Salvage Therapy: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.Radiotherapy, Conformal: Radiotherapy where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators.Radiotherapy: The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.Prostatectomy: Complete or partial surgical removal of the prostate. Three primary approaches are commonly employed: suprapubic - removal through an incision above the pubis and through the urinary bladder; retropubic - as for suprapubic but without entering the urinary bladder; and transurethral (TRANSURETHRAL RESECTION OF PROSTATE).Radiotherapy, Adjuvant: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Radiotherapy Dosage: The total amount of radiation absorbed by tissues as a result of radiotherapy.Prostate-Specific Antigen: A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Adjuvants, Immunologic: Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Radiotherapy, Intensity-Modulated: CONFORMAL RADIOTHERAPY that combines several intensity-modulated beams to provide improved dose homogeneity and highly conformal dose distributions.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Radiotherapy Planning, Computer-Assisted: Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Radiotherapy, High-Energy: Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle.Freund's Adjuvant: An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.Dose Fractionation: Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.Radiation Injuries: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.Radiotherapy, Computer-Assisted: Computer systems or programs used in accurate computations for providing radiation dosage treatment to patients.Radiotherapy, Image-Guided: The use of pre-treatment imaging modalities to position the patient, delineate the target, and align the beam of radiation to achieve optimal accuracy and reduce radiation damage to surrounding non-target tissues.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Limb Salvage: An alternative to amputation in patients with neoplasms, ischemia, fractures, and other limb-threatening conditions. Generally, sophisticated surgical procedures such as vascular surgery and reconstruction are used to salvage diseased limbs.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Radiation Oncology: A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Breast Neoplasms: Tumors or cancer of the human BREAST.Brachytherapy: A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.Radiosurgery: A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Adjuvants, Pharmaceutic: Agents that aid or increase the action of the principle drug (DRUG SYNERGISM) or that affect the absorption, mechanism of action, metabolism, or excretion of the primary drug (PHARMACOKINETICS) in such a way as to enhance its effects.Dose-Response Relationship, Radiation: The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Chemoradiotherapy: Treatment that combines chemotherapy with radiotherapy.Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Nasopharyngeal Neoplasms: Tumors or cancer of the NASOPHARYNX.Rectal Neoplasms: Tumors or cancer of the RECTUM.Lung Neoplasms: Tumors or cancer of the LUNG.Radiation Tolerance: The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Organs at Risk: Organs which might be damaged during exposure to a toxin or to some form of therapy. It most frequently refers to healthy organs located in the radiation field during radiation therapy.Outcome Assessment (Health Care): Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).Radiation-Sensitizing Agents: Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Cranial Irradiation: The exposure of the head to roentgen rays or other forms of radioactivity for therapeutic or preventive purposes.Mastectomy, Segmental: Removal of only enough breast tissue to ensure that the margins of the resected surgical specimen are free of tumor.Neoadjuvant Therapy: Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Particle Accelerators: Devices which accelerate electrically charged atomic or subatomic particles, such as electrons, protons or ions, to high velocities so they have high kinetic energy.Vincristine: An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Dacarbazine: An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Radiometry: The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.Radiation Dosage: The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).Pelvic Neoplasms: Tumors or cancer of the pelvic region.Antineoplastic Agents, Hormonal: Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)Doxorubicin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.Radiation Pneumonitis: Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Mastectomy: Surgical procedure to remove one or both breasts.Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.Radiodermatitis: A cutaneous inflammatory reaction occurring as a result of exposure to ionizing radiation.Recurrence: The return of a sign, symptom, or disease after a remission.Organ Sparing Treatments: Techniques, procedures, and therapies carried out on diseased organs in such a way to avoid complete removal of the organ and preserve the remaining organ function.Neoplasms, Radiation-Induced: Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Heavy Ion Radiotherapy: The use of a heavy ion particle beam for radiotherapy, such as the HEAVY IONS of CARBON.Aluminum Hydroxide: A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.Tamoxifen: One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Palliative Care: Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)Pregnancy Outcome: Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.Treatment Failure: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.Antineoplastic Agents, Alkylating: A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Xerostomia: Decreased salivary flow.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Spinal NeoplasmsGlioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Vinblastine: Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Lymphatic Irradiation: External or interstitial irradiation to treat lymphomas (e.g., Hodgkin's and non-Hodgkin's lymphomas) and lymph node metastases and also some autoimmune diseases, such as rheumatoid arthritis.Radioisotope Teletherapy: A type of high-energy radiotherapy using a beam of gamma-radiation produced by a radioisotope source encapsulated within a teletherapy unit.Bleomycin: A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.Mechlorethamine: A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Laryngectomy: Total or partial excision of the larynx.Antimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Postoperative Care: The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)Pelvis: The space or compartment surrounded by the pelvic girdle (bony pelvis). It is subdivided into the greater pelvis and LESSER PELVIS. The pelvic girdle is formed by the PELVIC BONES and SACRUM.Etoposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.Actuarial Analysis: The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.Cobalt Radioisotopes: Unstable isotopes of cobalt that decay or disintegrate emitting radiation. Co atoms with atomic weights of 54-64, except 59, are radioactive cobalt isotopes.Androgen Antagonists: Compounds which inhibit or antagonize the biosynthesis or actions of androgens.Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Lomustine: An alkylating agent of value against both hematologic malignancies and solid tumors.Mice, Inbred BALB CGlioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)Radiation-Protective Agents: Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.Iridium Radioisotopes: Unstable isotopes of iridium that decay or disintegrate emitting radiation. Ir atoms with atomic weights 182-190, 192, and 194-198 are radioactive iridium isotopes.Carboplatin: An organoplatinum compound that possesses antineoplastic activity.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Thoracic NeoplasmsTesticular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Preoperative Care: Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)Hypopharyngeal Neoplasms: Tumors or cancer of the HYPOPHARYNX.Oropharyngeal Neoplasms: Tumors or cancer of the OROPHARYNX.Osteoradionecrosis: Necrosis of bone following radiation injury.Soft Tissue Neoplasms: Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.Positron-Emission Tomography: An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.DeoxycytidineLymph Node Excision: Surgical excision of one or more lymph nodes. Its most common use is in cancer surgery. (From Dorland, 28th ed, p966)Supratentorial Neoplasms: Primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and BRAIN STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation.Nimustine: Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.Patient Positioning: Moving a patient into a specific position or POSTURE to facilitate examination, surgery, or for therapeutic purposes.Radiopharmaceuticals: Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)Central Nervous System Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.Amputation: The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Ifosfamide: Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.Mastectomy, Modified Radical: Total mastectomy with axillary node dissection, but with preservation of the pectoral muscles.Vaccines: Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.Administration, Intranasal: Delivery of medications through the nasal mucosa.Fiducial Markers: Materials used as reference points for imaging studies.Radiotherapy Setup Errors: Mistakes committed in the preparations for radiotherapy, including errors in positioning of patients, alignment radiation beams, or calculation of radiation doses.Postoperative Period: The period following a surgical operation.Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)Leucovorin: The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.Mucositis: An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).Patient Selection: Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.Seminoma: A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed)Epirubicin: An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.Chemoradiotherapy, Adjuvant: Combined chemotherapy and radiotherapy given to augment some other form of treatment such as surgery. It is commonly used in the therapy of cancer.Proton Therapy: The use of an external beam of PROTONS as radiotherapy.Heavy Ions: Positively-charged atomic nuclei that have been stripped of their electrons. These particles have one or more units of electric charge and a mass exceeding that of the Helium-4 nucleus (alpha particle).Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Skull Base Neoplasms: Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Operative Blood Salvage: Recovery of blood lost from surgical procedures for reuse by the same patient in AUTOLOGOUS BLOOD TRANSFUSIONS. It is collected during (intraoperatively) or after completion of (postoperatively) the surgical procedures.Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Cell Line, Tumor: A cell line derived from cultured tumor cells.Radiation, Ionizing: ELECTROMAGNETIC RADIATION or particle radiation (high energy ELEMENTARY PARTICLES) capable of directly or indirectly producing IONS in its passage through matter. The wavelengths of ionizing electromagnetic radiation are equal to or smaller than those of short (far) ultraviolet radiation and include gamma and X-rays.Vindesine: Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).Stomatitis: INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.Meningeal Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)Nose Neoplasms: Tumors or cancer of the NOSE.Esthesioneuroblastoma, Olfactory: A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.Arthritis, Experimental: ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.Liver Neoplasms: Tumors or cancer of the LIVER.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Rectum: The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.Eye Enucleation: The surgical removal of the eyeball leaving the eye muscles and remaining orbital contents intact.Neck Dissection: Dissection in the neck to remove all disease tissues including cervical LYMPH NODES and to leave an adequate margin of normal tissue. This type of surgery is usually used in tumors or cervical metastases in the head and neck. The prototype of neck dissection is the radical neck dissection described by Crile in 1906.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Oligodendroglioma: A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Taxoids: A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.Reoperation: A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Neoplasm, Residual: Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)Probability: The study of chance processes or the relative frequency characterizing a chance process.
... requirement of salvage chemotherapy, requirement of salvage surgery, requirement of salvage radiotherapy, death from any cause ... The Core Outcomes in Women's Health (CROWN) Initiative is one effort to standardize outcomes. "median overall survival". NCI ... such as surgery or surgery plus adjuvant therapy. In the disease-free survival, the event is relapse rather than death. The ... The occurrence of an individual in a trial having reached may necessitate withdrawal from the trial before the target outcome ...
Adjuvant chemotherapy is given after a local treatment (radiotherapy or surgery). It can be used when there is little evidence ... Salvage chemotherapy or palliative chemotherapy is given without curative intent, but simply to decrease tumor load and ... Completing the course of treatment is an important factor in achieving better treatment outcomes. Similar results were found in ... Such an algorithm was used in the clinical trials cited above and resulted in significantly improved treatment outcomes. ...
Management of prostate cancer
It may be used instead of surgery or after surgery in early stage prostate cancer (adjuvant radiotherapy). Radiation treatments ... Multiple retrospective analyses have demonstrated that overall survival and disease-free survival outcomes are similar between ... Additionally, for men who have already failed salvage radiation treatment and have limited therapeutic options remaining, ... Thompson IM, Tangen CM, Paradelo J (2009). "Adjuvant radiotherapy for pathological T3N0M0 prostate cancer significantly reduces ...
Outcomes depend on a person's age and other health problems as well as how aggressive and extensive the cancer is. Most people ... External beam radiotherapy became more popular as stronger [X-ray] radiation sources became available in the middle of the 20th ... Rane JK, Pellacani D, Maitland NJ (2012). "Advanced prostate cancer-a case for adjuvant differentiation therapy". Nature ... Mouraviev V, Evans B, Polascik TJ (2006). "Salvage prostate cryoablation after primary interstitial brachytherapy failure: a ...
Adjuvant chemotherapy is given after a local treatment (radiotherapy or surgery). It can be used when there is little evidence ... Salvage chemotherapy or palliative chemotherapy is given without curative intent, but simply to decrease tumor load and ... The FOLFOX study also demonstrated an improvement in treatment outcomes. Positive response increased from 46% in the BSA- ... U. Rüther, C. Nunnensiek, H.-J. Schmoll,Secondary Neoplasias following Chemotherapy, Radiotherapy, and Immunosuppression, ...
Kostniakomięsak, wolna encyklopedia
Scandinavian Sarcoma Group Osteosarcoma Study SSG VIII: prognostic factors for outcome and the role of replacement salvage ... Adjuvant therapy of osteosarcoma--A Phase II trial: Southwest Oncology Group study 9139. „Cancer". 100 (4), s. 818-25, Feb 2004 ... Late effects of chemotherapy and radiotherapy in osteosarcoma and Ewing sarcoma patients: the Italian Sarcoma Group Experience ... Limb salvage compared with amputation for osteosarcoma of the distal end of the femur. A long-term oncological, functional, and ...
سرطان پروستات - ویکیپدیا، دانشنامهٔ آزاد
"Positive Outcome of Interim Analysis of pivotal Alpharadin study: Primary endpoint met in Phase III ALSYMPCA study". Press ... External beam radiotherapy became more popular as stronger [X-ray] radiation sources became available in the middle of the 20th ... Mouraviev V, Evans B, Polascik TJ (2006). "Salvage prostate cryoablation after primary interstitial brachytherapy failure: a ... "Expression of X-linked inhibitor of apoptosis protein in human prostate cancer specimens with and without neo-adjuvant hormonal ...
Neutron capture therapy of cancer
2009). "Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in ... The clinical outcome of the cases treated at Harvard-MIT has been summarized by Busse. Although the treatment was well ... This is an important feature that makes BNCT particularly attractive for salvage therapy of patients with a variety of ... 2004). "Combination of boron neutron capture therapy and external beam radiotherapy for brain tumors". International Journal of ...
Adjuvant versus early salvage radiotherapy: outcome of patients with prostate cancer treated with postoperative radiotherapy...
... and salvage radiotherapy (SRT) are two common concepts to enhance biochemical relapse free survival (BCRFS) in patients with ... prostate cancer (PC). We analyzed differences in outcome between ART ...... ... Adjuvant versus early salvage radiotherapy: outcome of patients with prostate cancer treated with postoperative radiotherapy ... Adjuvant (ART) and salvage radiotherapy (SRT) are two common concepts to enhance biochemical relapse free survival (BCRFS) in ...
Long-Term adjuvant, salvage prostate cancer radiotherapy outcomes similar
... Posted November 17, 2015. by Action Radiotherapy & ... Adjuvant and salvage radiotherapy after radical prostatectomy for high-risk prostate cancer is associated with similar long- ... Varian supports Daily Radiotherapy News. As a charity, Action Radiotherapy is entirely reliant on donations to support our work ... 2018 Action Radiotherapy. Web Design by n8tive , about , terms & conditions , privacy , acorrn constitution ...
Treatment outcome for synchronous locoregional failures of nasopharyngeal carcinoma
Proper selection of patients for aggressive salvage treatment and individualization of treatment are important in managing ... long-term disease control and survival after aggressive salvage treatment using surgery with or without combined radiotherapy. ... Treatment outcome for synchronous locoregional failures of nasopharyngeal carcinoma Head Neck. 2003 Jul;25(7):585-94. doi: ... Results: The 3-year relapse-free survival (RFS) rate and disease-specific survival (DSS) rate after salvage treatment or ...
American Urological Association - Adjuvant and Salvage Radiotherapy after Prostatectomy: ASTRO/AUA Guideline
ASTRO/AUA Guideline is to provide a clinical framework for the use of radiotherapy after prostatectomy in patients with and ... ASTRO/AUA Guideline is to provide a clinical framework for the use of radiotherapy after prostatectomy in patients with and ... The purpose of this clinical guideline on Adjuvant and Salvage Radiotherapy after Prostatectomy: ... The purpose of this clinical guideline on Adjuvant and Salvage Radiotherapy after Prostatectomy: ...
Prostate Cancer: Adjuvant & Salvage Radiotherapy Guideline - American Urological Association
ASTRO/AUA Guideline is to provide a clinical framework for the use of radiotherapy after prostatectomy in patients with and ... The purpose of this clinical guideline on Adjuvant and Salvage Radiotherapy after Prostatectomy: ... Reske SN, Moritz S and Kull T: [11C]Choline-PET/CT for outcome prediction of salvage radiotherapy of local relapsing prostate ... Home Guidelines Clinical Guidelines Prostate Cancer: Adjuvant & Salvage Radiotherapy Guideline Adjuvant and Salvage ...
Timing and patterns of recurrences and deaths from prostate cancer following adjuvant pelvic radiotherapy for pathologic stage...
Of these, 46 received adjuvant RT and 113 did not. The RT group generally received 45-50 Gy to the whole pelvis, then a boost ... to the prostate bed (total dose of 55-65 Gy). In the RP group, 62% received neoadjuvant/adjuvant androgen deprivation vs 17% in ... alone or RP plus adjuvant radiotherapy (RT). Between 1970 and 1983, 159 patients underwent RP for newly diagnosed ... Treatment outcome with adjuvant and salvage irradiation after radical prostatectomy for prostate cancer. Urology 1999; 54: 111- ...
Is Radical Prostatectomy Appropriate for Very-High-Risk Prostate Cancer Patients? No. | Cancer Network
Adjuvant and salvage radiotherapy after prostatectomy: AUA/ASTRO Guideline. J Urol. 2013;190:441-9. ... Outcomes of external-beam radiation therapy for prostate cancer: a study of Medicare beneficiaries in three Surveillance, ... Long-term functional outcomes after treatment for localized prostate cancer. N Engl J Med. 2013;368:436-45. ... What are the outcomes of radical prostatectomy for high-risk prostate cancer? Urology. 2010;76:710-4. ...
Prostatic Neoplasms Articles - Results from #250
It remains unclear whether salvage radiotherapy confers equivalent outcomes. Practice guidelines recommend referral to ... radiation oncology within 6 months after prostatectomy to discuss adjuvant and salvage radiotherapy. Published August 4, 2016 ... Adjuvant radiotherapy post-prostatectomy has been shown to benefit patients with adverse pathology. ... We found that different adverse pathologic outcomes and biochemical outcomes were shown according to biopsy pattern although ...
Radiation Oncology Articles
It remains unclear whether salvage radiotherapy confers equivalent outcomes. Practice guidelines recommend referral to ... Adjuvant Radiotherapy Use by US Radiation Oncologists After Radical Cystectomy for Muscle-invasive Bladder Cancer. Historic ... radiation oncology within 6 months after prostatectomy to discuss adjuvant and salvage radiotherapy. Published August 4, 2016 ... Adjuvant radiotherapy post-prostatectomy has been shown to benefit patients with adverse pathology. ...
ASTRO And AUA Joint Guideline For Radiation Therapy After Prostatectomy Highlighted At ASTRO Annual Meeting - Redorbit
The Adjuvant and Salvage Radiotherapy After Prostatectomy: ASTRO/AUA Guideline is jointly copyrighted by ASTRO and the AUA. It ... will serve as a new, living manifesto of both specialties dedication to optimal patient care and outcomes and will be updated ... "The Adjuvant and Salvage Radiotherapy After Prostatectomy: ASTRO/AUA Guideline is an essential tool for every practice as they ... The Adjuvant and Salvage Radiotherapy After Prostatectomy: ASTRO/AUA Guideline will be presented during the ASTRO Guidelines ...
Skipping Radiotherapy After Surgery for Prostate Cancer
... and be followed with observation and early salvage radiotherapy. ... New results suggest that many men could skip radiotherapy ... produces early outcomes that appear to be slightly better than giving adjuvant radiotherapy to all patients. ... These new data include the first results from the largest trial to compare salvage with adjuvant radiotherapy (the RADICALS-RT ... RADICALS-RT is the largest trial so far to compare salvage with adjuvant radiotherapy, Parker noted. It involved 1396 patients ...
Stereotactic Ablative Radiotherapy for Oligometastatic Disease in Liver
In this paper, we described the definition and technical aspects of SABR, clinical outcomes including efficacy and toxicity, ... In recent years, the introduction of stereotactic ablative radiotherapy (SABR) has offered even more intensive tumor dose ... and radiotherapy can lead to permanent local disease control and improve survival. Among these, an advance in radiation therapy ... A 52-year-old male patient had been treated with surgery and postoperative adjuvant chemotherapy for sigmoid colon cancer ( ...
Frontiers | Gaps between Evidence and Practice in Postoperative Radiotherapy for Prostate Cancer: Focus on Toxicities and the...
Similarly, salvage radiotherapy (SRT) can effectively achieve biochemical-control in a significant proportion of patients with ... This might be partly due to concerns with overtreatment inherent to adjuvant approaches, and/or hesitance about causing ... outcomes. We conclude that concerns with side effects should not preclude the recommendation of an effective and curative- ... Similarly, salvage radiotherapy (SRT) can effectively achieve biochemical-control in a significant proportion of patients with ...
Clinical Spotlight Review: TransAnal Minimally Invasive Surgery (TAMIS) - A SAGES Publication
Outcome of transanal endoscopic microsurgery and adjuvant radiotherapy in patients with T2 rectal cancer. Dis Colon Rectum. ... salvage resection after local treatment for early rectal cancer. Dis Colon Rectum. 1995;38:177-81. ... most favorable outcomes were in those pT2 lesions resected with negative margins that went on to receive adjuvant radiotherapy ... Clinical outcomes. In a systematic review of the literature that was published in 2014, thirty-three retrospective studies and ...
Community Academic Profiles - Faculty & Researchers - Stanford Medicine
... hypothesis that a transient course of androgen suppression with salvage or adjuvant RT after prostatectomy improves outcomes ... Radiotherapy after radical prostatectomy: Does transient androgen suppression improve outcomes? 44th Annual Meeting of the ... INTERCURRENT DEATH AFTER HODGKIN DISEASE THERAPY IN RADIOTHERAPY AND ADJUVANT MOPP TRIALS ANNALS OF INTERNAL MEDICINE Hancock, ... BRIEF CHEMOTHERAPY, STANFORD-V, AND ADJUVANT RADIOTHERAPY FOR BULKY OR ADVANCED-STAGE HODGKINS-DISEASE - A PRELIMINARY-REPORT ...
Role of Positron Emission Tomography (PET) in the Setting of Biochemically Recurrent Prostate Cancer | OMICS International
2014) Adjuvant radiotherapy versus wait-and-see after radical prostatectomy: 10-year follow-up of the ARO 96-02/AUO AP 09/95 ... 2007) Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy. J Clin ... Challenges in salvage radiotherapy after prostatectomy. Prostate cancer is the most common solid malignancy in American men ... Outcomes of pet-directed radiotherapy. Surgical series have provided proof of principle for functional PET directed therapy. ...
Youn H Kim, MD | Stanford Medicine Profiles
... and adjuvant HN2 should be administered after a CR to TSEBT. Patients with T2 disease who fail TSEBT or HN2 can be salvaged ... with better outcomes in T2 disease. There was no clinical advantage to adjuvant HN2 as used in our cohort. Second courses of ... Patients will receive low-dose radiotherapy to a single tumor site on days 1 and 2 (2 Gy each day). CpG injections will be ... In T2 disease, both TSEBT and HN2 were as effective as salvage therapy as when utilized as initial therapy. However, salvage ...
Radical Retropubic Prostatectomy for Prostate Cancer: Background, Indications, Contraindications
Bartkowiak D, Bottke D, Wiegel T. Adjuvant radiotherapy or early salvage radiotherapy in pT3R0 or pT3R1 prostate cancer. Curr ... Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy. J Clin Oncol. ... Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trial. JAMA. 2006 Nov 15. 296 (19): ... High-dose salvage intensity-modulated radiotherapy with or without androgen deprivation after radical prostatectomy for rising ...
Pretreatment Alkaline Phosphatase and Epstein-Barr Virus DNA Predict Poor Prognosis and Response to Salvage Radiotherapy in...
M1 stage subdivision and treatment outcome of patients with bone-only metastasis of nasopharyngeal carcinoma. The oncologist. ... One limitation of this study that cannot be neglected is that the application of various adjuvant therapeutic methods may ... In our study, the salvage radiotherapy technique for all patients were intensity modulated radiotherapy (IMRT), and with a dose ... Pretreatment Alkaline Phosphatase and Epstein-Barr Virus DNA Predict Poor Prognosis and Response to Salvage Radiotherapy in ...
Salvage Brachytherapy After External-Beam Irradiation for Prostate Cancer | Cancer Network | The Oncology Journal
Following salvage brachytherapy, up to 98% of these cancers may be locally controlled, and 5-year freedom from second relapse ... A schema is presented, suggesting that it may be possible to identify the patients most likely to benefit from salvage ... Men who have failed external-beam irradiation as the primary treatment are rarely considered for potentially curative salvage ... A significant percentage of these patients have only locally recurrent cancer and are thus candidates for curative salvage ...
Limb salvage surgery in combination with brachytherapy and external beam radiation for high-grade soft tissue sarcomas -...
Tumor site and histotype did not appear to have an impact on outcome. Chemotherapy did not show to have an impact on local or ... While combined treatment of high-grade soft tissue sarcoma with resection and radiotherapy has become an accepted standard, ... Our institutional practice foresees wide surgical resection with adjuvant brachytherapy and external beam radiation. It was the ... Beltrami, G; Rüdiger, H A; Mela, M M; Scoccianti, G; Livi, L; Franchi, A; Campanacci, D A; Capanna, R (2008). Limb salvage ...
Current state of interventional radiotherapy (brachytherapy) education in Italy: results of the INTERACTS survey
Salvage low dose rate brachytherapy for recurrent prostate cancer after external beam radiotherapy: results from a single ... Adjuvant radiotherapy with brachytherapy boost in soft tissue sarcomas. J Contemp Brachytherapy 2017; 9: 256-262. 29. Barbera F ... External-beam radiotherapy and/or HDR brachytherapy in postoperative endometrial cancer patients: clinical outcomes and ... All Italian radiotherapy schools offer BT procedures and training, but there is a wide heterogeneity. Details are shown in ...
Cardiovascular rehabilitation - Trip Database
Adjuvant and Salvage Radiotherapy after Prostatectomy: ASTRO/AUA Guideline 2019 American Urological Association * Tweet this ... and outcome assessments (see the Patient Education and Outcome Measurement: Timing and Data Elements sections). Primary ... Furthermore, recent data from DM cardiovascular outcomes trials have (...) in the risk of incident HF in men and a 4-fold ... Peripheral arterial disease and critical limb ischaemia: still poor outcomes and lack of guideline adherence. Eur Heart J . ...
ureter cancers drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
Radiotherapy, Adjuvant. Tomography, X-Ray Computed. Treatment Outcome. *Hazardous Substances Data Bank. CIS- ... Tsukamoto T, Yonese J, Ishii N, Maezawa T, Fukui I: [Successful salvage chemotherapy with gemcitabine, etoposide and cisplatin ... Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis. Time Factors. Ureter / pathology. ... Adjuvant radiotherapy of 40 Gy was given to the metastatic sites.. *[MeSH-major] Antineoplastic Combined Chemotherapy Protocols ...
malignant ureteral tumor drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
Radiotherapy, Adjuvant. Tomography, X-Ray Computed. Treatment Outcome. *Hazardous Substances Data Bank. CIS- ... Tsukamoto T, Yonese J, Ishii N, Maezawa T, Fukui I: [Successful salvage chemotherapy with gemcitabine, etoposide and cisplatin ... Adjuvant radiotherapy of 40 Gy was given to the metastatic sites.. *[MeSH-major] Antineoplastic Combined Chemotherapy Protocols ... Ureteral Neoplasms / radiotherapy. Vinblastine / administration & dosage. *[MeSH-minor] Biopsy, Needle. Chemotherapy, Adjuvant ...
Celecoxib in Treating Patients With Relapsed Prostate Cancer Following Radiation Therapy or Radical Prostatectomy
Radiotherapy. - See Disease Characteristics. - Prior salvage radiotherapy after prostatectomy allowed. Surgery. - See Disease ... Outcome Measure:. Effect of COX-2 inhibitors on PSA level. Outcome Description:. To study the effect of COX-2 inhibitors on PSA ... More than 6 months since prior adjuvant or neoadjuvant hormonal therapy. - Duration of prior adjuvant or neoadjuvant hormonal ... after radiotherapy. - PSA no greater than 10 ng/mL. PATIENT CHARACTERISTICS:. Age. - Not specified. Performance status. - ECOG ...
Uterine Inversion - Trip Database
Adjuvant and Salvage Radiotherapy after Prostatectomy: ASTRO/AUA Guideline 2019 American Urological Association * Tweet this ... For continuous outcomes, a mean difference or a standardized mean difference (when studies used different scales to measure an ... The risk of adverse outcomes varies inversely with gestational age. The New Ballard Score uses measurements of neuromuscular ... Tulandi T, Murray C, Guralnick M. Adhesion formation and reproductive outcome after myomectomy and second-look laparoscopy. ...
Prostate surgery | Cancer Survivors Network
If existent then you may opt for a combination therapy with neoadjuvant surgery plus adjuvant radiotherapy. Two radicals will ... Regarding radiation treatments outcomes, they all differ depending on the area radiated. You did not share details of your ... Recurrence is highly expected which would require salvage radiation therapy later. In view of the above you may disregard ... I think it better you request an MRI because these items can put your wish of radiotherapy into jeopardy. You need to get more ...
HT duration? - Prostate Cancer
Evets is asking a completely different question: How much adjuvant ADT do I need with my salvage radiotherapy?. We are waiting ... Combining Androgen Deprivation Therapy (ADT) and Salvage Radiation Therapy (SRT) improves outcomes. Also take a look at a ... The reason I raise this issue is that to some extent adjuvant hormone therapy can probably make up for a deficiency in salvage ... You have to finish the full course of adjuvant ADT just like you have to finish the full course of an antibiotic.. Intermittent ...
Image-guided interstitial brachytherapy boost for nasopharyngeal carcinoma: technical aspects
Several attempts have been made to salvage local recurrent disease with various modalities; outcomes of salvage surgical ... Standard therapy for locally advanced NPC is CCRT, followed by adjuvant chemotherapy or induction chemotherapy, followed by ... and the emergence of more sophisticated delivery of external radiotherapy such as intensity-modulated radiation therapy or ... Because of a paucity of reports on HDR-ISBT boost for NPC, only limited clinical outcomes were reported so far. However, a ...
RecurrenceEarly salvage radiotherapyExternal radiotherapyRadiation therapyChemotherapyProstatectomyRadicalBrachytherapyToxicityEBRTResectionSquamous cell carcMetastasesNeoadjuvantSoft tissueMetastasisSurvival outcomesPostoperative radiotherapy for prostate cancerSurgicalProstate-specifiBody RadiotherapyConformal radiotherapyPotentially curative salvage therapyUnderwentClinicalTherapy in patients with glioblastomaTumorPelvicTrial of adjuvantLimbConventional external beam radiothRecurrent prostaMedianPrognosisPrognostic factorsHigh-risk prostate cancerComplicationsDiseaseDefinitiveVersus early salvageBiochemical relapseSurgery and radiotherapyFunctionalAndrogen ablationConclusions
- These cases highlight the clinical importance of imaging the pattern of local prostate cancer recurrence and the potential difficulties that arise due to the altered anatomy in the prostate bed after prostatectomy or radiotherapy. (medworm.com)
- The purpose of this clinical guideline on Adjuvant and Salvage Radiotherapy after Prostatectomy: ASTRO/AUA Guideline is to provide a clinical framework for the use of radiotherapy after prostatectomy in patients with and without evidence of prostate cancer recurrence. (auanet.org)
- 2. Patients with adverse pathologic findings including seminal vesicle invasion, positive surgical margins, and extraprostatic extension should be informed that adjuvant radiotherapy, compared to radical prostatectomy only, reduces the risk of biochemical (PSA) recurrence, local recurrence, and clinical progression of cancer. (auanet.org)
- 3. Physicians should offer adjuvant radiotherapy to patients with adverse pathologic findings at prostatectomy including seminal vesicle invasion, positive surgical margins, or extraprostatic extension because of demonstrated reductions in biochemical recurrence, local recurrence, and clinical progression. (auanet.org)
- 7. Physicians should offer salvage radiotherapy to patients with PSA or local recurrence after radical prostatectomy in whom there is no evidence of distant metastatic disease. (auanet.org)
- To determine the timing and patterns of late recurrence after radical prostatectomy (RP) alone or RP plus adjuvant radiotherapy (RT). (nature.com)
- One of the most controversial topics in urologic oncology is the role of adjuvant therapy after radical prostatectomy (RP) for those patients at high risk for recurrence. (nature.com)
- BARCELONA, Spain - Radiotherapy can be withheld after surgery for prostate cancer and given only if there are signs of biochemical recurrence of disease, instead of being given automatically to all patients. (medscape.com)
- They show that withholding radiotherapy and monitoring men after they have had a prostatectectomy, and giving early salvage radiotherapy (sRT) when the first signs of biochemical recurrence are seen, produces early outcomes that appear to be slightly better than giving adjuvant radiotherapy to all patients. (medscape.com)
- In patients presenting with biochemical recurrence (rising PSA) after prostatectomy, salvage radiation has been reported to achieve an overall biochemical response rate of 50%, translating into a threefold increase in prostate cancer specific survival ( 15 ). (frontiersin.org)
- It was the purpose of this study to determine long-term outcome, prognostic factors for local and systemic recurrence and morbidity in patients with high-grade soft tissue sarcomas of the extremities, who were subjected to this regimen. (uzh.ch)
- In the following, we describe technical aspects of boost HDR-ISBT as dose escalation for NPC patients who respond poorly to the CCRT with EBRT, not salvage HDR-ISBT for tumor persistence or local recurrence. (termedia.pl)
- The salvage group likely has a worse prognosis because they are the patients who failed from a selected group of "watch and wait" patients, whereas the adjuvant group was treated shortly after surgery before they had a sign of recurrence. (oncolink.org)
- PSA doubling time lower than 4 months (p = 0.01) and time from recurrence to salvage EBRT (p = 0.04) were associated with worse chance of biochemical control. (biomedcentral.com)
- The aims of the study were to assess the outcome among patients with early breast cancer operated on with wide local excision who developed a subsequent ipsilateral breast tumor recurrence, and to identify risk factors for uncontrolled local disease. (springer.com)
- Local recurrence after breast-conserving surgery and radiotherapy. (springer.com)
- In a previous study we demonstrated that, based on 11 C/ 18 F-choline positron emission tomography-computerized-tomography as a diagnostic tool, salvage lymph node dissection (LND) plus adjuvant radiotherapy (ART) is feasible for treatment of pelvic/retroperitoneal nodal recurrence of prostate cancer (PCa). (springer.com)
- Details and Download Full Text PDF: Optimal timing of salvage radiotherapy for biochemical recurrence after radical prostatectomy: is ultra-early salvage radiotherapy beneficial? (pubfacts.com)
- The optimal timing of salvage radiotherapy for biochemical recurrence after radical prostatectomy is controversial. (pubfacts.com)
- In particular, the prognostic significance of salvage radiotherapy delivered before a current definition of biochemical recurrence, i.e. ultra-early salvage radiotherapy, is unclear. (pubfacts.com)
- Ultra-early versus early salvage androgen deprivation therapy for post-prostatectomy biochemical recurrence in pT2-4N0M0 prostate cancer. (pubfacts.com)
- Among 855 patients undergoing radical prostatectomy at our institution between 2000 and 2012, we identified 121 with adjuvant-treatment-naïve pT2-4N0M0 prostate cancer who received salvage ADT for biochemical recurrence. (pubfacts.com)
- Impact of Gleason pattern 5 including tertiary pattern 5 on outcomes of salvage treatment for biochemical recurrence in pT2-3N0M0 prostate cancer. (pubfacts.com)
- However, it is undetermined how tertiary GP5 is handled in the new Gleason grade grouping starting in 2016, and its prognostic value in patients undergoing salvage treatment for postoperative biochemical recurrence (BCR) remains unclear. (pubfacts.com)
- Radiotherapy reduces local recurrence rates but periarticular fibrosis may adversely affect joint function. (biomedcentral.com)
- First, the reader should notice that this study selectively excluded the most common consequences of radical prostatectomy-namely, urinary incontinence, erectile dysfunction, and cancer recurrence (by eliminating all patients who received radiotherapy after surgery). (ascopost.com)
- these are actually diagnostic procedures to determine whether a local recurrence has occurred in radiotherapy patients. (ascopost.com)
- To reduce treatment failure, adjuvant treatments have been applied in consideration of clinical and pathologic risk factors for recurrence. (e-roj.org)
- Robot-assisted Radical Prostatectomy After Focal Therapy: Oncological, Functional Outcomes and Predictors of Recurrence. (helsinki.fi)
- The optimal prostate-specific antigen (PSA) level after radical prostatectomy (RP) for defining biochemical recurrence and initiating salvage radiation therapy (SRT) is still debatable. (springer.com)
- The purpose of this study was to compare the estimated health and economic outcomes for adjuvant whole pelvic radiotherapy to no treatment with salvage therapy for recurrence. (duke.edu)
- Cost-effectiveness as measured by cost per recurrence prevented was highly sensitive to the probability of recurrence and the efficacy of adjuvant therapy. (duke.edu)
- Local recurrence rates following treatment with surgery alone (group 1) or surgery and radiotherapy (group 2). (jamanetwork.com)
- Two patients received salvage surgery, and 4 patients received salvage intracavitary radiotherapy after local recurrence. (elsevier.com)
Early salvage radiotherapy4
- This is our new policy - early salvage radiotherapy at the first sign of a rise in PSA," he said. (medscape.com)
- These results support the use of early salvage radiotherapy for PSA failure after radical prostatectomy," Parker said. (medpagetoday.com)
- In comparison with a policy of early salvage radiotherapy, adjuvant radiotherapy did not improve biological progression-free survival or time to further hormone therapy. (medpagetoday.com)
- No survival benefit of ultra-early salvage radiotherapy was demonstrated, whereas delayed salvage radiotherapy was associated with worse outcome as reported in previous studies. (pubfacts.com)
- Patients whose local disease was treated by surgical resection had a 3-year local control rate of 71% compared with 38% by reirradiation using brachytherapy or external radiotherapy. (nih.gov)
- Lack of efficient training system availability for head and neck ISBT, and the emergence of more sophisticated delivery of external radiotherapy such as intensity-modulated radiation therapy or volumetric modulated arc therapy, with the effectiveness of concurrent chemoradiotherapy also contributed to diminished usage of head and neck ISBT. (termedia.pl)
- This document was amended in October 2018, and again in May 2019 to reflect new Level 1 literature that was released since the original publication of the guideline in April 2013 related to the use of hormone therapy with salvage radiation therapy. (auanet.org)
- Effect of modern, high-quality prostate intensity-modulated radiation therapy on outcome: Evidence from a community radiation oncology program. (urotoday.com)
- The aim of the present study was to describe the effects of implementing modern prostate intensity-modulated radiation therapy (M-IMRT) on dosimetry and outcome. (urotoday.com)
- However, technical developments of radiation therapy such as three-dimensional conformal radiotherapy (3D-CRT) and intensity modulated radiation therapy have gradually expanded their role from a palliative to a curative intent, whereby high-dose radiation can be delivered to the tumor more safely without affecting the liver function. (hindawi.com)
- Research activities have involved initial clinical trials of radiation sensitizer and hypoxic cell cytotoxic agents, initial clinical evaluation of the Cyberknife radiosurgical instrument and longitudinal studies of treatment outcomes and late effects of radiation therapy, such as secondary malignancies and radiation associated cardiovascular disease. (stanford.edu)
- In these patients, salvage radiation therapy (SRT) prolongs survival and is indicated as a potentially curative treatment [ 6 ]. (omicsonline.org)
- To evaluate the results of salvage conformal radiation therapy (3DC-EBRT) for patients submitted to radical prostatectomy (RP) who have achieved complete PSA response and who have never been treated with hormonal therapy (HT). (biomedcentral.com)
- The objective of this study is to evaluate the results of biochemical control and to analyze a period free from hormonal therapy after salvage radiation therapy in a selected group of patients who have never been treated before with hormonal therapy and have achieved complete PSA response after RP. (biomedcentral.com)
- The secondary objectives are to evaluate prognostic factors related to the success of the salvage radiation therapy. (biomedcentral.com)
- From August 2002 to December 2004, 79 prostate cancer patients previously treated with radical prostatectomy (RP) were submitted to salvage three-dimensional conformal external beam radiation therapy (3DC-EBRT) due to biochemical failure. (biomedcentral.com)
- What are the benefits and harms of radiation therapy for clinically localized prostate cancer compared with no treatment or no initial treatment in terms of clinical outcomes? (medpagetoday.com)
- How do specific patient characteristics affect the outcomes of thee different forms of radiation therapy? (medpagetoday.com)
- The review encompassed two broad categories of radiation therapy: external beam radiation therapy (including intensity-modulated radiotherapy, conformational radiation, stereotactic body radiation, and proton beam) and brachytherapy (permanent seed implantation and high-dose temporary brachytherapy). (medpagetoday.com)
- In the RADICALS RT trial, after a median 5 years of follow-up, 87 events of biochemical progression occurred among patients treated with adjuvant radiation following surgery compared with 82 events in men who delayed radiation therapy until they had a rising prostate-specific antigen (PSA) level. (medpagetoday.com)
- He and his colleagues assigned 699 men to the salvage radiation therapy and 697 to have radiation therapy after prostatectomy. (medpagetoday.com)
- The conclusion was similar to that of the RADICALS RT study alone, that withholding radiation therapy until an early salvage treatment did not worsen any results related to biochemical failure, but did spare more than 60% of the men involved in the studies from having to undergo radiation and its complications. (medpagetoday.com)
- There was an absolute difference of 1% at 5 years in favor of early salvage radiation therapy," Vale reported, "but that was not significant. (medpagetoday.com)
- 9. Gorin MA , Manoharan M, Shah G, Eldefrawy A, Soloway MS. Salvage open radical prostatectomy after failed radiation therapy: a single center experience. (jhu.edu)
- Data from the Radiation Therapy Oncology Group (RTOG) have shown a clear improvement in biochemical control of disease when patients receive a combination of radiotherapy and androgen-suppressive treatment. (medscape.com)
- Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of Radiation Therapy Oncology Group 93-05 protocol," International Journal of Radiation Oncology Biology Physics , vol. 60, no. 3, pp. 853-860, 2004. (hindawi.com)
- The study assessed the use of a combination of clinical factors and genomic classifiers in the Post-Operative Radiation Therapy Outcomes Score (PORTOS). (lww.com)
- Preferred treatment for patients with STS is limb preservation surgery usually in combination with adjuvant preoperative or postoperative radiation therapy [1, 3- (lymphedemapeople.com)
- In the event of positive margins or locally advanced disease found on pathology, adjuvant radiation therapy may offer improved survival. (wikipedia.org)
- We reviewed the records of 43 patients with synchronous locoregional failures of NPC who received salvage treatment or chemotherapy between November 1986 and January 2001. (nih.gov)
- Seventeen patients received surgery for regional and/or local failures with or without combined radiotherapy (ST group), 14 patients received reirradiation to both local and regional disease (RT group), and 12 patients received palliative chemotherapy only (CT group). (nih.gov)
- The 3-year relapse-free survival (RFS) rate and disease-specific survival (DSS) rate after salvage treatment or chemotherapy were 17% and 38%, respectively. (nih.gov)
- In patients with more advanced disease, treatment by reirradiation alone or palliative chemotherapy is largely ineffective and is associated with a poor outcome. (nih.gov)
- As it has a complicated anatomical localization, NPC is considered surgically unresectable, but is sensitive to radiotherapy and chemotherapy. (jcancer.org)
- Combination of radiotherapy and chemotherapy has been proven to provide survival benefits for patients with advanced stage NPC [ 4 ]. (jcancer.org)
- Here we retrospectively analyzed the long-term treatment outcomes and toxicity of radiotherapy for ONB patients for whom computed tomography (CT) and three-dimensional treatment planning was conducted to reappraise the role of radiotherapy in the light of recent advanced technology and chemotherapy. (biomedcentral.com)
- Three patients were Kadish stage B and 14 were stage C. All patients were treated with radiotherapy with or without surgery or chemotherapy. (biomedcentral.com)
- However, a standard strategy of treatment for ONB has not been established, and the optimal radiotherapy dose, the exact role of chemotherapy, and the effectiveness of elective neck dissection are yet to be confirmed. (biomedcentral.com)
- The purpose of this study was to analyze the relationship between treatment modalities, survival, tumor control, and the acute and late toxicity of patients treated for ONB with radiotherapy with or without surgery or chemotherapy. (biomedcentral.com)
- Adjuvant chemotherapy following IBTR treatment did not seem to improve local tumor control. (springer.com)
- Repeat surgical resection for recurrent gliomas after primary surgery, chemotherapy, and radiotherapy is feasible but carries a risk of morbidity. (deepdyve.com)
- Among all patients, 57 (38.5%) received adjuvant chemotherapy either concurrently or sequentially. (e-roj.org)
- Primary radiotherapy (RT) is the treatment of choice for OPSCC at most centers, and over the last decade, the addition of concurrent chemotherapy has led to a significant improvement in survival, but at the cost of increased acute and late toxicity. (biomedcentral.com)
- The goal of this randomized phase II study is to compare QOL, functional outcomes, toxicity profiles, and survival following primary RT (± chemotherapy) vs. TORS (± adjuvant [chemo] RT) in patients with OPSCC. (biomedcentral.com)
- Participants will be randomized in a 1:1 ratio between Arm 1 (RT ± chemotherapy) and Arm 2 (TORS ± adjuvant [chemo] RT). (biomedcentral.com)
- Pathologic high-risk features will be used to determine the requirement for adjuvant radiotherapy +/- chemotherapy. (biomedcentral.com)
- Dr. Horwich said this could reflect a change in treatment practices, as patients who are LVI-positive are now treated with adjuvant chemotherapy more frequently. (asco.org)
- For nonseminomas, retroperitoneal lymph node dissection (RPLND) is an option, as is adjuvant chemotherapy with a single cycle of bleomycin, etoposide, and cisplatin (BEP). (asco.org)
- In patients whose testicular cancer is treated with initial chemotherapy but then relapses, guidelines on salvage therapy are not particularly clear, said Lawrence H. Einhorn, MD, of Indiana University School of Medicine. (asco.org)
- One should never institute salvage chemotherapy unless we are 100% certain that the patient really needs it. (asco.org)
- If relapse does occur, salvage chemotherapy still may not be ideal. (asco.org)
- Adjuvant chemotherapy was performed in 5 patients. (elsevier.com)
- This is complicated by the details of the duration between the diagnosis of the bladder cancer, any treatment thereafter, the response to any neo-adjuvant chemotherapy or BCG intravesical therapy, the time interval before the cystectomy, the stage of the tumor in the bladder, the number of lymph nodes involved or not, total number of lymph nodes removed with density of the positive lymph nodes, lymphovascular invasion etc. (urologistraj.com)
- Adjuvant and salvage radiotherapy after radical prostatectomy for high-risk prostate cancer is associated with similar long-term progression-free and overall survival, according to a new study. (actionradiotherapy.org)
- A systematic review of the literature using the Pubmed, Embase and Cochrane databases (search dates 1/1/90 to 12/15/12) was conducted to identify peer-reviewed publications relevant to the use of radiotherapy after prostatectomy. (auanet.org)
- Congruent with this clinical principle, physicians should regularly monitor PSA after radical prostatectomy to enable early administration of salvage therapies if appropriate. (auanet.org)
- The purpose of this guideline is to provide direction to clinicians and patients regarding the use of radiotherapy after radical prostatectomy in the adjuvant or salvage setting. (auanet.org)
- This guideline amendment incorporates newly-published literature into the original ASTRO/AUA Adjuvant and Salvage Radiotherapy after Prostatectomy Guideline and to provide an updated clinical framework for clinicians. (auanet.org)
- The role of genomic classifiers on post-prostatectomy treatment assignment and its potential for predicting therapeutic outcomes is also discussed in this amended guideline. (auanet.org)
- Predictive Factors and Oncologic Outcome of Downgrade to Pathologic Gleason Score 6⁻7 after Radical Prostatectomy in Patients with Biopsy Gleason Score 8⁻10. (urotoday.com)
- To report pathological outcomes and predictors of adverse pathology in men undergoing radical prostatectomy (RP) after an initial period of active surveillance (AS). (urotoday.com)
- The American Society for Radiation Oncology (ASTRO) will highlight the recently published Adjuvant and Salvage Radiotherapy After Prostatectomy: ASTRO/AUA Guideline during ASTRO's 55th Annual Meeting, September 22-25, 2013, in Atlanta. (redorbit.com)
- The Adjuvant and Salvage Radiotherapy After Prostatectomy: ASTRO/AUA Guideline is a comprehensive review of 324 research articles of English-language publications within the Pubmed, Embase and Cochrane databases, published from January 1, 1990 through December 15, 2012. (redorbit.com)
- Adjuvant radiotherapy (ART) after prostatectomy for patients with high-risk features [extracapsular extension (ECE), seminal vesicle invasion (SVI), and positive margin] has been shown to be associated with improved biochemical disease-free survival in three large randomized trials and with improved overall survival in one. (frontiersin.org)
- Diagnosis was discussed with the patient and the options for treatment with risks and complications and this included radical prostatectomy, open or robotic, radiotherapy-brachytherapy or external radiation or both, and hormonal therapy. (cancer.org)
- Determine the effect of celecoxib on prostate-specific antigen (PSA) levels in patients with prostate cancer in biochemical relapse after prior definitive radiotherapy or radical prostatectomy. (knowcancer.com)
- Yeh J, Iankov I, Min M, Abdul Rahim MR, Roos D (2018) Post-Prostatectomy Radiotherapy in a Single Tertiary Institution: Outcomes Relating to Pre- Radiotherapy Prostate Specific Antigen. (scitechnol.com)
- Timing of post-radical prostatectomy (RP) radiotherapy (RT) in patients with high risk prostate cancer continues to be debated. (scitechnol.com)
- The study was aimed at solving a controversy about whether it is better to provide prostatectomy patients with adjuvant radiation within 6 months of surgery or to wait until and if they had biochemical failure as noted by rising PSA levels, Parker explained. (medpagetoday.com)
- Gleason pattern 5 (GP5), including tertiary GP5, at radical prostatectomy has reportedly been associated with poorer clinical outcome. (pubfacts.com)
- We retrospectively reviewed 116 patients with pT2-3N0M0 prostate cancer (PC) who received salvage treatment for BCR after radical prostatectomy between 2003 and 2014. (pubfacts.com)
- Adjuvant radiotherapy after prostatectomy have focused on the side effects may include medications, illicit drugs, may report internal urethral discomfort, sometimes tumors, and, in varying hypoechoic solid lesion showing low signal intensity on the. (bvbdallas.org)
- Patients with localized prostate cancer and their physicians considering modern radical prostatectomy or radiotherapy options must be cautious when reviewing findings of this study. (ascopost.com)
- Men with newly diagnosed localized prostate cancer face a decision between prostatectomy and radiotherapy, treatments deemed similarly effective but with well-established trade-offs in terms of treatment-related morbidity. (ascopost.com)
- When a patient is deciding between prostatectomy and radiotherapy, he and his physician are unable to predict whether postprostatectomy radiotherapy will ultimately be needed. (ascopost.com)
- One-third or more of those who undergo a radical prostatectomy will have an indication for adjuvant or salvage radiotherapy. (ascopost.com)
- Patients who are young and healthy enough to receive radical prostatectomy can, in fact, have better "outcomes" than the general noncancer population! (ascopost.com)
- It is difficult to conclude that a radical prostatectomy reduced a patient's risk for second cancers by 20%, and similarly difficult to believe that prostate radiotherapy caused numerous lung cancers as early as 5 years after treatment. (ascopost.com)
- Because around half of all patients do not have recurrences after radical prostatectomy, Karnes said the study was needed to help identify those with aggressive prostate cancers who do-and who could therefore benefit from early postoperative radiotherapy. (lww.com)
- Patients with high PORTOS had marked reductions of metastasis over 10 years from adding radiotherapy to their prostatectomy. (lww.com)
- Adjuvant Radiotherapy Use by US Radiation Oncologists After Radical Cystectomy for Muscle-invasive Bladder Cancer. (urotoday.com)
- Historic trials suggested significant toxicity with adjuvant radiotherapy (ART) after radical cystectomy for muscle-invasive bladder cancer (MIBC). (urotoday.com)
- There exists extensive literature to support consideration of offering patients radical radiotherapy (RT) in the post-RP setting [ 4 ], with the goal of lengthening biochemical failure free survival (bFFS). (scitechnol.com)
- Comparative analysis of prostate-specific antigen free survival outcomes for patients with low, intermediate and high risk prostate cancer treatment by radical therapy. (medscape.com)
- Early stage cervical cancer can be effectively treated with radical hysterectomy or definitive radiotherapy. (e-roj.org)
- Gilligan DSelvin NJ Radical radiotherapy for 28 cases of mucosal melanoma in the nasal cavity and sinuses. (jamanetwork.com)
- What is the expected morbidity of salvage brachytherapy? (cancernetwork.com)
- Our institutional practice foresees wide surgical resection with adjuvant brachytherapy and external beam radiation. (uzh.ch)
- In the field of interventional radiotherapy (brachytherapy - BT), a decline in BT utilization was detected in the 1990's, essentially due to technological improvement of external beam RT. (termedia.pl)
- Stereotactic radiosurgery and hypofractionated radiotherapy offer similar tumor control to brachytherapy via noninvasive means.15,16 In a report by Fogh et al, 147 patients with recurrent high-grade glioma received a median dose of 35 Gy in 10 fractions. (deepdyve.com)
- This can be of great importance for patients undergoing either brachytherapy or 3-dimensional conformal radiotherapy (3D-CRT). (medscape.com)
- Adjuvant radiotherapy was delivered to the whole pelvis or an extended field with or without brachytherapy. (e-roj.org)
- Intraoperative cesium-131 (Cs-131) brachytherapy performed at the time of neurosurgical resection may represent an excellent salvage treatment option. (thejns.org)
- The authors evaluated the outcomes of this novel treatment with permanent intraoperative Cs-131 brachytherapy. (thejns.org)
- In view of that, it is not surprising that the toxicity reported was less in the salvage radiotherapy group, Parker commented. (medscape.com)
- In this paper, we described the definition and technical aspects of SABR, clinical outcomes including efficacy and toxicity, and related parameters after SABR in liver oligometastases from colorectal cancer. (hindawi.com)
- In this review, we will discuss the recent treatment outcome and toxicity following SABR for liver metastases in CRC. (hindawi.com)
- Multimodal therapy including radiotherapy with precise treatment planning based on CT simulation achieved an excellent local control rate with acceptable toxicity and reasonable overall survival for patients with ONB. (biomedcentral.com)
- The authors' initial experience demonstrates that this treatment approach is well tolerated and safe for patients with previously irradiated tumors after failure of more than 1 radiotherapy regimen and that it results in excellent response rates and minimal toxicity. (thejns.org)
- The primary endpoint is QOL score using the M.D. Anderson Dysphagia Inventory (MDADI), with secondary endpoints including survival, toxicity, other QOL outcomes, and swallowing function. (biomedcentral.com)
- Therefore, we report the toxicity and clinical outcomes after postprostatectomy hypofractionated RT. (iitkgp.ac.in)
- 11,Additional support for this treatment approach comes from researchers at Johns Hopkins who have separately reported outcomes for very-high-risk disease treated with RP and with EBRT. (cancernetwork.com)
- Comparisons of 10-year outcomes of men treated with EBRT vs RP show superior DMFS (74% vs 37%), PCSS (82% vs 62%) and OS (64% vs 58%) for the former, despite the fact that those treated with EBRT were older (median age, 65 vs 59 years). (cancernetwork.com)
- 14-Long-term prospectively collected data from the Prostate Cancer Outcomes Study clearly documented higher rates (at 5 years post-treatment) of urinary incontinence (13% vs 4%) and erectile dysfunction (76% vs 72%) in surgically treated patients compared with patients treated with EBRT. (cancernetwork.com)
- QOL data from the Southwest Oncology Group randomized trial of adjuvant radiation showed that the addition of EBRT to RP resulted in more frequent urinary and early bowel symptoms compared with RP alone. (cancernetwork.com)
- They have never received HT and were submitted to salvage 3DC-EBRT. (biomedcentral.com)
- The 5-year results of the RTOG 86-10 trial in patients with bilobar and more severe prostate carcinoma demonstrated that 4 months of total androgen blockade (TAB) in conjunction with conventional external beam radiotherapy (EBRT) was more beneficial than radiotherapy alone. (medscape.com)
- They underscore the need for randomized prospective clinical trials to assess the usefulness of adjuvant EBRT in Grades II and III meningioma so as to define more precisely the subset of patients who may benefit from the addition of adjuvant radiation. (thejns.org)
- Studies that have compared preoperative to postoperative external-beam radiotherapy (EBRT) as part of limb sparing surgery for patients with extremity STS have shown that, while preoperative EBRT allows the use of lower doses and smaller treatment fields, such an approach is associated with increased risk of acute wound healing complications [3, 6, (lymphedemapeople.com)
- However, in selected patients with a finite number of discrete lesions in liver, defined as oligometastatic state, additional local therapies such as surgical resection, radiofrequency ablation, cryotherapy, and radiotherapy can lead to permanent local disease control and improve survival. (hindawi.com)
- While combined treatment of high-grade soft tissue sarcoma with resection and radiotherapy has become an accepted standard, outlines of treatment algorithms remain a matter of debate. (uzh.ch)
- Sector resection with or without postoperative radiotherapy for stage I breast cancer: A randomized trial. (springer.com)
- Although complete resection has been consistently considered to be the treatment of choice for most NSCLC patients with T3 disease, including cases with chest wall invasion, the role of adjuvant treatment following complete surgical resection of early-stage NSCLC has not been fully established [ 4 5 6 ]. (e-roj.org)
- Chemoradiotherapy (CRT), either given before surgical resection as neoadjuvant therapy or after resection as adjuvant therapy, has been postulated to improve these outcomes. (semanticscholar.org)
- OBJECTIVE: To assess the impact of the complete resection of craniopharyngioma (CP) in adults on oncologic and functional outcomes. (bvsalud.org)
- Even after curative resection, prospective randomized adjuvant therapy trials have shown local failure rates ranging from 39-62%, even in the presence of margin negative R0 resection ( 3 - 6 ). (jcancer.org)
- Cross-sectional imaging is useful for planning radiotherapy, surgical drainage or salvage abdomino-perineal resection. (springeropen.com)
Squamous cell carc2
- The status of perineural invasion predicts the outcomes of postoperative radiotherapy in locally advanced esophageal squamous cell carcinoma. (semanticscholar.org)
- METHODS: From 1995 to 2005, 34 patients with superficial thoracic esophageal squamous cell carcinoma without lymph node metastasis were treated with radiotherapy at our institute. (elsevier.com)
- Early result of SABR for liver metastases has promising outcomes and very low complication rates. (hindawi.com)
- Managing patients whose intraparenchymal brain metastases recur after radiotherapy remains a challenge. (thejns.org)
- Thirteen patients with 15 metastases to the brain that recurred after stereotactic radiosurgery and/or whole brain radiotherapy were treated between 2010 and 2015. (thejns.org)
- Usually, metastases affecting humeral diaphysis are managed with intramedullary nailing or plate fixation but, even in case of effective adjuvant therapies, bone healing cannot be expected [ 17 ]. (omicsonline.org)
- Among the 39 patients with high PORTOS (out of an overall cohort of 197) only 5 percent of the 20 men who had radiotherapy had metastases by 10 years postoperatively compared with 63 percent of the 19 patients who did not have radiotherapy. (lww.com)
- He S, Wang Y, Peng H, Yang L, Chen H, Liang S, Lu L, Chen Y. Pretreatment Alkaline Phosphatase and Epstein-Barr Virus DNA Predict Poor Prognosis and Response to Salvage Radiotherapy in Patients with Nasopharyngeal Carcinoma and Metachronous Bone-Only Metastasis. (jcancer.org)
- Secondly, radiotherapy of bone metastasis improves the prognosis of patients with elevated pretreatment serum ALP and plasma EBV DNA. (jcancer.org)
- The bones account for 50% cases of metastasis, and metastasis to bone is associated with a poor prognosis and survival outcomes [ 7 ]. (jcancer.org)
- RESULTS: Both systems significantly predicted biochemical-relapse-free-survival, metastasis-free-survival, and disease-free-survival, while only the NCCN system correlated with local-control in the definitive radiotherapy group. (bvsalud.org)
- In the salvage setting, only the NCCN system significantly predicted biochemical-relapse-free-survival, metastasis-free-survival and disease-free-survival. (bvsalud.org)
- Due to the low risk of metastasis and relative chemoresistance, the use of definitive radiotherapy or perioperative radiotherapy is very important in maintaining local control. (ukprotontherapy.co.uk)
- However, the benefit of radiotherapy was not seen in the 157 patients who had low PORTOS among whom the metastasis rate by 10 years was nearly doubled in those who had radiotherapy-57 percent, as compared with 31 percent among patients having no adjuvant therapy. (lww.com)
- Disease-specific survival outcomes were determined using Kaplan-Meier survival analysis and Cox proportional hazards models. (thejns.org)
- Survival Outcomes of Elderly Patients With Glioblastoma Multiforme in Their 75th Year or Older Treated With Adjuvant Therapy. (edu.au)
- The trial is designed to provide a definitive QOL comparison between the two arms, and to inform the design of an eventual phase III trial for survival outcomes. (biomedcentral.com)
Postoperative radiotherapy for prostate cancer1
- For patients at high risk of local failure, that is, those with positive surgical margins, adjuvant radiotherapy (RT) results in permanent local control in the majority of patients. (nature.com)
- In order to decrease the risk of biochemical failure, particularly in patients with high-risk features (including positive surgical margins, high grade disease, and/or pT3-stage) ( 7 ), postoperative radiotherapy has been studied and shown efficacious. (frontiersin.org)
- Despite low postoperative mortality rates, the long-term outcomes from surgical-based treatment for oesophageal cancer remain poor. (semanticscholar.org)
- However, he emphasized that these men must be monitored closely and salvage radiotherapy must be given "early" - he said that for him, this means when the prostate specific antigen (PSA) levels reach 0.2 ng/mL "at the very max. (medscape.com)
- A schema is presented, suggesting that it may be possible to identify the patients most likely to benefit from salvage treatment based on prostate-specific antigen (PSA) kinetics and other features. (cancernetwork.com)
- ASTRO) consensus panel acknowledged in 1997 that some component of local failure is common in radiotherapy- treated patients with a rising prostate-specific antigen (PSA) level. (cancernetwork.com)
- This is a retrospective review aiming to evaluate the influence of pre-RT prostate specific antigen (PSA) values on postprostatectomy RT outcomes in one Australian center. (scitechnol.com)
Potentially curative salvage therapy2
- We studied pathological outcomes in men who underwent RP after some time on AS. (urotoday.com)
- Importantly, he said in his late-breaker report at the annual congress of the European Society for Medical Oncology , although urinary and bowel adverse events were generally mild, they occurred more frequently among patients who underwent adjuvant radiation following surgery. (medpagetoday.com)
- One hundred and fifteen patients underwent primary laryngectomy, 102 salvage laryngectomy and 25 functional laryngectomy. (authorea.com)
- We retrospectively reviewed the medical records of 148 patients with FIGO IB-IIA uterine cervical cancer who underwent surgery followed by adjuvant RT at the Yonsei Cancer Center between June 1997 and December 2011. (e-roj.org)
- Because atypical and malignant meningiomas underwent WHO reclassification in 2000, the authors carried out an additional analysis of outcomes of these tumors from 2000 to 2008. (thejns.org)
- To update findings on the clinical and biochemical outcomes of radiation therapies for localized prostate cancer. (annals.org)
- Radiotherapy in this setting can be initiated in multiple different clinical scenarios. (scitechnol.com)
- Patients with low-risk of systemic disease may be cured by a salvage local therapy, while those with higher risk of systemic disease may be offered the option of ADT or a clinical trial. (pubmedcentralcanada.ca)
- At first glance, the finding that one-third of radiotherapy patients experienced "hospitalization" as a result of treatment-related morbidity (Figure A in the article) contradicts the clinical experience of most clinicians who treat prostate cancer. (ascopost.com)
- The role of adjuvant therapy in patients with resected non-small cell lung cancer (NSCLC) has been evaluated in many randomized clinical trials and meta-analyses [ 1 2 3 ]. (e-roj.org)
- The results of several phase III clinical trials suggest that the true benefit of combining radiotherapy with androgen blockade may lie in the potentially synergistic effects of the 2 treatments. (medscape.com)
- Clinical outcomes of gamma knife radiosurgery in the salvage treatment of patients with recurrent high-grade glioma," World Neurosurgery , vol. 80, no. 6, pp. 872-878, 2013. (hindawi.com)
- Quoting the new data, Karnes made a strong case for the combined use of genomic classifiers from tumor specimens together with clinical features for predicting prostate cancer response to radiotherapy. (lww.com)
- Using an EHR-based Clinical Data Repository to Determine Prescribing Patterns and Outcomes. (spotidoc.com)
- As part of the Medicare Prescription Drug, Improvement, and Modernization Act of 2003, Congress directed AHRQ to conduct and support research on the comparative outcomes, clinical effectiveness, and appropriateness of pharmaceuticals, devices, and health care services to meet the needs of Medicare, Medicaid, and the State Children s Health Insurance Program (SCHIP). (docplayer.net)
- A Technical Brief provides an overview of key issues related to a clinical intervention or health care service for example, current indications for the intervention, relevant patient population and subgroups of interest, outcomes measured, and contextual factors that may affect decisions regarding the intervention. (docplayer.net)
- In a clinical research trial, a clinical endpoint generally refers to occurrence of a disease, symptom, sign or laboratory abnormality that constitutes one of the target outcomes of the trial, but may also refer to any such disease or sign that strongly motivates the withdrawal of that individual or entity from the trial, then often termed humane (clinical) endpoint. (wikipedia.org)
Therapy in patients with glioblastoma2
- In recent years, the introduction of stereotactic ablative radiotherapy (SABR) has offered even more intensive tumor dose escalation in a few fractions with reduced dose to the adjacent normal liver. (hindawi.com)
- In recent years, the introduction of stereotactic ablative radiotherapy (SABR) has offered even more intensive tumor dose escalation using a hypofractionated regimen with reduced dose to the normal liver, usually below the threshold dose above which severe RILD is observed. (hindawi.com)
- Tumor site and histotype did not appear to have an impact on outcome. (uzh.ch)
- It consists of en-bloc removal of the tumor bearing bone segment, removal of the tumor from the bone, irradiation, and re-implantation back in the body. (bvsalud.org)
- Functional outcome was assessed by Musculoskeletal Tumor Society (MSTS) scoring system. (bvsalud.org)
- Nodal recurrent PCa after primary treatment or after salvage RT of the prostate fossa is considered an unfavourable situation and androgen deprivation is administered as standard therapy in this tumor stage. (springer.com)
- In modern trials of high-grade gliomas, progression-free survival (PFS) remains short at approximately 7 months, with nearly all patients eventually experiencing tumor progression by 36 months.1,2 While the prognosis of low-grade glioma tends to be significantly better than high-grade glioma, at least half of patients with low-grade glioma.3,4 Thus, salvage therapies are commonly used in the majority of glioma patients. (deepdyve.com)
- Adjuvant gamma knife stereotactic radiosurgery at the time of tumor progression potentially improves survival for patients with glioblastoma multiforme," Neurosurgery , vol. 57, no. 4, pp. 684-692, 2005. (hindawi.com)
- Although this approach was reasonably effective at obtaining tumor control, the speech, swallowing and cosmetic outcomes were poor. (biomedcentral.com)
- Patient and tumor characteristics, treatment modalities and complications and functional outcomes (MSTS 1987, TESS), and lymphoedema severity (Stern) were all collected from prospective databases. (lymphedemapeople.com)
- Mean tumor size was 8.1 cm (1.0-35.6 cm). 27% had no adjuvant radiation, 62% had 50 Gy, and 11% received 66 Gy. (lymphedemapeople.com)
- The 5-year results from the European Organization for Research and Treatment of Cancer (EORTC) trial that compared radiotherapy alone for locally advanced disease (T1, T2 grade 3 disease, any T-T4 without pelvic lymph node involvement) with radiotherapy followed by adjuvant androgen ablation for 3 years demonstrated improved outcome, including a survival advantage for the combined modality arm. (medscape.com)
- METHODS: A decision analytic model was created to estimate the costs of adjuvant pelvic radiotherapy versus no adjuvant radiotherapy in patients with intermediate risk endometrial cancer. (duke.edu)
- CONCLUSIONS: Although adjuvant pelvic radiation does not appear to improve survival for intermediate risk endometrial cancer patients, it does prevent recurrences, at a net positive cost compared to no therapy. (duke.edu)
Trial of adjuvant1
- Peripheral arterial disease and critical limb ischaemia: still poor outcomes and lack of guideline adherence. (tripdatabase.com)
- Seventeen patients (mean age 52.5 years) were treated using a standard protocol between January 2009 and June 2012 with three-dimensional conformal neo-adjuvant radiotherapy to a dose of 50 Gy in 25 fractions at a single centre, followed by limb salvage surgery. (biomedcentral.com)
- Limb salvage surgery for malignant tumors of diaphyseal humerus is an operative challenge, where the surgeon has to preserve elbow and hand functions and retain shoulder stability with as much function as possible. (omicsonline.org)
- In the latest decades limb salvage has become treatment of choice also in these patients because it offers both functional and cosmetic advantages [ 5 ]. (omicsonline.org)
- Lymphoedema is a serious complication following limb salvage for extremity soft tissue sarcomas (STSs) for which little is known. (lymphedemapeople.com)
Conventional external beam radioth1
- During the follow-up period (median: 70 months), four of 20 (20 %), nine of 40 (23 %) and seven of 16 (44 %) patients failed biochemically in the ultra-early, early and delayed salvage radiotherapy groups, respectively. (pubfacts.com)
- The median dose of primary radiotherapy was 60 Gy delivered in 30 fractions. (deepdyve.com)
- The median duration of follow-up after salvage treatment was 5 months (range 0.5-18 months). (thejns.org)
- Prognosis of such patients with local relapse is generally dismal due to lack of not safe and effective salvage treatment option for such patients. (termedia.pl)
- Screening exams can improve prognosis in terms of globe sparing and use of less intensive, ocular-salvage treatments in children with a positive family history of retinoblastoma. (uwhealth.org)
- To review the outcome and evaluate the prognostic factors in the treatment of synchronous locoregional failures of nasopharyngeal carcinoma (NPC). (nih.gov)
- To evaluate the outcomes of adjuvant radiotherapy (RT) and to analyze prognostic factors of survival in the International Federation of Gynecology and Obstetrics (FIGO) IB-IIA uterine cervical cancer. (e-roj.org)
- Prognostic risk models may assist in rational drug development by comparing observed outcomes in nonrandomized phase II studies and retrospective data vs. predicted outcomes based on baseline prognostic factors in the context of historically used agents. (frontiersin.org)
- Cox proportional hazards regression was used to identify prognostic factors for outcomes using univariable and multivariable models. (frontiersin.org)
High-risk prostate cancer1
- Fourteen patients (12.5%) had local complications attributed to radiotherapy. (uzh.ch)
- Neo-adjuvant radiotherapy requires lower doses and smaller treatment volumes and therefore has potential benefits for the management of periarticular STS, but has previously been shown to be associated with an increased risk of post-operative wound complications. (biomedcentral.com)
- This study assesses initial outcome and complications after treatment with neo-adjuvant radiotherapy and surgery for patients with periarticular STS. (biomedcentral.com)
- Imaging allows detection of infectious complications, planning of radiotherapy or salvage surgery. (springeropen.com)
- A significant proportion of patients with early stage locoregional failures can still achieve long-term disease control and survival after aggressive salvage treatment using surgery with or without combined radiotherapy. (nih.gov)
- The results suggest that radiotherapy is equally effective whether it is given to all men shortly after surgery or given later to those men with recurrent disease," Parker said in a statement. (medscape.com)
- Three randomized trials from cooperative groups (SWOG-8794, EORTC 22911, and ARO 96-02) have demonstrated significant biochemical disease-free survival improvement with adjuvant radiotherapy for patients with high-risk features ( 8 - 11 ). (frontiersin.org)
- Functional imaging may potentially improve salvage radiotherapy via detection of disease foci which would otherwise be missed by conventional imaging modalities. (omicsonline.org)
- Herein we review the most commonly employed PET radiotracers for prostate cancer (11C-choline, 18F-choline, and 11C-acetate) with particular attention on their ability to identify foci of recurrent disease as well as their utility as a guide for radiotherapy. (omicsonline.org)
- Of the patients who fail to achieve biochemical control, the principle of selecting the best salvage therapy is based upon determining whether the disease is still on the prostate bed or if it has already spread throughout the body. (biomedcentral.com)
- The investigators limited the analysis to reported outcomes for T1 or T2 disease. (medpagetoday.com)
- Uncontrolled local disease (ULD) was defined as the appearance of clinically manifest invasive adenocarcinoma in the remaining breast or on the ipsilateral chest wall which could not be eradicated with salvage treatment during the period of follow-up (2-18 years). (springer.com)
- Uncontrolled local disease is an important outcome measure following breast-conserving surgery. (springer.com)
- It must be the same eye the consensual reaction to contrast material into the collecting system, careful hemostasis, and closure with multiple sexual partners, and untreated, to of patients with cystectomy being reserved for the im training - years pediatric surgery - year survival any primary site of injury and disease specific outcomes were evaluated using quent when adenoma grows cm or more following vaginal delivery. (bvbdallas.org)
- Outcome: 7 free of disease, 3 recurred (2 salvaged with surgery and RT). (wikibooks.org)
- Adjuvant radiotherapy in patients with intermediate risk disease (stage IB, IC, and occult stage II) is controversial. (duke.edu)
- Patents Published: "Method to determine outcome for patients with prostatic disease. (spotidoc.com)
- After chemo-radiotherapy, MRI follow-up provides confident reassessment of therapeutic response, persistent or recurrent disease. (springeropen.com)
- The disease free survival is usually used to analyze the results of the treatment for the localized disease which renders the patient apparently disease free, such as surgery or surgery plus adjuvant therapy. (wikipedia.org)
- Seventeen patients with ONB were treated with definitive intent with radiotherapy at the Department of Radiotherapy, Hokkaido University Hospital between July 1992 and June 2013. (biomedcentral.com)
- PATIENTS AND METHODS: One-thousand-nine-hundred-nine patients treated with definitive (1,074), adjuvant (381), and salvage radiotherapy (454) were analysed. (bvsalud.org)
- CONCLUSION: This analysis confirms the efficacy of both systems in definitive radiotherapy and suggests the utility of the NCCN also in salvage radiotherapy. (bvsalud.org)
- After adjuvant or definitive radiation for pancreas cancer, there are limited conventional treatment options for recurrent pancreas cancer. (jcancer.org)
Versus early salvage1
Surgery and radiotherapy1
- Excellent functional outcomes can be obtained with this treatment strategy. (biomedcentral.com)
- Maximising functional outcome at these sites is challenging. (biomedcentral.com)
- Transoral robotic surgery (TORS) has emerged as a promising alternative treatment, with preliminary case series demonstrating encouraging oncologic, functional, and quality of life (QOL) outcomes. (biomedcentral.com)