Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)
A smooth, solid or cystic fibroepithelial (FIBROEPITHELIAL NEOPLASMS) tumor, usually found in the OVARIES but can also be found in the adnexal region and the KIDNEYS. It consists of a fibrous stroma with nests of epithelial cells that sometimes resemble the transitional cells lining the urinary bladder. Brenner tumors generally are benign and asymptomatic. Malignant Brenner tumors have been reported.
A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
A sex cord-gonadal stromal tumor consists of LEYDIG CELLS; SERTOLI CELLS; and FIBROBLASTS in varying proportions and degree of differentiation. Most such tumors produce ANDROGENS in the Leydig cells, formerly known as androblastoma or arrhenoblastoma. Androblastomas occur in the TESTIS or the OVARY causing precocious masculinization in the males, and defeminization, or virilization (VIRILISM) in the females. In some cases, the Sertoli cells produce ESTROGENS.
A gonadal stromal neoplasm composed only of THECA CELLS, occurring mostly in the postmenopausal OVARY. It is filled with lipid-containing spindle cells and produces ESTROGENS that can lead to ENDOMETRIAL HYPERPLASIA; UTERINE HEMORRHAGE; or other malignancies in postmenopausal women and sexual precocity in girls. When tumors containing theca cells also contain FIBROBLASTS, they are identified as thecoma-fibroma tumors with less active hormone production.
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646)
Gonadal neoplasm composed entirely of SERTOLI CELLS or may have a component of GRANULOSA CELLS. Some of the Sertoli cell tumors produce ESTROGEN or ANDROGENS, but seldom in sufficient quantity to cause clinical symptoms such as FEMINIZATION or masculinization (VIRILISM).
General term for CYSTS and cystic diseases of the OVARY.
A tumor consisting of displaced ectodermal structures along the lines of embryonic fusion, the wall being formed of epithelium-lined connective tissue, including skin appendages, and containing keratin, sebum, and hair. (Stedman, 25th ed)
Pathological processes of the OVARY.
Neoplasms derived from the primitive sex cord or gonadal stromal cells of the embryonic GONADS. They are classified by their presumed histogenesis and differentiation. From the sex cord, there are SERTOLI CELL TUMOR and GRANULOSA CELL TUMOR; from the gonadal stroma, LEYDIG CELL TUMOR and THECOMA. These tumors may be identified in either the OVARY or the TESTIS.
A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)
A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A malignant epithelial tumor with a glandular organization.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Neoplasms containing cyst-like formations or producing mucin or serum.
Tumors or cancer of the SKIN.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Tumors or cancers of the KIDNEY.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Tumors or cancer of the THYROID GLAND.
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
DNA present in neoplastic tissue.
Tumors or cancer of the LUNG.
Tumors or cancer of the PAROTID GLAND.
Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.
Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.
Tumors or cancer of the APPENDIX.
Tumors or cancer of the LIVER.
A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.
Tumors or cancer of the ENDOCRINE GLANDS.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.
Tumors or cancer of the EYE.
Tumors or cancer of the NOSE.
Tumors or cancer of the SALIVARY GLANDS.
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.
Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
A benign epithelial tumor with a glandular organization.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Tumors or cancer of the UTERUS.
Tumors or cancer of the INTESTINES.
Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.
Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.
A general term for various neoplastic diseases of the lymphoid tissue.
Tumors or cancer located in bone tissue or specific BONES.
Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.
Neoplasms composed of more than one type of neoplastic tissue.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Tumors or cancer of the MANDIBLE.
Tumors or cancer of the BILE DUCTS.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the THYMUS GLAND.
Tumors or cancer of the SPLEEN.
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.

An improved method for the structural profiling of keratan sulfates: analysis of keratan sulfates from brain and ovarian tumors. (1/9962)

A previously developed method for the structural fingerprinting of keratan sulfates (Brown et al., Glycobiology, 5, 311-317, 1995) has been adapted for use with oligosaccharides fluorescently labeled with 2-aminobenzoic acid following keratanase II digestion. The oligosaccharides are separated by high-pH anion-exchange chromatography on a Dionex AS4A-SC column. This methodology permits quantitative analysis of labeled oligosaccharides which can be detected at the sub-nanogram ( approximately 100 fmol) level. Satisfactory calibration of this method can be achieved using commercial keratan sulfate standards. Keratan sulfates from porcine brain phosphocan and human ovarian tumors have been examined using this methodology, and their structural features are discussed.  (+info)

Role of dexamethasone dosage in combination with 5-HT3 antagonists for prophylaxis of acute chemotherapy-induced nausea and vomiting. (2/9962)

Dexamethasone (20 mg) or its equivalent in combination with 5-HT3 antagonists appears to be the gold-standard dose for antiemetic prophylaxis. Additional to concerns about the use of corticosteroids with respect to enhanced tumour growth or impaired killing of the tumour cells, there is evidence that high-dosage dexamethasone impairs the control of delayed nausea and emesis, whereas lower doses appear more beneficial. To come closer to the most adequate dose, we started a prospective, single-blind, randomized trial investigating additional dosage of 8 or 20 mg dexamethasone to tropisetron (Navoban), a 5-HT3 receptor antagonist, in cis-platinum-containing chemotherapy. After an interim analysis of 121 courses of chemotherapy in 69 patients, we have been unable to detect major differences between both treatment alternatives. High-dose dexamethasone (20 mg) had no advantage over medium-dose dexamethasone with respect to objective and subjective parameters of acute and delayed nausea and vomiting. In relation to concerns about the use of corticosteroids in non-haematological cancer chemotherapy, we suggest that 8 mg or its equivalent should be used in combination with 5-HT3 antagonists until further research proves otherwise.  (+info)

Cancer risk in close relatives of women with early-onset breast cancer--a population-based incidence study. (3/9962)

Inherited susceptibility to breast cancer is associated with an early onset and bilateral disease. The extent of familial risks has not, however, been fully assessed in population-based incidence studies. The purpose of the study was to quantify the risks for cancers of the breast, ovary and other sites of close relatives of women in whom breast cancer was diagnosed at an early age. Records collected between 1943 and 1990 at the Danish Cancer Registry were searched, and 2860 women were found in whom breast cancer was diagnosed before age 40. Population registers and parish records were used to identify 14 973 parents, siblings and offspring of these women. Cancer occurrence through to 31 December 1993 was determined within the Cancer Registry's files and compared with national incidence rates. Women with early-onset breast cancer were at a nearly fourfold increased risk of developing a new cancer later in life (268 observed vs. 68.9 expected). The excess risk was most evident for second cancer of the breast (181 vs. 24.5) and for ovarian cancer (20 vs. 3.3). For mothers and sisters, risks for cancers of the breast and ovary were significantly increased by two- to threefold. Bilateral breast cancer and breast-ovarian cancer were very strong predictors of familial risks, with one in four female relatives predicted to develop breast and/or ovarian cancer by age 75. Mothers had a slightly increased risk of colon cancer, but not endometrial cancer. The risk for breast cancer was also increased among fathers (standardized incidence ratio 2.5; 95% CI 0.5-7.4) and especially brothers (29; 7.7-74), although based on small numbers. The risk for prostatic cancer was unremarkable. In this large population-based survey, the first-degree relatives of women who developed breast cancer before age 40 were prone to ovarian cancer as well as male and female breast cancer, but not other tumours that may share susceptibility genes with breast cancer.  (+info)

Frequent silencing of the GPC3 gene in ovarian cancer cell lines. (4/9962)

GPC3 encodes a glypican integral membrane protein and is mutated in the Simpson-Golabi-Behmel syndrome. Simpson-Golabi-Behmel syndrome, an X-linked condition, is characterized by pre- and postnatal overgrowth as well as by various other abnormalities, including increased risk of embryonal tumors. The GPC3 gene is located at Xq26, a region frequently deleted in advanced ovarian cancers. To determine whether GPC3 is a tumor suppressor in ovarian neoplasia, we studied its expression and mutational status in 13 ovarian cancer cell lines. No mutations were found in GPC3, but its expression was lost in four (31%) of the cell lines analyzed. In an of the cases where GPC3 expression was lost, the GPC3 promoter was hypermethylated, as demonstrated by Southern analysis. Expression of GPC3 was restored by treatment of the cells with the demethylating agent 5-aza-2'-deoxycytidine. A colony-forming assay confirmed that ectopic GPC3 expression inhibited the growth of ovarian cancer cell lines. Our results show that GPC3, a gene involved in the control of organ growth, is frequently inactivated in a subset of ovarian cancers and suggest that it may function as a tumor suppressor in the ovary.  (+info)

Survival in familial, BRCA1-associated, and BRCA2-associated epithelial ovarian cancer. United Kingdom Coordinating Committee for Cancer Research (UKCCCR) Familial Ovarian Cancer Study Group. (5/9962)

The natural history of hereditary and BRCA1- and BRCA2-associated epithelial ovarian cancer may differ from that of sporadic disease. The purpose of this study was to compare the clinical characteristics of BRCA1- and BRCA2-associated hereditary ovarian cancer, hereditary ovarian cancer with no identified BRCA1/2 mutation, and ovarian cancer in population-based controls. BRCA1 and BRCA2 mutation testing was carried out on index cases from 119 families with site-specific epithelial ovarian cancer or breast-ovarian cancer. We estimated overall survival in 151 patients from 57 BRCA1 and BRCA2 mutation families and compared it with that in 119 patients from 62 families in which a BRCA1/2 mutation was not identified. We compared clinical outcome and data on tumor histopathology, grade, and stage. We also compared survival in familial epithelial ovarian cancer, whether or not a mutation was identified, with that of an age-matched set of population control cases. Overall survival at 5 years was 21% (95% confidence interval, 14-28) in cases from BRCA1 mutation families, 25% (8-42) in BRCA2 mutation families, and 19% (12-26) in families with no identified mutation (P = 0.91). Survival in familial ovarian cancer cases as a whole was significantly worse than for population controls (P = 0.005). In the familial cases, we found no differences in histopathological type, grade, or stage according to mutation status. Compared to population control cases, mucinous tumors occurred less frequently in the familial cases (2 versus 12%, P<0.001), and a greater proportion of the familial cases presented with advanced disease (83% stage III/IV versus 56%; P = 0.001). We have shown that survival in familial ovarian cancer cases is worse than that in sporadic cases, whether or not a BRCA1/2 mutation was identified, perhaps reflecting a difference in biology analogous to that observed in breast cancer.  (+info)

Survival after breast cancer in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers. (6/9962)

BACKGROUND: Studies of survival following breast and ovarian cancers in BRCA1 and/or BRCA2 mutation carriers have yielded conflicting results. We undertook an analysis of a community-based study of Ashkenazi Jews to investigate the effect of three founder mutations in BRCA1 and BRCA2 on survival among patients with breast or ovarian cancer. METHODS: We collected blood samples and questionnaire data from 5318 Ashkenazi Jewish volunteers. The blood samples were tested for 185delAG (two nucleotide deletion) and 5382insC (single nucleotide insertion) mutations in BRCA1 and the 6174delT (single nucleotide deletion) mutation in BRCA2. To estimate survival differences in the affected relatives according to their BRCA1 and/or BRCA2 mutation carrier status, we devised and applied a novel extension of the kin-cohort method. RESULTS: Fifty mutation carriers reported that 58 of their first-degree relatives had been diagnosed with breast cancer and 10 with ovarian cancer; 907 noncarriers reported 979 first-degree relatives with breast cancer and 116 with ovarian cancer. Kaplan-Meier estimates of median survival after breast cancer were 16 years (95% confidence interval [CI] = 11-40) in the relatives of carriers and 18 years (95% CI = 15-22) in the relatives of noncarriers, a difference that was not statistically significant (two-sided P = .87). There was also no difference in survival times among the 126 first-degree relatives with ovarian cancer. We found no survival difference between patients with breast or ovarian cancer who were inferred carriers of BRCA1 and/or BRCA2 mutations and noncarriers. CONCLUSIONS: Carriers of BRCA1 and BRCA2 mutations appeared to have neither better nor worse survival prognosis.  (+info)

In vivo localization of [(111)In]-DTPA-D-Phe1-octreotide to human ovarian tumor xenografts induced to express the somatostatin receptor subtype 2 using an adenoviral vector. (7/9962)

Adenoviral vectors, encoding genes for cell surface antigens or receptors, have been used to induce their high level expression on tumor cells in vitro and in vivo. These induced antigens and receptors can then be targeted with radiolabeled antibodies or peptides for potential radiotherapeutic applications. The purpose of this study was to determine a dosing schema of an adenoviral vector encoding the human somatostatin receptor subtype 2 (AdCMVhSSTr2) for achieving the highest tumor localization of [(111)In]-DTPA-D-Phe1-octreotide, which binds to this receptor, in a human ovarian cancer model as a prelude to future therapy studies. AdCMVhSSTr2 was produced and used to induce hSSTr2 on A427 human nonsmall cell lung cancer cells and on SKOV3.ipl human ovarian cancer cells in vitro, as demonstrated by competitive binding assays using [125I]-Tyr1-somatostatin and [(111)In]-DTPA-D-Phe1-octreotide. Mice bearing i.p. SKOV3.ip1 tumors administered 1 x 10(9) plaque-forming units of AdCMVhSSTr2 i.p. 5 days after tumor cell inoculation, followed by an i.p. injection of [(111)In]-DTPA-D-Phe1-octreotide 2 days later, showed a range of 15.3-60.4% median injected dose/gram (ID/g) in tumor at 4 h after injection compared with 3.5% ID/g when [125I]-Tyr1-somatostatin was administered and 0.3% ID/g when the negative control peptide [125I]-mIP-bombesin was administered. Mice administered a control adenoviral vector encoding the gastrin-releasing peptide receptor did not have tumor localization of [(111)In]-DTPA-D-Phe1-octreotide (<1.6% ID/g), demonstrating specificity of [(111)In]-DTPA-D-Phe1-octreotide for the AdCMVhSSTr2 induced tumor cells. In another set of experiments, the tumor localization of [(111)In]-DTPA-D-Phe1-octreotide was not different 1, 2, or 4 days after AdCMVhSSTr2 injection (31.8, 37.7, and 40.7% ID/g, respectively; P = 0.88), indicating that multiple injections of radiolabeled peptide can be administered with equivalent uptake over a 4-day period. [(111)In]-DTPA-D-Phe1-octreotide tumor localization in animals administered AdCMVhSSTr2 on consecutive days or 2 days apart was 22.4% ID/g and 53.2% ID/g, respectively (P = 0.009) when [(111)In]-DTPA-D-Phe1-octreotide was given 1 day after the second AdCMVhSSTr2 injection. There was no difference in [(111)In]-DTPA-D-Phe1-octreotide localization after a single AdCMVhSSTr2 injection (40.7% ID/g) or two injections of AdCMVhSSTr2 given 1 (45.9% ID/g) or 2 (53.2% ID/g) days apart, where [(111)In]-DTPA-D-Phe1-octreotide was given in each case 4 days after the first AdCMVhSSTr2 injection (P = 0.65). Therefore, two AdCMVhSSTr2 injections did not increase [(111)In]-DTPA-D-Phe1-octreotide tumor localization compared with one injection, which eliminates concerns about an immune response to a second dose of AdCMVhSSTr2. This will be the basis for a therapeutic protocol with multiple administrations of an octreotide analogue labeled with a therapeutic radioisotope.  (+info)

Combination of theanine with doxorubicin inhibits hepatic metastasis of M5076 ovarian sarcoma. (8/9962)

Theanine is a peculiar amino acid existing in green tea leaves, which was previously indicated to enhance the antitumor activity of doxorubicin. In the present study, the effect of combination of theanine with doxorubicin against hepatic metastasis of M5076 ovarian sarcoma was investigated. The primary tumor was significantly reduced by the combined treatment on M5076 transplanted (s.c.) mice. The liver weight of control mice increased to twice the normal level because of hepatic metastasis of M5076. In contrast, the injection of doxorubicin alone or theanine plus doxorubicin suppressed the increase in liver weight and inhibited hepatic metastasis. Moreover, the liver weights and metastasis scores demonstrated that theanine enhanced the inhibition of hepatic metastasis induced by doxorubicin. Furthermore, in vitro experiments indicated that theanine increased the intracellular concentration of doxorubicin remaining in M5076 cells. This action suggests that theanine leads the enhancement of the suppressive efficacy of doxorubicin on hepatic metastasis in vivo. Therefore, it was proved that theanine increased not only the antitumor activity on primary tumor but also the metastasis-suppressive efficacy of doxorubicin. The effect of theanine on the efficacy of antitumor agents is expected to be applicable in clinical cancer chemotherapy.  (+info)

TY - JOUR. T1 - Race/ethnic variations in ovarian cancer mortality in the United States, 1992-1997. AU - Howe, Holly L.. AU - Tung, Ko Hui. AU - Coughlin, Steven. AU - Jean-Baptiste, Rachel. AU - Hotes, Joellyn. PY - 2003/5/15. Y1 - 2003/5/15. N2 - Ovarian cancer is reported to be the most fatal malignancy of the female genital tract and the fifth leading cause of cancer deaths among women. In the current study, the authors describe ovarian cancer mortality by race and ethnicity in the U.S. during the years 1992-1997, a period comparable to the ovarian cancer incidence data presented in this supplement.. AB - Ovarian cancer is reported to be the most fatal malignancy of the female genital tract and the fifth leading cause of cancer deaths among women. In the current study, the authors describe ovarian cancer mortality by race and ethnicity in the U.S. during the years 1992-1997, a period comparable to the ovarian cancer incidence data presented in this supplement.. UR - ...
TY - JOUR. T1 - Aberrant non-canonical WNT pathway as key-driver of high-grade serous ovarian cancer development. AU - Zannoni, Gian Franco. PY - 2020. Y1 - 2020. N2 - Epithelial ovarian cancer (EOC), the deadliest among gynecologic malignancies, is ranked as the fifth leading cause of cancer deaths in females [1]. Based on morphological findings, cellular origins, clinical characteristics, and several molecular genetic/epigenetic alterations, EOC has been subdivided into five main types: high-grade serous (HGSC, 70%), endometrioid (EC, 10%), clear cell (CC, 10%), mucinous (MC, 3%), and low-grade serous carcinomas (LGSC, , 5%) that account for over 95% of cases [2]. HGSCs generally harbor TP53 alterations, a pronounced genomic instability and, also, inherited and somatic BRCA1 and BRCA2 mutations. The other abovementioned cancer types are frequently characterized by mutations in KRAS, BRAF, PTEN, and CTNNB1 (Beta-catenin), and a relatively stable karyotype [2]. In this complex and heterogeneous ...
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TY - JOUR. T1 - Adenosine triphosphate-based chemotherapy response assay predicts long-Term survival of primary epithelial ovarian cancer. AU - Li, Lan Ying. AU - Kim, Sang Wun. AU - Nam, Eun Ji. AU - Lee, Jungyun. AU - Kim, Sunghoon. AU - Kim, Young Tae. PY - 2019/2/1. Y1 - 2019/2/1. N2 - Objective The aim of this study is to analyze the long-Term relapse-free survival and overall survival outcomes of primary ovarian cancer patients using adenosine triphosphate-based chemotherapy response analysis. Methods In total, 162 primary epithelial ovarian cancer patients who underwent chemotherapy response assay for carboplatin, cisplatin, and paclitaxel by adenosine triphosphate-based chemotherapy response analysis prior to chemotherapy between December 2006 and November 2016 were retrospectively reviewed. Chemosensitivity with single or combined three agents and clinical characteristics of patients were studied to understand their correlation with long-Term relapse-free survival and overall survival. ...
While ovarian cancer remains the most lethal gynecological malignancy in the United States, there are no biomarkers available that are able to predict therapeutic responses to ovarian malignancies. OVCAR3 cells were treated with EGF1, and the time course of cell progression was monitored based on Akt phosphorylation and growth dynamics. EGF-stimulated Akt phosphorylation was detected at 12 h post-treatment, but an impact on expansion was not really noticed until 48 l post-exposure. Growth-stimulated mobile lysates had been examined for proteins single profiles between treatment organizations and across period factors using iTRAQ marking and mass spectrometry. The proteins response to EGF treatment was determined via iTRAQ evaluation in EGF-stimulated lysates relatives to vehicle-treated individuals across the treatment period program. Approval research had been performed on one of the controlled aminoacids differentially, lysosomal-associated membrane layer INK 128 proteins 1 (Light-1), in human ...
Olaparib (PARP inhibitors) - Ovarian Cancer Treatment Olaparib (PARP inhibitors) - Ovarian Cancer Treatment Olaparib (PARP inhibitors) - Ovarian Cancer
Fingerprint Dive into the research topics of Identification of underexpressed genes in early- and late-stage primary ovarian tumors by suppression subtraction hybridization. Together they form a unique fingerprint. ...
TY - JOUR. T1 - Polymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer. T2 - A report from the ovarian cancer association consortium. AU - Amankwah, Ernest K.. AU - Wang, Qinggang. AU - Schildkraut, Joellen M.. AU - Tsai, Ya Yu. AU - Ramus, Susan J.. AU - Fridley, Brooke L.. AU - Beesley, Jonathan. AU - Johnatty, Sharon E.. AU - Webb, Penelope M.. AU - Chenevix-Trench, Georgia. AU - Australian Ovarian Cancer Study Group, Ovarian Cancer Study Group. AU - Dale, Laura C.. AU - Lambrechts, Diether. AU - Amant, Frederic. AU - Despierre, Evelyn. AU - Vergote, Ignace. AU - Gayther, Simon A.. AU - Gentry-Maharaj, Aleksandra. AU - Menon, Usha. AU - Chang-Claude, Jenny. AU - Wang-Gohrke, Shan. AU - Anton-Culver, Hoda. AU - Ziogas, Argyrios. AU - Dörk, Thilo. AU - Dürst, Matthias. AU - Antonenkova, Natalia. AU - Bogdanova, Natalia. AU - Brown, Robert. AU - Flanagan, James M.. AU - Kaye, Stanley B.. AU - Paul, James. AU - Bützow, Ralf. AU - Nevanlinna, Heli. AU - Campbell, ...
Cell lines and culture. The derivation, source, and propagation of human epithelial ovarian cancer cell lines, such as cisplatin-sensitive (A2780-PAR) and platinum-resistant (A2780-CP20 and RMG2) epithelial ovarian cancer cell lines, were maintained as previously described (30). The A2780-CP20 cell line was developed by sequential exposure of the A2780 cell line to increasing concentrations of cisplatin. All experiments were done with 70% to 80% confluent cultures.. ATP7A and ATP7B gene silencing by siRNA. siRNA constructs targeted to ATP7A and ATP7B were designed and purchased from Qiagen. The target sequences were 5′-CTGGACCGGATTGTTAATTAT-3′ (for ATP7A) and 5′-CCAATTGATATTGAGCGGTTA-3′ (for ATP7B). In vitro transient transfection was done as described previously (28). Briefly, cells were transfected with ATP7A- and/or ATP7B-specific or scrambled (control) siRNA using RNAiFect reagent (Qiagen). At selected time intervals, cells were harvested to measure mRNA and protein levels of ATP7B ...
Xu, J., et al. Mass spectrometry-based peptidome profiling of human serous ovarian cancer tissues. The International Journal of Biochemistry & Cell Biology. S1357-2725(18)30258-9. 10/12/2018.. We identified 634 differentially expressed peptides, 508 of these peptides were highly abundant in serous ovarian cancer tissues, a result consistent with higher protease activity in ovarian cancer patients. The difference in preferred cleavage sites between the serous ovarian cancer tissues and normal ovarian epithelium indicates the characteristic peptidome of ovarian cancer and the nature of cancer-associated protease activity. Interestingly, KEGG pathway analysis of the peptide precursors indicated that the differentially regulated pathways in ovarian cancer are highly consistent with the pathways discovered in other cancers. Besides, we found that a proportion of the differentially expressed peptides are similar to the known immune-regulatory peptides and anti-bacterial peptides. Then we further ...
Vectors based on adenoviruses have been designed as targeted anti-cancer therapeutics that showed promising results in pre-clinical applications. In clinical trials, these oncolytic adenoviruses have generally been proved safe in patients, but have fallen short of their expected therapeutic value. In this thesis the susceptibility of primary ovarian cancer cells to oncolytic adenoviruses was studied in order to identify cellular mechanisms that confer resistance to virotherapy. Using gene expression profiling of cancer cells either resistant or susceptible to viral oncolysis, it was discovered that the epithelial phenotype of ovarian cancer represents a barrier to infection by commonly used oncolytic adenoviruses targeted to coxsackie- and adenovirus receptor (CAR) or CD46. Accessibility to viral receptors was critically linked to depolarization and the loss of tight and adherens junctions, both hallmarks of epithelial-mesenchymal transition (EMT). Importantly, tumors in situ as well as ...
We have previously demonstrated that Kruppel-like factor 8 (KLF8) participates in oncogenic transformation of mouse fibroblasts and is highly overexpressed in human ovarian cancer. In this work, we first correlated KLF8 overexpression with the aggressiveness of ovarian patient tumors and then tested if KLF8 could transform human ovarian epithelial cells. Using the immortalized non-tumorigenic human ovarian surface epithelial cell line T80 and retroviral infection, we generated cell lines that constitutively overexpress KLF8 alone or its combination with the known ovarian oncogenes c-Myc, Stat3c and/or Akt and examined the cell lines for anchorage-independent growth and tumorigenesis. The soft agar clonogenic assay showed that T80/KLF8 cells formed significantly more colonies than the mock cells. Interestingly, the cells expressing both KLF8 and c-Myc formed the largest amounts of colonies, greater than the sum of colonies formed by the cells expressing KLF8 and c-Myc alone. These results suggested that
Response to microtubule-interacting agents in primary epithelial ovarian cancer cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
DISEASE CHARACTERISTICS: Histologically confirmed stage III ovarian epithelial cancer or primary peritoneal carcinoma of one of the following cell types: Serous adenocarcinoma Mucinous adenocarcinoma Clear-cell adenocarcinoma Endometrioid Adenocarcinoma (not otherwise specified) Undifferentiated carcinoma Transitional cell Malignant Brenners tumor Mixed epithelial carcinoma No borderline tumor (tumor of low malignant potential) Underwent prior standard initial cytoreductive surgery within the past 6 weeks Optimally resected disease with no residual site of disease more than 1 cm in greatest dimension Removal of all disease extending beyond the reproductive tract Total hysterectomy and bilateral salpingo-oopherectomy at cytoreductive surgery or in the past. PATIENT CHARACTERISTICS: Age: 18 and over Performance status: GOG 0-2 Life expectancy: Not specified Hematopoietic: WBC at least 3,000/mm3 Absolute neutrophil count at least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no ...
A DNA repair pathway-focused score has the potential to help determine if first-line platinum based chemotherapy can benefit advanced-stage ovarian cancer patients, according to a study published April 13 in the Journal of the National Cancer Institute.. Most ovarian cancer patients are diagnosed with advanced disease (stages III and IV). They undergo surgery to remove as much tumor as possible, and then undergo platinum-based chemotherapy. But tools to predict response to platinum-based chemotherapy in ovarian cancer patients have been inadequate.. In order to determine if a DNA repair pathway-focused score could help predict outcomes for ovarian cancer patients treated with platinum-based chemotherapy, Josephine Kang, M.D., Ph.D., of the Department of Radiation Oncology at Dana Farber Cancer Institute, and colleagues gathered gene expression data from The Cancer Genome Atlas (TCGA) database for patients with advanced stage ovarian cancer, and established a molecular score by looking at the ...
Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum ...
The receptor tyrosine kinase AXL is thought to play a role in metastasis; however, the therapeutic efficacy of an AXL-targeting agent remains largely untested in metastatic disease. In this study, we defined AXL as a therapeutic target for metastatic ovarian cancer. AXL is primarily expressed in metastases and advanced-stage human ovarian tumors but not in normal ovarian epithelium. Genetic inhibition of AXL in human metastatic ovarian tumor cells is sufficient to prevent the initiation of metastatic disease in vivo. Mechanistically, inhibition of AXL signaling in animals with metastatic disease results in decreased invasion and matrix metalloproteinase activity. Most importantly, soluble human AXL receptors that imposed a specific blockade of the GAS6/AXL pathway had a profound inhibitory effect on progression of established metastatic ovarian cancer without normal tissue toxicity. These results offer the first genetic validation of GAS6/AXL targeting as an effective strategy for inhibition of
TY - JOUR. T1 - Expression of estrogen-responsive finger protein (Efp) is associated with advanced disease in human epithelial ovarian cancer. AU - Sakuma, Michiko. AU - Akahira, Jun Ichi. AU - Suzuki, Takashi. AU - Inoue, Satoshi. AU - Ito, Kiyoshi. AU - Moriya, Takuya. AU - Sasano, Hironobu. AU - Okamura, Kunihiro. AU - Yaegashi, Nobuo. N1 - Funding Information: This work was supported in part by a grant-in-aid for Scientific Research from the Ministry of Health and Welfare, a grant-in-aid from the Ministry of Education, Science and Culture, a grant-in-aid from Kurokawa Cancer Research Foundation, a grant-in-aid from Japan Gynecologic Oncology Group (JGOG) and the 21st Century Center of Excellence (COE) Program Special Research Grant from the Ministry of Education Science, Sports and Culture.. PY - 2005/12. Y1 - 2005/12. N2 - Objective. The estrogen-responsive ring finger protein (Efp) gene, one of estrogen receptor (ER) target genes, is considered to be essential for estrogen-dependent cell ...
TY - JOUR. T1 - A single nucleotide polymorphism in catalase is strongly associated with ovarian cancer survival. AU - Belotte, Jimmy. AU - Fletcher, Nicole M.. AU - Saed, Mohammed G.. AU - Abusamaan, Mohammed S.. AU - Dyson, Gregory. AU - Diamond, Michael P.. AU - Saed, Ghassan M.. PY - 2015/8/24. Y1 - 2015/8/24. N2 - Ovarian cancer is the deadliest of all gynecologic cancers. Recent evidence demonstrates an association between enzymatic activity altering single nucleotide polymorphisms (SNP) with human cancer susceptibility. We sought to evaluate the association of SNPs in key oxidant and antioxidant enzymes with increased risk and survival in epithelial ovarian cancer. Individuals (n = 143) recruited were divided into controls, (n = 94): healthy volunteers, (n = 18), high-risk BRCA1/2 negative (n = 53), high-risk BRCA1/2 positive (n = 23) and ovarian cancer cases (n = 49). DNA was subjected to TaqMan SNP genotype analysis for selected oxidant and antioxidant enzymes. Of the seven selected SNP ...
Younger women with early-stage ovarian cancer can keep the healthy ovary and uterus, according to the September 15, 2009, issue of Cancer....
MD Andersons physicians specialize in treating all types of ovarian cancer. Learn more about ovarian cancer treatment, surgery, chemotherapy and other options.
We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it in other ovarian carcinoma histotypes. p16 protein expression was assessed by clinical-grade immunohistochemistry in 6525 ovarian carcinomas including 4334 HGSC using tissue microarrays from 24 studies participating in the Ovarian Tumor Tissue Analysis consortium. p16 expression patterns were interpreted as abnormal (either overexpression referred to as block expression or absence) or normal (heterogeneous). CDKN2A (which encodes p16) mRNA expression was also analyzed in a subset (n = 2280) mostly representing HGSC (n = 2010). Association of p16 expression with overall survival (OS) was determined within histotypes as was CDKN2A expression for HGSC only. p16 block expression was most frequent in HGSC (56%) but neither protein nor mRNA expression was associated with OS. However, relative to heterogeneous expression, block expression was associated with shorter OS in
Epithelial ovarian cancer (EOC) is highly lethal gynecological cancer. Forkhead Box Protein C2 (FOXC2) promotes occurrence and development of various malignant tumors. The present study is aimed at exploring the correlation between the polymorphism of FOXC2 and epithelial ovarian cancer susceptibility in Chinese Han population. A case-control design was used to verify the association between FOXC2 polymorphisms and epithelial ovarian cancer. The genotyping was performed using Taqman® SNP Genotyping kit by qRT-PCR. The genetic variants including rs3751794 C | T, rs1035550 A | G, rs4843163 C | G and rs4843396 C | T in FOXC2 gene were analyzed. The strength of the associations was detected using odds ratios and 95% confidence intervals. Stratification analyses showed the association between the FOXC2 gene polymorphisms rs3751794 C | T, rs4843163 C | G and rs4843396 C | T with epithelial ovarian cancer susceptibility in terms of age, metastasis status, clinical stage, pathological grade, pregnant times,
The role of estrogen in the growth and survival of ovarian cancer cells is controversial. In this study, we investigated the changes in cell-cycle regulatory proteins in ovarian cancer cell lines after estrogen treatment to explore the role of estrog
Background Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine kinase that has an important function in cancers tumorigenesis and development. at both mRNA and proteins levels. Conclusion Used together, our outcomes demonstrate the fact that GSK-3 inhibitor AZD1080 suppresses ovarian cancers development and for that reason may indicate a fresh path for ovarian cancers treatment. strong course=kwd-title Keywords: ovarian cancers, GSK-3 inhibitor, AZD1080, tumorigenesis, development Introduction Ovarian cancers may be the third most common feminine reproductive system cancer tumor. The ovarian cancers mortality rate may be the highest from the gynecological malignancies because of the insufficient effective early diagnostic strategies, its chemotherapy level of resistance, and its capability to metastasize and recurrence. The 5-calendar year survival rate is certainly 30%, rendering it as a significant threat to medical and lives of females.1,2 Ovarian cancers has many ...
Cancer Monthly. Ovarian Cancer treatments. Chemotherapy. Memorial Sloan-Kettering Cancer Center, New York, NY, United States. Compare therapy differences, longest survival rates, toxicity, side effects, hospitals.
Cancer Monthly. Ovarian Cancer treatments. Chemotherapy. Sloan-Kettering Cancer Center, New York, United States. Compare therapy differences, longest survival rates, toxicity, side effects, hospitals.
Ovarian cancer is a type of cancer that begins in a womens ovaries. Women have two ovaries that produce eggs as well as the hormones estrogen and progesterone. Ovarian cancer can be hard to diagnose because early-stages of ovarian cancer rarely cause any symptoms and advanced-stage ovarian cancer may cause few and nonspecific symptoms. The symptoms of ovarian cancer may include abdominal bloating, quickly feeling full when eating, weight loss, cramping in the lower stomach, changes in bowel habits, and a frequent need to urinate.. The cause of ovarian cancer is unclear. In general, cancer is caused by genetic mutations that turn normal cells into abnormal cancer cells that quickly multiply, forming a mass (tumor). The type of cell where the cancer begins determines the type of ovarian cancer. These types included epithelial tumor, stromal tumor, and germ cell tumor. Certain factors may increase your risk of ovarian cancer. These include age (most common in women ages 50 to 60), estrogen hormone ...
The distribution of genotypes for Arg399Gln XRCC1 polymorphism in ovarian cancers vs. controls was: 58.0% vs. 38.5% for Arg/Arg, 32.0% vs. 26.9% for Arg/Gln, and 10.0% vs. 34.6% for Gln/Gln genotype, respectively. We found that XRCC1 Arg allele is associated with ovarian cancer risk (OR= 2.635 for Arg vs. Gln with 95% CI of 1.526 to 4.550). The Arg allele exerts its effect on increased risk for ovarian cancer development in dominant model (Arg/Arg plus Arg/Gln vs. Gln/Gln) with OR (and 95 % CI) of 4.765 (1.692 to 13.414) as well as in recessive model (Arg/Arg vs. Arg/Gln plus Gln/Gln) with OR (and 95 % CI) of 2.210 (1.072 to 4.555). ...
At Minnesota Oncology, ovarian cancer treatment options are individualized according to the patients type and stage of cancer and also other factors.
Table of Contents. 1 Market Overview. 1.1 Ovarian Cancer Treatment Drugs Introduction. 1.2 Market Analysis by Type. 1.2.1 Platinum Anticancer Drugs. 1.2.2 Fluoropyrimidines. 1.2.3 Anthracycline Antibiotics. 1.2.4 Therapertic Antibody. 1.2.5 Small Molecules Drug. 1.2.6 Aromatase Inhibitors (Targeted Therapy Drug). 1.2.7 Anti-estrogens. 1.2.8 Aromatase Inhibitors (Endocrine Therapy Drug). 1.3 Market Analysis by Applications. 1.3.1 Hospital. 1.3.2 Clinic. 1.3.3 Drugstore. 1.4 Market Analysis by Regions. 1.4.1 North America (United States, Canada and Mexico). 1.4.1.1 United States Market States and Outlook (2013-2023). 1.4.1.2 Canada Market States and Outlook (2013-2023). 1.4.1.3 Mexico Market States and Outlook (2013-2023). 1.4.2 Europe (Germany, France, UK, Russia and Italy). 1.4.2.1 Germany Market States and Outlook (2013-2023). 1.4.2.2 France Market States and Outlook (2013-2023). 1.4.2.3 UK Market States and Outlook (2013-2023). 1.4.2.4 Russia Market States and Outlook (2013-2023). 1.4.2.5 ...
This study focuses on Chinas Ovarian Cancer Treatment Drugs industry assessments and company profiles. In the two past decades, the industry has been growing at a fast pace. The dramatic expansions of the manufacturing capabilities and rising consumer consumptions in China have transformed Chinas society and economy. China is one of the worlds major producers for industrial and consumer products. Far outpacing other economies in the world, China is the worlds fastest growing market for the consumptions of goods and services. The Chinese economy maintains a high speed growth which has been stimulated by the consecutive increases of industrial output, imports & exports, consumer consumption and capital investment for over two decades. Rapid consolidation between medium and large players is anticipated since the Chinese government has been encouraging industry consolidation with an effort to regulate the industry and to improve competitiveness in the world market ...
TY - JOUR. T1 - Pathology of stage I versus stage III ovarian carcinoma with implications for pathogenesis and screening. AU - Yemelyanova, A. V.. AU - Cosin, J. A.. AU - Bidus, M. A.. AU - Boice, C. R.. AU - Seidman, J. D.. PY - 2008/5/1. Y1 - 2008/5/1. N2 - The progression of ovarian carcinoma from stage I when it is confined to the ovaries and curable to disseminated abdominal disease, which is usually fatal, is poorly understood. An accurate understanding of this process is fundamental to designing, testing, and implementing an effective screening program for ovarian cancer. Pathologic features of the primary ovarian tumors in 41 FIGO stage I ovarian carcinomas were compared with those in 40 stage III carcinomas. The primary ovarian tumors in stage I cases, when compared with stage III, respectively, were significantly larger (15.4 versus 9.8 cm), were less frequently bilateral (12% versus 75%), more frequently contained a noninvasive component (88% versus 30%), had a higher proportion of a ...
The aim of the study was to investigate long-term trends in the incidence of borderline tumors and ovarian cancer in Sweden during 1960-2005, based on data from the population-based Swedish Cancer Register. We identified 6,288 patients with borderline ovarian tumors and a total of 34,977 cases of ovarian cancer during the study period. The age-standardized incidence of borderline ovarian tumors increased from 1.0 to 5.3 per 100,000 women-years from 1960-1964 to 2000-2005 and the incidence of ovarian cancer increased from 16.4 to 19.7 per 100,000 women-years from 1960-1964 to 1980-1989 and then declined to 16.6 per 100,000 women-years to the period 2000-2005. Borderline ovarian tumors comprised 15% of all primary ovarian neoplasms and the proportion increased from 8.3 to 23.6% during the study period. The median age at diagnosis for patients with borderline ovarian tumors and ovarian cancer was 55.2 and 61.6 years, respectively. In women younger than 40 years, 34% of all primary ovarian ...
Metastatic Ovarian Cancer-Pipeline Review, H2 2015. Summary. Global Markets Directs, Metastatic Ovarian Cancer-Pipeline Review, H2 2015, provides an overview of the Metastatic Ovarian Cancers therapeutic pipeline.. This report provides comprehensive information on the therapeutic development for Metastatic Ovarian Cancer, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Metastatic Ovarian Cancer and special features on late-stage and discontinued projects.. Global Markets Directs report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Directs proprietary databases, Company/University websites, SEC ...
TY - JOUR. T1 - Role of CSF-1 in progression of epithelial ovarian cancer. AU - Chambers, Setsuko K. PY - 2009. Y1 - 2009. N2 - Despite the dismal outcome seen in the majority of epithelial ovarian cancer patients, there is ongoing progress in understanding the disease at a molecular level. Elucidation of pathways underlying disease progression and metastasis of ovarian cancer is key to development of targeted therapeutics. It is only in this way that therapeutic potential can be translated to reality. Here, we describe the evidence to date for the role of CSF-1/c-fms signaling in ovarian cancer invasiveness and metastasis, including the recent understanding of how CSF-1/c-fms expression is regulated with identification of significant post-transcriptional regulators.. AB - Despite the dismal outcome seen in the majority of epithelial ovarian cancer patients, there is ongoing progress in understanding the disease at a molecular level. Elucidation of pathways underlying disease progression and ...
The biology of ovarian carcinoma differs from that of hematogenously metastasizing tumors because ovarian cancer cells primarily disseminate within the peritoneal cavity and are only superficially invasive. However, since the rapidly proliferating tumors compress visceral organs and are only temporarily chemosensitive, ovarian carcinoma is a deadly disease, with a cure rate of only 30%. There are a number of genetic and epigenetic changes that lead to ovarian carcinoma cell transformation. Ovarian carcinoma could originate from any of three potential sites: the surfaces of the ovary, the fallopian tube, or the mesothelium-lined peritoneal cavity. Ovarian cacinoma tumorigenesis then either progresses along a stepwise mutation process from a slow growing borderline tumor to a well-differentiated carcinoma (type I) or involves a genetically unstable high-grade serous carcinoma that metastasizes rapidly (type II). During initial tumorigenesis, ovarian carcinoma cells undergo an ...
(HealthDay)-Operative outcomes of laparoscopic approach in patients with early-stage ovarian cancer may be comparable with those of laparotomy, according to a meta-analysis published in the July issue of the American Journal ...
TY - JOUR. T1 - Correlation of p53 immunostaining in primary and residual ovarian cancer at the time of positive second-look laparotomy and its prognostic role. T2 - A Southwest Oncology Group ancillary study. AU - Hawes, Debra. AU - Liu, P. Y.. AU - Muggia, Franco M.. AU - Wilczynski, Sharon. AU - Cote, Richard. AU - Felix, Juan. AU - Terada, Keith. AU - Belt, Robert J.. AU - Alberts, David S. PY - 2002. Y1 - 2002. N2 - Objective. The objective of this study was to verify the correlation between p53 immunostaining at initial diagnosis and at positive reassessment after completing platinum-based chemotherapy and to assess prognostic differences between patients whose tumors display positive immunostaining versus those that have negative immunostaining at such reassessment. Methods. This study made use of samples from patients entered into a prospective randomized study of the Southwest Oncology Group (SWOG 8835) that treated patients with minimal residual disease at second-look laparotomy with ...
Title:PARP Inhibitors in Epithelial Ovarian Cancer. VOLUME: 13 ISSUE: 2. Author(s):Kristin N. Taylor and Ramez N. Eskander*. Affiliation:Rebecca and John Moores Cancer Center, Department of Reproductive Medicine, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, Rebecca and John Moores Cancer Center, Department of Reproductive Medicine, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA. Keywords:BRCA mutation, homologous recombination deficiency, PARP inhibitor, poly (ADP-ribose) polymerase, ovarian cancer, synthetic lethality.. Abstract:Background: Ovarian cancer remains the most common lethal gynecologic malignancy. The therapeutic gains with the use of traditional cytotoxic chemotherapy in advanced stage disease remain limited, reflecting the need for novel therapies. Poly(ADP-ribose) polymerase (PARP) inhibitors have recently demonstrated a significant therapeutic effect in patients with recurrent, high grade serous ovarian ...
TY - JOUR. T1 - Ovarian cancer detection by DNA methylation in cervical scrapings. AU - Wu, Tzu I.. AU - Huang, Rui Lan. AU - Su, Po Hsuan. AU - Mao, Shih Peng. AU - Wu, Chen Hsuan. AU - Lai, Hung Cheng. PY - 2019/11/27. Y1 - 2019/11/27. N2 - Background: Ovarian cancer (OC) is the most lethal gynecological cancer, worldwide, largely due to its vague and nonspecific early stage symptoms, resulting in most tumors being found at advanced stages. Moreover, due to its relative rarity, there are currently no satisfactory methods for OC screening, which remains a controversial and cost-prohibitive issue. Here, we demonstrate that Papanicolaou test (Pap test) cervical scrapings, instead of blood, can reveal genetic/epigenetic information for OC detection, using specific and sensitive DNA methylation biomarkers. Results: We analyzed the methylomes of tissues (50 OC tissues versus 6 normal ovarian epithelia) and cervical scrapings (5 OC patients versus 10 normal controls), and integrated public methylomic ...
MicroRNAs (miRNAs) are small noncoding RNAs that have important roles in gene regulation. We have previously reported that activin receptor-like kinase 7 (ALK7) and its ligand, Nodal, induce apoptosis in human epithelial ovarian cancer cells. In this study, we examined the regulation of ALK7 by miRNAs and demonstrate that miR-376c targets ALK7. Ectopic expression of miR-376c significantly increased cell proliferation and survival, enhanced spheroid formation and blocked Nodal-induced apoptosis. Interestingly, overexpression of miR-376c blocked cisplatin-induced cell death, whereas anti-miR-376c enhanced the effect of cisplatin. These effects of miR-376c were partially compensated by the overexpression of ALK7. Moreover, in serous carcinoma samples taken from ovarian cancer patients who responded well to chemotherapy, strong ALK7 staining and low miR-376c expression was detected. By contrast, ALK7 expression was weak and miR-376c levels were high in samples from patients who responded poorly to ...
In this study a new low-grade serous ovarian carcinoma cell line, named as CAISMOV24, was characterized in terms of its in vitro cell growth, production of soluble biomarkers and expression of cell surface molecules. Additionally, CAISMOV24 was molecularly characterized and compared to its primary malignant cells for genomic alterations. In vitro models of well-characterized low-grade serous ovarian cell lines are currently limited in the literature. CAISMOV24 resulted from the in vitro spontaneous immortalization of primary malignant cells from ascites that was associated with a low-grade serous ovarian carcinoma. Although malignant cells of ovarian neoplasia from either tumor tissue or ascites can be cultivated in vitro for a limited period, only a minority of the primary cell cultures may become cell lines [14]. Spontaneous immortalization of primary cultures of malignant cells is an event occurring at a very low frequency. As an example, ODonnell et al. [11] reported the occurrence of only ...
Stage three ovarian cancer survival rate is somewhat high. Stage 3 is a serious level of ovarian cancer but life expectancy is still considered high. Abo
Research highlights: {yields} PPAR{gamma} ligands increased the rate of apoptosis and inhibition of proliferation in ovarian cancer cells. {yields} PPAR{gamma} ligands induced p63 and p73 expression, but not p53. {yields} p63 and p73 leads to an increase in p21 expression and apoptosis in ovarian cancer cells with treatment PPAR{gamma} ligands. {yields} These findings suggest that PPAR{gamma} ligands suppressed growth of ovarian cancer cells through upregulation of p63 and p73. -- Abstract: Peroxisome proliferator-activated receptor gamma (PPAR{gamma}) agonists, including thiazolidinediones (TZDs), can induce anti-proliferation, differentiation, and apoptosis in various cancer cell types. This study investigated the mechanism of the anticancer effect of TZDs on human ovarian cancer. Six human ovarian cancer cell lines (NIH:OVCAR3, SKOV3, SNU-251, SNU-8, SNU-840, and 2774) were treated with the TZD, which induced dose-dependent inhibition of cell growth. Additionally, these cell lines exhibited ...
Bisphenol A (BPA) is one of the most prevalent chemicals in many products used on a daily basis, making human exposure to it incredibly pervasive and raising concerns about its health consequences. One area of research focus has been the role of BPA exposure in promoting the development of ovarian cancer; however, the doses used in most of previous studies are relatively high and most likely exceed physiologically relevant levels. At the same time, few studies have described potential mechanisms underlying the link between BPA and increased cancer risk. To address these concerns, the authors investigated the mechanism(s) by which low concentrations of BPA promote proliferation and energy metabolism in the human ovarian cancer cell line OVCAR-3. The results showed that even sub-toxic BPA concentrations not only drove increased OVCAR-3 cell proliferation but also promoted glycolysis-based metabolism, as evidenced by elevated cell viability, accelerated cell proliferation, increased levels of ...
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TY - JOUR. T1 - Artificial intelligence weights the importance of factors predicting complete cytoreduction at secondary cytoreductive surgery for recurrent ovarian cancer. AU - Bogani, Giorgio. AU - Rossetti, Diego. AU - Ditto, Antonino. AU - Martinelli, Fabio. AU - Chiappa, Valentina. AU - Mosca, Lavinia. AU - Leone Roberti Maggiore, Umberto. AU - Ferla, Stefano. AU - Lorusso, Domenica. AU - Raspagliesi, Francesco. N1 - Copyright © 2018. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology.. PY - 2018/9. Y1 - 2018/9. N2 - OBJECTIVE: Accumulating evidence support that complete cytoreduction (CC) at the time of secondary cytoreductive surgery (SCS) improves survival in patients affected by recurrent ovarian cancer (ROC). Here, we aimed to determine whether artificial intelligence (AI) might be useful in weighting the importance of clinical variables predicting CC and survival.METHODS: This is a retrospective study evaluating 194 patients having SCS for ROC. Using ...
TY - JOUR. T1 - Methiothepin suppresses human ovarian cancer cell growth by repressing mitochondrion-mediated metabolism and inhibiting angiogenesis in vivo. AU - Lee, Jin Young. AU - Yang, Changwon. AU - Lim, Whasun. AU - Song, Gwonhwa. N1 - Funding Information: This research was supported by the NRF of Korea grant funded by the Ministry of Science and ICT (2018R1C1B6009048). Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.. PY - 2020/7. Y1 - 2020/7. N2 - Ovarian cancer is the fifth leading cause of cancer-related deaths in women. Despite treatment, most patients experience relapse and the 5-year survival rate of ovarian cancer is less than 50%. Serotonin has cell growth-promoting functions in a variety of carcinomas, but the effect of serotonin receptor antagonists on ovarian cancer cells is unknown. In this study, it was confirmed that methiothepin, a serotonin receptor antagonist, suppresses the viability of, and induces apoptosis in, ovarian cancer cells. ...
Mucinous epithelial ovarian cancers are clinically and morphologically distinct through the various other histopathologic subtypes of ovarian cancer. signaling pathways. Immunohistochemistry of archived ovarian specimens showed significant overexpression of eight of the nine target antigens in mucinous ovarian tumor tissues, suggesting that plasma autoantibodies from mucinous ovarian cancer patients might have heightened reactivities with epitopes presented by these overexpressed antigens. Autoantibody profiling may have an unexpected power in uncovering key signaling pathways that are dysregulated in the system of interest. or mutations, have frequent mutations and modest ratio between the serum markers CA125 and carcinoembryonic antigen CEA (5). Molecular and pathologic studies also support a progression model for the development of mucinous ovarian tumors (6). Transitions between benign and malignant areas are seen in 80% of malignant mucinous adenocarcinomas. Identical mutations are ...
GATA3 as a master regulator for interactions of tumor-associated macrophages with high-grade serous ovarian carcinoma. Cell Signal. 2020 Jan 11;:109539 Authors: El-Arabey AA, Denizli M, Kanlikilicer P, Bayraktar R, Ivan C, Rashed M, Kabil N, Ozpolat B, Calin GA, Salama SA, Abd-Allah AR, Sood AK, Lopez-Berestein G Abstract High-grade serous ovarian carcinoma (HGSOC) is the mos...
TY - JOUR. T1 - Quantitative analysis of follicle-stimulating hormone receptor in ovarian epithelial tumors. T2 - A novel approach to explain the field effect of ovarian cancer development in secondary mullerian systems. AU - Wang, Jun. AU - Lin, Lynne. AU - Parkash, Vinita. AU - Schwartz, Peter E.. AU - Lauchlan, Stuart C.. AU - Zheng, Wenxin. PY - 2003/1/20. Y1 - 2003/1/20. N2 - The role of FSHR expression in ovarian cancer development is not clear. We examined quantitative expression of FSHR in different types of OET, presumed precursor lesions and peritoneal implants and further discussed FSH as a key growth-promotion factor for the process of ovarian epithelial tumorigenesis. Thirty-five primary OET specimens, including 5 serous cystadenomas, 4 papillary serous cystadenomas, 9 SBTs and 17 serous carcinomas, were examined for quantitative FSHR expression. Ten paired samples (3 benign cystadenomas, 5 SBTs and 2 carcinomas) were obtained from several morphologically different areas, including ...
TY - JOUR. T1 - Novel mechanism of reduced proliferation in ovarian clear cell carcinoma cells. T2 - Cytoplasmic sequestration of CDK2 by p27. AU - Itamochi, Hiroaki. AU - Yoshida, Tomokazu. AU - Walker, Cheryl Lyn. AU - Bartholomeusz, Chandra. AU - Aoki, Daisuke. AU - Ishihara, Hideki. AU - Suzuki, Nao. AU - Kigawa, Junzo. AU - Terakawa, Naoki. AU - Ueno, Naoto T.. PY - 2011/9. Y1 - 2011/9. N2 - Objective: Ovarian clear cell carcinoma (CCC) carries a poor prognosis because of its insensitivity to chemotherapy. We previously found an association between reduced proliferation of CCC and chemoresistance; here we investigated the mechanism of the reduced proliferation. Methods: We assessed cell cycle function by measuring the activity of cyclin-dependent kinases (CDKs) and the protein expression of cyclins, the CDK inhibitors, and p53 in 22 ovarian cancer cell lines and 60 human ovarian cancer specimens. We examined the cellular location of p27, p27 phosphorylated at threonine 157 (p27Thr157), and ...
TY - JOUR. T1 - Endometrial cancers in mutation carriers from hereditary breast ovarian cancer syndrome kindreds. AU - Casey, Murray J.. AU - Bewtra, Chhanda. AU - Lynch, Henry T.. AU - Snyder, Carrie L.. AU - Stacey, Mark. PY - 2015/5/7. Y1 - 2015/5/7. N2 - Objective The aim of this study was to categorize and report endometrial cancers in mutation carriers from hereditary breast ovarian cancer families. Methods Our Hereditary Cancer Registry was searched for gynecologic and peritoneal cancers linked to mutations in BRCA1 or BRCA2. Invasive cancers were registered in 101 mutation carriers with complete pathology reports. Efforts were made to secure diagnostic surgical pathology tissues for review. All records and available diagnostic slides were meticulously studied, and primary cancers were classified. Findings Eight malignancies were classified as primary endometrial cancers. Five of these were low- or intermediate-grade endometrioid carcinomas, and 3 were pure serous carcinomas or contained ...
The expression of mismatch repair proteins hMSH2 and hMLH1 was investigated in human ovarian cancer cell lines and in biopsies of ovarian carcinomas obtained from 20 patients undergoing surgical operation. By Western blotting analysis hMSH2 protein was detected in all the tumor samples analyzed and in eight out of nine human ovarian cancer cell lines, while hMLH1 was undetectable in four out of 20 ovarian tumors and in five out of nine human ovarian cancer cell lines analyzed. The possible presence of frameshift mutations in the BAX gene, which contains a sequence of eight contiguous guanines in its third exon, was tested in all the samples. All the cell lines presented the normal alleles for the BAX gene while only in one of the tumor samples a heterozygous frameshift mutation was found. The frameshift mutation was associated to a low, almost undetectable, level of BAX protein which was instead present at much higher levels in all the other samples investigated. The results indicate that ...
Krukenbergs tumours are metastatic tumours of the ovary. The colon and stomach are the most common primary tumour sites. Breast, lung, and pancreas are the other sites of metastasis. These tumours constitute 5-10% of ovarian neoplasms.. The differential diagnosis from a primary ovarian tumour is very important for therapeutic approach. Krukenbergs tumours are bilateral in 60-80% of cases. Therefore whenever bilateral ovarian involvement is detected, a search for a primary site, especially in the gastrointestinal system, should be carried out. In contrast to primary ovarian tumours, the ovaries keep their shape in Krukenbergs tumour. Some other radiological findings give important clues. Early in the development of these tumours, the solid component is most prominent, as seen in this case. At US Krukenberg tumor typically present as bilateral, solid ovarian masses, with clear well defined margins. An irregular hyperechoic solid pattern and moth eaten like cyst formation are also ...
Ascites formation is often observed in ovarian cancer patients. Vascular permeability factor (VPF) may induce ascites formation. We established an animal model of ascites formation and re-accumulation by i.p. transplantation of a human ovarian adenocarcinoma cell line, NOS2, into nude mice. The form …
Curcumin is a natural molecule with proved anticancer efficacy on several human cancer cell lines. However, its clinical application has been limited due to its poor bioavailability. Nanocarrier-based drug delivery approaches could make curcumin dispersible in aqueous media, thus overtaking the limits of its low solubility. The aim of this study was to increase the bioavailability and the antitumoral activity of curcumin, by entrapping it into nanostructured lipid carriers (NLCs). For this purpose here we describe the preparation and characterization of three kinds of curcumin-loaded NLCs. The nanosystems allowed the achievement of a controlled release of curcumin, the amounts of curcumin released after 24 h from Compritol-Captex, Compritol-Miglyol, and Compritol NLCs being, respectively, equal to 33, 28, and 18% w/w on the total entrapped curcumin. Considering the slower curcumin release profile, Compritol NLCs were chosen to perform successive in vitro studies on ovarian cancer cell lines. The ...
Chemokine receptor-ligand interactions are important to support functioning of both normal and pathologic cells. The expression and function of chemokine receptors in epithelial ovarian carcinoma (EOC) is largely unknown. Here, we report that the lymphotactin receptor (XCR1) was expressed in primary and metastatic human epithelial ovarian carcinoma (EOC) specimens and cell lines. In contrast, expression of XCR1 was not detected in the normal ovary or in human normal ovarian surface epithelial cells. Our data indicate that XCL1 and XCL2 are either present in the malignant ascites or expressed by the ovarian carcinoma cells. The addition of lymphotactin (XCL1 and XCL2) stimulated migration and proliferation of XCR1-positive cells. Reduction of XCR1 expression in ovarian carcinoma cell line SKOV-3 resulted in abrogated diaphragm and peritoneal wall tumor formation and in reduced frequency of colonic, splenetic, and liver nodules in an in vivo xenograft mouse model. Taken together, our data suggest ...
Combination drug therapy appears a promising approach to overcome drug resistance and reduce drug-related toxicities in ovarian cancer treatments. In this in vitro study, we evaluated the antitumor efficacy of cisplatin in combination with Bithionol (BT) against a panel of ovarian cancer cell lines with special focus on cisplatin-sensitive and cisplatin-resistant cell lines. The primary objectives of this study are to determine the nature of the interactions between BT and cisplatin and to understand the mechanism(s) of action of BT-cisplatin combination. The cytotoxic effects of drugs either alone or in combination were evaluated using presto-blue assay. Cellular reactive oxygen species were measured by flow cytometry. Immunoblot analysis was carried out to investigate changes in levels of cleaved PARP, XIAP, bcl-2, bcl-xL, p21 and p27. Luminescent and colorimetric assays were used to test caspases 3/7 and ATX activity. The efficacy of the BT-cisplatin combination depends upon the cell type and
The expression of mRNA for the epidermal growth factor (EGF) receptor, EGF and transforming growth factor alpha (TGF-alpha) was determined in 76 malignant, six borderline and 15 benign primary ovarian tumours using the reverse transcriptase-polymerase chain reaction and related to clinical and pathological parameters. Of the malignant tumours, 70% (53/76) expressed EGF receptor mRNA, 31% (23/75) expressed EGF mRNA and 35% (26/75) expressed TGF-alpha mRNA. For the borderline tumours, four of six (67%) expressed EGF receptor mRNA, 1/6 (17%) expressed TGF-alpha mRNA and none expressed EGF mRNA. Finally, 33% (5/15) of the benign tumours expressed EGF receptor mRNA, whereas 40% (6/15) expressed EGF mRNA and 7% (1/15) expressed TGF-alpha mRNA. The presence of the EGF receptor in malignant tumours was associated with that of TGF-alpha (P = 0.0015) but not with EGF (P = 1.00), whereas there was no relationship between the presence of EGF and TGF-alpha (P = 1.00). EGF receptor mRNA expression was significantly
TY - JOUR. T1 - Correlation of p53 immunostaining in primary and residual ovarian cancer at the time of positive second-look laparotomy and its prognostic role. T2 - A Southwest Oncology Group ancillary study. AU - Hawes, Debra. AU - Liu, P. Y.. AU - Muggia, Franco M.. AU - Wilczynski, Sharon. AU - Cote, Richard J. AU - Felix, Juan. AU - Terada, Keith. AU - Belt, Robert J.. AU - Alberts, David S.. PY - 2002/12/1. Y1 - 2002/12/1. N2 - Objective. The objective of this study was to verify the correlation between p53 immunostaining at initial diagnosis and at positive reassessment after completing platinum-based chemotherapy and to assess prognostic differences between patients whose tumors display positive immunostaining versus those that have negative immunostaining at such reassessment. Methods. This study made use of samples from patients entered into a prospective randomized study of the Southwest Oncology Group (SWOG 8835) that treated patients with minimal residual disease at second-look ...
Abstract Hyperthermic intraperitoneal chemotherapy (HIPEC) has shown promise in the treatment of ovarian carcinosis. Despite its efficiency for the treatment of peritoneal carcinosis from digestive tract neoplasia, it has failed to demonstrate significant benefit in ovarian cancers. It is therefore essential to understand the mechanism underlying the resistance to HIPEC in ovarian cancers. Mesenchymal Stem Cells (MSC) play an important role in the development of ovarian cancer metastasis and resistance to treatments. A recent study suggests that MSCs may be cytotoxic for cancer cells upon heat shock. In contrast, we describe the protective role of MSC against hyperthermia. Using cytokine arrays we determined that tumor associated MSC (TAMC) secrete pro-tumoral cytokines. We studied the effect of hyperthermia in co-culture setting of TAMC or bone marrow derived-MSC (BM-MSC) associated with ovarian cancer cell lines (SKOV3 and CaOV3) with polyvariate flow cytometry. We demonstrate that hyperthermia does
RATIONALE: Biological therapies such as gefitinib may interfere with the growth of the tumor cells and may slow the growth of ovarian epithelial cancer
TY - JOUR. T1 - Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium. AU - Pearce, C. L.. AU - Near, A. M.. AU - Van Den Berg, D. J.. AU - Ramus, S. J.. AU - Gentry-Maharaj, A.. AU - Menon, U.. AU - Gayther, S. A.. AU - Anderson, A. R.. AU - Edlund, C. K.. AU - Wu, A. H.. AU - Chen, X.. AU - Beesley, J.. AU - Webb, P. M.. AU - Holt, S. K.. AU - Chen, C.. AU - Doherty, J. A.. AU - Rossing, M. A.. AU - Whittemore, A. S.. AU - McGuire, V.. AU - DiCioccio, R. A.. AU - Goodman, M. T.. AU - Lurie, G.. AU - Carney, M. E.. AU - Wilkens, L. R.. AU - Ness, R. B.. AU - Moysich, K. B.. AU - Edwards, R.. AU - Jennison, E.. AU - Kjaer, S. K.. AU - Hogdall, E.. AU - Hogdall, C. K.. AU - Goode, E. L.. AU - Sellers, T. A.. AU - Vierkant, R. A.. AU - Cunningham, J. C.. AU - Schildkraut, J. M.. AU - Berchuck, A.. AU - Moorman, P. G.. AU - Iversen, E. S.. AU - Cramer, D. W.. AU - Terry, K. L.. AU - Vitonis, A. F.. AU - Titus-Ernstoff, L.. AU - Song, ...
TY - JOUR. T1 - Ovarian cancer risk factors by tumor aggressiveness. T2 - An analysis from the Ovarian Cancer Cohort Consortium. AU - Fortner, Renee T.. AU - Poole, Elizabeth M.. AU - Wentzensen, Nicolas A.. AU - Trabert, Britton. AU - White, Emily. AU - Arslan, Alan A.. AU - Patel, Alpa. AU - Setiawan, V. Wendy. AU - Visvanathan, Kala. AU - Weiderpass, Elisabete. AU - Adami, Hans-Olov. AU - Black, Amanda. AU - Bernstein, Leslie. AU - Brinton, Louise A.. AU - Buring, Julie. AU - Clendenen, Tess. AU - Fournier, Agnes. AU - Fraser, Gary. AU - Gapstur, Susan M.. AU - Gaudet, Mia M.. AU - Giles, Graham G.. AU - Gram, Inger T.. AU - Hartge, Patricia. AU - Hoffman-Bolton, Judith. AU - Idahl, Annika. AU - Kaaks, Rudolf. AU - Kirsh, Victoria A.. AU - Knutsen, Synnove. AU - Koh, Woon-Puay. AU - Lacey, James V.. AU - Lee, I-Min. AU - Lundin, Eva. AU - Merritt, Melissa A.. AU - Milne, Roger L.. AU - Onland-Moret, N. Charlotte. AU - Peters, Ulrike. AU - Poynter, Jenny N.. AU - Rinaldi, Sabina. AU - Robien, ...
Epithelial ovarian cancer (EOC) is one of the leading causes of cancer deaths in women worldwide. Ubiquitin-conjugating enzyme 9 (Ubc9), the sole conjugating enzyme for sumoylation, regulates protein function and plays an important role in sumoylation-mediated cellular pathways. Although sumoylation plays a key role in DNA repair and tumorgenesis, whether Ubc9 is involved in EOC progression remains unknown. In the present study, we constructed Ubc-9 expressed recombined plasmid pEGFP-N1-Ubc9. The mRNA levels of Ubc9 were confirmed in human ovarian cell lines before and after transfection with pEGFP-N1-Ubc9 or small interfering RNA (siRNA) targeted Ubc9 by real-time polymerase chain reaction (PCR). The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to observe the effect of Ubc9 on cell proliferation. The protein levels of Ubc9, and proliferation-related signals Akt and physphorylated Akt were determined by Western blot. Our results showed that proliferation of EOC
Doctors give trusted, helpful answers on causes, diagnosis, symptoms, treatment, and more: Dr. Hashemi on ovarian granulosa cell tumor: Sperm in men (&testosterone) and eggs/ova in women (& estrogens), and these are also the sites of germ cell tumors. Outside the gonads, the mediastinum and brain (pineal) are the most common extragonadal sites. These are known to produce markers (hcg, alphafeto-protein) and responsve and curable with chemotherapy. Hope this helps.
The therapeutic effect of a combination of paclitaxel (PTX) and platinum (PLT) in ovarian clear cell adenocarcinoma (CC) patients with measurable disease has yet to be elucidated. In this study, we used retrospective review to evaluate the results of treatment with a combination of PTX and PLT in CC patients with measurable disease. A total of 28 patients with measurable residual CC (15 cases with primary disease, 13 cases with recurrent disease) treated with combination PTX-PLT chemotherapy was identified through medical records from ten institutions. Clinical response to chemotherapy was evaluated using Response Evaluation Criteria in Solid Tumors criteria. Of the 28 cases, 8 of 15 patients with primary disease (53.3%) and 3 of 13 patients with recurrent disease (23.1%) responded to PTX-PLT chemotherapy. The response rate for cases with late recurrent disease (,12 months) was 20% (1/5), whereas the rate was 25% (2/8) for cases with early recurrent (,12 months) or refractory disease. Our ...
Oncolytics Biotech Inc. (Oncolytics) announced today that patient enrolment has started in a Phase 1/2 clinical trial for patients with metastatic ovarian, peritoneal and fallopian tube cancers using concurrent intravenous (IV) and intraperitoneal (IP)REOLYSIN®, Oncolytics proprietary formulation of the human reovirus. ... A cell with an activated Ras Pathway, which has lost its ability to…
Beamer, W G.; Shultz, K L.; Tennent, B J.; Azumi, N; and Sundberg, J P., Mouse model for malignant juvenile ovarian granulosa cell tumors. (1998). Faculty Research 1990 - 1999. 1160 ...
Despite increasing evidence that precision therapy targeted to the molecular drivers of a cancer has the potential to improve clinical outcomes, high-grade epithelial ovarian cancer (OC) patients are currently treated without consideration of molecular phenotype, and predictive biomarkers that could better inform treatment remain unknown. Delivery of precision therapy requires improved integration of laboratory-based models and cutting-edge clinical research, with pre-clinical models predicting patient subsets that will benefit from a particular targeted therapeutic. Patient-derived xenografts (PDXs) are renewable tumor models engrafted in mice, generated from fresh human tumors without prior in vitro exposure. PDX models allow an invaluable assessment of tumor evolution and adaptive response to therapy. PDX models have been applied to pre-clinical drug testing and biomarker identification in a number of cancers including ovarian, pancreatic, breast, and prostate cancers. These models have been shown to
A new study finds that young women with early stage ovarian cancer can preserve future fertility by keeping at least one ovary or the uterus without increasing the risk of dying from the disease.
Vascular endothelial growth factor (VEGF)-A inhibitors exhibit unseen high responses and toxicity in recurrent epithelial ovarian cancer suggesting an important role for the VEGF/VEGFR pathway. We studied the correlation of VEGF signalling and AKT/mTOR signalling. Using a tissue microarray of clinical samples (N=86), tumour cell immunohistochemical staining of AKT/mTOR downstream targets, pS6 and p4E-BP1, together with tumour cell staining of VEGF-A and pVEGFR2 were semi-quantified. A correlation was found between the marker for VEGFR2 activation (pVEGFR2) and a downstream target of AKT/mTOR signalling (pS6) (R=0.29; P=0.002). Additional gene expression analysis in an independent cDNA microarray dataset (N=24) showed a negative correlation (R=−0.73, P|0.0001) between the RPS6 and the VEGFR2 gene, which is consistent as the gene expression and phosphorylation of S6 is inversely regulated. An activated tumour cell VEGFR2/AKT/mTOR pathway was associated with increased incidence of ascites (χ2, P=0.002)
TY - JOUR. T1 - Ovarian clear cell adenocarcinoma revealed in a young patient during hormone therapy: a case report. AU - Kawai, Satoshi. AU - Ichikawa, Ryoko. AU - Ueda, Takahiro. AU - Urano, Makoto. AU - Kuroda, Makoto. AU - Fujii, Takuma. PY - 2016. Y1 - 2016. U2 - 10.20407/fmj.2.4_77. DO - 10.20407/fmj.2.4_77. M3 - Article. VL - 2. SP - 77. EP - 79. JO - Fujita medical journal. JF - Fujita medical journal. SN - 2189-7247. IS - 4. ER - ...
Learn how Avastin® (bevacizumab) works in recurrent platinum-treated ovarian cancer including platinum-resistant ovarian cancer (prOC) and platinum-sensitive ovarian cancer (psOC) Metastatic Colorectal Cancer (mCRC) Avastin is approved to treat metastatic colorectal cancer (mCRC) for: First- or second-line treatment in combination with intravenous 5-fluorouracil-based chemotherapy Second-line treatment when used with fluoropyrimidine-based (combined with irinotecan or oxaliplatin) chemotherapy after cancer progresses following a first-line treatment that includes Avastin. Avastin is not approved for use after the primary treatment of colon cancer that has not spread to other parts of the body. Glioblastoma (GBM) Avastin is approved to treat glioblastoma (GBM) when taken alone in adult patients whose cancer has progressed after prior treatment (recurrent or rGBM). The effectiveness of Avastin in rGBM is based on tumor response. Currently, no data have shown whether or not Avastin improves disease
High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of ovarian cancer deaths, and overall survival has not changed significantly for several decades. In this Opinion article, we outline a set of research priorities that we believe will reduce incidence and improve outcomes for women with this disease. This roadmap for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015.
Semaphorins comprise a family of molecules that influence neuronal growth and guidance. Class-3 semaphorins, semaphorin-3B (SEMA3B) and semaphorin-3F (SEMA3F), illustrate their effects by forming a complex with neuropilins (NP-1 or NP-2) and plexins. We examined the status and regulation of semaphorins and their receptors in human ovarian cancer cells. A significantly reduced expression of SEMA3B (83 kDa), SEMA3F (90 kDa), and plexin-A3 was observed in ovarian cancer cell lines when compared with normal human ovarian surface epithelial cells. The expression of NP-1, NP-2, and plexin-A1 was not altered in human ovarian surface epithelial and ovarian cancer cells. The decreased expression of SEMA3B, SEMA3F, and plexin-A3 was confirmed in stage 3 ovarian tumors. The treatment of ovarian cancer cells with luteinizing hormone, follicle-stimulating hormone, and estrogen induced a significant upregulation of SEMA3B, whereas SEMA3F was upregulated only by estrogen. Cotreatment of cell lines with a ...
Mutations of NH2-terminal β-catenin sequences have been demonstrated in various human tumor types, including colorectal carcinomas (24 , 39) , melanomas (40) , hepatoblastomas (41) , medulloblastomas (42) , prostatic carcinomas (43 , 44) , and uterine endometrial carcinomas (45, 46, 47, 48) , particularly endometrioid adenocarcinomas with squamous differentiation (10) . Prior studies of ovarian carcinomas have indicated that β-catenin mutations are common only in OEAs, with estimated mutation frequencies of 16-54% (10, 11, 12, 13, 14) .. We have pursued our studies of the prevalence and mechanisms underlying β-catenin deregulation in 45 histologically verified frozen primary OEA tissues. This is, in fact, a substantial number of primary tumors of this particular histological subtype, because only 10-20% of ovarian carcinomas are endometrioid (49) . We identified CTNNB1 exon 3 mutations in 31% of our primary ovarian endometrioid carcinomas. Mutations inactivating the APC, AXIN1, and AXIN2 ...
Many studies have compared open surgery and laparoscopic surgery in gynecology. Furthermore, several studies have compared conventional laparoscopy using multiple ports and laparotomy in ovarian cancer [9,18,19-21]. However, no previous study has compared single-port laparoscopic surgery and laparotomy in ovarian cancer, although several studies have compared single-port and multiport laparoscopic surgery for benign gynecologic diseases [13,22]. Therefore, this study is the first to investigate the feasibility of single-port laparoscopic surgery by comparing SPLS and staging laparotomy in early ovarian cancer.. According to our results, SPLS has several advantages in terms of surgical outcomes, such as lower estimated blood loss, lower transfusion rate, less postoperative pain, and shorter postoperative hospital stay, while showing no significant differences in survival outcomes. Less blood loss is well known as one of the main advantages of minimally invasive surgery. In this study, there was ...
TY - JOUR. T1 - The chemosensitivity of nodal metastases in recurrent epithelial ovarian cancer. AU - Kataoka, F.. AU - Tsuda, H.. AU - Nomura, H.. AU - Chiyoda, T.. AU - Tominaga, E.. AU - Suzuki, A.. AU - Susumu, N.. AU - Aoki, D.. PY - 2011/5/11. Y1 - 2011/5/11. N2 - Purpose: In this study, we compared second-line chemotherapy effects of nodal metastases with other metastases sites. Methods: The medical records of 44 women with recurrent ovarian cancer who received second-line chemotherapy were retrospectively reviewed. Results: Median age at the time of second-line chemotherapy was 55 years (range: 31-74). Recurrent sites were as follows: 29 patients had a solitary site (abdominal cavity: 8; lymph node: 3; pelvic cavity: 10; liver: 4; lung: 4) and 15 patients had multiple sites In total, the response rate was 30% (CR: 8, PR: 5). The response rate in sensitive cases was higher than in refractory/resistant cases (50% vs 5% p = 0.002). However, age, chemotherapy regimen, histologic type and ...
Inclusion Criteria:. - Have recurrent epithelial ovarian cancer, primary peritoneal carcinomatosis or fallopian tube cancer. - Have platinum-resistant (recurrence within 6 months of a platinum-containing regimen) or platinum refractory (progression while on platinum) disease - Have measurable disease according to RECIST or detectable disease. o Measurable disease is defined as the presence of at least one uni-dimensionally measurable lesion greater than or equal to 20 mm by conventional techniques, including palpation, plain x-ray, CT scan or MRI, or greater than or equal to 10 mm by spiral CT scan. o Detectable disease is defined in a patient as one who does not have measurable disease but has at least one of the following conditions: 1) Baseline values of cancer antigen 125 (CA-125) at least twice the upper limit of normal; 2) Ascites and/or pleural effusion attributed to tumor; 3) solid and/or cystic abnormalities on radiographic imaging that do not meet RECIST definitions for target lesions. ...
High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of ovarian cancer deaths, and overall survival has not changed significantly for several decades. In this Opinion article, we outline a set of research priorities that we believe will reduce incidence and improve outcomes for women with th …
Ovarian cancer is the leading cause of death from gynecologic cancer in women worldwide. According to the National Cancer Institute, ovarian cancer has the highest mortality rate among all the reproductive cancers in women. Advanced stage diagnosis and chemo/radio-resistance is a major obstacle in treating advanced ovarian cancer. The most commonly employed chemotherapeutic drug for ovarian cancer treatment is cis-platin. As with most chemotherapeutic drugs, many patients eventually become resistant to cis-platin and therefore, diminishing its effect. The efficacy of current treatments may be improved by increasing the sensitivity of cancer cells to chemo/radiation therapies. The present study is focused on identifying the differential expression of regulatory microRNAs (miRNAs) between cis-platin sensitive (A2780), and cis-platin resistant (A2780/CP70) cell lines. Cell proliferation assays were conducted to test the sensitivity of the two cell lines to cis-platin. Differential expression patterns of
Objectives: Adherence to National Comprehensive Cancer Network (NCCN) guidelines for ovarian cancer treatment improves patient outcomes. The aim of this study was to assess disparities associated with ovarian cancer treatment in the state of Kentucky and central Appalachia. Methods: Data on patients diagnosed as having ovarian cancer from 2007 through 2011 were extracted from administrative...
The addition of bevacizumab (Avastin) to gemcitabine and carboplatin, followed by bevacizumab until disease progression, resulted in significantly improved progression-free survival compared to gemcitabine and carboplatin plus placebo among women with platinum-sensitive recurrent ovarian, primary periotoneal, or fallopian tube cancer. Results from the phase III OCEANS (Ovarian Cancer Study Comparing the Efficacy and Safety of Chemotherapy and Anti-Angiogenic Therapy in Platinum-Sensitive Recurrent Disease) trial were published in the Journal of Clinical Oncology.1 The study was sponsored by Genentech, which manufactures bevacizumab.. Analysis of Progression-free Survival. Both treatment groups consisted of 242 patients with histologically confirmed disease progression and ≥ 6 months after completion of front-line platinum-based chemotherapy. At the time of the final [progression-free survival] analysis (338 events), the median follow-up was 24 months, the authors reported. The median ...
Ovarian cancer affects the female ovaries, the part of the reproductive system that produces eggs. The cancer cells, in this case, originate in the lining of the ovaries. There are no special ovarian cancer signs and symptoms, but it may produce specific symptoms only when it travels to other nearly tissues and organs, including the pelvis and the stomach.. Last stage ovarian cancer is extremely difficult to treat. Ovarian cancer treatment options include chemotherapy and surgery. For the cancer cases that has spread extensively, a surgery is performed. During ovarian cancer surgery, both the ovaries are removed along with the Fallopian tubes and the uterus. In addition, some abdominal tissues and the nearby lymph nodes may also be removed.. Recovery after ovarian cancer surgery takes a few weeks. The patients is typically required to stay in the hospital for at least a week after the surgery.. ...
Dishevelled family proteins (DVL1, DVL2 and DVL3) are cytoplasmic mediators involved in canonical and non-canonical Wnt signaling that are important for embryonic development. Since Wnt signaling promotes cell proliferation and invasion, its increased activation is associated with cancer development as well. To get deeper insight into the behavior of Dishevelled proteins in cancer, we studied their expression in serous ovarian carcinomas [both low- (LGSC) and high-grade (HGSC)], and HGSC cell lines OVCAR5, OVCAR8 and OVSAHO. DVL protein expression in serous ovarian carcinomas tissues was analyzed using immunohistochemistry while DVL protein and mRNA expressions in HGSC cell lines were analyzed using western blot and quantitative real-time PCR. DVL1 protein expression was significantly higher in LGSC compared with normal ovarian tissue, while DVL3 was overexpressed in both LGSC and HGSC. DVL2 and DVL3 protein expression was higher in HGSC cell lines when compared with normal control cell line ...
A look at the following clinical trial: Young Women Diagnosed With Early Stage Ovarian Cancer: A Focus on Fertility Issues and Sexual Function.
The manganese superoxide dismutase (MnSOD), located in the mitochondria, is a major antioxidant enzyme that plays an important role in protecting cells from oxidative damage. MnSOD has been suggested to have tumor suppressor function in many cancer types. Surprisingly, the levels of MnSOD in ovarian carcinomas were found elevated compared with normal ovarian epithelium. In this study, we aimed to investigate the levels of MnSOD protein in ovarian cancer cell lines and ovarian surface epithelial (OSE) cells and a possible link between MnSOD expression and resistance to apoptosis. We showed that MnSOD protein was abundant in most ovarian cancer cell lines but was at very low levels in OSE. MnSOD overexpression in ovarian cancer cells caused a ~50% decrease of cell proliferation and an increase of apoptosis, whereas targeted inhibition of endogenous MnSOD using small interfering RNA promoted growth of these cells, confirming the effect was MnSOD specific. Furthermore, stimulation of mitochondrial ...
The effective treatment of ovarian serous carcinoma remains a major challenge because of the recurrence of platinum-resistant tumors. The mechanism of platinum-resistance may involve decreased cellular uptake caused by abnormalities of transporters, intracellular cisplatin inactivation (e.g., caused by glutathione), and increased DNA repair (18). However, no available therapy prevents platinum-resistance.. TBX2 is overexpressed by numerous human cancers (7-14). TBX2 may serve as a prognostic factor of breast cancer (7,9), melanoma (8), gastric cancer (10), prostate cancer (11), laryngeal squamous cell carcinoma (12), and non-small cell lung cancer (14). TBX2 is associated with resistance to therapeutic drugs such as cisplatin and doxorubicin (15,16), and TBX2 therefore may serve as a therapeutic target.. One report shows that chromosome 17q12-q24 harbors strong candidates for ovarian tumorigenesis, such as LASP1 (17q12), TGF11 (17q21.32), MUL (17q23.2), TBX2 (17q23.2), AXIN2 (17q24.3), and GRB2 ...
TY - JOUR. T1 - The mTORC2 Component Rictor Contributes to Cisplatin Resistance in Human Ovarian Cancer Cells. AU - Im-aram, Akechai. AU - Farrand, Lee. AU - Bae, Seung Min. AU - Song, Gwonhwa. AU - Song, Yong Sang. AU - Han, Jae Yong. AU - Tsang, Benjamin K.. PY - 2013/9/23. Y1 - 2013/9/23. N2 - Resistance to cisplatin-based therapy is a major cause of treatment failure in human ovarian cancer. A better understanding of the mechanisms of cisplatin resistance will offer new insights for novel therapeutic strategies for this deadly disease. Akt and p53 are determinants of cisplatin sensitivity. Rictor is a component of mTOR protein kinase complex 2, which is required for Akt phosphorylation (Ser473) and full activation. However, the precise role of rictor and the relationship between rictor and p53 in cisplatin resistance remains poorly understood. Here, using sensitive wild-type p53 (OV2008 and A2780s), resistant wild-type p53 (C13* and OVCAR433), and p53 compromised (A2780cp, OCC1, and SKOV-3) ...
Although epithelial ovarian cancers (EOCs) are initially treated with platinum-based chemotherapy, EOCs vary in platinum responsiveness. Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive EOC cell lines is valuable for development of therapeutic strategies to avoid platinum inefficacy and to exploit platinum sensitivity. TOV-21G devoid of FANCF expression, OV-90 and SKOV-3 were employed as examples of platinum-sensitive, platinum-intermediate and platinum-resistant cell lines, respectively. Antineoplastic agents examined included mitomycin C, doxorubicin, etoposide, gemcitabine, chlorambucil, paclitaxel, triapine and X-rays. Their effectiveness against cell lines was analyzed by clonogenic assays. Cytotoxic profiles of mitomycin C and carboplatin were similar, with mitomycin C exhibiting greater potency and selectivity against TOV-21G than carboplatin. Cytotoxic profiles of doxorubicin, etoposide and X-rays overlapped with that of ...
Ovarian Neoplasm Imaging. Springer Science & Business Media. p. 165. ISBN 9781461486336. "NCI Dictionary of Cancer Terms". ... Ovarian teratomas represent about a quarter of ovarian tumors and are typically noticed during middle age. Testicular teratomas ... Treatment of coccyx, testicular, and ovarian teratomas is generally by surgery. Testicular and immature ovarian teratomas are ... Ovarian teratomas often present with abdominal or pelvic pain, caused by torsion of the ovary or irritation of its ligaments. A ...
... is the most common ovarian neoplasm, representing 20% of ovarian neoplasms, and is benign. It has a very superficial ... "Common Causes of Ovarian Enlargement: Ovarian neoplasms". Human Reproduction. University of Utah Medpath. Cheng EJ, Kurman RJ, ... resembling ovarian surface epithelium Ovarian serous cystadenoma accounts for the largest proportion of benign ovarian tumours ... Serous ovarian cystadenocarcinomas account for ~25% of serous tumours. Ovarian cancer Pancreatic serous cystadenoma Serous ...
The ovarian fibroma, also fibroma, is a benign sex cord-stromal tumour. Ovarian fibromas represent 4% of all ovarian neoplasms ... There may be thecomatous areas (fibrothecoma). The presence of an ovarian fibroma can cause ovarian torsion in some cases. ... Vaidya, SA; Kc, S; Sharma, P; Vaidya, S (2014). "Spectrum of ovarian tumors in a referral hospital in Nepal". Journal of ... Diagnosis is usually made by ultrasonography showing a solid ovarian lesion, or, on some occasions, mixed tumors with solid and ...
Sachdeva P, Arora R, Dubey C, Sukhija A, Daga M, Singh DK (April 2008). "Sertoli-Leydig cell tumor: a rare ovarian neoplasm. ... Animal studies a suggest possible link with C8 (C8HF15O2, perfluorooctanoic acid). Presence of an ovarian tumour plus hormonal ... is a member of the sex cord-stromal tumour group of ovarian and testicular cancers. It arises from Leydig cells. While the ... Ovarian cancer, Male genital neoplasia, Rare cancers, Endocrine neoplasia, Endocrine-related cutaneous conditions). ...
v t e (Ovarian cancer, All stub articles, Neoplasm stubs). ... Ovarian cystadenoma is a cystic benign tumor of the ovary. Two ... Limaiem, Faten; Mlika, Mouna (2019). "Ovarian Cystadenoma". StatPearls. StatPearls Publishing. Retrieved 21 November 2019. ...
Relative frequency of primary ovarian neoplasms: a 10-year review. Obstet Gynecol 1989; 74:921. Magrina JF, Espada M, Munoz R, ... In premenopausal women, adnexal masses include ovarian cysts, ectopic (tubal) pregnancies, benign (noncancerous) or malignant ( ... cancerous) tumors, endometriomas, polycystic ovaries, and tubo-ovarian abscess. The most common causes for adnexal masses in ...
... s, or ovarian neoplasms, are tumors arising from the ovary. They can be benign or malignant (ovarian cancer). They ... Ovarian tumors are classified according to the histology of the tumor, obtained in a pathology report. Histology dictates many ... Vaidya, SA; Kc, S; Sharma, P; Vaidya, S (2014). "Spectrum of ovarian tumors in a referral hospital in Nepal". Journal of ... Unless otherwise specified in boxes, reference is: Vaidya, SA; Kc, S; Sharma, P; Vaidya, S (2014). "Spectrum of ovarian tumors ...
"Old abdominal pregnancy presenting as an ovarian neoplasm". Journal of Korean Medical Science. 17 (2): 274-75. doi:10.3346/jkms ... Lithopedia can originate both as tubal and ovarian pregnancies, although tubal pregnancy cases are more common. * After death ... following the rupture of the placental and ovarian membranes; and Lithokelyphopedion ("Stone Sheath [and] Child"), where both ...
A rare ovarian neoplasm. Case report and review of literature". Gynecological Endocrinology. 24 (4): 230-4. doi:10.1080/ ... is a testosterone-secreting ovarian tumor and is a member of the sex cord-stromal tumour group of ovarian and testicular ... Presence of an ovarian tumour plus hormonal disturbances suggests a Sertoli-Leydig cell tumour. However, hormonal disturbance ... "DICER1 Mutations in Familial Multinodular Goiter With and Without Ovarian Sertoli-Leydig Cell Tumors". JAMA. 305 (1): 68-77. ...
It appears in the sex cord-stromal tumour group of ovarian neoplasms. Ovary fibromas are most frequent during middle age, and ... There may be thecomatous areas (fibrothecoma). The presence of an ovarian fibroma can cause ovarian torsion in some cases. ...
... s or theca cell tumors are benign ovarian neoplasms composed only of theca cells. Histogenetically they are classified ... October 2004). "Ovarian thecoma associated in the first trimester of pregnancy". J. Obstet. Gynaecol. Res. 30 (5): 368-71. doi: ... Grossly and microscopically, it consists of the ovarian cortex. Microscopically, the tumour cells have abundant lipid-filled ...
... in ovarian neoplasms predicts shorter survival". Human Pathology. 28 (6): 686-692. doi:10.1016/S0046-8177(97)90177-5. PMID ...
"Pancreatic mucinous cystic neoplasm defined by ovarian stroma: demographics, clinical features, and prevalence of cancer". ... Pancreatic mucinous cystic neoplasm (MCN) is a type of cystic lesion that occurs in the pancreas. Amongst individuals ... Intraductal papillary mucinous neoplasm Pancreatic serous cystadenoma Elta, GH; Enestvedt, BK; Sauer, BG; Lennon, AM (April ... Histologic evaluation of MCNs shows mucin-producing columnar epithelial lining, which is surrounded by ovarian-like stroma. ...
"Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens in serous ovarian neoplasms". Clinical Cancer Research. 9 (17): ...
2009). "Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasms". ...
Brenner tumors are an uncommon subtype of the surface epithelial-stromal tumor group of ovarian neoplasms. The majority are ... Histologically, Leydig cell tumors of the testes and ovarian stromal Leydig cell tumors (ovarian hyperandrogenism and ... Histology at University of Utah (Articles with short description, Short description is different from Wikidata, Ovarian cancer) ... the ovarian granulosa cell tumor, with the fluid-filled spaces Call-Exner bodies between the granulosa cells. Transitional cell ...
... s are a class of ovarian neoplasms that may be benign or malignant. Neoplasms in this group are ... One rare but noteworthy condition associated with mucinous ovarian neoplasms is pseudomyxoma peritonei. As primary ovarian ... For more general information, see ovarian cancer. Research suggests that in the first line treatment of Endometrial Ovarian ... of all ovarian neoplasms In some cases mucinous tumors are characterized by more cysts of variable size and a rarity of surface ...
Sertoli-Leydig cell tumour is part of the sex cord-stromal tumour group of ovarian neoplasms. These tumors produce both Sertoli ...
Laparoscopy may be an option if the surgeon is particularly skilled in removing ovarian neoplasms via laparoscopy intact. If ... A gonadoblastoma is a complex neoplasm composed of a mixture of gonadal elements, such as large primordial germ cells, immature ...
"A case of ovarian metastasis of gallbladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of ... ovarian stroma and testis. The NCI Thesaurus identifies the following types of signet ring cell Castration cell, a non- ...
Immunohistochemistry may help in diagnosing Krukenberg tumors from primary ovarian neoplasms but needs to be applied with ... In most countries, cancer that has metastasized to the ovary accounts for only about 1 to 2% of ovarian cancer; in the ... Krukenberg tumors can occasionally provoke a reaction of the ovarian stroma which leads to hormone production, that results in ... Papakonstantinou E, Liapis A, Kairi-Vassilatou E, Iavazzo C, Kleanthis CK, Kondi-Pafiti A (2011). "Virilizing ovarian ...
They are part of the surface epithelial tumor group of ovarian neoplasms (10-20% of which are the endometrioid type). Benign ... Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN gene mutation profiles. PTEN mutations are more ... "Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles". Modern Pathology. 27 (1): 128 ... CTNNB1 mutations are significantly different in low-grade ovarian endometrioid carcinomas (53%) compared with low-grade ...
Of solid tumor neoplasms, ovarian cancer is most likely to provoke eosinophilia, though any other cancer can cause the ... The World Health Organization classifies these disorders into a) Myeloid and lymphoid neoplasms with eosinophilia and ... Reiter A, Gotlib J (2017). "Myeloid neoplasms with eosinophilia". Blood. 129 (6): 704-714. doi:10.1182/blood-2016-10-695973. ...
... trophoblastic neoplasms, and ovarian carcinoma. Moreover, it also has been used as an immunosuppressive drug for various ...
This includes Wilms tumor, rhabdomyosarcoma, Ewing's sarcoma, trophoblastic neoplasm, testicular cancer, and certain types of ... ovarian cancer. It is given by injection into a vein. Most people develop side effects. Common side effects include bone marrow ...
... ovarian neoplasms (malignant or benign), and peritoneal effusions. Atypical mesothelial hyperplasia Herbert, Ronald A.; ... Peritoneal mesothelial hyperplasia can be encountered in inflammatory pelvic disease with tubo-ovarian abscess, ...
Mucinous tumors are part of the surface epithelial-stromal tumor group of ovarian neoplasms, and account for approximately 36% ... Ovarian Cancer. In: Pharmacotherapy: A pathophysiologic approach.8th ed. Dipiro JT, Talbert RL, Yee GC et al., New York: McGraw ... It is well documented that malignancy may be only focally present in mucinous neoplasms of the ovary, so thorough sampling is ... Pseudomyxoma peritonei may present as a result of an ovarian mucinous tumor, however this is a rare cause of this condition, ...
Ovarian serous cystadenoma Pancreatic mucinous cystadenoma Solid pseudopapillary neoplasm Jais B, Rebours V, Malleo G, Salvia R ... mixed serous-endocrine neoplasm, and VHL-associated serous cystic neoplasm. This latter classification scheme is useful because ... Serous cystic neoplasms that have spread ("metastasized") to another organ are considered malignant and are designated "serous ... In contrast to some of the other cyst-forming tumors of the pancreas (such as the intraductal papillary mucinous neoplasm and ...
They can develop further into a variety of other neoplasms, including choriocarcinoma, yolk sac tumor, and teratoma. They occur ... Clear cell ovarian carcinoma is a rare subtype of epithelial ovarian cancer. Those diagnosed with clear cell ovarian carcinoma ... of hereditary epithelial ovarian cancer. Serous ovarian cancer is the most common type of epithelial ovarian cancer and it ... The Risk of Ovarian Malignancy algorithm uses CA-125 levels and HE4 levels to calculate the risk of ovarian cancer; it may be ...
These epigenetic defects occurred in various cancers (e.g. breast, ovarian, colorectal and head and neck). Two or three ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The term neoplasm is a synonym of tumor. Neoplasia denotes the process of the formation of neoplasms/tumors, and the process is ... The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that ...
For example, neoplasms characterized by high-grade features, invasive glands and or signet ring cells, are termed ... Werth in 1884 coined the term pseudomyxoma peritonei, describing it in association with a mucinous ovarian tumor. In 1901 ... Young RH (May 2004). "Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms". Seminars in ... ISBN 978-0-323-35909-2. Sugarbaker PH (January 2006). "New standard of care for appendiceal epithelial neoplasms and ...
"Male Genitals - Prostate Neoplasms". Pathology study images. University of Virginia School of Medicine. Archived from the ... Mutations in BRCA1 and BRCA2 (important risk factors for ovarian cancer and breast cancer in women) have also been implicated. ... PARP inhibitor olaparib is an approved breast/ovarian cancer drug that is undergoing clinical trials. Also in trials for CRPC ...
Several severe adverse health effects, such as an increased incidence of cancers, thyroid diseases, CNS neoplasms, and possibly ... ovarian, lung, colon, and thyroid tissues as the most radiosensitive among women. For example, the FGR 13 has estimated that ... a female fetus may therefore be multigenerational and increase both the daughter's and grandchildren's risks for ovarian cancer ...
They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... "Screening for Ovarian Cancer". U.S. Preventive Services Task Force. 2004. Archived from the original on 23 October 2010. ... Routine screening is not recommended for bladder cancer, testicular cancer, ovarian cancer, pancreatic cancer, or prostate ... ovarian cancer and colorectal cancer. Diagnosing a new cancer in a pregnant woman is difficult, in part because any symptoms ...
... adrenocortical neoplasms, choriocarcinomas, hepatocellular carcinomas, bladder cancers, ovarian serous epithelial cancers, head ... The ovarian cancer patient experienced a 50% decline in the amount of the ovarian cancer marker protein CA-125 in her blood as ... In ovarian cancers, 75% of low malignancy tumors and 65% of invasive ovarian carcinomas are H19 RNA positive. Normal breast ... "Phase 1/2a Study of DTA-H19 in Advanced Stage Ovarian Cancer With Symptomatic Ascites". ClinicalTrials.gov. U.S. National ...
Arrhenoblastoma Cretinism Cushing's syndrome Excess ovarian androgen release syndrome (ovarian SAHA syndrome) Familial ... neoplasms, and cysts are skin lesions that develop from the epidermal layer of the skin. Aberrant basal cell carcinoma ... an overview with emphasis on the myeloid neoplasms". Chem. Biol. Interact. 184 (1-2): 16-20. doi:10.1016/j.cbi.2009.10.009. ... neoplasms invading or aberrantly present in the dermis. Acquired progressive lymphangioma (benign lymphangioendothelioma) Acral ...
One case study indicates that this is due a mesodermal dysplasia in the long bones resulting in ovarian cancer. The incidence ... While chondrosarcoma is the most common form of a secondary malignant bone neoplasm found in cases of Ollier disease, other ... Early detection and consistent and repeated monitoring is important in order to prevent and treat any potential bone neoplasms ... Clinical and radiological evaluations are conducted in order to detect the presence of bone neoplasms or lesions typically ...
Neoplasm Metastasis Cancer Brain tumor Tse V (10 November 2009). "Brain Metastasis". Medscape. Retrieved 13 January 2010. " ... colorectal or ovarian cancers. Brain metastases are most commonly diagnosed within multiple intracranial areas within the ... Percy AK, Elveback LR, Okazaki H, Kurland LT (January 1972). "Neoplasms of the central nervous system. Epidemiologic ... the national survey of intracranial neoplasms". Neurology. 35 (2): 219-26. doi:10.1212/WNL.35.2.219. PMID 3969210. S2CID ...
Later, this agent would also be used to treat lung and ovarian cancers. Cisplatin, a platinum-based compound, was discovered by ... A study of 93 patients with incurable neoplasms". J Natl Med Assoc. 43 (4): 211-240. PMC 2616951. PMID 14850976. Li, MC; Hertz ... to be effective in ovarian cancer therapy. Notably, this agent, although developed by the NCI in partnership with Bristol-Myers ...
Nakamori M, Fu X, Meng F, Jin A, Tao L, Bast RC, Zhang X (July 2003). "Effective therapy of metastatic ovarian cancer with an ... Its expression is also increased in a wide range of other malignant neoplasms. Factor X (F10) is frequently expressed in normal ... It is also overexpressed in some cell lines originating from various malignant neoplasms. Thus, it is highly expressed in ... Some of these proteases are overexpressed in malignant neoplasms. For example, transmembrane serine protease 2 (TMPRSS2), which ...
... ovarian vein embolization Ovarian vein embolization is a same-day treatment, which takes place in an interventional radiology ... such as osteoporosis or underlying neoplasm. Analogous to vertebroplasty, the purpose of sacroplasty is to provide ... "Ovarian Vein Embolization". RadiologyInfo. Radiological Society of North America, Inc. (RSNA). January 23, 2017. Strub WM, ... Pelvic congestion syndrome usually affects women who have previously been pregnant, because the ovarian veins and pelvic veins ...
Another form of actinomycosis is thoracic disease, which is often misdiagnosed as a neoplasm, as it forms a mass that extends ... Joshi C, Sharma R, Mohsin Z. Pelvic actinomycosis: a rare entity presenting as tubo-ovarian abscess. Arch Gynecol Obstet. 2010 ...
Myeloproliferative neoplasms, including acute leukemia, non-Hodgkin lymphoma and multiple myeloma, occurred in 5 of 119 ... Because of its potential side effects such as amenorrhea or ovarian failure, cyclophosphamide is used for early phases of ... As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer ... Bernatsky S, Clarke AE, Suissa S (February 2008). "Hematologic malignant neoplasms after drug exposure in rheumatoid arthritis ...
Zhang H, Zuo Z, Lu X, Wang L, Wang H, Zhu Z (February 2012). "MiR-25 regulates apoptosis by targeting Bim in human ovarian ... MicroRNA expression pattern in intraductal papillary mucinous neoplasm]". The Korean Journal of Gastroenterology = Taehan ...
Lipkin M, Deschner E, Troncale F (1970). "Cell differentiation and the development of colonic neoplasms". CA: A Cancer Journal ... in ovarian cancer, in mesotheliomas, in melanomas, in thyroid tumors in leukemia and in breast cancer. Therapy that influences ... ovarian, cervical and esophageal cancers. There are several non-malignant causes for elevation of thymidine kinase in serum ... "Biochemical measure of the volume doubling time of human pulmonary neoplasms". Cancer. 55 (7): 1530-5. doi:10.1002/1097-0142( ...
... ovarian neoplasms MeSH C04.588.322.455.398 - granulosa cell tumor MeSH C04.588.322.455.464 - luteoma MeSH C04.588.322.455.531 ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588.274.120.250.250 - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ... femoral neoplasms MeSH C04.588.149.721 - skull neoplasms MeSH C04.588.149.721.450 - jaw neoplasms MeSH C04.588.149.721.450.583 ...
Other names for this syndrome include polycystic ovarian syndrome, polycystic ovary disease, functional ovarian ... androgen-secreting neoplasms, and other pituitary or adrenal disorders, should be investigated. History-taking, specifically ... an ovarian volume of at least 10 ml is regarded as an acceptable definition of having polycystic ovarian morphology. rather ... ovarian cysts. These "cysts" are in fact immature ovarian follicles. The follicles have developed from primordial follicles, ...
... full removal of ovarian cysts, and myomectomies (full removal of fibroids), could only be done via laparotomy. Some of these ... cautery of neoplasms, and tubal ligations. When Nezhat began using his new video-laparoscopic technique of operating off the ... cauterizing of neoplasms, biopsies, and tubal ligations. This meant that other, more complicated gynecologic surgical ...
Survivors of childhood cancer are more than 13 times as likely to get a secondary neoplasm during the 30 years after treatment ... Female infertility by chemotherapy appears to be secondary to premature ovarian failure by loss of primordial follicles. This ... Roness H, Kalich-Philosoph L, Meirow D (2014). "Prevention of chemotherapy-induced ovarian damage: possible roles for hormonal ... The most common secondary neoplasm is secondary acute myeloid leukemia, which develops primarily after treatment with ...
These neoplasms were initially regarded as eosinophilias, hypereosinophilias, Myeloid leukemias, myeloproliferative neoplasms, ... of ovarian Papillary serous cystadenocarcinoma (almost all amplifications); ~5% of colorectal cancers (~60 amplifications, 40% ... Unlike many other myeloid neoplasms with eosinophil such as those caused by Platelet-derived growth factor receptor A or ...
sSMC i (5)(p10) is also detected in rare cases of ovarian cancer and very rare cases of breast cancers. The mechanism(s) by ... However, it may also be active in causing birth defects and neoplasms (e.g. tumors and cancers). The sSMC's small size makes it ... Surgical removal of the gonads has been recommended to remove the threat of developing these sSMC-associated neoplasms. Tuner ... Panani AD, Roussos C (April 2006). "Non-random structural chromosomal changes in ovarian cancer: i(5p) a novel recurrent ...
It is likely directly induced by an underlying neoplasm secreting a growth factor. One candidate may be alpha-transforming ... ovarian cancer, uterine cancer, prostate cancer[citation needed], lung cancer and cervical cancer. Other associated underlying ...
... aka Hurthle-Cell Neoplasms). Expression of PAX8 is increased in neoplastic renal tissues, Wilms tumors, ovarian cancer and ... ovarian cancer cells, bladder, prostate, and endometrial carcinomas. Expression of PAX8 is also induced during the development ...
Although most neoplasms can present with fever, malignant lymphoma is by far the most common diagnosis of FUO among the ... ovarian cancer atrial myxoma and Castleman disease. In those with HIV currently being treated with antiretroviral therapy and ... neoplasms. In some cases the fever even precedes lymphadenopathy detectable by physical examination. ADEM (acute disseminated ...
Ovarian extracts were available in the late 1800s and early 1900s, but were inert or had extremely low estrogenic activity and ... "Pharmacology and Clinical Utility of Hormones in Hormone Related Neoplasms". In Alan C. Sartorelli, David G. Johns (eds.). ... Ovarian Function and its Disorders: Diagnosis and Therapy. Springer Science & Business Media. pp. 309-332. doi:10.1007/978-94- ... or primary ovarian failure), amenorrhea, dysmenorrhea, and oligomenorrhea. Estrogens can also be used to suppress lactation ...
Histological typing of ovarian tumours / S. F. Serov, R. E. Scully, in collaboration with L. H. Sobin and pathologists in ten ... The trend of incidence of ovarian cancer was studied, the 5-year survival rate calculated and prognostic factors for survival ...
... Am J Clin ... Keywords: Appendiceal mucinous neoplasm; CDX2; CK20; Dual immunostain; Ovarian mucinous neoplasm; SATB2; Villin. ... with major differential diagnoses including appendiceal mucinous neoplasm (AMN) and ovarian mucinous neoplasm (OMN). Special AT ... Objectives: Determination of the primary site of origin for mucinous neoplasms identified in the peritoneal and/or pelvic ...
We report two rare cases of PMP originating from mucinous primary ovarian neoplasms. The case series discusses the cases of ... Patients were diagnosed to have pseudomyxoma peritonei arising from mucinous ovarian tumors. Patients were referred to the ... is a rare manifestation of primary mucinous neoplasms. ... In fact, most mucinous ovarian neoplasms are benign (4 in 5 ... A Case Report of Pseudomyxoma Peritonei Arising From Primary Mucinous Ovarian Neoplasms Reuben Joseph, Ramprasath Sathiamoorthy ...
Peritoneal cancer neoplasm. Peritoneal cancer tumor markers. Conținutul. *High-grade ovarian serous carcinoma in a young woman ... Out of these, 44 Figure peritoneal cancer neoplasm. Clinical risk profile associated with ovarian cancer Distribution of cases ... Constantin: Detalii noutati Peritoneal cancer age Peritoneal cancer neoplasm ovarian serous carcinoma in a young woman - case ... Peritoneal cancer chances of survival Profilul de risc clinic asociat cancerului ovarian Covor de tenă Ovarian high-grade ...
... From this page you can access all of our websites ... addressing through that online Ovarian Neoplasm Imaging at theory, iteration, media, permission, and MY effectiveness. fairly ...
Ovarian Tumors (Clinical Setting and US). Sep 3, 2016 by admin in GENERAL RADIOLOGY Comments Off on Ovarian Tumors (Clinical ... Imaging of Ovarian Cancer. Sep 3, 2016 by admin in GENERAL RADIOLOGY Comments Off on Imaging of Ovarian Cancer ... and MR of Benign Ovarian Germ Cell Tumours. Sep 3, 2016 by admin in GENERAL RADIOLOGY Comments Off on and MR of Benign Ovarian ... 1 Origin of all different types of ovarian tumors Most consist of ovarian cell types, but testicular (Sertoli cell) and mixed ...
ROMA is promising predictors of epithelial ovarian cancer to replace CA125, but its utilization requires further exploration. ... ROMA is helpful for distinguishing epithelial ovarian cancer from benign pelvic mass. HE4 is not better than CA125 either for ... Neoplasms, Glandular and Epithelial / diagnosis* * Neoplasms, Glandular and Epithelial / metabolism * Ovarian Neoplasms / ... Does risk for ovarian malignancy algorithm excel human epididymis protein 4 and CA125 in predicting epithelial ovarian cancer: ...
Biology of ovarian neoplasia / edited by E. D. Murphy and W. G. Beamer. by Murphy, E. D , Beamer, W. G , International Union ... Therapeutic progress in ovarian cancer, testicular cancer and the sarcomas / edited by A. T. van Oosterom, F. M. Muggia, F. J. ... Histological typing of ovarian tumours / S. F. Serov, R. E. Scully, in collaboration with L. H. Sobin and pathologists in ten ... Ovarian cancer : screening, treatment, and followup. by National Institutes of Health (U.S..) Office of Medical Applications of ...
The incidence of ovarian cancer increased in recent 10 years. Ovarian cancer ind ... Ovarian cancer is the first mortality rate of gynecologic malignancies. ... Ovarian Cancer. *BRCA1 gene, BRCA2 gene, DHPLC, genetic diagnosis. *Ovarian Neoplasms. .map{width:100%;height:300px;margin- ... The incidence of ovarian cancer increased in recent 10 years. Ovarian cancer. indeed is a disease that should be respected, ...
Gynecology Section 17c - Ovarian Neoplasm Introduction and Surface Epithelial Tumors. This content is for Early Access Month to ...
Ovarian neoplasms in childhood and adolescents in Songklanagarind Hospital, February 1983-March 1989. ... Tintara H, Mitarnun W. Ovarian neoplasms in childhood and adolescents in Songklanagarind Hospital, February 1983-March 1989. ... Ovarian tumors in young females under the age of 20 years in Songklanagarind Hospital from February 1983 to March 1989 were ... The total number of patients was 47, with a 4.0 per cent incidence of ovarian tumors in all age groups. Germ cell tumor was the ...
Ovarian Neoplasms - 63 flashcards. Uterine Abnormalities - 41 flashcards. 1st Trimester - 62 flashcards ...
Ovarian Neoplasms. Carcinoma, Ovarian Epithelial. Endocrine Gland Neoplasms. Neoplasms by Site. Neoplasms. Ovarian Diseases. ... Genital Neoplasms, Female. Urogenital Neoplasms. Endocrine System Diseases. Gonadal Disorders. Carcinoma. Neoplasms, Glandular ... Genetic and Rare Diseases Information Center resources: Ovarian Cancer Ovarian Epithelial Cancer ... Platinum Resistant Ovarian Cancer. TTFields. Paclitaxel. Minimal toxicity. TTF. Tumor Treating Fields. Novocure. ...
Ovarian Diseases [‎1]‎. Ovarian Neoplasms [‎7]‎. Ovary [‎4]‎. Overnutrition [‎1]‎. Overweight [‎52]‎. ...
Ovarian Diseases [‎1]‎. Ovarian Neoplasms [‎7]‎. Ovary [‎4]‎. Overnutrition [‎1]‎. Overweight [‎52]‎. ...
International Collaboration on Ovarian Neoplasms 7; SF-36 = 36 item Short Form Survey; SQLQ = Supplementary Quality of Life ... Advanced ovarian cancer. Carboplatin paclitaxel vs carboplatin paclitaxel plus bevacizumab. 1528. 890. EORTC QLQ-OV28. EORTC ... ovarian 28); EQ5D = EuroQol 5 dimension; FACIT-F = Functional Assessment Chronic Illness Therapy, fatigue; FACT = Functional ...
Women with ovarian cancer may have no symptoms or mild symptoms until the disease is in an advanced stage. ... ClinicalTrials.gov: Ovarian Neoplasms (National Institutes of Health) * ClinicalTrials.gov: Peritoneal Neoplasms (National ... Ovarian Cancer Statistics (National Cancer Institute) * What Are the Key Statistics about Ovarian Cancer? (American Cancer ... What is ovarian cancer?. Cancer is a disease in which abnormal cells in the body grow out of control and form a tumor. Ovarian ...
Neoplasm Metastasis. *Neoplasms, Hormone-Dependent. *Ovarian Neoplasms. *Pelvic Neoplasms. *Uterine Neoplasms. *Endometrial ...
The Recurrence and the Overall Survival Rates of Ovarian Serous Borderline Neoplasms With Noninvasive Implants is Time ... Ovarian Metastases of Intestinal-Type Gastric Carcinoma: A Clinicopathologic Study of 4 Cases with Contrasting Features to ... Carcinoma by Any Other Name: Pseudomyxoma Peritonei is not Best Viewed With an Ovarian Perspective. Bradley, Robert F.; ...
Chapter 34: Cervical, Ovarian and Endometrial Neoplasms. Chapter 35: Hormones and Testicular and Prostate Malignancies ...
... of all ovarian neoplasms. They are the most common ovarian germ cell tumor and also the most common ovarian neoplasm in ... Renewed Calls for Fallopian Tube Removal to Avoid Ovarian Cancer * Advanced Ovarian Cancer: 20% Disease-Free Survival at 10 ... Laparoscopic management of ovarian dermoid cysts: a review of 47 cases. Ann Saudi Med. 2004 Sep-Oct. 24(5):357-60. [QxMD ... Germ cell neoplasms of the testis. Am J Surg Pathol. 1993 Nov. 17(11):1075-91. [QxMD MEDLINE Link]. ...
Keywords: Ovarian Neoplasms, Multicellular Spheroids, CDC25A, Drug Resistance, Cell Cycle, and Molecular Targeted Therapy ... Ovarian cancer cells in ascites prefer to aggregate into the multicellular spheroids (MCS) with an inadequate response to ... Sun Y, Li S, Yang L, Zhang D, Zhao Z, Gao J, Liu L. CDC25A Facilitates Chemo-resistance in Ovarian Cancer Multicellular ... Peritoneal metastasis is the most common pathway for the spread of ovarian cancer and one of the major causes of cancer death. ...
... neoplasm cells; ovarian neoplasms; paclitaxel; toxicity testing. Abstract:. ... Epithelial ovarian carcinoma is the most lethal ... esophageal neoplasms; glutamine; human health; liver neoplasms; neoplasm cells; pH; pancreatic neoplasms; pollution; research; ... antineoplastic activity; antineoplastic agents; biosynthesis; breast neoplasms; colorectal neoplasms; humans; lung neoplasms; ... lung neoplasms; neoplasm cells. Abstract:. ... In this study, a series of novel naphthalimide-benzotriazole conjugates (1a-3c) ...
Larsen, M. D., Jolving, L. R., Fedder, J. & Norgard, B. M., 1. Jul 2019, In: Human Reproduction. 34, Suppl. 1, p. 79-80 2 p.. Research output: Contribution to journal › Conference abstract in journal › Research › peer-review ...
Pittsburgh ACTION (Alliance Concentrating on Impacting Ovarian Neoplasms) Consortium. March 1, 2023 ... Facing Ovarian Cancer Facing Ovarian Cancer Coping with a New Diagnosis Treatment Options About Ovarian Cancer Find a Clinical ... An on-going support program for friends of those effected by ovarian cancer. ...
... ovarian neoplasms, congenital malformations. Men: acne, inj site pain, gynecomastia, seborrhea, fatigue. ... Avoid intercourse for women with significant ovarian enlargement after ovulation. Increased risk of ovarian torsion, multi- ... If ovaries are enlarged on last day of therapy, or other evidence of ovarian hyperstimulation syndrome (OHSS) occurs, do not ... Discontinue if evidence of OHSS occurs (eg, excessive number of ovarian follicles seen by serum estradiol levels or ultrasound ...
Rapid diagnosis and intervention are necessary to preserve ovarian function where this is ... blocking adequate blood flow to the ovary.Ovarian torsion is a surgical emergency. ... Ovarian torsion (or adnexal torsion) is a twisting of the ovary and/or fallopian tube on its vascular and ligamentous supports ... Ovarian torsion is a surgical emergency. Rapid diagnosis and intervention are necessary to preserve ovarian function where this ...
Ovarian Neoplasm. ELIGIBILITY Key Inclusion Criteria. Life expectancy ≥12 weeks.. - Patients must have measurable disease per ... Cohort B-4: Histologically confirmed non-mucinous epithelial ovarian, fallopian tube, or primary peritoneal cancer that is ... or ovarian tumors that recurred after or has been refractory to prior therapy (fresh tumor biopsy or an archived sample testing ...
Accurate discrimination between ovarian borderline tumors (BOTs) and malignancies with imaging play an important role in ... management.Purpose: To evaluate the ability of T2-weighted imaging (T2WI)-based radiomics to discriminate ovarian border... ... Ovarian borderline tumors (BOTs) account for approximately 10-15% of epithelial ovarian tumors, with an annual prevalence of ... First, two-sample t-tests were performed to compare MR-based signature values between ovarian BOT and ovarian cancer. Next, the ...
  • Patients were diagnosed to have pseudomyxoma peritonei arising from mucinous ovarian tumors. (cureus.com)
  • The present case report highlights the significant radio-pathologic characteristics of PMP, which originated from mucinous ovarian tumors. (cureus.com)
  • Pseudomyxoma peritonei (PMP) is a rare disease arising from primary mucinous tumors, which are usually appendiceal mucinous epithelial neoplasms and rarely mucinous ovarian tumors [1] . (cureus.com)
  • REVIEW-URI This study was performed to evaluate the clinical risk profile of patients with ovarian tumors who were surgically treated, measuring the survival rate at 5 years. (anvelope-janteauto.ro)
  • Fig. 1 Typical ultrasound images of (a) benign tumors (b) malignant tumors Methods Our proposed system for ovarian tumor classification is presented in Fig. 2. (radiologykey.com)
  • Ovarian tumors in young females under the age of 20 years in Songklanagarind Hospital from February 1983 to March 1989 were evaluated. (who.int)
  • The total number of patients was 47, with a 4.0 per cent incidence of ovarian tumors in all age groups. (who.int)
  • Some other rarer types of ovarian cancer are malignant germ cell tumors and stromal tumors. (medlineplus.gov)
  • Patients with advanced, histologically confirmed pancreatic, breast, non-small-cell lung cancer (NSCLC), gastric, esophageal, head and neck, or ovarian tumors that recurred after or has been refractory to prior therapy (fresh tumor biopsy or an archived sample testing for Nectin-4 expression). (bcan.org)
  • The Two-dimensional and Three-dimensional T2 Weighted Imaging-based Radiomic Signatures Selected for the Preoperative Discrimination of Ovarian Borderline Tumors and Epithelial Cancer. (researchsquare.com)
  • Accurate discrimination between ovarian borderline tumors (BOTs) and malignancies with imaging play an important role in management. (researchsquare.com)
  • To evaluate the ability of T2-weighted imaging (T2WI)-based radiomics to discriminate ovarian borderline tumors (BOTs) from malignancies based on two-dimensional (2D) and three-dimensional (3D) lesion segmentation methods. (researchsquare.com)
  • The T2WI radiomics could achieve a higher accuracy in discriminating ovarian tumors. (researchsquare.com)
  • Dermoid tumors are mature ovarian teratomas, slow-growing germ cell tumors that are almost always benign. (appliedradiology.com)
  • Struma ovarii are ovarian tumors composed of thyroid tissue, with 5-10% being malignant. (appliedradiology.com)
  • Primary ovarian carcinoid tumors are exceptionally rare entities accounting for approximately 0.1% of all ovarian neoplasms. (whiterose.ac.uk)
  • Although there is no established diagnostic framework for primary ovarian carcinoid tumors, this case was diagnosed as a well-differentiated neuroendocrine tumor, Grade 2 (intermediate grade), arising in association with a mature cystic teratoma/dermoid cyst. (whiterose.ac.uk)
  • Biochemistry of Human Cancer focuses on advances in the application of biochemistry to the study of human cancers, such as neoplastic immunoglobulinopathies, cancer of the bladder, tumors of the neural crest, leukemias and lymphomas, and neoplasms of the bone. (elsevier.com)
  • The remaining chapters look at the role of enzymes and immunoglobulins in cancer, the tryptophan metabolism in cancer of the bladder and the carcinoid syndrome, the link between amino acid metabolism and tumors of the neural crest, and the neoplasms of the digestive tract and the accessory organs (pancreas and liver). (elsevier.com)
  • Reduced MAD2 nuclear intensity was associated with a shorter RFS (P = .03), in ovarian tumors of differing histologic subtype (n = 66). (lenus.ie)
  • However, sex cord tumors are the most common ovarian tumor found in these patients. (myriad.com)
  • The specific expression within epithelial ovarian tumors was further confirmed by mRNA analysis. (helsinki.fi)
  • Epithelial cystic tumors account for about 60% of all true ovarian neoplasms. (medscape.com)
  • One third of all ovarian tumors are serous, and two thirds of these serous tumors are benign. (medscape.com)
  • Mucinous epithelial tumors account for approximately 10-15% of all epithelial ovarian neoplasms. (medscape.com)
  • Solid epithelial ovarian tumors are almost invariably malignant. (medscape.com)
  • In this study, we describe characteristic chromosomal alterations in a consecutive series of 96 serous ovarian tumors by comparative genomic hybridization. (elsevier.com)
  • Subserous myomas must be distinguished from ovarian tumors. (gafacom.website)
  • Ameloblastoma is a benign dental tumor mostly found in the mandible, with several variations El ameloblastoma es un tumor odontogénico benigno que se encuentra mayormente en la mandíbula 80%) usually found in the mandible, making up about 1% of tumors in the oral region.2 ameloblastoma . (udea.edu.co)
  • Ovarian cancer is a cancerous tumor that forms in the tissues of an ovary. (medlineplus.gov)
  • Our results suggest that T2WI-based radiomic features were highly correlated with ovarian tumor subtype classification. (researchsquare.com)
  • Preliminary studies have revealed that in the preclinical chicken model, hens develop ovarian tumor naturally at a very high rate that exceeds 25% during 2-4 years of age. (elsevier.com)
  • This report describes a primary ovarian neuroendocrine tumor arising in association with a mature cystic teratoma in a 65 year-old woman. (whiterose.ac.uk)
  • The rate of endometrial cancer diagnosis was significantly higher in women with endometriosis-associated endometrioid ovarian cancer (33%) than in other patients (11%) (p = 0.04) with a 92% concordance between ovarian and endometrial histologic tumor grade. (elsevier.com)
  • Immunohistochemical staining of ovarian tumor tissue arrays showed distinctive cytoplasmic expression pattern only in mucinous carcinomas and suggested differential expression between benign and malignant mucinous neoplasms. (helsinki.fi)
  • Pre- and postmenopausal women are considered to have a high risk of ovarian cancer if they have a personal or family history of ovarian cancer, have or are suspected to have BRCA1 or BRCA2 genetic mutations, or have an elevated CA-125 level (antigen 125-a protein elevated in cancer tumor cells) as measured by a blood test. (medscape.com)
  • We focus on the cost effectiveness of a novel biomarker combination for detecting ovarian tumor malignancy. (avalonecon.com)
  • A recent study investigated the use of novel biomarker combinations of CA125 and other tumor markers, most notably, HE4, an 11 kDa protein that is a precursor to the epididymal secretory protein E4 and is over-expressed in ovarian carcinomas. (avalonecon.com)
  • A pelvic the anthrax toxin is being evaluated as a choice for tumor ultrasonograph showed a left ovarian complex mass meas- cell surface targeting in chemoresistant neoplasms (5). (cdc.gov)
  • Melanotic Neuroectodermal Tumor of Infancy (MNTI) is a rare neoplasm originating from neural crest El Tumor Neuroectodérmico Melanocítico de la Infancia (TNEMI) es una neoplasia infrecuente neuroectodermal tumor of infancy. (udea.edu.co)
  • The proposed research is significant because a positive outcome of this pilot study would lead to further testing of metformin in a population of euglycemic women who are at risk for developing ovarian cancer. (elsevier.com)
  • The trend of incidence of ovarian cancer was studied, the 5-year survival rate calculated and prognostic factors for survival determined. (who.int)
  • Peritoneal cancer neoplasm. (anvelope-janteauto.ro)
  • Constantin: Detalii noutati Peritoneal cancer age Peritoneal cancer neoplasm ovarian serous carcinoma in a young woman - case report and literature review Peritoneal cancer age Peritoneal cancer end stage. (anvelope-janteauto.ro)
  • Most of the patients with malignant disease were multiparous Moreover, from menopausal patients, the higher prevalence was seen at the group between 45 and 55 years old, not being peritoneal cancer neoplasm on the earlier appearance. (anvelope-janteauto.ro)
  • Thus, our study shows the need to create a screening for patients at risk for ovarian cancer which present higher age, multiparity, early menarche, polycystic ovaries association, and higher serum CA marker values. (anvelope-janteauto.ro)
  • The survival rate at five years of folow-up shows a higher incidence peritoneal cancer age peritoneal cancer peritoneal cancer neoplasm stage in patients under 30 years old, probably due to the earlier stages detected. (anvelope-janteauto.ro)
  • Profilul de risc clinic asociat cancerului ovarian Most of the patients with malignant disease were multiparous Moreover, from menopausal patients, the higher prevalence was seen at the group between 45 and 55 years old, not being dependent on the peritoneal cancer while pregnant appearance. (anvelope-janteauto.ro)
  • The peritoneal cancer while pregnant cancer while pregnant peritoneal cancer neoplasm of gynecological pathology was seen in women with polycystic ovaries i. (anvelope-janteauto.ro)
  • Managementul perioperator al unui pacient cu tumoră Krukenberg - studiu de caz Peritoneal cancer with ascites Ovarian high-grade serous carcinoma is a type of malignancy that is rare among young adult women, being more frequent in postmenopausal wo-men. (anvelope-janteauto.ro)
  • Fig. 1 A 83-year-old woman with newly diagnosed left ovarian cancer (SUV max 8.7) Technique for PET/CT Proper patient preparation and scanning protocol are needed for optimal diagnostic accuracy. (radiologykey.com)
  • Risk for Ovarian Malignancy Algorithm (ROMA) and Human epididymis protein 4 (HE4) appear to be promising predictors for epithelial ovarian cancer (EOC), however, conflicting results exist in the diagnostic performance comparison among ROMA, HE4 and CA125. (nih.gov)
  • ROMA is helpful for distinguishing epithelial ovarian cancer from benign pelvic mass. (nih.gov)
  • ROMA is promising predictors of epithelial ovarian cancer to replace CA125, but its utilization requires further exploration. (nih.gov)
  • Therapeutic progress in ovarian cancer, testicular cancer and the sarcomas / edited by A. T. van Oosterom, F. M. Muggia, F. J. Cleton. (who.int)
  • Ovarian cancer : screening, treatment, and followup. (who.int)
  • Ovarian cancer is the first mortality rate of gynecologic malignancies. (knowcancer.com)
  • The incidence of ovarian cancer increased in recent 10 years. (knowcancer.com)
  • Ovarian cancer indeed is a disease that should be respected, however, there were only few of research work focusing on it in Taiwan. (knowcancer.com)
  • To study the mechanisms of carcinogenesis of ovarian cancer will help us understand this disease and develop new strategies of diagnosis and prevention for ovarian cancer in the future. (knowcancer.com)
  • To our present knowledge, carcinogenesis of ovarian cancer has strong correlation with some special genes such as BRCA1 and BRCA2 genes. (knowcancer.com)
  • The incidences of BRCA1 or BRCA2 gene mutation even increase to 30-50% in the population of familial ovarian cancer. (knowcancer.com)
  • Women with BRCA1 gene mutation have 80% to get breast cancer before the age of 70 and 63% of them would get ovarian cancer before the age of 70. (knowcancer.com)
  • It will become a most powerful tool to establish the database of BRCA1 or BRCA2 gene mutation of the ovarian cancer patients in Taiwan, when we can use the technique of DHPLC combining with the direct DNA sequencing. (knowcancer.com)
  • First, we will utilize the new technique of DHPCL with direct DNA sequence to set up the database of BRCA1 and BRCA2 gene mutation of ovarian cancer patients in Taiwan. (knowcancer.com)
  • Second, we would lie to set up the new technique of DHPLC combining with direct DNA sequencing in the genetic diagnosis of ovarian cancer patients for the future clinical service in our hospital. (knowcancer.com)
  • What is ovarian cancer? (medlineplus.gov)
  • What are the types of ovarian cancer? (medlineplus.gov)
  • There are a few different types of ovarian cancer. (medlineplus.gov)
  • These two cancers are similar to ovarian cancer, and they have the same treatments. (medlineplus.gov)
  • So some medical experts also consider those two types as ovarian cancer. (medlineplus.gov)
  • Ovarian cancer happens when there are changes (mutations) in the genetic material (DNA). (medlineplus.gov)
  • Ovarian cancer that is caused by inherited genetic changes is called hereditary ovarian cancer. (medlineplus.gov)
  • There are also certain genetic changes that can raise your risk of ovarian cancer, including changes called BRCA1 and BRCA2 . (medlineplus.gov)
  • Besides genetics, your lifestyle and the environment can affect your risk of ovarian cancer. (medlineplus.gov)
  • Who is more likely to develop ovarian cancer? (medlineplus.gov)
  • Certain people are more likely to develop ovarian cancer. (medlineplus.gov)
  • What are the symptoms of ovarian cancer? (medlineplus.gov)
  • Ovarian cancer may not cause early signs or symptoms. (medlineplus.gov)
  • How is ovarian cancer diagnosed? (medlineplus.gov)
  • Often the only way to know for sure that you have ovarian cancer is by having a biopsy of the tissue. (medlineplus.gov)
  • What are the treatments for ovarian cancer? (medlineplus.gov)
  • Your provider may suggest that you have genetic testing to look for the gene changes that raise the risk for ovarian cancer. (medlineplus.gov)
  • Sun Y, Li S, Yang L, Zhang D, Zhao Z, Gao J, Liu L. CDC25A Facilitates Chemo-resistance in Ovarian Cancer Multicellular Spheroids by Promoting E-cadherin Expression and Arresting Cell Cycles. (jcancer.org)
  • Peritoneal metastasis is the most common pathway for the spread of ovarian cancer and one of the major causes of cancer death. (jcancer.org)
  • Ovarian cancer cells in ascites prefer to aggregate into the multicellular spheroids (MCS) with an inadequate response to chemotherapy. (jcancer.org)
  • In this study, gene expression analysis implicated that ovarian cancer MCS had its unique expression pattern and the cell cycle-related pathways were prominently altered in MCS cells compared to the monolayer adherent cells. (jcancer.org)
  • Loss-of-function studies showed that CDC25A promoted cisplatin-resistance and paclitaxel-resistance and inhibited the drug-induced apoptosis in ovarian cancer MCS. (jcancer.org)
  • Accordingly, addition of NSC95397, a small molecular inhibitor of CDC25A, sensitized the ovarian cancer MCS to chemotherapeutic agents. (jcancer.org)
  • This provides us a novel strategy for the treatment of ovarian cancer peritoneal metastasis and may help improve the overall survival of ovarian cancer patients. (jcancer.org)
  • An on-going support program for friends of those effected by ovarian cancer. (sandyovarian.org)
  • A virtual ovarian cancer support group. (sandyovarian.org)
  • To date, there have been limited MRI radiomics studies concerning ovarian BOT and epithelial cancer categorization. (researchsquare.com)
  • Ovarian cancer is the most lethal gynecological disease affecting women. (elsevier.com)
  • Cancer prevention strategies, therefore, assume a greater importance in reducing the incidence of ovarian cancer. (elsevier.com)
  • Several retrospective surveys have found indirect clinical evidence that metformin intake is correlated with greater survival in cancer patients including ovarian cancer patients. (elsevier.com)
  • However, there are no prospective clinical studies to suggest that metformin intake reduces the incidence and/or severity of ovarian cancer. (elsevier.com)
  • We seek to address this critical gap in knowledge by conducting a pilot preclinical study utilizing a naturally and spontaneously occurring ovarian cancer model. (elsevier.com)
  • Metastatic ovarian cancer cells isolated from the chickens were found to be aggressive and invasive and expressed genes and proteins commonly found in human ovarian cancer cells. (elsevier.com)
  • Ovarian cancer stem cells recovered from ascites formed extensive network of ovospheres and were found to be highly invasive. (elsevier.com)
  • and 2) determine the extent to which metformin affects invasiveness and viability of ovarian cancer stem cells. (elsevier.com)
  • Under the second aim, ovarian cancer stem cells isolated from the hen model will be treated with various levels of metformin. (elsevier.com)
  • Furthermore, this research will utilize ovarian cancer stems cells isolated from hens to test their susceptibility to metformin treatment. (elsevier.com)
  • Our study's objective was to elucidate the role of ovarian cancer microenvironment in regulating the immunosuppressive function of CD11. (researchgate.net)
  • The maximum tolerated dose of DNR-GA3 in nude mice bearing s.c. human ovarian cancer xenografts was 6-10 times higher than that of DNR. (elsevier.com)
  • The anti-tumour effects of DNR-GA3 and DNR were investigated in four different human ovarian cancer xenografts OVCAR-3, FMa, A2780 and MRI-H-207 at a mean tumour size between 100 and 200 mm 3 . (elsevier.com)
  • The book explains the metabolism of purines and pyrimidines in cancer, hypercalcemia in neoplastic disease without evidence of bone metastases, and neoplasms of other organs, such as the pituitary gland, thyroid, testis, and adrenal cortex. (elsevier.com)
  • We have investigated clinical and histologic features of endometriosis-associated endometrioid ovarian cancer using an institutional retrospective database. (elsevier.com)
  • Methods: Patients diagnosed with endometrioid ovarian cancer at our institution were divided into two groups according to the fulfillment or not of Sampson's and Scott's criteria for the detection of endometriosis-associated ovarian cancer. (elsevier.com)
  • Multivariate analysis was performed using the Cox proportional hazards regression model to establish independent factors associated with endometriosis-associated endometrioid ovarian cancer and to identify predictors of survival. (elsevier.com)
  • Conclusions: The analysis of a retrospective endometrioid ovarian cancer database may allow to suggest a 40 molecular, morphological and clinical parallelism between endometrial and endometrioid ovarian cancers. (elsevier.com)
  • Spindle assembly checkpoint protein expression correlates with cellular proliferation and shorter time to recurrence in ovarian cancer. (lenus.ie)
  • Patient and Genetic Counselor Perceptions of In-Person versus Telephone Genetic Counseling for Hereditary Breast/ovarian Cancer. (gwu.edu)
  • The objective of this study was to identify histotype-specific serum biomarkers for mucinous ovarian cancer. (helsinki.fi)
  • The expression level of the candidate gene in serum was compared to the serum CA125 and HE4 levels in a patient cohort of prospectively collected advanced ovarian cancer. (helsinki.fi)
  • Database searches identified REG4 as a potential biomarker with specificity for the mucinous ovarian cancer subtype. (helsinki.fi)
  • Finally, an ELISA based serum biomarker assay demonstrated increased expression only in patients with mucinous ovarian cancer. (helsinki.fi)
  • This study identifies REG4 as a potential serum biomarker for histotype-specific detection of mucinous ovarian cancer and suggests serum REG4 measurement as a non-invasive diagnostic tool for postoperative follow-up of patients with mucinous ovarian cancer. (helsinki.fi)
  • Background: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer. (elsevier.com)
  • Methods: In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. (elsevier.com)
  • The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients. (elsevier.com)
  • On behalf of the Australian Ovarian Cancer Study Group 2016, ' Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer ', Oncotarget , vol. 7, no. 43, pp. 69097-69110. (elsevier.com)
  • Objective To explore the clinical and biological prognostic factors for advanced ovarian cancer patients receiving first-line treatment with carboplatin, paclitaxel, and bevacizumab. (bmj.com)
  • Subiecte ovarian cancer jokes Sex Cervixul face legatura intre papiloma humano laringe si vagin. (etigararunway.ro)
  • Inainte papiloma humano laringe aparitia cancerului, celulele colului cervical se transforma, ovarian cancer jokes numit displazie, si devin celule anormale ale tesutului cervical. (etigararunway.ro)
  • Ovarian cancer natural treatment Research Cures Cancer - Ovarian Cancer - MedscapeTV oxiuri de la ce apar Hpv foot warts treatment ovarian cancer jokes cancer head, human papillomavirus infection deadly hpv virus gyogyitasa. (etigararunway.ro)
  • New Treatments for Ovarian Cancer papilloma on side of tongue Virus del papiloma humano biologia molecular papiloma ovarian cancer jokes se cura si o no, schistosomiasis meaning in tamil cancer sarcoma leg. (etigararunway.ro)
  • Vinil parazitii bad joke Adenom clasifică nemathelminthes hewan coloid icd-9, Metastatic cancer neck icd 10 Uterine cancer awareness month Breast Cancer Ovarian cancer jokes Month - cancer cerebral estadio 4 Afecțiuni tratate Quick Search: To find out which conditions can be treated in a minimally invasive way by interventional radiologists, click on the corresponding section below. (etigararunway.ro)
  • Ovarian cancer natural treatment - fotobiennale. (etigararunway.ro)
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  • Ovarian cancer survivor shares advice for newly diagnosed ovarian cancer patients detoxifierea ovarian cancer jokes natural Once successful, these could be of value to women struggling with infertility or cancer patients who cannot conceive after undergoing radiation or chemotherapy. (etigararunway.ro)
  • Such treatment is, medicamente parazite eficiente, not ovarian cancer jokes for patients who have a risk of malignant cells in their frozen ovarian tissue. (etigararunway.ro)
  • In that case, ovarian tissue cannot be re-implanted because of the chances that their cancer could return. (etigararunway.ro)
  • Oxiuros mickey mouse, μέτρο 13 εξισωτική αποζημίωση Sneaker10 Developing a transplantable artificial ovary with isolated follicles from their tissue could therefore offer ovarian cancer keychain women more possibilities for them to conceive. (etigararunway.ro)
  • Eat ovarian cancer jokes Heal During Cancer Treatment squamous papilloma description Invatam impreuna Alimente cu maxima influenta in prevenirea si vindecarea cancerului ovarian Cancerul ovarian este una dintre cele mai periculoase boli ovarian cancer jokes. (etigararunway.ro)
  • Este a cincea cauza de cancer mortal printre femeile din SUA - o uimitoare cifra de 14 ovarian cancer jokes 23 de femei diagnosticate in fiecare an. (etigararunway.ro)
  • Ovarian cancer jokes 4 Ovarian Cancer Symptoms That Every Woman Needs To Know viermi la copii ca un tratament Vitamin c dysbiosis fulminant human papillomavirus hpv infection, ovarian cancer month vulgaires machins parazite parolele. (etigararunway.ro)
  • What is Ovarian Cancer: 10 things you should know about ovarian cancer - Cancer Research UK unde în corp Ovarian cancer jokes Divertis, duminica, la Pro Tv Apasă pentru a vedea ovarian cancer jokes originală «ultrasound scan» în dicționarul Engleză dictionary. (etigararunway.ro)
  • Ecografia medicală Medical ultrasonography Diagnosticul sonografic ovarian cancer jokes o tehnică de diagnosticare bazată pe ultrasunete utilizată pentru ovarian cancer jokes structurilor interne ale corpului, inclusiv a tendoanelor, mușchilor, articulațiilor, vaselor și organelor interne pentru posibilele ovarian cancer jokes sau leziuni. (etigararunway.ro)
  • High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is the most common and deadliest type of ovarian cancer. (houstonmethodist.org)
  • Elucidating the precise cell(s) of origin of HGSC will be critical for improving the early detection and prevention of ovarian cancer, ultimately reducing ovarian cancer mortality. (houstonmethodist.org)
  • En 11 annees (1er janvier 1998-31 decembre 2008) 9946 patientes ont ete operes dans notre servie dont 29 pour le cancer de l'ovaire soit 0;29. (bvsalud.org)
  • Newer markers for ovarian cancer are on the horizon. (medscape.com)
  • In women desiring future fertility who have stage IA low-risk ovarian cancer, conservative surgical therapy is appropriate, provided that close follow-up can be maintained. (medscape.com)
  • however, improvements in identification of women at high risk for ovarian cancer, as well as improved imaging techniques, have increased the likelihood of early detection. (medscape.com)
  • this is indicative of ovarian cancer. (medscape.com)
  • Guidelines on ovarian cancer screening and diagnosis have been published by a number of professional medical organizations. (medscape.com)
  • The ACR appropriateness criteria does not recommend that women at average risk for ovarian cancer receive screening imaging. (medscape.com)
  • Women at a high risk of ovarian cancer may benefit from screening. (medscape.com)
  • The recommended imaging test to screen for ovarian cancer is ultrasound (US) to visualize the ovaries. (medscape.com)
  • CT and MRI are usually not appropriate for screening women with either average or high risk of ovarian cancer. (medscape.com)
  • Study of Nemvaleukin Alfa in Combination with Pembrolizumab Versus Investigator's Choice Chemotherapy in Patients with Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer. (who.int)
  • A 29-year-old female with von Recklinghausen's disease developed ovarian epithelial cancer. (uab.cat)
  • Bobbie J. Rimel, MD, discusses how PARP inhibitors are deployed across different treatment settings of ovarian cancer, the recent market withdrawal of PARP inhibitors in later-line indications, and ongoing research efforts at Cedars-Sinai Medical Center for patients with ovarian cancer. (onclive.com)
  • Without head-to-head comparative data, testing for the presence of BRCA mutations and homologous recombination-deficient (HRD) status remain the optimal ways to select between the PARP inhibitors olaparib (Lynparza), niraparib (Zejula), or rucaparib (Rubraca) for maintenance treatment of patients with ovarian cancer, according to Bobbie J. Rimel, MD. (onclive.com)
  • My discussion mostly centered on the use of PARP inhibitors in up-front maintenance for patients with ovarian cancer after they have completed their up-front chemotherapy. (onclive.com)
  • For patients who have HRD ovarian cancer as defined by the approved companion diagnostic test, we can use niraparib or olaparib. (onclive.com)
  • According to estimates from the World Health Organization, 8.3 million people worldwide died from cancer and other neoplasms in 2008-about 14% of all deaths. (avalonecon.com)
  • The use of other biomarkers and combinations of biomarkers in the management of ovarian cancer appears very promising. (avalonecon.com)
  • A recent report from the United Kingdom suggests that the use of longitudinal CA-125 values used in combination with subsequent ultrasound evaluation has a high sensitivity and specificity when used in screening for ovarian cancer. (avalonecon.com)
  • When CA-125 is used in combination with other biomarkers (and traditional RMI data) in the detection of ovarian cancer, substantially higher sensitivity can be achieved. (avalonecon.com)
  • HE4 is a useful tool in detecting ovarian cancer due to minimal gene expression or production of HE4 in normal, cancer-free ovarian tissue. (avalonecon.com)
  • For Stage I disease only, HE4 alone had the highest sensitivity for detection of ovarian cancer (46.2% sensitivity at 90% specificity) compared with combinations, particularly at higher levels of specificity. (avalonecon.com)
  • For the pre- and post-menopausal groups combined, the novel combination marker was able to correctly classify 93.8% of patients diagnosed with epithelial ovarian cancer. (avalonecon.com)
  • When a test or testing algorithm is used for population-based ovarian cancer screening, accuracy requirements are highest. (avalonecon.com)
  • News about a long-suspected cause and updated guidelines helped make ovarian cancer this week's top trending clinical topic. (medscape.com)
  • Results from the largest reported investigation to date suggest that the use of powder in the genital area does not increase the risk for ovarian cancer . (medscape.com)
  • Multibillion-dollar lawsuits have argued that baby powder use caused ovarian cancer and asbestos-related mesothelioma . (medscape.com)
  • However, this pooled analysis of data in four large US cohorts found no statistically significant association between the use of powder in the genital area and increased risk for ovarian cancer. (medscape.com)
  • In news more specific to ovarian cancer, the National Comprehensive Cancer Network (NCCN) recently published updates to its guidelines on genetic/familial high-risk assessment for ovarian cancer and breast cancer . (medscape.com)
  • From the possible exclusion of a rumored cause to key information on diagnosis and mortality, significant recent news about ovarian cancer helped make it this week's top trending clinical topic. (medscape.com)
  • Trending Clinical Topic: Ovarian Cancer - Medscape - Jan 17, 2020. (medscape.com)
  • In particular, overactive JAK signalling is linked to the development of cancer-like conditions called myeloproliferative neoplasms (MPNs) - which include polycythemia vera, essential thrombocythemia and primary myelofibrosis - as well as certain acute childhood leukaemias . (edu.au)
  • It then discusses the important biochemical aspects of pulmonary and prostatic neoplasms, including the serum acid and alkaline phosphatase activities of prostatic carcinoma. (elsevier.com)
  • Objective: Due to the increasing prevalence of the benign condition, ovarian carcinoma arising from endometriosis is emerging as a relevant clinical entity with an unclear biological signature. (elsevier.com)
  • Ovarian carcinoma (OC) is the most lethal of the gynecological malignancies, often presenting at an advanced stage. (lenus.ie)
  • The ovarian lesion was sent for further histopathological evaluation, which showed simple, non-stratified, mucinous epithelium with small basally located nuclei lacking cytological atypia, consistent with benign mucinous ovarian cystadenoma (Figure 3 ). (cureus.com)
  • Ovarian neoplasms range from benign to malignant and may be primary or secondary. (appliedradiology.com)
  • We present the case of a 30-year-old woman with findings of massive ovarian oedema on ultrasound imaging, and a discussion and literature review aiming to clarify that this is a benign tumour-like condition which every gynaecologist can encounter and that the most appropriate treatment is conservative surgery. (who.int)
  • These neoplasms can be benign or malignant. (bvsalud.org)
  • Uterine leiomyoma is the most common benign neoplasm of the female genital tract. (gafacom.website)
  • Ovarian torsion (or adnexal torsion) is a twisting of the ovary and/or fallopian tube on its vascular and ligamentous supports, blocking adequate blood flow to the ovary. (bmj.com)
  • Ovarian torsion is a twisting, or torsion, of the ovary around its ligamentous supports. (bmj.com)
  • This can be easily mistaken for neoplasm, in which case the appropriate treatment will be removal of the whole ovary. (who.int)
  • Determination of the primary site of origin for mucinous neoplasms identified in the peritoneal and/or pelvic cavities may be challenging, with major differential diagnoses including appendiceal mucinous neoplasm (AMN) and ovarian mucinous neoplasm (OMN). (nih.gov)
  • Preoperative diagnostics of ovarian neoplasms rely on ultrasound imaging and the serum biomarkers CA125 and HE4. (helsinki.fi)
  • Rapid diagnosis and intervention are necessary to preserve ovarian function where this is clinically appropriate and it is important to maintain fertility. (bmj.com)
  • Most ovarian cancers are caused by genetic changes that happen during your lifetime. (medlineplus.gov)
  • L'objectif de cette étude était de déterminer la fréquence des cancers gynécologiques en pratique oncologique à Lomé et d'en étudier les aspects épidémiologiques et histo-cliniques. (bvsalud.org)
  • Il s'agitd'une étude rétrospective et descriptive portant sur tous les cancers gynécologiques reçus en oncologie entre le 1erJanvier 2016 et le 31 Décembre 2021. (bvsalud.org)
  • ces cancers ont ete diagnostiques au stade avance d'ou les difficultes dans leur prise en charge chirurgicale. (bvsalud.org)
  • En consequence notre objectif a ete d'etudier la place et les caracteres de la chirurgie dans la prise en charge de ces cancers. (bvsalud.org)
  • Together with allergy symptoms such as swelling of lips, tongue, or face or hives in some patients may appear the following conditions: ovarian enlargement presenting as abdominal or pelvic pain, flushing, nausea, vomiting, or diarrhea, blurred vision, headache, abnormal uterine bleeding. (canadianmopharmacy.com)
  • A pelvic ultrasonograph showed a left ovarian complex mass measuring 14 cm x 9 cm x 6 cm as well as a moderate amount of free fluid in the cul-de-sac. (cdc.gov)
  • Tubo-ovarian abscess is an end-stage disease of acute pelvic inflammatory disease(PID). (e-cep.org)
  • Induction of ovulation and pregnancy in patients with functional anovulatory infertility without primary ovarian failure. (oncologynurseadvisor.com)
  • Adnexal masses often are indeterminate at ultrasound, the diagnostic imaging modality of choice in the workup of women with symptoms of such entities, and confirming ovarian etiology can be difficult. (appliedradiology.com)
  • Massive ovarian oedema is an uncommon cause of adnexal mass, first described by Kalstone in 1969 [1-7]. (who.int)
  • Discontinue if evidence of OHSS occurs (eg, excessive number of ovarian follicles seen by serum estradiol levels or ultrasound, abdominal pain). (oncologynurseadvisor.com)
  • Ultrasound examination showed a large left ovarian hypoechoic homogenous solid mass lesion 7 × 6 cm ( Figure 1 ), which showed poor vascularity on colour Doppler scan. (who.int)
  • A detailed study was performed in 14 patients with epithelial ovarian tumours using the satellite probes 33. (edu.au)
  • Somatic changes were evident in approximately 70% of ovarian tumours, the most common being a deletion or reduction in intensity of a band suggesting loss of heterozygosity. (edu.au)
  • Using DNA fingerprint analyis ovarian tumours were shown to be heterogeneous with different DNA patterns observed in different sites in five of eight patients. (edu.au)
  • This study clearly demonstrates that DNA fingerprint analysis is a sensitive method to detect somatic changes in tumour DNA and for investigating the development of clonal heterogeneity in ovarian tumours. (edu.au)
  • We determined the histo-pathological features of surgically removed ovarian tumours. (bvsalud.org)
  • Results: The highest incidence of ovarian tumours was within the age range of 20-45 years. (bvsalud.org)
  • A total of 95 patients with pathologically proven ovarian BOTs and 101 patients with malignancies were retrospectively included in this study. (researchsquare.com)
  • Therefore, preoperative identification of patients with ovarian lesions suspected of being BOTs may be helpful in their management. (researchsquare.com)
  • Patients who are eligible for laparotomy with a midline incision for gynecological neoplasia, including ovarian mass, uterine mass, and cervical lesions, will be recruited. (biomedcentral.com)
  • They comprise less than 0.1% of ovarian neoplasms and are usually found in young patients (average 25 years). (pathologyoutlines.com)
  • patients often present with ovarian torsion. (medscape.com)
  • Her primary ted to the hospital because of a left ovarian mass torsion. (cdc.gov)
  • We report a 40-year-old female patient who was admitted to the hospital because of a left ovarian mass torsion. (cdc.gov)
  • The study suggested left ovarian mass torsion. (cdc.gov)
  • This case highlights the need to develop ovarian diagnostic criteria in this area. (whiterose.ac.uk)
  • Ovarian and testicular neoplasms. (univr.it)
  • Increased risk of ovarian torsion, multi-fetal gestation and births, ectopic pregnancy, spontaneous abortion. (oncologynurseadvisor.com)
  • Ovarian torsion is a surgical emergency. (bmj.com)
  • B. anthracis ovarian mass torsion. (cdc.gov)
  • September 19, 2022) A Case Report of Pseudomyxoma Peritonei Arising From Primary Mucinous Ovarian Neoplasms. (cureus.com)
  • We report two rare cases of PMP originating from mucinous primary ovarian neoplasms. (cureus.com)