally distinct drugs.
An enzyme that catalyzes the endonucleolytic cleavage to 3'-phosphomononucleotide and 3'-phospholigonucleotide end-products. It can cause hydrolysis of double- or single-stranded DNA or RNA. (From Enzyme Nomenclature, 1992) EC 3.1.31.1.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.
Osteomyelitis is an infection of the bone and bone marrow, typically caused by bacteria or fungi.
Elements of limited time intervals, contributing to particular results or situations.
A broad-spectrum antimicrobial carboxyfluoroquinoline.
Semisynthetic broad-spectrum cephalosporin.
Negative test results in subjects who possess the attribute for which the test is conducted. The labeling of diseased persons as healthy when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Measurable quantity of bacteria in an object, organism, or organism compartment.
Brazil is a country in South America known for its high rates of infectious diseases such as dengue fever, Zika virus, and chikungunya, as well as its successful vaccination programs.
Institutions with an organized medical staff which provide medical care to patients.
The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.
The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.
Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.
A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.
Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.
Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Infections by bacteria, general or unspecified.
Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
Persons who receive ambulatory care at an outpatient department or clinic without room and board being provided.
The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
An infant during the first month after birth.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

Evaluation of MRSA-Screen, a simple anti-PBP 2a slide latex agglutination kit, for rapid detection of methicillin resistance in Staphylococcus aureus. (1/449)

The MRSA-Screen test (Denka Seiken Co., Ltd., Tokyo, Japan), consisting of a slide latex agglutination kit that detects PBP 2a with a monoclonal antibody, was blindly compared to the oxacillin disk diffusion test, the oxacillin-salt agar screen, and PCR of the mecA gene for the detection of methicillin resistance in Staphylococcus aureus. A total of 120 methicillin-susceptible S. aureus (MSSA) and 80 methicillin-resistant S. aureus (MRSA) isolates, defined by the absence or presence of the mecA gene, respectively, were tested. The MRSA-Screen test, the oxacillin disk diffusion test, and the oxacillin-salt agar screening test showed sensitivities of 100, 61.3, and 82.5% and specificities of 99.2, 96.7, and 98.3%, respectively. We conclude that the MRSA-Screen is a very accurate, reliable, and fast test (15 min) for differentiation of MRSA from MSSA colonies on agar plates.  (+info)

Misclassification of susceptible strains of Staphylococcus aureus as methicillin-resistant S. aureus By a rapid automated susceptibility testing system. (2/449)

Eight Staphylococcus aureus strains initially identified by Vitek GPS-BS or GPS-SA cards as resistant to oxacillin, but susceptible to most non-beta-lactam antibiotics, were found on further testing to be susceptible to oxacillin and ceftizoxime by disk diffusion tests. For all these strains, the MICs of oxacillin were +info)

Oxacillin susceptibility testing of staphylococci directly from Bactec Plus blood cultures by the BBL Crystal MRSA ID system. (3/449)

The BBL Crystal MRSA ID test (Becton Dickinson) was applied directly to blood culture vials containing clusters of gram-positive cocci. The sensitivity and specificity of the test were 84 and 100% and 54 and 100% for vials containing Staphylococcus aureus and coagulase-negative staphylococci, respectively. This test is a reliable method for direct detection of methicillin resistance in positive blood culture vials when S. aureus is identified in parallel by rapid identification procedures.  (+info)

Disk with high oxacillin content discriminates between methicillin-resistant and borderline methicillin-susceptible Staphylococcus aureus strains in disk diffusion assays using a low salt concentration. (4/449)

A separation between mecA+ strains of Staphylococcus aureus and strains lacking mecA was achieved by the disk diffusion assay and the agar dilution method, utilizing disks containing 5 microg of oxacillin and inocula of approximately 5 x 10(5) CFU/spot, respectively, provided that agar with 0 to 0.5% NaCl and incubation at 30 degrees C were employed. The 5-microg oxacillin disks clearly discriminated between borderline methicillin-susceptible and mecA+ strains. The oxacillin MICs were more affected by the inoculum density and salt concentration than were the methicillin MICs, and oxacillin MICs of 4 to 16 microg/ml were obtained for strains lacking mecA. Significantly higher levels of beta-lactamase production and reduced oxacillin susceptibilities were recorded for strains lacking mecA, in particular strains of phage group V, when agar with >/=2% NaCl was used than when agar with 0 to 0.5% NaCl was employed. The results indicate that the borderline methicillin-susceptible phenotype is a salt-dependent in vitro phenomenon of questionable clinical relevance.  (+info)

Evaluation of a new 3-h hybridization method for detecting the mecA gene in Staphylococcus aureus and comparison with existing genotypic and phenotypic susceptibility testing methods. (5/449)

A new 3-h hybridization assay for detection of the staphylococcal mecA gene and the Staphylococcus aureus nuclease gene was evaluated by comparing the assay with existing genotypic and phenotypic methods. A total of 275 S. aureus strains were tested, including 257 epidemiologically unrelated strains (135 mecA-positive and 122 mecA-negative; collection I), and 18 strains with known borderline resistance to methicillin (collection II). Complete agreement was obtained for both collections when comparing the new assay with genotypic methods. We further evaluated a range of phenotypic susceptibility methods recommended in Europe and/or USA using the presence of the mecA gene as the defining standard. For collection I a high degree of agreement was found for both Etests (256 strains) and the oxacillin screen plate test (255 strains); the degree of agreement was lower for agar dilution methicillin (250 strains) and oxacillin 1 microg discs (239 strains). For the borderline strains a high degree of agreement was only obtained by the oxacillin screen plate test (17 of 18 strains). The other tests were less accurate, in the following order: agar dilution methicillin, Etest methicillin, Etest oxacillin and oxacillin discs with disagreement for four, five, nine and 13 strains, respectively. In conclusion, the new hybridization assay is a rapid and exact method for detecting the mecA gene and the S. aureus nuclease gene. This study confirms that phenotypic tests for methicillin resistance in S. aureus strains creates both false-susceptible and false-resistant results, especially for borderline resistant strains.  (+info)

Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. (6/449)

Coagulase-negative staphylococcal isolates (n = 188) were screened for susceptibility to oxacillin, ciprofloxacin, and trovafloxacin, a new fluoroquinolone. At an oxacillin concentration of >/=4 microg/ml, 43% were methicillin resistant; of these, 70% were ciprofloxacin resistant (MIC, >/=4 microg/ml). Of the methicillin-resistant, ciprofloxacin-resistant isolates, 46% were susceptible to /=8 microg/ml) and increased trovafloxacin MICs (0.25 to 2 microg/ml) could be conferred by the combined presence of single mutations in each gyrA and grlA gene. Trovafloxacin MICs of >/=8 microg/ml also occurred, but these required an additional mutation in grlA.  (+info)

Comparative efficacies of liposomal amikacin (MiKasome) plus oxacillin versus conventional amikacin plus oxacillin in experimental endocarditis induced by Staphylococcus aureus: microbiological and echocardiographic analyses. (7/449)

Optimal treatment strategies for serious infections caused by Staphylococcus aureus have not been fully characterized. The combination of a beta-lactam plus an aminoglycoside can act synergistically against S. aureus in vitro and in vivo. MiKasome, a new liposome-encapsulated formulation of conventional amikacin, significantly prolongs serum half-life (t1/2) and increases the area under the concentration-time curve (AUC) compared to free amikacin. Microbiologic efficacy and left ventricular function, as assessed by echocardiography, were compared in animals administered either oxacillin alone or oxacillin in combination with conventional amikacin or MiKasome in a rabbit model of experimental endocarditis due to S. aureus. In vitro, oxacillin, combined with either free amikacin or MiKasome, prevented the bacterial regrowth observed with aminoglycosides alone at 24 h of incubation. Rabbits with S. aureus endocarditis were treated with either oxacillin alone (50 mg/kg, given intramuscularly three times daily), oxacillin plus daily amikacin (27 mg/kg, given intravenously twice daily), or oxacillin plus intermittent MiKasome (160 mg/kg, given intravenously, a single dose on days 1 and 4). The oxacillin-alone dosage represents a subtherapeutic regimen against the infecting strain in the endocarditis model (L. Hirano and A. S. Bayer, Antimicrob. Agents Chemother. 35:685-690, 1991), thus allowing recognition of any enhanced bactericidal effects between oxacillin and either aminoglycoside formulation. Treatment was administered for either 3 or 6 days, and animals were sacrificed after each of these time points or at 5 days after a 6-day treatment course (to evaluate for posttherapy relapse). Left ventricular function was analyzed by utilizing serial transthoracic echocardiography during treatment and posttherapy by measurement of left ventricular fractional shortening. At all sacrifice times, both combination regimens significantly reduced S. aureus vegetation counts versus control counts (P < 0.05). In contrast, oxacillin alone did not significantly reduce S. aureus vegetation counts after 3 days of therapy. Furthermore, at this time point, the two combinations were significantly more effective than oxacillin alone (P < 0.05). All three regimens were effective in significantly decreasing bacterial counts in the myocardium during and after therapy compared to controls (P < 0.05). In kidney and spleen abscesses, all regimens significantly reduced bacterial counts during therapy (P < 0.0001); however, only the combination regimens prevented bacteriologic relapse in these organs posttherapy. By echocardiographic analysis, both combination regimens yielded a significant physiological benefit by maintaining normal left ventricular function during treatment and posttherapy compared with oxacillin alone (P < 0.001). These results suggest that the use of intermittent MiKasome (similar to daily conventional amikacin) enhances the in vivo bactericidal effects of oxacillin in a severe S. aureus infection model and preserves selected physiological functions in target end organs.  (+info)

Methicillin-resistant Staphylococcus aureus clonal types in the Czech Republic. (8/449)

Molecular surveillance studies have documented the extensive spread of methicillin-resistant Staphylococcus aureus (MRSA) clones. Studies carried out by Centro de Epidemiologia Molecular-Network for Tracking Gram-Positive Pathogenic Bacteria (CEM/NET) led to the identification of two international multidrug-resistant strains, which were designated as the Iberian and Brazilian MRSA clones and which were defined by multiple genomic typing methods; these included ClaI restriction digests hybridized with mecA- and Tn554-specific DNA probes and pulsed-field gel electrophoresis (PFGE). The genotypic characteristics of these clones are distinct: the Iberian clone is defined as mecA type I, Tn554 type E (or its variants), and PFGE pattern A (I:E:A), whereas the Brazilian clone is defined as mecA type XI (or its variants), Tn554 type B, and PFGE pattern B (XI:B:B). In this study, we characterized 59 single-patient isolates of MRSA collected during 1996 and 1997 at seven hospitals located in Prague and five other cities in the Czech Republic by using the methodologies mentioned above and by using ribotyping of EcoRI and HindIII digests hybridized with a 16S-23S DNA probe. The Brazilian MRSA clone (XI:B:B) was the major clone (80%) spread in two hospitals located in Prague and one located in Brno; the Iberian MRSA clone (I:E:A or its variant I:DD:A), although less representative (12%), was detected in two hospitals, one in Prague and the other in Plzen. Almost all the strains belonging to clone XI:B:B (45 of 47) corresponded to a unique ribotype, E1H1, whereas most strains of the I:E:A and I:DD:A clonal types (6 of 7) corresponded to ribotype E2H2.  (+info)

Penicillins are a group of antibiotics that are derived from the Penicillium fungi. They are one of the most widely used antibiotics in the medical field and are effective against a variety of bacterial infections, including pneumonia, strep throat, and urinary tract infections. Penicillins work by inhibiting the production of cell walls in bacteria, which causes the bacteria to burst and die. There are several different types of penicillins, including penicillin G, penicillin V, amoxicillin, and cephalosporins, which have different properties and are used to treat different types of infections. Penicillins are generally well-tolerated by most people, but can cause side effects such as allergic reactions, diarrhea, and nausea. It is important to take penicillins exactly as prescribed by a healthcare provider and to finish the full course of treatment, even if symptoms improve before the medication is finished.

Coagulase is an enzyme produced by certain strains of bacteria, including Staphylococcus aureus, that is responsible for the conversion of fibrinogen to fibrin, a key step in the clotting of blood. The presence of coagulase in a bacterial culture is often used as a diagnostic test to identify S. aureus infections, as this enzyme is not produced by most other types of bacteria. In addition to its role in blood clotting, coagulase has also been shown to play a role in the pathogenesis of S. aureus infections, including the ability of the bacteria to form biofilms and evade the host immune system.

Staphylococcal infections are caused by bacteria of the genus Staphylococcus. These bacteria are commonly found on the skin and in the nose of healthy individuals, but can sometimes cause infections when they enter the body through cuts, wounds, or other openings. Staphylococcal infections can range from mild skin infections like impetigo to more serious infections like pneumonia, sepsis, and meningitis. Some types of staphylococcal bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), are resistant to certain antibiotics and can be more difficult to treat. Treatment for staphylococcal infections typically involves antibiotics, although in some cases surgery may be necessary.

Nafcillin is an antibiotic medication that is used to treat a variety of bacterial infections. It is a member of the penicillin group of antibiotics, which work by inhibiting the growth of bacteria. Nafcillin is typically used to treat infections of the skin, respiratory tract, urinary tract, and bones and joints. It is usually given by injection, although it can also be taken by mouth in some cases. Nafcillin is generally considered to be effective against a wide range of bacteria, including many that are resistant to other antibiotics. However, it is important to note that nafcillin may not be effective against all types of bacteria, and it is important to use the medication as directed by a healthcare provider.

Methicillin is an antibiotic medication that is used to treat a variety of bacterial infections, including pneumonia, skin infections, and urinary tract infections. It is a member of the penicillin group of antibiotics and is effective against many types of bacteria that are resistant to other antibiotics. Methicillin works by inhibiting the growth of bacteria by interfering with the synthesis of their cell walls. It is typically administered orally or intravenously, depending on the severity of the infection and the patient's condition. However, it is important to note that methicillin-resistant Staphylococcus aureus (MRSA) is a type of bacteria that has become resistant to methicillin and other antibiotics in the penicillin group. As a result, it is important to use methicillin and other antibiotics judiciously and only when necessary to prevent the development of antibiotic resistance.

Anti-bacterial agents, also known as antibiotics, are medications that are used to treat bacterial infections. They work by killing or inhibiting the growth of bacteria, thereby preventing the spread of the infection. There are several types of anti-bacterial agents, including: 1. Penicillins: These are the first antibiotics discovered and are effective against a wide range of bacteria. 2. Cephalosporins: These are similar to penicillins and are effective against many of the same types of bacteria. 3. Macrolides: These antibiotics are effective against bacteria that are resistant to other antibiotics. 4. Tetracyclines: These antibiotics are effective against a wide range of bacteria and are often used to treat acne. 5. Fluoroquinolones: These antibiotics are effective against a wide range of bacteria and are often used to treat respiratory infections. It is important to note that antibiotics are only effective against bacterial infections and are not effective against viral infections such as the common cold or flu. Additionally, overuse or misuse of antibiotics can lead to the development of antibiotic-resistant bacteria, which can be more difficult to treat.

Cefoxitin is an antibiotic medication that is used to treat a variety of bacterial infections. It is a member of the cephalosporin class of antibiotics, which work by inhibiting the growth of bacteria. Cefoxitin is typically used to treat infections of the skin, respiratory tract, urinary tract, and abdomen. It is usually given intravenously, although it can also be given by mouth in some cases. Cefoxitin is generally well-tolerated, but like all antibiotics, it can cause side effects such as nausea, diarrhea, and allergic reactions. It is important to take cefoxitin exactly as prescribed by a healthcare provider in order to ensure that it is effective and to minimize the risk of side effects.

Dicloxacillin is an antibiotic medication that belongs to the penicillin group of antibiotics. It is used to treat a variety of bacterial infections, including skin infections, respiratory infections, urinary tract infections, and bone and joint infections. Dicloxacillin is typically taken orally, but it can also be given intravenously in severe cases. It works by inhibiting the growth of bacteria by interfering with the synthesis of their cell walls. Like other penicillins, dicloxacillin can cause allergic reactions in some people, so it is important to let your doctor know if you have any allergies or if you experience any adverse reactions while taking the medication.

Penicillin-Binding Proteins (PBPs) are enzymes found in the cell walls of bacteria that are responsible for cross-linking peptidoglycan strands, which is a key component of bacterial cell walls. PBPs are targeted by many antibiotics, including penicillins, cephalosporins, and carbapenems, which inhibit their activity and prevent the formation of a stable cell wall, leading to bacterial cell lysis and death. PBPs are classified into several classes based on their molecular weight and substrate specificity. Class A PBPs are the most common and are found in most bacteria, including Gram-positive and Gram-negative bacteria. Class B PBPs are found only in Gram-positive bacteria, while class C PBPs are found only in Gram-negative bacteria. Class D PBPs are found in both Gram-positive and Gram-negative bacteria and are responsible for resistance to beta-lactam antibiotics. In summary, PBPs are essential enzymes for bacterial cell wall synthesis and are targeted by many antibiotics, making them important targets for the development of new antibiotics to combat bacterial infections.

Vancomycin is an antibiotic medication that is used to treat a variety of bacterial infections, including severe skin infections, pneumonia, and bloodstream infections. It is particularly effective against bacteria that are resistant to other antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA). Vancomycin works by inhibiting the growth of bacteria by interfering with the synthesis of their cell walls. It is typically administered intravenously, although it can also be given orally in some cases. Vancomycin is a powerful antibiotic, and it is important to use it only when it is necessary and to follow the prescribed dosage and duration of treatment. Overuse or misuse of vancomycin can lead to the development of antibiotic-resistant bacteria, which can be more difficult to treat.

Cephalothin is an antibiotic medication that belongs to the penicillin group of drugs. It is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, and skin infections. Cephalothin is typically administered intravenously or intramuscularly, and it works by inhibiting the growth and reproduction of bacteria. It is important to note that cephalothin may not be effective against all types of bacteria, and it can also cause side effects such as allergic reactions, nausea, and diarrhea.

Muramoylpentapeptide Carboxypeptidase (MCP) is an enzyme that plays a crucial role in the metabolism of bacterial cell walls. It is a zinc-dependent metalloprotease that cleaves the terminal alanine residue from the pentapeptide side chain of muramic acid, a component of peptidoglycan, the main structural component of bacterial cell walls. MCP is produced by a variety of bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis. It is involved in the regulation of cell wall biosynthesis and plays a role in bacterial pathogenesis. Inhibition of MCP activity has been shown to have potential therapeutic applications in the treatment of bacterial infections. In the medical field, MCP is often studied as a target for the development of new antibiotics and antimicrobial agents. Additionally, MCP has been shown to be involved in the pathogenesis of certain diseases, such as tuberculosis and pneumonia, and may be a potential target for the development of new treatments for these conditions.

Bacterial proteins are proteins that are synthesized by bacteria. They are essential for the survival and function of bacteria, and play a variety of roles in bacterial metabolism, growth, and pathogenicity. Bacterial proteins can be classified into several categories based on their function, including structural proteins, metabolic enzymes, regulatory proteins, and toxins. Structural proteins provide support and shape to the bacterial cell, while metabolic enzymes are involved in the breakdown of nutrients and the synthesis of new molecules. Regulatory proteins control the expression of other genes, and toxins can cause damage to host cells and tissues. Bacterial proteins are of interest in the medical field because they can be used as targets for the development of antibiotics and other antimicrobial agents. They can also be used as diagnostic markers for bacterial infections, and as vaccines to prevent bacterial diseases. Additionally, some bacterial proteins have been shown to have therapeutic potential, such as enzymes that can break down harmful substances in the body or proteins that can stimulate the immune system.

Hexosyltransferases are a group of enzymes that transfer a hexose sugar moiety from a donor molecule to an acceptor molecule. These enzymes play a crucial role in the biosynthesis of various complex carbohydrates, such as glycans, glycoproteins, and glycolipids, which are essential components of cell membranes and extracellular matrix. In the medical field, hexosyltransferases are involved in various diseases and disorders, including cancer, diabetes, and autoimmune diseases. For example, mutations in certain hexosyltransferase genes can lead to the development of inherited disorders such as glycogen storage diseases, which are characterized by the accumulation of abnormal glycogen in various tissues. In addition, hexosyltransferases are also important targets for the development of new drugs and therapies. For instance, inhibitors of hexosyltransferases have been shown to have anti-cancer properties by disrupting the biosynthesis of glycoproteins and glycolipids that are involved in tumor growth and metastasis.

Peptidyl transferases are enzymes that catalyze the formation of peptide bonds between amino acids during protein synthesis. They are responsible for the elongation of polypeptide chains by transferring the growing polypeptide chain from the ribosome's A site to the P site, where it is joined to the next amino acid. Peptidyl transferases are essential for the proper functioning of ribosomes, which are the cellular machinery responsible for protein synthesis. There are two main types of peptidyl transferases: ribosomal peptidyl transferases, which are found in ribosomes, and non-ribosomal peptidyl transferases, which are found in various cellular compartments and are involved in the synthesis of non-proteinogenic peptides.

Cloxacillin is an antibiotic medication that is used to treat a variety of bacterial infections, including pneumonia, skin infections, urinary tract infections, and infections of the bones and joints. It is a type of penicillin antibiotic, which works by inhibiting the growth of bacteria. Cloxacillin is typically administered orally or intravenously, and it is usually taken for several days or until the infection has cleared up. It is important to follow the dosing instructions provided by your healthcare provider and to complete the full course of treatment, even if you start to feel better before the medication is finished. Like all antibiotics, cloxacillin can cause side effects, such as nausea, vomiting, diarrhea, and allergic reactions. It is important to tell your healthcare provider if you experience any side effects while taking cloxacillin.

Lysostaphin is a protein that is produced by certain bacteria, including Staphylococcus aureus. It is a protease that specifically cleaves the peptide bond between the alanine and valine residues in the cell wall of certain bacteria, including Staphylococcus aureus and Streptococcus pneumoniae. This cleavage weakens the cell wall and makes the bacteria more susceptible to lysis or destruction by other antibiotics or the host immune system. Lysostaphin has been studied as a potential therapeutic agent for the treatment of bacterial infections, particularly those caused by antibiotic-resistant strains of Staphylococcus aureus.

In the medical field, agar is a gelatinous substance that is commonly used as a growth medium for bacteria, fungi, and other microorganisms. It is made from seaweed and is composed of agarose, a polysaccharide that forms a gel when heated. Agar is often used in microbiology laboratories to culture and isolate microorganisms, as well as to study their growth and behavior. It is also used in some medical treatments, such as in the preparation of certain types of vaccines and in the treatment of certain skin conditions.

Gentamicins are a group of antibiotics that are commonly used to treat a wide range of bacterial infections. They are derived from the bacterium Streptomyces griseus and are classified as aminoglycosides. Gentamicins are effective against many gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. They are also effective against some gram-positive bacteria, such as Staphylococcus aureus and Enterococcus faecalis. Gentamicins are typically administered intravenously, although they can also be given intramuscularly or topically. They are often used to treat severe infections, such as sepsis, meningitis, and pneumonia. Gentamicins are also used to treat infections in the urinary tract, skin, and soft tissues. However, gentamicins can have serious side effects, including hearing loss, kidney damage, and nerve damage. They should only be used under the supervision of a healthcare professional and with careful monitoring of the patient's response to treatment.

In the medical field, culture media refers to a nutrient-rich substance used to support the growth and reproduction of microorganisms, such as bacteria, fungi, and viruses. Culture media is typically used in diagnostic laboratories to isolate and identify microorganisms from clinical samples, such as blood, urine, or sputum. Culture media can be classified into two main types: solid and liquid. Solid media is usually a gel-like substance that allows microorganisms to grow in a three-dimensional matrix, while liquid media is a broth or solution that provides nutrients for microorganisms to grow in suspension. The composition of culture media varies depending on the type of microorganism being cultured and the specific needs of that organism. Culture media may contain a variety of nutrients, including amino acids, sugars, vitamins, and minerals, as well as antibiotics or other agents to inhibit the growth of unwanted microorganisms. Overall, culture media is an essential tool in the diagnosis and treatment of infectious diseases, as it allows healthcare professionals to identify the specific microorganisms causing an infection and select the most appropriate treatment.

Endocarditis, bacterial is an infection of the inner lining of the heart (endocardium) and the heart valves. It is caused by bacteria that enter the bloodstream and attach themselves to the heart valves or other areas of the heart. The infection can cause inflammation, damage to the heart valves, and the formation of scar tissue, which can lead to heart failure or other complications. Bacterial endocarditis is typically treated with antibiotics, but surgery may be necessary in some cases to repair or replace damaged heart valves. It is a serious condition that requires prompt medical attention.

Daptomycin is an antibiotic medication that is used to treat certain bacterial infections. It is a member of a class of antibiotics called lipopeptides, which are made up of a combination of amino acids and fatty acids. Daptomycin works by inhibiting the growth of bacteria by disrupting their cell membranes, which prevents them from taking up essential nutrients and ultimately leads to their death. It is typically used to treat infections caused by Gram-positive bacteria, such as Staphylococcus aureus and Streptococcus pneumoniae. Daptomycin is usually administered intravenously, although it is also available in an oral form. It is generally well-tolerated, although it can cause side effects such as nausea, vomiting, and diarrhea.

Chromogenic compounds are substances that undergo a change in color when they react with a specific substance or under certain conditions. In the medical field, chromogenic compounds are often used in diagnostic tests to detect the presence of specific substances or to identify certain diseases. For example, some chromogenic compounds are used in urine tests to detect the presence of certain drugs or to identify urinary tract infections. Other chromogenic compounds are used in blood tests to detect the presence of specific enzymes or to identify certain types of cancer. Chromogenic compounds are also used in histology, the study of tissue samples, to stain specific structures or cells and make them more visible under a microscope. This can be useful in identifying certain diseases or conditions, such as cancer or infections. Overall, chromogenic compounds are an important tool in the medical field, allowing healthcare professionals to quickly and accurately diagnose and treat a wide range of conditions.

Ampicillin is a type of antibiotic medication that is used to treat a variety of bacterial infections. It is a penicillin antibiotic, which means that it works by inhibiting the growth of bacteria by interfering with their ability to make cell walls. Ampicillin is effective against a wide range of bacteria, including Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli. It is often used to treat infections of the respiratory tract, urinary tract, and skin and soft tissues. Ampicillin is usually administered orally or intravenously, and it is generally well-tolerated by most people. However, like all antibiotics, it can cause side effects such as nausea, diarrhea, and allergic reactions.

Beta-Lactams are a class of antibiotics that are derived from the beta-lactam ring structure. They are one of the most widely used classes of antibiotics and are effective against a broad range of bacterial infections. The beta-lactam ring is a six-membered ring with a beta-hydroxy group and an amide group. The beta-lactam antibiotics work by inhibiting the synthesis of the bacterial cell wall, which leads to cell lysis and death. There are several subclasses of beta-lactam antibiotics, including penicillins, cephalosporins, monobactams, and carbapenems. Each subclass has its own unique properties and is effective against different types of bacteria. Beta-lactam antibiotics are often used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, skin infections, and infections of the respiratory, gastrointestinal, and genitourinary tracts. They are generally well-tolerated and have a low risk of side effects, although allergic reactions can occur in some people.

Cephalosporins are a class of antibiotics that are derived from the mold species Cephalosporium acremonium. They are commonly used to treat a wide range of bacterial infections, including respiratory tract infections, skin infections, urinary tract infections, and infections of the bones and joints. Cephalosporins work by inhibiting the synthesis of bacterial cell walls, which leads to the death of the bacteria. They are generally well-tolerated and have a broad spectrum of activity against many types of bacteria. There are several different classes of cephalosporins, each with its own specific characteristics and uses. The most commonly used classes are first-generation cephalosporins, second-generation cephalosporins, third-generation cephalosporins, and fourth-generation cephalosporins. The choice of which cephalosporin to use depends on the type of infection being treated, the severity of the infection, and the specific characteristics of the bacteria causing the infection.

Beta-lactamases are enzymes produced by certain bacteria that are responsible for breaking down beta-lactam antibiotics, which are a class of antibiotics that include penicillins, cephalosporins, and monobactams. These enzymes hydrolyze the beta-lactam ring of the antibiotic, rendering it inactive and unable to kill the bacteria. The production of beta-lactamases is a common mechanism of antibiotic resistance in bacteria, and it has become a major problem in the treatment of bacterial infections. Bacteria that produce beta-lactamases are often referred to as "beta-lactamase-producing organisms" or "BLPOs." There are different types of beta-lactamases, and they can be classified based on their substrate specificity, molecular weight, and resistance profile. Some beta-lactamases are specific for a particular class of beta-lactam antibiotics, while others are more broad-spectrum and can hydrolyze multiple classes of antibiotics. The detection and characterization of beta-lactamases is important for the appropriate selection and use of antibiotics in the treatment of bacterial infections. In addition, the development of new antibiotics that are resistant to beta-lactamases is an ongoing area of research in the medical field.

Sulbactam is an antibiotic that is used in combination with beta-lactam antibiotics, such as penicillins and cephalosporins, to enhance their effectiveness against certain types of bacteria. It works by inhibiting the production of beta-lactamase enzymes, which are produced by some bacteria to inactivate beta-lactam antibiotics. By inhibiting these enzymes, sulbactam allows the beta-lactam antibiotic to remain active and effective against the bacteria. It is often used to treat infections caused by bacteria that are resistant to other antibiotics.

Mannitol is a naturally occurring sugar alcohol that is used in the medical field as a diuretic and osmotic agent. It is used to increase urine output and reduce intracranial pressure in patients with conditions such as brain injury, stroke, and elevated intracranial pressure. Mannitol is also used to treat dehydration, as well as to prevent and treat kidney stones. It is available in oral and intravenous forms and is generally considered safe when used as directed.

Skin diseases caused by bacteria are a common type of infection that can affect people of all ages and genders. These infections can range from mild to severe and can affect different parts of the body, including the face, neck, arms, legs, and torso. Some common bacterial skin diseases include acne, impetigo, cellulitis, folliculitis, and erysipelas. Acne is a common skin condition that affects the hair follicles and sebaceous glands, causing pimples, blackheads, and whiteheads. Impetigo is a highly contagious skin infection that usually affects children and is caused by the bacteria Streptococcus pyogenes or Staphylococcus aureus. Cellulitis is a serious skin infection that can spread quickly and cause swelling, redness, and pain. Folliculitis is an infection of the hair follicles that can cause redness, swelling, and pus-filled bumps. Erysipelas is a severe skin infection that can cause redness, swelling, and fever. Treatment for bacterial skin diseases typically involves the use of antibiotics, either topically or orally, depending on the severity of the infection. In some cases, hospitalization may be necessary for severe infections. It is important to seek medical attention if you suspect you have a bacterial skin infection, as untreated infections can lead to complications and spread to other parts of the body.

Teicoplanin is an antibiotic medication used to treat bacterial infections, particularly those caused by Gram-positive bacteria such as Staphylococcus aureus and Enterococcus species. It is a glycopeptide antibiotic, which means it works by inhibiting the growth of bacteria by interfering with their ability to synthesize cell walls. Teicoplanin is typically administered intravenously and is used to treat severe or life-threatening infections, such as endocarditis (infection of the heart valves), bone and joint infections, and pneumonia. It is also used as a prophylactic treatment to prevent infections in patients who are at high risk, such as those undergoing surgery or chemotherapy. Teicoplanin is generally well-tolerated, but like all antibiotics, it can cause side effects such as nausea, vomiting, diarrhea, and allergic reactions. It is important to take the full course of teicoplanin as prescribed by a healthcare provider to ensure that the infection is fully treated and to prevent the development of antibiotic resistance.

Pneumonia, Staphylococcal is a type of pneumonia caused by the bacterium Staphylococcus aureus. It is a serious infection that can affect people of all ages, but it is more common in older adults, infants, and people with weakened immune systems. Staphylococcus aureus is a common bacteria that can be found on the skin and in the nose of healthy people. However, when it enters the lungs, it can cause an infection that can be difficult to treat. Symptoms of Staphylococcal pneumonia may include fever, cough, chest pain, difficulty breathing, and fatigue. In severe cases, the infection can spread to other parts of the body, such as the bloodstream or the brain, which can be life-threatening. Treatment for Staphylococcal pneumonia typically involves antibiotics to kill the bacteria. In some cases, hospitalization may be necessary to provide supportive care, such as oxygen therapy or intravenous fluids. It is important to seek medical attention if you suspect you have Staphylococcal pneumonia, as prompt treatment can help prevent complications and improve outcomes.

Ceftriaxone is an antibiotic medication that is used to treat a variety of bacterial infections. It is a cephalosporin antibiotic, which means that it works by stopping the growth of bacteria. Ceftriaxone is often used to treat infections of the respiratory tract, urinary tract, and skin, as well as infections that affect the bones and joints, blood, and central nervous system. It is usually given by injection, although it is also available in an oral form. Ceftriaxone is a powerful antibiotic and can be effective against many types of bacteria, but it is important to use it only as directed by a healthcare provider to avoid the development of antibiotic resistance.

Penicillin G is a type of antibiotic medication that is derived from the Penicillium fungi. It is a beta-lactam antibiotic that works by inhibiting the growth of bacteria by interfering with their cell wall synthesis. Penicillin G is effective against a wide range of bacterial infections, including pneumonia, meningitis, and sepsis. It is typically administered intravenously or intramuscularly, and is often used as a first-line treatment for serious bacterial infections. However, it is important to note that Penicillin G is not effective against all types of bacteria, and may not be appropriate for use in certain individuals, such as those with penicillin allergies.

Thioridazine is an antipsychotic medication that was previously used to treat schizophrenia and other psychotic disorders. It works by blocking the action of dopamine in the brain, which can help to reduce symptoms such as hallucinations, delusions, and disorganized thinking. Thioridazine was first introduced in the 1950s and was widely used for many years. However, its use has been limited in recent years due to concerns about its safety. Thioridazine has been associated with a number of serious side effects, including an increased risk of heart rhythm problems, high blood pressure, and movement disorders such as tardive dyskinesia. In some countries, thioridazine is no longer available for use due to these safety concerns. In other countries, it may still be available but is typically reserved for use in patients who have not responded to other antipsychotic medications or who have certain medical conditions that make them more susceptible to the risks associated with thioridazine.

Cross infection is the transmission of an infectious agent from one person or animal to another through direct or indirect contact with contaminated objects, surfaces, or bodily fluids. It can occur in a variety of settings, including hospitals, schools, homes, and workplaces. Cross infection can be prevented through proper hygiene practices such as hand washing, using personal protective equipment (PPE), and disinfecting surfaces. It is also important to follow proper infection control procedures, such as isolation of infected individuals and proper disposal of contaminated materials. In the medical field, cross infection is a serious concern as it can lead to the spread of nosocomial infections, which are infections acquired in a healthcare setting. These infections can be particularly dangerous for patients with weakened immune systems or underlying medical conditions. Therefore, healthcare workers are trained to follow strict infection control protocols to prevent the spread of cross infection.

Penicillinase is an enzyme produced by certain bacteria that is capable of breaking down penicillin antibiotics, rendering them ineffective. Penicillinase is responsible for the development of resistance to penicillin in many bacterial strains, including Staphylococcus aureus and Streptococcus pneumoniae. The production of penicillinase is a mechanism by which bacteria can survive in the presence of penicillin, which would otherwise be lethal to them. In the medical field, penicillinase is an important factor to consider when selecting antibiotics for the treatment of bacterial infections, as it can reduce the effectiveness of penicillin and other beta-lactam antibiotics.

In the medical field, the cell wall is a rigid layer that surrounds the cell membrane of certain types of cells, such as plant cells and some bacteria. The cell wall provides structural support and protection to the cell, and helps to maintain its shape and integrity. It is composed of various polysaccharides, proteins, and other molecules, and is essential for the survival and function of these types of cells. In some cases, the cell wall may also play a role in cell division and communication with other cells.

Propyl gallate is a food additive and preservative that is commonly used to prevent the oxidation of fats and oils in food products. It is also used in cosmetics and pharmaceuticals as a preservative and antioxidant. In the medical field, propyl gallate is not typically used as a treatment for any specific condition, but it may be used in some research studies as a tool to investigate the effects of antioxidants on various biological processes. It is important to note that propyl gallate is considered safe for consumption in small amounts, but larger doses may cause side effects such as nausea, vomiting, and diarrhea.

Bacteremia is a medical condition in which bacteria are present in the bloodstream. It is a serious condition that can lead to sepsis, a life-threatening condition that occurs when the body's response to an infection causes widespread inflammation and organ damage. Bacteremia can be caused by a variety of bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, and Escherichia coli. It can be diagnosed through blood cultures, which involve taking a sample of blood and growing the bacteria in a laboratory to confirm the presence of the bacteria. Treatment for bacteremia typically involves antibiotics to kill the bacteria and manage the symptoms of the infection.

Beta-lactam resistance refers to the ability of bacteria to resist the effects of beta-lactam antibiotics, a class of antibiotics that includes penicillins, cephalosporins, and monobactams. This resistance can occur through various mechanisms, such as the production of beta-lactamase enzymes that break down the antibiotic, the alteration of the target site of the antibiotic, or the reduced permeability of the bacterial cell wall to the antibiotic. Beta-lactam resistance is a major concern in the medical field because it can lead to treatment failure and the spread of antibiotic-resistant infections.

Acetamides are a class of organic compounds that contain a carbonyl group (C=O) bonded to an amide group (-CONH2). They are commonly used as drugs and as intermediates in the synthesis of other drugs. In the medical field, acetamides are used as analgesics, antipyretics, and anti-inflammatory agents. One example of an acetamide drug is acetaminophen (also known as paracetamol), which is used to relieve pain and reduce fever. Other examples of acetamide drugs include amantadine, which is used to treat Parkinson's disease and influenza, and acetazolamide, which is used to treat glaucoma and altitude sickness. Acetamides can also be used as intermediates in the synthesis of other drugs. For example, they can be converted into amides, which are important components of many drugs, including antibiotics, antidepressants, and anticonvulsants.

Oxazolidinones are a class of synthetic antibiotics that are used to treat bacterial infections. They are a type of antibiotic called a "linezolid" and are often used to treat infections caused by Gram-positive bacteria, such as Staphylococcus aureus and Streptococcus pneumoniae. Oxazolidinones work by inhibiting the growth of bacteria by interfering with the production of proteins that are essential for bacterial cell growth and reproduction. They are typically administered orally or intravenously and are generally well-tolerated by patients. However, like all antibiotics, they can cause side effects, such as nausea, vomiting, and diarrhea.

Bacteriological techniques refer to the methods and procedures used to study and manipulate bacteria in the medical field. These techniques are used to identify, isolate, and culture bacteria, as well as to study their characteristics, behavior, and interactions with other microorganisms and the environment. Some common bacteriological techniques used in the medical field include: 1. Culture and isolation: This involves growing bacteria in a controlled environment, such as a petri dish or broth, to study their growth and behavior. 2. Identification: This involves using various methods, such as Gram staining, biochemical tests, and molecular techniques, to identify specific bacterial species. 3. Antibiotic susceptibility testing: This involves testing bacteria to determine their sensitivity to different antibiotics, which can help guide the selection of appropriate antibiotics for treatment. 4. Molecular techniques: These include techniques such as polymerase chain reaction (PCR) and DNA sequencing, which are used to study bacterial genetics and identify specific bacterial strains. 5. Immunological techniques: These include techniques such as enzyme-linked immunosorbent assay (ELISA) and immunofluorescence, which are used to detect and quantify specific bacterial antigens or antibodies in biological samples. Overall, bacteriological techniques play a critical role in the diagnosis, treatment, and prevention of bacterial infections and diseases in the medical field.

Cefazolin is an antibiotic medication that is used to treat a variety of bacterial infections, including skin infections, respiratory infections, urinary tract infections, and infections of the bones and joints. It is a cephalosporin antibiotic, which means that it works by stopping the growth of bacteria. Cefazolin is usually given intravenously (into a vein) or intramuscularly (into a muscle) and is typically used in hospital settings. It is important to note that cefazolin may not be effective against all types of bacteria, and it is important to use the medication as directed by a healthcare provider.

Sodium chloride, also known as table salt, is a chemical compound composed of sodium and chlorine ions. It is a white, odorless, and crystalline solid that is commonly used as a seasoning and preservative in food. In the medical field, sodium chloride is used as a medication to treat a variety of conditions, including dehydration, electrolyte imbalances, and certain types of heart failure. It is also used as a contrast agent in diagnostic imaging procedures such as X-rays and CT scans. Sodium chloride is available in various forms, including oral solutions, intravenous solutions, and topical ointments. It is important to note that excessive consumption of sodium chloride can lead to high blood pressure and other health problems, so it is important to use it only as directed by a healthcare professional.

Staphylococcal skin infections are a type of bacterial infection caused by the Staphylococcus aureus bacteria. These infections can occur on any part of the body, but are most common on the skin, particularly in areas that are warm and moist, such as the armpits, groin, and around the mouth. Staphylococcal skin infections can range from mild to severe, and can include conditions such as impetigo, folliculitis, and cellulitis. Symptoms of staphylococcal skin infections may include redness, swelling, pain, and pus-filled blisters or boils. In some cases, the infection may spread to other parts of the body, such as the bloodstream, bones, or joints, which can lead to more serious complications. Treatment for staphylococcal skin infections typically involves the use of antibiotics to kill the bacteria. In some cases, hospitalization may be necessary for more severe infections. It is important to seek medical attention if you suspect that you have a staphylococcal skin infection, as prompt treatment can help prevent complications and promote healing.

Fusidic acid is an antibiotic medication used to treat skin infections caused by certain types of bacteria, including staphylococci and streptococci. It works by stopping the growth of these bacteria, allowing the body's immune system to fight off the infection. Fusidic acid is available in various forms, including creams, ointments, and gels, and is typically applied directly to the affected area of the skin. It is usually used for short-term treatment, usually for up to 10 days, and is not effective against all types of bacteria. Common side effects of fusidic acid include skin irritation, redness, and itching at the application site. More serious side effects are rare, but may include allergic reactions, such as hives or difficulty breathing. Fusidic acid should not be used to treat viral infections, such as colds or flu, as it is only effective against bacterial infections. It is also important to follow the instructions for use carefully and to complete the full course of treatment, even if symptoms improve before the medication is finished.

Cefamandole is an antibiotic medication that belongs to the cephalosporin class of drugs. It is used to treat a variety of bacterial infections, including pneumonia, urinary tract infections, skin infections, and infections of the bones and joints. Cefamandole is typically administered intravenously, although it can also be given orally in some cases. It works by inhibiting the growth of bacteria by interfering with their ability to make cell walls. Like other cephalosporins, cefamandole is effective against a wide range of Gram-negative and Gram-positive bacteria, including many that are resistant to other antibiotics. However, it is important to note that cefamandole can also cause side effects, such as nausea, vomiting, diarrhea, and allergic reactions, and it may not be suitable for everyone.

Anti-infective agents, also known as antimicrobial agents, are drugs that are used to treat infections caused by microorganisms such as bacteria, viruses, fungi, and parasites. These agents work by either killing the microorganisms or inhibiting their growth and reproduction. There are several types of anti-infective agents, including antibiotics, antiviral drugs, antifungal drugs, and antiparasitic drugs. Antibiotics are the most commonly used anti-infective agents and are used to treat bacterial infections. Antiviral drugs are used to treat viral infections, while antifungal drugs are used to treat fungal infections. Antiparasitic drugs are used to treat parasitic infections. The use of anti-infective agents is an important part of modern medicine, as they are essential for treating a wide range of infections and preventing the spread of infectious diseases. However, the overuse and misuse of these agents can lead to the development of antibiotic-resistant bacteria, which can be difficult to treat and can pose a serious threat to public health.

Virginiamycin is a type of antibiotic that is used in the medical field to treat bacterial infections. It is a member of the class of antibiotics known as aminoglycosides, which work by binding to bacterial ribosomes and inhibiting protein synthesis. Virginiamycin is primarily used to treat infections in livestock, such as cattle and poultry, but it has also been used in humans in some cases. It is available in both oral and injectable forms and is typically used to treat infections of the respiratory tract, skin, and gastrointestinal tract.

Amikacin is an aminoglycoside antibiotic that is used to treat a variety of bacterial infections, including pneumonia, meningitis, and urinary tract infections. It works by binding to the ribosomes of bacteria, which are responsible for protein synthesis, and inhibiting their ability to produce essential proteins. This leads to bacterial cell death and the resolution of the infection. Amikacin is typically administered intravenously, although it can also be given intramuscularly or inhaled. It is important to note that amikacin can cause serious side effects, including hearing loss, kidney damage, and allergic reactions. Therefore, it is typically reserved for use in cases where other antibiotics have failed or are not effective, and it is closely monitored by healthcare providers to minimize the risk of adverse effects.

Moxalactam is an antibiotic medication that is used to treat certain types of bacterial infections. It is a member of a class of antibiotics called the beta-lactam antibiotics, which work by inhibiting the production of bacterial cell walls, leading to bacterial cell death. Moxalactam is typically used to treat infections of the respiratory tract, urinary tract, and skin and soft tissues. It is usually administered intravenously, although it is also available in an oral form. Moxalactam is not effective against all types of bacteria, and it may not be appropriate for everyone. It is important to discuss the potential benefits and risks of moxalactam with a healthcare provider before starting treatment.

DNA, Bacterial refers to the genetic material of bacteria, which is a type of single-celled microorganism that can be found in various environments, including soil, water, and the human body. Bacterial DNA is typically circular in shape and contains genes that encode for the proteins necessary for the bacteria to survive and reproduce. In the medical field, bacterial DNA is often studied as a means of identifying and diagnosing bacterial infections. Bacterial DNA can be extracted from samples such as blood, urine, or sputum and analyzed using techniques such as polymerase chain reaction (PCR) or DNA sequencing. This information can be used to identify the specific type of bacteria causing an infection and to determine the most effective treatment. Bacterial DNA can also be used in research to study the evolution and diversity of bacteria, as well as their interactions with other organisms and the environment. Additionally, bacterial DNA can be modified or manipulated to create genetically engineered bacteria with specific properties, such as the ability to produce certain drugs or to degrade pollutants.

Bacteriolysis is the process by which bacteria are destroyed or lysed, typically by the action of enzymes produced by other bacteria or by the host immune system. This process is an important mechanism for controlling bacterial infections in the body. Bacteriolysis can occur through a variety of mechanisms, including the production of enzymes that degrade the bacterial cell wall, the production of toxins that damage the bacterial cell membrane, or the activation of the host immune system to attack and destroy the bacteria. Bacteriolysis can be induced by a variety of factors, including antibiotics, antiseptics, and other antimicrobial agents. It can also be induced by the host immune system in response to an infection. In the medical field, bacteriolysis is an important tool for treating bacterial infections. Antibiotics and other antimicrobial agents can be used to induce bacteriolysis and help eliminate the bacteria from the body. In some cases, bacteriolysis may also be induced by the host immune system as part of the body's natural defense against infection.

Glycopeptides are a class of biomolecules that consist of a peptide chain covalently linked to one or more carbohydrate molecules, also known as glycans. In the medical field, glycopeptides are often used as antibiotics to treat bacterial infections. They work by inhibiting the synthesis of bacterial cell walls, leading to cell lysis and death. Examples of glycopeptide antibiotics include vancomycin, teicoplanin, and dalbavancin. These antibiotics are often used to treat severe and resistant bacterial infections, such as those caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).

Biofilms are complex communities of microorganisms that adhere to surfaces and are embedded in a self-produced extracellular matrix. In the medical field, biofilms are often associated with chronic infections that are difficult to treat with antibiotics. Biofilms can form on medical devices such as catheters, prosthetic joints, and dental implants, as well as on the surfaces of the human body. The bacteria in a biofilm are more resistant to antibiotics and the immune system than bacteria in a planktonic state, making them a significant challenge in the treatment of infections.

Rifampin is an antibiotic medication that is used to treat a variety of bacterial infections, including tuberculosis, meningitis, and pneumonia. It is a member of the rifamycin family of antibiotics and works by inhibiting the growth of bacteria by interfering with their ability to produce proteins. Rifampin is typically taken orally in the form of tablets or capsules and is often used in combination with other antibiotics to increase its effectiveness. It is important to take rifampin exactly as prescribed by a healthcare provider and to complete the full course of treatment, even if symptoms improve before the medication is finished.

Clavulanic acid is a type of beta-lactamase inhibitor that is used in combination with certain antibiotics to enhance their effectiveness against bacterial infections. Beta-lactamases are enzymes produced by some bacteria that can inactivate beta-lactam antibiotics, such as penicillins and cephalosporins, rendering them ineffective. Clavulanic acid works by binding to beta-lactamases and blocking their activity, allowing the beta-lactam antibiotics to remain active and effective against the bacteria. It is often used in combination with antibiotics such as amoxicillin-clavulanate, ticarcillin-clavulanate, and piperacillin-tazobactam to treat a variety of bacterial infections, including respiratory tract infections, skin infections, and urinary tract infections. Clavulanic acid is available as a prescription medication and is typically taken orally in tablet or capsule form. It is generally well-tolerated, but like all medications, it can cause side effects such as nausea, diarrhea, and allergic reactions.

Clindamycin is an antibiotic medication that is used to treat a variety of bacterial infections. It is a lincosamide antibiotic that works by stopping the growth of bacteria. Clindamycin is often used to treat infections of the skin, respiratory tract, and reproductive system, as well as certain types of bacterial infections that are resistant to other antibiotics. It is usually taken by mouth or given by injection, depending on the type and severity of the infection being treated. Clindamycin can cause side effects such as nausea, diarrhea, and stomach pain, and it may interact with other medications, so it is important to follow your healthcare provider's instructions carefully when taking this medication.

In the medical field, carrier proteins are proteins that transport molecules across cell membranes or within cells. These proteins bind to specific molecules, such as hormones, nutrients, or waste products, and facilitate their movement across the membrane or within the cell. Carrier proteins play a crucial role in maintaining the proper balance of molecules within cells and between cells. They are involved in a wide range of physiological processes, including nutrient absorption, hormone regulation, and waste elimination. There are several types of carrier proteins, including facilitated diffusion carriers, active transport carriers, and ion channels. Each type of carrier protein has a specific function and mechanism of action. Understanding the role of carrier proteins in the body is important for diagnosing and treating various medical conditions, such as genetic disorders, metabolic disorders, and neurological disorders.

Erythromycin is a broad-spectrum antibiotic that is commonly used to treat a variety of bacterial infections, including respiratory tract infections, skin infections, and sexually transmitted infections. It works by inhibiting the growth of bacteria by interfering with their ability to make proteins, which are essential for their survival. Erythromycin is available in various forms, including tablets, capsules, and liquid suspensions. It is usually taken orally, although it can also be given intravenously in severe cases. It is important to note that erythromycin may not be effective against all types of bacteria, and it can also cause side effects such as nausea, diarrhea, and allergic reactions. Therefore, it is important to use erythromycin only as directed by a healthcare professional and to complete the full course of treatment, even if symptoms improve before the medication is finished.

Peptidoglycan is a complex carbohydrate and protein molecule that forms the cell wall of most bacteria. It is composed of alternating units of sugars (N-acetylglucosamine and N-acetylmuramic acid) and peptides (short chains of amino acids) that are cross-linked together to form a strong, rigid structure. The peptidoglycan layer provides bacteria with structural support and protection against external stresses such as osmotic pressure and mechanical forces. It is also an important target for antibiotics, as many antibiotics work by disrupting the synthesis or integrity of the peptidoglycan layer, leading to bacterial cell lysis and death.

Novobiocin is an antibiotic that is used to treat certain bacterial infections. It is a bacteriostatic agent, which means that it stops the growth of bacteria without necessarily killing them. Novobiocin is most commonly used to treat infections caused by the bacteria Staphylococcus aureus and Streptococcus pyogenes. It is usually given orally or intravenously, and it can be used to treat both acute and chronic infections. Novobiocin is not effective against all types of bacteria, and it can cause side effects such as nausea, vomiting, and diarrhea. It is important to follow the instructions of a healthcare provider when taking novobiocin, as the dosage and duration of treatment will depend on the specific infection being treated.

A wound infection is an infection that occurs in a cut, scrape, or surgical incision. It can be caused by bacteria, viruses, fungi, or other microorganisms that enter the body through the wound. Symptoms of a wound infection may include redness, swelling, warmth, pain, pus, and a foul odor. If left untreated, a wound infection can lead to serious complications, such as sepsis, which is a life-threatening condition that can cause organ failure and even death. Treatment for a wound infection typically involves antibiotics, wound cleaning and dressing changes, and in some cases, surgery. It is important to seek medical attention if you suspect you have a wound infection to prevent further complications.

Imipenem is a broad-spectrum antibiotic that is used to treat a variety of bacterial infections. It is a member of the carbapenem class of antibiotics, which are known for their effectiveness against multidrug-resistant bacteria. Imipenem is typically administered intravenously and is used to treat infections of the respiratory tract, urinary tract, skin and soft tissues, and the bloodstream. It is also sometimes used to treat infections of the abdomen, including those caused by bacteria that are resistant to other antibiotics. Imipenem works by inhibiting the production of bacterial cell walls, which leads to the death of the bacteria. It is a broad-spectrum antibiotic, meaning that it is effective against a wide range of bacteria, including both gram-positive and gram-negative bacteria. However, like all antibiotics, imipenem can cause side effects, including nausea, vomiting, diarrhea, and allergic reactions. It is important to take imipenem exactly as prescribed by a healthcare provider and to notify them if any side effects occur.

Tetracycline is a broad-spectrum antibiotic that is commonly used to treat a variety of bacterial infections, including respiratory tract infections, urinary tract infections, skin infections, and sexually transmitted infections. It works by inhibiting the growth of bacteria by blocking the synthesis of proteins that are essential for bacterial growth and reproduction. Tetracycline is available in various forms, including tablets, capsules, and liquid solutions. It is usually taken orally, although it can also be given intravenously in severe cases. Tetracycline is generally well-tolerated, but it can cause side effects such as nausea, vomiting, diarrhea, and stomach pain. It can also cause tooth discoloration and interfere with the development of bones in children. Tetracycline is not recommended for use in pregnant women or children under the age of eight, as it can cause permanent discoloration of the teeth and interfere with bone development. It is also not recommended for use in people with certain medical conditions, such as liver or kidney disease, or in those who are allergic to tetracycline or other antibiotics.

In the medical field, "Colony Count, Microbial" refers to the process of counting the number of colonies of microorganisms that have grown on a culture plate. This is a common laboratory technique used to determine the concentration or density of microorganisms in a sample. To perform a colony count, a sample is typically taken from a patient or an environmental source and then cultured on a nutrient-rich agar plate. The plate is incubated for a specific period of time to allow the microorganisms to grow and form colonies. The colonies are then counted and the results are expressed in colony-forming units (CFUs) per milliliter or per gram of the original sample. The colony count can be used to diagnose infections caused by microorganisms, to monitor the effectiveness of antimicrobial treatments, and to assess the quality of food and water. It is an important tool in the field of microbiology and is used in a variety of settings, including hospitals, laboratories, and research facilities.

Micrococcal nuclease (MNase) is a type of enzyme that is commonly used in molecular biology research to study the structure and function of DNA. It is derived from the bacterium Staphylococcus aureus and is a member of the DNase family of enzymes. MNase is a highly specific enzyme that cleaves DNA at the phosphodiester bond between the phosphate group and the sugar-phosphate backbone, leaving a 3' hydroxyl group and a 5' phosphate group. This enzyme is particularly useful for studying the structure of DNA, as it can be used to generate single-stranded DNA fragments that can be analyzed using a variety of molecular biology techniques. In the medical field, MNase is used in a variety of applications, including the study of chromatin structure, the analysis of DNA-protein interactions, and the development of new DNA-based therapies. It is also used in diagnostic tests to detect and identify bacterial infections, as well as in the treatment of certain types of cancer.

Bacterial typing techniques are methods used to identify and classify bacteria based on their characteristics, such as their shape, size, and genetic makeup. These techniques are important in the medical field because they help healthcare professionals to identify the specific type of bacteria causing an infection and to determine the most effective treatment for that infection. There are several different bacterial typing techniques, including: 1. Serotyping: This technique involves identifying the specific proteins on the surface of bacteria, called antigens, which can be used to distinguish one strain of bacteria from another. 2. Pulsed-field gel electrophoresis (PFGE): This technique involves separating bacterial DNA into fragments of different sizes using an electric field, and then comparing the patterns of these fragments to determine the genetic relatedness of different strains of bacteria. 3. Multilocus sequence typing (MLST): This technique involves sequencing specific regions of bacterial DNA and comparing the sequences to determine the genetic relatedness of different strains of bacteria. 4. Antibiotic susceptibility testing: This technique involves testing bacteria to determine their sensitivity to different antibiotics, which can help healthcare professionals to choose the most effective treatment for a particular infection. Overall, bacterial typing techniques are important tools in the diagnosis and treatment of bacterial infections, and they play a critical role in the development of new antibiotics and other treatments for bacterial diseases.

Osteomyelitis is a type of bone infection that occurs when bacteria enter the bone and cause inflammation and damage to the bone tissue. It can affect any bone in the body, but it is most commonly seen in the long bones of the arms and legs, as well as in the spine and pelvis. Osteomyelitis can be acute or chronic, and it can be caused by a variety of factors, including bacterial infections, fungal infections, and viral infections. It can also be caused by traumatic injuries, such as fractures or punctures, or by medical procedures, such as surgery or the insertion of a catheter. Symptoms of osteomyelitis may include fever, chills, fatigue, and pain in the affected bone. In some cases, there may be no symptoms at all until the infection has progressed significantly. Treatment for osteomyelitis typically involves antibiotics to kill the bacteria causing the infection. In some cases, surgery may be necessary to remove infected tissue or to drain abscesses. Physical therapy may also be recommended to help restore strength and mobility to the affected bone.

Ciprofloxacin is an antibiotic medication that is used to treat a variety of bacterial infections, including urinary tract infections, respiratory infections, skin infections, and gastrointestinal infections. It is a fluoroquinolone antibiotic that works by inhibiting the growth and reproduction of bacteria. Ciprofloxacin is available in oral and intravenous forms, and it is typically prescribed for a specific duration of time, depending on the type and severity of the infection. It is important to take the medication exactly as prescribed by a healthcare provider, as stopping the medication too early can lead to the development of antibiotic-resistant bacteria. Common side effects of ciprofloxacin include nausea, diarrhea, headache, dizziness, and skin rash. In rare cases, it can cause more serious side effects, such as tendonitis or tendon rupture, and central nervous system problems. It is important to inform a healthcare provider of any other medications or medical conditions that may interact with ciprofloxacin.

Cefotaxime is an antibiotic medication that is used to treat a variety of bacterial infections, including pneumonia, meningitis, urinary tract infections, and gonorrhea. It is a cephalosporin antibiotic, which means that it works by stopping the growth of bacteria. Cefotaxime is typically administered intravenously, although it may also be available as an oral medication. It is important to note that cefotaxime is only effective against bacterial infections and will not work against viral infections. It is also important to follow the dosing instructions provided by your healthcare provider and to complete the full course of treatment, even if you start to feel better before the medication is finished.

Gram-positive bacterial infections are infections caused by bacteria that stain positively with the Gram stain, a common laboratory test used to differentiate between different types of bacteria. Gram-positive bacteria have a thick peptidoglycan layer in their cell walls, which stains pink or purple with the Gram stain. Gram-positive bacterial infections can affect various parts of the body, including the skin, respiratory system, urinary tract, and bloodstream. Some common examples of gram-positive bacterial infections include strep throat, pneumonia, cellulitis, and endocarditis. Treatment for gram-positive bacterial infections typically involves the use of antibiotics, which are medications that can kill or inhibit the growth of bacteria. The choice of antibiotic will depend on the specific type of bacteria causing the infection and the severity of the infection. In some cases, hospitalization may be necessary for more severe infections.

Bacterial load refers to the number of bacteria present in a particular sample or tissue. It is commonly used in the medical field to assess the severity of bacterial infections and to monitor the effectiveness of antibiotic treatments. Bacterial load can be measured using various techniques, including culture-based methods, molecular techniques such as polymerase chain reaction (PCR), and imaging techniques such as computed tomography (CT) scans or magnetic resonance imaging (MRI). A high bacterial load is typically associated with more severe infections and a greater risk of complications, while a low bacterial load may indicate a milder infection or successful treatment with antibiotics. However, the interpretation of bacterial load can be complex and may depend on the specific type of bacteria, the location of the infection, and other factors.

In the medical field, "Brazil" typically refers to the country located in South America. Brazil is the largest country in both South America and Latin America, and it is known for its diverse population, rich culture, and natural resources. In terms of healthcare, Brazil has a publicly funded healthcare system called the Unified Health System (Sistema Único de Saúde, or SUS). The SUS provides free or low-cost healthcare services to all Brazilian citizens and residents, including primary care, hospitalization, and specialized medical care. Brazil has also made significant strides in public health, particularly in the areas of infectious diseases such as HIV/AIDS, tuberculosis, and dengue fever. The country has implemented widespread vaccination programs and has made efforts to improve access to healthcare services in underserved areas. However, Brazil still faces significant challenges in the healthcare sector, including a shortage of healthcare professionals, inadequate infrastructure, and disparities in access to healthcare services between different regions and socioeconomic groups.

In the medical field, a carrier state refers to a person who carries a specific infectious agent or genetic abnormality without showing any signs or symptoms of the disease or condition caused by it. For example, a person who carries the human immunodeficiency virus (HIV) but does not have symptoms of acquired immune deficiency syndrome (AIDS) is considered an HIV carrier. Similarly, a person who carries a gene mutation that increases their risk of developing a certain genetic disorder, such as cystic fibrosis, but does not show any symptoms of the disorder is also considered a carrier. Carriers can still transmit the infectious agent or genetic abnormality to others, even if they themselves are not affected by the disease or condition. This is why it is important to identify and manage carrier states in order to prevent the spread of infectious diseases and genetic disorders.

In the medical field, blood refers to the liquid component of the circulatory system that carries oxygen, nutrients, hormones, and waste products throughout the body. It is composed of red blood cells, white blood cells, platelets, and plasma. Red blood cells, also known as erythrocytes, are responsible for carrying oxygen from the lungs to the body's tissues and carbon dioxide from the tissues to the lungs. White blood cells, also known as leukocytes, are part of the immune system and help protect the body against infections and diseases. Platelets, also known as thrombocytes, are involved in blood clotting and help prevent excessive bleeding. Plasma is the liquid portion of blood that contains water, proteins, electrolytes, and other substances. Blood is collected through a process called phlebotomy, which involves drawing blood from a vein using a needle. Blood can be used for a variety of medical tests and procedures, including blood typing, blood transfusions, and the diagnosis of various medical conditions.

Community-acquired infections (CAIs) are infections that are acquired by an individual in the community, rather than in a healthcare setting. These infections can be caused by a variety of microorganisms, including bacteria, viruses, fungi, and parasites. CAIs can be transmitted through various means, such as person-to-person contact, contaminated food or water, or contact with contaminated surfaces. Examples of CAIs include the common cold, influenza, pneumonia, urinary tract infections, and skin infections. These infections can be treated with antibiotics, antiviral medications, or antifungal medications, depending on the specific cause of the infection. It is important to note that CAIs can be serious and can lead to hospitalization or even death, particularly in vulnerable populations such as the elderly, young children, and people with weakened immune systems.

Pneumococcal infections are a group of illnesses caused by the bacterium Streptococcus pneumoniae. These infections can affect various parts of the body, including the lungs, sinuses, ears, bloodstream, and brain. The most common type of pneumococcal infection is pneumonia, which is an inflammation of the lungs caused by bacteria. Other types of pneumococcal infections include meningitis (inflammation of the lining of the brain and spinal cord), otitis media (middle ear infection), sinusitis (sinus infection), and bacteremia (presence of bacteria in the bloodstream). Pneumococcal infections can be serious, especially in people with weakened immune systems, such as young children, older adults, and people with chronic medical conditions. Vaccines are available to prevent some types of pneumococcal infections, and antibiotics are used to treat them.

Bacteria are single-celled microorganisms that are found in almost every environment on Earth, including soil, water, and the human body. In the medical field, bacteria are often studied and classified based on their characteristics, such as their shape, size, and genetic makeup. Bacteria can be either beneficial or harmful to humans. Some bacteria are essential for human health, such as the bacteria that live in the gut and help digest food. However, other bacteria can cause infections and diseases, such as strep throat, pneumonia, and meningitis. In the medical field, bacteria are often identified and treated using a variety of methods, including culturing and identifying bacteria using specialized laboratory techniques, administering antibiotics to kill harmful bacteria, and using vaccines to prevent bacterial infections.

Sepsis is a serious medical condition that occurs when the body's response to an infection causes widespread inflammation throughout the body. It is a life-threatening condition that can lead to organ failure, septic shock, and even death if not treated promptly and effectively. Sepsis can develop from any type of infection, including bacterial, viral, fungal, or parasitic infections. The body's immune system responds to the infection by releasing chemicals called cytokines, which can cause inflammation throughout the body. This inflammation can damage tissues and organs, leading to a range of symptoms, including fever, chills, rapid heartbeat, rapid breathing, confusion, and decreased urine output. Diagnosis of sepsis typically involves a combination of clinical examination, laboratory tests, and imaging studies. Treatment typically involves antibiotics to treat the underlying infection, as well as supportive care to manage symptoms and prevent complications. In severe cases, treatment may include fluid resuscitation, vasopressors to maintain blood pressure, and organ support. Early recognition and prompt treatment of sepsis are critical for improving outcomes and reducing the risk of death.

Bacterial infections are caused by bacteria, which are single-celled microorganisms that can be found almost everywhere in the environment, including on our skin and in our digestive tracts. When bacteria enter the body and multiply, they can cause illness and disease. Bacterial infections can affect any part of the body and can range from mild to severe. Some common examples of bacterial infections include strep throat, urinary tract infections, pneumonia, meningitis, and skin infections. Bacterial infections can be treated with antibiotics, which are medications that kill or inhibit the growth of bacteria. However, it is important to use antibiotics properly and only when necessary, as overuse can lead to antibiotic resistance, which makes it more difficult to treat bacterial infections in the future.

Oxacillin is a type of antibiotic medication that is used to treat a variety of bacterial infections. It is a beta-lactam antibiotic, which means that it works by inhibiting the production of bacterial cell walls, leading to the death of the bacteria. Oxacillin is commonly used to treat skin infections, respiratory infections, urinary tract infections, and other types of bacterial infections. It is often prescribed for patients who are allergic to penicillin, as it is a close relative of penicillin and is less likely to cause an allergic reaction. It is important to note that oxacillin is only effective against bacterial infections and will not work against viral infections such as the common cold or flu. Additionally, it is important to take oxacillin exactly as prescribed by a healthcare provider to ensure that it is effective and to prevent the development of antibiotic resistance.

In the medical field, a base sequence refers to the specific order of nucleotides (adenine, thymine, cytosine, and guanine) that make up the genetic material (DNA or RNA) of an organism. The base sequence determines the genetic information encoded within the DNA molecule and ultimately determines the traits and characteristics of an individual. The base sequence can be analyzed using various techniques, such as DNA sequencing, to identify genetic variations or mutations that may be associated with certain diseases or conditions.

The substituent present on oxacillin is thought to impart resistance to degradation via bacterial β-lactamases. Oxacillin, a ... Oxacillin Sodium Capsule Applicant: Ani Pharms Inc May 15, 1980: Oxacillin Sodium for Solution Applicant: TEVA June 2, 1981: ... Oxacillin Sodium Injectable Applicant: Wockhardt Bio/Ag The average wholesale price (AWP) for oxacillin products are provided ... Oxacillin Sodium Injectable Applicant: Watson Labs Inc October 26, 1988: Oxacillin Sodium Injectable Applicant: Watson Labs Inc ...
At the University of Tennessee, 46.6% of the S. schleiferi isolated were resistant to oxacillin. Seven strains of methicillin- ... Jones RD, Kania SA, Rohrbach BW, Frank LA, Bemis DA (January 2007). "Prevalence of oxacillin- and multidrug-resistant ... February 2018). "mecA-Mediated Oxacillin Resistance in Staphylococcus schleiferi". Journal of Clinical Microbiology. 56 (2). ... characterization of Staphylococcus schleiferi infections and identification of risk factors for acquisition of oxacillin- ...
Dicloxacillin Flucloxacillin Nafcillin Oxacillin World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO ...
Therefore, treatment with nafcillin, oxacillin, or vancomycin is typically indicated. Clindamycin is sometimes also used ...
By 1962, a series of similarly structured acid-stable penicillins (oxacillin, cloxacillin, dicloxacillin and flucloxacillin), ... compared with oxacillin, cloxacillin, and dicloxacillin". British Medical Journal. 4 (5733): 455-60. doi:10.1136/bmj.4.5733.455 ... while Bristol Laboratories concentrated on marketing oxacillin and dicloxacillin in the United States, leading to the ...
... cefoxitin is more reliable than oxacillin because mecC does not correlate as strongly with oxacillin resistance. Cefoxitin's ... Staphylococci that are resistant to methicillin and oxacillin should also be considered clinically resistant to cefoxitin even ... cefoxitin is more reliable than oxacillin". The Journal of Antimicrobial Chemotherapy. 69 (1): 133-5. doi:10.1093/jac/dkt341. ...
Pereira VC, Cunha Mde L (November 2013). "Coagulase-negative staphylococci strains resistant to oxacillin isolated from ...
Naficillin, oxacillin, and dicloxacillin are also effective against infections of the lymphatic system.[citation needed] ...
Glew RH, Millering RS, Wennersten C (June 1975). "Comparative synergistic activity of nafcillin, oxacillin, and methicillin in ...
... a novel parenteral cephalosporin active against oxacillin-resistant staphylococci". The Journal of Antimicrobial Chemotherapy. ...
In addition, the 26 isolated strains of this new subspecies are resistant to nalidixic acid, penicillin G, oxacillin, kanamycin ... The combined resistance to novobiocin and oxacillin is hypothesized to have originated from a simultaneous introduction of ... "A sequence variant of Staphylococcus hominis with a high prevalence of oxacillin and fluoroquinolone resistance". Research in ...
Synergy or partial synergy has been demonstrated between rhein and the antibiotics oxacillin and ampicillin. Rhein has been ... 2012). "Synergistic effect of rhein in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus ...
PBP2a is a variant penicillin-binding protein that imparts the ability of S. aureus to be resistant to oxacillin. Like all S. ... penicillin derivatives such as methicillin and oxacillin) and cephems such as the cephalosporins. Strains unable to resist ... aureus have emerged that are resistant to oxacillin, clindamycin, teicoplanin, and erythromycin. These resistant strains may or ...
Oxacillin resistance decreased in S. aureus strains when expression of PBP4 was inhibited but PBP2a was not. mecA is acquired ... Anand KB, Agrawal P, Kumar S, Kapila K (2009). "Comparison of cefoxitin disc diffusion test, oxacillin screen agar, and PCR for ... to the point where oxacillin, which acts on PBP2 and PBP2a, effectively inhibits cell wall formation. Interactions with other ...
"In vitro antimicrobial activity of the aminoglycoside arbekacin tested against oxacillin-resistant Staphylococcus aureus ...
U.S. clinical practice guidelines recommend either nafcillin or oxacillin as the first-line treatment of choice for ... Nafcillin is considered therapeutically equivalent to oxacillin, although one retrospective study found greater rates of ... Events Lead to Drug Discontinuation More Commonly among Patients Who Receive Nafcillin than among Those Who Receive Oxacillin ... hypokalemia and acute kidney injury in patients taking nafcillin compared to patients taking oxacillin. Nafcillin is indicated ...
... typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: ...
Methicillin was then the antibiotic of choice, but has since been replaced by oxacillin because of significant kidney toxicity ...
Rosdahl VT, Frimodt-Møller N, Bentzon MW (August 1989). "Resistance to dicloxacillin, methicillin and oxacillin in methicillin- ...
The β-lactamase-resistant penicillins (methicillin, oxacillin, cloxacillin, and flucloxacillin) were developed to treat ... Penicillinase-resistant β-lactam antibiotics, such as methicillin, nafcillin, oxacillin, cloxacillin, dicloxacillin, and ... oxacillin or flucloxacillin, both of which have the same mechanism of action as penicillin) or vancomycin, depending on local ...
When ulcers develop secondary to the congenital disease, antibiotic treatment such as oxacillin and gentamicin administered for ...
Although cefoxitin disks have been used, oxacillin disks are considered to be much more sensitive, and thus a more accurate ... March 2016). "Evaluation of Oxacillin and Cefoxitin Disk and MIC Breakpoints for Prediction of Methicillin Resistance in Human ...
... usually oxacillin sodium or cephradine, and assert that surgery and drainage are unnecessary.: p. 609 Wilson-MacDonald argues ...
For example, amfetamine and oxacillin are INNs, whereas various salts of these compounds - e.g., amfetamine sulfate and ... oxacillin sodium - are modified INNs (INNM). Several countries had created their own nonproprietary naming system before the ...
Oxacillin (US) History of penicillin List of antibiotics Side effects of penicillin Alan R. Hauser (6 March 2012). Antibiotic ...
The class D β-lactamases (OXA), which hydrolyze oxacillin, provide a good example of the variety of mechanisms that can be used ...
Additional reports have found A. equuli resistance to oxacillin and trimethoprim-sulphadimidine along with developed resistance ...
RNA targeting mecA mRNA has been shown to restore the susceptibility of methicillin-resistant staphylococci to oxacillin in ...
... is resistant to penicillins (specifically benzylpenicillin, oxacillin), macrolides (with the exception ...
... were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and ... confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and ...
The substituent present on oxacillin is thought to impart resistance to degradation via bacterial β-lactamases. Oxacillin, a ... Oxacillin Sodium Capsule Applicant: Ani Pharms Inc May 15, 1980: Oxacillin Sodium for Solution Applicant: TEVA June 2, 1981: ... Oxacillin Sodium Injectable Applicant: Wockhardt Bio/Ag The average wholesale price (AWP) for oxacillin products are provided ... Oxacillin Sodium Injectable Applicant: Watson Labs Inc October 26, 1988: Oxacillin Sodium Injectable Applicant: Watson Labs Inc ...
Oxacillin Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Use oxacillin injection until you finish the prescription, even if you feel better. If you stop using oxacillin injection too ... Oxacillin injection is used to treat infections caused by certain bacteria. Oxacillin injection is in a class of medications ... Before receiving oxacillin injection,. *tell your doctor and pharmacist if you are allergic to oxacillin; penicillins; ...
Report as oxacillin susceptible. ** Report as oxacillin resistant. †There is no intermediate category with the cefoxitin disk ... Is it difficult to detect oxacillin/methicillin resistance? Accurate detection of oxacillin/methicillin resistance can be ... such as oxacillin and methicillin. Strains that are oxacillin and methicillin resistant, historically termed methicillin- ... Why are oxacillin and cefoxitin tested instead of methicillin? First, methicillin is no longer commercially available in the ...
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LBXMO2 - Oxacillin 2. Variable Name: LBXMO2. SAS Label: Oxacillin 2. English Text: Oxacillin 2 Target: Both males and females 1 ... LBXMO1 - Oxacillin 1. Variable Name: LBXMO1. SAS Label: Oxacillin 1. English Text: Oxacillin 1. Target: Both males and females ... Overnight cultures from BAP were plated on Mueller-Hinton (MH) agar, and a 1-μg oxacillin (OX) disk was placed on the ...
Oxacillin is a bactericidal antibiotic that inhibits cell-wall synthesis. It is used to treat infections caused by ... Oxacillin may be used to start therapy when a staphylococcal infection is suspected. ...
Oxacillin Sodium published on 01 Jan 2023 by ASHP. ... Oxacillin Sodium AHFS 8:12.16.12 in ASHP® Injectable Drug ...
2 Cefoxitin is tested as a surrogate for mecA-mediated oxacillin resistance. 6 Interpretation based on the individual drug MIC ...
Detailed drug Information for Ortho-Cyclen. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Zibo Shiji Zhonglian Pharmaceutical Technology Co., Ltd.--Ampicillin Sodium,Sulbactam Sodium,Piperacillin Sodium,oxacillin Sodium,Procaine Penicillin
Oxacillin Oxacillin is a penicillin antibiotic that treats bacterial infections. They are commonly used to treat various ... Oxacillin is commonly used for certain illnesses like meningitis, pneumonia, joint pain and skin or soft tissue infections. ...
Oxacillin. 7/17 (41). Clindamycin. 9/17 (52). Rifampin. 6/15 (40). ...
... treatment of Staphylococcus epidermidis prosthetic valve endocarditis with linezolid after failure of treatment with oxacillin ... treatment of Staphylococcus epidermidis prosthetic valve endocarditis with linezolid after failure of treatment with oxacillin ... treatment of Staphylococcus epidermidis prosthetic valve endocarditis with linezolid after failure of treatment with oxacillin ... treatment of Staphylococcus epidermidis prosthetic valve endocarditis with linezolid after failure of treatment with oxacillin ...
The N- and C-terminal domains of PrsA were found to be critical features for PBP2A protein membrane levels and oxacillin ... The N- and C-terminal domains of PrsA were found to be critical features for PBP2A protein membrane levels and oxacillin ... The N- and C-terminal domains of PrsA were found to be critical features for PBP2A protein membrane levels and oxacillin ... The N- and C-terminal domains of PrsA were found to be critical features for PBP2A protein membrane levels and oxacillin ...
A substantial increase in the frequency of oxacillin-resistance (methicillin-resistant) in CoNS isolates has occurred over the ... The isolates were tested for susceptibility to oxacillin, vancomycin and teicoplanin by the agar disk diffusion method with ... The objective of this study was to evaluate eleven consecutives clinically relevant cases of oxacillin-resistant CoNS ... The objective of this study was to evaluate eleven consecutives clinically relevant cases of oxacillin-resistant CoNS ...
Staphylococcus aureus with a result of resistant (R) to methicillin, oxacillin, or cefoxitin. ...
Oxacillin: (Minor) Sulfonamides may compete with oxacillin for renal tubular secretion, increasing oxacillin serum ...
Oxacillin, nafcillin, and cefazolin are preferred agents for treatment of proven MSSA, but are not necessary for the empiric ... When the pathogen is confirmed as MSSA, the patient should be switched to oxacillin, nafcillin, or cefazolin. ... In cases of proven MSSA infection, oxacillin, nafcillin, or cefazolin is favored. ...
oxacillin. Serious - Use Alternative (1)sarecycline decreases effects of oxacillin by pharmacodynamic antagonism. Avoid or Use ... oxacillin. sarecycline decreases effects of oxacillin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Tetracyclines ...
Oxacillin, which is in the same class as methicillin. These were of MRSA, methicillin-resistant Staph aureus, now killing more ... Oxacillin, which is in the same class as methicillin. These were of MRSA, methicillin-resistant Staph aureus, now killing more ...
Intravenous Suitability Studies of Commonly Used Oxacillin Sodium Solutions in the ACCUFUSER® Infusion Device (Articles) ...
Staphylococci which are resistant to methicillin/oxacillin must be considered resistant to amoxicillin/clavulanic acid. ...
Diagnostic Test Validity of Oxacillin Screen Agar for the Detection of Methicillin Resistant Staphylococcus aureus (Articles) ...
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Phenotypic and genomic characteristics of oxacillin-susceptible mecA-positive Staphylococcus aureus, rapid selection of high- ... AbstractThe aim of this study is to describe the phenotypic and genetic properties of oxacillin-susceptible methicillin- ... A collection of hospital- (HA-) and community-acquired (CA-) MRSA was screened for oxacillin susceptibility. Antibiotic ... isolates and their beta-lactam resistant derivatives obtained after selection with oxacillin. ...
  • By decreasing the integrity of the bacterial cell wall, it is thought that oxacillin and other penicillins kill actively growing bacteria through cell autolysis. (wikipedia.org)
  • While methicillin could only be administered via injection, the isoxazolyl penicillins, including oxacillin, could be given orally or by injection. (wikipedia.org)
  • Oxacillin injection is in a class of medications called penicillins. (medlineplus.gov)
  • However, many S. aureus strains, while resistant to penicillin, remain susceptible to penicillinase-stable penicillins, such as oxacillin and methicillin. (cdc.gov)
  • This phenomenon is termed heteroresistance and occurs in staphylococci resistant to penicillinase-stable penicillins, such as oxacillin. (cdc.gov)
  • However, with the introduction and widespread use of both oxacillin and methicillin, antibiotic-resistant strains called methicillin-resistant and oxacillin-resistant Staphylococcus aureus (MRSA/ORSA) have become increasingly prevalent worldwide. (wikipedia.org)
  • Members of the isoxazolyl penicillin family, which includes cloxacillin, dicloxacillin, and oxacillin, were synthesized to counter the increasing prevalence of infections caused by penicillin-resistant Staphylococcus aureus. (wikipedia.org)
  • Case Commentary: The hidden side of oxacillin resistance in Staphylococcus aureus . (bvsalud.org)
  • Cells expressing heteroresistance grow more slowly than the oxacillin-susceptible population and may be missed at temperatures above 35°C. This is why CLSI recommends incubating isolates being tested against oxacillin, methicillin, or nafcillin at 33-35° C (maximum of 35°C) for a full 24 hours before reading (1). (cdc.gov)
  • The substituent present on oxacillin is thought to impart resistance to degradation via bacterial β-lactamases. (wikipedia.org)
  • Is it difficult to detect oxacillin/methicillin resistance? (cdc.gov)
  • Accurate detection of oxacillin/methicillin resistance can be difficult due to the presence of two subpopulations (one susceptible and the other resistant) that may coexist within a culture of staphylococci (2). (cdc.gov)
  • Are there additional tests to detect oxacillin/methicillin resistance? (cdc.gov)
  • Nucleic acid amplification tests, such as the polymerase chain reaction (PCR), can be used to detect the mec A gene, which mediates oxacillin resistance in staphylococci. (cdc.gov)
  • Staphylococcal resistance to oxacillin/methicillin occurs when an isolate carries an altered penicillin-binding protein, PBP2a, which is encoded by the mec A gene. (cdc.gov)
  • Deletion of prsA altered oxacillin resistance in three different SCCmec backgrounds and, more importantly, caused a decrease in PBP2A membrane amounts without affecting mecA mRNA levels. (unl.pt)
  • The N- and C-terminal domains of PrsA were found to be critical features for PBP2A protein membrane levels and oxacillin resistance. (unl.pt)
  • Overnight cultures from BAP were plated on Mueller-Hinton (MH) agar, and a 1-μg oxacillin (OX) disk was placed on the inoculated plate. (cdc.gov)
  • Bactocill in Dextrose Intravenous 1 g/50 mL: $20.37 2 g/50 mL: $32.48 Oxacillin Sodium Injection 1 g: $17.52 2 g: $33.99 10 g: $138.77 ChemBank Greenwood D (2008). (wikipedia.org)
  • Oxacillin sodium for injection for intramuscular or intravenous injection prescribing information. (wikipedia.org)
  • Strains that are oxacillin and methicillin resistant, historically termed methicillin-resistant S. aureus (MRSA), are resistant to all ß-lactam agents, including cephalosporins and carbapenems. (cdc.gov)
  • James Hadler] Well, MRSA developed from methicillin-susceptible staph because methicillin and its relatives, such as oxacillin, were widely used and selected for resistant strains. (cdc.gov)
  • After adjustment for oxacillin and clindamycin susceptibility in analysis, multidrug-resistant S. aureus was observed to have low odds of being czrC positive (P = .03). (cdc.gov)
  • Oxacillin is useful against methicillin-sensitive S aureus (MSSA). (medscape.com)
  • citation needed] The use of oxacillin is contraindicated in individuals that have experienced a hypersensitivity reaction to any medication in the penicillin family of antibiotics. (wikipedia.org)
  • Antibiotics such as oxacillin injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
  • If you stop using oxacillin injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • The objective of this study was to evaluate eleven consecutives clinically relevant cases of oxacillin-resistant CoNS bacteremia in a general hospital localized in São Paulo city, Brazil. (scielo.br)
  • Of the study participants, 245 linezolid-treated patients and 242 oxacillin-treated patients were clinically evaluable. (renalandurologynews.com)
  • When oxacillin disk screening is the only antimicrobial susceptibility method used, the antimicrobial susceptibility profile cannot be definitely determined. (cdc.gov)
  • A probable case of invasive DRSP is defined as either meningitis or bacteremia in which S. pneumoniae cultured from CSF or blood is identified as nonsusceptible by oxacillin screening (i.e., zone size less than or equal to 19 mm) and no further antimicrobial susceptibility testing has been performed. (cdc.gov)
  • Oxacillin may be used to start therapy when a staphylococcal infection is suspected. (medscape.com)
  • As an injection, oxacillin may cause injection site reactions, which may be characterized by redness, swelling, and itching. (wikipedia.org)
  • The cure rates were 90% for linezolid-treated patients and 85% for oxacillin-treated patients. (renalandurologynews.com)
  • The cure rates in the MITT analysis were 86% in linezolid-treated patients and 82% in oxacillin-treated patients. (renalandurologynews.com)
  • Oxacillin injection is used to treat infections caused by certain bacteria. (medlineplus.gov)
  • Oxacillin (trade name Bactocill) is a narrow-spectrum beta-lactam antibiotic of the penicillin class developed by Beecham. (wikipedia.org)
  • Oxacillin is a bactericidal antibiotic that inhibits cell-wall synthesis. (medscape.com)
  • High doses of oxacillin have been reported to cause renal, hepatic, and nervous system toxicity. (wikipedia.org)
  • Oxacillin is a penicillinase-resistant β-lactam. (wikipedia.org)
  • Oxacillin, through its β-lactam ring, covalently binds to penicillin-binding proteins, which are enzymes involved in the synthesis of the bacterial cell wall. (wikipedia.org)
  • Following the synthesis of cloxacillin and oxacillin, Beecham retained the right to commercially develop cloxacillin in the United Kingdom while Bristol-Myers was given the marketing rights for oxacillin in the United States. (wikipedia.org)
  • Common to all members of the penicillin class of drugs, oxacillin may cause acute or delayed hypersensitivity reactions. (wikipedia.org)
  • You should begin to feel better during the first few days of treatment with oxacillin injection. (medlineplus.gov)
  • As with other members of the penicillin family, the chemical structure of oxacillin features a 6-aminopenicillanic acid nucleus with a substituent attached to the amino group. (wikipedia.org)
  • You may receive oxacillin injection in a hospital or you may administer the medication at home. (medlineplus.gov)
  • To obtain data from laboratories that perform only oxacillin screening, a probable case definition has been made. (cdc.gov)