The surgical removal of one or both ovaries.
Surgical removal or artificial destruction of gonads.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.
The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
A phase of the ESTROUS CYCLES that follows METESTRUS. Diestrus is a period of sexual quiescence separating phases of ESTRUS in polyestrous animals.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The measurement of an organ in volume, mass, or heaviness.
Achievement of full sexual capacity in animals and in humans.
The use of hormonal agents with estrogen-like activity in postmenopausal or other estrogen-deficient women to alleviate effects of hormone deficiency, such as vasomotor symptoms, DYSPAREUNIA, and progressive development of OSTEOPOROSIS. This may also include the use of progestational agents in combination therapy.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.
The period of cyclic physiological and behavior changes in non-primate female mammals that exhibit ESTRUS. The estrous cycle generally consists of 4 or 5 distinct periods corresponding to the endocrine status (PROESTRUS; ESTRUS; METESTRUS; DIESTRUS; and ANESTRUS).
Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
A phase of the ESTROUS CYCLE that precedes ESTRUS. During proestrus, the Graafian follicles undergo maturation.
Bone loss due to osteoclastic activity.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
The discharge of an OVUM from a rupturing follicle in the OVARY.
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
A state of sexual inactivity in female animals exhibiting no ESTROUS CYCLE. Causes of anestrus include pregnancy, presence of offspring, season, stress, and pathology.
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.
One of the ESTROGEN RECEPTORS that has marked affinity for ESTRADIOL. Its expression and function differs from, and in some ways opposes, ESTROGEN RECEPTOR BETA.
The surgical removal of one or both testicles.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
An OOCYTE-containing structure in the cortex of the OVARY. The oocyte is enclosed by a layer of GRANULOSA CELLS providing a nourishing microenvironment (FOLLICULAR FLUID). The number and size of follicles vary depending on the age and reproductive state of the female. The growing follicles are divided into five stages: primary, secondary, tertiary, Graafian, and atretic. Follicular growth and steroidogenesis depend on the presence of GONADOTROPINS.
The period following ESTRUS during which the phenomena of estrus subside in those animals in which pregnancy or pseudopregnancy does not occur.
One of the ESTROGEN RECEPTORS that has greater affinity for ISOFLAVONES than ESTROGEN RECEPTOR ALPHA does. There is great sequence homology with ER alpha in the DNA-binding domain but not in the ligand binding and hinge domains.
A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Pregnenes with one double bond or more than three double bonds which have undergone ring contractions or are lacking carbon-18 or carbon-19..
A hollow part of the alveolar process of the MAXILLA or MANDIBLE where each tooth fits and is attached via the periodontal ligament.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.
Elements of limited time intervals, contributing to particular results or situations.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.
Collection of granular epithelial cells in the uterine muscle beneath the placenta that develop during pregnancy in certain species of animals.
Hormones secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR) that stimulate gonadal functions in both males and females. They include FOLLICLE STIMULATING HORMONE that stimulates germ cell maturation (OOGENESIS; SPERMATOGENESIS), and LUTEINIZING HORMONE that stimulates the production of sex steroids (ESTROGENS; PROGESTERONE; ANDROGENS).
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
An acyclic state that resembles PREGNANCY in that there is no ovarian cycle, ESTROUS CYCLE, or MENSTRUAL CYCLE. Unlike pregnancy, there is no EMBRYO IMPLANTATION. Pseudopregnancy can be experimentally induced to form DECIDUOMA in the UTERUS.
Abnormal distention of the STOMACH due to accumulation of gastric contents that may reach 10 to 15 liters. Gastric dilatation may be the result of GASTRIC OUTLET OBSTRUCTION; ILEUS; GASTROPARESIS; or denervation.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
MAMMARY GLANDS in the non-human MAMMALS.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
PLANT EXTRACTS and compounds, primarily ISOFLAVONES, that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS.
Delay in the attachment and implantation of BLASTOCYST to the uterine ENDOMETRIUM. The blastocyst remains unattached beyond the normal duration thus delaying embryonic development.
(6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione. A synthetic progestational hormone used in veterinary practice as an estrus regulator.
A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectively
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.
Transport of the OVUM or fertilized ovum (ZYGOTE) from the mammalian oviduct (FALLOPIAN TUBES) to the site of EMBRYO IMPLANTATION in the UTERUS.
A sebaceous gland that, in some animals, acts as an accessory to the lacrimal gland. The harderian gland excretes fluid that facilitates movement of the third eyelid.
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed)
In horses, cattle, and other quadrupeds, the joint between the femur and the tibia, corresponding to the human knee.
Peptides, natural or synthetic, that stimulate the release of PITUITARY HORMONES. They were first isolated from the extracts of the HYPOTHALAMUS; MEDIAN EMINENCE; PITUITARY STALK; and NEUROHYPOPHYSIS. In addition, some hypophysiotropic hormones control pituitary cell differentiation, cell proliferation, and hormone synthesis. Some can act on more than one pituitary hormone.
A plant genus of the family VITACEAE. Cissus rufescence gum is considered comparable to TRAGACANTH.
The yellow body derived from the ruptured OVARIAN FOLLICLE after OVULATION. The process of corpus luteum formation, LUTEINIZATION, is regulated by LUTEINIZING HORMONE.
Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
Excision of one or both adrenal glands. (From Dorland, 28th ed)
The amount of a substance secreted by cells or by a specific organ or organism over a given period of time; usually applies to those substances which are formed by glandular tissues and are released by them into biological fluids, e.g., secretory rate of corticosteroids by the adrenal cortex, secretory rate of gastric acid by the gastric mucosa.
An order of small mammals comprising two families, Ochotonidae (pikas) and Leporidae (RABBITS and HARES). Head and body length ranges from about 125 mm to 750 mm. Hares and rabbits have a short tail, and the pikas lack a tail. Rabbits are born furless and with both eyes and ears closed. HARES are born fully haired with eyes and ears open. All are vegetarians. (From Nowak, Walker's Mammals of the World, 5th ed, p539-41)
Twisting of the STOMACH that may result in gastric ISCHEMIA and GASTRIC OUTLET OBSTRUCTION. It is often associated with DIAPHRAGMATIC HERNIA.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The process of bone formation. Histogenesis of bone including ossification.
A genus of the family Muridae having three species. The present domesticated strains were developed from individuals brought from Syria. They are widely used in biomedical research.

Relaxin is a potent renal vasodilator in conscious rats. (1/4238)

The kidneys and other nonreproductive organs vasodilate during early gestation; however, the "pregnancy hormones" responsible for the profound vasodilation of the renal circulation during pregnancy are unknown. We hypothesized that the ovarian hormone relaxin (RLX) contributes. Therefore, we tested whether the administration of RLX elicits renal vasodilation and hyperfiltration in conscious adult, intact female rats. After several days of treatment with either purified porcine RLX or recombinant human RLX 2 (rhRLX), effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) increased by 20%-40%. Comparable renal vasodilation and hyperfiltration was also observed in ovariectomized rats, suggesting that estrogen and progesterone are unnecessary for the renal response to rhRLX. The nitric oxide synthase inhibitor Nomega-nitro-L-arginine methyl ester completely abrogated the increase in ERPF and GFR elicited by chronic administration of purified porcine RLX. In contrast, the renal vasoconstrictory response to angiotensin II was attenuated by the RLX treatment. Short-term infusion of purified porcine RLX to conscious rats over several hours failed to increase ERPF and GFR. Plasma osmolality was consistently reduced by the chronic administration of both RLX preparations. In conclusion, the renal and osmoregulatory effects of chronic RLX administration to conscious rats resemble the physiological changes of pregnancy in several respects: (a) marked increases in ERPF and GFR with a mediatory role for nitric oxide; (b) attenuation of the renal circulatory response to angiotensin II; and (c) reduction in plasma osmolality.  (+info)

Steroid regulation of retinol-binding protein in the ovine oviduct. (2/4238)

Two studies were conducted to identify retinol-binding protein (RBP) expression in the ovine oviduct and to determine the role of ovarian steroids in its regulation. Ewes were salpingectomized on Days 1, 5, or 10 of their respective estrous cycles, and oviducts were homogenized for RNA analysis, fixed for immunocytochemistry (ICC), or cultured for 24 h for protein analysis. ICC localized RBP to the epithelium of all oviducts. RBP synthesis was demonstrated by immunoprecipitation of radiolabeled RBP from the medium of oviductal explant cultures. Explant culture medium from oviducts harvested on Day 1 contained significantly more RBP than medium from oviducts collected on Days 5 or 10. Slot-blot analysis demonstrated that steady-state RBP mRNA levels were significantly higher on Day 1 than Day 5 or 10. In the second experiment, ovariectomized ewes were treated with estradiol-17beta (E2), progesterone (P4), E2+P4 (E2+P4), or vehicle control, and oviducts were analyzed as above. P4 alone or in combination with E2 significantly reduced steady-state RBP mRNA levels compared to those in E2-treated animals. Oviductal explants from E2- and E2+P4-treated animals released 3- to 5-fold more RBP into the medium than control and P4 treatments as determined by ELISA. RBP synthesis of metabolically labeled RBP was increased by E2 and E2+P4 treatments. This study demonstrates that P4 applied on an estradiol background negatively regulates RBP gene expression in the oviduct whereas estradiol appears to stimulate RBP synthesis and secretion.  (+info)

Effect of shellfish calcium on the apparent absorption of calcium and bone metabolism in ovariectomized rats. (3/4238)

Fossil shellfish powder (FS) and Ezo giant scallop shell powder (EG) were rendered soluble with lactate and citrate under decompression (FSEx and EGEx, respectively) and we examined the effects of lactate-citrate solubilization of FS and EG on mineral absorption, tissue mineral contents, serum biochemical indices and bone mineral density (BMD) in ovariectomized (OVX) rats. The apparent absorption ratios of minerals tended to be high in the rats fed with the solubilized mineral sources, those in the FSEx group being significantly higher than in the FS group. There was no significant difference in the tibia mineral content among the OVX groups. BMD at the distal femoral diaphysis was significantly increased by FSEx and EGEx feeding. It is suggested that solubilization with lactate and citrate under decompression increased the solubility and bioavailability of calcium from such natural sources of shellfish calcium as FS and EG.  (+info)

Expression of calcium binding protein D-9k messenger RNA in the mouse uterine endometrium during implantation. (4/4238)

To investigate the molecular mechanisms of implantation, we constructed a cDNA library of mouse uteri enriched with pregnancy-induced genes by subtractive hybridization and polymerase chain reaction (PCR). One of the isolated clones was the cDNA for the calcium binding protein D-9k (Cabp9k), which is considered to regulate intracytoplasmic concentration and transport of free calcium ions. Northern blot and in-situ hybridization analyses demonstrated that the Cabp9k mRNA was expressed in the endometrial epithelia, both luminal and glandular, in the uterus at the time of implantation. On pregnancy day 5 it was detected in the luminal, but not in the glandular, epithelia. In the oophorectomized adult mice, progesterone enhanced Cabp9k mRNA expression in the uterus, whereas oestrogen did not. Consistent with this, a nucleotide change was identified in the first intron of mouse Cabp9k gene corresponding to the oestrogen responsive element in the rat Cabp9k gene. Transfer of embryos into the uterine cavity of pseudopregnant mice reduced the expression of Cabp9k mRNA in the glandular epithelium, suggesting that Cabp9k mRNA expression is also regulated by embryonal signal(s). These findings demonstrated that Cabp9k mRNA is expressed in the endometrial epithelia during the implantation period under the control of progesterone and the presence of embryo, and suggest that CaBP9k plays a role in implantation by regulating the local calcium concentrations.  (+info)

Estrogen provides neuroprotection in transient forebrain ischemia through perfusion-independent mechanisms in rats. (5/4238)

BACKGROUND AND PURPOSE: Estrogen-related neuroprotection in association with animal models of transient forebrain and focal ischemia has been documented in several recent reports. Some of those studies indicated that part of that benefit was a function of improved intraischemic vasodilating capacity. In the present study we examined whether chronic estrogen depletion and repletion affected ischemic neuropathology through perfusion-independent mechanisms. METHODS: Normal, ovariectomized (OVX), and OVX female rats treated with 17beta-estradiol (E2) were subjected to 30 minutes of transient forebrain ischemia (right common carotid occlusion plus hemorrhagic hypotension) and reperfusion. Neurological function and brain histopathology were assessed over the 72-hour recovery period. In all rats, preischemic and intraischemic cortical cerebral blood flow (CBF) levels were monitored with laser-Doppler flowmetry. In additional rats, CBF changes in the striatum and hippocampus were also monitored with laser-Doppler flowmetry probes and radiolabeled microspheres. In each experiment, the level of ischemia was targeted to a 75% to 80% reduction in cortical CBF. RESULTS: The similarity in ischemic severity among groups was supported by measurements of comparable patterns of electroencephalographic power changes during the ischemic period. Compared with normal females, OVX rats showed diminished neurological outcomes and more severe histopathology in the hippocampus and striatum. Two-week treatment of OVX rats with E2 was accompanied by postischemic neuropathological changes similar to those seen in normal females. Intraischemic CBF reductions in the hippocampus and striatum were similar in all groups (to 35% to 50% of the preischemic value) but significantly less than the cortical CBF reductions. CONCLUSIONS: These findings indicate that estrogen provides ischemic neuroprotection through mechanisms unrelated to improvement of intraischemic cerebral perfusion.  (+info)

Androgen influence on lacrimal gland apoptosis, necrosis, and lymphocytic infiltration. (6/4238)

PURPOSE: Previous studies have shown that ovariectomy and hypophysectomy cause regression of the lacrimal gland and have implicated androgens as trophic hormones that support the gland. The purposes of this study were to test the hypothesis that glandular regression after ovariectomy is due to apoptosis, to identify the cell type or types that undergo apoptosis, to survey the time course of the apoptosis, and to determine whether ovariectomy-induced apoptosis could be prevented by dihydrotestosterone (DHT) treatment. METHODS: Groups of sexually mature female New Zealand White rabbits were ovariectomized and killed at various time periods up to 9 days. Additional groups of ovariectomized rabbits were treated with 4 mg/kg DHT per day. At each time period, sham-operated rabbits were used as controls. Lacrimal glands were removed and processed for analysis of apoptosis as assessed by DNA fragmentation and for morphologic examination. DNA fragmentation was determined using the TdT-dUTP terminal nick-end labeling assay and by agarose gel electrophoresis. Labeled nuclei were quantified by automated densitometry. Sections were also stained for RTLA (rabbit thymic lymphocyte antigen), rabbit CD18, and La antigen. Morphology was evaluated by both light and electron microscopy. RESULTS: The time course of apoptosis exhibited two phases, a rapid and transient phase and a second prolonged phase. A transient phase peaked at approximately 4 to 6 hours after ovariectomy. The values for degraded DNA as a percentage of total nuclear area were 4.29%+/-0.79% and 4.26%+/-0.54%, respectively. The values for sham-operated controls examined at the same time periods were 1.77%+/-0.08% and 0.82%+/-0.21%, respectively. The percentage of degraded DNA at 24 hours after ovariectomy was not different from controls examined at the same interval after sham operation. The percentage of degraded DNA 6 days after ovariectomy was significantly increased (8.5%+/-2.4%), compared with sham-operated animals at the same time period (0.68%+/-0.03%). DNA laddering was more pronounced after ovariectomy. Dihydrotestosterone treatment in ovariectomized rabbits suppressed the increase in DNA degradation. Morphologic examination of lacrimal gland sections indicated that ovariectomy caused apoptosis of interstitial cells rather than acinar or ductal epithelial cells. Tissue taken 4 hours and 6 days after ovariectomy showed nuclear chromatin condensation principally in plasma cells. Increased numbers of macrophages were also evident. Significant levels of cell degeneration and cell debris, characteristic of necrosis, were observed in acinar regions 6 days after ovariectomy. Dihydrotestosterone prevented this necrosis. Increased numbers of RTLA+, CD18+, and La+ interstitial cells were also evident 6 days after ovariectomy. In addition, ovariectomy increased La expression in ductal cells. Dihydrotestosterone treatment prevented the increase in numbers of lymphoid cells and La expression. Dihydrotestosterone also promoted the appearance of mitotic figures in acinar cells and increased the sizes of acini by 43% (P < 0.05). CONCLUSIONS: Glandular atrophy observed after ovariectomy is likely to proceed by necrosis of acinar cells rather than apoptosis. This process begins with an apparent time lag after a rapid phase of interstitial cell apoptosis. These processes are accompanied by increased lymphocytic infiltration. These results suggest that a critical level of androgen is necessary to maintain lacrimal gland structure and function and that a decrease in available androgen below this level could trigger lacrimal gland apoptosis and necrosis, and an autoimmune response. Because apoptotic and necrotic cell fragments may be sources of autoantigens that can be processed and presented to initiate an autoimmune reaction, we surmise that cell death triggered by androgen withdrawal may trigger an autoimmune response such as that encountered in Sjogren's syndrome. (ABSTRACT TRUNCATED)  (+info)

Effect of long-term food restriction on pituitary sensitivity to cLHRH-I in broiler breeder females. (7/4238)

The effect of long-term food restriction on the sensitivity of the pituitary to exogenously administered chicken luteinizing hormone releasing hormone I (cLHRH-I) was investigated in three groups of broiler breeder females fed ad libitum, fed a restricted quantity of food or fed a restricted quantity of food to obtain an intermediate body weight between those of the first two groups. At 16 weeks of age, basal FSH release was higher in ad libitum fed birds, culminating in ovarian development and subsequent oestradiol production by the small follicles. At this age, LH secretion was independent of ovarian feedback factors. In all groups, cLHRH-I was most active in releasing LH in intact and ovariectomized animals and, to a lesser extent, in releasing FSH in ovariectomized birds. At 39 weeks of age, basal FSH concentrations were similar among intact animals of all groups, whereas LH concentrations differed among groups, with higher values in the restricted birds. This food effect was enhanced in ovariectomized birds. Furthermore, the high response to cLHRH-I in the ovariectomized, restricted birds compared with the ad libitum, ovariectomized group suggests an improved sensitivity of the hypothalamic-pituitary axis. In conclusion, birds fed ad libitum showed the highest responsiveness to ovarian factors and to cLHRH-I in releasing FSH in the period before sexual maturity. No effect of amount of feeding could be observed for LH. However, during the egg laying period, LH release by cLHRH-I was highly dependent on amount of feeding and on ovarian feedback regulation. This finding indicates that the amount of feeding can modify the sensitivity of the pituitary to cLHRH-I, and possibly to gonadal hormones, during the laying period.  (+info)

Suppression of the secretion of luteinizing hormone due to isolation/restraint stress in gonadectomised rams and ewes is influenced by sex steroids. (8/4238)

In this study we used an isolation/restraint stress to test the hypothesis that stress will affect the secretion of LH differently in gonadectomised rams and ewes treated with different combinations of sex steroids. Romney Marsh sheep were gonadectomised two weeks prior to these experiments. In the first experiment male and female sheep were treated with vehicle or different sex steroids for 7 days prior to the application of the isolation/restraint stress. Male sheep received either i.m. oil (control rams) or 6 mg testosterone propionate injections every 12 h. Female sheep were given empty s.c. implants (control ewes), or 2x1 cm s.c. implants containing oestradiol, or an intravaginal controlled internal drug release device containing 0.3 g progesterone, or the combination of oestradiol and progesterone. There were four animals in each group. On the day of application of the isolation/restraint stress, blood samples were collected every 10 min for 16 h for the subsequent measurement of plasma LH and cortisol concentrations. After 8 h the stress was applied for 4 h. Two weeks later, blood samples were collected for a further 16 h from the control rams and ewes, but on this day no stress was imposed. In the second experiment, separate control gonadectomised rams and ewes (n=4/group) were studied for 7 h on 3 consecutive days, when separate treatments were applied. On day 1, the animals received no treatment; on day 2, isolation/restraint stress was applied after 3 h; and on day 3, an i. v. injection of 2 microg/kg ACTH1-24 was given after 3 h. On each day, blood samples were collected every 10 min and the LH response to the i.v. injection of 500 ng GnRH administered after 5 h of sampling was measured. In Experiment 1, the secretion of LH was suppressed during isolation/restraint in all groups but the parameters of LH secretion (LH pulse frequency and amplitude) that were affected varied between groups. In control rams, LH pulse amplitude, and not frequency, was decreased during isolation/restraint whereas in rams treated with testosterone propionate the stressor reduced pulse frequency and not amplitude. In control ewes, isolation/restraint decreased LH pulse frequency but not amplitude. Isolation/restraint reduced both LH pulse frequency and amplitude in ewes treated with oestradiol, LH pulse frequency in ewes treated with progesterone and only LH pulse amplitude in ewes treated with both oestradiol and progesterone. There was no change in LH secretion during the day of no stress. Plasma concentrations of cortisol were higher during isolation/restraint than on the day of no stress. On the day of isolation/restraint maximal concentrations of cortisol were observed during the application of the stressor but there were no differences between groups in the magnitude of this response. In Experiment 2, isolation/restraint reduced the LH response to GnRH in rams but not ewes and ACTH reduced the LH response to GnRH both in rams and ewes. Our results show that the mechanism(s) by which isolation/restraint stress suppresses LH secretion in sheep is influenced by sex steroids. The predominance of particular sex steroids in the circulation may affect the extent to which stress inhibits the secretion of GnRH from the hypothalamus and/or the responsiveness of the pituitary gland to the actions of GnRH. There are also differences between the sexes in the effects of stress on LH secretion that are independent of the sex steroids.  (+info)

To conduct this study, Dr. Rocca and colleagues followed women who had undergone unilateral or bilateral ovariectomy between 1950 and 1987 while residing in Olmsted County, Minn., home of Mayo Clinic. All of these women had the surgery prior to menopause and for reasons other than cancer. The study evaluated 1,293 women with unilateral ovariectomy, 1,097 women with bilateral ovariectomy and, for comparison, 2,390 women who had not undergone ovariectomy. All women were followed until their deaths or until the end of the study, which was staggered between 2001 and 2006, via a combination of interviews with the women or a surviving relative, medical records and death certificates. A unique strength of this study, according to the investigators, was a 25- to 30-year median follow-up time. A total of 1,292 ...
TY - JOUR. T1 - Effects of morphine and naloxone on glucose metabolism in uterine strips from ovariectomized and non-ovariectomized restricted diet rats. AU - Campos, M. L.. AU - Casalino-Matsuda, S. M.. AU - Linares, J. A.. AU - Goldraij, A.. N1 - Funding Information: The authors thank Gabriela Díaz Cortez for her critical correction of this manuscript. This work has been supported by grants of CONICET, CONICOR and SECYT (UNC).. PY - 2000. Y1 - 2000. N2 - The effect of underfeeding over glucose metabolism in uteri isolated from ovariectomized and non-ovariectomized rats subjected to a restricted diet for 25 days (50% of the normal food intake), was studied. Underfeeding decreases 14CO2 formation from U14 C-glucose in intact animal uteri. While in ovariectomized rats (25 days), the effect is the opposite. The addition of morphine 10-6 M to the medium does not affect rats fed ad libitum. However, 14CO2 levels increase significantly in intact animals receiving a restricted diet. In ovariectomized ...
Fingerprint Dive into the research topics of Growth hormone protects against ovariectomy-induced bone loss in states of low circulating Insulin-like Growth Factor (IGF-1). Together they form a unique fingerprint. ...
Rationale: There is a special role for estrogens in preventing and curing cardiovascular disease in women. Soy isoflavone (SI), a soy-derived phytoestrogen, is a group of biologically active plant substances with chemical structures which are similar to that of an endogenous estrogen-estradiol.. Objective: We ought to elucidate possible mechanism of SI to improve myocardial ischemia/reperfusion (MI/R) injury in ovariectomized rats.. Methods and Results: Female SD rats were underwent bilateral ovariectomy or sham ovariectomy. One week later, rats were randomly divided into several groups and began to feed soy-free chow: sham ovariectomy operation (control group), ovariectomy with MI/R or ovariectomy with sham MI/R. Other ovariectomy rats were given different doses of SI dissolved in 0.5% carboxymethycellulose (CMC-Na) by gavage. Additional ovariectomy rats were administrated with the same volume of CMC-Na by gavage or 50 μg/kg·d of 17β-estradiol (E2) by subcutaneous injection. After four-week ...
Madularu D, Athanassiou M, Yee JR, Kenkel WM, Carter CS, Mumby DG (2014) Oxytocin and object preferences in the male prairie vole. Peptides. [PubMed] [Content]. Madularu D, Athanassiou M, Yee JR, Mumby DG (2014) Centrally-administered oxytocin promotes preference for familiar objects at a short delay in ovariectomized female rats. Behav Brain Res 274C:164-167. [PubMed] [Content]. Gervais NJ, Barrett-Bernstein M, Sutherland RJ, Mumby DG (2014) Retrograde and anterograde memory following selective damage to the dorsolateral entorhinal cortex. Neurobiol Learn Mem 116C:14-26. [PubMed] [Content]. Gervais NJ, Jacob S, Brake WG, Mumby DG (2014) Modulatory effect of 17-beta estradiol on performance of ovariectomized rats on the Shock-Probe test. Physiol Behav 131:129-135. [PubMed] [Content]. Gervais NJ, Jacob S, Brake WG, Mumby DG (2013) Systemic and intra-rhinal-cortical 17-beta estradiol administration modulate object-recognition memory in ovariectomized female rats. Horm Behav 64:642-652. [PubMed] ...
The present study was designed to test the effect of acute endogenous estrogen deprivation on endothelium-dependent vasodilation in women in reproductive age. Therefore, in a group of female patients who underwent bilateral ovariectomy for uterine leiomyoma, we evaluated the forearm vascular response to acetylcholine and sodium nitroprusside, an endothelium-dependent and -independent vasodilator, respectively. As control subjects we selected healthy women well matched with the study group population for demographic and clinical parameters. Particular attention was paid to risk factors impairing endothelial function such as age, blood pressure, phase of the menstrual cycle, lipid and glucose profile, and smoking history. In the two study populations, the response to acetylcholine and sodium nitroprusside was similar, indicating preserved endothelium-dependent vasodilation in patients with leiomyoma. In contrast, after bilateral ovariectomy, the response to acetylcholine was found to be reduced ...
To our knowledge, this is the first population-based study to establish a link between oophorectomy, adiposity, and mortality. We identified a subgroup of women who were at a greater risk of death following oophorectomy. Obese women who underwent oophorectomy before the age of 40 years had nearly 2-fold increased mortality, primarily due to CVD, compared with nonobese women with intact ovaries. The magnitude of this effect was greater than that expected, given the independent effects of both obesity and oophorectomy on mortality. Furthermore, among women who did not report use of HRT, obese women who had an oophorectomy before the age of 40 years were nearly 3 times more likely to die than nonobese women with intact ovaries. This relationship persisted after excluding those with oophorectomy conducted before the age of 35 years.. A few population-based, cross-sectional studies have shown an association between oophorectomy and adiposity. A study of 1,052 women ages 40 to 69 years in Norway ...
Silicon (Si) deficiency in animals results in bone defects. Choline-stabilized orthosilicic acid (ch-OSA) was found to have a high bioavailability compared to other Si supplements. The effect of ch-OSA supplementation was investigated on bone loss in aged ovariectomized (OVX) rats. Female Wistar rats (n = 58, age 9 months) were randomized in three groups. One group was sham-operated (sham, n = 21), and bilateral OVX was performed in the other two groups. OVX rats were supplemented orally with ch-OSA over 30 weeks (OVX1, n = 20; 1 mg Si/kg body weight daily) or used as controls (OVX0, n = 17). The serum Si concentration and the 24-hour urinary Si excretion of supplemented OVX rats was significantly higher compared to sham and OVX controls. Supplementation with ch-OSA significantly but partially reversed the decrease in Ca excretion, which was observed after OVX. The increase in bone turnover in OVX rats tended to be reduced by ch-OSA supplementation. ch-OSA supplementation increased significantly ...
Fingerprint Dive into the research topics of PI3K modulates estrogen-dependent facilitation of colon-to-urethra cross-organ reflex sensitization in ovariectomized female rats. Together they form a unique fingerprint. ...
The vascular consequences of estrogen treatment may be driven by its initiation timing. We tested the hypothesis that the duration of ovarian hormone deprivation before estrogen reintroduction affects the role of estrogen as mediator of endothelial f
To investigate the role of sex steroids in sex differences in the response of rats to the potent inflammatory mediator bradykinin (BK), we evaluated the effect of sex steroid manipulation on the magnitude of BK-induced synovial plasma extravasation (PE). The magnitude of BK-induced PE is markedly less in females. Ovariectomy of female rats increased BK-induced PE, and administration of 17beta-estradiol to ovariectomized female rats reconstituted the female phenotype. Castration in male rats decreased BK-induced PE, and administration of testosterone or its nonmetabolizable analog dihydrotestosterone reconstituted the male phenotype. The results of these experiments strongly support the role of both male and female sex steroids in sex differences in the inflammatory response. Because the stress axes are sexually dimorphic and are important in the regulation of the inflammatory response, we evaluated the contribution of the hypothalamic-pituitary-adrenal and the sympathoadrenal axes to sex differences in
OVX rat studies. Animals, diets, and surgery. Animal protocols were approved by the Animal Care and Use Committee at SmithKline Beecham Pharmaceuticals Inc. Six-month-old virgin Sprague-Dawley rats were purchased from Charles River Laboratories Inc. (Wilmington, Massachusetts, USA). They were provided with unrestricted access to tap water and commercial rodent chow (Diet 5001; PMI Nutrition International, Brentwood, Missouri, USA) throughout the study. When the rats were 7 months old, they were subjected either to a bilateral ovariectomy or to sham surgery, and then held for a further 3 months to allow the development of osteopenia. At that time, each rat was anesthetized with isoflurane, and bone mineral density (BMD) was quantified in the lumbar spine, distal femur, and proximal tibia by dual-energy x-ray absorptiometry (QDR-4500A; Hologic Inc., Waltham, Massachusetts, USA).. Study 1. The OVX rats were divided into 3 groups (n = 10-14 per group) that were matched by lumbar BMD. One group of ...
6221 8457627 / +6221 8458258 [email protected] ABSTRACT. Backgroud: Cognitive function impaired in the elderly is not a disease but it can be considered as a Preclinical Alzheimers Disease (AD) one of the most common dementia in the elderly. Results of research on tempe and tofu showed the effects on different cognitive functions. The aims of this study were to analized the effect of tempe and tofu flours cognitive function in ovariectomized female rats. Method: Seventy two (72) white female Sprague Dawley strain rats, aged 12 months used for this study. Before the intervention 52 rats had ovariectomy (OVx) surgical treatments and were grouped into 5 intervention groups: tempe flour, tofu flour, estradiol, casein; and non ovariectomy. Cognitive function was measured using a labyrin. Processing and data analysis, used One-Way ANOVA with Polynomial Contrass Post Hoc LSD. Results: Based on difference test between the tempe flour group (8 weeks) with baseline 2(after OVx) showed that increased ...
Rodent ovariectomy is an experimental method to eliminate the main source of sexual steroids. This work explored for the first time the ovariectomy temporal changes induced in the hemostatic coa...
TY - JOUR. T1 - Gender modulation of Ca2+ uptake in cardiac mitochondria. AU - Arieli, Yehuda. AU - Gursahani, Hemamalini. AU - Eaton, Matt M.. AU - Hernandez, Lisa A.. AU - Schaefer, Saul. PY - 2004/8. Y1 - 2004/8. N2 - Background: Mitochondrial calcium overload is an important factor in defining ischemia/reperfusion injury. Since pre-menopausal women are relatively protected from ischemia and heart disease, we tested the hypothesis that gender differences alter Ca2+ handling in rat cardiac mitochondria. Methods: Using cardiac mitochondria isolated from male, female, and ovariectomized Sprague-Dawley rats, we measured mitochondrial calcium transport, redox state, and membrane potential (Δψm) during exposure to a calcium bolus. Redox state was modulated using either succinate (S) or succinate and pyruvate (SP) as substrates. Results: Net Ca2+ uptake rates were significantly lower in female than male mitochondria using SP, substrate conditions that resulted in a lower redox state (NADH/NAD+). ...
Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.
The objective of the present study was to evaluate growth and development of corpus luteum (CL) using protein, DNA analysis and PCNA labeling index throughout the estrous cycle in goats. Non pregnant goats (n=20), 12 months of age were assigned for estrus synchronization. Goats CL were obtained from days 3, 8, 13 and 18 of estrous cycle using bilateral ovariectomy and blood samples were taken for plasma progesterone (P4) concentration. The CL was weighed, and samples of each were fixed in Carnoys solution. Additional samples of each CL were frozen and stored at -70 °C until analyzed for tissue DNA and protein. Luteal fresh weight and DNA contents increased (P,0.01) from day 3 to day 8, were similar between days 8 and 13, and then decreased (P,0.01 ...
Slot blot hybridization analysis of RNA isolated from the ventromedial hypothalamus indicated that estrogen treatment increased PE mRNA levels in the VL-VM of ovariectomized female rats (2.2-fold), but had no measurable effect on PE mRNA levels in gonadectomized males ...
This study evaluates the effect of hydrolyzed collagen (HC) on bone health of ovariectomized mice (OVX) at different ages. Twenty-six weeks after the OVX procedure, HC ingestion was still able to impr
List of words make out of Ovariectomized. Anagrams and Words made out of Ovariectomized. Find Scrabble Point of Ovariectomized. Definition of Ovariectomized. Puzzle Solver.
Did you know that there is more than one way to spay your dog? Learn about the difference and why your vet might suggest one method over the other.
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List of words make out of Oophorectomies. Anagrams of word Oophorectomies. Words made after scrabbling Oophorectomies. Word Creation helps in Anagrams and Puzzles.
Oophorectomy, sometimes called ovariectomy, is a surgical procedure that involves the removal of one or both of a womans ovaries.
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Spaying and neutering are surgical procedures used to prevent pets from reproducing. In a female animal, spaying consists of removing the ovaries or uterus and ovaries. The technical term is ovariectomy or ovariohysterectomy. For a male animal, neutering involves the removal of the testicles, and this is known as castration.. In addition to preventing unwanted offspring, spaying or neutering has many health and behavioural benefits to the animal.. ...
Doctors give unbiased, helpful information on indications, contra-indications, benefits, and complications: Dr. Jones singer on resume exercise oophorectomy: I dont think one needs to refrain from sexual activity for more than a few days but your eye doctor can give you a better answer. However if you plan to have sex under water, then the answer would be different. :).
Privatklinik Bethanien offers Oophorectomy procedures starting from Price on request and it is specialized in Gynecology treatments.
The brains and bodies of young female rats can be accelerated into puberty by the presence of an older male or by stimulation of the genitals.. 0 Comments. ...
At the margins of viability wks. Dhea may also be found, but serious side effects include headache, ushing, chills, myalgia, wheezing, tachycardia, lower back to folklore and greek mythology, it has been considered for biopsy-proven rare cases of ascites. In calculating the following: Ml of calcium from bone. Bowel sounds. Assessment of gh levels. Introduction of steroid remains empiric. Common conditions causing chest pains, a full medical history cannot be excluded by measuring free thyroid hormone replacement, or using over-the-counter drug treatments in a serous carcinoma. Untreated, it runs supercially around the tumor to appear in the lev- els of stress incontinence, which may be confused with delusional disorder, few signicant differentiating factors exist for completed suicide see box. Antibodies have a highish expulsion rate. ; cheng, ; horie et al. Suggested monitoring guide please refer to an acute are. Forms that can happen. Chronic active hepatitis % drug-induced lupus % myasthenia ...
TY - JOUR. T1 - Does cortisol acting via the type II glucocorticoid receptor mediate suppression of pulsatile luteinizing hormone secretion in response to psychosocial stress?. AU - Breen, Kellie M. AU - Oakley, Amy E. AU - Pytiak, Andrew V. AU - Tilbrook, Alan John. AU - Wagenmaker, Elizabeth R. AU - Karsch, Fred J. PY - 2007. Y1 - 2007. N2 - This study assessed the importance of cortisol in mediating inhibition of pulsatile LH secretion in sheep exposed to a psychosocial stress. First, we developed an acute psychosocial stress model that involves sequential layering of novel stressors over 3-4 h. This layered-stress paradigm robustly activated the hypothalamic-pituitary-adrenal axis and unambiguously inhibited pulsatile LH secretion. We next used this paradigm to test the hypothesis that cortisol, acting via the type II glucocorticoid receptor (GR), mediates stress-induced suppression of pulsatile LH secretion. Our approach was to determine if an antagonist of the type II GR (RU486) reverses ...
BioAssay record AID 170311 submitted by ChEMBL: Effect on serum cholesterol level as tissue specific estrogen agonist assay in ovariectomized rat model: significant decrease at
Patterns of pulsatile luteinizing hormone secretion before and during the onset of puberty in boys: a study using an immunoradiometric assay.: To study spontane
The present study was undertaken to investigate the protective effects of ethanol extract from the root of Morinda Officinalis (RMO) on ovariectomy-induced bone loss. Administration of RMO extract increased trabecular bone mineral content and bone mineral density of tibia, improved the levels of phosphorus (P), calcium (Ca) and OPG, decreased the levels of DPD/Cr, TRAP, ACTH and corticosterone, but did not reverse the levels of ALP, TNF-α and IL-6 in serum of ovariectomized rats. These findings demonstrated that RMO extract reduced bone loss in ovariectomized rats, probably via the inhibition of bone resorption, but was not involved with bone formation. Anthraquinones and polysaccharides from Morinda officinals could be responsible for their antiosteoporotic activity, and the action mechanism of these constituents needs to be further studied. Therefore, RMO has the potential to develop a clinically useful antiosteoporotic agent.
The presence of asymmetry in the capacity of the left and right ovaries to secrete testosterone was analyzed by studying the effects of hemiovariectomy along the estrus cycle one hour after surgery. The effects of ether anesthesia on hormone serum levels were also analyzed. Bilateral ovariectomy and the extirpation of the left ovary performed on the day of proestrus resulted in significantly lower testosterone levels. Compared to the anesthetized group, the effects of perforating the peritoneum unilaterally varied according to the day of the estrous cycle and the side of the peritoneum surgery was performed on. Injecting atropine sulfate (ATR) to control or anesthetized rats on D1 resulted in a significant increase of testosterone serum levels. The effects of perforating the peritoneum on testosterone levels depended on the cholinergic innervation and varied along the estrous cycle. Blocking the cholinergic system before performing unilateral or bilateral ovariectomy had different effects depending on
Abstract: This study was done to investigate the effects of fermented soy pulp on the osteoporosis in ovariectomized rats. Sprague-Dawley female rats were randomly assigned to four groups as Sham Control (SC), Ovariectomized Control (OC), Ovariectomized and Soy Pulp (OSP) fed and Ovariectomized and Fermented Soy Pulp (OFSP) fed. All rats were fed on purified diets, supplemented with non-fermented and fermented soy pulp on basic diet for 7 weeks. It was observed that isoflavone aglycone was very high in soy pulp fermented for 12 h in comparison to non-fermented soy pulp. Body weight of the rats increased significantly (p,0.05) in comparison to other groups. Atrophy of uterus in OFSP group was significantly (p,0.05) prevented in comparison to OC group. The concentration of estradiol in OFSP group was higher than those of OC and OSP groups. The bone density in OFSP group was significantly (p,0.05) higher than those of OC and OSP groups. The histopathology indicated that OFSP group has better ...
Gonadal steroids are known to influence hippocampal physiology in adulthood. It is presently unknown whether gonadal steroids influence the morphology of hippocampal neurons in the adult intact rat brain. In order to determine whether female sex hormones influence hippocampal morphology in the intact adult, we performed Golgi impregnation on brains from ovariectomized rats and ovariectomized rats which received estradiol or estradiol and progesterone replacement. Removal of circulating gonadal steroids by ovariectomy of adult female rats resulted in a profound decrease in dendritic spine density in CA1 pyramidal cells of the hippocampus. Estradiol replacement prevented the observed decrease in dendritic spine density; progesterone augmented the effect of estradiol within a short time period (5 hr). Ovariectomy or gonadal steroid replacement did not affect spine density of CA3 pyramidal cells or granule cells of the dentate gyrus. These results demonstrate that gonadal steroids are necessary for ...
The majority of cases with ovarian cancer are sporadic, not hereditary. Women with no documented germ line mutation or family history suspicious for genetic risk for ovarian cancer are considered to be at average risk. Women at increased genetic risk for ovarian cancer, especially those with BRCA1 and BRCA2 germ line mutations are at high risk of ovarian cancer and Lynch syndrome, and it is preferred to undergo risk-reducing bilateral salpingo-oophorectomy [10].. Several studies suggest a generally negative health effect when prophylactic bilateral salpingo-oophorectomy is performed before the age of menopause. Bilateral oophorectomy causes immediate drop in hormone levels of ovary that may affect long-term health. Women undergoing bilateral oophorectomy experience vaginal dryness, dyspareunia and loss of libido as a result of abrupt decline in circulating estrogen and testosterone levels [11]. Normally, for many years after menopause ovaries continue to produce androgens which are converted to ...
TY - JOUR. T1 - Circulatory responses to systemic infusions of estrone and estradiol-17α in nonpregnant, oophorectomized ewes. AU - Rosenfeld, Charles R.. AU - Rivera, Richard. PY - 1978/10/15. Y1 - 1978/10/15. N2 - Uterine arterial blood flow dose-response curves to systemic infusions of either estrone (E1) or estradiol-17α (E2α) were determined in ten oophorectomized, nonpregnant ewes. Maximum uterine blood flow occurred with 5 μg per kilogram of E1 and ≥ 20 μg per kilogram of E2α. Total uterine blood flow measured with isotope-labeled microspheres rose more than tenfold following 30 μg per kilogram of either estrogen, as did blood flow to the myometrium, endometrium, and uterine caruncles (p , 0.05). Distribution of uterine blood flow was unaltered. Cervical and vaginal blood flows increased ten-to twenty-fold with E1 and E2α, while mammary gland blood flow rose 54 and 77 per cent. Significant increases in adrenal and thyroid blood flows were documented. The only significant ...
This study was performed to investigate the impact of autonomic dysfunction of the cardiovascular system and its association with the incidence of mortality in diabetic female rats that underwent ovarian hormone deprivation. In addition, we aimed to study the effects of exercise training, as a nonpharmacologic approach to treating diabetes and ovariectomy induced dysfunctions. Two important insights can be gained from the present study. First, the diabetic OVX rats presented increased autonomic dysfunction and mortality compared with normoglycemic rats. Second, TDO rats showed autonomic function improvement and a lower mortality than SDO rats.. Previous reports12,20 demonstrated that ovarian hormone deprivation in rats increases AP to levels higher than that observed in intact female and male rats.12,20-23 The AP values obtained in the SO rats in the present study were also increased in relation to the values documented in previous studies in intact female or male rats. Similarly, the incidence ...
SHULGAU, Zarina et al. Osteoprotective Properties of RNA-Containing Drug Osteochondrin S on the Model of Insufficiency of Sex Hormones in Rats. Int. J. Morphol. [online]. 2017, vol.35, n.4, pp.1233-1238. ISSN 0717-9502. http://dx.doi.org/10.4067/S0717-95022017000401233.. The aim of the study was to evaluate the osteoprotective properties of RNA-containing drug Osteochondrin S on rats with experimental model of osteoporosis. Osteochondrin S contains yeast RNA and RNA of connective tissue of cattle. In order to model osteoporosis in rats bilateral ovariectomy was used. Rats were divided into 3 groups: 1 - ovariectomized rats receiving Osteochondrin S; 2 - ovariectomized rats receiving saline; 3 - sham-ovariectomized rats. Rats in group 1 received Osteochondrin S, Group 2 - physiological saline three times a week for 12 weeks. Based on morphological data and on the results of densitometry, Osteochondrin S prevents a decrease in bone density, i.e. exhibits osteoprotective properties. Under the ...
Results μCT analysis of the distal femur metaphysis showed that bone volume/tissue volume (BV/TV) and trabecular number (Tb.N) were significantly less in the OVX group than in the SHAM group, whereas trabecular separation (Tb.Sp) was significantly greater in the OVX group than in the SHAM group. In the TPTD and ALN group, BV/TV and Tb.N were significantly greater than in the OVX group, whereas Tb.Sp was significantly less than in the OVX group. And in the ALN group, BV/TV and Tb.N were significantly greater than in the TPTD group, but Tb.Sp was no significance.. The 50% withdrawal threshold was significantly lower in the OVX group than in the SHAM group, and it was significantly higher in the TPTD and ALN group than in the OVX group. And the 50% withdrawal threshold was no significance between the TPTD and ALN group.. The expression levels of TNF-α was increased in the OVX group compared with those in the SHAM group. Other cytokines were not increased significantly in the OVX group. In the ...
1-(Morpholinomethyl)-4-phthalimido-piperidindione-2,6 (CG 603) had a greater therapeutic effect than bilateral ovariectomy, estrogen (mestranol, 17α-ethinylestradiol-3-methylether), or androgen (drostanolone propionate, 2α-methyldihydrotestosterone propionate, 2α-MDTP) on 7,12-dimethylbenzanthracene-induced tumors in Sprague-Dawley rats. The antitumor activity of CG 603 was equivalent to hypophysectomy. Combined treatment with CG 603 and ovariectomy or estrogen gave no significant increase in antitumor activity over that with CG 603 alone. The combined treatment with CG 603 and 2α-MDTP showed a significantly higher regression of tumor weight and tumor number than the treatment with CG 603 or 2α-MDTP alone. While CG 603 in higher concentrations decreases the body weight of experimental animals, the combination of CG 603 in lower concentration with the anabolically acting 2α-MDTP increases the body weight of the treated animals. CG 603 probably exerts its antitumor activity primarily via ...
This study was performed to determine the effects of fermented Pueraria radix on lipid and bone metabolism in ovariectomized (OVX) rats. Sprague-Dawley rats were divided into 4 groups: A sham operated control group, an OVX control group, an OVX group, treated Pueraria radix and OVX group treated fermented Pueraria radix. Rats were fed experimental diets with Ca and P free for 8 weeks after ovariectomy. The femur weight was significantly increased in the treatment groups, compared with that of the control group. Abdominal fat mass and serum alanine aminotransferase and aspartate aminotransferase activities and serum triglyceride, total cholesterol, LDL-cholesterol and osteocalcin levels in the treatment groups were significantly decreased compared with the control group. Serum estradiol level in the treatment groups was significantly increased compared with the control group. Bone mineral density of the femur in the fermented Pueraria radix treatment groups was significantly increased than the ...
A Chinese herbal preparation, QingE formula (QEF), has been used clinically for treating osteoporosis in postmenopausal women by virtue of its kidney-invigorating function; however, no evidence base links QEF to estrogen replacement therapy. In this study, we undertake a characterization of estrogenic activity of QEF using an in vivo model of ovariectomized (OVX) mice together with in vitro studies with the MCF-7 cells for further molecular characterization. OVX mice were treated intragastrically with QEF at doses of 0.85, 1.7, and 3.4 g/kg per day for 4 weeks. QEF treatments restored the estrus cycle and demonstrated significant estrogenic activity, as indicated by reversal of uterine atrophy (six-fold increase in uterine weight), reduction in rectal temperature, and increased expression (1.6-fold) of estrogen receptors (ERs) in the uterus. Notably, the largest changes in these three parameters were found at the lowest dose. At the highest dose of QEF, significant changes were found in adrenal ...
Effects of alpha-lipoic acid on ischemia-reperfusion-induced renal dysfunction in rats. / Bae, Eun Hui; Lee, Kyun Sang; Lee, Jongun; Ma, Seong Kwon; Kim, Nam Ho; Choi, Ki Chul; Frøkiaer, Jørgen; Nielsen, Søren; Kim, Sun Young; Kim, Sung Zoo; Kim, Suhn Hee; Kim, Soo Wan.. In: American Journal of Physiology: Renal Physiology, Vol. 294, No. 1, 2007, p. F272-80.. Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review ...
Female gender, which is abolished following ovariectomy and reproductive senescence, is associated with improved outcome following cerebral stroke. Estrogen replacement partially restores this benefit of the female gender but the effect of progesterone in hormone-deficient animals is currently unknown. We evaluated various outcomes following middle cerebral artery occlusion (MCAO) in ovariectomised female mice, with a physiologically relevant restoration of progesterone levels. Ovariectomised female mice had significantly elevated plasma (P=,0.05) and brain progesterone levels (P=,0.01) following implantation of a 21-day release pellet (50mg) compared with mice that received placebo implants 7 days prior to undergoing 60 min MCAO. Assessment of well-being (body weight recovery) and neurological score at 24h and 48h post-MCAO indicated that MCAO significantly worsened outcome compared with sham-operated mice but progesterone had no effect. MCAO resulted in a substantial lesion formation and a ...
Effect of Ledebouriella seseloides Extracts on Lipid Parameters in Ovariectomized Rats - ALP;collagen;Ledebouriella seseloides;lipid parameters;ovariectomized rats;
M. A. Jackson, Iwaniec, U. T., Turner, R. T., Wronski, T. J., and Kalra, S. P., Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats., Peptides, vol. 32, no. 8, pp. 1575-80, 2011. ...
Two experiments of divergent selection for uterine efficiency in rabbits were performed. Rabbit does were unilaterally ovariectomized and a laparoscopy was made at mid-gestation to observe the number of corpora lutea and implanted embryos in the functional genital tract. Selection was based on the number of fetuses which died between implantation and birth in the first experiment, and on litter size in the second one, both using BLUP on an animal model. This paper presents the average values of observed traits and their heritability. Results show that an effective overcrowding of one uterine hom was obtained at implantation. The additive genetic variability of embryonic survival seems to be greater than that of fetal survival. Some differences in heritabilities between intact and unilaterally ovariectomized females tend to appear ...
Sexual dimorphism in blood pressure has been associated with differential expression of the angiotensin II (AII) receptors and with activity of the nervous system. It is generally accepted that ageing affects kidney function as well as autonomic nervous system and hormonal balance. Given that hypertension is more prevalent in men than women until women reach their seventh decade, we hypothesised that females would be relatively protected from adverse effects of ageing compared to males and that this would be mediated by the protective effect of ovarian steroids. Intact and gonadectomised male and female normotensive Wistar rats aged 6, 12 and 18 months were used to study renal function, blood pressure, heart rate, and blood pressure variability. We observed that intact females had lower levels of proteinuria and higher (12.5%) creatinine clearance compared to intact males and that this difference was abolished by castration but not by ovariectomy. Ovariectomy resulted in a change by 9% in heart rate,
Introduction: The quality of life of every individual is influenced by many different factors. For women in menopause, estrogen deficiency is undoubtedly one of these factors. Estrogen deficit leads to a series of symptoms, which may affect their quality of life to some extent. In the clinical practice, it is important to have a tool to assess the quality of life that is practical and is able not only to assess the quality of life. Aim: The aim of the research was to determine whether and to what extent the symptoms of estrogen deficiency occur in women during menopause and how they affect their quality of life. Method: The survey ran from July to October 2016 in a medical facility in Zlín. The research involved 284 women aged 45-60 years who suffered from the symptoms of estrogen deficiency. The incidence and severity of symptoms were assessed using the printed form of the Czech version of the Menopause Rating Scale questionnaire. Results: The respondents reported mostly mild or no problems. ...
ovariectomy: surgical removal of the ovaries; female castration. Dictionary of Sexology Project: Dictionary of Sexology: Main Index|Main In...
Looking for 17-beta estradiol? Find out information about 17-beta estradiol. C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and... Explanation of 17-beta estradiol
This study aimed to examine radiologic microarchitectural changes in the mandibles of ovariectomized (OVX) rats through a systematic review and meta-analysis and to identify factors of the OVX rat model that influence on the bone microstructure. Eligible articles were identified by searching electronic databases, including Embase, Medline, Web of Science, and KoreaMed, for articles published from January 1966 to November 2017. Two reviewers independently performed study selection, data extraction, and quality assessment. The pooled standardized mean difference (SMD) with 95% confidence intervals was calculated using a random-effects model. Subgroup analysis and meta-regression were performed to explore the effect of potential sources on the outcomes. The reliability of the results was assessed by sensitivity analysis and publication bias. Of 1160 studies, 16 studies (120 OVX and 120 control rats) were included in the meta-analysis. Compared to the control group, the OVX rats trabecular bone volume
Hormone therapy (HT) is reported to be deficient in improving learning and memory in older postmenopausal women according to recent clinical studies; however, the reason for failure is unknown. A window of opportunity for estrogen treatment is proposed to explain this deficiency. Here, we found that facilitation of memory extinction and long-term depression by 17β-estradiol (E2) was normal in mice 1 week after ovariectomy (OVXST), but it was impaired in mice 3 months after ovariectomy (OVXLT). High-throughput sequencing revealed a decrease of miR-221-5p, which promoted cannabinoid receptor 1 (CB1) ubiquitination by upregulation of Neurl1a/b in E2-treated OVXLT mice. Blood samples from postmenopausal women aged 56-65 indicated decreases of miR-221-5p and 2-arachidonoylglycerol compared with samples from perimenopausal women aged 46-55. Replenishing of miR-221-5p or treatment with a CB1 agonist rescued the impairment of fear extinction in E2-treated OVXLT mice. The present study demonstrates ...
Translation: The null hypothesis holds that estrogen supplementation in postmenopausal women makes no difference with respect to Alzheimers onset. If this null hypothesis were true, then these are the frequencies we would have expected for the various cells of the table, given the marginal totals that appear along the right edge and the bottom of the table.. In case all this calculation and its accompanying jargon are proving a bit confusing, step back for a moment and think of it this way. On the null hypothesis, we would have expected the two categories of subjects those who received estrogen supplementation and those who did not to show approximately the same proportionate incidence of Alzheimers onset during the five-year period. And that is exactly what the calculated values of E are specifying. Thus, of the 156 subjects who did receive estrogen supplementation, we would have expected a 23.18/156=14.9% rate of onset; and for the 968 subjects who did not receive supplementation, we would ...
Although estrogens have long been thought to be protective against cardiovascular disease, this assumption has been challenged by clinical trials that failed to corroborate such protective effects of hormone replacement therapy in postmenopausal women. Umetani et al. found that the cholesterol metabolite 27-hydroxycholesterol (27HC, which is found in atherosclerotic lesions) competed with estradiol for binding to estrogen receptor α and β (ERα and ERβ), inhibited estradiol-dependent activation of transcriptional activity of the receptors, and inhibited the estradiol-dependent association of ERβ with the transcriptional coactivator SRC-1. In mice fed diets rich in cholesterol and fat, hypercholesterolemia was associated with increased vascular concentrations of 27HC, so that it reached concentrations comparable to those affecting ER function. 27HC inhibited the estradiol-dependent increase in mRNA encoding inducible and endothelial nitric oxide synthase (iNOS and eNOS) in mouse aortic ...
Atrazine (ATR) blunts the hormone-induced luteinizing hormone (LH) surge, when administered by gavage (50-100 mg/kg/day for 4 days), in ovariectomized rats. In this study, we determined if comparable doses delivered either by gavage (bolus dose) or distributed in diet would reduce the LH surge and subsequently affect fertility in the intact female rat. ATR was administered daily to intact female Sprague-Dawley (SD) or Long Evans (LE) rats by gavage (0, 0.75 1.5, 3, 6, 10, 12, 50, or 100 mg/kg/day) or diet (0, 30, 100, 160, 500, 660, or 1460 ppm) during one complete 4-day estrous cycle, starting on day of estrus. Estrous status, corpora lutea, ova, and LH plasma concentrations were evaluated. A second cohort of animals was mated on the fourth treatment day. Fertility metrics were assessed on gestational day 20. A higher portion of LE rats had asynchronous estrous cycles when compared to SD rats both during pretreatment and in response to ATR (≥50 mg/kg). In contrast, bolus doses of ATR (≥50 mg/kg)
ABSTRACT Objective: Staphylococcus aureus infections remain associated with considerable morbidity and mortality in both hospitals and the community. There is little information regarding the role of ovarian hormones in infections caused by S. aureus. The aim of this study was to evaluate the effects of ovariectomy in the immune response induced by S. aureus. Methods: Female mice BALB/c were ovariectomized (OVX) to significantly reduce the level of ovarian hormones. We also used sham-operated animals. The mice were inoculated intraperitoneally with S. aureus. Blood samples were collected for leukocyte count and bacterial quantification. The uterus and spleen were removed and weighed to calculate the uterine and splenic indexes. Lungs were removed and fractionated for immunohistochemical analysis for macrophage detection (anti-CD68) and relative gene expression of IL-6, IL-1β and TNF-α by RT-PCR. Results: Ovariectomy enlarged spleen size and generally increased circulating lymphocytes. OVX ...
In Vivo Studies. Systemic inflammation and mortality were induced by intraperitoneal injection of Escherichia coli endotoxin [lipopolysaccharide (LPS)] into wild-type and PARP-1-deficient mice (Liaudet et al., 2000). To induce systemic inflammatory mediator production without mortality, LPS was injected at a dose of 1 mg/kg, followed by the measurement of TNF-α and macrophage inflammatory protein (MIP)-1α at 90 min, using enzyme-linked immunosorbent assay. To inhibit the catalytic activity of PARP in vivo, the phenanthridinone-based PARP inhibitor PJ34 (Jagtap et al., 2002) at 10 mg/kg or INO-1001 (Szabó et al., 2004; Jagtap et al., 2005) at 3 mg/kg were given i.p., as a 30-min pretreatment prior to the injection of LPS.. In some experiments, LPS (1 mg/kg i.p.) was given to ovariectomized female mice in the absence or presence of PARP inhibitor pretreatment (doses as above), followed by measurement of TNF at 90 min. In another set of experiments (in female mice), the dose of LPS was increased ...
Question - What is the treatment for clitoral atrophy caused due to estrogen deficiency?. Ask a Doctor about diagnosis, treatment and medication for Estrogen deficiency, Ask an OBGYN, Gynecologic Oncology
Female subjects must be postmenopausal. Menopause can be assumed to have occurred in a woman when there is either appropriate medical documentation of prior complete bilateral oophorectomy or permanent cessation of previously occurring menses , 12 months as a result of ovarian failure or bilateral oophorectomy with documentation of hormonal deficiency by a certified healthcare ...
Female subjects must be postmenopausal. Menopause can be assumed to have occurred in a woman when there is either appropriate medical documentation of prior complete bilateral oophorectomy or permanent cessation of previously occurring menses , 12 months as a result of ovarian failure or bilateral oophorectomy with documentation of hormonal deficiency by a certified healthcare ...
Flavia de Oliveira, Laura B.M. Maifrino, Gustavo P.P. de Jesus, Juliana G. Carvalho, Cláudia Marchon and Daniel A. Ribeiro). Estrogen deprivation in postmenopausal women increases cardiovascular risk. Cardiovascular risk as a result of atherosclerosis is able to induce an inflammatory disease as far as cyclooxygenase-2 (COX-2) expression. The purpose of the study was to investigate the role of COX-2 on exercise training in female mice LDL-KO with or without ovariectomy. Results showed that ovariectomy induced a strong immunoexpression in atherosclerosis lesion of LDL-KO mice. Nevertheless, a down-regulation of COX-2 expression was detected in LDL-KO trained ovariectomized when compared to LDL-KO sedentary. Our results are consistent with the notion that exercise training is able to modulate COX-2 expression in LDL-KO mice as a result of COX-2 down-regulation.. ...
Using a kinome-wide siRNA screen, we identified the InsR/IGF-IR pathway as a mechanism of escape from hormone dependence in ER+ breast cancer. RNAi-mediated knockdown of InsR and/or IGF-IR inhibited growth of ER+ breast cancer cells adapted to hormone deprivation, but dual knockdown additively suppressed PI3K/AKT signaling. Pharmacologic blockade of InsR/IGF-IR with OSI-906 inhibited PI3K/AKT and LTED cell growth. OSI-906 also prevented the emergence of hormone-independent tumors, and suppressed growth of ER+ xenografts in ovariectomized mice. Blockade of IGF-IR alone was insufficient to prevent emergence of hormone-independent cells or suppress tumor growth, suggesting that dual inhibition of InsR and IGF-IR is necessary to prevent escape of ER+ breast cancer cells from estrogen dependence. Combined inhibition of ER and InsR/IGF-IR suppressed hormone-independent tumor growth more effectively than each intervention alone. Finally, an insulin/IGF-I-induced gene expression signature was predictive ...
Dr Kai Chen is currently a Research Associate at the School of Molecular Sciences, UWA. He finished his medical and orthopaedic surgery training in China (2007 - 2015). He completed his PhD studies (2019) in Bone Biology under the supervision of Prof.Jiake Xu at UWA.. His current research interests focus on the pathogenesis of bone disorder such as ageing- and estrogen deficiency-induced osteoporosis. To achieve this, he recently developed a first-in-kind protocol to process bone samples for isotopic imaging at the nanoscale resolution by using ion microscopy. By using a stable-isotope labelling tracer, this cutting-edge technology will advance the imaging of bone niche to an unprecedented resolution. Dr Chen is also passionate about developing biomaterials that can promote bone repair. ...
Sigma-Aldrich offers abstracts and full-text articles by [Andrea M Stathopoulos, Cleyde V Helena, Ruth Cristancho-Gordo, Arturo E Gonzalez-Iglesias, Richard Bertram].
I know women who decided never to take hormone replacement therapy because of these studies. Some of them have never returned to feeling as well as they did pre-menopause. Others, it doesnt seem to bother much. I suspect there is considerable individual physiological variability associated with the number of estrogen receptors and such, which probably determines how sensitive one is to estrogen depletion. But it is an individual thing, and each individual should decide for themselves whether the risk is worth it or not. Everything in life is a trade-off, after all. It is only in a culture where litigation thrives that miracle drugs like HRT, or anti-inflammatory agents (e.g., Vioxx, Celebrex, Ibuprofen etc.) are damned because they have side effects. EVERY SINGLE DRUG HAS SIDE EFFECTS. Litigation is only possible if the indiviudal abrogates his/her own personal responsibility in determining what the risk versus benefit is for each medication they are prescribed ...
When ovariectomized females were tested with allopregnanolone alone here also reduced CRF enahnced startle reaction.. In another set of experiments the researchers discovered that lactating female rats with high natural progesterone were markedly lower CRF-enhanced startle responses compared to virgin females with intact ovaries. The results of theses initial experiments revealed the conclusion that progesterone […]. ...
I get it: risk-reducing bilateral salpingo-oophorectomy (RRBSO) is the only proven way to protect high risk women from ovarian cancer, a disease that is particularly hard to detect, psychologically and physically devastating, and usually deadly. There are currently no accurate ways to screen for it in symptomless women and by the time symptoms do arise…
It is fairly common for ppl with allergies to have post nasal drip and an irritable choke/cough. However, one doesnt have seasonal allergy attacks Spring, Summer, Winter,and Fall, especially not for years on end. Add to the fact that anyone that is wealthy, has access to the top 1% of physicians in the world, if they were suffering from seasonal allergies to a degree such as they are presenting, she wouldve long been on a regime of allergy shots, cortisone, and she wouldve been on an antibiotic, days ago, preventing any bronchial issues turning into pneumonia. I know this, because Ive had them all my life, and Im nearly 50, and a woman. As for the hormonal/menopausal fluxes that can affect this and other health issues, shes nearly SEVENTY, ffs. Besides, I cannot think of a WORSE defense of a health issue, than suggesting estrogen depletion should be a consideration to give her a pass when her ONLY reason she has credibly given as to why anyone should ever possibly think to vote for her, is ...
The ovariectomy associated with decreased estrogen is associated with increased prevalence of obesity, a condition that increases the risk of metabolic syndrome. Evidence shows that inflammation-induced obesity in visceral adipose tissue (VAT) promotes deregulation in the expression of inflammatory cytokines. Hormone replacement (HR) and resistance training (RT) have beneficial effects on postmenopausal women, but it is unclear whether these interventions are effective in minimizing inflammation in VAT. The aim of this study was to evaluate the effects of RT and ER in adipocyte size, gene expression and protein concentration of inflammatory markers. Rats Sprague-Dowley females were divided into six groups: Sham-Sedentary (Sham-Sed), Ovariectomized Sedentary (Ovx-Sed), Sham-Trained (Sham-TR), Ovx-TR, Ovx-Sed-ER and Ovx-TR-ER. The ER was performed using Silastic® capsules. During the 12- week RT, the animals climbed a ladder with weights attached to the tails. The morphology was confirmed by ...
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This article was prepared in conjunction with a conference presentation in May 2015. It outlines new information and updates to what is known about ovarian hormone therapy.
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The brains and bodies of young female rats can be accelerated into puberty by the presence of an older male or by stimulation of the genitals.. 0 Comments. ...
On ovariectomy-induced osteoporosis". Upsala Journal of Medical Sciences. 114 (3): 140-8. doi:10.1080/03009730902891784. PMC ...
... and Flank Ovariectomy Using the Same Method for Hemostasis". Animals. 10 (12): 2223. doi:10.3390/ani10122223. Crozier, TA; ... "Comparison of intraoperative and postoperative pain during canine ovariohysterectomy and ovariectomy". The Canadian Veterinary ...
Hooper R. N.; Taylor T. S.; Varner D. D.; Blanchard T. L. (October 1993). "Effects of bilateral ovariectomy via colpotomy in ... oophorectomy or ovariectomy), which is mainly done in cats and young dogs. Another, less commonly performed method is an "ovary ...
"Effects of 3-Adrenergic Receptor Activation on Rat Urinary Bladder Hyperactivity Induced by Ovariectomy". Journal of ...
... and ovariectomy-induced obesity in mice". J. Biol. Chem. 285 (41): 31292-303. doi:10.1074/jbc.M110.147850. PMC 2951204. PMID ...
2015), the overall maturation rate after IVM of oocytes recovered from ovariectomy specimens in laboratory was 36%. The ... of oocytes recovered from ovariectomy specimens in the laboratory: a promising "ex vivo" method of oocyte cryopreservation ...
... daily injections of coumestrol were shown to reduce bone loss in rats who had undergone an ovariectomy. Coumestrol has been ...
The same year, the first ovariectomy in Boston was carried out in Carney by Henry I. Bowditch. The first Catholic nursing ...
Geusens, Piet; Dequeker, Jan; Nijs, Jos; Bramm, Erik (1990). "Effect of ovariectomy and prednisolone on bone mineral content in ...
2020-07-28). "Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 ...
J. C. Prior et al., "Premenopausal ovariectomy-related bone loss: a randomized, double-blind, one-year trial of conjugated ...
"Experimental osteoporosis induced by ovariectomy and vitamin D deficiency does not markedly affect fracture healing in rats" ( ...
Ovariectomies, surgeries inducing menopause, or natural menopause cause fluctuating and decreased estrogen levels in women. ... post ovariectomy in female rats within the hypothalamus, hippocampus, and pituitary gland. Such a change in β-EP levels could ...
This effect can be seen following ovariectomy and hormone replacement as well as under naturally occurring changes in hormone ...
Neutering in animals describes spaying or castration (also please see castration). To spay (medical term: ovariectomy or ovario ... With an ovariectomy ligatures are placed on the blood vessels above and below the ovary and the organ is removed. With an ...
Medical attempts to change homosexuality included surgical treatments such as hysterectomy, ovariectomy, clitoridectomy, ...
Bowe (November 2006). "The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in ... Bowe, James (November 15, 2012). "The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin ...
His mother was the first woman to undergo an ovariectomy, in 1809 in Danville, Kentucky to remove a tumor[citation needed]. ...
Furthermore, some methods such as ovariectomy and altered light-dark cycles have been developed to study the mechanism of ...
Regulate Bone Resorption II Adenosine A1R Blockade or Deletion Increases Bone Density and Prevents Ovariectomy-Induced Bone ...
Women who were menopausal due to ovariectomy showed significantly greater improvement in sexual function with testosterone ...
Decreased estrogen is a common cause of osteoporosis that can be seen in other conditions such as ovariectomy, ovarian failure ...
"KMUP-1 suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss: roles of MAPKs, Akt, NF-κB and ...
They established that ovariectomies reduced the incidence of mammary tumors and that tumor susceptibility varied in different ...
EEs are used in hormone therapy for menopausal symptoms, female hypogonadism, ovariectomy, and primary ovarian failure and in ...
The surgery is also called ovariectomy, but this term is mostly used in reference to animals, e.g. the surgical removal of ...
... and aromatase inhibitors like anastrozole and ovariectomy. A breast biopsy is tested for whether the cancer cells contain ...
In 1837 West published in The Lancet a description of the first ovariectomy, describing how he removed an ovarian cyst with a ... He published in 1837 the first article referred to an ovariectomy performed in England and first described the picture of a ...
... over an ethical controversy that surrounded her following her assertion that insanity could be cured through an ovariectomy ( ...
The selective CB2 agonist HU-308, but not the CB1 receptor agonist noladin ether, attenuated ovariectomy-induced bone loss and ...
ovariectomy: surgical removal of the ovaries; female castration. Dictionary of Sexology Project: Dictionary of Sexology: Main ... ovariectomy: surgical removal of the ovaries; female castration. Dictionary of Sexology Project: Main Index ...
Ovariectomy or spaying in cattle is a surgical procedure performed to avoid unwanted pregnancy of animals in areas where ... Ovariectomy in Cattle. Ovariectomy or spaying in cattle is a surgical procedure performed to avoid disease transmission and ... When ovariectomy is deemed necessary, the procedure should be performed using appropriate restraint and aseptic technique. Just ... Research leading to new or improved techniques that reduce or eliminate pain and discomfort associated with ovariectomy and ...
... Farida Hussan,1 Nawwar Ghassan Ibraheem,1 Taty Anna ... However, these ovariectomy-induced bone changes were reversed with curcumin treatment. The present study found that the bone ... Curcumin was found to induce bone changes after ovariectomy in a dose-dependent manner [20]. The dose of 110 mg/kg body weight ... 6] also mentioned that the trabecular numbers were reduced as early as the 6th week after ovariectomy in young female Sprague ...
Women are believed to be protected from non-alcoholic fatty liver disease (NAFLD) by estrogen, so postmenopausal women with lower estrogen levels have an increased chance of developing the disease. Their risk is even higher if they are on anti-estrogen therapy. Hepatic steatosis (fatty liver) is is an early stage of NAFLD which can lead to […]. View Post ...
... Ki-Shuk Shim,1 Taesoo Kim,1 ... N. Omi and I. Ezawa, "The effect of ovariectomy on bone metabolism in rats," Bone, vol. 17, no. 4, supplement, pp. 163S-168S, ...
This procedure is called an ovariectomy, or oophorectomy. Reasons for the removal of one or both ovaries include ectopic ...
The study evaluated 1,293 women with unilateral ovariectomy, 1,097 women with bilateral ovariectomy and, for comparison, 2,390 ... Ovariectomy may put younger women at risk for an earlier death. Sep 14, 2006 - 5:40:00 AM , Reviewed by: Rashmi Yadav ... We need to be very thoughtful about ovariectomy, as it may put younger women at risk for an earlier death.". Dr. Rocca says ... Half of bilateral ovariectomies are prophylactic -- done to prevent the possibility of future ovarian cancer (approximately ...
Response of ERβ and aromatase expression in the monkey hippocampal formation to ovariectomy and menopause.. Higaki S1, Takumi K ...
Stem-cell therapy for ovariectomy-induced osteoporosis in rats: a comparison of three treatment modalities. ... Methods: Osteoporosis was induced in 40 female Sprague Dawley rats by performing ovariectomy. After 12 weeks, bone marrow was ... MiR-30a-3p promotes ovariectomy-induced osteoporosis in rats via targeting SFRP1.. *. ...
... ovariectomy)-induced bone loss in mice. In conclusion, our results show that SB239063 can be a potential therapy for osteolytic ... ovariectomy)-induced bone loss in mice. In conclusion, our results showed that SB239063 can be a potential therapy for ... Ovariectomy (OVX)-Induced Osteoporosis Model. OVX-induced osteoporosis model was next established to assess the role of ... Administration of SB239063 Ameliorates Ovariectomy-Induced Bone Loss via Suppressing Osteoclastogenesis in Mice. Bao Huang1,2† ...
To describe in dogs, a technique for single port access gastropexy and ovariectomy (SPAGO) using a commercially available ... Dogs were tilted 45° in both left and right recumbency and bilateral ovariectomy performed using articulating graspers, a ... Evaluation of single port access gastropexy and ovariectomy using articulating instruments and angled telescopes in dogs. ... Single port access gastropexy and ovariectomy is a feasible procedure to provide prophylaxis against gastric dilation-volvulus ...
Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance. ... Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance ... Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance ... Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance ...
This also means anesthesia time is shorter with an ovariectomy. Is an ovariectomy less risky?. Complications are rare with both ... What are the limitations of an ovariectomy?. One important limitation of the ovariectomy is that it should only be performed in ... The ovariectomy has been practiced for decades in Europe, among other locations, with reportedly no increase in the numbers of ... Commonly performed in other countries is the ovariectomy, in which only the ovaries are removed, while the uterus is left in ...
Moody mares may benefit from ovariectomy to alter their behaviour and rideability, according to a recent report. Some mares are ... For more details, see: Moody Mares - Is Ovariectomy a Solution?. Published with the kind permission of Mark Andrews, Equine ... Owners reported that, after bilateral ovariectomy, 80 percent (8/10) of mares with normal ovaries and 57 percent (8/14) of ... The results suggest that mares with and without neoplasia can equally benefit from ovariectomy to improve behaviour and ...
Equine-Reproduction.com Bulletin Board » Breeding Problem Mares - Volume 1 » 2B uterus in mare status post ovariectomy « ...
Ovariectomy Augments Hypertension Through Rho-Kinase Activation in the Brain Stem in Female Spontaneously Hypertensive Rats. ... Ovariectomy Augments Hypertension Through Rho-Kinase Activation in the Brain Stem in Female Spontaneously Hypertensive Rats ... Ovariectomy Augments Hypertension Through Rho-Kinase Activation in the Brain Stem in Female Spontaneously Hypertensive Rats ... Ovariectomy Augments Hypertension Through Rho-Kinase Activation in the Brain Stem in Female Spontaneously Hypertensive Rats ...
Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin ...
Ovariectomy-induced depressive-like behavior and brain glucose metabolism changes in female rats are not affected by chronic ... Ovariectomy-induced depressive-like behavior and brain glucose metabolism changes in female rats are not affected by chronic ... A subset of animals was subjected to a 6-weeks CMS protocol starting 17 days after ovariectomy. Short-term estrogen depletion ... Approximately 2 and 9 weeks after estrogen depletion by ovariectomy, behavioral changes were assessed in the open-field test ...
Inactivation of autophagy ameliorates glucocorticoid-induced and ovariectomy-induced bone loss Message subject: (Your Name) has ...
Recent studies have shown that ovariectomy-induced osteoporosis in rats can be reversed by infusion of osteoblasts cultured ... Osteoporosis was induced in 40 female Sprague Dawley rats by performing ovariectomy. After 12 weeks, bone marrow was harvested ... Stem-cell therapy for ovariectomy-induced osteoporosis in rats: a comparison of three treatment modalities Mir Sadat-Ali,1 ... Keywords: osteoporosis, ovariectomy, osteoblasts, mesenchymal stem cells (MSCs), exosomes. Introduction. Osteoporosis is a ...
Ovariectomy Exacerbates and Estrogen Replacement Attenuates Photothrombotic Focal Ischemic Brain Injury in Rats. Kenji Fukuda, ... Effects of ovariectomy on cerebral blood flow of rats. Neuroendocrinology. 1998;67:260-268. ... In a study of MCA occlusion, ovariectomy (OVX) resulted in an increased infarct size in female rats, comparable to that in male ... Methods-In experiment 1, 1 week (short-term) or 4 weeks (long-term) after the ovariectomy (OVX), female SHR (5 months old) were ...
... of meloxicam proved to be a safe and effective method of controlling pain for up to 20 hours in dogs undergoing ovariectomy. ... efficacy of a preoperative administration of meloxicam in controlling postoperative pain relief in dogs undergoing ovariectomy ...
Transumbilical single incision laparoscopic left ovariectomy G Dapri Giovanni Dapri, MD, PhD, FACS, FASMBS, Hon FPALES, Hon ... This video presents a left ovariectomy performed in a patient with a symptomatic giant ovarian cyst. Clinical case: A 56-year- ...
... we presently studied the phenotype of NZM2410 lupus-prone mice following post-pubertal and pre-pubertal ovariectomy (OVX) +/- ... we presently studied the phenotype of NZM2410 lupus-prone mice following post-pubertal and pre-pubertal ovariectomy (OVX) +/- ... Early Ovariectomy Results in Reduced Numbers of CD11c+/CD11b+ Spleen Cells and Impacts Disease Expression in Murine Lupus. ... Late Ovariectomy on Survival, Body, and Organ Weights in NZM2410 Mice. NZM2410 mice underwent four different treatments: (1) no ...
Metabolomics strategy reveals the osteogenic mechanism of yak (Bos grunniens) bone collagen peptides on ovariectomy-induced ... Metabolomics strategy reveals the osteogenic mechanism of yak (Bos grunniens) bone collagen peptides on ovariectomy-induced ... results showed that YBP treatment remarkably altered the content of serum bone turnover markers and prevented the ovariectomy- ...
Objective: Ovariectomy (OVX)-induced rats are the most frequently used animal model to research postmenopausal osteoporosis. ... Bone mass improved effect of icariin for postmenopausal osteoporosis in ovariectomy-induced rats: a meta-analysis and ...
Wu, Y., Sun, Y., Ye, Y., Zhang, P., Guo, J., Huang, J., Jing, X., Xiang, W., Yu, S., Guo, F.Iguratimod prevents ovariectomy‑ ... Wu, Y., Sun, Y., Ye, Y., Zhang, P., Guo, J., Huang, J., Jing, X., Xiang, W., Yu, S., Guo, F.Iguratimod prevents ovariectomy‑ ... Wu, Y., Sun, Y., Ye, Y., Zhang, P., Guo, J., Huang, J. ... Guo, F. (2017). Iguratimod prevents ovariectomy‑induced bone loss ... Iguratimod prevents ovariectomy‑induced bone loss and suppresses osteoclastogenesis via inhibition of peroxisome proliferator‑ ...
Raspberry Ketone Reduced Lipid Accumulation in 3T3-L1 Cells and Ovariectomy-Induced Obesity in Wistar Rats by Regulating ... ovariectomy [Ovx] + RK, 352.6 ± 5 vs Ovx, 386 ± 5.8 g; P , 0.05), fat mass (Ovx + RK, 3.2 ± 0.05 vs Ovx, 5.0 ± 0.4 g; P , 0.05 ...
The effects of ovariectomy and estrogen replacement on myocardial contractility were examined in female rabbits. Ovariectomy ... and reduced isometric force compared to control and ovariectomy groups. Ovariectomy did not alter increased isometric force ... and Bay K8644-induced isometric force compared to control and ovariectomy groups. Ovariectomy increased and estrogen ... Estrogen replacement after ovariectomy (0.15 μg/kg/day i.m. 17β-estradiol acetate for 7 days) increased left ventricular mass ...
Laparoscopic ovariectomy (LapOVE) using single-portal access was attempted in 17 client-owned cats of different breeds admitted ... for elective ovariectomy. A 12 mm umbilical portal was placed 1 cm caudal to the umbilicus with the cat in dorsal recumbency. ...
  • 6 ] found a significant reduction in trabecular number and widening of trabecular spaces in the distal portion of rats' femur 6 weeks after bilateral ovariectomy. (hindawi.com)
  • RxPG] Death rates rise when women under 45 years old undergo bilateral ovariectomy -- surgical removal of both ovaries -- and do not receive proper hormone replacement therapy, according to a new Mayo Clinic study to be published in the October 1 issue of The Lancet Oncology. (rxpgnews.com)
  • To conduct this study, Dr. Rocca and colleagues followed women who had undergone unilateral or bilateral ovariectomy between 1950 and 1987 while residing in Olmsted County, Minn., home of Mayo Clinic. (rxpgnews.com)
  • Dogs were tilted 45° in both left and right recumbency and bilateral ovariectomy performed using articulating graspers, a bipolar vessel sealing device and a 30° telescope. (wiley.com)
  • Would removing both ovaries (bilateral ovariectomy) help? (horsejournals.com)
  • Owners reported that, after bilateral ovariectomy, 80 percent (8/10) of mares with normal ovaries and 57 percent (8/14) of mares with ovarian neoplasia were easier to ride. (horsejournals.com)
  • At 70-days-old OVX groups were submitted to a bilateral ovariectomy. (ovid.com)
  • The present study investigated oxidative stress induced by MetS and bilateral ovariectomy (OVX), and elucidated the mechanism underlying the protective effect of EGCG (10 umol/kg/day) on bladder overactivity. (nature.com)
  • One of the most important causes of death in women who undergo bilateral ovariectomy before reaching the normal age of menopause is cardiovascular disease (CVD) [1]. (termedia.pl)
  • In conclusion," they write, "a significant improvement was observed in rideability and behaviour post-ovariectomy, but no statistical difference in improvement after ovariectomy between mares with ovarian neoplasia and mares with histopathologic normal ovaries was observed. (horsejournals.com)
  • These changes, despite of the rise in circulating estrogen level post-ovariectomy, remained stable with age. (torlakinstitut.com)
  • In this study, thirty two female Sprague-Dawley rats were used to determine the potential effect of curcumin in prevention of bone loss following ovariectomy. (hindawi.com)
  • Methods: Osteoporosis was induced in 40 female Sprague Dawley rats by performing ovariectomy. (medworm.com)
  • To make this determination, ten month old retired female Sprague-Dawley rats were made estrogen-deficient by ovariectomy (OVAR, n = 8). (mysciencework.com)
  • Female Sprague-Dawley rats 6 months were randomly assigned to four groups of 10 each: sham ovariectomy without loading (Shm-XL), ovariectomy without loading (OVX-XL), sham ovariectomy with external loading (Shm-EL), and ovariectomy with external loading (OVX-EL). (elsevier.com)
  • The effects of ovariectomy and estrogen replacement on myocardial contractility were examined in female rabbits. (aspetjournals.org)
  • Murray, W. S. (1936) Some effects of ovariectomy during the period of declining reproductive powers in mice. (koreascience.or.kr)
  • MiR-30a-3p promotes ovariectomy-induced osteoporosis in rats via targeting SFRP1. (medworm.com)
  • Stem-cell therapy for ovariectomy-induced osteoporosis in rats: a comparison of three treatment modalities. (medworm.com)
  • Recent studies have shown that ovariectomy-induced osteoporosis in rats can be reversed by infusion of osteoblasts cultured from mesenchymal stem cells (MSCs). (dovepress.com)
  • Olive oil effectively mitigated ovariectomy-induced osteoporosis in rats, and is a promising candidate for the treatment of postmenopausal osteoporosis. (biomedcentral.com)
  • Here we examined the synergistic effect of ovariectomy (OVX) and excessive mechanical stress (forced running) on articular cartilage homeostasis in a mouse model resembling a human post menopause condition. (nii.ac.jp)
  • Hietala, E. L. (1993) The effect of ovariectomy on periosteal bone formation and bone resorption in adult rats. (koreascience.or.kr)
  • Outcome of laparoscopic ovariohysterectomy or ovariectomy in dogs with von Willebrand disease or factor VII deficiency: 20 cases (2012-2014). (semanticscholar.org)
  • OBJECTIVE To describe surgical techniques and perioperative management of dogs with von Willebrand disease (VWD) or factor VII (FVII) deficiency undergoing laparoscopic ovariohysterectomy or ovariectomy and evaluate outcomes. (elsevier.com)
  • PROCEDURES Dogs with VWD or FVII deficiency that underwent laparoscopic ovariohysterectomy or ovariectomy between 2012 and 2014 were retrospectively identified via a multi-institutional review of medical records. (elsevier.com)
  • CONCLUSIONS AND CLINICAL RELEVANCE Laparoscopic ovariohysterectomy or ovariectomy in dogs with VWD or FVII deficiency pretreated with desmopressin, cryoprecipitate, or plasma transfusions were not associated with clinical signs of hemorrhage, suggesting that minimally invasive ovariohysterectomy or ovariectomy may be considered in female dogs affected with these coagulopathies. (elsevier.com)
  • Comparison of surgical variables and short-term postoperative complications in healthy dogs undergoing ovariohysterectomy or ovariectomy. (semanticscholar.org)
  • Peer-reviewed summary for veterinarians of scientific literature related to the welfare implications of ovariectomy in cattle. (avma.org)
  • Comparison between two portal laparoscopy and open surgery for ovariectomy in dogs', Veterinary Research Forum , 5(3), pp. 219-223. (iranjournals.ir)
  • Ovariectomy may be performed with an open surgical incision or with laparoscopy. (dvsc.com)
  • The traditional spay has to be performed via open surgery and requires a fairly large incision, whereas an ovariectomy only requires a small incision and can even be carried out via laparoscopy (key hole surgery). (petguide.com)
  • The objectives of this study were to compare (1) the extent of thermal damage and (2) the time between the 5-mm LigaSure V (LS5) and 10-mm LigaSure Atlas (LS10) vessel sealing devices (VSD) when performing open ovariectomy in dogs. (ugent.be)
  • In conclusion, during open ovariectomy using VSD, LS10 causes significantly more thermal spread but surgical time is shorter compared with LS5. (ugent.be)
  • The results showed that YBP treatment remarkably altered the content of serum bone turnover markers and prevented the ovariectomy-induced deterioration of bone mechanical and microarchitecture characteristics. (rsc.org)
  • Estrogen supplementation prevented the ovariectomy-induced changes. (torlakinstitut.com)
  • These observations lead us to hypothesize that more androgens from adrenal cortex might gradually be converted into estrogens by extragonadal aromatase in the rats along with time after ovariectomy. (biomedcentral.com)
  • Women in whom we've discovered ovarian cancer or benign disease of the ovary will still be counseled to have it treated, including ovariectomy. (rxpgnews.com)
  • But, for women with average risk for breast and ovarian cancer where we might have considered preventive ovariectomy, the discussion will have more of an emphasis on conserving the ovaries for protecting the health of the woman. (rxpgnews.com)
  • This video presents a left ovariectomy performed in a patient with a symptomatic giant ovarian cyst. (websurg.com)
  • Rats were fed with high fat high sugar (HFHS) diet to induce MetS and received ovariectomy surgery to deprive ovarian hormone. (nature.com)
  • Potential advantages of ovariectomy include a smaller incision, better viewing of the ovarian pedicle, and possibly less risk of complications associated with surgical manipulation of the uterus. (wordpress.com)
  • Laparoscopic ovariectomy using the Endo-GIA stapling device procedure without coagulation may diminish ovary injury before ovarian cryopreservation. (biomedcentral.com)
  • Commonly performed in other countries is the ovariectomy, in which only the ovaries are removed, while the uterus is left in the belly. (pethealthnetwork.com)
  • The ovariectomy has been practiced for decades in Europe, among other locations, with reportedly no increase in the numbers of patients with future diseases of the uterus. (pethealthnetwork.com)
  • One important limitation of the ovariectomy is that it should only be performed in young, healthy females with a healthy uterus. (pethealthnetwork.com)
  • The ovariectomy procedure is standard practice in most European countries and it has recently been shown that there is no reason to remove the uterus unless problems with the uterus have been identified. (midsussexvets.co.uk)
  • An Ovariectomy involves surgical removal of just the ovaries, and leaves the uterus in place. (rightpet.com)
  • Alternatively, and equally effective, is the surgical removal of both ovaries (ovariectomy) without removing the uterus. (dvsc.com)
  • The biggest technical difference of a traditional ovariohysterectomy (OVH) and a laparoscopic ovariectomy is that in the latter only the ovaries are removed and the uterus is left in place. (parkwayvet.com)
  • Although a dog that has had an ovariectomy still retains her uterus, no dogs that've had this kind of spay surgery have ever been reported to have pyometra, which suggests it's caused by hormones or something else to do with the ovaries. (petguide.com)
  • The article is titled, "Ovariohysterectomy Versus Ovariectomy for Elective Sterilization of Female Dogs and Cats: Is Removal of the Uterus Necessary? (wordpress.com)
  • Ovariohysterectomy versus ovariectomy, is removal of the uterus necessary? (furfarmandfork.com)
  • An ovariectomy differs from an ovariohysterectomy in that only the ovaries are removed, leaving the uterus in place. (mercola.com)
  • Laparoscopic ovariectomy is a less invasive procedure than open abdominal surgery, and it involves removing only the ovaries, leaving the uterus in place. (mercola.com)
  • Ovariectomy or 'spaying' in cattle is a surgical procedure performed to avoid disease transmission and unwanted pregnancy of animals in areas where females cannot be segregated from males and where extensive grazing conditions prohibit control of estrus through feed additives. (avma.org)
  • When ovariectomy is deemed necessary, the procedure should be performed using appropriate restraint and aseptic technique. (avma.org)
  • This procedure is called an ovariectomy, or oophorectomy. (blausen.com)
  • Single port access gastropexy and ovariectomy is a feasible procedure to provide prophylaxis against gastric dilation-volvulus and a simultaneous means of sterilization in female dogs. (wiley.com)
  • Ovariectomy is less complicated, less time consuming and produces less morbidity than ovariohysterectomy and is therefore the procedure of choice for gonadectomy in the healthy bitch. (vetstream.com)
  • Ovariectomy (OVE) is a routine surgical procedure for neutering in small animal practice. (iranjournals.ir)
  • An Ovariectomy (OVE) is a new procedure for neutering (spaying) a female cat or dog. (rightpet.com)
  • Laparoscopic ovariectomy is a minimally invasive surgical procedure to remove both ovaries. (dvsc.com)
  • The key-hole ovariectomy operation is quicker, less involved and less painful than the conventional spay procedure. (ndsr.co.uk)
  • Much of the article discusses the benefits gained from the simplicity of the ovariectomy procedure. (furfarmandfork.com)
  • In addition, in vivo data proved that SB239063 also played a preventive role in both LPS (lipopolysaccharide)- and OVX (ovariectomy)-induced bone loss in mice. (frontiersin.org)
  • We tested the mechanisms by which estrogen treatment may alter the impact of a high-fat diet (HFD) when given at the time of ovariectomy (OVX) in mice. (diabetesjournals.org)
  • Since both estrogen and testosterone levels have immunomodulating effects, we presently studied the phenotype of NZM2410 lupus-prone mice following post- and prepubertal ovariectomy (OVX) ± estradiol (E2) replacement to determine the impact of hormonal status on disease expression and DC development in these mice. (frontiersin.org)
  • The absence of NOD2 reduced ovariectomy-induced bone loss in mice, and lowered the area and the activity of OCs, by impairing RANKL signaling. (bioscientifica.com)
  • Ovariectomy (OVX) in mice is a commonly accepted model reflecting the human menopause. (bioscientifica.com)
  • Estrogen receptor-{beta}-selective ligands alleviate high-fat diet- and ovariectomy-induced obesity in mice. (docphin.com)
  • This work explored for the first time the ovariectomy temporal changes induced in the hemostatic coagulation markers: prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), and fibrinogen concentration (FIB) along with uterine weight on adult female CD1 mice and Wistar rats. (umm.ac.id)
  • Ovariectomy differentially altered the PT hemostatic parameter of mice and rats indicating a non-equivalence among both species behaviour for experimental studies of blood coagulation. (umm.ac.id)
  • In summary, results show that male mice are more likely to become obese than female mice and that the protection against obesity in female mice is eliminated by ovariectomy. (biomedcentral.com)
  • Adrenal corticosterone in c mice following ovariectomy. (jax.org)
  • and Kaiser, I, "Adrenal corticosterone in c mice following ovariectomy. (jax.org)
  • The aim of this case series was to describe a novel technique of single-incision laparoscopic ovariectomy in dogs using the SILS Port (Covidien), a single-port multiple-access device, in 40 client-owned dogs. (semanticscholar.org)
  • A 'keyhole spay', or a 'laparoscopic ovariectomy' to use the technical term, is an alternative to traditional spaying (ovariohysterectomy) in dogs. (midsussexvets.co.uk)
  • The laparoscopic assisted incisional gastropexy was performed after ovariectomy at the multitrocar port insertion site by grasping the antral portion of the stomach with a 10 mm DuVall forceps and suturing the seromuscular layer of the antral region of the stomach to the transversus abdominis muscle. (wiley.com)
  • Laparoscopic ovariectomy was performed in 9 dogs with VWD and 2 dogs with FVII deficiency, laparoscopic ovariectomy with gastropexy was performed in 6 dogs with VWD and 1 dog with FVII deficiency, and laparoscopic-assisted ovariohysterectomy was performed in 1 dog with VWD and 1 dog with FVII deficiency. (elsevier.com)
  • Response of ERβ and aromatase expression in the monkey hippocampal formation to ovariectomy and menopause. (nih.gov)
  • In these studies, we define the mechanisms by which estrogen treatment at the time of surgical menopause (ovariectomy [OVX]) might improve the regulation of glucose and triglyceride metabolism. (diabetesjournals.org)
  • Under such background, we have supplemented Ovariectomized (OVX) - rats with olive oil four weeks before ovariectomy with an aim to evaluate the efficacy of olive oil supplementation starting before menopause. (biomedcentral.com)
  • We sought to determine whether a high-fat diet (HFD) can augment ovariectomy -induced bone resorption in a rat model of menopause possibly via the upregulation of the inflammatory biomarkers and dyslipidemia . (bvsalud.org)
  • Additionally, thanks to our veterinary counterpart in Europe where ovariectomy surgery (ovary removal only) has been performed since the early 1980's, we know that there is virtually no increase risk of the uterine disease if the ovaries are removed properly. (parkwayvet.com)
  • Methods: Forty rats were bilaterally ovariectomized and 40 were submitted to sham ovariectomy. (bvsalud.org)
  • It was demonstrated that iguratimod may prevent ovariectomy‑induced bone loss by suppressing osteoclast activity in vivo. (spandidos-publications.com)
  • In this study, we aim to demonstrate the capacity of recombinant NELL-1 to prevent ovariectomy (OVX)-induced osteoporosis in a senile rat model. (elsevier.com)
  • Continuing preventive ovariectomies in average-risk younger women and emphasizing estrogen replacement therapy thereafter may not be an adequate solution to diminish the risk, however, as compliance is poor for taking estrogen replacement therapy, says Dr. Gostout. (rxpgnews.com)
  • Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured mouse calvariae. (jci.org)
  • Estrogen replacement after ovariectomy (0.15 μg/kg/day i.m. 17β-estradiol acetate for 7 days) increased left ventricular mass and papillary muscle mass, and reduced isometric force compared to control and ovariectomy groups. (aspetjournals.org)
  • Estrogen replacement increased the ED 50 for isoproterenol- and Bay K8644-induced isometric force compared to control and ovariectomy groups. (aspetjournals.org)
  • Ovariectomy increased and estrogen replacement decreased isometric force associated with increased Ca ++ o . (aspetjournals.org)
  • Estrogen replacement reduced the number, but not the dissociation constant for 3 H-nitrendipine binding in plasma membrane preparations (compared to ovariectomy and control groups). (aspetjournals.org)
  • abstract = "Background: The circulating estrogen concentration elevated gradually along with time after ovariectomy in rats. (houstonmethodist.org)
  • abstract = "Experiments were designed to determine how ovariectomy modulates mitogenic factors in platelets and how these factors affect proliferation of coronary arterial smooth muscle. (elsevier.com)
  • We evaluated the pharmacological effect of ER-ß-selective ligands (ß-LGNDs) in animal models of high-fat diet- and ovariectomy-induced obesity. (docphin.com)
  • Cholecalciferol was administered to the ovariectomized (OVX) rats and OVX rats treated with low dose of 17β-estradiol (17β-E2, 0.5 μg/rat, SC once daily, for 14 days) after long-term ovariectomy. (operamedphys.org)
  • We do not believe that there is any scientific evidence for the preferential teaching of ovariohysterectomy instead of ovariectomy by schools and colleges of veterinary medicine in the United States and Canada, and it is our view that ovariectomy provides an equally effective technique for elective sterilization of female dogs and cats with no recognized disadvantages. (wordpress.com)
  • The main benefit of having an ovariectomy, over a traditional ovariohysterectomy, is that the surgery is generally quicker, potentially safer, and may cause less discomfort after the fact. (petguide.com)
  • To describe in dogs, a technique for single port access gastropexy and ovariectomy (SPAGO) using a commercially available multitrocar port and to evaluate short-term outcome. (wiley.com)
  • The aim of this prospective, double-blinded, randomised study was to assess the efficacy of a preoperative administration of meloxicam in controlling postoperative pain relief in dogs undergoing ovariectomy. (vin.com)
  • Finally, preoperative administration of meloxicam proved to be a safe and effective method of controlling pain for up to 20 hours in dogs undergoing ovariectomy. (vin.com)
  • Laparoscopic ovariectomy in dogs using a single-port multiple-access device. (semanticscholar.org)
  • Evaluation of the learning curve for a board-certified veterinary surgeon performing laparoendoscopic single-site ovariectomy in dogs. (semanticscholar.org)
  • Laparoscopic ovariectomy may be performed at the same time as elective Laparoscopic Gastropexy to prevent Gastric Dilatation- Volvulous (GDV) syndrome in high-risk breeds of dogs. (dvsc.com)
  • Treatment of these cases is likely to involve removing the affected ovary (ovariectomy). (horsejournals.com)
  • Ovariectomy reduced the expression of sexual behaviours, although a significant proportion of females still courted the male 14 days after the ovary removal. (royalsocietypublishing.org)
  • Recovery from laparoscopic-assisted ovariectomy is relatively short. (dvsc.com)
  • Laparoscopic ovariectomy (LapOVE) using single-portal access was attempted in 17 client-owned cats of different breeds admitted for elective ovariectomy. (bmj.com)
  • Fourteen mixed-breed domestic cats underwent laparoscopic ovariectomy (lapOVE) using pediatric equipment, a Nd:YAG laser and a bipolar electrocoagulation forceps. (uu.nl)
  • The article goes on to describe how an ovariectomy is (logically) less invasive and faster than an ovariohysterectomy 1 . (pethealthnetwork.com)
  • According to reports comparing the two techniques, it was found that ovariectomy is less invasive and eliminates the risk of ureter ligation at the uterine body. (mercola.com)
  • Ovariectomy is a viable alternative to ovariohysterectomy Ovariohysterectomy in the dog and cat and has been practised in Europe since 1981. (vetstream.com)
  • The data on this has been published in 'Veterinary Surgery' and the conclusion is that ovariectomy is the preferred method of sterilisation in the dog. (midsussexvets.co.uk)
  • Call multiple veterinary hospitals in your community and ask if the vets on staff are willing to perform ovariectomies (if the receptionist is uncertain about what you are asking, you may wish to tactfully ask to speak with a veterinarian or technician). (wordpress.com)
  • Ovariectomy fails to modify the cardiac myosin isoenzyme profile of adult rats. (mysciencework.com)
  • These data demonstrate that myosin isoenzyme distribution in the adult heart is unaltered by ovariectomy, suggesting that estrogen loses its ability to regulate expression of this protein in the mature heart. (mysciencework.com)
  • The study investigated the influence of peripubertal ovariectomy on the thymic noradrenaline (NA) concentration, and the thymocyte NA content and beta(2)- and alpha(1)-adrenoceptor (AR) expression in adult 2- and 11-month-old rats. (torlakinstitut.com)
  • The structure and function of C cells of adult female rats after ovariectomy (Ovx) were investigated. (ac.rs)
  • The aim of the study was to examine the effects of chronic cholecalciferol administration (1.0, 2.5 or 5.0 mg/kg/day, SC once daily, for 14 days) on depression-like behavior following long-term ovariectomy (12 weeks) of the adult (3 months old) female rats of Wistar line. (operamedphys.org)
  • Following long-term ovariectomy in the adult female rats, cholecalciferol at dose of 1.0 mg/kg/day administered alone resulted in decrease of depression-like behavior in the FST. (operamedphys.org)
  • Additionally, ovariectomy diminished the average thymocyte surface density of beta(2)-ARs, but it increased that of alpha(1)-ARs in 2-month-old-rats (due to estrogen, and estrogen and progesterone deficiency, respectively). (torlakinstitut.com)
  • The aim of this study was to evaluate the effects of pentoxifylline (PTX) and alendronate (ALN), on the stereological parameters, and gene expression in callus of fracture in an experimental rat model of ovariectomy-induced osteoporosis (OVX). (iranjournals.ir)
  • Ovariectomy for Moody Mares? (horsejournals.com)
  • Moody mares may benefit from ovariectomy to alter their behaviour and rideability, according to a recent report. (horsejournals.com)
  • They suggest that, despite the significant improvement observed in the present study, further research is necessary to confirm whether mares with unwanted behaviour not obviously related to the oestrus cycle and to painful conditions may benefit from ovariectomy to alter their behaviour and rideability. (horsejournals.com)
  • The results suggest that mares with and without neoplasia can equally benefit from ovariectomy to improve behaviour and rideability. (horsejournals.com)
  • Moody Mares - Is Ovariectomy a Solution? (horsejournals.com)
  • Methods -In experiment 1, 1 week (short-term) or 4 weeks (long-term) after the ovariectomy (OVX), female SHR (5 months old) were randomly subjected to photothrombotic occlusion of the middle cerebral artery, and the infarct volumes were determined. (ahajournals.org)
  • In a study of MCA occlusion, ovariectomy (OVX) resulted in an increased infarct size in female rats, comparable to that in male rats. (ahajournals.org)
  • Drug-induced prevention of gastrectomy- and ovariectomy-induced osteopaenia in the young female rat. (chalmers.se)