Ovary: The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.Polycystic Ovary Syndrome: A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.CHO Cells: CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.Ovarian Follicle: An OOCYTE-containing structure in the cortex of the OVARY. The oocyte is enclosed by a layer of GRANULOSA CELLS providing a nourishing microenvironment (FOLLICULAR FLUID). The number and size of follicles vary depending on the age and reproductive state of the female. The growing follicles are divided into five stages: primary, secondary, tertiary, Graafian, and atretic. Follicular growth and steroidogenesis depend on the presence of GONADOTROPINS.Cricetulus: A genus of the family Muridae consisting of eleven species. C. migratorius, the grey or Armenian hamster, and C. griseus, the Chinese hamster, are the two species used in biomedical research.Ovulation: The discharge of an OVUM from a rupturing follicle in the OVARY.Granulosa Cells: Supporting cells for the developing female gamete in the OVARY. They are derived from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the OOCYTE in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the OVUM in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors (RECEPTORS, LH).Hyperandrogenism: A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION.Ovarian Diseases: Pathological processes of the OVARY.Follicular Atresia: The degeneration and resorption of an OVARIAN FOLLICLE before it reaches maturity and ruptures.Theca Cells: The flattened stroma cells forming a sheath or theca outside the basal lamina lining the mature OVARIAN FOLLICLE. Thecal interstitial or stromal cells are steroidogenic, and produce primarily ANDROGENS which serve as precusors of ESTROGENS in the GRANULOSA CELLS.Oogenesis: The process of germ cell development in the female from the primordial germ cells through OOGONIA to the mature haploid ova (OVUM).Progesterone: The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.Follicle Stimulating Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.Oocytes: Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Gonadotropins, Equine: Gonadotropins secreted by the pituitary or the placenta in horses. This term generally refers to the gonadotropins found in the pregnant mare serum, a rich source of equine CHORIONIC GONADOTROPIN; LUTEINIZING HORMONE; and FOLLICLE STIMULATING HORMONE. Unlike that in humans, the equine LUTEINIZING HORMONE, BETA SUBUNIT is identical to the equine choronic gonadotropin, beta. Equine gonadotropins prepared from pregnant mare serum are used in reproductive studies.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Corpus Luteum: The yellow body derived from the ruptured OVARIAN FOLLICLE after OVULATION. The process of corpus luteum formation, LUTEINIZATION, is regulated by LUTEINIZING HORMONE.Chorionic Gonadotropin: A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).Ovarian Cysts: General term for CYSTS and cystic diseases of the OVARY.Luteinizing Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.Estradiol: The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.Gonadotropins: Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.Anovulation: Suspension or cessation of OVULATION in animals or humans with follicle-containing ovaries (OVARIAN FOLLICLE). Depending on the etiology, OVULATION may be induced with appropriate therapy.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Estrous Cycle: The period of cyclic physiological and behavior changes in non-primate female mammals that exhibit ESTRUS. The estrous cycle generally consists of 4 or 5 distinct periods corresponding to the endocrine status (PROESTRUS; ESTRUS; METESTRUS; DIESTRUS; and ANESTRUS).Estrus: The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.Oligomenorrhea: Abnormally infrequent menstruation.Androstenedione: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Testis: The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.Granulosa Cell Tumor: A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Sexual Maturation: Achievement of full sexual capacity in animals and in humans.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Infertility, Female: Diminished or absent ability of a female to achieve conception.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Uterus: The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.Follicular Phase: The period of the MENSTRUAL CYCLE representing follicular growth, increase in ovarian estrogen (ESTROGENS) production, and epithelial proliferation of the ENDOMETRIUM. Follicular phase begins with the onset of MENSTRUATION and ends with OVULATION.Anti-Mullerian Hormone: A glycoprotein that causes regression of MULLERIAN DUCTS. It is produced by SERTOLI CELLS of the TESTES. In the absence of this hormone, the Mullerian ducts develop into structures of the female reproductive tract. In males, defects of this hormone result in persistent Mullerian duct, a form of MALE PSEUDOHERMAPHRODITISM.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Follicular Fluid: The fluid surrounding the OVUM and GRANULOSA CELLS in the Graafian follicle (OVARIAN FOLLICLE). The follicular fluid contains sex steroids, glycoprotein hormones, plasma proteins, mucopolysaccharides, and enzymes.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Oogonia: Euploid female germ cells of an early stage of OOGENESIS, derived from primordial germ cells during ovarian differentiation. Oogonia undergo MEIOSIS and give rise to haploid OOCYTESRecombinant Proteins: Proteins prepared by recombinant DNA technology.Phosphatidic Acids: Fatty acid derivatives of glycerophosphates. They are composed of glycerol bound in ester linkage with 1 mole of phosphoric acid at the terminal 3-hydroxyl group and with 2 moles of fatty acids at the other two hydroxyl groups.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Clomiphene: A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that ENCLOMIPHENE and ZUCLOMIPHENE are the (E) and (Z) isomers of Clomiphene respectively.Fertility: The capacity to conceive or to induce conception. It may refer to either the male or female.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Androgens: Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.Receptors, FSH: Cell surface proteins that bind FOLLICLE STIMULATING HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells.Reproduction: The total process by which organisms produce offspring. (Stedman, 25th ed)Ovulation Induction: Techniques for the artifical induction of ovulation, the rupture of the follicle and release of the ovum.Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)Kinetics: The rate dynamics in chemical or physical systems.Aromatase: An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.Ovariectomy: The surgical removal of one or both ovaries.DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Inhibins: Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectivelyVitellogenesis: The active production and accumulation of VITELLINS (egg yolk proteins) in the non-mammalian OOCYTES from circulating precursors, VITELLOGENINS. Vitellogenesis usually begins after the first MEIOSIS and is regulated by estrogenic hormones.Primary Ovarian Insufficiency: Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.Gonads: The gamete-producing glands, OVARY or TESTIS.Ovum: A mature haploid female germ cell extruded from the OVARY at OVULATION.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Testicular Hormones: Hormones produced in the testis.In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Fertility Agents, Female: Compounds which increase the capacity to conceive in females.Cyclohexenes: Six-carbon alicyclic hydrocarbons which contain one or more double bonds in the ring. The cyclohexadienes are not aromatic, in contrast to BENZOQUINONES which are sometimes called 2,5-cyclohexadiene-1,4-diones.Luteal Cells: PROGESTERONE-producing cells in the CORPUS LUTEUM. The large luteal cells derive from the GRANULOSA CELLS. The small luteal cells derive from the THECA CELLS.Germ Cells: The reproductive cells in multicellular organisms at various stages during GAMETOGENESIS.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Drug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.Steroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Fertilization in Vitro: An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro.Genitalia, Female: The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Cryopreservation: Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.
Harlow, BL; Hartge, PA (Apr 1995). "A review of perineal talc exposure and risk of ovarian cancer". Regulatory toxicology and ... Suspicions have been raised that its use contributes to certain types of disease, mainly cancers of the ovaries and lungs. It ... "Talc and carcinoma of the ovary and cervix". J Obstet Gynaecol Br Commonw. 78 (3): 266-272. doi:10.1111/j.1471-0528.1971. ...
Jeggo, PA; LP Kemp (December 1983). "X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross- ... Much of her early worked involved Chinese hamster ovary cells, a commonly studied cell line also known as CHO. Using standard ...
Sabelli PA; Larkins BA (2009). "The Development of Endosperm in Grasses". Plant Physiology. 149 (1): 14-26. doi:10.1104/pp. ... Maines JZ; Stevens LM; Tong X; Stein D (2004). "Drosophila dMyc is required for ovary cell growth and endoreplication". ... Leiva-Neto JT; Grafi G; Sabelli PA; Dante RA; Woo YM; Maddock S; Gordon-Kamm WJ; Larkins BA (2004). "A Dominant Negative Mutant ...
Zuk PA, Elferink LA (2000). "Rab15 differentially regulates early endocytic trafficking". J. Biol. Chem. 275 (35): 26754-64. ... "Rab15 mediates an early endocytic event in Chinese hamster ovary cells". J. Biol. Chem. 274 (32): 22303-12. doi:10.1074/jbc. ... "Entrez Gene: RAB15 RAB15, member RAS onocogene family". Zuk PA, Elferink LA (1999). " ...
Fields PA, Eldridge RK, Fuchs AR, Roberts RF, Fields MJ (April 1983). "Human placental and bovine corpora luteal oxytocin". ... Many of the same tissues (e.g. ovaries, testes, eyes, adrenals, placenta, thymus, pancreas) where PAM (and oxytocin by default ... Wathes DC, Swann RW, Pickering BT, Porter DG, Hull MG, Drife JO (August 1982). "Neurohypophysial hormones in the human ovary". ...
Witt-Enderby PA, Dubocovich ML (Jul 1996). "Characterization and regulation of the human ML1A melatonin receptor stably ... expressed in Chinese hamster ovary cells". Molecular Pharmacology. 50 (1): 166-74. PMID 8700109. Witt-Enderby PA, Masana MI, ... monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor ...
Macías-Silva M, Hoodless PA, Tang SJ, Buchwald M, Wrana JL (1998). "Specific activation of Smad1 signaling pathways by the BMP7 ... "Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells". ...
After further treatments, Gosselin became pregnant again, and on May 10, 2004, in Hershey, Pennsylvania, at the Penn State ... Gosselin became pregnant through fertility treatment because polycystic ovary syndrome left her unable to conceive otherwise. ... Pennsylvania. She then worked as a labor and delivery nurse in Wyomissing, Pennsylvania. Kreider met Jon Gosselin at a company ... They stated that their eight children will remain in their Pennsylvania home, and the two of them will move back and forth to ...
Along with the brain, fibrillin-3 has been localized in the gonads and ovaries of field mice. Fibrillin-4 was first discovered ... in zebrafish, and has a sequence similar to fibrillin-2. PDB: 2W86​; Jensen SA, Iqbal S, Lowe ED, Redfield C, Handford PA (May ...
60(9). Baeuerle PA (1994). "Function and Activation of NF-kappaB in the Immune System" Annual Review of Immunology 12:1. Fellah ... Internal cancers can occur in the kidneys, liver, stomach, ovary, muscles or bone. Squamous cell carcinoma is a form of skin ... Kaiser P, Rothwell L, Galyov EE, Barrow PA, Burnside J, Wigley P (2000). "Differential cytokine expression in avian cells ...
Laparotomy., a clinical lectured delivered at the Hospital of the University of Pennsylvania, University Medical Magazine, ... Clinical Notes on the Extirpation of the Ovaries for Insanity."...deemed a measure of sound policy ....to stamp out insanity by ... University of Pennsylvania (1888) Laceration of the Perineum and of the Cervix, a clinical lecture delivered at the Hospital of ... the University of Pennsylvania, University Medical Magazine, University of Pennsylvania (1888) Chronic Peritonitis with Pseudo- ...
Philadelphia, PA: Saunders, Elsevier. 2013 Print. Bernadine Healy, M.D.. "Why Embryonic Stem Cells are obsolete" US News and ... Song X, Zhu CH, Doan C, Xie T (2002). "Germline stem cells anchored by adherens junctions in the Drosophila ovary niches". ... Adewumi O, Aflatoonian B, Ahrlund-Richter L, Amit M, Andrews PW, Beighton G, Bello PA, Benvenisty N, Berry LS, Bevan S, Blum B ... Philadelphia, PA: Saunders, Elsevier. 2013. Print "Stem Cells" Mayo Clinic. Mayo foundation for medical education and research ...
Pennsylvania county court reports ... - Pennsylvania. Courts - Google Books. Google Books. May 16, 2008. Retrieved October 19, ... Bennett of surgical experimentation after the removal of the ovaries of six women were reported as a cure for insanity. Under ... Annual report of the Board of ... - Pennsylvania. Board of Public Charities, Pennsylvania. Board of Public Charities. Committee ... 134-135 Pennsylvania. State Board of Health and Vital Statistics. (1900)Annual report of the State Board of Health and Vital ...
Gurbel PA, Hayes K, Bliden KP, Yoho J, Tantry US (Jan 2005). "The platelet-related effects of tenecteplase versus alteplase ... Chinese hamster ovary cells). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following ... Tenecteplase is a recombinant fibrin-specific plasminogen activator that is derived from native t-PA by modifications at three ... compared to native t-PA. The abbreviation TNK is common for referring to tenecteplase, but abbreviating drug names is not best ...
Philadelphia, PA: Holt-Saunders International. pp. 383-385. ISBN 0-03-910284-X. Moravec, František; Justine, Jean-Lou (2014). " ... Other structures and tissues of the ovaries include: Hilum of ovary The ovaries lie within the pelvic cavity, on either side of ... There is an ovary (from Latin ovarium, meaning egg' or 'nut) found on the left and the right side of the body. The ovaries also ... The ovaries are uncovered in the peritoneal cavity but are tethered to the body wall via the suspensory ligament of the ovary ...
The ovaries can stop working in about 5% of cases. This may be because the ovaries do not contain eggs. However, a complete ... permanent dead link] Freundl G; Godehardt E; Kern PA; Frank-Herrmann P; Koubenec HJ; Gnoth Ch (December 2003). "Estimated ... Physical damage to the ovaries, or ovaries with multiple cysts, may affect their ability to function. This is called ovarian ... Blocked ovaries can start functioning again without a clear medical explanation. In some cases, the egg may have matured ...
In fact, all rabbits used for the test died, because they had to be surgically opened in order to examine the ovaries. While it ... early pregnancy test developed in 1931 by Maurice Harold Friedman and Maxwell Edward Lapham at the University of Pennsylvania ... the ovaries of the mice enlarge and show follicular maturation. The test was considered reliable, with an error rate of less ... with doctors removing the ovaries from a pet rabbit in order to perform the test and keep the rabbit alive. The Aerosmith song ...
The patient, Julie Omberg, had diseased ovaries and lived to be 80 years old. There was a lynch mob waiting for Dr. Battey if ... In the same year he studied at the Obstetrical Institute of Philadelphia gaining a diploma from the University of Pennsylvania ... His field of study was gynecology, and he became well known for a procedure he pioneered to remove a woman's ovaries. Initially ... or removal of a woman's ovaries). Robert Battey was born in Augusta, Georgia to Cephas and Mary Agnes Magruder Battey. He was ...
Kaufman RJ; Sharp PA (25 August 1982). "Amplification and expression of sequences cotransfected with a modular dihydrofolate ... Chinese hamster ovary (CHO) cells are an epithelial cell line derived from the ovary of the Chinese hamster, often used in ... George Yerganian's laboratory at the Boston Cancer Research Foundation and used it to derive the original Chinese hamster ovary ... 2013). "Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome". Nature ...
The term is most often applied to teratoma on the skull sutures and in the ovaries of females. Fetus in fetu and fetiform ... Hopkins KL, Dickson PK, Ball TI, Ricketts RR, O'Shea PA, Abramowsky CR (1997). "Fetus-in-fetu with malignant recurrence". J. ... They typically form in the ovaries, testicles, or tailbone and less commonly in other areas. Symptoms may be minimal if the ... Ovarian teratomas often present with abdominal or pelvic pain, caused by torsion of the ovary or irritation of its ligaments. A ...
Baillargeon JP, McClish DK, Essah PA, Nestler JE (2005). "Association between the Current Use of Low-Dose Oral Contraceptives ... "Hirsutism and Polycystic Ovary Syndrome". American Society for Reproductive Medicine. *↑ Birth Control for Acne - http://www. ...
Women with polycystic ovary syndrome (PCOS) are also likely to suffer from oligomenorrhea. PCOS is a condition in which ... 2008 Berek JS, Adashi EY, Hillard PA. Novak's Gynecology (12th ed.). Williams & Wilkins, Baltimore (1996), ISBN 0-683-00593-6. ... excessive androgens (male sex hormones) are released by the ovaries. Women with PCOS show menstrual irregularities that range ...
The sac, also known as a prolapsed uterus, is composed of an ovary, oviduct, and sperm, and is found all over the body of the ... University of Pennsylvania. Retrieved 26 November 2013. "Sphaerularia bombi". smartsite.ucdavis.edu. Retrieved 26 November 2013 ... Once absorbed, the nutrients are digested and delivered through the ovary-oviduct to the eggs. Developing eggs from the uterine ...
Farndon PA, Morris DJ, Hardy C, McConville CM, Weissenbach J, Kilpatrick MW, Reis A (Sep 1994). "Analysis of 133 meioses places ... Hayashi T, Takao M, Tanaka K, Yasui A (Jun 1998). "ERCC1 mutations in UV-sensitive Chinese hamster ovary (CHO) cell lines". ... Lench NJ, Telford EA, Andersen SE, Moynihan TP, Robinson PA, Markham AF (Dec 1996). "An EST and STS-based YAC contig map of ...
Some fish are hermaphrodites, having both testes and ovaries either at different phases in their life cycle or, as in hamlets, ... Philadelphia, PA: Holt-Saunders International. pp. 316-327. ISBN 0-03-910284-X. Rovainen, 1985 Waldrop, Iwamoto and Haouzi, ... Synchronous hermaphrodites possess both ovaries and testes at the same time. Sequential hermaphrodites have both types of ...
O'Heard, PA; ZG Liang; CS Bambra; E Goldberg (1997). "Colinear synthesis of an antigen-specific B-cell epitope with a ... The oviducts are positioned near the ovaries where ova are produced. An ovum therefore needs only to travel a short distance to ... He, LZ; V Ramakrishna; JE Connolly; XT Wang; PA Smith; CL Jones; M Valkova-Valchanova; A Arunakumari; JF Treml; J Goldstein; PK ... Richardson, RT; P Sivashanmugam; SH Hall; KG Hail; PA Moore; SM Ruben; FS French; M O'Rand (2001). "Cloning and sequencing of ...
Pa.: Lippincott, Williams & Wilkins. p. 69. ISBN 9780781717502.. ... ovarian: Polycystic ovary syndrome. *Premature ovarian failure ...
"21 Penn Staters honored with Alumni Fellow Award , Penn State University". Retrieved 2017-06-07. Editors (2014-09-25). "GRU's ... "miRNA-93 inhibits GLUT4 and is overexpressed in adipose tissue of Polycystic Ovary Syndrome patients and women with insulin ... Cheston M. Berlin Award, Penn State Univ. College of Medicine Alumni Society, 1992 Beta Gamma Sigma Honor Society of AACSB ... Yildiz, Bulent O.; Eric Knochenhauer; Ricardo Azziz (Jan 1, 2008). "Impact of Obesity on the Risk for Polycystic Ovary Syndrome ...
... a Traditional Compound Herbal Product on Oligomenorrhea in Patients with Polycystic Ovary Syndrome: A Three-Arm, Open-label, ... Essah PA, Apridonidze T, Iuorno MJ, Nestler JE. Effects of short-term and long-term metformin treatment on menstrual cyclicity ... Hart R, Hickey M, Franks S. Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome. Best ... Balen AH, Conway GS, Kaltsas G, Techatrasak K, Manning PJ, West C et al. Polycystic ovary syndrome: the spectrum of the ...
Polycystic ovary syndrome (PCOS) is a group of health problems caused by out-of-balance hormones. It usually starts with the ... Emeritus Professor at the University of Pennsylvania School of Medicine. January 02, 2007. Additional Infertility Coverage. NEW ... Ovarian cysts are fluid-filled sacs within or on the surface of an ovary. Ovarian cysts are usually benign, and most grow, ... However, heat can also damage the ovary.. Cutting away of the cyst wall - This is the procedure of choice to decrease ...
Penn Presbyterian Medical Center; and Pennsylvania Hospital - the nations first hospital, founded in 1751. Penn Medicine also ... Women with BRCA Mutations Can Take Hormone-Replacement Therapy Safely After Ovary Removal, Penn Researchers Report at ASCO. ... Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 ... The University of Pennsylvania Health Systems patient care facilities include: The Hospital of the University of Pennsylvania ...
Penn State Clinical and Translational Science Institute (CTSI). Research output: Chapter in Book/Report/Conference proceeding ... The role of insulin-sensitising drugs in the treatment of polycystic ovary syndrome. In Current Management of Polycystic Ovary ... The role of insulin-sensitising drugs in the treatment of polycystic ovary syndrome. Current Management of Polycystic Ovary ... Legro, R. (2010). The role of insulin-sensitising drugs in the treatment of polycystic ovary syndrome. In Current Management of ...
Penn State Clinical and Translational Science Institute (CTSI). Research output: Contribution to journal › Article ... Pregnancy in Polycystic Ovary Syndrome I: Lessons from a pragmatic explanatory with repository clinical trial. Seminars in ... Pregnancy in Polycystic Ovary Syndrome I : Lessons from a pragmatic explanatory with repository clinical trial. In: Seminars in ... Pregnancy in Polycystic Ovary Syndrome I : Lessons from a pragmatic explanatory with repository clinical trial. / Legro, ...
The ATCC holdings include a vast collection of cell lines derived from ovary, representing the normal and diseased tissue of ... PA-1 [PA1] (ATCC® CRL-1572™) ATCC® Number: CRL-1572™ Organism: Homo sapiens, human ... Ovary * UACC-1598 (ATCC® CRL-3128™) ATCC® Number: CRL-3128™ Organism: Homo sapiens, human ...
Join PCOS Challenge: The National Polycystic Ovary Syndrome Association for a special Congressional Briefing on PCOS.. Date and ...
... accidentally removed a womans ovary instead of her appendix and then told bosses it was a trifling error. ... Colleagues described some of Harunas mistakes as never events Credit: PA Patient A was in pain for a month after your ... A senior surgeon with poor vision accidentally removed a womans ovary instead of her appendix and then told bosses it was a ... An expert report read: Dr Haruna was mistaken in his identification of the appendix and removed the ovary and tube in error. ...
Polycystic ovary syndrome (PCOS) is a condition in which a woman has increased levels of male hormones (androgens). Many ... Philadelphia, PA: Elsevier; 2016:chap 17.. Lobo RA. Polycystic ovary syndrome. In: Lobo RA, Gershenson DM, Lentz GM, Valea FA, ... Polycystic ovaries; Polycystic ovary disease; Stein-Leventhal syndrome; Polyfollicular ovarian disease; PCOS ... Polycystic ovary syndrome (PCOS) is a condition in which a woman has increased levels of male hormones (androgens). Many ...
Philadelphia, PA: Holt-Saunders International. pp. 383-385. ISBN 0-03-910284-X.. ... The ovary also contains blood vessels and lymphatics.[9] Function[edit]. At puberty, the ovary begins to secrete increasing ... There is an ovary (from Latin ovarium, meaning egg, nut) found on the left and right sides of the body. The ovaries also ... The ovaries are considered the female gonads.[2] Each ovary is whitish in color and located alongside the lateral wall of the ...
Are you a Doctor, Pharmacist, PA or a Nurse?. Join the Doctors Lounge online medical community ... Question: Late period, pain in ovaries and indegestion -Whats wrong?. Claudia - Fri Oct 23, 2009 10:36 am. Share , ...
Are you a Doctor, Pharmacist, PA or a Nurse?. Join the Doctors Lounge online medical community ... Question: Calcified Ovaries. fightingtree - Fri Feb 26, 2010 3:43 pm. Share , ... This time the technician said she saw several spots of calcification on my ovaries. She said it was nothing to worry about but ... There is research indicating that large calcifications in otherwise normal ovaries typically remain stable on follow-up imaging ...
Salley KE, Wickham EP, Cheang KI, Essah PA, Karjane NW, Nestler JE. Glucose intolerance in polycystic ovary syndrome--a ... Polycystic ovaries are inherited as an autosomal dominant trait: analysis of 29 polycystic ovary syndrome and 10 control ... Polycystic Ovary Syndrome as a Proinflammatory State: The Role of Adipokines. Curr Pharm Des. 2016 Jul 26. [Medline]. ... Prevalence of polycystic ovaries in women with androgenic alopecia. Eur J Endocrinol. 2003 Nov. 149(5):439-42. [Medline]. ...
Endocrine pathology of the ovary. has 2 available editions to buy at Alibris ... Endocrine pathology of the ovary. by John MacLean Morris, Robert E. Scully starting at $10.91. ... Endocrine pathology of the ovary.. by John MacLean Morris, Robert E. Scully Write The First Customer Review ...
Univ Pennsylvania. Verfahren zur vorhersage und bestimmung der ovulation und mittel zur durchfuehrung des verfahrens. ... 2. A method for diagnosing disease states in an ovary of a non-pregnant mammal in long absence of an estrous cycle comprising: ... The object of the present invention is to provide a method for examining an ovary and an apparatus therefor, which realize the ... 1 is a top plan view partly in section for showing a preferred embodiment of an apparatus for examining and diagnosing an ovary ...
Catholic Church covered up abuse of 1,000 children in Pennsylvania. Pennsylvanias Catholic Church leaders covered up the abuse ... Home » News » Opinion » Irish National Maternity Hospital: "Keep your rosaries off my ovaries!" ... Irish National Maternity Hospital: "Keep your rosaries off my ovaries!". Posted: Mon, 05 Jun 2017 by Keith Porteous Wood ... "Keep your rosaries off my ovaries!" - that was the evocative placard slogan seen when thousands of protesters marched through ...
Study of Pharmacodynamics of LIK066 in Overweight and Obese Women With Polycystic Ovary Syndrome ... Study of Pharmacodynamics of LIK066 in Overweight and Obese Women With Polycystic Ovary Syndrome Brief description of study. ... The purpose of the study is to evaluate whether LIK066 can be developed for the treatment of polycystic ovary syndrome (PCOS) ...
... enlarged ovaries with thickened sclerotic capsules and an abnormally high number of follicles are present. The follicles may ... Philadelphia, Pa: WB Saunders Co; 1994. 569-85. * Swanson M, Sauerbrei EE, Cooperberg PL. Medical implications of ... See the images of polycystic ovary disease below.. Longitudinal transabdominal sonogram of an ovary. This image reveals ... In polycystic ovary disease, enlarged ovaries with thickened sclerotic capsules and an abnormally high number of follicles are ...
Pennsylvania and the story of the descendents of Johannes Schade in Helsa Germany, 1600s-May2000. by Swan, Joy Madeleine Emilie ...
Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr LB-245. doi:10.1158/1538-7445.AM2017-LB-245 ... An IHC study of MAGI-2 was performed on normal tissue and tumor tissues from prostate (34 cases), ovary (95 cases), urinary ... MAGI-2 is overexpressed in most lymphomas and carcinomas from prostate, urinary bladder, ovary, pancreas, liver, and colon, but ... Percent positive rate of MAGI-2 was calculated for carcinomas from prostate, urinary bladder, ovary, pancreas, liver, colon, ...
Pittsburgh, Pennsylvania, United States. 14. NCT00683774. Completed. Has Results. Insulin and Polycystic Ovary Syndrome. *PCOS ... Intrauterine Environment in Polycystic Ovary Syndrome (PCOS) Probands. *Polycystic Ovary Syndrome. Observational. *Eunice ... Effects of Flutamide on Insulin and Glucose Metabolism in Women With Polycystic Ovary Syndrome. *Polycystic Ovary Syndrome ... Blood Vessel Function in Adolescents and Women With Polycystic Ovary Syndrome. *Polycystic Ovary Syndrome (PCOS) ...
Penn State College of Medicine, Penn State Milton S Hershey Medical Center. ... Genetics Home Reference related topics: Polycystic ovary syndrome MedlinePlus related topics: Polycystic Ovary Syndrome Vitamin ... Penn State College of Medicine, Penn State Milton S. Hershey Medical Center. ... Vitamin D for the Treatment of Women With Polycystic Ovary Syndrome (PCOS). The safety and scientific validity of this study is ...
Kaufman RJ, Sharp PA. Construction of a modular dihydrofolate reductase cDNA gene: analysis of signals utilized for efficient ... Kaufman RJ, Sharp PA. Construction of a modular dihydrofolate reductase cDNA gene: analysis of signals utilized for efficient ... coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary ... coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary ...
Ovarian overproduction of androgens is a condition in which the ovaries make too much testosterone. This leads to the ... Philadelphia, PA: Elsevier; 2016:chap 17.. Gibson M, Huddleston HG. Polycystic ovary syndrome and hirsutism. In: Kliegman RM, ... Tumors of the ovaries and polycystic ovary syndrome (PCOS) can both cause too much androgen production. ... Philadelphia, PA: Elsevier; 2017:chap 40.. Rosenfield RL, Barnes RB, Ehrmann DA. Hyperandrogenism, hirsutism, and polycystic ...
Chinese hamster ovary. IPs. inositol phosphates. NA. noradrenaline. NMDG. N-methyl-d-glucamine. NSCC. nonselective cation ... Insel PA. (1991) Intracellular Ca2+ and protein kinase C interact to regulate alpha 1-adrenergic- and bradykinin receptor- ... We constructed Chinese hamster ovary (CHO) cells stably expressing α1A-, α1B-, or α1D-adrenergic receptors (CHO-α1A, CHO-α1B, ... 1996) Endothelin-1-induced mitogenic responses of Chinese hamster ovary cells expressing human endothelinA: the role of a ...
  • The decrease in cancer risk from ovary removal comes at the cost of early menopause and menopausal symptoms including hot flashes, mood swings, sleep disturbances and vaginal dryness - quality-of-life issues that may cause some women to delay or avoid the procedure. (healthcanal.com)
  • In this group of women - who have BRCA1/2 mutations and who have had their ovaries removed while they are quite young - HRT should be discussed and considered an option for treating menopausal symptoms. (healthcanal.com)
  • What other symptoms are there for polycystic ovary syndrome? (thesun.co.uk)
  • While the symptoms of polycystic ovaries are varied, so too are the treatment options. (thesun.co.uk)
  • An IHC study of MAGI-2 was performed on normal tissue and tumor tissues from prostate (34 cases), ovary (95 cases), urinary bladder (92 cases), pancreas (88 cases), liver (2 cases), colon (2 cases), and lymphoma (185 cases). (aacrjournals.org)
  • Several lines of indirect evidence suggest that plasminogen activators (PAs) plays a crucial role in degradation of the follicular wall during ovulation However, single deficient mice lacking tissue-type PA (tPA), urokinase-type PA (uPA) or PA-inhibitor type 1 (PAI-I) gene function were recently found to have normal reproduction although mice with a combined deficiency of tPA and uPA were significantly less fertile. (hku.hk)
  • Coamplification and coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary cells. (atcc.org)
  • The production of progesterone, androgens, and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro. (springer.com)
  • Regulation of follicle maturation in the human ovary: a role for 5-reduced androgens. (springer.com)
  • Although about 1 million oocytes are present at birth in the human ovary, only about 500 (about 0.05%) of these ovulate, and the rest are wasted. (wikipedia.org)
  • Instead, they stay in the ovaries with a small amount of fluid (cyst) around them. (medlineplus.gov)
  • Each small cyst represents a follicle, that contains a single egg that is attempting to develop to a stage where it will be ready to be released from the ovary. (fertilityauthority.com)
  • Quinn's doctor suspected a cyst on her ovary. (mainlinehealth.org)
  • Cariker M, Dockerty MB (1954) Mucinous cyst-adenomas and mucinous cystadenocarcinomas of the ovary: A clinical pathologic study of 355 cases. (springer.com)
  • When the oocyte finishes its maturation in the ovary, a surge of luteinizing hormone secreted by the pituitary gland stimulates the release of the oocyte through the rupture of the follicle, a process called ovulation . (wikipedia.org)
  • To dissect the mechanisms behind the reduced ovulation in PA deficient mice, we have studied the regulation of plasmin activity in the ovary. (hku.hk)
  • It occurs when the sacs the ovaries sit in are unable to release an egg, which means ovulation doesn't happen. (thesun.co.uk)
  • There is proliferation of the surface epithelium of the ovary. (nih.gov)
  • The protein expression of MAGI-2 was higher in tumor cells than in their adjacent normal tissues from prostate, urinary bladder, ovary, pancreas, lymph node, liver, and colon. (aacrjournals.org)
  • Research has shown that in women who carry the BRCA mutations, the single most powerful risk-reduction strategy is to have their ovaries surgically removed by their mid-30s or early 40s. (healthcanal.com)
  • However, not all women with the condition will have ovaries with this appearance. (medlineplus.gov)
  • Coronary heart disease risk factors in women with polycystic ovary syndrome. (medscape.com)
  • Women who have polycystic ovary syndrome can reduce their changes of long-term complications by maintaining a normal weight through healthy diet and regular exercise. (medlineplus.gov)
  • As was discovered over time, women may have polycystic ovaries, yet their cases may not conform to all of the original criteria for this condition. (medscape.com)
  • Despite 2 out of 15 women exhibiting Polycystic Ovary Syndrome, there's quite a bit of misinformation circulating about the syndrome. (phillymag.com)
  • PARTICIPANTS: By linkage with the Swedish patient register, 3787 births among women with a diagnosis of polycystic ovary syndrome and 1,191,336 births among women without such a diagnosis. (biomedsearch.com)
  • They don't stop the ovaries from making estrogen, so they are only helpful in lowering estrogen levels in women after menopause. (cancer.org)
  • Are Young Adult Women with Polycystic Ovary Syndrome Slipping through the Healthcare Cracks? (upenn.edu)
  • A common problem in women younger than 50, called polycystic ovary syndrome . (aspirus.org)
  • Among the 600,000 American women who have hysterectomies (click for more research) each year, thousands may die prematurely of heart disease because doctors removed their ovaries along with their wombs, a new study suggests. (athenainstitute.com)
  • But the study, which is being published today in the journal Obstetrics & Gynecology, suggests that women and their doctors should be less reflexive about removing the ovaries during a hysterectomy and more aware of the benefits that ovaries continue to provide well into middle age. (athenainstitute.com)
  • Doctors' conversations with older women about ovary removal used to be ''brief and pointed. (athenainstitute.com)
  • The analysis found that 9 percent fewer women whose ovaries had been removed between ages 50 and 54 lived to see their 80th birthdays than did those who had hysterectomies during those years but who had kept their ovaries. (athenainstitute.com)
  • Normal functioning of ovaries in women stops whe. (home-remedies-for-you.com)
  • POLYCYSTIC ovary syndrome affects one in five women and has an impact on how ovaries function - meaning sufferers can struggle to release an egg to be fertilised making it often extremely difficult to fall pregnant. (thesun.co.uk)
  • However, women with polycystic ovaries often fail to ovulate or ovulate infrequently, which means they have irregular or absent periods. (thesun.co.uk)
  • Barbara Bernhardt , MS, CGC , a genetic counselor at the Hospital of the University of Pennsylvania, and colleagues contacted a small group of women who are participating in a larger Columbia University study investigating the use of a genetic test called a DNA microarray to identify the possibility of prenatal chromosomal abnormalities. (healthcanal.com)
  • Alterations in granulosa cell aromatase activity accompanying preovulatory follicular development in the rat ovary with evidence that 5alpha-reduced C19 steroids inhibit the aromatase reaction in vitro. (springer.com)
  • The older a woman was when she had her ovaries removed, the smaller was the impact on her chances of reaching 80, said Parker, who runs a clinical practice in Santa Monica, Calif., and who is a clinical professor at the University of California, Los Angeles School of Medicine. (athenainstitute.com)
  • Czernobilsky B (1977) Cystadenofibroma, adeno-fibroma and malignant adenofibroma of the ovary. (springer.com)
  • Ovary, Epithelium - Hyperplasia, in a female F344/N rat from a chronic study. (nih.gov)
  • Ovary, Epithelium - Hyperplasia should always be diagnosed and given a severity grade. (nih.gov)
  • LHRH agonists (sometimes called GnRH agonists ) switch off estrogen production by the ovaries. (cancer.org)