A mature haploid female germ cell extruded from the OVARY at OVULATION.
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
Transport of the OVUM or fertilized ovum (ZYGOTE) from the mammalian oviduct (FALLOPIAN TUBES) to the site of EMBRYO IMPLANTATION in the UTERUS.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
Substances that are recognized by the immune system and induce an immune reaction.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.
Occurrence or induction of release of more ova than are normally released at the same time in a given species. The term applies to both animals and humans.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
The discharge of an OVUM from a rupturing follicle in the OVARY.
The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989)
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A pair of highly specialized muscular canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM collection, and the site for the final maturation of gametes and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three histologic layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.
The fusion of a spermatozoon (SPERMATOZOA) with an OVUM thus resulting in the formation of a ZYGOTE.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Class I-restricted activation of CD8-POSITIVE LYMPHOCYTES resulting from ANTIGEN PRESENTATION of exogenous ANTIGENS (cross-presentation). This is in contrast to normal activation of these lymphocytes (direct-priming) which results from presentation of endogenous antigens.
Abnormal increase of EOSINOPHILS in the blood, tissues or organs.
Aluminum metal sulfate compounds used medically as astringents and for many industrial purposes. They are used in veterinary medicine for the treatment of ulcerative stomatitis, leukorrhea, conjunctivitis, pharyngitis, metritis, and minor wounds.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
Delivery of medications through the nasal mucosa.
Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.
A glandular epithelial cell or a unicellular gland. Goblet cells secrete MUCUS. They are scattered in the epithelial linings of many organs, especially the SMALL INTESTINE and the RESPIRATORY TRACT.
An encapsulated lymphatic organ through which venous blood filters.
Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.
A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
An increased reactivity to specific antigens mediated not by antibodies but by cells.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
The giving of drugs, chemicals, or other substances by mouth.
An ascarid nematode found primarily in the small intestine of the larger Felidae as well as dogs and cats. It differs from TOXOCARA in that the larvae do not migrate through the lungs. It does occasionally produce visceral larva migrans (LARVA MIGRANS, VISCERAL) in man, although more rarely than does Toxocara.
Ducts that serve exclusively for the passage of eggs from the ovaries to the exterior of the body. In non-mammals, they are termed oviducts. In mammals, they are highly specialized and known as FALLOPIAN TUBES.
Agents causing the narrowing of the lumen of a bronchus or bronchiole.
Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.
Interactive processes between the oocyte (OVUM) and the sperm (SPERMATOZOA) including sperm adhesion, ACROSOME REACTION, sperm penetration of the ZONA PELLUCIDA, and events leading to FERTILIZATION.
Gonadotropins secreted by the pituitary or the placenta in horses. This term generally refers to the gonadotropins found in the pregnant mare serum, a rich source of equine CHORIONIC GONADOTROPIN; LUTEINIZING HORMONE; and FOLLICLE STIMULATING HORMONE. Unlike that in humans, the equine LUTEINIZING HORMONE, BETA SUBUNIT is identical to the equine choronic gonadotropin, beta. Equine gonadotropins prepared from pregnant mare serum are used in reproductive studies.
Infection of the lung often accompanied by inflammation.
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Nonsusceptibility to the pathogenic effects of foreign microorganisms or antigenic substances as a result of antibody secretions of the mucous membranes. Mucosal epithelia in the gastrointestinal, respiratory, and reproductive tracts produce a form of IgA (IMMUNOGLOBULIN A, SECRETORY) that serves to protect these ports of entry into the body.
Transfer of preovulatory oocytes from donor to a suitable host. Oocytes are collected, fertilized in vitro, and transferred to a host that can be human or animal.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The fertilized OVUM resulting from the fusion of a male and a female gamete.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Proteins which are found in eggs (OVA) from any species.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
The transfer of mammalian embryos from an in vivo or in vitro environment to a suitable host to improve pregnancy or gestational outcome in human or animal. In human fertility treatment programs, preimplantation embryos ranging from the 4-cell stage to the blastocyst stage are transferred to the uterine cavity between 3-5 days after FERTILIZATION IN VITRO.
Inflammation of the eyelids.
A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.
A genus of ascarid nematodes commonly parasitic in the intestines of cats and dogs.
A formulation for presenting an antigen to induce specific immunologic responses. It consists of an assembly of antigens in multimeric form. The assembly is attached to a matrix with a built-in adjuvant, saponin. ISCOMs induce strong serum antibody responses, and are used as highly immunogenic forms of subunit vaccines.
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention.
The plasma membrane of the egg.
An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.
A species of trematode blood flukes of the family Schistosomatidae which occurs at different stages in development in veins of the pulmonary and hepatic system and finally the bladder lumen. This parasite causes urinary schistosomiasis.
Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.
Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.
The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
Artificial introduction of SEMEN or SPERMATOZOA into the VAGINA to facilitate FERTILIZATION.
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.
Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS.
Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA.
A CC-type chemokine that is specific for CCR3 RECEPTORS. It is a potent chemoattractant for EOSINOPHILS.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.
A human disease caused by the infection of parasitic worms SCHISTOSOMA HAEMATOBIUM. It is endemic in AFRICA and parts of the MIDDLE EAST. Tissue damages most often occur in the URINARY TRACT, specifically the URINARY BLADDER.
A tri-benzene-ammonium usually compounded with zinc chloride. It is used as a biological stain and for the dyeing and printing of textiles.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
A post-MORULA preimplantation mammalian embryo that develops from a 32-cell stage into a fluid-filled hollow ball of over a hundred cells. A blastocyst has two distinctive tissues. The outer layer of trophoblasts gives rise to extra-embryonic tissues. The inner cell mass gives rise to the embryonic disc and eventual embryo proper.
Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States.
An OOCYTE-containing structure in the cortex of the OVARY. The oocyte is enclosed by a layer of GRANULOSA CELLS providing a nourishing microenvironment (FOLLICULAR FLUID). The number and size of follicles vary depending on the age and reproductive state of the female. The growing follicles are divided into five stages: primary, secondary, tertiary, Graafian, and atretic. Follicular growth and steroidogenesis depend on the presence of GONADOTROPINS.
The earliest developmental stage of a fertilized ovum (ZYGOTE) during which there are several mitotic divisions within the ZONA PELLUCIDA. Each cleavage or segmentation yields two BLASTOMERES of about half size of the parent cell. This cleavage stage generally covers the period up to 16-cell MORULA.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc.
Homeostatic control of the immune system by secretion of different cytokines by the Th1 and Th2 cells. The concentration dependent binding of the various cytokines to specific receptors determines the balance (or imbalance leading to disease).
Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.
The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.
A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
The treatment of immune system diseases by deliberate infestation with helminths. This therapy is partly based on the HYGIENE HYPOTHESIS which states that the absence of parasites increases immune dysregulation because of the lack of stimulation of REGULATORY T-CELLS.
An integrin alpha subunit of approximately 150-kDa molecular weight. It is expressed at high levels on monocytes and combines with CD18 ANTIGEN to form the cell surface receptor INTEGRIN ALPHAXBETA2. The subunit contains a conserved I-domain which is characteristic of several of alpha integrins.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Lymphoid tissue on the mucosa of the small intestine.
Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.
A neoplasm originating from thymic tissue, usually benign, and frequently encapsulated. Although it is occasionally invasive, metastases are extremely rare. It consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. Malignant lymphomas that involve the thymus, e.g., lymphosarcoma, Hodgkin's disease (previously termed granulomatous thymoma), should not be regarded as thymoma. (From Stedman, 25th ed)
Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.
Vaccines or candidate vaccines designed to prevent or treat cancer. Vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced.
Procedures to obtain viable OOCYTES from the host. Oocytes most often are collected by needle aspiration from OVARIAN FOLLICLES before OVULATION.
An early embryo that is a compact mass of about 16 BLASTOMERES. It resembles a cluster of mulberries with two types of cells, outer cells and inner cells. Morula is the stage before BLASTULA in non-mammalian animals or a BLASTOCYST in mammals.
The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Phthalic acid anhydrides. Can be substituted on any carbon atom. Used extensively in industry and as a reagent in the acylation of amino- and hydroxyl groups.
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
The number of offspring produced at one birth by a viviparous animal.
Infection by nematodes of the genus ASCARIS. Ingestion of infective eggs causes diarrhea and pneumonitis. Its distribution is more prevalent in areas of poor sanitation and where human feces are used for fertilizer.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
Allergic reaction to eggs that is triggered by the immune system.
Skin diseases caused by ARTHROPODS; HELMINTHS; or other parasites.
The capacity to conceive or to induce conception. It may refer to either the male or female.
The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus.
Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Excision of one or both of the FALLOPIAN TUBES.
Elements of limited time intervals, contributing to particular results or situations.
Techniques for the artifical induction of ovulation, the rupture of the follicle and release of the ovum.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
Sites on an antigen that interact with specific antibodies.
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.
Morphological and physiological development of EMBRYOS or FETUSES.
The application of suitable drug dosage forms to the skin for either local or systemic effects.
A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION.
Antibody-mediated immune response. Humoral immunity is brought about by ANTIBODY FORMATION, resulting from TH2 CELLS activating B-LYMPHOCYTES, followed by COMPLEMENT ACTIVATION.
An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
A branch of engineering concerned with the design, construction, and maintenance of environmental facilities conducive to public health, such as water supply and waste disposal.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response.
A class of drugs designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
The major group of transplantation antigens in the mouse.
Commonly known as parasitic worms, this group includes the ACANTHOCEPHALA; NEMATODA; and PLATYHELMINTHS. Some authors consider certain species of LEECHES that can become temporarily parasitic as helminths.
Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Group of chemokines with adjacent cysteines that are chemoattractants for lymphocytes, monocytes, eosinophils, basophils but not neutrophils.
Form of adoptive transfer where cells with antitumor activity are transferred to the tumor-bearing host in order to mediate tumor regression. The lymphoid cells commonly used are lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL). This is usually considered a form of passive immunotherapy. (From DeVita, et al., Cancer, 1993, pp.305-7, 314)
A GATA transcription factor that is found predominately in LYMPHOID CELL precursors and has been implicated in the CELL DIFFERENTIATION of HELPER T-CELLS. Haploinsufficiency of GATA3 is associated with HYPOPARATHYROIDISM; SENSORINEURAL HEARING LOSS; and renal anomalies syndrome.
A genus of intestinal parasite worms which includes one of the most important hookworms of man, NECATOR AMERICANUS. The only other known species, N. suillus, has been recovered from pigs.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.
Drugs that are used to treat asthma.
A genus of nematodes of the superfamily ASCARIDOIDEA whose species usually inhabit the intestine.
The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
Endometrial implantation of EMBRYO, MAMMALIAN at the BLASTOCYST stage.
Animals or humans raised in the absence of a particular disease-causing virus or other microorganism. Less frequently plants are cultivated pathogen-free.
Mice bearing mutant genes which are phenotypically expressed in the animals.
Schistosomiasis caused by Schistosoma mansoni. It is endemic in Africa, the Middle East, South America, and the Caribbean and affects mainly the bowel, spleen, and liver.
Conjunctivitis due to hypersensitivity to various allergens.
Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.
The fluid surrounding the OVUM and GRANULOSA CELLS in the Graafian follicle (OVARIAN FOLLICLE). The follicular fluid contains sex steroids, glycoprotein hormones, plasma proteins, mucopolysaccharides, and enzymes.
A low affinity interleukin-2 receptor subunit that combines with the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN to form a high affinity receptor for INTERLEUKIN-2.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
A glycoprotein albumin from hen's egg white with strong iron-binding affinity.
Passive or active movement of SPERMATOZOA from the testicular SEMINIFEROUS TUBULES through the male reproductive tract as well as within the female reproductive tract.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Infections or infestations with parasitic organisms. They are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
The structural and functional changes by which SPERMATOZOA become capable of oocyte FERTILIZATION. It normally requires exposing the sperm to the female genital tract for a period of time to bring about increased SPERM MOTILITY and the ACROSOME REACTION before fertilization in the FALLOPIAN TUBES can take place.
Planned management, use, and preservation of energy resources.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.

Characterization of a Caenorhabditis elegans recA-like gene Ce-rdh-1 involved in meiotic recombination. (1/3840)

A recA-like gene was identified in the Caenorhabditis elegans genome project database. The putative product of the gene, termed Ce-rdh-1 (C. elegans RAD51 and DMC1/LIM15 homolog 1), consists of 357 amino acid residues. The predicted amino acid sequence of Ce-rdh-1 showed 46-60% identity to both RAD51 type and DMC1/LIM15 type genes in several eukaryote species. The results of RNAi (RNA-mediated interference) indicated that repression of Ce-rdh-1 blocked chromosome condensation of six bivalents and dissociation of chiasmata in oocytes of F1 progeny. Oogenesis did not proceed to the diakinesis stage. Accordingly, all the eggs produced (F2) died in early stages. These results suggest that Ce-rdh-1 participates in meiotic recombination.  (+info)

Formation of mature egg envelope subunit proteins from their precursors (choriogenins) in the fish, Oryzias latipes: loss of partial C-terminal sequences of the choriogenins. (2/3840)

The inner layer of egg envelope of the medaka, Oryzias latipes, comprises two major groups of glycoprotein subunits, ZI-1,2 and ZI-3. Their precursor proteins, choriogenin H (Chg H) and choriogenin L (Chg L), respectively, are synthesized in spawning female liver. In the present study, the primary structures of the precursors and the corresponding mature subunits were compared by peptide mapping and amino acid sequencing to find what difference in their molecular structures is relevant to the assembly of the soluble precursors into the insoluble inner layer. The primary structures of the solubilized subunits were mostly identical to those of the respective precursors, but they lacked C-terminal partial sequences that their precursors possessed, namely, ZI-1,2 subunit was shorter than Chg H by 34 amino acid residues and ZI-3 was shorter than Chg L by 27 residues. In addition, a consensus amino acid sequence, Arg-Lys-X-Arg, was found at the putative cleavage sites in the C-terminal region of the precursors. It is conjectured that the truncation of the precursor proteins is prerequisite for formation of mature chorion subunit proteins and their assembly into chorion.  (+info)

Fertilization, embryonic development, and offspring from mouse eggs injected with round spermatids combined with Ca2+ oscillation-inducing sperm factor. (3/3840)

Round spermatids, precursor male gametes, are known to possess the potential to achieve fertilization and embryonic development when injected into eggs. However, injection of spermatids alone seldom activates eggs in the mouse, as spermatids by themselves cannot induce an increase in intracellular Ca2+, a prerequisite for egg activation. We injected a mouse round spermatid into an egg simultaneously with partially purified sperm factor from differentiated hamster spermatozoa. The combined injection produced repetitive Ca2+ increases (Ca2+ oscillations) lasting for at least 4 h as observed at fertilization, and induced activation in 92% of eggs. This method provided 75% fertilization success associated with male and female pronucleus formation and development to 2-cell embryos, while only 7% of eggs were fertilized by injection of a spermatid alone. Of the 2-cell embryos, approximately 50% developed to blastocysts during 5 days of culture in vitro, while no blastocysts were obtained following injection of sperm factor alone. Furthermore, the 2-cell embryos, that were created by spermatids and sperm factor and transplanted into foster mothers, developed into normal offspring, although the percentage was only 22%. All infants grew into healthy adults carrying normal chromosomes. The sperm factor served as a complementary factor for successful fertilization by round spermatid injection.  (+info)

Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation. (4/3840)

The granulomatous inflammation in infection with the helminth Schistosoma mansoni represents a cellular hypersensitivity reaction mediated by, and dependent upon, MHC class II-restricted CD4+ Th cells sensitized to parasite egg Ags. The current work examines the role and significance of the B7:CD28/CTLA-4 pathway in providing the costimulation necessary for the activation of these pathogenic T cells. In vitro T cell responses in B7-1-/- mice, 7-8 wk postinfection, were no different from wild-type controls, but the absence of B7-2 molecules resulted in a decrease in egg Ag-induced proliferation with increased IFN-gamma production. Both B7-1-/- and B7-2-/- mice exhibited intact granuloma formation. In contrast, CD4+ Th cells from B7-1/2 double-deficient mice displayed a dramatic loss of proliferative capacity upon stimulation with egg Ag. Most strikingly, these T cells secreted only IFN-gamma, but not IL-4 and IL-10, a pattern entirely opposite to that displayed by wild-type controls. Despite these major differences in T cell reactivity, B7-1/2-/- mice had only a limited reduction of granuloma size and fibrosis, without appreciable difference in cellular composition. These results show that substantial granuloma formation can occur under conditions of limited T cell expansion and restricted Th1-type cytokine production. They also support the notion that the combined effect of B7 signaling is not as critical for Th1 cell activation as it is for the development of the Th2 dominant environment characteristic of the evolving schistosome infection in H-2b mice.  (+info)

The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin. (5/3840)

Replication licensing factor (RLF) is an essential initiation factor that can prevent re-replication of DNA in a single cell cycle [1] [2]. It is required for the initiation of DNA replication, binds to chromatin early in the cell cycle, is removed from chromatin as DNA replicates and is unable to re-bind replicated chromatin until the following mitosis. Chromatography of RLF from Xenopus extracts has shown that it consists of two components termed RLF-B and RLF-M [3]. The RLF-M component consists of complexes of all six Xenopus minichromosome maintenance (MCM/P1) proteins (XMcm2-7), which bind to chromatin in late mitosis and are removed as replication occurs [3] [4] [5] [6] [7]. The identity of RLF-B is currently unknown. At least two factors must be present on chromatin before licensing can occur: the Xenopus origin recognition complex (XORC) [8] [9] and Xenopus Cdc6 (XCdc6) [10]. XORC saturates Xenopus sperm chromatin at approximately one copy per replication origin whereas XCdc6 binds to chromatin only if XORC is bound first [9] [10] [11]. Although XORC has been shown to be a distinct activity from RLF-B [9], the relationship between XCdc6 and RLF-B is currently unclear. Here, we show that active XCdc6 is loaded onto chromatin in extracts with defective RLF, and that both RLF-M and RLF-B are still required for the licensing of XCdc6-containing chromatin. Furthermore, RLF-B can be separated from XCdc6 by immunoprecipitation and standard chromatography. These experiments demonstrate that RLF-B is both functionally and physically distinct from XCdc6, and that XCdc6 is loaded onto chromatin before RLF-B function is executed.  (+info)

Ku-dependent nonhomologous DNA end joining in Xenopus egg extracts. (6/3840)

An extract from activated Xenopus eggs joins both matching and nonmatching ends of exogenous linear DNA substrates with high efficiency and fidelity (P. Pfeiffer and W. Vielmetter, Nucleic Acids Res. 16:907-924, 1988). In mammalian cells, such nonhomologous end joining (NHEJ) is known to require the Ku heterodimer, a component of DNA-dependent protein kinase. Here I investigated whether Ku is also required for the in vitro reaction in the egg extract. Immunological assays indicate that Ku is very abundant in the extract. I found that all NHEJ was inhibited by autoantibodies against Ku and that NHEJ between certain combinations of DNA ends was also decreased after immunodepletion of Ku from the extract. The formation of a joint between a DNA end with a 5'-protruding single strand (PSS) and an end with a 3'-PSS, between two ends with 3'-PSS, and between two blunt ends was most Ku dependent. On the other hand, NHEJ between two DNA ends bearing 5'-PSS was Ku independent. These results show that the Xenopus cell-free system will be useful to biochemically dissect the role of Ku in eukaryotic NHEJ.  (+info)

Purification and characterization of a serine protease with fibrinolytic activity from Tenodera sinensis (praying mantis). (7/3840)

Mantis egg fibrolase (MEF) was purified from the egg cases of Tenodera sinensis using ammonium sulfate fractionation, gel filtration on Bio-Gel P-60 and affinity chromatography on DEAE Affi-Gel blue gel. The protease was assessed homogeneous by SDS-polyacrylamide gel electrophoresis and has a molecular mass of 31500 Da. An isoelectric point of 6.1 was determined by isoelectric focusing. Amino acid sequencing of the N-terminal region established a primary structure composed of Ala-Asp-Val-Val-Gln-Gly-Asp-Ala-Pro-Ser. MEF readily digested the Aalpha- and Bbeta-chains of fibrinogen and more slowly the gamma-chain. The nonspecific action of the enzyme results in extensive hydrolysis of fibrinogen and fibrin releasing a variety of fibrinopeptide. The enzyme is inactivated by Cu2+ and Zn2+ and inhibited by PMSF and chymostatin, yet elastinal, aprotinin, TLCK, TPCK, EDTA, EGTA, cysteine, beta-mercaptoethanol, iodoacetate, E64, benzamidine and soybean trypsin inhibitor do not affect activity. Antiplasmin was not sensitive to MEF but antithrombin III inhibited the enzymatic activity of MEF. Among chromogenic protease substrates, the most sensitive to MEF hydrolysis was benzoyl-Phe-Val-Arg-p-nitroanilide with maximal activity at pH 7.0 and 30 degrees C. MEF preferentially cleaved the oxidized B-chain of insulin between Leu15 and Tyr16. D-Dimer concentrations increased on incubation of cross-linked fibrin with MEF, indicating the enzyme has a strong fibrinolytic activity.  (+info)

A novel 62-kilodalton egg antigen from Schistosoma mansoni induces a potent CD4(+) T helper cell response in the C57BL/6 mouse. (8/3840)

In infection with Schistosoma mansoni, hepatic granuloma formation is mediated by CD4(+) T helper (Th) cells sensitized to schistosomal egg antigens. There is considerable variation among infected individuals with respect to both severity of disease and the T-cell response to egg antigens. In the BL/6 mouse, the egg granulomas are relatively small and the relevant sensitizing egg antigens are largely unknown. We investigated the CD4(+) Th cell response of infected BL/6 mice to egg antigens fractionated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and found a prominent lymphoproliferative response to be directed against a 62-kDa component. With the aid of a specific T-cell hybridoma, 4E6, the 62-kDa antigen was isolated; following partial digestion with endoproteinase Glu-C, an internal amino acid sequence was found to be identical with one present in the enzyme phosphoenolpyruvate carboxykinase (PEPCK) of the organisms Caenorhabditis elegans and Treponema pallidum and to differ by one residue from PEPCK of various other species. In CD4(+) Th cells from 7.5- 8.5-week-infected BL/6 mice, the purified 62-kDa molecule elicited a potent proliferative response which, based on cytokine analysis, was of a mixed Th-1 and Th-2 type. Our results reveal a novel egg antigen of particular prominence in the BL/6 mouse and suggest that the immune response in schistosomiasis is a product of sensitization to egg antigens that may vary considerably in immunogenicity from strain to strain.  (+info)

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I have been having a lot of pain and tenderness in my lower left stomach. I am often nauseous. Twice in the last week I have suddenly started vomiting and each time I vomit large egg shaped ball ( ha...
Hello, Ive only had hens since mid-May. I am wondering if anyone has advice on how to tell between natural egg structures and possible worms. I...
BioAssay record AID 484591 submitted by ChEMBL: Antiangiogenesis of fertilized chicken egg membrane assessed as inhibition of FGF-induced blood vessel formation at 10 ug/CAM after 48 hrs by CAM assay.
Its egg season! We tend to forget, because of battery egg farming techniques, that eggs really are a seasonal food - kept in natural lighting conditions, hens lay far fewer eggs in the winter, and more in the spring and summer. Thats why eggs are associated with Easter: Theyve been a symbol of spring since - well, forever.. Between the increased egg yield, and grocery stores running specials for folks planning to dye eggs, eggs are dirt-cheap these days. Right this very minute, a dozen large eggs are on sale at my local Kroger for 66c. (A month or so back, Marsh had medium eggs - common in the early spring - 3 cartons for a buck! I bought 18 cartons!). With prices like this, its a great time to eat eggs, not just for breakfast, but lunch, dinner, and even for snacks. Eggs are endlessly versatile, not only lending themselves to a wide variety of flavors, but letting you create a number of different textures, too. For these reasons, I never get tired of eggs. (As I write this, I have a cheese ...
Egg cells are produced well before birth in a huge number of so called primordial egg cells (primordial oocytes). From the beginning on, there is a continuous process of dying, so that at birth 2 million (!) are left. That process of dying goes on after birth. At the onset of puberty there remain about 40,000 ova. Then every four weeks a number of them begin a process of maturation. Of these, only one (sometimes two or three) ovum matures, the rest dies. In total about 400 ova mature (13 per year for 30 years). At menopause, no primordial egg cells are left ...
To safely feed eggs and eliminate any risk of salmonella and biotic deficiency, it is best to avoid feeding raw eggs to your pooch and prepare it before feeding. You can boil the egg rather than fry it in additional oil or butter, this way not only are eggs safe but your furry buddy will derive numerous health benefits out of it.. So if next time while enjoying your breakfast with super delicious mouthwatering scrambled eggs you wonder can I give my dog scrambled eggs, hold on! Any additional butter, oil, milk or salt, as required for scrambled egg, is, of course, a bit too much for your dog and therefore not healthy, so avoid sharing it with your buddy and rely on simply boiled egg.. One important thing you should know is how often can dogs eat eggs? can dogs eat eggs every day or once a week? You can safely give one egg to your dog a day but more than one is not quite healthy as eggs are high in cholesterol and they do contain enzyme inhibitors which could affect the digestion, especially in ...
Sarah Godenzi is a memory-taking magic maker. With a relaxed and journalistic approach to documenting a couples most treasured moments, she seamlessly captures seemingly insignificant moments with ease, and without interference.. Telling a story from start to finish - from those moments of preparation in the morning, right through until your Grandma is kicking up her heels on the dance floor well into the night, Sarah leaves weddings feeling energised, excited, and as though she has truly made two new friends in the process.. While she excels in making every minute of your day as fun as can be, Sarah not only wants couples to adore their wedding day photos (oh, and adore them they do!), she also wants them to remember the laughs experience along the way. There is no better feeling than knowing her imagery has evoked tears of joy.. Taking pride in her work, telling stories through camera lens and capturing real and honest emotion - Sarah is not only a joy to have around, her imagery is the icing ...
How are game hens on egg laying? How often? How are the hatchings. And what can I do to help and make it better and more? Any info highly appreciated...
Mine didn t look anything like what s on Barefoot s other site . There were a bunch of them that came out all at one, and now there are none. Mine are smaller than yours BellaTao - only about 1/4 in length and less than half that in width. I realized belatedly that the tails had to indicate motility, so probably not eggs. More like an amoeba-type creature, probably water based. I ve searched and searched for references to them and have found some, but no one knows what they are and nobody else has posted pictures of them. http://curezone.com/ig/i.asp?i=29943
Did you know that you can safely eat at least one dozen eggs per week, provided theyre pasture-raised and eaten raw or very lightly cooked?
First, they extract an unfertilized egg cell from a female and enucleate the cell, or remove its nucleus, which contains the DNA. From the body of the animal to be cloned, they obtain a suitable cell, such as a skin cell, the nucleus of which contains its owners genetic blueprint. They insert this cell [or just its nucleus] into the enucleated egg and pass an electric through it. This fuses the cell with egg cytoplasm. With its new nucleus, the egg now divides and grows as if it were fertilized, and a clone of the creature from which the body cell was taken begins to develop ...
My son is currently 10 months old; Ill return back to work 1.5 weeks shy of his first birthday. Ill be gone for 11 hours then (6am to 5pm) and do not want to pump during that time. When should I start day weaning to avoid engorgement? And do I need to replace the missed nursing sessions with formula? My son is currently eating 3 meals a day (no snacks) - about a large egg size amount each meal. I was thinking about a month before I go back to work, I would start dropping afternoon
Daughters of Sarah its time to stop dressing like the heathen Put back on your royal apparel. The daughters of sarah are the most beautiful.
Sarah Sinray seeks to support people in their on-going process of healing and moving in the direction of living their life in accordance with their deepest values. Ultimately, the more we are aware of how our psyche operates the more freedom we can have because awareness precedes choice. With increasing awareness practicing many small steps many times while being kind and patient with ourselves in the process adds up to changing behaviour and becoming free from patterns that no longer serve us. Her approach tends to emphasize going deep into the roots of issues rather than simply addressing surface-level symptoms. Addressing things from their root prevents other issues from emerging later.. The underpinnings of equality, respect, authenticity, groundedness and kindness guide Sarahs work with people as does her belief that change is possible. Sometimes when people are suffering they can lose hope that things can improve. At these times being able to lean on the steadfastness of the Counsellor ...
Sarah Graysun is an American TikTok star. Is Sarah Graysun dating or still single? Also know her age, father, mother, siblings, net worth, earning, height.
Pet of the Week Sarah is an 8-year-old female. Sarah is the shelters longest resident, and the staff really cant figure out why. She has
A Rede SARAH utiliza cookies, que são arquivos que registram e gravam temporariamente no computador do usuário, para fins estatísticos e de aprimoramento de nossos serviços, as preferências e navegações realizadas nas páginas da Rede Sarah. Ao optar pelo uso de nossos serviços, o usuário concorda com a utilização desses arquivos.. ...
Last night Sarah Herron became one of the darlings on the new Bachelor. But, she said something that got people thinking. Was she really born with one arm?
Des Moiness Sarah Garner MD provides high-quality medical treatments to ensure you receive the best medical treatment possible. This facility offers a large array of medical treatments and services, including medical check-ups. Sarah Garner MD understands that getting sick can be a downer, and thats why the doctors offer kind and effective care to help you get back to feeling 100%.
Americas No. 1 Branded Egg Helps At-Home Chefs Add More Nutrition to Their Favorite MealsEggs are commonly found on grocery lists across America, however not all eggs are nutritionally equal. This fall, Egglands Best is teaming up with Taste of Home Cooking Schools to show everyday cooks why their grocery lists should read Egglands Best eggs. To ensure their eggs provide better nutrition, Egglands Best uses a unique hen feed that is all-natural and all-
How many calories in Scrambled Eggs, 2 large eggs w. 1 tbsp milk and 1 tsp fat.NutriSystem suffered one bad idea after another until Mike Hagan turned it into a lean selling machine.Nutrisystem is more than a diet plan, our program is designed to help you lose weight fast and improve your health.I partnered with Nutrisystem on this post and was compensated. Amy Orvin. What a ...
As you may recall from my last post, the current plan is IVF homework this month; stims and ER next month; detox in July; and FET in August. Not wanting to waste a single egg (what if its my only good one left?!), I naturally asked Dr. Y for permission to try the old-fashioned way…
Howlett, S.K.; Barton, S.C.; Surani, M.A., 1989: Effects of the number, stage and parental origin of nuclei in reconstructed mouse eggs
Researchers from New York Medical College and the University of California Davis have for the first time codified age-specific probabilities of live birth after in vitro fertilization (IVF) with frozen eggs. A team of researchers ...
JOHNSTON, Iowa, Dec. 16, 2014-- Biova LLC, the global leader in water soluble egg membrane, announces new executive leadership: Matt Stegenga, current director of marketing for Biova, has been named president. He succeeds Dennis Casey, PhD, who will continue with Biova as a member of its board of directors. Craig Rowles, who joins Biova in January as chief operating...
Learn why eggs are a powerful package of nutrition, including why eggs may not be bad for you overall and the biggest health benefits of eggs.
If I were to say _______ and eggs to you (and in fact, I just did), whats the first thing that comes to your mind to fill in the blank?
Visit Healthgrades for information on Dr. Sarah Pass, MMSC Find Phone & Address information, medical practice history, affiliated hospitals and more.
Visit Healthgrades for information on Dr. Sarah Lopez, DO Find Phone & Address information, medical practice history, affiliated hospitals and more.
This terrible tragedy has struck resdents of Tulameen as they trooped into the social to drop their heart felt condolonces alongside with their friends, family and neighbors.. A GoFundMe account has been created by Julie Boyer in order to provide the families relief of costs related to services, time away from work, and other unforseen expenses. Feel Free To Donate Through This LINK.. ...
PCOS: A quick guide to a common challenge including how to get tested and what you can do to maintain (or lose) weight and eat the right foods for health.
Sarah Plews had started feeling contractions the morning of December 4th. Because it was her second birth, Sarah knew it was time to head to the hospital. She arrived there around noon. But the midwives and hospital staff told Sarah that she wouldnt be giving birth immediately and that she and her husband, Dave, should go out for lunch, try to relax and come back to the hospital in a couple of hours.. So, upon the advice, Sarah, David and a care worker headed over to Caffe Gusto at the top of St. Michaels Hill for lunch. But little Ivy, who was eight days overdue, decided that she wasnt willing to wait. ...
Dr Sarah Shammas, Representing biochemistry research at Oxford University, Role of protein disorder within transcriptional regulation
Aviva Sarah Mattingly is part of Stanford Profiles, official site for faculty, postdocs, students and staff information (Expertise, Bio, Research, Publications, and more). The site facilitates research and collaboration in academic endeavors.
50 Added | 1 Magazine | 3 Likes | 2 Following | 13 Followers | @705speed | Keep up with Sarah Haan on Flipboard, a place to see the stories, photos, and updates that matter to you. Flipboard creates a personalized magazine full of everything, from world news to lifes great moments. Download Flipboard for free and search for
Ive just watched Sarah Kays TED talk, and it was wonderful and inspiring. Shes so full of life, so eager. And such a confident woman. She introduced an idea that Id like to test, and to see whether anything comes out of it. I need your participation for this, so get ready to engage. Please.…
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How does an injury like the one Sarah Burke suffered happen and can it be prevented? Orthopedic surgeon Dr. David Geier, explains in a guest article for MomsTeam.
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... chrysostoma (F.A. Schilder, 1927) Erronea ovum erici Lorenz, Bridges & Chiapponi, 2011 Erronea ovum ovum (Gmelin, ... Biolib Ovum Erronea ovum Media related to Erronea ovum at Wikimedia Commons v t e (Articles with short description, Short ... 1791) : synonym of Erronea ovum (Gmelin, 1791) Erronea ovum palauensis (F.A. Schilder & M. Schilder, 1938) Lorenz F., Bridges R ... Erronea ovum, common name the egg cowry, is a species of sea snail, a cowry, a marine gastropod mollusk in the family ...
Ovum Products of conception Kim Mackenzie-Morris. "What is a blighted ovum?". Babycentre.co.uk. Retrieved 19 December 2013. " ... A blighted ovum is a pregnancy in which the embryo never develops or develops and is reabsorbed. In a normal pregnancy, an ... A blighted ovum or anembryonic gestation is characterized by a normal-appearing gestational sac, but the absence of an embryo. ... Blighted Ovum on WebMD Anembryonic pregnancy on Radiopaedia.org Johnson, MR; Riddle, AF; Sharma, V; Collins, WP; Nicolaides, KH ...
Look up ovum in Wiktionary, the free dictionary. Ovum most commonly refers to: Ovum, oosphere or egg cell, the female gamete ... involved in oogamous sexual reproduction Ovum may also refer to: In music: Ovum Recordings, a music record label in ... Ovum Ltd., an industry analyst firm headquartered in London, England This disambiguation page lists articles associated with ... the title Ovum. If an internal link led you here, you may wish to change the link to point directly to the intended article. ( ...
"Josh Wink Presents 20 Years Ovum". "Josh Wink Celebrates Ovum 20th Anniversary".[permanent dead link] Official website Ovum on ... Ovum Recordings is a house music record label founded by Josh Wink and King Britt in October 1994. It is based in Philadelphia ... Resident Advisor Ovum Recordings discography at Discogs v t e (All articles with dead external links, Articles with dead ...
... is a species of sea snail, a marine gastropod mollusk in the family Buccinidae, the true whelks. Liomesus ovum ( ...
... , also known as the Arctic comb jelly or sea nut, is a cydippid comb jelly or ctenophore first described as Beroe ... Mertensia ovum is the major source of bioluminescence from Arctic gelatinous zooplankton. This species, like other ctenophores ... Media related to Mertensia (Ctenophora) at Wikimedia Commons Data related to Mertensia ovum at Wikispecies (CS1 maint: unfit ... doi:10.1111/j.1751-8369.1991.tb00669.x. "LHSVirtualZoo - Mertensia ovum". lhsvirtualzoo.wikispaces.com. Retrieved 12 December ...
... is a species of sea urchin of the family Temnopleuridae. Their armour is covered with spines. It came from ... Amblypneustes ovum was first scientifically described in 1816 by Jean-Baptiste de Lamarck. Amblypneustes grandis Amblypneustes ... leucoglobus Amblypneustes elevatus Kroh, A. (2010). Amblypneustes ovum (Jean-Baptiste de Lamarck, 1816). In: Kroh, A. & Mooi, R ...
An immature ovum is a cell that goes through the process of oogenesis to become an ovum. It can be an oogonium, an oocyte, or ... Thus, an immature ovum can spend up to ~55 years as a primary oocyte (the last ovulation before menopause). The secondary ... In oogenesis, it doesn't really have any significance in itself, since it is very similar to the ovum. However, it fills the ... This is the stage where immature ova spend most of their lifetime, more specifically in diplotene of prophase I of meiosis. The ...
... is a species of toxic dinoflagellates suspected to cause diarrhetic shellfish poisoning in humans. Harred, ... Laura (July 2014). "Predicting harmful algal blooms: a case study with Dinophysis ovum in the Gulf of Mexico". Journal of ...
... is endemic to the Philippines, mainly in Luzon and in the island of Panay. Ryssota ovum can normally be found ... Shells of Ryssota ovum can reach a diameter of 70-100 millimetres (2.8-3.9 in). These very large shells vary in color from pale ... Ryssota ovum is nocturnal. As darkness approaches, these land snails start to move and feed on decomposing forest debris. At ... Ryssota ovum, the polished muffin, is a species of large air-breathing land snail, a terrestrial pulmonate gastropod mollusk in ...
Jules Hewett was Ovum's longest serving Chief Executive, from 1988 to 1990 and from 1994 to 2001. In 2000, Ovum achieved ... Ovum suffered during the tech crash of the early 2000s, but had recovered by the mid-2000s and was able to float on the London ... Ovum was created in 1982 by Tim Johnson, a remote working technology journalist at The Sunday Times in London. In 1985, Johnson ... Ovum, now part of Omdia, was an independent analyst and consultancy firm headquartered in London, specializing in global ...
... is a species of freshwater snail with an operculum, an African apple snail, an aquatic gastropod mollusk in the ... Lanistes Ovum, Apple Snail Website. Freshwater Snails of Africa and Their Medical Importance Brown, D. S. (1994). Freshwater ... "Lanistes ovum". IUCN Red List of Threatened Species. 2018: e.T165799A120111809. doi:10.2305/IUCN.UK.2018-2.RLTS. ... http://www.zoologischemededelingen.nl/83/nr03/a04 Archived 2017-09-27 at the Wayback Machine Lanistes Ovum Archived 2012-05-27 ...
Juvenile Ovula ovum with orange yellow papillae looks like a toxic nudibranch Phyllidia sp. A shell of Ovula ovum This species ... Ovula ovum (Linnaeus, 1758). WoRMS (2010). Ovula ovum (Linnaeus, 1758). Accessed through: World Register of Marine Species at ... Ovula ovum with whole body covered by its mantle. This species can be easily found in the nearshore water of northeast coast of ... Ovula ovum, common name the common egg cowrie, is a species of sea snail, a marine gastropod mollusk in the family Ovulidae, ...
... and appears linked in some way to declining ova health. Studies show that obesity affects the quality of the ovum. It is a ... Ovum quality is the measure of the ability of an oocyte (the female gamete) to achieve successful fertilisation. The quality is ... Advanced maternal age represents a significant consideration for ovum health, and is currently regarded as the largest risk ... The mechanisms by which ovum health degenerates with age are incompletely understood. Extended meiotic arrest, a decline in ...
... is a species of plant in the family Solanaceae. It is endemic to Brazil. Bohs, L. (1998). "Solanum ovum ...
The hamster zona-free ovum test (HZFO test), or hamster egg-penetration test, or sometimes just hamster test, is an in-vitro ... The primary application of the test is to diagnose male infertility caused by sperm unable to penetrate the ova. The test has ... The hamster zona-free ovum test was frequently performed by sperm banks when screening potential sperm donors. However, owing ...
In the OVA series, the characters' designs and ages were changed along with other elements as part of the process of "updating ... Jun originally had long green hair but has short brown hair in the OVA, has developed physically and has worked as a model in ... The Red Impulse squadron had only three members in the original series while in the OVA continuity there are more. The film's ... At Anime Boston 2013, Sentai Filmworks had announced that they have rescued the OVA series along with the original 1970s series ...
"Scoot Ova" by 4EY The Future - Music Video - VH1.com". vh1.com. "4EY The Future - Scoot Ova - Music Video - MTV". MTV. "DMV ... Scoot Ova is a song, video, and dance created by 4EY The Future, and R&B/Pop group out of the Washington D.C. region. The dance ... " - "Scoot Ova" They Got Next". UrbanBridgez.com - Urban E-Zine. (Articles with topics of unclear notability from March 2021, ...
Ova is the plural form of ovum, the female sex cell or gamete. Ova or OVA may also refer to: Ova, Kaş, a village in the Antalya ... OVA), a protein found in egg whites .ova, filename extension in Open Virtualization Format Original video animation, anime ... Look up ova in Wiktionary, the free dictionary. ... Province, Turkey Ova, Kentucky, an unincorporated community Ovà ... films released directly to video -ova, a feminine surname suffix in Eastern Slavic naming customs This disambiguation page ...
... is a village in the District of Kaş, Antalya Province, Turkey. "Population of city, towns and villages - 2010". ...
"Bend Ova (Feat. Tyga) - Single by Lil Jon". iTunes. 22 July 2014. "Lil Jon's New Single "Bend Ova" ft. Tyga Available on iTunes ... "Bend Ova" is a single by American rapper and producer Lil Jon released on July 22, 2014 as the follow-up to his highly ... "Lil Jon - Bend Ova". Top 40 Singles. Retrieved August 14, 2014. "Lil Jon Chart History (Hot 100)". Billboard. "Lil Jon Chart ... "Lil Jon - Bend Ova". ARIA Top 50 Singles. Retrieved August 14, 2014. "Lil Jon Chart History (Canadian Hot 100)". Billboard. ...
A ova bank, or cryobank or egg cell bank, is a facility that collects and stores human ova, mainly from ova donors, primarily ... Ova donated in this way are known as donor ova. There are currently very few ova banks in existence. Generally, the main ... The ova are generally collected between 31 and 35 years of age. The procedure of collecting ova may or may not include ovarian ... Shanghai having an ova bank Age of woman when collecting ova "Archived copy" (PDF). Archived from the original (PDF) on 2012-08 ...
... is one of the singles off of rapper Nine's 1995 album Nine Livez. The chorus samples KRS-One's vocals from "Rough ...
Ova is an unincorporated community located in Magoffin County, Kentucky, United States. U.S. Geological Survey Geographic Names ... Information System: Ova, Kentucky v t e (Articles with short description, Short description is different from Wikidata, ...
In the OVA, she met him on the rooftop of Ido's clinic soon after Ido gave her a new cyborg body. In the manga, they first meet ... In the OVA, she does not do this. Vector is told by Chiren that Yugo was killed by a hunter-warrior then struck by lightning. ... Chiren only appears in the OVA. In the manga, Ido is not shown to have a love interest or woman whom he used to be involved ... His OVA appearance is also drastically different from his manga appearance. In the manga, he is only shown fighting the then- ...
The OVA series is written and directed by Yoshiaki Kawajiri, Takashi Imanishi and Ryousuke Takahashi. Kawajiri's Slipstream ...
"OVA「最遊記外伝」Blu-ray BOX". saiyuki-gaiden.com. September 28, 2018. Retrieved July 13, 2022. "アニメ「最遊記外伝」BD-BOX発売、峰倉かずやの描き下ろし特典など". ... "最遊記外伝OVA「香花の章」発売、「天上の蟻」無料配信も". natalie. Apr 26, 2013. Retrieved August 15, 2022. "Saiyuki Gaiden - Complete Collection (Blu-ray ... The OVA is based on chapters 11-13 of the Saiyuki Gaiden with additional content written by the Kazuya Minekura. The story It ... "OVA「最遊記外伝」ジャケット公開!
Ova Arthur Kelley (March 27, 1914 - December 10, 1944) was a United States Army soldier and a recipient of the United States ...
"Slayers OVA Collection". Mania.com. Retrieved 2013-09-24. Official website of Slayers OVA Collection (Madman Entertainment) ... "劇場版&OVA スレイヤーズ デジタルリマスターBD‐BOX [Blu-ray] DVD・ブルーレイ - 林原めぐみ, 川村万梨阿, 阪 脩, 高山みなみ, 白鳥由里, 平松晶子, 大塚明夫, 矢尾一樹, 内海賢二, わたなべひろし". Amazon. ... OVA Japanese Box Set Planned". Fandompost.com. 20 November 2014. Retrieved 2015-06-21. "Delayed "Slayers" Film/OVA Blu-ray Box ... After that, both OVA series were released, along with the
Ova Hamidiye is a village in the Karacabey district of Bursa Province in Turkey. "Note: Population was checked via Turkish ...
  • Stool ova and parasites exam is a lab test to look for parasites or eggs (ova) in a stool sample. (medlineplus.gov)
  • In patients with an appropriate geographic history, rule out strongyloidiasis by means of thorough evaluation, including several stool examinations for ova and parasites, special larvae detection techniques, and/or serology in all transplant candidates or others who are likely to receive a prolonged course of steroids or other immunosuppressive medications. (medscape.com)
  • Evidence of parasitic infection on stool evaluation for ova and parasites â? (who.int)
  • Stool testing for ova and parasites was negative. (medscape.com)
  • ACI Worldwide's joint report with Ovum, 2018 Global Payments Insight Survey: Merchants , discusses how retailers and other merchants are tackling challenges in an industry where a consumer's experience with customer service is now held to the highest standard. (mytotalretail.com)
  • With this in mind, Banting assessed what he heard and saw around UC&C last month at Enterprise Connect 2019 for sharing during the Ovum debriefing, which also featured contact center/customer experience-centric insight from Ken Landoline, principal analyst for customer engagement, and contributions from Mila Antonia, another principal analyst for customer engagement. (nojitter.com)
  • From 9 - 11 October, Fancom will attend OVUM 2019, the XXVI Latin American Poultry Congress in Peru, where it will show our Lumina control program, which contributes to Fancom's aim to improve operational processes in modern poultry houses. (fancom.com)
  • Soil samples from 38 specific locations, obtained on 3 different occasions, about 6 months apart, analysed for helminth ova. (who.int)
  • At the first sampling, 10.5% of the soil samples were positive for helminth ova with 7.8% and 2.6% samples showing Ascaris and Necator ova respectively. (who.int)
  • At the second sampling of the same locations nearly 40% of the samples were positive for helminth ova with 21.6%, 7.8% and 10.5% of the samples positive for Ascaris, Trichuris and Toxocara ova respectively. (who.int)
  • The larger number of samples positive for helminth ova were in the second and the third samplings which coincided with high rainfall in the pre-sampling period. (who.int)
  • That's because, as Ovum analyst Tim Banting pointed out last week in an Enterprise Connect debrief webinar , "when we look at what's happening in communications and collaboration, there's emerging value, there's value that's deliverable today, and there's value that was delivered yesterday. (nojitter.com)
  • Technology, by and large, is the easy part, added Banting, who is a principal analyst at Ovum focused on workspace services. (nojitter.com)
  • Wolfram Research's recent move into the cloud computing field and Microsoft's Windows HPC Server 2008 release are indicators that it's not just the scientific community that has ample opportunity to use HPC resources, according to David Mitchell, SVP of IT research at analyst house Ovum. (scientific-computing.com)
  • Founded in 1985, Ovum has one of the most experienced analyst teams in the industry and is a respected source of guidance for business leaders, CIOs, vendors, service providers, and regulators looking for comprehensive, accurate, and insightful market data, research, and consulting. (knect365.com)
  • Neha Dharia, Ovum senior analyst and author of the Location Platform Index: Mapping and Navigation, 2H16 report, said: "As a digital platform provider of data services built on location information, HERE is moving ahead of the changes occurring in the location and mapping industry. (here.com)
  • Steve Hotham, current MD of Ovum, will become the merged entity's CEO. (telecoms.com)
  • The merged business, which will be fully integrated by the end of May, will be led by Steve Hotham, current MD of Ovum, who will become its CEO. (informa.com)
  • 4) As in most other animals, the sperm mitochondria penetrate the cell membrane of the ovum at fertilization. (english-kannada.com)
  • Edmund Beecher Wilson in the US published An Atlas of Fertilization and Karyokinesis of the Ovum (hereafter called An Atlas) in 1895. (asu.edu)
  • The book presents photographs by photographer Edward Leaming that capture stages of fertilization, the fusion of sperm and egg and early development of sea urchin (Toxopneustes variegatus) ova, or egg cell. (asu.edu)
  • Research firms Ovum and Informa Telecoms and Media (ITM) are to merge under the Ovum brand and create what they claim to be the world's largest telecoms industry research firm. (telecoms.com)
  • By combining Ovum and ITM Research, we are assembling a unique team of readily accessible analysts, offering a comprehensive portfolio of research, data products and consulting services across telecoms, media and IT. (telecoms.com)
  • Ovum and Informa Telecoms and Media (ITM) Research, both divisions of Informa PLC, today announce their intention to combine under the Ovum brand, to create the world's largest telecoms industry research firm. (informa.com)
  • Its research draws upon over 400,000 interviews each year with business and technology, telecoms and sourcing decision-makers, giving Ovum and its clients unparalleled insight, not only into business requirements but also the technology that organisations must support. (informa.com)
  • 10-1 Inča Wide Inča Rims Ova Kategorija. (inehacarpremium.com)
  • Power4Laptops AC Adapter Za Telefon Plug) Je Kompatibilan Sa ZenFone Ova Kategorija Zidni Punjači. (w3conference.org)
  • Sa Springform Set I Curi-dokaz 4 Komada Cm/7 Cm/9 Dostupan) Ova Kategorija. (livegps.org)
  • Toxocara cati ova were found in 7 (6.3%) samples, 2 had Ascaris lumbricoides ova, 3 had larvae morphologically similar to Strongyloides stercoralis. (who.int)
  • At the third sampling, 26.2% of the samples were positive with 21%, 2.6% and 2.6% of the samples positive for Ascaris, Trichuris and Toxocara ova respectively. (who.int)
  • Group 2 innate lymphoid cells (ILC2) and CD4+ T helper cells were isolated from spleens and lungs of chicken egg ovalbumin (OVA)-challenged BALB/c mice. (cdc.gov)
  • The aim of this study was to assess how exposure to fine PM collected from Sacramento, CA, shapes the allergic airway immune response in BALB/c mice undergoing sensitization and challenge with ovalbumin (OVA). (cdc.gov)
  • Ovum is an Informa business. (informa.com)
  • Ovum is part of the Business Intelligence Division of Informa plc, a leading business intelligence, academic publishing, knowledge and events group listed on the London Stock Exchange. (knect365.com)
  • Spread across 23 offices, in 6 continents, Ovum will employ 275 staff, including 180 analysts providing a combination of global and local insight. (informa.com)
  • With 23 offices across six continents, Ovum offers a truly global perspective on technology, communications and media markets and provides clients with insight including workflow tools, forecasts, surveys, market assessments, technology audits, and opinion. (knect365.com)
  • Eggs of T. cati were recovered from 7 samples ( Table 1 ), Ascaris lumbricoides ova from 2 and larvae morphologically similar to Strongyloides stercoralis from 3. (who.int)
  • Love is war manga will contain contents of the ova episodes of the 3rd season of this issue came out on january 28, 2021. (moodleone.org)
  • You can check out a preview or watch on PC at the Bandai Channel website for the OVA (do note that you need to have a Japanese IP in order to access the movie) or you can see the mobile mini-site and download the episodes directly to your phone or mobile device by following this link . (sonicretro.org)
  • It got 12 episodes and 1 OVA. (allwish.me)
  • After downloading the anime and the OVA episodes, you can watch it anywhere, anytime without any annoying ads. (allwish.me)
  • Has anyone actually tried to import this OVA in to ESXi? (spiceworks.com)
  • When installing PowerChute Network Shutdown OVA files on VMware ESXi 6.7 Update 2 the web client may crash or the VM after deployment cannot be powered on. (apc.com)
  • Hello Team, Can I login to graylog OVA using root username? (graylog.org)
  • The first was released in Japan in 2001, while the second OVA was released in 2004. (bellaonline.com)
  • Palo Alto Networks has developed Virtualized Firewalls VM series to run in virtual environment … I have got a VM including two files (PA-VM-6.0.0.ovf and … I installed PAN OS 6.1.0 on Vmware Workstation and working finr but … https://kat.cr/palo-alto-firewall-vm-image-pa-vm-esx-6-1-0-ova-t10333460.html. (unblog.fr)
  • How to install and Download paloalto firewall image(.ova, .ovf) on VMware. (unblog.fr)
  • A computer with VMware or … of pa-vm-esx-6.1.0.ova or idea where can i download PANOS image for vm. (unblog.fr)
  • Research indicates that a blighted ovum can result from a problem with the egg or the sperm, or be caused by abnormal cell division. (wdxcyber.com)
  • The Blackwells are part of a growing movement to require anonymous sperm (and, presumably, ova) donors to disclose their medical histories and undergo genetic testing - which is not required by most states. (foxnews.com)
  • I have an even better idea: Outlaw anonymous sperm and ova donation entirely. (foxnews.com)
  • Anonymous sperm and ova donation presupposes that the biological connection between parents and children is without much value at all - since in a wholesale (or shall I say, retail) manner, we sanction an ever-increasing number of kids being born who have no idea who their biological fathers and mothers are and can never find out, period. (foxnews.com)
  • Anonymous sperm and ova donation solves no problem of any child. (foxnews.com)
  • The effects of a policy that sanctions anonymous sperm and ova donation are not known. (foxnews.com)
  • If they are informed about their origins (and I have counseled several adults conceived through anonymous sperm and ova donation who were so informed), then they can face serious questions about being abandoned and unwanted and no more than biological specimens. (foxnews.com)
  • 1) the ovum contributes one chromosome of each pair to the fertilized cell (2) When a human sperm fertilizes a human ovum , a single cell is created with the potential to grow into a human person. (english-kannada.com)
  • 3) An ovum (plural ova) is a mature egg released at ovulation. (english-kannada.com)
  • After birth, ova rest dormant and are vulnerable to environmental insults until the time of ovulation. (cdc.gov)
  • Results of search for 'su:{Ovum. (who.int)
  • Mice in the OVA + PM/OVA group displayed significantly increased airway inflammation compared to OVA/OVA animals. (cdc.gov)
  • The number of HO-1 positive alveolar macrophages was significantly elevated in lungs of mice treated with OVA + PM/OVA compared to OVA/OVA. (cdc.gov)
  • the ova must undergo a period of development in the environment before they can become infective [1]. (who.int)
  • The ovum from which the fetus is formed develops during the early fetal life of the mother. (cdc.gov)
  • Ova forming within a female fetus may be affected by exposures experienced by her mother during the mother's lifetime. (cdc.gov)
  • FACTS: The egg cell, or ovum, is the largest and most important cell in the world - and it's only found in women! (giantmicrobes.com)
  • The egg cell, or ovum, is the female reproductive cell. (giantmicrobes.com)
  • Close contact with snake excretions, such as in python tribal totemism in Africa ( 5 ) and tropical snake farming ( 2 ), as well as consumption of undercooked contaminated snake meat ( 8 ), likely plays a major role in transmission of pentastome ova to humans. (cdc.gov)
  • Adventure 4 Enperā to Hangudo Man ) is the fourth episode of the JoJo's Bizarre Adventure OVA . (jojowiki.com)
  • Amazing Nurse Nanako is a six-episode OVA series that was released in Japan on July 5, 1999. (bellaonline.com)
  • Baldr Force EXE is a four episode OVA series based on the Baldr Force 2D action-shooter game. (bellaonline.com)
  • Ovum is a market-leading data, research and consulting firm focused on helping digital service providers and their technology partners thrive in the connected digital economy. (knect365.com)
  • Healthcare providers must specifically order testing for Cyclospora, whether testing is requested by ova and parasite (O&P) examination, by molecular methods, or by a gastrointestinal pathogen panel test. (cdc.gov)
  • Install the OVA using PowerShell. (apc.com)
  • Total cells, macrophages, and eosinophils recovered in BALF lavage were significantly elevated in the OVA + PM/OVA compared to OVA/OVA group. (cdc.gov)
  • Ovum provides clients with independent and objective analysis that enables them to make better business and technology decisions. (informa.com)
  • Our investigation highlights transmission of infective A. armillatus ova to dogs and, by serologic evidence, also to 1 human, demonstrating a public health concern. (cdc.gov)
  • Histopathological grading indicated that OVA + PM/OVA treatment induced significant inflammation compared to OVA/OVA. (cdc.gov)
  • I am honored to see that Ovum recommends all actors in the industry to adopt this new business paradigm. (here.com)
  • Also find spoken pronunciation of ovum in Kannada and in English language. (english-kannada.com)
  • Exposures to developing ova can have lifelong effects. (cdc.gov)
  • It also presupposes that men or women who anonymously donate their semen or ova are not short on some facet of empathy or humanity that ultimately means we are transmitting an undesirable personality trait to future generations. (foxnews.com)
  • What ovum means in Kannada, ovum meaning in Kannada, ovum definition, examples and pronunciation of ovum in Kannada language. (english-kannada.com)