Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA 90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.
An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.
A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
Hospital units providing continuous surveillance and care to acutely ill patients.
Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A disease or state in which death is possible or imminent.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
Health care provided to a critically ill patient during a medical emergency or crisis.
Advanced and highly specialized care provided to medical or surgical patients whose conditions are life-threatening and require comprehensive care and constant monitoring. It is usually administered in specially equipped units of a health care facility.
Elements of limited time intervals, contributing to particular results or situations.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The restoration to life or consciousness of one apparently dead. (Dorland, 27th ed)
A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.
Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to WATER-ELECTROLYTE BALANCE. Fluids may be administered intravenously, orally, by intermittent gavage, or by HYPODERMOCLYSIS.
Incision of tissues for injection of medication or for other diagnostic or therapeutic procedures. Punctures of the skin, for example may be used for diagnostic drainage; of blood vessels for diagnostic imaging procedures.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Evaluation procedures that focus on both the outcome or status (OUTCOMES ASSESSMENT) of the patient at the end of an episode of care - presence of symptoms, level of activity, and mortality; and the process (ASSESSMENT, PROCESS) - what is done for the patient diagnostically and therapeutically.
The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Hospitals controlled by agencies and departments of the state government.
The period of confinement of a patient to a hospital or other health facility.
Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
An infant during the first month after birth.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Substances that reduce the growth or reproduction of BACTERIA.
Drugs that are used to reduce body temperature in fever.
Starches that have been chemically modified so that a percentage of OH groups are substituted with 2-hydroxyethyl ether groups.
Proteins prepared by recombinant DNA technology.
A severe, sometimes fatal, disorder of adipose tissue occurring chiefly in preterm or debilitated infants suffering from an underlying illness and manifested by a diffuse, nonpitting induration of the affected tissue. The skin becomes cold, yellowish, mottled, and inflexible.
Hospital department responsible for the administration and provision of immediate medical or surgical care to the emergency patient.
The confinement of a patient in a hospital.
Extracorporeal ULTRAFILTRATION technique without HEMODIALYSIS for treatment of fluid overload and electrolyte disturbances affecting renal, cardiac, or pulmonary function.
A 24-kDa HMGB protein that binds to and distorts the minor grove of DNA.
Solutions having the same osmotic pressure as blood serum, or another solution with which they are compared. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)
A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Planned post-marketing studies of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have been approved for general sale. These studies are often conducted to obtain additional data about the safety and efficacy of a product. This concept includes phase IV studies conducted in both the U.S. and in other countries.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
Infections by bacteria, general or unspecified.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Bleeding or escape of blood from a vessel.
Application of a ligature to tie a vessel or strangulate a part.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
The process of accepting patients. The concept includes patients accepted for medical and nursing care in a hospital or other health care institution.
Continuance of life or existence especially under adverse conditions; includes methods and philosophy of survival.
Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Agents that prevent clotting.
Visible accumulations of fluid within or beneath the epidermis.
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
Removal of toxins or metabolites from the circulation by the passing of blood, within a suitable extracorporeal circuit, over semipermeable microcapsules containing adsorbents (e.g., activated charcoal) or enzymes, other enzyme preparations (e.g., gel-entrapped microsomes, membrane-free enzymes bound to artificial carriers), or other adsorbents (e.g., various resins, albumin-conjugated agarose).
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
Disease having a short and relatively severe course.
Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.
Infection of the lung often accompanied by inflammation.
Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
The act of regarding attentively and studying facts and occurrences, gathering data through analyzing, measuring, and drawing conclusions, with the purpose of applying the observed information to theoretical assumptions. Observation as a scientific method in the acquisition of knowledge began in classical antiquity; in modern science and medicine its greatest application is facilitated by modern technology. Observation is one of the components of the research process.
A subclass of matrix metalloproteinases that are secreted into the pericellular space.
An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Conformity in fulfilling or following official, recognized, or institutional requirements, guidelines, recommendations, protocols, pathways, or other standards.
Services specifically designed, staffed, and equipped for the emergency care of patients.
Procedures which temporarily or permanently remedy insufficient cleansing of body fluids by the kidneys.
Ratings that express, in numerical values, the degree of impairment or abnormality in the function of specific organs.
Inflammation of the lung parenchyma that is caused by bacterial infections.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.
Proteins released by sensitized LYMPHOCYTES and possibly other cells that inhibit the migration of MACROPHAGES away from the release site. The structure and chemical properties may vary with the species and type of releasing cell.
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.
Medical complexes consisting of medical school, hospitals, clinics, libraries, administrative facilities, etc.
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children.
The expenses incurred by a hospital in providing care. The hospital costs attributed to a particular patient care episode include the direct costs plus an appropriate proportion of the overhead for administration, personnel, building maintenance, equipment, etc. Hospital costs are one of the factors which determine HOSPITAL CHARGES (the price the hospital sets for its services).
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Biologically active substances whose activities affect or play a role in the functioning of the immune system.
Hospitals located in metropolitan areas.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.
A scale that assesses the outcome of serious craniocerebral injuries, based on the level of regained social functioning.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.
Substances that reduce or suppress INFLAMMATION.
The return of a sign, symptom, or disease after a remission.
Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Available manpower, facilities, revenue, equipment, and supplies to produce requisite health care and services.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.
Infections with bacteria of the species ESCHERICHIA COLI.
Measurement of oxygen and carbon dioxide in the blood.
The natural enzymatic dissolution of FIBRIN.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.
A disease of humans and animals that resembles GLANDERS. It is caused by BURKHOLDERIA PSEUDOMALLEI and may range from a dormant infection to a condition that causes multiple abscesses, pneumonia, and bacteremia.
A republic in eastern Africa, south of SUDAN and west of KENYA. Its capital is Kampala.
A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.
The study of chance processes or the relative frequency characterizing a chance process.
Any infection which a patient contracts in a health-care institution.
Infections with bacteria of the genus STAPHYLOCOCCUS.
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
The measurement of the health status for a given population using a variety of indices, including morbidity, mortality, and available health resources.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
Bacteria which retain the crystal violet stain when treated by Gram's method.
An abnormal elevation of body temperature, usually as a result of a pathologic process.
Patterns of practice related to diagnosis and treatment as especially influenced by cost of the service requested and provided.
Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
A system for classifying patient care by relating common characteristics such as diagnosis, treatment, and age to an expected consumption of hospital resources and length of stay. Its purpose is to provide a framework for specifying case mix and to reduce hospital costs and reimbursements and it forms the cornerstone of the prospective payment system.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Care provided patients requiring extraordinary therapeutic measures in order to sustain and prolong life.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.
A country in western Europe bordered by the Atlantic Ocean, the English Channel, the Mediterranean Sea, and the countries of Belgium, Germany, Italy, Spain, Switzerland, the principalities of Andorra and Monaco, and by the duchy of Luxembourg. Its capital is Paris.
Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes.. Expert review of anti-infective therapy ... Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2012 (PDF). Critical Care ... 败血症(拉丁语:Sepsis)指的是由於感染所引起的全身性發炎的嚴重疾病[1]。常見的臨床症狀包括發燒、呼吸頻率和心跳加速,以及意識不清[2]。有時患者也會發生特定的臨床症狀,如因肺炎引起
... has not been found to improve outcomes in people with severe sepsis. The manufacturer's aggressive strategies ... Sepsis. Severe sepsis. Septic shock. Multiple organ dysfunction syndrome. Other shock. Cardiogenic shock. Distributive shock. ... Finally, the Surviving Sepsis Campaign was established, in theory to raise awareness of severe sepsis and generate momentum ... In the USA drotrecogin was FDA approved for the reduction of mortality in adult patients with severe sepsis (sepsis associated ...
"Plasma HSPA12B is a potential predictor for poor outcome in severe sepsis". PLOS ONE. 9 (6): e101215. doi:10.1371/journal.pone. ...
... a focus on severe sepsis in oncology". Expert Review of Pharmacoeconomics & Outcomes Research. 6 (1): 49-58. doi:10.1586/ ...
Adverse outcomes associated with the use of drotrecogin alfa (activated) in patients with severe sepsis and baseline bleeding ... Clinical trials in severe sepsis with drotrecogin alfa (activated).. „Crit Care". 11 Suppl 5, s. S5, 2007. DOI: 10.1186/cc6156 ... Activated protein C for the treatment of severe sepsis.. „Clin Microbiol Infect". 15 (4), s. 319-24, Apr 2009. DOI: 10.1111/j. ... Efficacy and safety of recombinant human activated protein C for severe sepsis.. „N Engl J Med". 344 (10), s. 699-709, Mar 2001 ...
Bouza C, López-Cuadrado T, Saz-Parkinson Z, Blanco J (2014). "Epidemiology and recent trends of severe sepsis in Spain: a ... Ferreira FL, Bota DP, Bross A, Mélot C, Vincent JL (2001). "Serial evaluation of the SOFA score to predict outcome in ... Multiple organ failure can be associated with sepsis and is often fatal. Countries such as Spain, have shown a rise in ... However, there are tools physicians use when diagnosing multiple organ failure and when prognosing the outcome. The Sequential ...
2013). "Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2012" (PDF). ... EGDT, as compared to usual modern care, does not appear to improve outcomes but results in greater expense. In the event of ... Early goal-directed therapy is a more specific form of therapy used for the treatment of severe sepsis and septic shock. This ... November 2001). "Early goal-directed therapy in the treatment of severe sepsis and septic shock". The New England Journal of ...
Martin GS (June 2012). "Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes". Expert Rev Anti ... In rough order of increasing severity these are, bacteremia or fungemia; sepsis, severe sepsis or sepsis syndrome; septic shock ... then the condition is called severe sepsis. Once severe sepsis worsens to the point where blood pressure can no longer be ... Septic shock may be regarded as a stage of SIRS (Systemic Inflammatory Response Syndrome), in which sepsis, severe sepsis and ...
The algorithm of emergent resuscitation in the setting of severe sepsis and/or septic shock has been formally conceptualized by ... There was no significant difference in the primary outcome of mortality. However, the authors of these trials conclude that ... but Rivers's paper expanded the idea to incorporate all those initially presenting to the ED with signs of severe sepsis or ... "Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock". New England Journal of Medicine. 345 (19): ...
... leading to the lethal outcome of severe sepsis. Moreover, the team found that the toxic effect of free heme can be overcome by ... "A Central Role for Free Heme in the Pathogenesis of Severe Sepsis". Science Translational Medicine. 2 (51): 51ra71. doi:10.1126 ... Using experimental models of sepsis in mice, a research team led by Miguel Soares discovered an unsuspected mechanism that is ... "Metabolic Adaptation Establishes Disease Tolerance to Sepsis". Cell. 169 (7): 1263-1275.e14. doi:10.1016/j.cell.2017.05.031. ...
Disease severity partly determines the outcome.[7] The risk of death from sepsis is as high as 30%, while for severe sepsis it ... Severe sepsis is defined as sepsis with sepsis-induced organ dysfunction or tissue hypoperfusion (manifesting as hypotension, ... According to SIRS, there were different levels of sepsis: sepsis, severe sepsis, and septic shock.[16] The definition of SIRS ... Fungal sepsis accounts for approximately 5% of severe sepsis and septic shock cases; the most common cause of fungal sepsis is ...
Sepsis. Severe sepsis. Septic shock. Multiple organ dysfunction syndrome. Other shock. Cardiogenic shock. Distributive shock. ... have an effect on outcomes beyond implementing the individual elements alone. Each hospital's sepsis protocol may be customized ... Mortality associated with severe sepsis remains high at 30-50%. When shock is present, mortality is reported to be even higher ... Surviving Sepsis Campaign. The Surviving Sepsis Campaign (SSC) is a global initiative to bring together professional ...
Also, should be regarded in critical patients who may show a worse outcome when it is added to certain illnesses such as sepsis ... Rivers, E. (2001). "Early goal-directed therapy in the treatment of severe sepsis and septic shock". N. Engl. J. Med. 345 (19 ... demonstrated how to reduce mortality in patients with severe sepsis and septic shock through the optimization of different ... An incorrect practice can seriously affect the organ function and hence the outcome. Guiding fluid management using standard ...
For example, a child with sepsis or severe dehydration may seem unaffected and the acute condition is often identified only by ... Low blood pressure then is a pre-morbid sign and potentially too late for optimum outcomes. The goal was to create an easy-to- ... 6+: There are severe consequences if quick intervention is not established, including possible permanent damage or death. A ... 5: The child's status is deteriorating and a change in the plan of care is needed to improve outcomes. This is an urgent ...
... of the TLR2 have been identified and for some of them an association with faster progression and a more severe course of sepsis ... The authors showed a correlation of the polymorphism with a faster progression to the CD4+ < 200 cells/μL outcome for the ... "Polymorphisms of the toll-like receptor 2 and 4 genes are associated with faster progression and a more severe course of sepsis ... No association with occurrence of severe staphylococcal infection was found. Moreover, a recent study reported rs111200466, a ...
... sepsis, severe sepsis and septic shock: Incidence, morbidities and outcomes in surgical ICU patients". Intensive Care Medicine ... Systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis and their cascades Pittet, D; Rangel-Frausto, S; Li, N; ... sepsis, severe sepsis and their cascades Infections due to Candida spp Epidemiology of methicillin-resistant Staphylococcus ... "Impact of immunomodulating therapy on morbidity in patients with severe sepsis". American Journal of Respiratory and Critical ...
... is also associated with worse outcomes in people with sepsis. While most people with sepsis develop fevers ( ... People with moderate or severe hypothermia should be moved gently. In severe hypothermia, extracorporeal membrane oxygenation ( ... Extracorporeal rewarming is the fastest method for those with severe hypothermia. When severe hypothermia has led to cardiac ... In severe hypothermia, there may be paradoxical undressing, in which a person removes their clothing, as well as an increased ...
11,0 11,1 «Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes»։ Expert Review of Anti- ... Disease severity partly determines the outcome.[10] The risk of death from sepsis is as high as 30%, from severe sepsis as high ... Severe sepsis is defined as sepsis with sepsis-induced organ dysfunction or tissue hypoperfusion (manifesting as hypotension, ... According to SIRS, there were different levels of sepsis: sepsis, severe sepsis, and septic shock.[13] The definition of SIRS ...
"Time course of plasma gelsolin concentrations during severe sepsis in critically ill surgical patients". Critical Care. 12 (4 ... "Low Admission Plasma Gelsolin Concentrations Identify Community-acquired Pneumonia Patients at High Risk for Severe Outcomes". ... "Rhu-pGSN for Severe Covid-19 Pneumonia". ClinicalTrials.gov. U.S. National Library of Medicine. Retrieved 16 July 2020. CS1 ... The primary outcome will be the proportion of patients surviving on Day 14 without mechanical ventilation, vasopressors, or ...
One review found an increased risk of pneumonia and sepsis but not the overall risk of infection. Another review found a trend ... Xiao, G.; Guo, Q.; Shu, M.; Xie, X.; Deng, J.; Zhu, Y.; Wan, C. (2012). "Safety profile and outcome of mild therapeutic ... There is no difference in long term quality of life following mild compared to more severe cooling. In children, following ... Both 33 °C (91 °F) and 36 °C (97 °F) appear to result in similar outcomes. Targeted temperature management following traumatic ...
This can lead to severe complications, such as incomplete abortion, sepsis, hemorrhage, and damage to internal organs. Unsafe ... Although some studies show negative mental-health outcomes in women who choose abortions after the first trimester because of ... The degree of force, if severe, can cause serious internal injuries without necessarily succeeding in inducing miscarriage. In ... the mental-health outcome of a woman's second or greater abortion is less certain. Some older reviews concluded that abortion ...
Splenectomy is indicated for moderate to severe cases, but not mild cases. To decrease the risk of sepsis, post-splenectomy ... Research on outcomes is currently limited, but favorable. Surgical removal of the gallbladder may be necessary. Hereditary ... The clinical severity of HS varies from symptom-free carrier to severe hemolysis because the disorder exhibits incomplete ... Partial splenectomy: Since the spleen is important for protecting against encapsulated organisms, sepsis caused by encapsulated ...
Splenectomy is indicated for moderate to severe cases, but not mild cases. To decrease the risk of sepsis, post-splenectomy ... Research on outcomes is currently limited, but favorable. Surgical removal of the gallbladder may be necessary. Anemia Blood ... Partial splenectomy: Since the spleen is important for protecting against encapsulated organisms, sepsis caused by encapsulated ...
... and shock associated with severe blood loss. Open fractures can result in infection, osteomyelitis, and sepsis.[citation needed ... Since femoral shaft fractures are associated with violent trauma, there are many adverse outcomes, including fat embolism, ... The most common symptom is severe pain, which prevents movement of the leg. Femoral shaft fractures occur during extensive ...
November 2015). "VTE incidence and risk factors in patients with severe sepsis and septic shock". Chest. 148 (5): 1224-1230. ... Galanaud JP, Bosson JL, Quéré I (September 2011). "Risk factors and early outcomes of patients with symptomatic distal vs. ... When compared to this clot, clots that instead obstruct the common femoral vein cause more severe effects due to impacting a ... Infections, including sepsis, COVID-19, HIV, and active tuberculosis, increase risk. Chronic inflammatory diseases and some ...
Except during hypothermia and in severe sepsis, low mixed venous oxygen saturations are indication of inadequate hemodynamics. ... No study has definitively demonstrated improved outcome in critically ill patients managed with PA catheters.[1][2] Given that ... Its purpose is diagnostic; it is used to detect heart failure or sepsis, monitor therapy, and evaluate the effects of drugs. ... does not necessarily lead to improved outcome.[5] One explanation could be that nurses and physicians are insufficiently ...
When this happens, severe symptoms including blistering skin lesions and septic shock can sometimes lead to death.[9][10] This ... Infection with V. vulnificus leads to rapidly expanding cellulitis or sepsis.[5]:279 It was first isolated as a source of ... was associated with an improved outcome.[11] Prospective clinical trials are needed to confirm this finding, but in vitro data ... Invasive sepsis can occur after eating raw or undercooked shellfish, especially oysters. V. vulnificus is 80 times more likely ...
The combination of severe vomiting and diarrhoea often leads to severe dehydration.[29] Next, shortness of breath and chest ... are associated with improved outcomes.[10] Supportive efforts also improve outcomes.[1] This includes either oral rehydration ... sepsis, borreliosis, EHEC enteritis, leptospirosis, scrub typhus, plague, Q fever, candidiasis, histoplasmosis, trypanosomiasis ... West TE, von Saint André-von Arnim A (November 2014). "Clinical presentation and management of severe Ebola virus disease". ...
"Oregon Study: Medicaid 'Had No Significant Effect' On Health Outcomes vs. Being Uninsured". Forbes. Retrieved April 18, 2019.. ... sepsis; congestive heart failure; chronic obstructive pulmonary disease; and complications of devices, implants and grafts.[78] ... and reduced severe food insecurity.[96] ... In terms of self-reported health outcomes, having insurance was ... and some health outcomes, as well as economic benefits to states and health providers.[2][8] ...
For this same group, severe cardiovascular events were observed with a rate of about 1 in 1500. The most common severe adverse ... This puts a patient at high risk of infections, sepsis and septic shock, despite prophylactic antibiotics. However, antiviral ... 2005). "Comparative outcome of nonmyeloablative and myeloablative allogeneic hematopoietic cell transplantation for patients ... Severe reactions[edit]. A study that surveyed 2408 donors found that serious adverse events (requiring prolonged ...
An R, Tang Y, Chen L, Cai H, et al «Encephalitis is mediated by ROP18 of Toxoplasma gondii, a severe pathogen in AIDS patients ... Marco I, Velarde R, López-Olvera JR, Cabezón O, et al «Systemic Toxoplasmosis and Gram-Negative Sepsis in a Southern Chamois ( ... Aleixo AL, Curi AL, Benchimol EI, Amendoeira MR «Toxoplasmic Retinochoroiditis: Clinical Characteristics and Visual Outcome in ...
Severe radiologic signs (pneumoperitoneum). *Additional laboratory changes (metabolic and respiratory acidosis, disseminated ... correlating findings with outcomes. Pediatr Radiol. 2013 Jun 15. ... Sepsis, anal fissure, infectious enterocolitis, Hirschsprung ... A Cochrane review in 2014 found that supplementation of probiotics enterally "prevents severe NEC as well as all-cause ...
If bacteria do not remain in one area but spread through the bloodstream, the infection is called sepsis and can be rapid and ... Blood transfusions may also be used to treat a severe anaemia or thrombocytopenia caused by a blood disease. People with ... In cases in which a choice between intravenous therapy and oral treatment may be made to achieve the same outcome, such as in ... An infected central IV poses a higher risk of sepsis, as it can deliver bacteria directly into the central circulation. ...
In one study of 143 pediatric outcomes, a failure rate of 1.4% was reported in the loop group versus 10.5% in the packing group ... Antibiotics in addition to standard incision and drainage is recommended in persons with severe abscesses, many sites of ...
... though these symptoms are usually not as severe or long-lasting as influenza. The most dangerous adverse effect is a severe ... Sometimes, influenza may have abnormal presentations, like confusion in the elderly and a sepsis-like syndrome in the young.[34 ... Angelo SJ, Marshall PS, Chrissoheris MP, Chaves AM (April 2004). "Clinical characteristics associated with poor outcome in ... Influenza, commonly known as the flu, is an infectious disease caused by an influenza virus.[1] Symptoms can be mild to severe. ...
Outcomes are typically good when treated. Most can expect to live relatively normal lives. Someone with the disease should be ... An "Addisonian crisis" or "adrenal crisis" is a constellation of symptoms that indicates severe adrenal insufficiency. This may ... sepsis, and bleeding into both adrenal glands.[1][4] Secondary adrenal insufficiency is caused by not enough ... Long-term outcomes with treatment are typically good.[6] It is named after Thomas Addison, a graduate of the University of ...
Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes.. Expert review of anti-infective therapy ... Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2012 (PDF). Critical Care ... 败血症(拉丁語:Sepsis)指的是由於感染所引起的全身性發炎的嚴重疾病[1]。常見的臨床症狀包括發燒、呼吸頻率和心跳加速,以及意識不清[2]。有時患者也會發生特定的臨床症狀,如因肺炎引起的咳
... risk factors and outcomes of new-onset atrial fibrillation in patients with sepsis: a systematic review". Critical Care ( ... During AF, if all of the impulses from the atria passed through the AV node, there would be severe ventricular tachycardia, ... Sepsis also increases the risk of developing new-onset atrial fibrillation.[26][27] Disorders of breathing during sleep, such ... Both methods have similar outcomes.[104] Rate control lowers the heart rate closer to normal, usually 60 to 100 bpm, without ...
While bleeding is predominantly in the severe and fatal cases, sometimes it may occur in mild cases and not affect outcomes.[34 ... and fulminating sepsis.[59] ... A man with severe hemorrhagic-type smallpox. (Bangladesh, 1975) ... Malignant smallpox was accompanied by a severe prodromal phase that lasted 3-4 days, prolonged high fever, and severe symptoms ... Because the person was infected with Variola virus, a severe infection could result, and the person could transmit smallpox to ...
Several cases of severe hypokalemia have been reported.[14][15] Meropenem, like other carbapenems, is a potent inducer of ... sepsis, and anthrax.[1] It is given by injection into a vein.[1] ... "Clinical outcomes of prolonged infusion (extended infusion or ... "Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and ... continuous infusion) versus intermittent bolus of meropenem in severe infection: A meta-analysis". PLoS ONE. 13 (7): e0201667. ...
In very severe myelosuppression, which occurs in some regimens, almost all the bone marrow stem cells (cells that produce white ... The FOLFOX study also demonstrated an improvement in treatment outcomes.[22] Positive response increased from 46% in the BSA- ... such as sepsis, or as localized outbreaks, such as Herpes simplex, shingles, or other members of the Herpesviridea.[66] The ... Sometimes hair has a tendency to curl after regrowth, resulting in "chemo curls." Severe hair loss occurs most often with drugs ...
The variables involved in the outcome of a host becoming inoculated by a pathogen and the ultimate outcome include: *the route ... Severe infections of the brain are usually treated with intravenous antibiotics. Sometimes, multiple antibiotics are used in ... and staphylococcus releases toxins that produce shock and sepsis. Not all infectious agents cause disease in all hosts. For ... For example, more than half of cases of encephalitis, a severe illness affecting the brain, remain undiagnosed, despite ...
"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012". Intensive Care ... 2012). "Ranitidine Is Associated With Infections, Necrotizing Enterocolitis, and Fatal Outcome in Newborns". Pediatrics. 129 (1 ... When omeprazole and ranitidine were compared in a study of 144 people with severe inflammation and erosions or ulcers of the ... such as sepsis, pneumonia, urinary tract infection) was reported in patients receiving ranitidine in a cohort analysis of 274 ...
High circulating CD39(+) regulatory T cells predict poor survival for sepsis patients. „Int J Infect Dis". 30, s. 57-63, ... CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis. „Arthritis Rheum". 48 (5), s. 1452-1460 ... Regulatory CD4+CD25+ T cells in the peripheral blood of lung transplant recipients: correlation with transplant outcome. „ ... Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis. „Crit Care Med". 31 (7), ...
It is indicated for carpal and fetlock joint dysfunctions, but not when joint sepsis or fracture are suspected. It is ... In the late 1970s, intraocular lens implantation was often followed by severe corneal edema, due to endothelial cell damage ... It may cause mild heating of the joint if directly injected, but this does not affect the clinical outcome. Intra-articularly ... and this response is associated with tumor growth and an unfavorable outcome". Am. J. Pathol. 179 (4): 1961-1968. doi:10.1016/j ...
Sepsis. Severe sepsis. Septic shock. Multiple organ dysfunction syndrome. Other shock. Cardiogenic shock. Distributive shock. ... APACHE II score can be used to describe the morbidity of a patient when comparing the outcome with other patients. ... higher scores correspond to more severe disease and a higher risk of death. The first APACHE model was presented by Knaus et al ... history of severe organ insufficiency, immunocompromised state) and baseline demographics such as age. The calculation method ...
The myopathic is the least severe form of the deficiency and can manifest at any point in the lifespan of the patient. The ... Common symptoms include liver failure, sepsis, failure to grow, and mental impairment, among others. Buildup of a second toxic ... "Literature review and outcome of classic galactosemia diagnosed in the neonatal period". Clinical Laboratory. 59 (9-10): 1139- ... Common symptoms of the lethal neonatal form and the severe infantile forms are liver failure, heart problems, seizures and ...
Blood transfusions may also be used to treat a severe anaemia or thrombocytopenia caused by a blood disease. People with ... In cases in which a choice between intravenous therapy and oral treatment may be made to achieve the same outcome, such as in ... cellulitis and sepsis. The US Centers for Disease Control and Prevention updated their guidelines and now advise the cannula ... Children in emergency departments being treated for dehydration in particular have better outcomes with oral treatment because ...
Sepsis. Severe sepsis. Septic shock. Multiple organ dysfunction syndrome. Other shock. Cardiogenic shock. Distributive shock. ... Definitions, mechanisms, relevant outcomes, and clinical trial coordination". Am J Respir Crit Care Med. 149 (3 Pt 1): 818-24. ... Worldwide, severe sepsis is the most common trigger causing ARDS.[28] Other triggers include mechanical ventilation, sepsis, ... sepsis), following trauma, multiple blood transfusions (TRALI), severe burns, severe inflammation of the pancreas (pancreatitis ...
This delivery system can cause sepsis and thrombosis. Prostacyclin is unstable, and therefore has to be kept on ice during ... Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR). References[edit]. .mw-parser-output .reflist{font-size:90%;margin- ... Indeed, this condition frequently accompanies severe heart or lung conditions.[11] A 1973 World Health Organization meeting was ... An increased risk of sepsis with intravenous Remodulin has been reported by the CDC. Iloprost is also used in Europe ...
Rhesus c hemolytic disease of the newborn can range from a mild to severe disease - is the third most common form of severe HDN ... "Alloimmunization due to red cell antibodies in Rhesus positive Omani Pregnant Women: Maternal and Perinatal outcome". Asian ... In some cases, the direct Coombs will be negative but severe, even fatal HDN can occur.[4] An indirect Coombs needs to be run ... HDN can be the cause of hydrops fetalis, an often-severe form of prenatal heart failure that causes fetal edema.[2] ...
... being exposed to severe trauma within the pregnancy period, rapid acceleration and deceleration and uterine compression ...
The maximum heart rate (HRmax) is the highest heart rate an individual can achieve without severe problems through exercise ... "Resting heart rate: a modifiable prognostic indicator of cardiovascular risk and outcomes?". The Canadian Journal of ... Severe hyponatremia leads to both bradycardia and other arrhythmias. Hypokalemia (low potassium levels) also leads to ... Severe changes in pH will lead to denaturation of the enzyme.[11] ...
For this same group, severe cardiovascular events were observed with a rate of about 1 in 1500. The most common severe adverse ... This puts a patient at high risk of infections, sepsis and septic shock, despite prophylactic antibiotics. However, antiviral ... 2005). "Comparative outcome of nonmyeloablative and myeloablative allogeneic hematopoietic cell transplantation for patients ... Severe liver injury can result from hepatic veno-occlusive disease (VOD). Elevated levels of bilirubin, hepatomegaly and fluid ...
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.. Angus DC1, ... To determine the incidence, cost, and outcome of severe sepsis in the United States. ... Severe sepsis is a common, expensive, and frequently fatal condition, with as many deaths annually as those from acute ... We defined severe sepsis as documented infection and acute organ dysfunction using criteria based on the International ...
Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital ... Population-based rates of severe sepsis by age and race in six U.S. states, 2001. Black rates are depicted as diamonds, non- ... Adjusted rate ratios of severe sepsis in six U.S. states, 2001. Rate ratios reflect age, race, sex, ZIP code-level poverty, and ... To explore racial differences in the incidence and associated case fatality of severe sepsis, accounting for clinical, social, ...
Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock. This study has ... Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock. ... Severe Sepsis Septic Shock Procedure: intensive insulin therapy Phase 2 Phase 3 ... Sepsis shock:. *Sepsis associated to hypotension despite adequate fluid resuscitation, with hypoperfusion including lactic ...
Causes and Factors Associated With Outcomes in Community-acquired Sepsis and Severe Sepsis in Northeast Thailand. The safety ... Secondary Outcome Measures : *Percentage of deaths caused by community-acquired sepsis and severe sepsis in Northeast Thailand ... and mortality in community-acquired sepsis and severe sepsis in NE Thailand, including causes of sepsis, sepsis resuscitation, ... Causes and Factors Associated With Outcomes in Community-acquired Sepsis and Severe Sepsis in Northeast (NE) Thailand. ...
The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic ... and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest. 2017 Jun;151(6): ... Sepsis and scientific revolutions. Crit Care Med. 2013 Dec;41(12):2770-2. doi: 10.1097/CCM.0b013e31829eb98f. ...
Prediction of Outcome from Community-Acquired Severe Sepsis and Septic Shock in Tertiary-Care University Hospital in a ... were with severe sepsis and 49 (26.6%) had septic shock. Overall, ninety-five (51.6%) patients have died, 60 (44.4%) in severe ... Our aim was to determine the risk factors on mortality in adult patients with community-acquired severe sepsis and septic shock ... and three or more organ dysfunctions are important independent risk factors for mortality in patients with severe sepsis and ...
... ... 3-hour treatment recommendations and patient-centered outcomes between patients with severe sepsis who received a sepsis- ... Severe sepsis continues to be an underdiagnosed and undertreated condition. Patients who were diagnosed had higher treatment ... 3-hour treatment recommendations along with patient-centered outcomes in patients who were diagnosed with severe sepsis and ...
... ... a finding suggestive of monocyte dysfunction in sepsis, as well as worse clinical outcomes. ... Immune dysfunction may be a potential link between failure to mount a fever and poor outcomes. The purpose of this study was to ... Forty-four patients (47.8%) developed a fever within 24 h of sepsis diagnosis. There were no significant differences in HLA-DR ...
... and ACE inhibitor use on clinical outcomes for elderly subjects hospitalized with severe sepsis. Eric Mortensen, Mary Jo Pugh, ... and ACE inhibitor use on clinical outcomes for elderly subjects hospitalized with severe sepsis ... and ACE inhibitor use on clinical outcomes for elderly subjects hospitalized with severe sepsis ... and ACE inhibitor use on clinical outcomes for elderly subjects hospitalized with severe sepsis ...
Does early appropriate antibiotic therapy improve the outcome of severe sepsis or septic shock?. *N Saito1. , ... Dellinger RP, Levy MM, Carlet JM, et al.: Surviving sepsis campaign: International guidelines for management of severe sepsis ... EAAT did not affect the outcome. The prognostic factors for severe sepsis and septic shock identified in this study were age, ... Saito, N., Sakamoto, Y. & Mashiko, K. Does early appropriate antibiotic therapy improve the outcome of severe sepsis or septic ...
The aim of the present study was to identify prognostic factors in 54 consecutive cases with abdominal sepsis admitted to the ... This was a retrospective record review of cases with abdominal sepsis admitted to the ICU. Of 54 patients that were studied, ... We conclude that patients with abdominal sepsis have an extremely high mortality and utilise an enormous amount of limited ... total parenteral nutrition and blood transfusions were predictive of adverse outcomes in these patients. ...
We examined the utility of the SOFA score for assessing outcome of patients with severe sepsis with evidence of hypoperfusion ... The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of ... The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of ... The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of ...
A matched cohort study was conducted to analyze the relationship between IFI and outcomes of severe sepsis. A total of 318 ... on severe sepsis is not well understood. The aim of this study was to investigate the impact that IFI has on the outcomes of ... Patients who met criteria for severe sepsis were included. IFI was identified using established criteria based on microbiologic ... Independent risk factors for IFI in patients with severe sepsis included mechanical ventilation (>3 days), Acute Physiology and ...
Severe sepsis in two Ugandan hospitals: A prospective observational study of management and outcomes in a predominantly HIV-1 ... Severe sepsis in two Ugandan hospitals: A prospective observational study of management and outcomes in a predominantly HIV-1 ... Severe sepsis in two Ugandan hospitals : A prospective observational study of management and outcomes in a predominantly HIV-1 ... Severe sepsis in two Ugandan hospitals : A prospective observational study of management and outcomes in a predominantly HIV-1 ...
... diagnosis and early management of sepsis for all populations ... Outcome. Levels of awareness of symptoms in people with ... Sepsis cannot always be ruled out for people who have been assessed as being at low risk of severe illness or death from sepsis ... Low risk of severe illness or death from sepsis. People with suspected sepsis who do not currently meet any high or moderate to ... Suspected sepsis. Suspected sepsis is used to indicate people who might have sepsis and require face-to-face assessment to ...
Management and outcomes of severe dengue patients presenting with sepsis in a tropical country ... Management and outcomes of severe dengue patients presenting with sepsis in a tropical country ... Management and outcomes of severe dengue patients presenting with sepsis in a tropical country ...
Population-based epidemiological surveillance of sepsis is limited to basic data available in administrative ... Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med ... Defining sepsis and severe sepsis. Sepsis was defined using an existing administrative data definition developed by CIHI3,4 and ... Length of stay and hospital outcomes among sepsis and non-sepsis patients. Patients hospitalized with sepsis were more often ...
Drotrecogin alfa (activated protein C [APC]) vs placebo for severe sepsis†. Outcome at 28 d. APC. Placebo. RRR (95% CI). NNT ( ... In patients with severe sepsis (known or suspected infection) plus ≥ 3 signs of systemic inflammation and sepsis-induced ... 1728 patients with severe sepsis were allocated, and 1690 (mean age 61 y, 57% men, 82% white) received study drugs and were ... Recombinant human activated protein C reduced all-cause mortality in patients with severe sepsis PDF. ACP J Club. 2001 Nov-Dec; ...
Sixty-seven consecutive patients with severe sepsis and 33 controls were evaluated. Plasma DNA levels were estimated by real- ... This study aimed to determine the prognostic value of circulating plasma DNA levels in severe septic patients presenting at the ... The median plasma nuclear and mitochondria DNA levels for severe septic patients on admission were significantly higher than ... Plasma DNA has potential use for predicting outcome in septic patients arriving at the emergency room. Plasma mitochondrial DNA ...
25 had severe sepsis or septic shock and 12 died. Severe sepsis may be a rare complication of chikungunya virus infection. ... Of these, 110 were nonpregnant adults; 42 had severe disease, and of those, ... Outcome. Death. 12 (48). 2 (3). ,0.001. *Values are no. (%) except as indicated. All patients were hospitalized and had ... Severe sepsis or septic shock, n = 25. No severe sepsis or septic shock, n = 85. p value†. ...
Antimicrobial Delay and Outcome in Severe Sepsis. Kumar, Anand Kumar, Anand Less ... Translated Sepsis Guideline To access translated versions of this guideline, please visit the Surviving Sepsis Campaign website ... Safety, Feasibility, and Outcomes of Induced Hypothermia Therapy Following In-Hospital Cardiac Arrest-Evaluation of a Large ... Choice of Crystalloid and Mortality in Sepsis-All in the Timing?. Jones, Brian L.; Smith, Stephen M. ...
Antimicrobial Delay and Outcome in Severe Sepsis. Kumar, Anand Kumar, Anand Less ... The dobutamine oxygen flux test: A road map to outcome in sepsis?. Kumar, Anand ... Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2016. Rhodes, Andrew; Evans, ... Antibiotics in sepsis and septic shock: Like everything else in life, timing is everything*. Zubert, Shelly; Funk, Duane J.; ...
... severe sepsis or septic shock admitted to Dhaka Hospital from 10/25/2009-10/25/2011. The primary outcome was inpatient ... 328 patients with a primary diagnosis of sepsis, severe sepsis, or septic shock were included (143 pre- and185 post-protocol) ... We hypothesized that implementation of a pediatric sepsis protocol improved clinical outcomes, including reducing mortality and ... Sepsis protocols have been shown to be a cost-effective strategy to improve morbidity and mortality in a variety of populations ...
The quicker the treatment, the better the outcome. Shah and a multi-disciplinary team at Le Bonheur Childrens Hospital have ... "The goal was to develop a tool that could recognize severe sepsis rather than some of the mimics of severe sepsis," said Shah. ... Along that slippery slope, its hard to identify markers that a patient is progressing from sepsis to severe sepsis to septic ... "Severe sepsis is the last step before the slippery slope down to septic shock, which has a very high incidence of mortality and ...
A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsis.. Villar J1, Pérez-Méndez L, Flores C, ... previously associated with susceptibility to severe sepsis, contributes to morbidity and mortality in severe sepsis. ... A total of 183 critically ill patients fulfilling the International Sepsis Criteria for severe sepsis. ... 665 in the CXCL2 gene may be an independent predictor of mortality for severe sepsis. Additional studies are needed to confirm ...
... and stroke have been translated into improved outcomes by earlier diagnosis and application of therapy at the most proximal ... a coordinated approach to sepsis management is necessary to duplicate the progress in outcomes seen in patients with conditions ... Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings ... Most therapies for these diseases are instituted prior to admission to an ICU; this approach to the sepsis patient has been ...
The effect of homocysteine on the clinical outcomes of ventilated patients with severe sepsis.. Tsantes A1, Tsangaris I, ... patients with severe sepsis/septic shock and to assess the association of these levels with relevant clinical outcomes. ... The primary outcomes were mortality at 28 and 90 days; secondary outcomes included the number of days without renal or ... The study cohort included 102 mechanically ventilated patients with severe sepsis or septic shock. Demographics, comorbidities ...
Primary Outcome Measures : *Effect of clarithromycin in mortality and risk for death by severe sepsis/shock and multiple organ ... Sepsis Severe Sepsis Septic Shock Drug: Clarithromycin Drug: Dextrose 5% Phase 3 ... The study enrolled 200 subjects with ventilator-associated pneumonia (VAP) and sepsis, severe sepsis or septic shock; 100 ... treated patients separately for patients with sepsis; for patients with severe sepsis; and for patients with septic shock. Odds ...
Objective: To provide further evidence for the efficacy and safety of drotrecogin alfa (activated) treatment in severe sepsis. ... Design: Single-arm, open-label, trial of drotrecogin alfa (activated) treatment in severe sepsis patients. Enrollment began in ... Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival ... 0.2%). ENHANCE patients treated within 0-24 hrs from their first sepsis-induced organ dysfunction had lower observed mortality ...
This is a retrospective analysis of immunocompetent adult patients with severe sepsis and septic shock at a tertiary medical ... In patients with severe sepsis or septic shock, current smoking was associated with a longer hospital stay, the need for ... The primary outcome was the effect of active smoking on hospital mortality. Chi-square test and logistic regression were used ... Wilcoxon rank-sum was utilized to test the differences in continuous outcomes among the varied smoking histories. Multivariable ...
  • All patients (n = 192,980) meeting criteria for severe sepsis based on the International Classification of Diseases, Ninth Revision, Clinical Modification. (nih.gov)
  • Among patients with severe sepsis admitted to the ICU, adjustments for clinical characteristics and the treating hospital fully explained blacks' higher ICU case fatality. (nih.gov)
  • The purpose of this study is to determine the effect of the intensive insulin therapy on coagulation and fibrinolysis in patients affected by severe sepsis and septic shock. (clinicaltrials.gov)
  • Our aim was to determine the risk factors on mortality in adult patients with community-acquired severe sepsis and septic shock. (hindawi.com)
  • This prospective single centre study was conducted from January 1, 2008 to December 31, 2010, and included 184 patients, of whom 135 (73.4%) were with severe sepsis and 49 (26.6%) had septic shock. (hindawi.com)
  • Overall, ninety-five (51.6%) patients have died, 60 (44.4%) in severe sepsis and 35 (71.4%) patients with septic shock. (hindawi.com)
  • In addition to SAPS II, positive blood culture, and three or more organ dysfunctions are important independent risk factors for mortality in patients with severe sepsis and septic shock. (hindawi.com)
  • Potential study participants will be adult patients who are presented at the hospital with community-acquired sepsis. (clinicaltrials.gov)
  • The aim of this study was to compare completion of the Surviving Sepsis Campaign 3-hour treatment recommendations and patient-centered outcomes between patients with severe sepsis who received a sepsis-specific diagnosis code with those who did not. (ovid.com)
  • This was a retrospective cohort analysis of adult patients admitted through an academic medical center ED who received an antibiotic and met criteria for severe sepsis. (ovid.com)
  • We measured and compared the Surviving Sepsis Campaign 3-hour treatment recommendations along with patient-centered outcomes in patients who were diagnosed with severe sepsis and those who were not. (ovid.com)
  • Patients with a diagnosis code had higher mortality (6.3% vs 2.3%), more frequent ICU admissions (44.7% vs 22.5%), and longer hospitalizations (9.2 ± 6.9 days vs 6.9 ± 6.7 days) than did patients with severe sepsis with no diagnosis code (all P (ovid.com)
  • Patients who were diagnosed had higher treatment rates yet experienced worse outcomes. (ovid.com)
  • Continued investigation is needed to identify factors contributing to diagnosis, treatment, and outcomes in patients with severe sepsis. (ovid.com)
  • Forty-four patients (47.8%) developed a fever within 24 h of sepsis diagnosis. (ovid.com)
  • Additional research is needed to assess if these medications may be protective for patients hospitalized with sepsis. (ersjournals.com)
  • We conclude that patients with abdominal sepsis have an extremely high mortality and utilise an enormous amount of limited intensive care resources. (journals.co.za)
  • The length of ICU stay, APACHE II score on admission, number of relook laparotomies, whether the abdomen was left open or not, and requirement for inotropic support, dialysis, total parenteral nutrition and blood transfusions were predictive of adverse outcomes in these patients. (journals.co.za)
  • We examined the utility of the SOFA score for assessing outcome of patients with severe sepsis with evidence of hypoperfusion at the time of emergency department (ED) presentation. (iupui.edu)
  • Patients ED patients with severe sepsis with evidence of hypoperfusion. (iupui.edu)
  • Conclusions The SOFA score provides potentially valuable prognostic information on in-hospital survival when applied to patients with severe sepsis with evidence of hypoperfusion at the time of ED presentation. (iupui.edu)
  • Patients who met criteria for severe sepsis were included. (biomedcentral.com)
  • A total of 318 patients with severe sepsis were enrolled during the study period, of whom 90 (28.3%) were identified as having IFI. (biomedcentral.com)
  • IFI is frequent in patients with severe sepsis in surgical ICUs and is associated with excess risk for hospital mortality, longer ICU and hospital stays, and greater consumption of medical resources. (biomedcentral.com)
  • Invasive fungal infection (IFI) is a severe clinical complication in immunocompromised patients, such as neutropenic patients, recipients of bone marrow or solid organ transplants, cancer patients receiving chemotherapy, and HIV-infected patients. (biomedcentral.com)
  • According to epidemiologic studies [ 4 - 13 ], severe sepsis has become a leading cause of morbidity and mortality in critical illness, and etiologic evidence [ 14 ] indicates that the incidence of fungal infection in septic patients is increasing. (biomedcentral.com)
  • Fungal organisms are common pathogens in surgical patients and patients suffering from severe sepsis. (biomedcentral.com)
  • Recently, the large pan-European Sepsis Occurrence in Acutely Ill Patients (SOAP) study [ 4 ] reported that fungal infection was observed in 17% of all septic patients in European ICUs. (biomedcentral.com)
  • In the present study we attempted to determine the impact that IFI has on outcomes of severe septic patients in multiple surgical ICUs in China. (biomedcentral.com)
  • We undertook a matched cohort study in which severe septic patients with and without IFI were matched for unit, age, sex and severity of illness. (biomedcentral.com)
  • We conducted a prospective observational study reporting the management and outcomes of severely septic patients in two Ugandan hospitals. (elsevier.com)
  • Methodology/Results: Three-hundred eighty-two patients fulfilled enrollment criteria for a severe sepsis syndrome. (elsevier.com)
  • Conclusion: Patients presenting with sepsis syndromes to two Ugandan hospitals had late stage HIV infection and high mortality. (elsevier.com)
  • We sought to determine if routinely collected Census data, linked to hospitalization data, can provide a broad socio-demographic profile of patients admitted to Canadian hospitals with sepsis. (springer.com)
  • Patients admitted to hospital with sepsis were identified using the Canadian Institute for Health Information administrative data definition. (springer.com)
  • Of those individuals successfully linked to the 2006 long-form Canadian Census, 10,400 patients of 18 yr and older were admitted to hospital with sepsis between the fiscal years 2006/2007 and 2008/2009. (springer.com)
  • Nous avons cherché à déterminer si, en liant les données du Recensement aux données d'hospitalisation, cet ensemble pouvait nous procurer un large profil sociodémographique des patients admis pour traiter un état septique dans les hôpitaux canadiens. (springer.com)
  • En liant le Recensement canadien de 2006 (le plus récent disponible aux fins de liaison) aux Données de la Base de données sur les congés des patients de 2006/2007 à 2008/2009, nous avons créé une cohorte fondée sur une population d'environ 3 433 900 Canadiens. (springer.com)
  • Les patients admis à l'hôpital suite à un sepsis ont été identifiés à l'aide de la définition de l'Institut canadien d'information sur la santé sur les données administratives. (springer.com)
  • Parmi les individus qui ont pu être liés au Recensement canadien de 2006, 10 400 patients de 18 ans ou plus ont été admis à l'hôpital en raison d'un sepsis entre les années financières 2006/2007 et 2008/2009. (springer.com)
  • The sensitivity and specificity of biomarkers and scoring systems used for predicting fatality of severe sepsis patients remain unsatisfactory. (biomedcentral.com)
  • This study aimed to determine the prognostic value of circulating plasma DNA levels in severe septic patients presenting at the Emergency Department (ED). (biomedcentral.com)
  • Sixty-seven consecutive patients with severe sepsis and 33 controls were evaluated. (biomedcentral.com)
  • The median plasma nuclear and mitochondria DNA levels for severe septic patients on admission were significantly higher than those of the controls. (biomedcentral.com)
  • Plasma DNA has potential use for predicting outcome in septic patients arriving at the emergency room. (biomedcentral.com)
  • Apoptosis plays an important role in the patho-physiologic process of sepsis and circulating DNA has been detected in the plasma of septic patients [ 12 ]. (biomedcentral.com)
  • The aim of the present study was to investigate the prognostic value of circulating plasma DNA levels in patients with severe sepsis in the ED and intensive care setting. (biomedcentral.com)
  • This prospective study on the time course of plasma nuclear and mitochondrial DNA levels in severe sepsis and septic shock patients was conducted over a one-year period (January to December 2011). (biomedcentral.com)
  • Randomized (allocation concealed*), blinded (patients, clinicians, outcome assessors, and sponsors),* placebo-controlled trial with 28-day follow-up and planned interim analyses. (acpjc.org)
  • 1728 patients with severe sepsis were allocated, and 1690 (mean age 61 y, 57% men, 82% white) received study drugs and were analyzed. (acpjc.org)
  • Drotrecogin alfa (recombinant human activated protein C) reduced all-cause mortality in patients with severe sepsis without increasing the rate of adverse effects. (acpjc.org)
  • The international multicenter randomized controlled trial of APC by Bernard and colleagues unequivocally showed a favorable mortality benefit among patients with severe sepsis. (acpjc.org)
  • Given the evolving definitions of sepsis, sepsis syndrome, and septic shock over the past decade, clinicians should familiarize themselves with the inclusion criteria used in this trial to encourage the timely administration of this drug to appropriate patients. (acpjc.org)
  • Activated protein C is relatively cost effective when targeted to patients with severe sepsis, greater severity of illness (an APACHE II score of 25 or more), and a reasonable life expectancy if they survive the episode of sepsis ( 1 ). (acpjc.org)
  • p value denotes the comparisons between the 25 patients with severe sepsis or septic shock and the 85 patients with no severe sepsis or septic shock, based on nonparametrical tests. (cdc.gov)
  • A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsis. (cdc.gov)
  • A total of 183 critically ill patients fulfilling the International Sepsis Criteria for severe sepsis. (cdc.gov)
  • The tool is now used regularly with adolescent patients, and overall severe sepsis mortality for Le Bonheur is at an all-time low. (lebonheur.org)
  • They may not be able to identify these patients with severe sepsis earlier. (lebonheur.org)
  • The effect of homocysteine on the clinical outcomes of ventilated patients with severe sepsis. (cdc.gov)
  • Our primary aim was to measure plasma homocysteine levels in mechanically ventilated patients with severe sepsis/septic shock and to assess the association of these levels with relevant clinical outcomes. (cdc.gov)
  • The study cohort included 102 mechanically ventilated patients with severe sepsis or septic shock. (cdc.gov)
  • Our data suggest that plasma homocysteine levels may not inform the prognosis of mechanically ventilated patients with severe sepsis/septic shock. (cdc.gov)
  • In response, a trial comparing early goal-directed therapy (EGDT) vs standard care was performed using specific criteria for the early identification of high-risk sepsis patients, verified definitions, and a consensus-derived protocol to reverse the hemodynamic perturbations of hypovolemia, vasoregulation, myocardial suppression, and increased metabolic demands. (nih.gov)
  • Although EGDT is faced with challenges, a coordinated approach to sepsis management is necessary to duplicate the progress in outcomes seen in patients with conditions such as acute myocardial infarction, stroke, and trauma. (nih.gov)
  • The herein protocol is based on the results of one former clinical trial conducted by our study group showing the considerable efficacy of intravenously administered clarithromycin as an adjuvant to antimicrobial chemotherapy for patients with sepsis, septic shock and respiratory failure in the field of ventilator-associated pneumonia. (clinicaltrials.gov)
  • The proposed clinical trial is based on the need to generalize the application of intravenous clarithromycin in the total of admitted septic patients irrespective of the underlying cause of sepsis. (clinicaltrials.gov)
  • The proposed clinical trial is based on the extremely beneficial results of clarithromycin in the septic population of patients with VAP creating the following needs: a) to generalize the application of intravenous clarithromycin in the total of admitted septic patients irrespective of the underlying cause of sepsis, and b) to expand the effect of clarithromycin over a greater time period than the first 19 days post start of administration. (clinicaltrials.gov)
  • Our goal was to examine whether EGDT improved outcome when employed in the resuscitation of adult sepsis patients compared with control care by meta-analysis. (springeropen.com)
  • Studies were eligible if they compared the effects of EGDT versus control care on mortality in adult patients with severe sepsis and septic shock. (springeropen.com)
  • Data including mortality, sample size of the patients with severe sepsis and septic shock, and resuscitation endpoints were extracted. (springeropen.com)
  • Eight studies compared EGDT with control care, and 3959 severe sepsis and septic shock patients were included. (springeropen.com)
  • Clinical data were collected from hospital charts of patients with severe sepsis and septic shock admitted to a mixed intensive care unit from November 2003 to February 2004. (bvsalud.org)
  • Garnacho-Montero J, Garcia-Garmendia JL, Barrero-Almodovar A, Jimenez-Jimenez FJ, Perez-Paredes C, Ortiz-Leyba C. Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis. (jamanetwork.com)
  • We analyzed data from a sepsis registry that included adult patients who initially presented to the emergency department (ED) and met criteria for severe sepsis or septic shock. (ceemjournal.org)
  • Antibiotic administration within three hours from the time of ED arrival was significantly associated with improved outcomes, including in-hospital survival, reversal of organ failure, and shorter hospital LOS, in patients with severe sepsis and septic shock. (ceemjournal.org)
  • Timely antibiotic administration is a particularly crucial element for survival in patients with severe sepsis and septic shock. (ceemjournal.org)
  • Proper treatment of the infection source is vital for effective and prompt treatment of patients with severe sepsis and septic shock. (ceemjournal.org)
  • In patients with septic shock, a delay in antibiotic administration from the time when hypotension first appears is significantly associated with increased mortality rates, and similar results have been reported in patients with severe sepsis [ 7 - 9 ]. (ceemjournal.org)
  • Based on existing observational studies, the 2012 Surviving Sepsis Campaign (SSC) guidelines recommend antibiotic administration within one hour of diagnosis of sepsis or prompt antibiotic administration within 3 hours for patients in the emergency department (ED) [ 10 ]. (ceemjournal.org)
  • This study explored the differences in prognosis based on early administration of antibiotics as recommended by the SSC guidelines in ED patients with severe sepsis and septic shock. (ceemjournal.org)
  • Long-term outcomes in patients with severe sepsis randomised to resuscitation with hydroxyethyl starch 130/0.42 or Ringer's acetate. (lsh.is)
  • We assessed long-term mortality and hospitalisation in patients with severe sepsis resuscitated with hydroxyethyl starch (HES) or Ringer's acetate. (lsh.is)
  • This was an investigator-initiated, parallel-grouped, blinded randomised trial using computer-generated allocation sequence and centralised allocation data that included 804 patients with severe sepsis needing fluid resuscitation in 26 general intensive care units (ICUs) in Scandinavia. (lsh.is)
  • The long-term mortality rates did not differ in patients with severe sepsis assigned to HES 130/0.42 versus Ringer's acetate, but we could not reject a 24% relative increased or a 4% relative decreased mortality at 1 year with HES at the 95% confidence level. (lsh.is)
  • Single-arm, open-label, trial of drotrecogin alfa (activated) treatment in severe sepsis patients. (nih.gov)
  • Patients with known or suspected infection, three or four systemic inflammatory response syndrome criteria, and one or more sepsis-induced organ dysfunctions. (nih.gov)
  • ENHANCE patients treated within 0-24 hrs from their first sepsis-induced organ dysfunction had lower observed mortality rate than those treated after 24 hrs (22.9% vs. 27.4%, p = .01). (nih.gov)
  • MATERIALS AND METHODS @# Patients with severe sepsis and septic shock admitted to the PICU were identified through discharge codes . (bvsalud.org)
  • Patients: Children less than 18 years with severe sepsis enrolled in the Sepsis Prevalence, Outcomes, and Therapies study (n = 567). (elsevier.com)
  • OBJECTIVES: To investigate the impact of body temperature on disease severity, implementation of sepsis bundles, and outcomes in severe sepsis patients. (elsevier.com)
  • Many patients meeting criteria for severe sepsis are not given a sepsis-related diagnosis by emergency physicians (EP). (westjem.com)
  • This study 1) compares emergency department (ED) interventions and in-hospital outcomes among patients with severe sepsis, based on the presence or absence of sepsis-related diagnosis, and 2) assesses how adverse outcomes relate to three-hour sepsis bundle completion among patients fulfilling severe sepsis criteria but not given a sepsis-related diagnosis. (westjem.com)
  • We performed a retrospective cohort study using patients meeting criteria for severe sepsis at two urban, academic tertiary care centers from March 2015 through May 2015. (westjem.com)
  • Of 418 patients identified with severe sepsis we excluded 54, leaving 364 patients for analysis: 121 "Physician Diagnosis" and 243 "Consensus Criteria. (westjem.com)
  • 24 hours in patients without a sepsis diagnosis. (westjem.com)
  • Physician Diagnosis" patients more frequently received sepsis-specific interventions and had a higher incidence of mortality. (westjem.com)
  • Consensus Criteria" patients had infrequent adverse outcomes regardless of three-hour bundle compliance. (westjem.com)
  • 5 In 2015 these recommendations were integrated into the Center for Medicare and Medicaid Services (CMS) sepsis quality measure, NQF# 0500, which mandates three- and six-hour care bundles for patients with severe sepsis. (westjem.com)
  • This measure includes all patients with an International Classification of Diseases, Tenth Revision, Clinical Manageme nt ( ICD-10 ) diagnosis of "severe sepsis" or "septic shock," as well as "sepsis," if patients demonstrate two or more systemic inflammatory response syndrome (SIRS) criteria, new sepsis-related organ dysfunction, and suspected infection-the definition of severe sepsis in the 1992 Consensus guidelines. (westjem.com)
  • More patients meet criteria for sepsis than those who are assigned a categorical sepsis diagnosis by emergency physicians (EP). (westjem.com)
  • 8 This discrepancy raises the possibility that EPs under-identify patients who could benefit from early and aggressive treatment, delaying time-sensitive care for these critically ill patients, and negatively affect patient outcomes in sepsis. (westjem.com)
  • The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients. (ufl.edu)
  • We performed a single center, prospective observational cohort study of Surgical ICU patients with severe sepsis/septic shock. (ufl.edu)
  • Aged septic patients biomarker trajectories suggestive of persistent immunosuppression (Absolute lymphocyte count, sPDL-1) and catabolism (Urine 3MH-Cr ratio, IGF, IGF1BP3, albumin) out to 28 days after sepsis. (ufl.edu)
  • Aged, critically ill surgical patients have greater organ dysfunction, and incidence of adverse clinical outcomes after sepsis. (ufl.edu)
  • Paramedics frequently come into contact with patients with sepsis, and are well placed to provide early diagnosis and treatment. (isrctn.com)
  • This small study aims to find out whether paramedics can collect blood samples and give antibiotics to patients with severe sepsis. (isrctn.com)
  • That paramedics are able take blood cultures from and provide intravenous antibiotics to patients with severe sepsis in the prehospital environment before the patients arrives at the emergency department. (isrctn.com)
  • 7 , 8 , 9 According to data 10 from two hospital cohorts, 34.7% to 55.9% of American patients who died in hospitals between 2010 and 2012 had sepsis at the time of their death (depending on which inpatient population they were in). (lewrockwell.com)
  • To describe characteristics of patients with sepsis, CDC and partners conducted a retrospective chart review in four New York hospitals. (cdc.gov)
  • Random samples of medical records from adult and pediatric patients with administrative codes for severe sepsis or septic shock were reviewed. (cdc.gov)
  • Overall, 72% of patients had a health care factor during the 30 days before sepsis admission or a selected chronic condition likely to require frequent medical care. (cdc.gov)
  • 25%) patients with sepsis died, including 65 (26%) adults and 17 (22%) infants and children. (cdc.gov)
  • CDC, in partnership with organizations representing clinicians, patients, and other stakeholders, is launching a comprehensive campaign to demonstrate that prevention of infections that cause sepsis, and early recognition of sepsis, are integral to overall patient safety. (cdc.gov)
  • Sepsis is associated with characteristics, comorbidities, and potential opportunities for high morbidity and mortality ( 1 - 4 ) and accounted for $23.7 infection prevention among patients with sepsis. (cdc.gov)
  • Patients were eligible focused on improving outcomes by promoting protocol-driven for inclusion if they had a hospital admission during approaches that facilitate early recognition and treatment ( 8 ). (cdc.gov)
  • Clinical Modification (ICD-9-CM) discharge diagnosis codes clinicians, patients, and families about prevention of infections for severe sepsis (995.92) or septic shock (785.52) were used that can lead to sepsis. (cdc.gov)
  • We conducted this study to evaluate the clinical outcomes of patients with severe sepsis and septic shock who were treated with ketamine for endotracheal intubation. (signavitae.com)
  • A single-center, retrospective study was carried out to compare the outcomes of patients with severe sepsis and septic shock who received a ketamine or non-ketamine agent for rapid sequence intubation (RSI). (signavitae.com)
  • We analyzed the sepsis registry for adult patients who presented to the emergency department (ED), met the criteria for severe sepsis or septic shock, and underwent endotracheal intubation between August 2008 and March 2014. (signavitae.com)
  • For patients with severe sepsis and septic shock who were intubated using RSI, we found no significant difference in 28-day mortality between those who received ketamine as a sedative agent and those who received alternative sedatives. (signavitae.com)
  • According to recent large studies, approximately 30%-95% of critically ill patients with sepsis require intubation. (signavitae.com)
  • 6,7) However, the choice of appropriate sedatives for RSI in critically ill patients with sepsis is a challenging task. (signavitae.com)
  • However, concerns have been raised regarding potential detrimental effects of etomidate-related adrenal insufficiency in septic patients, although the causal relationship between adrenal insufficiency and outcome remains inconclusive. (signavitae.com)
  • 9) Although the current opinion is that ketamine is a good alternative to etomidate for intubation in critically ill patients with sepsis, few studies have specifically investigated the outcomes of patients with severe sepsis or septic shock treated with ketamine. (signavitae.com)
  • A retrospective, single-center cohort study of patients with severe sepsis or septic shock who were intubated using the RSI technique was conducted at Samsung Medical Center (a 1,960-bed, university-affiliated tertiary teaching hospital), located in a metropolitan city. (signavitae.com)
  • We conducted a multicentre, prospective, observational study of the prevalence of patients with sepsis or severe sepsis on the general wards and Emergency Departments (ED) in Wales. (mendeley.com)
  • To be eligible for inclusion, patients had to have a high clinical suspicion of an infection, together with a systemic inflammatory response (sepsis) and evidence of acute organ dysfunction and/or shock (severe sepsis). (mendeley.com)
  • 146 patients had sepsis and 144 patients had severe sepsis. (mendeley.com)
  • Combined prevalence of sepsis and severe sepsis was 5.5% amongst all in-patients. (mendeley.com)
  • Patients with sepsis had significantly higher NEWS scores (3 IQR 3-4 for non-sepsis and 4 IQR 3-6 for sepsis patients, respectively). (mendeley.com)
  • Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. (springer.com)
  • Management of severe sepsis in patients admitted to Asian intensive care units: prospective cohort study. (springer.com)
  • Wheeler AP, Bernard GR. Treating patients with severe sepsis. (medscape.com)
  • OBJECTIVE Hypoglycemia is associated with adverse outcomes in mixed populations of patients in intensive care units. (diabetesjournals.org)
  • A number of risk factors for hypoglycemia in critically ill patients, including continuous venovenous hemofiltration, inotropic support, or sepsis are absent or less common outside of the ICU ( 5 ). (diabetesjournals.org)
  • Several studies have demonstrated that the relationship of elevated blood glucose with clinical outcomes may be quantitatively and qualitatively different between patients with and without a diagnosis of diabetes. (diabetesjournals.org)
  • Because the majority of hospitalized patients with diabetes are treated in the general ward, it is important to understand the relationship of hypoglycemia in diabetic patients in the general ward with clinical outcomes. (diabetesjournals.org)
  • To this end, we examined whether hypoglycemia in patients with diabetes hospitalized in the general ward is associated with adverse outcomes. (diabetesjournals.org)
  • We conducted a retrospective cohort study to investigate whether hypoglycemia in diabetic patients hospitalized in the general ward is associated with poor clinical outcomes. (diabetesjournals.org)
  • The rationale behind its lack of inclusion in the diagnostic criteria for sepsis is that a culprit organism goes unidentified in up to half of patients who present with sepsis, and a positive culture result is not required to make a decision regarding treatment with empiric antibiotics. (medscape.com)
  • A recent study led by Boston University School of Medicine (BUSM) shows that "practice may make perfect" when it comes to caring for patients with severe sepsis. (medicalxpress.com)
  • By improving the treatment of those critically ill with sepsis, the consortium's work will have enormous implications for the thousands of patients who suffer from this infection," said NIH Director Elias A. Zerhouni, M.D. (medicalxpress.com)
  • Following a year-long period of establishing and training sepsis teams, the consortium plans to treat early severe sepsis in nearly 2,000 patients, enrolling patients over a two- to three-year period. (medicalxpress.com)
  • The scientists aim to develop a blueprint, complete with lists of tips and traps, to help hospitals adopt standardized methods for evaluating and treating early sepsis patients. (medicalxpress.com)
  • Bet 2: Does intravenous vitamin C improve mortality in patients with severe sepsis? (bmj.com)
  • A shortcut review was carried out to establish whether the use of intravenous vitamin C can reduce mortality or morbidity in patients diagnosed in the early phases of severe sepsis. (bmj.com)
  • There have been 2 studies in a tertiary care pediatric ED that examined adherence to national guidelines for patients with sepsis after a quality improvement (QI) intervention. (aappublications.org)
  • Patients with single organ dysfunction due to sepsis (e.g., lung) and recent surgery (within 30 days before drotrecogin use) have had a higher mortalitity rate in the ADDRESS study. (wikipedia.org)
  • A recent study in pediatric patients with severe sepsis had to be discontinued (lack of positive results and severe side-effects). (wikipedia.org)
  • Detailed data regarding underlying conditions, health care factors, types of infections, and pathogens most commonly associated with sepsis could guide development of programs to inform clinicians, patients, and families about prevention of infections that can lead to sepsis. (cdc.gov)
  • To inform sepsis initiatives and health communication efforts, CDC partnered with the New York State Department of Health and Emerging Infections Program to perform a medical record assessment to describe clinical characteristics, comorbidities, and potential opportunities for infection prevention among patients with sepsis. (cdc.gov)
  • As severe sepsis and septic shock are high mortality conditions, it is important to understand how sex and gender affect these patients in order to improve both short-term and long-term outcomes. (amwa-doc.org)
  • Host derived biomarkers of inflammation, apoptosis, and endothelial activation are associated with clinical outcomes in patients with bacteremia and sepsis regardless of microbial etiology. (semanticscholar.org)
  • Biomarkers of endothelial activation/dysfunction distinguish sub-groups of Ugandan patients with sepsis and differing mortality risks. (semanticscholar.org)
  • Spouses of severe-sepsis patients at high risk of depression, U-M s. (bio-medicine.org)
  • ANN ARBOR, Mich. Severe sepsis, a body's dangerous defensive response against an infection, not only diminishes the quality of life for patients it puts their spouses at a greater risk of depression, a joint University of Michigan Health System and University of Washington School of Medicine study shows. (bio-medicine.org)
  • We know that patients who survive sepsis face many new problems, but we know little about the emotional toll it takes on patients' loved ones," says senior author Theodore J. Iwashyna, M.D., Ph.D., assistant professor of internal medicine at U-M and who also works with the Institute of Social Research and the VA Center for Clinical Management Research. (bio-medicine.org)
  • Previous studies have found that Black adults and uninsured patients have higher mortality rates for sepsis. (eurekalert.org)
  • Sepsis has been a common and a serious problem among most of the surgical patients and most of the patients in the emergency department. (topwritingservice.com)
  • The goal of the sepsis screening tool is to reduce preventable harm to patients with sepsis through the early recognition of sepsis, improved time to the administration of antibiotics, and the appropriate fluid resuscitation. (topwritingservice.com)
  • The aim of this trial was to determine the clinical and pharmacokinetic differences between continuous and intermittent dosing in patients with severe sepsis. (biomedsearch.com)
  • Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis an. (biomedsearch.com)
  • Pharmacokinetics of omega-3 fatty acids in patients with severe sepsis compared with healthy volunteers: A prospective cohort study. (bioportfolio.com)
  • This is prospective study to assess the pharmacodynamics (t>MIC) of 4.5 g every 6 h of piperacillin/tazobactam in patients with early phase of severe sepsis/septic shock following administ. (bioportfolio.com)
  • This issue reviews the use of novel diagnostic tools such as procalcitonin, C-reactive protein, and RNA biosignatures as well as new risk stratification tools such as the Step-by-Step approach and the Pediatric Emergency Care Applied Research Network prediction rule to determine which febrile young infants require a full sepsis workup and to guide the management of these patients in the emergency department. (ebmedicine.net)
  • We evaluated the association between severity of sepsis and in-hospital mortality in 150 patients with non-surgical sepsis at a regional referral hospital in Uganda. (ajtmh.org)
  • In-hospital mortality occurred in 5 of 52 (9.6%) patients with sepsis, 24 of 71 (33.8%) patients with severe sepsis, and 16 of 27 (59.3%) patients with septic shock. (ajtmh.org)
  • A prospective observational study of patients with severe sepsis was performed. (pubmedcentralcanada.ca)
  • Mononuclear cells were isolated from 48 patients with severe sepsis. (pubmedcentralcanada.ca)
  • To compare estimates of the incidence and mortality of sepsis and septic shock among patients in Australian intensive care units (ICUs) according to clinical diagnoses or binational intensive care database (ANZICS CORE) methodology. (mja.com.au)
  • The known The accuracy of estimates of the incidence and mortality of sepsis in patients in Australian intensive care units (ICUs) by the Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation is unknown. (mja.com.au)
  • Hamad Medical Corporation (HMC) is launching a new sepsis program to benefit patients across all HMC facilities who have been diagnosed with sepsis. (albawaba.com)
  • This program is designed to provide a safety net system to prevent these patients from experiencing the complications of sepsis, such as end-organ failure and septic shock. (albawaba.com)
  • As part of the awareness-raising activities and to mark World Sepsis Day, HMC's Sepsis Program team organized an annual multi-disciplinary symposium for healthcare professionals involved in the care of patients with sepsis. (albawaba.com)
  • The efficacy and safety of the administration of recombinant human thrombopoietin (rhTPO) in sepsis patients with thrombocytopenia were still inconclusive. (frontiersin.org)
  • To investigate whether rhTPO is a benefit for sepsis patients with thrombocytopenia. (frontiersin.org)
  • However, SRT as a complication closely related to the prognosis of sepsis patients, the mechanism and treatment of which are still controversial. (frontiersin.org)
  • This study is a prospective multi-centre randomized trial to compare the effect of long-term mild hypothermia versus routine normothermic intensive management in patients with severe traum. (bioportfolio.com)
  • We suggest that PLD2 in neutrophils is essential for the pathogenesis of experimental sepsis and that pharmaceutical agents that target PLD2 may prove beneficial for septic patients. (rupress.org)
  • Our objective was to determine whether sex and age are associated with differences in admission practices, processes of care and clinical outcomes for critically ill patients. (cmaj.ca)
  • We hypothesized that age and sex might be associated with differences in admission practices, processes of care and clinical outcomes for critically ill patients, and we explored these relations over a 2-year period in a diverse sample of hospitals in Ontario. (cmaj.ca)
  • Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis. (otago.ac.nz)
  • This knowledge has improved diagnostic techniques and introduced new therapeutic agents into the standard management of patients with severe sepsis/septic shock. (springer.com)
  • Epidemiology of sepsis and infection in ICU patients from international multi-center cohort study. (springer.com)
  • Although short courses of high-dose glucocorticoids decreased survival during sepsis, a 5- to 7-day course of physiologic hydrocortisone doses with subsequent tapering increases survival rate and shock reversal in patients with vasopressor-dependent septic shock. (annals.org)
  • Over that period, volunteer sites entered sepsis bundle indicator data into the SSC database for 29,470 severe sepsis patients. (sccm.org)
  • Achieving 100% compliance with sepsis bundle indicators in patients with severe sepsis is unlikely due to a combination of patient pathophysiology not amendable to intervention, the large number of health care providers that must be trained, and surges in patient volume. (sccm.org)
  • The aim of this study was to assess the prognostic value of the serum total bilirubin (TBIL) level in pediatric patients with sepsis-associated liver injury (SALI). (hindawi.com)
  • Although the mortality rate for sepsis has declined over the past decade, it remains high in critically ill patients [ 2 ]. (hindawi.com)
  • SALI is a significant predictive sign of poor prognosis in adult patients with sepsis [ 6 ]. (hindawi.com)
  • In addition, the elevated serum bilirubin level within 72 hours after admission is associated with an increased risk of mortality in the adult patients with severe sepsis and septic shock [ 10 ]. (hindawi.com)
  • Patients with sepsis were diagnosed based on the International Pediatric Sepsis consensus conference in 2005 [ 11 ] and Surviving Sepsis Campaign International Guidelines in 2012 [ 12 ]. (hindawi.com)
  • Brachial artery reactivity in patients with severe sepsis: an observational study. (rochester.edu)
  • The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis. (rochester.edu)
  • Sepsis patients in the emergency department: Stratification using the Clinical Impression Score, Predisposition, Infection, Response and Organ dysfunction score or quick Sequential Organ Failure Assessment score? (rug.nl)
  • OBJECTIVE: The aim of this study was to compare the stratification of sepsis patients in the emergency department (ED) for ICU admission and mortality using the Predisposition, Infection, Response and Organ dysfunction (PIRO) and quick Sequential Organ Failure Assessment (qSOFA) scores with clinical judgement assessed by the ED staff. (rug.nl)
  • RESULTS: We included 193 patients: 103 presented with sepsis, 81 with severe sepsis and nine with septic shock. (rug.nl)
  • CONCLUSION: Clinical judgement is a fast and reliable method to stratify between ICU and general ward admission in ED patients with sepsis. (rug.nl)
  • Not only is the mortality severe, but studies have demonstrated increasing costs of care for these patients [1-4]. (epmonthly.com)
  • A great deal of literature exists on sepsis and providing state of the art care in the ED. As emergency providers, we pride ourselves on resuscitating the sick patient, and septic patients can rapidly decline clinically. (epmonthly.com)
  • According to the SIRS naysayers, one of the major issues with SIRS is that it misses 1 out of 8 patients with diagnosed severe sepsis (notice this is not sepsis, but severe sepsis), reported in a recent study from the NEJM [3]. (epmonthly.com)
  • Early clinical trials of recombinant human activated protein C (rhAPC) for severe sepsis excluded patients at high risk of bleeding. (dovepress.com)
  • and mortality of patients receiving rhAPC for severe sepsis at our institution. (dovepress.com)
  • A retrospective study was performed for all patients receiving rhAPC for treatment of severe sepsis at a tertiary academic medical center from January 2002 to June 2009. (dovepress.com)
  • Background: Severe sepsis is recognized as an inflammatory response causing organ dysfunction in patients with infection. (uib.no)
  • Objective We sought to compare the quick sequential organ failure assessment (qSOFA) to systemic inflammatory response syndrome (SIRS), severe sepsis criteria and lactate levels for their ability to identify ED patients with sepsis with critical illness. (bmj.com)
  • Main results Of 3743 enrolled patients, 512 (13.7%) had the primary composite outcome. (bmj.com)
  • Conclusion For patients admitted from the ED with infectious disease diagnoses, qSOFA criteria performed as well or better than SIRS criteria, severe sepsis criteria and lactate levels in predicting critical illness. (bmj.com)
  • The Society of Critical Care Medicine and the European Society of Intensive Care Medicine have recently proposed the quick sequential organ failure assessment (qSOFA) criteria as replacements for traditional sepsis and severe sepsis criteria to identify critically ill patients outside of the intensive care unit. (bmj.com)
  • Early identification of patients who are critically ill or may have poor outcomes is a cornerstone of sepsis patient management. (bmj.com)
  • Introduction Sepsis is a leading cause of mortality in critically ill patients. (bmj.com)
  • The aim of this systematic review is to summarise the available evidence to assess the role of sex as a prognostic factor in patients with sepsis managed in the intensive care unit (ICU). (bmj.com)
  • Methods and analysis This is a systematic review protocol of prognostic studies of sex in patients with sepsis managed in the ICU. (bmj.com)
  • Absence of fever is associated with suppressed HLA-DR expression over time, a finding suggestive of monocyte dysfunction in sepsis, as well as worse clinical outcomes. (ovid.com)
  • [email protected]#Cumulative %FO within the first 5 days of PICU stay was consistently and independently associated with poor clinical outcomes in children with severe sepsis and septic shock . (bvsalud.org)
  • We compared age-defined cohorts to determine differences in patient characteristics, biomarker profiles and clinical outcomes. (ufl.edu)
  • Hyperglycemia is associated with adverse clinical outcomes, and randomized controlled trials in intensive care units (ICUs) have shown that aggressive treatment of elevated blood glucose improves outcomes. (diabetesjournals.org)
  • The assessed clinical outcomes were clinical response 7-14 days after study drug cessation, ICU-free days at day 28 and hospital survival. (biomedsearch.com)
  • It is generally believed that access to an intensive care unit (ICU), the care received and subsequent clinical outcomes are determined primarily by need and severity of illness. (cmaj.ca)
  • 7 , 8 Previous studies from various jurisdictions have suggested that there may be sex-based differences in critical illness and ICU admission patterns, 3 , 4 , 6 , 9 although there have been no consistent findings of sex-based differences in the provision of care or clinical outcomes. (cmaj.ca)
  • Early detection and evaluation of SALI are important for improving the clinical outcomes. (hindawi.com)
  • We defined severe sepsis as documented infection and acute organ dysfunction using criteria based on the International Classification of Diseases, Ninth Revision, Clinical Modification. (nih.gov)
  • Sepsis associated to a organ dysfunction. (clinicaltrials.gov)
  • Immune dysfunction may be a potential link between failure to mount a fever and poor outcomes. (ovid.com)
  • It is considered severe when it is associated with acute organ dysfunction. (biomedcentral.com)
  • The time elapsed between the onset of organ dysfunction and initiation of therapeutic intervention can be quite long, and this represents an important determinant of survival in cases of severe sepsis and septic shock . (bvsalud.org)
  • Multivariate analysis adjusting for presence of comorbidities, Pediatric Index of Mortality (PIM) 2 score and multiorgan dysfunction were used to determine the association between cumulative %FO over 5 days and outcomes. (bvsalud.org)
  • Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. (westjem.com)
  • The road ahead will lead to a more robust understanding of both organ dysfunction and the dysregulated host response in sepsis. (springer.com)
  • Because systemic inflammatory response syndrome (SIRS), sepsis, septic shock, and multiple organ dysfunction syndrome (MODS) represent a clinical continuum (see Overview), the specific features exhibited in any given case depend on where the patient falls on that continuum. (medscape.com)
  • Many different infections can lead to sepsis, a serious and often fatal clinical syndrome that is characterized by organ dysfunction and can be difficult to diagnose ( 1 - 3 ). (cdc.gov)
  • Severe sepsis is the acute organ dysfunction which is secondary to infection. (topwritingservice.com)
  • Severe sepsis is one of the fulminant diseases which can cause dysfunction in most of the body systems and in most cases, it is reported to cause life-threatening homeostasis loss and at the same time, it can also lead to cardiovascular failure, renal system failure which in most cases may be fatal. (topwritingservice.com)
  • When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. (bioportfolio.com)
  • Acute neurological dysfunction during severe SEPSIS in the absence of direct brain infection characterized by systemic inflammation and BLOOD BRAIN BARRIER perturbation. (bioportfolio.com)
  • In the multivariate analysis, the identification of severe sepsis (adjusted hazard ratio [AHR] = 2.9, 95% confidence interval [CI] = 1.0-8.2, P = 0.04), septic shock (AHR = 5.7, 95% CI = 1.6-20.3, P = 0.007), and dysfunction of three or more organs (AHR = 2.9, 95% CI = 1.1-7.3, P = 0.03) increased the risk of in-hospital mortality. (ajtmh.org)
  • Adding aggregate organ dysfunction to the multivariate equation that included the sepsis category statistically significantly improved the model, but the opposite did not. (ajtmh.org)
  • The SOFA (Sepsis-related organ failure assessment) score to describe organ dysfunction/failure. (ajtmh.org)
  • 5 As there are no definitive tissue or serological tests for sepsis, the gold standard for diagnosis is clinical identification of organ dysfunction caused by infection. (mja.com.au)
  • Two or more of these equals SIRS, and two or more with a source of infection equals sepsis.1,2 Severe sepsis is sepsis with organ dysfunction, and septic shock is sepsis with hypotension, defined by systolic blood pressure less than 90 mm Hg, unresponsive to fluid rehydration. (epmonthly.com)
  • However, associated organ dysfunction does predict worse outcome. (epmonthly.com)
  • To evaluate diagnostic tests for infection in community-acquired sepsis and severe sepsis in NE Thailand. (clinicaltrials.gov)
  • Fungal infection is increasingly common in critical illness with severe sepsis, but the influence of invasive fungal infection (IFI) on severe sepsis is not well understood. (biomedcentral.com)
  • Sepsis is the body's systemic inflammatory response to infection. (biomedcentral.com)
  • Severe sepsis and septic shock are severe illnesses caused by infection that can lead to death through progression of systemic inflammatory response syndrome and multiple organ failure [ 1 , 2 ]. (ceemjournal.org)
  • Sepsis is a rare but serious complication of an infection. (isrctn.com)
  • Also known as blood poisoning among lay people, sepsis 1 is a last-ditch effort by your immune system to fight an infection in your body, which can lead to multiple organ failure and death unless promptly treated. (lewrockwell.com)
  • The most common types of infection triggering sepsis are respiratory and urinary tract infections. (lewrockwell.com)
  • Increasing the dosage of daptomycin may be advantageous in severe infection by enhancing bactericidal activity and pharmacodynamics. (biomedcentral.com)
  • Sepsis is a serious and often fatal clinical syndrome, resulting from infection. (cdc.gov)
  • Pneumonia was the most common infection leading to sepsis. (cdc.gov)
  • Infection prevention strategies (e.g., vaccination, reducing transmission of pathogens in health care environments, and appropriate management of chronic diseases) are likely to have a substantial impact on reducing sepsis. (cdc.gov)
  • The road ahead will lead to improvements in the diagnosis of both infection and sepsis. (springer.com)
  • Although sepsis is associated with bacterial infection , bacteremia is not a necessary ingredient in the activation of the inflammatory response that results in sepsis. (medscape.com)
  • That's not the case if you have a body-wide infection known as sepsis, which can be fatal within a few hours and is often not diagnosed until it is too late. (medicalxpress.com)
  • Sepsis occurs when the body's normal reaction to an infection goes into overdrive, causing widespread inflammation and dramatic changes in body temperature, blood pressure, breathing, and heart rate. (medicalxpress.com)
  • First, the effect of gender on the epidemiology of sepsis is influenced by factors including age, source of infection, and comorbidities. (amwa-doc.org)
  • 1 , 2 In this study, mortality from severe sepsis was also lower for women but this gender difference was explained by age, comorbidities, and site of infection. (amwa-doc.org)
  • Sepsis happens when an infection such as pneumonia or urinary tract in. (bio-medicine.org)
  • Sepsis happens when an infection such as pneumonia or urinary tract infection throws off the immune system, prompting it to attack the body it's designed to protect. (bio-medicine.org)
  • The new study is one of the first to identify disparities in outcomes for severe sepsis - a life-threatening reaction caused by the immune system overreacting to an infection - in children outside the neonatal period based on race/ethnicity and insurance status. (eurekalert.org)
  • Sepsis is a severe clinical syndrome which is defined by the presence of infection and systematic inflammatory response. (topwritingservice.com)
  • Sepsis is associated with a deflection of inflammatory and coagulative parameters, since some clotting factors are known to be involved in the host's defense against infection and inflammation. (bioportfolio.com)
  • Sepsis is a life-threatening condition that arises when the body's response to an infection damages its own tissues and organs and if not recognized early and treated promptly, can lead to shock, multiple organ failure and death. (albawaba.com)
  • Diagnosis of infection in sepsis: an evidence-based review. (springer.com)
  • Sepsis, the leading cause of death in intensive care units, reflects a detrimental host response to infection in which bacteria or LPS act as potent activators of immune cells, including monocytes and macrophages. (jimmunol.org)
  • Hyperbilirubinemia is a risk factor for infection in the surgical intensive care unit (ICU) [ 8 ], and an admission bilirubin of greater than 2 mg/dL was independently associated with the development of sepsis-related acute respiratory distress syndrome (ARDS) and mortality in sepsis [ 9 ]. (hindawi.com)
  • Any pregnant or recently pregnant woman (up to 6 weeks postpartum) diagnosed with severe sepsis (irrespective of the source of infection). (ox.ac.uk)
  • Two or more of these equals SIRS, and two or more with a source of infection equals sepsis, according to the "old" definition [1,2]. (epmonthly.com)
  • Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. (wikipedia.org)
  • Sepsis is caused by an inflammatory immune response triggered by an infection. (wikipedia.org)
  • Previously, a sepsis diagnosis required the presence of at least two systemic inflammatory response syndrome (SIRS) criteria in the setting of presumed infection. (wikipedia.org)
  • METHODS: A total of 421 severe sepsis-related ALI subjects in the Consortium to Evaluate Lung Edema Genetics from seven teaching hospitals between 2002 and 2008 were included in our study. (biomedsearch.com)
  • The road ahead will have increased screening and better methods for identifying sepsis. (springer.com)
  • 7 , 8 A major United States study 9 recently found that estimates of the incidence of sepsis based on ICD coding ranged between half and twice the actual clinical rate, depending on the methods applied. (mja.com.au)
  • We will conduct a search strategy based on the population (sepsis), the prognostic factor (sex), the outcome of interest (mortality) and prognostic study methods. (bmj.com)
  • Shah and a multi-disciplinary team at Le Bonheur Children's Hospital have developed an algorithm that continuously screens hospital electronic medical records for signs of sepsis. (lebonheur.org)
  • One of our top priorities was to ensure that staff, and also the public, are able to recognize the earliest signs of sepsis in order to provide fast and effective treatment," said Dr Ahmed Labib, Senior Consultant Intensivist and Anesthetist and HMC's Sepsis Program Working Group Chair, Medical Intensive Care Unit, Hamad General Hospital. (albawaba.com)
  • 9 - 12 Three recent studies conducted in tertiary pediatric emergency department (ED) settings have demonstrated barriers to the care of children with sepsis, resulting in poor adherence to the rapid administration of IV fluids, vasoactive agents, and antibiotics. (aappublications.org)
  • Inflammatory and coagulatory parameters linked to survival in critically ill children with sepsis. (bioportfolio.com)
  • Fluid bolus therapy (FBT) has long been the central component of resuscitation of children with sepsis ( 4 ). (frontiersin.org)
  • Results of these animal studies revealed that clarithromycin inhibited the evolution of the systemic inflammatory response syndrome (SIRS) acting at the cellular level of blood monocytes and that its effect was expressed when administered after induction of sepsis. (clinicaltrials.gov)
  • Systemic inflammatory response syndrome (SIRS) and sepsis are common clinical entities, consisting of a continuum of clinical syndromes. (epmonthly.com)
  • For nearly two decades, clinicians have used systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis and septic shock as the primary terms (with corresponding criteria) to gauge severity of illness and guide patient management. (bmj.com)
  • Sepsis associated to hypotension despite adequate fluid resuscitation, with hypoperfusion including lactic acidosis, oliguria and acute alteration of consciousness. (clinicaltrials.gov)
  • To determine factors associated with inflammatory response, organ failure, and mortality in community-acquired sepsis and severe sepsis in NE Thailand, including causes of sepsis, sepsis resuscitation, antimicrobial treatment and genetic factors. (clinicaltrials.gov)
  • Septic shock is severe sepsis plus hypotension which is not reversed with fluid resuscitation. (topwritingservice.com)
  • The main importance is the improving of the early diagnosis of severe sepsis and septic shock and the improving of the timeliness of the implementation of sepsis resuscitation bundle and also the improving of the patient outcomes including mortality rate and the cost of hospitalization. (topwritingservice.com)
  • The emergence of evidence demonstrating harm associated with FBT has led to a re-evaluation of its role in sepsis resuscitation. (frontiersin.org)
  • Multivariable logistic and linear regression analyses were performed to assess associations between timely administration of antibiotics and outcomes, including hospital mortality, 48-hour change in Sequential Organ Failure Assessment (SOFA) score (delta SOFA), and hospital length of stay (LOS). (ceemjournal.org)
  • A U.S. government report 13 , 14 published in 2016 found sepsis was the most expensive condition treated in the U.S., racking up $23.7 billion in health care costs each year. (lewrockwell.com)
  • 9,816 children with severe sepsis were included in the analysis using data from the 2016 Kids' Inpatient Database (KID), which records 80% of paediatric discharges across 47 states. (eurekalert.org)
  • The day-long symposium, held on 26 September 2016, featured local and international experts who shared international best practice approaches to sepsis care. (albawaba.com)
  • 3 We have recently reported that the incidence of severe infections in children that require admission to an intensive care unit (ICU) was increasing in Australia and New Zealand, 4 consistent with recent reports from the United States. (mja.com.au)
  • This study will describe, on a population level, the incidence of severe maternal sepsis in the UK, associated risk factors, causative organisms, management and outcomes and investigate whether any factors are associated with poor outcomes. (ox.ac.uk)
  • The aim of this study, therefore, is to carry out a population-based case-control study using UKOSS to estimate the incidence of severe maternal sepsis in the UK, to investigate and quantify the associated risk factors, causative organisms, management and outcomes and to explore whether any factors are associated with poor outcomes. (ox.ac.uk)
  • What is the incidence of severe maternal sepsis in the UK? (ox.ac.uk)
  • The incidence of severe sepsis and subsequent mortality among individuals with community-acquired pneumonia (CAP) rises sharply after the age of 65 [1] , [2] . (plos.org)
  • The Surviving Sepsis Campaign Guideline 2008 [ 1 ] recommends starting appropriate antibiotic therapy within 1 hour after making the diagnosis of septic shock. (biomedcentral.com)
  • Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock. (biomedcentral.com)
  • MEASUREMENTS AND MAIN RESULTS: Compliance with the bundles proposed in the Surviving Sepsis Campaign Guidelines 2012, in-hospital mortality, disposition after discharge, and the number of ICU and ventilator-free days were evaluated. (elsevier.com)
  • Surviving sepsis campaign: association between performance metrics and outcomes in a 7.5-year study. (springer.com)
  • Outcomes of the surviving sepsis campaign in intensive care units in the USA and Europe: a prospective cohort study. (springer.com)
  • In 2010, the Surviving Sepsis Campaign (SSC) Phase III results showed that sepsis bundle compliance was associated with improved outcomes. (sccm.org)
  • In the 2012 Surviving Sepsis Campaign Guidelines, the sepsis bundles were reduced from 6- and 24-hour to 3- and 6-hour bundles. (sccm.org)
  • 1 As clinicians, we need to align our thoughts and actions to strive for early identification and increase sepsis bundle compliance as a means to improve patient outcomes. (sccm.org)
  • Importance: Checklists have been shown to improve patient outcomes in surgery. (uib.no)
  • Epidemiology of sepsis syndrome in 8 academic medical centers. (medscape.com)
  • 2 The WHO noted that data on the epidemiology of sepsis are incomplete for many countries, and almost totally lacking for low and middle income countries. (mja.com.au)
  • Epidemiology of sepsis in the United States from 1979-2000. (springer.com)
  • Procurement of low cost and high impact treatments like intravenous fluids and empiric antibiotics may help decrease sepsis-associated mortality in resource-constrained settings. (elsevier.com)
  • The idea for the application of intravenous clarithromycin as immunomodulatory therapy for the management of sepsis has been evolved on in vitro results showing that concentrations close to 10μg/ml may refrain biosynthesis of pro-inflammatory cytokines by inhibiting the activation of the translation factor NF-κB. (clinicaltrials.gov)
  • In 2017, news emerged about a critical care physician who claimed to have discovered a simple and inexpensive way to treat sepsis using an intravenous (IV) cocktail of vitamin C and thiamine (vitamin B1) in combination with the steroid hydrocortisone. (lewrockwell.com)
  • If central intravenous (IV) line sepsis is suspected, remove the line and send the tip for semiquantitative bacterial culture. (medscape.com)
  • Quality improvement (QI) interventions, including repeated plan-do-study-act cycles, were used to improve adherence to a 5-component sepsis bundle, including timely (1) recognition of septic shock, (2) vascular access, (3) administration of intravenous (IV) fluid, (4) antibiotics, and (5) vasoactive agents. (aappublications.org)
  • Sepsis is usually treated with intravenous fluids and antibiotics . (wikipedia.org)
  • Sepsis requires immediate treatment with intravenous fluids and antimicrobials. (wikipedia.org)
  • This is an observational study to identify the aetiology and factors associated with outcome of community-acquired sepsis and severe sepsis in Northeast Thailand. (clinicaltrials.gov)
  • The road ahead will lead to an increased understanding of the global burden of sepsis. (springer.com)
  • Accurately quantifying the incidence and disease burden of sepsis is difficult. (mja.com.au)
  • Consequently, routinely collected data are analysed to estimate the incidence and burden of sepsis, generally based on International Classification of Disease (ICD) coding of cases. (mja.com.au)
  • The worldwide burden of sepsis in pediatric intensive care in terms of morbidity and mortality remains high and is a key healthcare priority ( 1 - 3 ). (frontiersin.org)
  • There is considerable evidence that elevated plasma homocysteine levels are associated with a prothrombotic milieu, whereas activation of the coagulation cascade is an important component of the pathogenesis of sepsis. (cdc.gov)
  • A functional role for PLD2 in the pathogenesis of sepsis has yet to be explored. (rupress.org)
  • Opal SM, Esmon C. Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis. (springer.com)
  • Remarkable progress has been made in understanding the pathophysiology of sepsis. (springer.com)
  • Sepsis-induced lymphocyte apoptosis plays a fundamental role in the pathophysiology of sepsis. (pubmedcentralcanada.ca)
  • This chapter reviews the remarkable recent advances in the understanding of the molecular basis that underlies the pathophysiology of sepsis. (springer.com)
  • Sepsis affected about 49 million people in 2017, with 11 million deaths (1 in 5 deaths worldwide). (wikipedia.org)
  • Guidet B, Aegerter P, Gauzit R, Meshaka P, Dreyfuss D. Incidence and impact of organ dysfunctions associated with sepsis. (jamanetwork.com)
  • Background: Sepsis likely contributes to the high burden of infectious disease morbidity and mortality in low income countries. (elsevier.com)
  • We hypothesized that a tandem repeat polymorphism (AC)n in the CXCL2 gene, previously associated with susceptibility to severe sepsis, contributes to morbidity and mortality in severe sepsis. (cdc.gov)
  • Sepsis is associated with high morbidity and mortality ( 1 - 4 ) and accounted for $23.7 billion in health care expenditures in 2013 ( 5 ). (cdc.gov)
  • Sepsis in mother and infant is a major cause of perinatal morbidity and mortality in low-resource settings. (knowcancer.com)
  • Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality. (jamanetwork.com)
  • Focused interventions to improve processes and outcomes of care at the hospitals that disproportionately treat blacks could narrow disparities in overall mortality from severe sepsis. (nih.gov)
  • Patient characteristics, ICU interventions, and outcomes were compared across nutrition status categories (expressed as age- and sex-adjusted body mass index z scores using World Health Organization standards). (elsevier.com)
  • Now, a new, multicenter research consortium, called Protocolized Care for Early Septic Shock (ProCESS), is beginning a large-scale study to determine whether specific interventions can halt the progression to severe sepsis and septic shock. (medicalxpress.com)
  • Two investigators independently collected data on patient and study characteristics, treatment interventions, and outcomes. (annals.org)
  • The challenge of investigating whether interventions that independently, or in combination with others, improve outcomes or cause harm may prove difficult ( 26 ). (frontiersin.org)
  • [8] People with sepsis need preventive measures for deep vein thrombosis , stress ulcers and pressure ulcers , unless other conditions prevent such interventions. (wikipedia.org)
  • While viruses, fungi and parasites all have the ability to trigger sepsis, bacterial infections are currently the most common cause. (lewrockwell.com)
  • Untreated serious bacterial infections in febrile young infants can have severe outcomes. (ebmedicine.net)
  • Among young infants presenting with fever, untreated serious bacterial infections can have severe outcomes, so a full sepsis workup is often recommended but may not be necessary. (ebmedicine.net)
  • Important biological mediators of sepsis are inflammatory cytokines including TNF-α, IL-1, and IL-6, which are released by leukocytes in massive amounts in response to bacterial toxins such as LPS. (jimmunol.org)
  • Infections leading to sepsis are usually bacterial but may be fungal, parasitic or viral. (wikipedia.org)
  • 3 That said, research 4 has demonstrated the number of fungal-induced sepsis infections is on the rise. (lewrockwell.com)
  • Information on patient demographics, risk factors, and infections leading to sepsis is needed to integrate comprehensive sepsis prevention, early recognition, and treatment strategies. (cdc.gov)
  • The lists of medical records were sorted into random order, and samples of records were selected and reviewed to identify demographic characteristics, underlying conditions, and infections leading to sepsis. (cdc.gov)
  • This potentially renders them more susceptible to influenza infections, which in themsevles may engender higher viral loads due to increased iron availability and thus produce more severe symptoms. (bmj.com)
  • The ICU admission rate for severe infections was several times higher for Indigenous than for non-Indigenous children, particularly for S. aureus infections. (mja.com.au)
  • The etiology of community-acquired Sepsis and severe Sepsis expressed in percentages of enrolled subjects. (patientsville.com)
  • CONCLUSIONS: Hypothermia was associated with a significantly higher disease severity, mortality risk, and lower implementation of sepsis bundles. (elsevier.com)
  • There are 3 levels of severity of anoxo-ischemic encephalopathy (EAI): mild, moderate and severe. (bioportfolio.com)
  • Maternal sepsis can be a severe complication of pregnancy or birth, which if untreated, can rapidly progress along a continuum of severity to septicaemic shock and eventually death. (ox.ac.uk)
  • Disease severity partly determines the outcome. (wikipedia.org)
  • Population-based rates of severe sepsis by age and race in six U.S. states, 2001. (nih.gov)
  • 1 For example, consistent with other data, one large epidemiological study found that women have lower age-specific incidence rates of severe sepsis when compared to men. (amwa-doc.org)
  • Early goal-directed therapy in the treatment of severe sepsis and septic shock. (jamanetwork.com)
  • The antibiotic cefotaxime has already been confirmed to be safe and effective for the treatment of severe sepsis and is not under scrutiny in this study. (isrctn.com)
  • or 2) physician diagnosis of severe sepsis or septic shock. (westjem.com)
  • A clinical diagnosis of severe sepsis. (ox.ac.uk)
  • The early identification of severe sepsis and the early implementation of a sepsis screening tool improve the outcomes. (topwritingservice.com)
  • The prognostic factors for severe sepsis and septic shock identified in this study were age, base deficit and ARDS. (biomedcentral.com)
  • The aim of the present study was to identify prognostic factors in 54 consecutive cases with abdominal sepsis admitted to the intensive care unit (ICU) over a two-year period, from January 2001 to December 2002. (journals.co.za)
  • A matched cohort study was conducted to analyze the relationship between IFI and outcomes of severe sepsis. (biomedcentral.com)
  • for the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group. (acpjc.org)
  • secondary outcomes included the number of days without renal or cardiovascular failure and the ventilator-free days during the study period. (cdc.gov)
  • Incidence, risk factors, and outcome of severe sepsis and septic shock in adults: a multicenter prospective study in intensive care units. (jamanetwork.com)
  • This study aimed to evaluate the association between percentage fluid overload (%FO) and paediatric intensive care unit (PICU) mortality in children with severe sepsis and septic shock . (bvsalud.org)
  • Design: Secondary analysis of the Sepsis Prevalence, Outcomes, and Therapies study. (elsevier.com)
  • On the upside, "Enthusiasm for this drug combination in sepsis has grown rapidly" since the release of Marik's initial study results, and much larger studies are now underway. (lewrockwell.com)
  • Short women with severe sepsis-related acute lung injury receive lung protective ventilation less frequently: an observational cohort study. (biomedsearch.com)
  • [1] On October 25, 2011, Eli Lilly & Co. withdrew Xigris from the market after a major study showed no efficacy for the treatment of sepsis . (wikipedia.org)
  • One study using a large, national dataset found that women with severe sepsis or septic shock were about 10% more likely to die compared to men, a finding supported by multiple smaller observational studies. (amwa-doc.org)
  • Wives whose husbands were hospitalized for severe sepsis were nearly four times more likely to experience substantial depressive symptoms, according to the study released July 18 ahead of the August publish date in Critical Care Medicine . (bio-medicine.org)
  • The study is believed to be the first of its kind in gauging depression among spouses of severe-sepsis survivors. (bio-medicine.org)
  • Hannah Mitchell, BMBS, of Children's Hospital of Philadelphia (CHOP), USA, who led the study, said: "Some of the disparities in outcomes from sepsis that we've identified related to race/ethnicity and socioeconomic position are alarming, but this analysis is an important step towards working out why they exist and what measures can be taken to address them. (eurekalert.org)
  • was to determine the total outcome, the cost, and the incidence of all the cases of severe sepsis in the United States through the observational cohort study. (topwritingservice.com)
  • Energy Balance in Critically Ill Children With Severe Sepsis Using Indirect Calorimetry: A Prospective Cohort Study. (bioportfolio.com)
  • Sepsis Using Indirect Calorimetry: A Prospective Cohort Study. (bioportfolio.com)
  • International sepsis survey: A study of doctor's knowledge and perception about sepsis. (springer.com)
  • In this study we hypothesized that HIF-1α could play an important role in mediating the inflammatory responses during LPS-induced sepsis. (jimmunol.org)
  • Objective To examine the association between the presence of individual principal investigators' financial ties to the manufacturer of the study drug and the trial's outcomes after accounting for source of research funding. (bmj.com)
  • Main outcome measure Association between financial ties of principal investigators and study outcome. (bmj.com)
  • In unadjusted analyses, the presence of a financial tie was associated with a positive study outcome (odds ratio 3.23, 95% confidence interval 1.7 to 6.1). (bmj.com)
  • In the primary multivariate analysis, a financial tie was significantly associated with positive RCT outcome after adjustment for the study funding source (odds ratio 3.57 (1.7 to 7.7). (bmj.com)
  • These characteristics did not appreciably affect the relation between financial ties and study outcomes (odds ratio 3.37, 1.4 to 7.9). (bmj.com)
  • 6 A systematic review of the role of funding on study outcome showed that industry funded studies were more likely than non-industry funded studies to have positive efficacy results (risk ratio 1.24, 95% confidence interval 1.14 to 1.35). (bmj.com)
  • While there are several well-established risk factors for maternal sepsis including caesarean section 10 , 11 , 12 , 13 and anaemia 12 , 14 , there has been no national-level study of the incidence or risk factors for this complication in the UK. (ox.ac.uk)
  • Adjusted rate ratios of severe sepsis in six U.S. states, 2001. (nih.gov)
  • 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. (medscape.com)
  • Suspected sepsis is used to indicate people who might have sepsis and require face-to-face assessment to determine whether they need urgent intervention. (nice.org.uk)
  • People with suspected sepsis who do not currently meet any high or moderate to high risk criteria of severe illness or death from sepsis. (nice.org.uk)
  • EPs' sepsis diagnoses reflect risk-stratification beyond the severe sepsis criteria. (westjem.com)
  • Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (sepsis-3). (springer.com)
  • When compared with the reference standard - prospective clinical diagnosis - ANZICS CORE database criteria significantly underestimate the incidence of sepsis and overestimate the incidence of septic shock, and also result in lower estimated hospital mortality rates for each condition. (mja.com.au)
  • Many conditions mimic sepsis by meeting criteria for SIRS. (epmonthly.com)
  • Unfortunately, these criteria are non-specific, and the criteria alone do not provide a diagnosis or predict outcome. (epmonthly.com)
  • We determined diagnostic test characteristics for qSOFA scores, SIRS, severe sepsis criteria and lactate level thresholds. (bmj.com)
  • 2202 (58.8%) met SIRS criteria and 1085 (29.0%) met severe sepsis criteria. (bmj.com)
  • qSOFA criteria for sepsis include at least two of the following three: increased breathing rate, change in the level of consciousness, and low blood pressure. (wikipedia.org)
  • The drop in blood pressure seen in sepsis can cause lightheadedness and is part of the criteria for septic shock. (wikipedia.org)
  • Age-, sex- and race-standardized severe sepsis incidence and inpatient case fatality rates, adjusted incidence rate ratios, and adjusted intensive care unit (ICU) admission and case fatality rate differences. (nih.gov)
  • Participants will be contacted at 28 days after admission to determine clinical outcome by phone interview with standardized script. (clinicaltrials.gov)
  • Age-standardized hospital admission rates for sepsis were calculated. (springer.com)
  • Census data identified broad socio-demographic risk factors for admission to hospital with sepsis. (springer.com)
  • We evaluated the relationship between 1 ) the number of days with hypoglycemia (predictor variable) during the hospital admission and 2 ) hospital mortality (primary outcome variable). (diabetesjournals.org)
  • We obtained data on admission demographics, process of care and outcomes from hospitals and ICUs that are part of the Canadian Critical Care Research Network (CCRNet), a collaboration of urban and nonurban primary, secondary and tertiary care facilities. (cmaj.ca)
  • The primary outcome was direct ED to ICU admission. (rug.nl)
  • The secondary outcomes were in-hospital, 28-day and 6-month mortality, indirect ICU admission and length of stay. (rug.nl)
  • Our primary outcome was critical illness, defined as one or more of the composite outcomes of death, vasopressor use or intensive care unit (ICU) admission within 72 hours of presentation. (bmj.com)
  • This was a retrospective record review of cases with abdominal sepsis admitted to the ICU. (journals.co.za)
  • The eASSIST project (electronic Application of a Pediatric Severe Sepsis EMR-Integrated Screening Tool) was launched after detailed analysis and the creation of an offline retrospective database to simulate an EMR-integrated screening tool. (lebonheur.org)
  • When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK. (bioportfolio.com)
  • Service providers (such as primary and secondary care services) ensure that information is available about symptoms to monitor and how and when to access medical care for people with suspected sepsis who have been stratified as being at low risk of severe illness or death from sepsis. (nice.org.uk)
  • Homocysteine levels were not significantly associated with any primary or secondary outcomes in the multivariable analysis. (cdc.gov)
  • Secondary outcomes were 28-day ventilator -free days (VFD), intensive care unit -free days (IFD) and inotrope-free days (InoFD). (bvsalud.org)
  • The primary outcome was death prior to discharge, and the secondary outcome was length of hospital stay. (eurekalert.org)
  • The primary outcome was the level of platelet (PLT) on the 7th day of treatment, and secondary outcomes were 28-d mortality, the level of coagulation indicators, hepatic and renal function indicators, blood transfusion, and length of intensive care unit (ICU) stay. (frontiersin.org)
  • The secondary outcomes include all-cause hospital mortality during the first 7 days and all-cause mortality at 1 year. (bmj.com)
  • Data on sepsis prevalence on the general wards is lacking on the UK and in the developed world. (mendeley.com)
  • 3 , 4 The resolution therefore specifically urged WHO member states to investigate the national prevalence and profile of sepsis, and to develop and foster epidemiologic surveillance systems. (mja.com.au)
  • To this end, September 13 has been designated "World Sepsis Day" to raise awareness. (lewrockwell.com)
  • Objectives: The impact of nutrition status on outcomes in pediatric severe sepsis is unclear. (elsevier.com)
  • We studied the association of nutrition status (expressed as body mass index z score) with outcomes in pediatric severe sepsis. (elsevier.com)
  • The prognostic value of left ventricular systolic function and cardiac biomarkers in pediatric severe sepsis. (bioportfolio.com)
  • In the hospital setting, especially the emergency department sepsis is not always recognized early enough to implement life saving measures. (topwritingservice.com)
  • EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. (springer.com)
  • What is bacteremia and how is it associated with sepsis? (medscape.com)
  • Elevated serum TBIL level is associated with poor outcomes in pediatric SALI. (hindawi.com)
  • Establishing this epidemiology is vital to the prevention of poor outcomes for mothers and their infants. (ox.ac.uk)
  • Are there any factors that are associated with poor outcomes? (ox.ac.uk)
  • If possible, we will carry out a meta-analysis to provide a pooled prognostic effect estimate for each outcome. (bmj.com)